Method for health promotion
FIELD: medicine, in particular therapy.
SUBSTANCE: claimed method includes peroral administering of preparation from brown algae at least two time per day. Said preparation represents gel form homogenized brown algae having particle size 500 mum or less and containing at least 15 mg/kg of iodine and carbohydrate fractions: mannat 133.4±12.1 mg/g, alginic acid 147.8±10.7 mg/g. Preparation is administered for 30 min before eating in amount of 1-5 g/kg/day. Daily dose is 50-250 g. Course of treatment is 4-24 weeks.
EFFECT: preparation of increased antioxidant and immunomodulating action.
6 cl, 3 tbl, 6 ex
The invention relates to methods for recovery of the human body, i.e. restoring the normal functions of the body using the power of biologically active products, in particular food product "Algae brown homogenized (laminaria and fucus) for diet and preventive nutrition", produced from varieties of kelp (seaweed) and/or fucus, and can be used as a new health and preventive medical technologies for use by physicians of rehabilitation medicine, physiotherapists, nutritionists and other health professionals.
Insufficient iodine in the human body (hypothyroidism) impaired synthesis of thyroid hormones. Iron starts to increase in volume, due to tissue growth to ensure the development of the missing amount of hormones. Resulting in the development of endemic goiter. In addition, there is a decrease of immunity, therefore, is marked mental retardation, weakness, problems with vision, can develop exophthalmia. Iodine deficiency adversely affects the overall development of children: a poorly developed brain and bone system, the child lags behind in mental and physical development, suffers his immune system. In pregnant women increased the highlighted risk of miscarriage, born deaf and mentally retarded children. In addition, modern bad habits, such as irregular and irregular diet, stress, lack of physical activity, are important causes of increased acidity of the human body. Too high a protein intake caused by the abuse of meats, sausages and cheeses, causes our body in large quantities produces acid, which lead to his zashlakovyvaniya. This process is further enhanced due to the overuse of coffee, sodas, sweets and pastries, as these products deprive the body of essential neutralizing substances. This, in turn, leads to disruption of cellular metabolism, i.e. cells are insufficiently supplied with oxygen and nutrients. The lack of individual components in the diet can lead to manifest pathology (anaemia, immunodefeciency and others), and to various diseases or to border state between health and disease. All of the above phenomena make the actual improvement of the human body, otherwise it will increase the morbidity and mortality of the population.
There is a method of healing (cleansing) of the body using a medical collection that contains hawthorn, W is bownik, calendula, nettle, tansy, motherwort, series, yarrow, bilberry leaf and Senna, sage, St. John's wort, coriander seed, buckthorn bark, licorice, kidney tea, calamus root, celandine (RU # 2097052, CL AC 35/78, 1997).
The disadvantages are the limited scope of its application, because it is not suitable for the excretion of toxic substances, minor and slowly reached therapeutic effect, the short duration of action, low attractiveness on organoleptic (unpleasant aftertaste), not using the whole Arsenal of biologically active substances of medicinal herbs, as individual components fees inhibit each other.
There is a method of healing the body using the phytocomplex, contains chitosan extract, brown seaweed (laminaria), green algae, red algae, spirulina and elastin (RU # 2252016, CL AC 35/78, 2005).
The disadvantage of this method is the limited scope of its application is only for vitalization and restore balance to the skin and opportunities, because it is not suitable for removal from the body of the most toxic substances.
The closest is the way to healing the body, which includes the oral administration of a set of food substrates and regulators of the metabolism of ownership the military microflora in the form of a complex bran with herbal supplements - carriers of micro and macro elements of the series: green tea, seaweed (kelp), chaga, agar-agar, cottonweed marsh - 2-3, a native of macronutrients from a number of: nettle, lemon balm, horsetail and 1.5 - 2.5, regulators of microbial fermentation of a range of cardamom, chili, red pepper, black pepper, nutmeg - 1,0-2,0, initiator fermentation - improver - 0.2 to 0.5. Before the introduction of food substrates are disposable lavage procedure appropriate preparation or purification of the protein and vegetable enema capacity of 1.5-2 l (RU # 2277929, publ. 2006.06.20).
The disadvantages of this method are the limited scope of its application, because it is not suitable for removal from the body of the most toxic substances such as lead, mercury, cobalt and radioactive elements derived uranium, insignificant slowly achieved therapeutic effect, not using the whole Arsenal of biologically active substances of marine plant materials, the short duration of action, low attractiveness of sensory indices used products (unpleasant aftertaste).
An object of the invention is the creation of an effective way of healing the human body and expanding Arsenal of methods of healing the human body.
The technical result consists in the rasshirenie range of applications for restoration of functions of all major organs, ensuring recovery of disturbed metabolism, increasing the body's resistance in diseases of the gastrointestinal tract, cardiovascular and endocrine systems, as well as antioxidant and immunomodulatory actions, with minimal likelihood of side effects, excretion of various toxic substances, such as lead, mercury, cobalt and radioactive elements derived uranium, reducing the time to obtain meaningful results, simplifying the process of recovery due to the exclusion of physiotherapeutic procedures that cannot be performed without assistance.
The essence of the invention is that the method of healing the body includes a daily oral intake of patients of the drug from brown algae, produced at least two times a day before meals for 4-24 weeks, as drug taking gel from homogenised brown algae with a particle size of not more than 500 μm and iodine content of not less than 15 mg/kg and carbohydrate fractions: mannat - 133,4±12,1 mg/g, alginic acid - 147,8±10,7 mg/g, in an amount of from 50 to 250 g day.
Preferably the gel from brown algae are 30±5 minutes before a meal, in the amount of not less than 1 year and not more than 5 g per kilogram of body weight per day.
In addition, the gel from brown algae, what about the least twice a day is used in the form of applications available on the affected area.
When this gel from brown algae is produced by processing, including cutting of raw materials, which take fresh thallus brown algae, rhizoids cut off, washed with water and dried, and then washed in fresh water at a temperature of 25-35°within 20-50 minutes with occasional stirring for uniform swelling of not less than 30%, then make the demineralization of algae, which is infused with 0.5% solution of edible acid from the group of acetic, citric or hydrochloric acid having an acidity of pH=2,0, when the mass ratio of algae and mortar equal to 1:1,5, and incubated for 1-2 hours, after which they are washed from acid in fresh water for 10-12 minutes and soaked in drinking water at a temperature of 20-35°C for 30-50 minutes with the change of water during soaking, and after the last washing, give water to drain for 10 to 20 minutes, washed algae are crushed and boiled, which is poured drinking water with a temperature of 75-85°when the mass ratio of algae and water is 1:1, add sodium bicarbonate until the value of acidity pH=7,0 to 8.0, which is controlled in the cooking process that is carried out within 6-10 hours at a temperature of 70-80°With continuous stirring, after h is th is cooled to 35-45° C and homogenize for 30 min, and then produce neutralization, which impose solutions of citric acid in an amount of 0.1% and lactate or calcium citrate in an amount of 0.2% by weight of algae, stirred and heated to 75°C.
Preferably as brown algae take seaweed from the group of laminaria and fucus from the basin of the Okhotsk, Bering and Japanese seas.
The inventive method is based on the fact that brown algae contain large amounts of iodine, which is present in them in organic form. Among these organic compounds are present plant analogs (prohormones) iodine-containing thyroid hormone - thyroidin, which is able to normalize the thyroid gland with decreased function of the thyroid gland. Also contained in brown algae mannitol and alginic acid act as sorbents. The content of the alginic acid reaches 30% of the dry mass of algae.
Kelp is one of the most common representatives of brown algae. Dwells in the far Eastern and Northern seas. Thallus algae attached to the substrate by rhizoids. From rhizoids up leaves cylindrical barrel (up to 50 cm long), he goes in whole or dissected record length of 4-5 m Other common representative of brown algae JW is aetsa fucus. Represents a branched Bush attached to the substrate disk (rhizoid). Branches renneville, some are pneumatic cavities filled with air and used to maintain plants in a vertical position.
As shown, in its natural form useful components of brown algae is not effective enough. For example, in the far Eastern areas of Russia's population, having the ability to systematically consume seafood, including laminaria (kelp), susceptible to diseases typical of iodine deficiency and metabolic almost to the same extent as in the European part. An important drawback of the known products is the low digestibility included in its composition of iodine. This is because the acceptance of products containing iodine in natural form is not sufficiently effective for healing the human body and rapidly excreted from the kidneys. In this regard, commercially available preparations containing mainly iodine in natural form, is not suitable for nephritis, hemorrhagic diathesis and other States in which unwanted iodine preparations.
This required the creation of such a form of product that allows the human body to naturally absorb useful components of brown algae in the normal mode of life and time is mnih the dosage, i.e. to ensure a real improvement of the body.
The gel from brown seaweed is an active enterosorbent, it can be used for binding and accelerated excretion of various toxic substances, such as lead, mercury, cobalt and radioactive elements derived uranium, etc.
In addition, on the basis of studies carried out by Russian scientists, it was found that the gel from brown seaweed is a wonderful modulator, able to normalize metabolism (protein, carbohydrate, fat) at the level of different organs, tissues and human cells. This makes it great product that can be used in regenerative medicine for the health of the healthy person and the prevention of many diseases.
Fucoidan and kelp inhibit and suspend the excessive growth of smooth muscle cells in the vascular wall, which is one of the most important elements in blocking the development of atherosclerotic plaques, activate enzymes involved in beta-oxidation of fatty acids, which, in the first place, helps to reduce cholesterol, improve fat and carbohydrate metabolism. Alginates (make up 35% in the gel from brown algae) have the unique ability of enterosorbent, bind to heavy metals, toxic and is adioactive substances, forming with them a complex.
Due to the fact that the alginates in the intestine is not digested and not absorbed and is excreted with the stool, or things associated with them freely excreted. This applies not only to the toxins that enter the body with food and water, but also other toxic substances that enter the intestinal lumen of organs, tissues, blood.
A multicellular organism is a holistic organization, cellular elements which are specialized to perform different functions. The interaction inside the body is a complex regulating, coordinating and correlating mechanisms involving neural, humoral, metabolic, and other factors. Many individual mechanisms regulating intra - and intercellular relationships, have in some cases mutually opposite effect, counterbalancing each other. This leads to the establishment of a body rolling physiological background (physiological balance or homeostasis) and allows living systems to maintain the relative dynamic stability, despite changes in the environment and the shifts that occur during the life of the organism. When this homeostasis is integral to the concept of functionally and morphologically combining cardio-suck the East system, the respiratory system, digestive system, renal system, water and electrolyte metabolism, acid-base balance. Violation of physiological balance, including and associated with a lack of various substances, manifests itself in the form of diseases. The inventive method aimed at returning the body to its original optimal state after the deviation, caused by one or another "disturbing" factor.
The method is implemented as follows.
Patients lead a normal life at the following approximate mode:
6.30 hours - rise;
6.30-6.45 - morning toilet;
7.00-7.30 am - Breakfast;
8.30-18.00 - work;
13.30-14.00 - lunch;
18.30-19.00 - rest.
19.00-19.30 - dinner;
19.30-22.30 - rest (book, TV);
22.30-6.30 - sleep.
An example of the daily diet.
Breakfast: Cup of tea, a sandwich with sausage/cheese.
Lunch: soup, potatoes with chicken, tea.
Dinner: porridge, tea sandwiches.
Three times a day before meals for 4-24 weeks take oral gel from homogenised brown algae with a particle size of not more than 500 μm and iodine content of not less than 15 mg/kg and carbohydrate fractions: mannat - 133,4±12,1 mg/g, alginic acid - 147,8±10,7 mg/g, in an amount of from 1 to 5 g per kilogram of body weight, i.e. at least 50 g and 500 g for adults weighing 50 to 100 kg
Reception gel from brown algae, it is preferable to assign C the 30± 5 minutes before eating.
Finally individual dose oral administration of the gel from brown algae is preferably administered in an amount of not less than 1 year and not more than 5 g per kilogram of body weight per day, in the above-mentioned limits.
If necessary healing skin gel from brown algae, at least two times a day is used in the form of applications available on the affected area for 3-5 g / cm2surface.
The gel from brown algae to implement the proposed method of recovery receive preferably by processing of brown algae, as follows.
In the recycling process performs the following steps :
1. Preparation of seaweed.
As brown algae take seaweed from the group of laminaria and fucus from the basin of the Okhotsk, Japanese or Bering seas, outside the zone of discharge of industrial and domestic waste. Production of algae produced in accordance with Instruction No. 6, approved by the order "DALRYBA" No. 466 dated July 10, 1985, the Use of seaweed, raw or dried, are permitted for use in food industry SSES of the Russian Federation.
The fresh brown algae take thallus (the stalk of the sea), cut off the rhizoids (growths) manually or on a disk knives. Produce the withdrawal of unprofitable plants.
Thallus washed m is rccoi water cascading or vortex sink or method dushirovaniya. If on the surface of the thalli of spirorbis (shells) of their cleaning is performed manually by brush followed by rinsing.
After washing the thallus is placed on a mesh tray for draining water and drying. Dry seaweed washed in fresh water in the bathtub method dushevnie laundering from sand and salt. After this, at a temperature of 25-35°To provide exposure for 20-50 minutes with occasional stirring for uniform swelling of at least 30%.
Seaweed infused with 0.5% solution of acetic or citric or hydrochloric acid (pH=2,0) when the mass ratio of algae and mortar of 1:1,5, and incubated for 1-2 hours.
After a specified time of seaweed washed from acid in fresh water dushevnie for 10 minutes and soaked in a bunker in drinking-water at a temperature of 20-35°C for 30-50 minutes with 1-2-fold change of water during soaking.
After the last washing tank with algae is lifted from the tank and allow the water to drain out within 10-20 minutes.
The washed algae are ground in a meat grinder M-250, MIM-300, MIM-600, TJI2H (produced in China) or rubbing machine MPR-350.01 and loaded into the cooking container.
Shredded seaweed is loaded into the cooking vessel with the ratio of the applied heating powerfully the tee and useful volume, equal 0,040-0,045 kW/l, for example, the reactor volume 1050 l with electric heaters with a capacity of 45 kW and tarabasanu space for heating with superheated steam or electric boiler with a stirrer (with the same ratio of electric power and volume) and with thermally shirt. In the reactor pour hot potable water at a temperature of 75-85°in relation to the mass of algae 1:1, add sodium bicarbonate to obtain a pH=7,0-8,0 controlled in the process of cooking, and stevioside to 1 mg per cent mass. Boiling is carried out for 6-10 hours at a temperature of 70-80°With continuous stirring by a stirrer speed of 15-25 rpm
After cooking the resulting mass is cooled to 35-45°and homogenized for 30 min, for example, a homogenizer brand RPA. Rotary pulsation apparatus (RPA) combines the principles of operation of the generator hydrodynamic fluctuations and centrifugal pump. By pulsation, percussion and hydrodynamic effects, the influence of centrifugal forces, together with the hydro-acoustic and hydrodynamic fluctuations occurring in the RPA, change the physico-mechanical properties of the product, which is converted in the most effective and convenient for absorption by the body shape with the size of the cha the TIC is not more than 500 μm. In the process of homogenization of the particles are crushed to about one micron, is uniformly distributed in the mass of the product. Under the influence of pulsation, percussion and hydrodynamic effects, together with the hydro-acoustic and hydrodynamic fluctuations are the processes of dispersion, emulsification, dissolution, extraction, oxidation and polymerization. At the same time intense acoustic stimulation leads to destruction at this stage, bacteria and microorganisms. Released substances peptide is able to regulate different stages of proliferation and differentiation of T-lymphocytes, that is, to act on parts of the immune response. Homogenized product does not separate during prolonged storage, suitable for transportation, while maintaining their physiological properties.
In gomogenizirovannogo weight enter the solutions of citric acid in an amount of 0.1% by weight of algae and 15-25% solution of salt of calcium in the amount of 0.2% by weight of algae. As a solution of salt of calcium enter solution of calcium lactate or calcium citrate. At this stage can be entered aromatic additives (according to a specific recipe, for example, lemon balm or cumin in the amount of 0.05% by weight of algae). The mass of carefully move the're asked for 10 minutes. In the process there is a release of alginic acid, which is an intercellular substance and a component of the cell walls of algae. Introduced substances form complex compounds with products homogenization of algae, mainly alginates, sodium-calcium. A large part of the iodine is in the form of a naturally digestible itorganize compounds. The synergistic effect of the ingredients in optimally chosen active doses used for prevention of secondary immunodeficiency, resulting from the action of stress, vaccination, radiation or chemotherapy treatment, transplacental transmission of influenza virus to the fetus, as well as from age-related changes of immune systems, which are factors of emerging diseases.
Then the mass is heated to 75° (pasteurized) and transform into a form suitable for storage, for example Packed in hot or served on drying.
10. The drying.
For drying, use the installation freeze-drying P1-ISS-101, installation type TG-15 or TG-50 (Germany) or vacuum drying SPT-200, spray drying "Niro atomizer or convection drying IP 120 (Hungary).
Prepared pasteurized mass is poured into moulds or in the cell layer is not more than 10 mm, which are placed on shelves in the drying unit, where the mass is dried Final moisture of the product should not exceed 10%.
11. The packing.
11.1. Packing in dry form.
Powdered drug is Packed in termosvarenny film packages on THE 15-1106-90 limit weighing 100 g or other containers made of materials approved for food contact by the state sanitary and epidemiological supervision of the Russian Federation and ensure the safety of products.
11.2. Packing hot.
A lot Packed in hot dispenser UD-2 or UFW in sealed containers and cool.
The resulting gel contains 92-94% of water, 6-8% of dry substances, which include alginic acid 5-6% in the form of sodium alginate-calcium, fiber - 1-1,5%protein - 1%, mineral micro - and macro-elements: molybdenum (12×10 - 3%), manganese (4,4×10 - 3%), iron (13×10 - 3%), fucoidan, stevioside and other. Nitrogenous compounds represented by 17 amino acids, among which 7 are indispensable. The resulting product is elastic sliding consistency, pleasant sweet-sour taste and invigorating aroma with notes of Jasmine and mountain herbs. Persistence (stability) properties were controlled within 6-8 months of storage at a temperature of 8-12°appearance - preserving flavour, colour, consistency and smell, no delamination, blistering, gas. Changes in these indicators during storage was not found.
In the preparation of the gel using the following ingredients:
- kelp is about GOST 20438 (or sea cabbage raw in THE 15-01-360);
- focusy food on the EAST 64-026-87;
- acetic acid according to GOST 61-75;
- citric acid food according to GOST 908-2004;
- hydrochloric acid according to GOST 3118 or GOST 3857;
- calcium citrate on THE 6-09-01-263-85;
- calcium lactate on THE 6-09-3839;
- stevioside on current regulatory and technical documentation or received import;
sodium bicarbonate (sodium bicarbonate) according to GOST 4201;
- drinking water according to GOST R 51232 with hardness up to 1 mol/m3or softened (fixed) drinking water with a pH of not more than 7.8 and rigidity to 0.2 mol/m3.
While sodium bicarbonate (sodium bicarbonate) - exert alkaline medium, the crystalline white powder, odourless. Chemical formula NaHCO3.
Sodium bicarbonate is an antacid agent. When administered interacts with HCl gastric juice, neutralizing it. Increases excretion of Na+ and Cl-, osmotic diuresis; shifting in the alkaline reaction of bronchial mucus, increases bronchial secretion, reduces sputum viscosity and improves its expectoration. Eliminates pain syndrome with ulcer and 12 duodenal ulcer. Alkalization of urine prevents the deposition of uric acid in the urinary tract. In its pure form in the reaction of neutralization of CO2can cause discomfort in the stomach Idrijca.
Calcium citrate (calcium citrate) (e), chemical formula [OOS(HE)(CH2Soo)2]2CA3·4H2O - calcium citrate chetyrehpolnye - calcium, approved and recommended for use in the food industry. Products are accompanied by a Sanitary-epidemiological conclusion of the Ministry of health of the Russian Federation.
It is established that calcium ions are involved in excitation and contraction of muscle cells, ensuring the permeability of cells, intercellular interactions, coagulation of blood, secretion of hormones, neurotransmitters, enzymes. The extracellular space they penetrate into the cytoplasm of special calcium channels, affecting various physiological processes function cells of all organs, vascular tone, the intensity of systole, diastole. Calcium ions play an important role in the formation and preservation of bone tissue. Calcium citrate supplements lack of calcium ions in the body for functional (physiological increased need for growth, normal blood loss in women, leaching of bone calcium in the elderly and so on) and pathological (trauma, bleeding, malabsorption in the gastrointestinal tract, the failure of reabsorption of calcium in the kidneys and other) insufficient replenishment of the body's calcium ions. Using the drug in its pure form m who may experience a loss of appetite, pain in the abdomen.
Calcium lactate - calcium, approved and recommended for use in the food industry. Products are accompanied by a Sanitary-epidemiological conclusion of the Ministry of health of the Russian Federation.
Calcium lactate regulates phosphorus metabolism, anti-inflammatory, protivorahiticescoe, vitamin and hemostatic effect. Accelerate all phases of blood clotting, improves adhesion of platelets, promotes rapid entry into the blood tissue thromboplastin. Using the drug may experience heartburn.
Stevioside is a natural sweetener extract honey stevia (Paraguay). Stevioside approximately 200-300 times sweeter than sugar, no-calorie, does not cause decay. Stevioside improves the cardiovascular, immune and other systems; thyroid, liver, kidney, spleen. Normalizes blood pressure, antioxidant, adaptogenic, anti-inflammatory, antiallergic and mild choleretic action. It inhibits the development of many microorganisms and is therefore recommended for oral diseases: protects teeth from tooth decay and gum from parodontosis, which is a common cause of tooth loss, including diabetes, helps prevent unpleasant mouth odor.
Below are examples of the practical is the second implementation of the method of healing the body.
Evaluation of the effectiveness of health iodine deficiency was made in two groups of pregnant women. 1 experienced team of 47 people, 2 control group of 41 people.
|Dynamics of the content of the iodides of blood (mmol/l) in pregnant women after taking the gel from brown seaweed|
|The period of examination and admission gel (weeks)||8-12 (original)||16-24||28-32||34-38|
Found significant differences in the content of the iodides of blood before and after a course of reception of gel in women with iodine deficiency. The first group consisted of pregnant women who received the gel from brown algae by 50±5 g of the gel for 30 minutes before eating in the morning and in the evening for 12 days before each control study. Of these 15 women received the product with a particle size of 100-200 μm, the retention of which was 5.5 months, to prepare which was only used kelp as food calcium salts - calcium citrate, in this role in the composition of the product was administered stevioside, other 14 women - product with a particle size of 150-250 μm, the retention of which was 6 months, to prepare which was used only fucus, and as a dietary calcium salt is calcium lactate, in this role in the composition of the product was administered stevioside, the remaining 18 women - product shelf life which was 6 months, to prepare which was used laminaria and fucus mass ratio of 2:1, and as a dietary calcium salt is calcium citrate.
The second group of pregnant patients received one of the drugs, containing kelp, Laminaria or Lumican-L (aqueous concentrate kelp), almost equivalent to the prototype.
Control was accomplished by determining the activity of iodides in whole blood by direct potentiometry using ion-selective electrodes firm "Shush" (Czech Republic). OK, these numbers are 20-50 µmol/L. Initially, a comprehensive clinical and laboratory study was carried out at registration in female consultation in the early stages. Women had up to 12 weeks of pregnancy, the iodide content of the blood 12,32±2,23 µmol/l, was selected in the experimental and control groups. During the course of the comprehensive clinical and laboratory studies were carried out in 16-24, 28-32, 34-38 weeks b is of pregnancy. In the first group, upon receipt of the product - gel from brown seaweed - there is an increase in the content of the iodides of blood to the values near the lower limit of normal. In women who have known the product is registered only a slight improvement by the end of the course remained significantly below normal, i.e. iodine deficiency was offset slightly.
None of the patients treated with the gel from brown algae, not noted an unpleasant aftertaste, unpleasant sensations in the stomach, loss of appetite, abdominal pain. Indicating the improvement of the body, the improvement in the experimental group all women receiving any of the variants of the product was stable and remained in between courses of recovery. The patient noted a decrease in the incidence of colds and flu or a milder course of the disease.
The improvement of the body with the help of receiving the gel from brown algae with disorders of the gastrointestinal tract held on the following patient groups: experimental group - 52 people (26 men and 26 women) with an average age of 55±5 years. A control group of 30 people aged 55±6 years.
Patients complained of: nausea, belching, heartburn, epigastric pain and a feeling of heaviness in the right hypochondrium, bowel disorder in the form of diarrhea or constipation. When is issledovanii laboratory parameters in some patients showed increased level ACT, ALT, LDH and bilirubin, due to the indirect fraction. In the coprogram increased amount of fatty acids.
Experimental group for 21 days along with common in similar cases, the drugs got 100±5 g of gel produced by the claimed method, 30 minutes before meals morning and evening. 25 of them received the product with a particle size of 200-450 μm, to prepare which was used only kelp, and as a dietary calcium salt is calcium lactate, other 27 people - a product with a particle size of 300-500 μm, to prepare which was used laminaria and fucus mass ratio of 1:1, and as a dietary calcium salt - calcium citrate, in this role in the composition of the product was administered stevioside. The shelf life of these products accounted for 6 months. The control group received only known drug that contains kelp, Lamison-L.
Patients of the experimental group, starting with a 5-7 day course, noted steady improvement in overall health: normalization of appetite, decrease of heartburn, regurgitation, nausea, and normalization of stool. According to endoscopic and morphological studies have established the positive dynamics of changes in the mucous membrane of the colon, which was expressed in the reduction of inflammatory (89.4% of patients) and the elimination of erosive changes in the mucosa of the rocki colon (in 100% of patients), the decrease in cellular infiltration (74.8% of patients). Under the influence of gel from brown seaweed normalized chemical changes in Calais: pH were normalized in 98.3% of patients, organic acids and ammonia at 98,5%, mucin remained in Calais, only 4.7% of patients, tissue protein is not marked.
In the control group, the positive trend was less pronounced, health improvement occurred, usually in more remote periods (later on 10-18 days). Traits such as a sense of heaviness in the right hypochondrium, skin itching, leg pain, dyspeptic symptoms in the experimental group treated in a shorter time than in the control group.
In the biochemical analysis of patients from the experimental group who received both versions of the product, the content of total protein and bilirubin had a distinct tendency toward normalization, i.e. was the improvement of the patient's body. In the control group, positive changes were less pronounced and occurred in more remote periods. None of the patients taking the gel did not report discomfort in the stomach and burping, unpleasant aftertaste or other unpleasant phenomena.
Patients of the experimental group treated with any of the mentioned variants of the product, 18-21 day course marked improvement ultrasound picture of the liver. In the control group data ultrasound at this moment there be the significant changes. Most patients of the experimental group over the next 3-4 months without any complaints, typical of the beginning of the course of recovery.
The improvement with treatment gel from brown algae in disorders of the intestine conducted on 44 patients who were divided into two groups: basic - 24 people and a control group of 20 people. The average age of the patients (in both groups) was 51+4 year.
In the beginning of the course endoscopic examination with chronic constipation helped to identify bacterial due to structural changes of the mucous membrane of the colon, which was expressed in focal inflammatory (49.2 percent) changes, and the presence of erosions in the mucosa of the colon (31,1%). Morphological changes of the mucosa of the colon detected in all patients. There were violations of the ratio of conditionally pathogenic and saprophytic microflora of the intestine, conditionally pathogenic microflora was sown in 80.2% of patients. Patients in the control and experimental group in the analysis of a feces on a dysbacteriosis revealed the presence of Staphylococcus aureus and higher titer of E. coli. Two of the experimental group suffered from nephritis, one hemorrhagic diathesis.
Experimental group within 28 days received 75±5 g of the gel for 30 minutes before eating in the morning and vecera is. The control group received only standard medical treatment. From the experimental group of 11 people received the product with a particle size of 200-400 μm, the retention of which was 6 months, to prepare which was used only kelp, and as a dietary calcium salt - calcium citrate, in this role in the composition of the product was administered stevioside, other 13 people - a product with a particle size of 300-500 μm, the retention of which was 6.5 months for preparation which was used laminaria and fucus mass ratio of 1:2, and as a dietary calcium salt is calcium lactate.
Laboratory and instrumental methods of examination was conducted in accordance with standards.
According to endoscopic and morphological studies during the course of the patients of the experimental group showed positive dynamics of changes in the mucous membrane of the colon, which was expressed in the reduction of inflammatory (89.4 per cent) and the elimination of erosive changes in the mucous membrane of the colon (100%), the decrease in cellular infiltration (74,8%) patients. Under the influence of gel from brown seaweed normalized chemical changes in Calais: pH were normalized in 98.3% of patients, organic acids and ammonia were normalized in 98.5%of the mucin remained in Calais, only 4.7% of patients, tissue protein is not observed. All PA is antov experimental group in a shorter time, than in the control, was cicatrization of the ulcer, scar deformity was less pronounced, i.e. the improvement of the patient's body is achieved. The positive dynamics of the controlled characteristics of patients suffering from urological disorders did not differ from the dynamics of other patients, worsening of other indicators were not found. Patients reported a pleasant taste and smell of the product, no unpleasant aftertaste. Most patients over the next 4-5 months without any signs of dysbiosis and exacerbation of diseases typical for the beginning of the course of recovery.
Evaluation of the effectiveness of rehabilitation in patients with cardiovascular disorders was carried out in two groups. 1st group of 45 people (men and women) - experienced, 2 a group of 40 people (men and women) served as the control.
The first group was received within 45 days of the gel from brown algae, obtained by the claimed method, 60±5 g of the gel for 30 min before meals morning and evening. 25 of them received the product with a particle size of 15-150 μm, the retention of which was 6 months, to prepare which was used only kelp, and as a dietary calcium salt - calcium citrate, in this role in the composition of the product was administered stevioside, the other 20 people who - a product with a particle size of 15-200 μm, the retention of which was 6.5 months for preparation which was used laminaria and fucus mass ratio of 2:1, and as a dietary calcium salt is calcium lactate.
The second group received one of the known preparations containing kelp, Laminaria or Lumican-L.
|Changes in lipid and carbohydrate metabolism, blood pressure and prothrombin index under the influence of the oral administration of the gel from brown seaweed|
|Indicators||1st group||2nd group|
|Before the treatment||After the treatment||Before the treatment||After the treatment|
|Total cholesterol, mmol/l||6,09±0,2||5,13±0,32||7,2±0,30||6,84±0,31|
|Fasting plasma glucose, mmol/l||6,3±0,52||5,01±0,17||6,1±0,14||5,88±0,07|
|HELL beats., mm Hg||143,7±2,1||130,0±2,1||147,5±1,8||144,2±2,0|
|HELL of diastole., mm Hg||88,0±2,1||80,6±1,4||97,0±1,5||96,8±2,1|
|Prothrombin index, %||97,5±2,6||86,71±0,17||103,8±0,72||102,7±0,4|
The results in the table demonstrate more effective healing (normalizing) the influence of the drug, obtained by the claimed method, the pathogenetic links of cardiovascular disease, have occurred in patients receiving any of the variants of the product. Control tests taken after 3 and 6 months after completion of the course, showed that these figures were changed compared with the end of the course naznacite is Ino. Patients reported recovery efficiency, reduce the incidence of colds and flu or a milder course of the disease. Patients reported a pleasant taste and smell of the product, no unpleasant aftertaste or dyspeptic phenomena.
Evaluation of the effectiveness of rehabilitation of patients living in the area of lead contamination (area refinery gasoline production), using treatment gel from brown algae performed on 92 patients - men and women ranging in age from 17 to 73 years, randomly selected from the population living in the area 500-1500 m from the enterprise. Up to 75% of patients complained of headaches, dyspepsia, disorders (men).
All patients continued to live at home and received within 48 days of the gel from brown algae, obtained by the claimed method, 50±5 g of the gel for 30 minutes before eating in the morning, afternoon and evening. Of these 50 people received the product with a particle size of 30-120 μm, the retention of which was 5.5 months for preparation which was used only kelp, and as a dietary calcium salt is calcium lactate, the remaining 42 person - product with a particle size of 20-100 μm, the retention of which was 6.0 months, to prepare which was used laminaria and fucus in m is sovam ratio of 2.5:1, and as a dietary calcium salt - calcium citrate, in this role in the composition of the product was administered stevioside. None of the patients did not report discomfort in the stomach and burping, unpleasant aftertaste or other unpleasant phenomena.
Were made in accordance with the standards of the blood of patients before and after a course of rehabilitation.
|Percentage distribution of blood counts before and after a course of rehabilitation (relative to normal)|
|No.||Index||The number of patients with index less than normal (%)||The number of patients with index equal to the rate (%)||The number of patients with higher standards (%)|
|1.||The hemoglobin to||2,78||38,89||with 58.33|
|2.||The erythrocytes to||5,55||69,45||25|
|3.||The leukocyte -||2,78||91,67||5,55|
|4.||The neutrophils to||16,67||83,33||-|
|7.||The lymphocytes to||5,55||27,75||22,2|
|9.||The ESR to||-||77,8||22,2|
|10.||Sodium p the following||-||100||-|
|12.||Triglycerides up||43,5||a 21.75||34,78|
|Cholesterol after||4,35||for 91.3||4,35|
|15.||Uric acid to||17,39||65.22 per||17,39|
|Uric acid after||21,7||73,95||4,35|
Based on test results, the detection of the positive dynamics of controlled blood counts, ie was achieved improvement of the patient's body. Complaints about headaches, bowel disorders, disorders of potency was preserved only in 6% of patients. At the same time had seen an overall decrease in the incidence of patients compared with the rest of the population of the areas they live in the next 6 months due to immune modulating and adaptogenic action of the drug.
Evaluation of the effectiveness of rehabilitation in patients with endocrinological disorders (allergic reactions unclear Genesis, trophic ulcers of the lower extremities) were performed in the group of 19 people (men and women). All patients received during the 36 days of the gel from brown algae, obtained by the claimed method, 75±5 g of the gel for 30 minutes before eating in the morning, afternoon and evening. In 7 patients with trophic ulcers used a combination of external and internal use of the gel from marine algae. When this was done rubbing the gel on 15-25 g morning and evening in the area of 1.5-2 cm around the lesions. In 10 patients with allergic reactions of unclear Genesis 10-11 days in patients receiving gel from marine algae disappeared skin itching and rashes on the type of urticaria. In patients with trophic ulcers with 8-12 days there was a trend to their rapid regenerative (epithelization). By the end of the course, all patients who were stationary even more significantly improving the status and conservation, at least 6 months, due to the immunomodulatory effects of the drug.
Thus, a positive dynamics of the patient, i.e. the achieved improvement of the body.
Examples 1-6 and other studies demonstrate a favorable effect of the gel from brown algae according to the present method, its possibilities in regenerative medicine as a means overall health and save health reserve. The negative consequences of not receiving the gel identified, i.e. side effects (which is the basis for establishing contraindications) not found. Healing effect continues for the period of at least three times the duration of the course of treatment.
The gel from brown seaweed, used for healing, is one of the most modern and high quality biologically active products, has adaptogenic and immunomodulatory effects, and improved organoleptic characteristics and minimal likelihood of side effects.
Thus, an effective and inexpensive way of healing the body, as well as expanded the Arsenal of methods of healing the human body.
This extended the range of application for restoration of functions of all major organs, obespecheniyativoli disturbed metabolism, increase the body's resistance to diseases of gastrointestinal tract, cardiovascular and endocrine systems, as well as antioxidant and immunomodulatory actions, with minimal likelihood of side effects, excretion of various toxic substances, such as lead, mercury, cobalt and radioactive elements derived uranium, reducing the time to obtain meaningful results, simplify the process of recovery.
1. The method of healing the body, in which daily patients take oral medication from brown algae, characterized in that at least two times a day before meals for 4-24 weeks take as drug gel from homogenised brown algae with a particle size of not more than 500 μm and the iodine content is not less than 15 mg/kg and carbohydrate fractions: mannat - 133,4±12,1 mg/g, alginic acid - 147,8±10,7 mg/g, in an amount of from 50 to 250 g per day.
2. The method according to claim 1, characterized in that the gel from brown algae are 30±5 minutes before eating.
3. The method according to claim 1, characterized in that the gel from brown algae take in not less than 1 year and not more than 5 g per kilogram of body weight per day.
4. The method according to any one of claims 1 and 2, characterized in that the gel from brown algae, at least two times a day is used in the form of applications on d is unavailable affected areas.
5. The method according to any one of claims 1 and 2, characterized in that the gel from brown algae is produced by processing, including cutting of raw materials, which take fresh thallus brown algae, rhizoids cut off, washed with water and dried, and then washed in fresh water at a temperature of 25-35°for 20-50 min with periodic mixing for uniform swelling, not less than 30%, then make the demineralization of algae which is infused with 0.5%solution of edible acid from the group of acetic, citric or hydrochloric acid having an acidity of pH 2,0, when the mass ratio of the algae and the solution is 1:1.5 and incubated for 1-2 h, after which they are washed from acid in fresh water for 10-12 min and soaked in drinking water at a temperature of 20-35°C for 30-50 min with the change of water during soaking, and after the last washing, give water to flow within 10-20 min, washed algae are crushed and boiled for which pour drinking water with a temperature of 75-85°when the mass ratio of algae and water is 1:1, add sodium bicarbonate until the value of acidity pH 7.0 to 8.0, which is controlled in the cooking process that is carried out within 6-10 hours at a temperature of 70-80°With continuous stirring, and then cooled to 35-45°and homogenize for 3 min, then produce neutralization, which impose solutions of citric acid in an amount of 0.1% and lactate or calcium citrate in an amount of 0.2% by weight of algae, stirred and heated to 75°C.
6. The method according to claim 5, characterized in that as brown algae take seaweed from the group of laminaria and fucus from the basin of the Okhotsk, Bering and Japanese seas.
FIELD: medicine, veterinary science, agriculture, biotechnology.
SUBSTANCE: the present innovation refers to preparations of medicinal and veterinary indication and methods for their obtaining. The suggested complex preparation-probiotic includes a carrier being a porous aluminum oxide-based enterosorbent SUMS-1 and cells of bacteria-eubiotics with nutritive and protective media immobilized upon the mentioned carrier-enterosorbent. The cells of bacteria-eubiotics with nutritive medium are being a lyophilized concentrate of the consortium of either bifidobacteria or lactobacteria, or their mixture at titer being 108-1010 CFU/g, and as a porous carbon-modified enterosorbent SUMS-1 it contains enterosorbent SUMS-1 additionally treated with the solution of metal salt at the following ratio of the preparation components in lyophilized form, weight%: cells with nutritive medium of the consortium of bifido-, or lactobacteria-eubiotics, or their mixture with titer of 108-1010 CFU/g 1.0-10.0; protective medium 0.1-10.0; enterosorbent SUMS-1 additionally treated with the solution of metal salt - the rest up to 100%. Method for obtaining the suggested preparation deals with treating a porous enterosorbent SUMS-1 with the solution of metal salt at volumetric ratio being 1:1, not more and its washing against a reagent with 2-3-fold volumes of distilled water followed by mixing enetrosorbent and bacteria-eubiotics with nutritive and protective media at the ratio of 1:1, not more to keep the mixture till complete immobilization of bacterial cells onto enterosorbent with its subsequent freezing and freeze drying before sterilization. As bacteria one should apply the concentrate of the consortium of bifidobacteria, or lactobacteria, or their mixture at titer being 108-1010 CFU/g. The suggested complex preparation-probiotic provides higher efficiency of sorption and desorption of bacterial cells with enterosorbent SUMS-1 that shows its clinical efficiency and higher colonization activity of bacteria-eubiotics.
EFFECT: higher efficiency.
9 cl, 5 ex, 2 tbl
FIELD: medicine, surgery.
SUBSTANCE: the present innovation refers to treating osseous cavity in patients with chronic post-traumatic osteomyelitis, so, after necrsequestrectomy one should irrigate an osseous cavity with aqueous solution of sodium chloride, then it is necessary to treat the cavity with 3%-hydrogen peroxide solution with subsequent removal of foam with 0.02%-chlorohexidine bigluconate aqueous solution. Then twice during 1 min it is necessary to treat osseous cavity with 0.9%-ozonized sodium chloride solution at ozone concentration being 9000-10000 mgl/l. After that, one should introduce the mixture of anti-infectious chemotherapeutic preparations along with ultrasound cavitation for 3 min at frequency of 40 kHz followed by treating the cavity with the flow of nitrogen monoxide for 5 min at concentration being 5000 mg/cu. m. The innovation enables to increase penetrating capacity of medicinal preparations due to matching the desired mode of cavitary treatment.
EFFECT: higher efficiency of antiseptic treatment.
FIELD: biotechnology, molecular biology.
SUBSTANCE: invention proposes a polynucleotide VEGI-192a encoding polypeptide that inhibits growth of human vascular endothelial cells. Invention describes expressing vector comprising polynucleotide and E. coli cell-host comprising vector. Invention discloses polypeptide encoded by polynucleotide and fused protein based on indicated polypeptide. Invention describes polynucleotide encoding fused protein and expressing vector based on indicated polynucleotide. Invention discloses a pharmaceutical composition used for inhibition of angiogenesis based on polypeptide-inhibitor of growth of human vascular endothelial cells and polynucleotide encoding its. Invention describes therapeutic methods for inhibition of angiogenesis and suppression of tumor growth based on this composition. Invention describes an antibody raised to polypeptide that inhibits growth of human vascular endothelial cells. Using this invention provides novel forms of inhibitor of human growth of vascular endothelial cells and can be used in medicine.
EFFECT: valuable biological and medicinal properties of inhibitor.
27 cl, 27 dwg, 13 tbl, 34 ex
SUBSTANCE: method involves opening pyo-inflammatory focus. Rexod is introduced in addition to basic therapy. Rexod is introduced during the operation or immediately after the operation and then every day once a day intravenously in bolus dose. The drug is introduced during 4-5 days in physiologic saline or in 5% glucose solution at a dose of 0.2 mcg/kg of patient body weight.
EFFECT: enhanced effectiveness of treatment; improved general health state within a short period; reduced oxidation stress; prevented secondary active oxygen forms production.
SUBSTANCE: disclosed is application of Ximedon (N-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine) for treatment and prophylaxis of various intoxication.
EFFECT: preparation of large spectrum of action and inducing effect comparable with Phenobarbital effect.
2 tbl, 13 ex
SUBSTANCE: method involves treating root canals with instruments and preparation containing calcium hydroxide is temporarily placed into the canals several times changing the portion every 2-5 weeks for fresh one. Before introducing fresh portion, the root canals are treated with antiseptic solution in combination with their ultrasonic treatment.
EFFECT: enhanced effectiveness of treatment; stopped inflammatory responses in periodontium tissues; prevented reinfection.
FIELD: medicine, pulmonology.
SUBSTANCE: it is necessary to study initial values of functional reserve ability (FRA) of pulmonary-capillary circulation in %, average pressure value in pulmonary artery (AvPPA) in mm mercury column and daily variability of peak volumetric expiration rate (ΔPVRexp.) in % to calculate the following equation: D=+1.376·FRA-2.087·AvPPA-1.023·ΔPVRexp. At D value being above -25.71 one should predict instable flow of bronchial asthma. The innovation enables to carry out integral evaluation of functional state of pulmonary microcirculation, pressure in pulmonary artery and reactivity of respiratory tract.
EFFECT: higher efficiency and accuracy of prediction.
FIELD: pharmaceutical chemistry.
SUBSTANCE: invention provides water-soluble camptotecine derivatives showing excellent therapeutical activity and retarded release suitable for cancer chemotherapy. High-molecular weight camptotecine derivative has structure wherein carboxylic acid group of block copolymer of polyethylene glycol and polymer containing carboxylic acid group in side chain and being acidic amino acid polymer is linked to phenol hydroxyl group of phenolic camptotecines through ester linkage. Also claimed is high-molecular weight camptotecine derivative of general formula (I): . Preparation method comprises combining carboxylic acid group of above-defined block copolymer with phenol hydroxyl group of phenolic camptotecines through ester linkage in presence of condensation agent. Anticancer drug includes above-defined camptotecine derivative and optionally pharmaceutically acceptable carrier.
EFFECT: augmented choice of anticancer drugs.
9 cl, 2 dwg, 2 tbl, 5 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a method for treatment of nicotine dependence in a person using a medicinal formulation with controlled release (MFCR) comprising 5,8,14-triazatetracyclo[10.3.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene or its pharmaceutically acceptable salt taken in the effective dose, and to a method for reducing adverse effect of this active component. Method involves using MFCR that comprises agents of this active component for its administration to a patient at the rate less about 6 mg/h resulting to administration of at least about 0.1 mg of compound or its salt for 24 h. The initial administration of MFCR results to plasma maximal concentration (Cmax) of active component in average from 10% to 80% of the corresponding Cmax determined for the equal dose of active component in form of bolus with immediate release, and to increasing time of value Cmax in plasma (Tmax) in initial administration in average by 50% relatively to the corresponding Tmax value determined for the equal dose of active component in form of bolus of immediate release. Also, MFCR releases active component in vireo at the rate less 6 mg/h in the dissolving testing using device USP-2 (USA Pharmacopoeia) in order to provide the dissolving time of 50 wt.-% of active component from 1 to 15 h. Indicated agents comprise a tablet with matrix, multi-particles, covered multi-particles or tablet with a cover. Invention provides carrying out the effective treatment of nicotine dependence and without symptoms of adverse effects of active component, in particle, without nausea.
EFFECT: improved method of treatment.
7 cl, 19 tbl, 13 ex
FIELD: medicine; physiotherapy.
SUBSTANCE: method can be used for doing medicinal procedures in hospitals, sanatoria and resorts. Method is based upon preparation and usage of fluid containing biological active matters made of antlers of maral. Patient's body is subject to influence of vapor at temperature of 30°-85°C. Initially water vapor is applied during 5-30 minutes. Vapor has active matters produced when vapor makes contact with herbs or herbs collection and/or aromatic oil. Then patient's body is subject to influence of vapor during 5-30 minutes, which vapor contains fluid in form of aerosol, which aerosol contains biologically active matters produced from antlers of maral. For taking procedure, vapor cabin is used, which cabin is made of two tightly joined sections. Sections are connected together along one side of joint. One section is motionless and it is connected with aroma-phyto-vapor-former by vapor duct. Cabin is provided with opening intended for patient's head. One part of opening is made in part of top horizontal surface of cabin, which part forms movable section together with part of side surface of cabin. Cabin is also provided with seat for patient. Cabin is made in form of barrel provided with vertical axis. Movable section is connected with motionless section along top side of joint and it is mounted for hoist and it keeps to vertical position by means of gas elevator. Container for biological fluid, containing biologically active matters achieved from antler of maral, is connected with device for high-dispersion spraying of fluid. Fluid communicates with cabin by means of pipeline.
EFFECT: improved efficiency of procedures due to usage of biologically active matters.
9 cl, 3 dwg
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to medicinal agents, in particular, to a drug showing antifungal effect prepared as ointment formulation and based on terbinafine hydrochloride. Invention proposes agent possessing antifungal effect and comprising terbinafine hydrochloride, rare-cross-linked polyacrylic acid, nipagin, Tween-80, vaselin oil, propylene glycol, sodium hydroxide and purified water wherein these components are taken in the definite ratio. Also, invention relates to a method for preparing this antifungal agent. Invention provides the high therapeutic effect of agent, increasing storage time, high stability against oxidation, high tropicity to skin and low cost.
EFFECT: improved and valuable medicinal and pharmaceutical properties of agent.
5 cl, 14 tbl, 3 ex
FIELD: medicine, ophthalmology, pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to a composition used in treatment of demodecoseous blepharitis and blepharoconjunctivitis as a gel or ointment. The composition comprising common wormwood extract prepared by supercritical fluid extraction with carbon dioxide involves the following components, %: terpenes and terpenoids, up to 19; flavonoids, up to 9; steroids, up to 11; vitamins A and E, up to 1; wax, up to 60, and pharmaceutically acceptable filling agent wherein components are taken in the definite amounts. The composition promotes to effective treatment of demodecoseous blepharitis and blepharoconjunctivitis, decreases the treatment period and prolongs inter-relapse period. Proposed composition is used in treatment of patients with demodecosis.
EFFECT: enhanced effectiveness and valuable medicinal properties of composition.
3 cl, 1 tbl, 6 ex
SUBSTANCE: the present innovation deals with applying ambroxol and its acceptable salts for obtaining the medicinal preparation indicated for treating pains in oral cavity and pharynx.
EFFECT: higher efficiency of therapy.
5 cl, 2 dwg, 6 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a composition used in treatment of hemorrhoids, in particular, to composition representing ointment consisting of a mixture of antiseptic and bactericidal gentian-violet (methylrosaniline) and a lubricating substance, in particular, vaseline known as petrolatum also. Proposed composition comprises a suppository also. The composition can be applied easily and shows sedative and healing effect on swollen hemorrhoids and, especially, in bleeding hemorrhoids.
EFFECT: valuable medicinal properties and enhanced effectiveness of composition.
12 cl, 6 ex
FIELD: medicine, dermatology, pharmacy.
SUBSTANCE: invention relates to an ointment acaricide composition used in treatment of demodecosis in humans and comprising salicylic acid, zinc oxide, sulfur, tar, turpentine, lanolin, vaselin and paraffin. Also, invention relates to a method for treatment of demodecosis by every day applying the proposed ointment on damages skin sites by cutaneous route followed by removal ointment from skin and the following immediate using 13-cis-retinoic acid-containing drugs for 3-6 months. Proposed ointment possesses high stability and effectiveness.
EFFECT: improved and valuable medicinal and pharmaceutical properties of composition.
5 cl, 10 tbl
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a pharmaceutical composition possessing anti-inflammatory and analgesic effect. The pharmaceutical composition comprises sodium diclofenac and combination of propylene glycol and ethyl alcohol as organic solvents taken in the mass ratio = 1:(4.05-6.15), and carbomer, dietanolamine, vaseline oil, cocoyl caprylate, macrogol cetostearyl ester, aromatic oil and water as accessory substances. Also, invention relates to a method for preparing the pharmaceutical composition. The composition is stable during storing, it doesn't show irritating effect and elicits high anti-inflammatory and analgesic activity.
EFFECT: improved and valuable medicinal properties of pharmaceutical composition.
7 cl, 1 tbl, 4 ex
FIELD: pharmaceutical industry.
SUBSTANCE: claimed method includes preparation of Arespole oily disperse in rotor-pulsing apparatus at rate 2900-3100 rpm for 4-6 min at (20±5)°C; ground pharmaceutical agent with particle size of 100 mum or less is introduced and mixture is dispersed at the same rate for 3 min followed by neutralization of obtained disperse with sodium hydroxide aqueous solution at rate of 1500 rpm for 3-4 min.
EFFECT: accelerated method for ointment production; increased bioavailability of pharmaceutical agents.
2 tbl, 2 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to creature of ointment for external using. The proposed ointment used for treatment of degenerative-dystrophic diseases of locomotor system comprises vegetable as a fatty product, wax as a bee product, heparin as anticoagulant of direct effect, and glycerol, hydrocortisone and dimethylsulfoxide also. After applying ointment the method involves effect by ultrasound with frequency 88 MHz, power 0.4 Wt/cm2 for 10-15 min. Treatment course is 10-15 procedures. Ointment has no adverse complications, it activates metabolic processes in joint region, improved microcirculation and recovers cartilage surface.
EFFECT: improved and valuable properties of ointment.
1 tbl, 2 ex
FIELD: medicine, chemical-pharmaceutical industry.
SUBSTANCE: invention relates to an antiviral agent as gel. Agent comprises human leukocyte interferon and 2-% solution of styrene copolymer and maleic anhydride as gel-forming base in the following ratio of the agent components, in 1 g of the agent: concentrated interferon, 5000-10000 IU; nipagin, 0.002-0.004 g and a base, the balance. Proposed agent possesses high activity, nontoxic and possesses antiviral, immunomodulating, anti-inflammatory and regenerative effects and can be used in ophthalmology, dermatology, gynecology and surgery for topical using and in treatment of viral diseases.
EFFECT: valuable medicinal properties of agent.
2 tbl, 2 ex
FIELD: medicine, pharmacy, cosmetics.
SUBSTANCE: invention relates to pharmaceutical or cosmetic composition used against insect bites. Proposed composition comprises a soluble salt or mixture of soluble salts of one or some rare-earth elements, triethylene glycol, glycerol, ethyl alcohol, polyethylene oxide, sodium (potassium) hydroxide and purified water. The combination of components taken in the definite ratio provides the creature of pharmaceutical or cosmetic composition preventing itch and topical response in sting of insects. The composition has no biodamaging effect, odor, allergic responses and discomfort state, drying skin effect. The composition can be easily and uniformly distributed on skin being immediately after its applying on skin and without any traces on skin. Proposed compositions can be used for applying on eye regions, lips, mouth cavity and throat mucosa of humans or animals, on regions of insect stings, in particular, mosquito, wasps, gadflies and other insects.
EFFECT: enhanced effectiveness of compositions.
1 tbl, 12 ex
SUBSTANCE: claimed biologically active stimulator contains alcohol extract from mixture of Echinacea purpurea grass and inflorescences, foalfoot, small-leaved linden flowers, and liquorice roots taken in equal amounts. To enhance non-specific resistance calves in addition to injection of non-specific immunoglobuline are ordered to extract in form of 7-8 % water solution in dose of 2.5-3.0 ml per 1 kg of animal mass for 10-15 days with 24 h interval.
EFFECT: non-toxic and environmentally friendly agent of increased effectiveness.
2 cl, 3 tbl, 3 ex