Method for treating osseous cavity after necrsequestrectomy
FIELD: medicine, surgery.
SUBSTANCE: the present innovation refers to treating osseous cavity in patients with chronic post-traumatic osteomyelitis, so, after necrsequestrectomy one should irrigate an osseous cavity with aqueous solution of sodium chloride, then it is necessary to treat the cavity with 3%-hydrogen peroxide solution with subsequent removal of foam with 0.02%-chlorohexidine bigluconate aqueous solution. Then twice during 1 min it is necessary to treat osseous cavity with 0.9%-ozonized sodium chloride solution at ozone concentration being 9000-10000 mgl/l. After that, one should introduce the mixture of anti-infectious chemotherapeutic preparations along with ultrasound cavitation for 3 min at frequency of 40 kHz followed by treating the cavity with the flow of nitrogen monoxide for 5 min at concentration being 5000 mg/cu. m. The innovation enables to increase penetrating capacity of medicinal preparations due to matching the desired mode of cavitary treatment.
EFFECT: higher efficiency of antiseptic treatment.
The invention relates to medicine, namely to the field of surgical treatment of chronic diseases, post-traumatic osteomyelitis.
Pyo-inflammatory processes occupy a leading place in the structure of morbidity and mortality. Especially notable among them by severity, diagnostic difficulties and adverse outcomes of chronic post-traumatic osteomyelitis.
Today surgical treatment is the primary and most effective in the treatment of this pathology.
Radical surgery itself involves not only the removal of osteomyelitis focus per se, but also the elimination of favorable conditions for the existence of infection. The most important element operative intervention is necrsequestrectomy with subsequent grafting postoperative cavity. Consequently, high-quality training cavity before grafting the graft is one of the necessary conditions for a successful and effective treatment.
There is a method of treatment of the wound by washing with sea water, wrapping and subsequent suturing .
The disadvantage of this method is the relatively high number of recurrent osteomyelitis after treatment of bone cavities sea water.
However, application of this method does not exclude the possibility of postoperative complications and does not reduce the healing time of the wound.
There is a method of treatment of purulent-inflammatory wounds by surgical treatment and rinsing with an antiseptic solution applied to the surface of the wound in the form of a vortex flow .
The disadvantage of this method is the low efficiency of the treatment.
A method of processing bone cavity with a solution of antiseptic liquid, for example with furatsilina .
The disadvantage of this method is the low penetration ability in the bone tissue and often the lack of bactericidal activity in the bone cavity.
There is a method of treatment of the wound by irrigation water solution of a drug and subsequent suturing. Moreover, as the medicinal product applied solution of sodium chloride with a concentration of from 3.0 to 3.2% .
The disadvantage of this method is low efficiency antiseptic treatment of bone processing after sequestrectomy.
The aim of the invention is to improve the effectiveness of the antiseptic treatment of bone cavities after necrsequestrectomy.
This goal is achieved by the fact that after irrigation aqueous solution of sodium chloride cavity treated with 3% solution of p is rekishi hydrogen, remove the foam 0.02% aqueous solution of chlorhexidine digluconate, twice within 1 minute ozonated process with 0.9% sodium chloride solution with a concentration of ozone 9000-10000 MGL/l was injected into the cavity solution of anti-infective chemotherapeutic agents with simultaneous ultrasonic cavitation for 3 minutes with a frequency of 40 kHz and handle cavity flow monoacid nitrogen for 5 minutes with a concentration of 500 mg/m3.
Comparison of proposed method with other solutions known in the field of medicine, has demonstrated its compliance with the criteria of the invention.
The proposed method of processing bone cavity after necrsequestrectomy is implemented as follows.
Place the solution of sodium chloride declared concentration in the vial 200-400 ml and saturate it by barbotage ozone-oxygen mixture for 5-10 minutes with ozone concentration 9000-10000 IPF/L. Bone cavity is irrigated with an aqueous solution of sodium chloride with a concentration of 0.9%, and then treated with 3% hydrogen peroxide solution, remove the foam 0.02% aqueous solution of chlorhexidine digluconate, twice within 1 minute ozonated process with 0.9% sodium chloride solution, which was already prepared, injected into the cavity solution of anti-infective chemotherapeutic agents with simultaneous ultrasonic cavitation within 3 mine is with a frequency of 40 kHz and process cavity flow monoacid nitrogen for 5 minutes with a concentration of 500 mg/m 3.
Clinical example. Patient N., 35 years old, diagnosed with chronic post-traumatic osteomyelitis of the left tibia. Performed necrsequestrectomy. The dimensions of the cavity 50×20×8 ml, manufactured irrigation water solution of sodium chloride with a concentration of 0.9%, then treatment with 3% hydrogen peroxide solution, the foam was removed 0.02% aqueous solution of chlorhexidine digluconate in subsequent cavity twice within 1 minute was treated with ozonated 0.9% sodium chloride solution, introduced into the cavity of a solution of anti-infective chemotherapeutic agents with simultaneous ultrasonic cavitation for 3 minutes with a frequency of 40 kHz and processed cavity flow monoacid nitrogen for 5 minutes with a concentration of 500 mg/m3. The size of the bone cavity was prepared graft and replaced them with postoperative cavity. Layers left the house taking the wound tightly. The wound healed by first intention after one week with good distant result.
The use of the proposed method can improve the effectiveness of the antiseptic treatment of bone cavities after necrsequestrectomy, which in turn reduces the treatment time.
The use of the proposed method is reasonable in purulent surgical departments of medical institutions for the treatment of chronic posttraumatic osteomyelitis of the Horno musculoskeletal system.
Sources of information
1. Shakhnazarov A.B., Lukasz IV Sea water and its therapeutic application. M.: Medicine, 1966. P.40-41.
2. Pods VI and other Purulent wound. M.: Medicine, 1975. S-289.
3. Auth. mon. The USSR №1593631, CL AV 17/00, 1990.
4. Khomich LI Chronic osteomyelitis. Minsk, 1977. S.
5. Auth. mon. The USSR №1109168, CL 61K 33/14, 1984.
The method of processing bone cavity after necrsequestrectomy by irrigation water solution of sodium chloride, characterized in that after irrigation aqueous solution of sodium chloride cavity treated with 3%hydrogen peroxide solution, remove the foam of 0.02%aqueous solution of chlorhexidine digluconate, twice for 1 min ozonated process of 0.9%sodium chloride solution with a concentration of ozone 9000-10000 MGL/l was injected into the cavity solution of anti-infective chemotherapeutic agents with simultaneous ultrasonic cavitation for 3 min with a frequency of 40 kHz and handle cavity stream of nitrogen monoxide for 5 min with a concentration of 500 mg/m3.
FIELD: biotechnology, molecular biology.
SUBSTANCE: invention proposes a polynucleotide VEGI-192a encoding polypeptide that inhibits growth of human vascular endothelial cells. Invention describes expressing vector comprising polynucleotide and E. coli cell-host comprising vector. Invention discloses polypeptide encoded by polynucleotide and fused protein based on indicated polypeptide. Invention describes polynucleotide encoding fused protein and expressing vector based on indicated polynucleotide. Invention discloses a pharmaceutical composition used for inhibition of angiogenesis based on polypeptide-inhibitor of growth of human vascular endothelial cells and polynucleotide encoding its. Invention describes therapeutic methods for inhibition of angiogenesis and suppression of tumor growth based on this composition. Invention describes an antibody raised to polypeptide that inhibits growth of human vascular endothelial cells. Using this invention provides novel forms of inhibitor of human growth of vascular endothelial cells and can be used in medicine.
EFFECT: valuable biological and medicinal properties of inhibitor.
27 cl, 27 dwg, 13 tbl, 34 ex
SUBSTANCE: method involves opening pyo-inflammatory focus. Rexod is introduced in addition to basic therapy. Rexod is introduced during the operation or immediately after the operation and then every day once a day intravenously in bolus dose. The drug is introduced during 4-5 days in physiologic saline or in 5% glucose solution at a dose of 0.2 mcg/kg of patient body weight.
EFFECT: enhanced effectiveness of treatment; improved general health state within a short period; reduced oxidation stress; prevented secondary active oxygen forms production.
SUBSTANCE: disclosed is application of Ximedon (N-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine) for treatment and prophylaxis of various intoxication.
EFFECT: preparation of large spectrum of action and inducing effect comparable with Phenobarbital effect.
2 tbl, 13 ex
SUBSTANCE: method involves treating root canals with instruments and preparation containing calcium hydroxide is temporarily placed into the canals several times changing the portion every 2-5 weeks for fresh one. Before introducing fresh portion, the root canals are treated with antiseptic solution in combination with their ultrasonic treatment.
EFFECT: enhanced effectiveness of treatment; stopped inflammatory responses in periodontium tissues; prevented reinfection.
FIELD: medicine, pulmonology.
SUBSTANCE: it is necessary to study initial values of functional reserve ability (FRA) of pulmonary-capillary circulation in %, average pressure value in pulmonary artery (AvPPA) in mm mercury column and daily variability of peak volumetric expiration rate (ΔPVRexp.) in % to calculate the following equation: D=+1.376·FRA-2.087·AvPPA-1.023·ΔPVRexp. At D value being above -25.71 one should predict instable flow of bronchial asthma. The innovation enables to carry out integral evaluation of functional state of pulmonary microcirculation, pressure in pulmonary artery and reactivity of respiratory tract.
EFFECT: higher efficiency and accuracy of prediction.
FIELD: pharmaceutical chemistry.
SUBSTANCE: invention provides water-soluble camptotecine derivatives showing excellent therapeutical activity and retarded release suitable for cancer chemotherapy. High-molecular weight camptotecine derivative has structure wherein carboxylic acid group of block copolymer of polyethylene glycol and polymer containing carboxylic acid group in side chain and being acidic amino acid polymer is linked to phenol hydroxyl group of phenolic camptotecines through ester linkage. Also claimed is high-molecular weight camptotecine derivative of general formula (I): . Preparation method comprises combining carboxylic acid group of above-defined block copolymer with phenol hydroxyl group of phenolic camptotecines through ester linkage in presence of condensation agent. Anticancer drug includes above-defined camptotecine derivative and optionally pharmaceutically acceptable carrier.
EFFECT: augmented choice of anticancer drugs.
9 cl, 2 dwg, 2 tbl, 5 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a method for treatment of nicotine dependence in a person using a medicinal formulation with controlled release (MFCR) comprising 5,8,14-triazatetracyclo[10.3.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene or its pharmaceutically acceptable salt taken in the effective dose, and to a method for reducing adverse effect of this active component. Method involves using MFCR that comprises agents of this active component for its administration to a patient at the rate less about 6 mg/h resulting to administration of at least about 0.1 mg of compound or its salt for 24 h. The initial administration of MFCR results to plasma maximal concentration (Cmax) of active component in average from 10% to 80% of the corresponding Cmax determined for the equal dose of active component in form of bolus with immediate release, and to increasing time of value Cmax in plasma (Tmax) in initial administration in average by 50% relatively to the corresponding Tmax value determined for the equal dose of active component in form of bolus of immediate release. Also, MFCR releases active component in vireo at the rate less 6 mg/h in the dissolving testing using device USP-2 (USA Pharmacopoeia) in order to provide the dissolving time of 50 wt.-% of active component from 1 to 15 h. Indicated agents comprise a tablet with matrix, multi-particles, covered multi-particles or tablet with a cover. Invention provides carrying out the effective treatment of nicotine dependence and without symptoms of adverse effects of active component, in particle, without nausea.
EFFECT: improved method of treatment.
7 cl, 19 tbl, 13 ex
FIELD: medicine; physiotherapy.
SUBSTANCE: method can be used for doing medicinal procedures in hospitals, sanatoria and resorts. Method is based upon preparation and usage of fluid containing biological active matters made of antlers of maral. Patient's body is subject to influence of vapor at temperature of 30°-85°C. Initially water vapor is applied during 5-30 minutes. Vapor has active matters produced when vapor makes contact with herbs or herbs collection and/or aromatic oil. Then patient's body is subject to influence of vapor during 5-30 minutes, which vapor contains fluid in form of aerosol, which aerosol contains biologically active matters produced from antlers of maral. For taking procedure, vapor cabin is used, which cabin is made of two tightly joined sections. Sections are connected together along one side of joint. One section is motionless and it is connected with aroma-phyto-vapor-former by vapor duct. Cabin is provided with opening intended for patient's head. One part of opening is made in part of top horizontal surface of cabin, which part forms movable section together with part of side surface of cabin. Cabin is also provided with seat for patient. Cabin is made in form of barrel provided with vertical axis. Movable section is connected with motionless section along top side of joint and it is mounted for hoist and it keeps to vertical position by means of gas elevator. Container for biological fluid, containing biologically active matters achieved from antler of maral, is connected with device for high-dispersion spraying of fluid. Fluid communicates with cabin by means of pipeline.
EFFECT: improved efficiency of procedures due to usage of biologically active matters.
9 cl, 3 dwg
FIELD: biotechnology, immunology, biochemistry, medicine.
SUBSTANCE: invention proposes peptide concatemer inducing production of antibodies against apolipoprotein B-100 that inhibit lipase effect and inhibit binding LDL with LDL receptors. This concatemer consists of amino acid sequence of peptide repeating four times. Amino acid sequence is given in the invention description. Also, invention describes a concatemer-base vaccine used in treatment and prophylaxis of obesity and a method for preparing concatemer in E. coli cells using a vector. Invention discloses a polynucleotide encoding concatemer and expressing vector comprising the indicated polynucleotide. Using the invention provides inhibition of obesity.
EFFECT: valuable medicinal properties of concatemer and vaccine.
7 cl, 16 dwg, 1 tbl, 6 ex
SUBSTANCE: it is necessary to fulfill total body heating at preliminary intramuscular injection of a substance that increases the resistance to hyperthermia. The substance mentioned is represented by zootoxin. The innovation provides increased body resistance to hyperthermia and body survival rate.
EFFECT: higher efficiency of controlled hyperthermia.
4 cl, 1 tbl
FIELD: medicine, in particular, means for stimulating influence upon biological tissue parts.
SUBSTANCE: method involves providing action of ultrasonic and magnetic waves upon biological tissue parts by creating around selected tissue part of external magnetic field at variable first frequency, and by influencing upon said tissue part of ultrasonic waves focused thereon at variable second frequency, for generating therein electric current resulted from mechanical vibratory motion of this tissue part under the influence of ultrasonic waves. Apparatus for effectuation of said method has source for creating of external magnetic field variable at first frequency, source of ultrasonic waves variable at second frequency, device for focusing of ultrasonic waves on said part of organism tissue for generation therein of electric current resulted from mechanical vibratory motion performed by said part of tissue under the influence of ultrasonic waves.
EFFECT: increased stimulating effect due to generation of current in selected part of tissue upon local excitation of mechanical vibratory motion in magnetic field.
10 cl, 3 dwg, 1 ex
SUBSTANCE: method involves treating injured joint and healthy one with 3% Diquertine solution. Next, ultrasonic treatment is applied. The treatment is carried out in contact way in pulsating mode with 2-4 ms long pulse durations. Treatment time is 4-5 min per each joint. The daily treatment course is 7-10 procedures long.
EFFECT: enhanced effectiveness of treatment; reduced drug consumption.
FIELD: medicine, pediatrics.
SUBSTANCE: the present innovation deals with treating children aged 12-15 in case of primary arterial hypertension. After a 5-d-long adaptation period it is necessary to carry out ultrasound inhalations with low-mineralized hydrocarbonate-chloride sodium-boron mineral water "Lazarevskaya" every other day. Aerosol flow rate corresponds to 5 l/min, duration being 3 min. Then it is important to carry out inhalations with peach or other kernel-fruit oils in combination with laserotherapy for 7 min, cutaneously above left cubital vein, at impulse frequency being 80 Hz followed by a 5-min-long impact onto reflexogenically-segmental areas C VII-VIII-ThIV from the left onto cardiac area from spinal side and onto cervico-brachial area at impulse frequency being 3000 Hz, impulse power being 2 W. During days free from inhalations and laserotherapy it is necessary to take general hydrogen sulfide baths: for boys at concentration of hydrogen sulfide of the first bath - 50 mg/l, the next - 100 mg/l and for girls - at concentration of hydrogen sulfide 25-50 mg/l. The course consists of 10 inhalations, 10 laserotherapeutic procedures and 8 balneoprocedures. The innovation increases adaptational body abilities and increases body tolerance to physical loadings.
EFFECT: higher efficiency of therapy.
2 ex, 3 tbl
SUBSTANCE: method involves concurrently applying rhythmic coherent luminous, acoustic and vibrotactile actions built in functional frequency bandwidth of bioelectrical human brain activity. Coherently bound luminous, acoustic and vibrotactile actions are implemented on harmonic oscillation grid derived from base frequency by multiplying it. Luminous action is carried out on base frequency. Acoustic and vibrotactile actions are based on base frequency or its harmonics.
EFFECT: enhanced effectiveness of combined treatment with action results predictable in advance.
4 cl, 1 dwg, 7 tbl
FIELD: medical equipment.
SUBSTANCE: device can be used for treating hollow organs in gynecology and proctology. Device has cylindrical case with distal oval-shaped end. Channel for pumping working medium in is made in distal end. Channel is connected with unit for pumping of working medium in. Cylindrical case is placed into elastic envelope. One end of envelope is closed and the other one is connected fastened at its circular groove. Channel for pumping working in is connected by recesses with circular grooves made onto side surface of cylindrical case.
EFFECT: improved medicinal effect; preservation of medicinal preparation during process for introduction of device into abdominal cavity.
5 cl, 1 dwg
FIELD: medical engineering.
SUBSTANCE: device has control unit, ultrasonic converter transmitting ultrasonic wave to target area for treating patient, focusing unit so that the ultrasonic converter and focusing unit are enclosed into handheld ultrasonic applicator. An additional device has cooling means having water tank connected to tube system passing through the handheld ultrasonic applicator. The water tank and tubes form closed circuit.
EFFECT: improved serviceability in treating skin injuries.
34 cl, 6 dwg
SUBSTANCE: method involves exposing myocardium to ultrasonic oscillations having frequency of 100-300 kHz and power of 250-270 J/cm2.
EFFECT: low invasiveness; reduced risk of significant adverse side effects; enabled preconditioning in polyclinic.
3 cl, 4 dwg
SUBSTANCE: method involves paravertebrally applying combined photo- and vacuum treatment in red and infrared bandwidth to segmental region in accordance to injury intensity. First, stable treatment method is applied with vacuum parameters of 25-28 kPa during 2-4 min. Then, labile treatment method is applied with vacuum parameters of 18-20 kPa during 8-10 min. Next, ultrasonic treatment is applied without time interval to appropriate segmental region in pulsating mode with pulse duration of 20 ms, action intensity of 0.4-0.6 W/cm2 daily during 2-8-min. The total treatment course is 10 procedures long.
EFFECT: alleviated or blocked pain syndrome manifestations; lowered sensory disorders level; improved peripheral blood circulation and tissue trophism; marked anesthetic, neurotrophic and spasmolytic action.
FIELD: medical engineering.
SUBSTANCE: device has thermoelectric modules, radiators making temperature contact with supporting soldered joints having working joints making thermal contact to plate-like applicator. Each radiator has a set of disks fitted on heat-conducting axle, the disk diameters reducing towards the axle end. Each makes temperature contact to supporting soldered joints via piezo-electric element. The radiators are immersed into paraffin filling the casing. The applicator is metal plate one surface of which has saw-like protrusions. The module is pressed into flexible membrane. Each thermoelectric module is connected to multi-channel power supply source. Two casings connected with hinges to elastic metal plate form paired head phone.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: it is necessary to fulfill ultrasound treatment of the wound with perfluoran twice or thrice per about 3060 sec. The it is important to apply a perfluoran-containing bandage for about 3-4 d. For the purpose to avoid drying of this bandage it is necessary to install there a thin catheter through which, by fractions, one should introduce perfluoran 3-4 times daily. The innovation accelerates the process of wound purification, improves tissue reparation due to efficient tissue oxygenation and, thus, develop a slightly visible cosmetic cicatrix.
EFFECT: higher efficiency of therapy.
FIELD: medicine; radiological diagnostics.
SUBSTANCE: method can be used for diagnosing endometriosis of uterus and for estimating state of post-operational scars of myometrium as well as for visualizing bases of subserous and submucous myomatous uterus nodes. Uterus cavity is filled with contrast matter. Hydrogen peroxide solution is used as contrast matter in non-toxic amount; solution is injected in bolus dosing. Before injection sizes of uterus cavity are measured additionally and expected limiting volume V of filling of uterus cavity is calculated from relation of V=0,1a1h2, where h is length of uterus cavity, and a1 is width of uterus cavity at bottom of uterus. In accordance with expected limiting volume of filling, amount of injected echo-contrast matter is chosen while taking its rejection along uterus tubes into account. Uterus cavity is filled in dosage-by-dosage to make sure that there is no drainage of matter trough uterus neck and limiting volume of filling of cavity is kept. Appearance of echo-contrast matter is scars of myometrium, in myometrium, onto parietal and visceral peritoneum is estimated at moment of injection of contrast matter or later.
EFFECT: improved precision of inspection.
4 l, 16 dwg, 4 ex