Method for treating female tubo-peritoneal sterility cases after plastic reconstruction operations

FIELD: medicine.

SUBSTANCE: method involves applying therapy course containing iodine-bromine baths and vaginal irrigations given every other day. Electrophoresis is administered in days free of baths and irrigations after 2 adaptation days with silt mud enriched in hydrogen sulfide water containing hydrogen sulfide in concentration of 350 mg/l. The treatment is applied to hypogastric and lumbosacral region at the level of L4-S2 vertebrae. Electric current intensity is equal to 0.05-0.1 MA/cm2 during 20 min. The total treatment course is 8 balneo- and physioprocedures long.

EFFECT: reduced peritoneal commissure process intensity; normalized vegetative nervous system and ovarian functions; improved cellular and humoral immunity; increased female fertility.

5 tbl

 

The invention relates to medicine, namely to gynecology, and can be used in medical practice for the treatment of women suffering from inflammatory diseases of genitals, complicated infertility, and after reconstructive operations on the female genital organs.

Currently, the problem of infertility caused by tubal obstruction on the background of adhesions in the field of appendages after suffering inflammatory diseases of the pelvic organs (PID) in women and its treatment is one of the most important in gynecology. The analysis of literature data shows that in recent years there has been a tendency to increase in the weight of reconstructive gynecological surgery in the treatment of infertility. However, the number coming after operations on fallopian tubes pregnancies is, according to different sources, from 18 to 48%, which is associated with development of postoperative adhesions, the imbalance in the Central and peripheral parts of the system of regulation of the reproductive system. Therefore, the search for methods that increase the efficiency of surgical treatment of infertility is current, and according to most authors, this method is restorative physical therapy.

Know the application of various physical factors after laparoscopic is piracy on the fallopian tubes, in particular bromine balneotherapy as public baths and vaginal lavage (Lasalista, Lpereira "Physical agents in rehabilitation of patients after surgery on the fallopian tubes", W-l "Matters. kurortol". - 1995. No. 1. - P.17-19) and pelotherapy - use applications of peat on "trusilova zone (Diamond I.I. "Mechanical and electromagnetic oscillations in rehabilitation of women after surgery on the fallopian tubes", abstract of Cand. Dr. med. Sciences, 2004).

However, their use in these patients improves the condition of the internal genital organs, the circulation of the blood in the vascular pool pelvis, hormonal status, but does not allow you to attain the parameters characteristic of a healthy woman.

In sanatorium-resort treatment of inflammatory diseases of female pelvic organs applied enriched hydrogen sulfide water silt mud Imereti field (Recreation resources. The monograph. 2 So, Ed. Neammanee. - Publishing house of Rostovs. University, 1980, Vol 1. Spa treatment factors and resources. - 311 S.)

However, the use of this silt mud, enriched hydrogen sulfide water, by electrophoresis on a region of the uterus and its appendages in women after reconstructive operations regarding tubal-peritoneal infertility has not previously been used.

Silt mud, bohadana sulphurous water, refers to the variety of sulfide silt moderately mineralized sulfide-poor muds. The base mud is mixed natural silts with mineral water with the concentration of hydrogen sulfide 350 mg/l by its chemical compound with the moving forms of ferrous and ferric iron contained in the silts in large numbers (up to 7% by weight), and subsequent sedimentation and compaction of newly formed sulfide mud to a pastelike consistency. The resulting hydroservice iron envelops silt particles, gaseous hydrogen sulphide mineral water saturates the sludge solution and solid phase, and partially oxidized sulfide is transformed into colloidal sulfur. The salinity of the mud solution is determined by the composition used to enrich the original silt mineral water is more than 25 g/DM3and a stable value. Visually mud is a uniform, compacted to the pasty consistency of the mass is dark grey, almost odourless. Humidity dirt more than 60%, the specific gravity of 1.33 g/cm3the shear 2300 Dyne/cm2. The heat capacity becomes equal to 0.73 feces, heat-retaining capacity of up to 500 C. the Clogged dirt particle size of 0.25-0.50 mm is 0.2%. Mineral is e inclusions larger than 5.0 mm no. Clay frame exceeds 60% of dry matter. The colloidal complex is more than 30% of the dry matter of the mud. All this allows to read the data of dirt finely dispersed and highly plastic. The pH of the mud - 6,7; redox potential is 130 mV, i.e. dirt is close to neutral environment and the reduction conditions. The content of iron sulfides - 0,17% mg per raw dirt. In the solution are present in appreciable quantities bromo - 60 mg/DM3boric acid is more than 100 mg/DM and a small amount of iodine, 10 mg/DM3. These components are biologically active and useful when using mud. The composition of the microflora of curative mud characteristic of natural peloids and several distinguished by the absence of bacteria involved in the sulfur cycle. Sanitary-epidemiological indicators fully meet the set standards.

Closest to the proposed method is a method of rehabilitation treatment of patients undergoing surgery on the fallopian tubes, by bromine balneotherapy as public baths and vaginal irrigation, temperature 36°C, the duration from 10 to 15 minutes, in the course of 10-12 treatments (Lasalista, Lpereira "Physical agents in rehabilitation of patients after surgery on the fallopian tubes", - kurortol. - 1995. No. 1. - P.17-19).

The task of the invention is to improve therapeutic efficacy by reducing adhesions, the disappearance of pelvic pain, normalize the function of the autonomic nervous system and the function of the ovaries, increase nonspecific resistance, normalization of cellular and humoral immunity, reducing the activity of SEX, increase fertility in women after reconstructive plastic surgery with tubal-peritoneal infertility.

Problem solving is achieved by the fact that after two days of adaptation assign electrophoresis silt mud, enriched with sulphurous water in hydrogen sulfide concentration of 350 mg/l, the area of the appendages on madonnamarlee methodology, the current strength of 0.05 - 0.1 mA·cm220 minutes a day with total iodide-bromine baths and vaginal irrigation, 10-15 minutes. Course 8 balneotherapy and physiotherapy.

The method is as follows.

From the third day from receipt of the patient is prescribed electrophoresis silt mud on the region hypogastric and lumbosacral region at the level of L4-S2 vertebrae duration of 20 minutes. The next day, spend vaginal irrigation bromine water, the temperature of 39-40°C for 15 minutes (first 10 minutes). 15-20 minutes after vaginal arose the Oia woman takes the total bromine baths when water temperature is 36-37° With a duration of 15 minutes (first 10 minutes) in a day on the course by 8 balneotherapy and physiotherapy (table 2).

Table 2
The scheme of leave procedures of the proposed method.
Days of treatmentElectrophoresis of mud is rich in sulphurous water in hydrogen sulfide concentration of 350 mg/l, the current 0,05-0,1MA cm2Bromine balneotherapy (time in min)
MinSheaths. irrigation, temperature 39-40°CShared bath, the temperature of 36-37°C
1-2Adaptation tests.
320
4-1010
520
61515
720
81515
920
101515
11 20
121515
1320
141515
1520
161515
1720
181515

Preparation of dirt. Dirt from the standard package put in the right amount in a glass jar with a wide neck, which is tightly closed by a lid, and placed in a thermostat (or water bath) and is brought to a temperature of 39°C. the Remaining packing the dirt is stored under a layer of hydrogen sulphide water. Before you leave procedures dirt in the amount of 200-250 g level a uniform layer thickness of not less than 1 cm, in the center deployed linen napkins size : 16 × 14 see

The free ends of the napkin folded over, forming the envelope gasket. The fabric envelope-strip spontaneously impregnated with the liquid fraction of the dirt is moist and well organized for the electric current. The patient lies on the couch on his back. On the lumbosacral about the art place mud envelope-layer part to the body, on it place the electrode and washer, oil cloth. Similar mud envelope place Nagano, on top of it put the electrode pads oilcloth and a bag of sand. For a vacation procedures use the "Thread-1" and the electrodes with an area of 12 × 14 see the Electrode with the sign (-) is placed Nagano. Current set in the range of 0.05-0.1 MA·cm2and regulate individual feelings of the patient. The procedure duration is 20 minutes. On completion of envelopes with dirt are removed and the affected area, if necessary, dry cloth. The return mud is utilized. Cloth rinsed in running water, boil for at least 10 minutes, wring out in a centrifuge and dried.

Example. Patient M., aged 26, was on treatment in gynecological clinic SIC Cyrus CSUS health Ministry with 29.07. on 21.08.2003, history No. 1686). Upon admission to the clinic complaining of recurrent pain in the lower abdomen, aggravated by hypothermia, irritability, tearfulness, lack of pregnancy for 1.5 years.

From the anamnesis. For the first time inflammation of the appendages was diagnosed in 1998 after cooling. Exacerbation of the inflammatory process was not. In 2001 he applied for infertility revealed obstruction of pipes according to hysterosalpingography. Regularly 2-3 times per year received rasasi the expansion therapy. In 2002 came a tubal pregnancy, during laparoscopic surgery, the tube was stored. After the operation was also carried out absorbable therapy, but without effect. In April 2003, conducted laparoscopic reconstructive surgery, during which was restored patency of the tubes. In the early postoperative period, the woman received the magnet on the area of the appendages. According to rectal thermometry identified the luteal phase deficiency. Upon admission to the hospital after examination, she was diagnosed with the Condition after reconstructive plastic surgery (postoperative adhesions bilateral). Ovarian dysfunction (NLF). Infertility II.

Before treatment. Complete blood count: HB - 137,8 g/l, erythrocytes - 4,9×1012/l printing. the index is 0.84%, leucocytes - 9,8×109/l, ESR - 6 mm/h, segmented neutrophils - 53%, stab neutrophils - 2%, eosinophils - 1%, monocytes - 5%, lymphocytes - 39%. Urinalysis is within normal limits.

The immunological: leukocytes - 6.4 thousand/µl lymphocytes - 30% - 1920/µl, monocytes - 6%, T-lymphocytes - 60% - 1152,0/µl, b-lymphocytes - 15% - 288,0/ál, T-helpers - 29% - 556,8/ál, T-suppressors - 31% - 595,2/µl, immunoregulatory index (IRI) - 0,93, SLO - tracks, immunoglobulin M - 1,36 g/l, class G - 14.5 g/l, class a - 2,4 g/l Protein fractions of blood: total protein - 89,3 g/l, globes the s - of 45.3 g/l, A/G ratio - 1,21, α-1-globulins of 6.1%, α-2-globulins - 8,5%, β-globulins and 10.3%, γ-globulin - 18,3%.

Diene conjugates in plasma lipids blood - 1.82 relative. units, malonic dialdehyde (MDA), erythrocyte - 49,mol/ml aritri. mass, malonic dialdehyde lipids (MDA)- 12,05 nmol/mg lipid, serum catalase - 28.5 µkat/l ceruloplasmin - 0,219 g/l

Psychological tests: test SAN 144 points (subcompensated state). Psychovegetative questionnaire Wayne - 47 points (vegetative dysfunction syndrome).

The results of the initial examination of the patient revealed subcompensated state of psycho-emotional sphere, dysproteinemia, higher level α-1 - γ-globulin, the collapse of the cellular and humoral immunity, the voltage in the system of lipid peroxidation and antioxidant system. According to the leukocyte blood - defective reaction peaceful activation.

The patient was prescribed a course of treatment by the proposed method. After treatment, the patient noted significant improvement in well-being, increased activity, mood, improving sleep, which is confirmed by psychological tests (test SAN 178 points, questionnaire Wayne - 26 points).

By the end of treatment was completely absent soreness in the study of the genital organs, marked RA is sativali effect - the vault became available, the appendages are not increased, is determined by the light tictacti in the field of appendages.

According to the General analysis of blood indicators of red blood remained virtually unchanged, decreased the number of leukocytes to 5.65×109/l and decreased erythrocyte sedimentation rate, up to 4 mm/h, increased monocytes by up to 8%.

According to the biochemical analysis of blood serum decreased total protein to 79,0 g/l and α-1 globulins (5,7%), normalized A/G ratio (1,32) and rose γ-globulins (21,3%). Decreased tension in the FLOOR system and AOD - diene couaty - 1,62 otose, of erythrocyte MDA - 32,59 nmol/ml aritri. mass, MDA lipid - 7,58 nmol/mg lipid, serum catalase - 25.6 µkat/l ceruloplasmin - 0,289 g/l

Positive dynamics of indicators of immunological indexes: decreased number of leukocytes to 6.2 thousand/µl lymphocytes to - 1876/µl. The level of T-lymphocytes remained almost unchanged (55% - 1038,0/ml, but increased immunoregulatory index (1,27) by enhancing T-helper cells (30% - 840,0/μl), and the content of T-suppressors (23% - 642,9/µl) has not changed. From humoral immunity at the end of treatment increased levels of immunoglobulin G (15.5 g/l) and decreased the level of class M (1.24 g/l), CRP - negative.

According to rectal thermometry two - phase menstrual cycle.

Thus, the treatment results in improvement of the psycho-emotion is a high status, analgesic, defibrination action, improvement of function of the ovaries, increased resistance, decreased activity of PAUL and AOD, immunostimulating effect.

Diagnosis after treatment: Infertility I.

The patient was discharged with significant improvement.

After treatment at the resort the patient had no complaints, and after 5 months of pregnancy.

Just examined and treated in the clinic of the center 58 women through 3-15 months after reconstructive operations regarding tubal-peritoneal infertility in age from 20 to 35 years, with a limitation of the inflammatory process in the small pelvis organs from 2 to 10 years in the two groups.

The first group of 33 women were treated by the proposed method (table 3).

The second group of 25 patients received treatment according to the prototype by bromine balneotherapy in the form of vaginal lavage and General baths, at the rate of 8 hydrotherapy.

At the end of treatment all patients reported improvement in General condition. Integral assessment of the psycho-emotional status of patients using test SAN revealed before treatment, 64% of women decompensated and subcompensated state. At the end of treatment subcompensated psycho-emotional state was observed only in 8% of women of the first group and in 6% of patients of the second group. Total score according to test SAN of truth is about increased in both groups (144,7± 9.8 to 180,2±8.7 points in the first group and the second group - to 150.1±7,3 to 175.8±8.1 points).

The state of the ANS, according to the questionnaire Wayne (average score of 31.5±2,7), most of the patients before treatment was characterized by the presence of vegetative dysfunction syndrome. After treatment in the first group, this score decreased significantly from 36.2±1,2 to 18.1±2.3 grade and half of the patients (48%), it decreased to normal values (less than 15 points), and in the second group with 33,3±1.9 to 20,1±1.2 points.

Before treatment, 64% of women complained of pain in the lower abdomen and lumbosacral region, which were intermittent in nature, 49% of patients reported algomenorrhea, 21% for heavy menstruation. During bimanual examination adhesions in the pelvis of varying severity and painful study of the genital organs was observed in most women (96%).

At the end of treatment pain in the lower abdomen and lumbosacral region disappeared in 90% of patients of the first group and in 80% of women of the second group. Reducing pain during menstruation was observed in 90% of patients of the first group and 67% in the second group.

According to a vaginal examination at the end of treatment reduced severity of adhesions observed in both groups, but more pronounced positive dynamics identified in the group of patients treated electrophoresis the gross dirt in combination with bromine balneotherapy. The disappearance of adhesions in this group registered in 37% of women in the second group at 17%. Bimanual examination at the end of treatment was painless 35% of women of the first group and 22% in the second.

Under the influence of the treatment improves blood flow to vascular pelvis. The tone of the small and medium arteries, and venous outflow are normalized in both groups. Reducing the source of elevated results were recorded in 80% of cases in the first group and in 77% of cases in the second. And improving blood 0.11±from 0.005 to 0.18±0,009 used (p<0.05) were obtained under the influence of bromine balneotherapy in combination with electrophoresis of mud (in the second group of 0.18±0,009 to 0.20±0,01 used).

In the course of the research revealed positive dynamics of adaptive reactions of blood (leukocyte formula) Garkavi LH in both groups. However, in the first group at the end of treatment was observed more pronounced increase in the level of resistance of the organism by increasing the number of reactions increased activation (table 3). And in the second group, the level of calm reactions activation by reducing the number of reactions with high activation.

The reduction in the number of defective reactions at the end of treatment was approximately equal in both groups (9 and 11.0%, respectively), which may indirectly indicate the and the normalization of the functioning of the endocrine system when exposed to applied medical complexes.

Table 3
Dynamics of adaptive responses (%).
ReactionThe placeholderThe proposed method
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatment
Training--66
Calm activation2137.56319
Increased activation7962,53175
All defective36253829

Proof of this is the normalization of rectal temperature during treatment. So, before treatment number of patients with biphasic rectal temperature in the first group was 13%, and the second is 9.1%, and after treatment increased in the first group to 33% (20%) cases, and the second to 12.5% (3.4%). While the number of women who at the end of treatment was determined by single-phase rectal temperature decreased in the first group, 5%, and the second remained on the same level.

At the end of treatment the improvement achieved in the dynamics is similar to the modified indicators of protein fractions of blood serum in both groups. However, normalization of the ratio of albumin and globulins and γ-globulin obtained in the group treated by the proposed method (table 3). The high content of α-1 globulin before treatment was approximately equal (73 and 77%)and after treatment in the first group level α-1 globulin decreased in half of women (50%), while the second group only 1/3 (33%) women.

Table 4
Dynamics of biochemical indices of blood serum
IndicatorsMedical group
The proposed methodThe placeholder
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatment
A/G<1,31,21±0,0121,33±0,029 p<0,021,10±0,0121,19±0,028
A/G≥1,341,52±0,0311.44MB±0,0581,43±0,0211,29±0,053 p<0,05
α-1-globulins, ≥5,2%6,18±0,315,96±0,216,16±0,135,95±0,12
γ-globulins, ≥20,7%21,4±0,2419,9#x000B1; 0,7522,4±0,4121,7±0,51
Diene conjugates ≥2,6 used3,36±0,243,45±0,352,45±0,212,68±0,39
MDA, erythrocyte. (norm - 39,5±0,92 nmol/ml aritri. mass)45,9±2,2841,2±2,6144,6±1,450,0±2,61
MDA, erythrocyte. ≥43,4 nmol/ml aritri. weight54,4±1,9238,9±2,75 p<0,0156,3±2,448,0±2,8 p<0,05
HMM lipids ≥8,65 nmol/mg of lipids13,4±0,8110,2±0,81 p<0,0512,3±0,8412,3±0,98
Catalase serum ≥23,0 µkat/l40,8±2,0435,2±1,9533,3±1,2334,6±1,84

Before treatment, more than half of the patients had increased rates of lipid peroxidation (LPO). Under the impact of the proposed treatment method decreases the tension in the FLOOR system due to a significant decrease of the initial high rate (table 4). Before treatment malonic dialdehyde was increased in 60% of women of the first group and in 56% of the second group. Under the influence of treatment, its level decreased in the first group in 75% of cases, and the second only 20%. Also reduced is camping under the influence of applied medical complexes voltage in the antioxidant defense system, but more pronounced under the influence of the proposed method. Reduction of the initial high level of diene conjugates in this group achieved in 70% of women in the second group - 33%), with 15% of them to normal values.

Positive dynamics of immune status in both groups, however, in the first group, this trend was more pronounced. At the end of the treatment initially elevated levels of leukocytes and lymphocytes as indicators of the severity of the inflammatory process is reduced in the first group in 70% of cases, while in the second 50% of cases. Activates cellular immunity, all women in both the first and second groups increases initially reduced the level of T-lymphocytes. But on average the performance over a significant increase in their level obtained in the first group, where T-lymphocytes increased from 53.1±1,31 to 58.8±1,7% (p<0,02), and in the second group from 52.9±1.16 to 56,9±1,26% (p<0,05). Increased levels of T-lymphocytes marked by enhancing T-helper cells in both groups. Therefore, increased and immunoregulatory index (IRI). In 60% of cases in both groups increased on Iran, until treatment was less than 1.0.

After treatment, the level of immunoglobulin a and G in both groups has not changed, and the original elevated levels of immunoglobulin M in the first group snails is from 1.77± 0,019 g/l to 1.49±0,067 g/l (p<0,001), the second with 1.66±0.04 g/l to 1.36±0.02 g/l (p<0,05).

Evaluation of treatment effectiveness in percent was conducted according to guidance the USSR Ministry of health, performance Criteria sanatorium treatment" (1984). Based on the analysis of the obtained data, the effectiveness of the treatment in the first group was higher than in the second group (table 5).

Table 5
The treatment efficiency (%).
The treatmentSignificant improvementImprovementA slight improvementWithout change
The placeholder-2872-
The proposed method12,175,812,1-

Long-term results of treatment (after 6-10 months) were obtained from 14 women who received treatment by the proposed method. They all felt good, lower abdominal pain didn't bother. Of the 3 women for whom treatment was observed algomenorrhea, only one began a slight pain during menstruation after 7 months. In 5 women has become pregnant, one in 4 months - a tubal pregnancy.

Thus, the application sets the UNC health-resort method, including electrophoresis silt mud, enriched hydrogen sulfide water through the day with bromine balneotherapy in the form of vaginal lavage and shared baths in the treatment of women after reconstructive operations regarding tubal-peritoneal infertility allows to achieve a pronounced resolving and analgesic effects increase nonspecific resistance of the organism, reducing the activity of the FLOOR, the normalization of psycho-emotional status and indices of cellular and humoral immunity, recovery of ovarian function and increase fertility.

Table 1
Physico-chemical characteristics of therapeutic mud
Field N. Tambukan Stavropol KraiAdler silt mud, enriched with sulphurous water in hydrogen sulfide concentration of 350 mg/l
Organoleptic characteristics: colour, odour, consistency, plasticityBlack, mos, homogeneous, plastic, oilyBlack, homogeneous, plastic, greasy
Humidity, %60,060,0
Volumetric weight %1,41,33
rn/td> of 7.2 to 7.76,7
Eh, ml-140-260-60
Shear, Dyne/cm22400-36002300
The content of sulphides in % of crude mud0,15-0,260,17
The content of organic matter in % on a dry dirt2,2-2,50,20
The debris particles greater than 0.25 mil, %To 1.00,20
M g/l8326,2
Formula mud mortarSo4 Cl 64 34 (Na+K) 54 Mg 43Cl 93 (Na+K) 75 Br 0,055 Y 0,010

A method for the treatment of tubal-peritoneal infertility after reconstructive surgery for women by bromine balneotherapy as public baths and vaginal irrigation, temperature 36°With, every other day, characterized in that after 2 days of adaptation to the days free from baths and irrigations, conduct electrophoresis silt mud, enriched with sulphurous water in hydrogen sulfide concentration of 350 mg/l, in the region hypogastric and lumbosacral region at the level of L4-S2 vertebrae at current strength of 0.05-0.1 MA cm220 min, at a rate of 8 balneotherapy and physiotherapy.



 

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EFFECT: accelerated menstrual and reproductive function recovery.

FIELD: organic chemistry, biology, pharmacy.

SUBSTANCE: invention relates to derivatives of thieno[2,3-d]pyrimidine of the general formula (I): or their pharmaceutically acceptable salts wherein R1 and R2 in common with nitrogen atom to which they are added form a ring comprising from 2 to 6 carbon atoms and optionally comprising one or more heteroatoms chosen from nitrogen (N), oxygen (O) and/or sulfur (S) atoms. Proposed compounds possess ability to activate both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and can be used in therapy in aims for regulating fertility. Also, invention describes a pharmaceutical composition based on compounds of the formula (I).

EFFECT: valuable biological and medicinal properties of compounds and pharmaceutical composition.

6 cl, 1 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with the method of applying compositions containing trans-clomiphen and cis-clomiphen in the ratio by weight being above or equal 71/29 for increasing the level of testosterone in blood serum in male mammalian. Application of practically pure trans-clomiphen according to the present innovation provides increased level of testosterone both at the decrease and at sufficient content of this hormone, in case of necessity or desirability of such an increase for a mammalian, at decreased number of side effects as a result of clomiphen-based therapy.

EFFECT: higher efficiency of therapy.

4 cl, 3 dwg, 2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves prescribing walking in terrain in combination with biologically active additive «Phytopan M» received as herbal tea. Walking is done in the terrain having slope angle from 0 to 6° during 1.5-3 h individually dosing loading power taking into account heart beat rate frequency increment value measured during 1 min.

EFFECT: enhanced effectiveness of treatment course; improved microcirculation and a lymph drainage of small pelvis organs.

1 dwg

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes glycine-substituted thieno[2,3-D]-pyrimidines of the formula (I): wherein X represents oxygen atom (O) or H,H; A represents sulfur atom (S), -NH, -N(R6), O or a bond; R1 represents (C1-C4)-alkyl, (C2-C4)-alkenyl, unsubstituted or substituted phenyl, thienyl, pyridyl; R2 represents hydrogen atom (H), (C1-C4)-alkyl, (C1-C4)-alkoxy-(C2-C4)-alkyl or hydroxy-(C2-C4)-alkyl; R3 and R4 are chosen independently from H, (C1-C4)-alkyl and hydroxy-(C1-C4)-alkyl; R5 represents H or (C1-C4)-alkyl, and R6 represents (C1-C4)-alkyl. Compound possess agonistic activity with respect to glycoprotein hormone, in particular, to compounds possessing agonist activity with respect to luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Also, invention describes pharmaceutical compositions containing such compounds and using these compounds in medicinal therapy, in particular, for fertilization control.

EFFECT: valuable biological and medicinal properties of compounds.

11 cl, 1 tbl, 27 ex

Spermicidal agent // 2315602

FIELD: medicine.

SUBSTANCE: invention relates to contraceptive agents. Invention reports the presence of spermicidal activity in sulfacyl-sodium (para-aminobenzene sulfacetamide-sodium known as sodium sulfacetamide also) and momentary death of sperms at concentration of sulfacyl-sodium from 20% and above. The combination of this activity with the known early antiprotozoan and antibacterial effect with respect to gonococci, chlamydiae, streptococci and staphylococci sulfacyl-sodium enhances its significance as vaginal contraceptive agent essentially and shows absence of such adverse effects as irritation, allergic responses, burning and intense itching.

EFFECT: valuable properties of agent.

1 tbl

FIELD: medicine, gynecology.

SUBSTANCE: for pregnant woman at localization of ovum in cervix or cervico-isthmus uterine department it is necessary to inject methotrexate by flow technique at 50 mg/sq. m body surface intravenously at gestation terms being 7 wk, not more. Then 7 d later one should carry out vacuum excochleation of fetal ovum followed by tamponade of cervical canal with a sterile bandage impregnated with aminocaproic acid. It is necessary to fulfill vaginal tamponade with a cotton-gauze tampon for the period of 2 d. The innovation in question decreases the risk of hemorrhage due to implementing the operation in optimal terms after injecting methotrexate that in combination with increased efficiency of post-surgical hemostasis provides high level in maintaining reproductive function in this category of patients.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine, gynecology, endocrinology.

SUBSTANCE: it is necessary to fulfill combined impact upon hypothalamo-hypophysial-ovarian system due to simultaneous introduction of vascular and nootropic metabolics (for example, kavinton and glycine), multivitamins including the group out of seven vitamins "B" (folic and pantothenic acids among them), and hepatoprotectors (chophytol). They should be introduced for the period of 2 mo. The innovation provides complex impact upon all the links in the system of hypothalamo-hypophysial-ovarian system, normalization of metabolism and, thus, normalization of menstrual cycle.

EFFECT: higher efficiency of correction.

4 cl, 3 ex, 1 tbl

FIELD: treatment of male and female impotency.

SUBSTANCE: invention proposes a pharmaceutical composition used in treatment of male and female sexual dysfunctions and comprising extracts from Tribulus terrestris, Epimedium koreanum and Cinnamon cassia taken in the definite weight ratio and optionally arginine or physiologically equivalent ester, its salt or precursor and a suitable carrier or excipient. Also, invention relates to using extracts from Tribulus terrestris, Epimedium koreanum and Cinnamon cassia taken in the definite weight ratio and optionally arginine or its physiologically equivalent esters, salts or precursors for preparing a medicinal agent used in treatment of male and female sexual dysfunctions. Also, invention relates to a pharmaceutical composition used in treatment of male and female sexual dysfunctions that comprises the effective amount of dioscine prepared from Tribulus terrestris, icarine prepared from Epidemium koreanum and cinnamic aldehyde prepared from Cinnamon cassia, and a suitable carrier or medium for a drug. Also, invention relates to using dioscine prepared from Tribulus terrestris, icarine prepared from Epidemium koreanum and cinnamic aldehyde prepared from Cinnamon cassis for preparing a medicinal agent used in treatment of male and female sexual dysfunctions. Above describes compositions are effective in treatment of male and female sexual dysfunctions. The proposed invention is used in treatment of male and female sexual dysfunctions.

EFFECT: enhanced effectiveness and valuable medicinal properties of drug.

8 cl, 5 ex

FIELD: pharmaceutical industry, pharmacy, biology.

SUBSTANCE: invention relates to a pharmaceutical composition used in treatment of male and female impotency. The composition comprises extracts from Tribulus terrestris, Turnera diffusa and Cinnamon cassia taken in the definite weight ratio, and extract from Ginkgo biloba wherein Ginkgo biloba is represented by fraction of apigenine dimeric flavonoids containing in the amount that provides daily using of indicated fraction and, optionally, arginine or its physiologically equivalent ester, salt or precursor in mixture with a suitable carrier or excipient. Also, invention relates to extracts from Tribulus terrestris, Turnera diffusa and Cinnamon cassis taken in the definite weight ratio in combination with extract from Ginkgo biloba and, optionally, with arginine or its physiologically equivalent eaters, salts or precursors for preparing a medicinal agent used in treatment of male and female sexual dysfunctions. Above describes pharmaceutical composition is effective in treatment of male and female impotency. Proposed invention is used in treatment of male and female impotency.

EFFECT: enhanced effectiveness and valuable properties of medicinal formulations.

7 cl, 5 ex

FIELD: medicine, sexology, biochemistry, pharmacy.

SUBSTANCE: invention discloses a rapidly acting pharmaceutical composition showing high bioavailability containing active compound in sexual dysfunction and not presenting chew elastic. Active compound is chosen from derivatives of compounds of the formula (I) or (II) given in the invention description, or compound chosen from inhibitors of phosphodiesterase type 5, such as sildenafil, vardenafil, tadalafil, or compound chosen from dopaminergic agonists, such as apomorphine, or compound chosen from noradrenergic α-antagonists, or compound chosen from activators of cyclic AMP with a addition of cacao powder as not component of chocolate for adequate taste masking, and one or more lipid components.

EFFECT: valuable biological properties of pharmaceutical compositions.

19 cl, 4 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I) and their pharmaceutically acceptable salts. Proposed compounds possess properties of agonists of receptors activated by peroxisome proliferators (PPAR agonists) and can be used in treatment of such diseases as diabetes mellitus, hypertension, atherosclerotic diseases and others. In the general formula (I) R1 means lower alkyl, monocyclic (C3-C6)-cycloalkyl; R2 means hydrogen atom, halogen atom, lower alkyl, lower alkoxy-group wherein at least one of three radicals R3, R4, R5 or R6 is not hydrogen atom; or R3 and R4 are bound together to form a ring with carbon atoms to which they are bound, and R3 and R4 mean in common -CH=CH-S-, -S-CH=CH-, -CH=CH-CH=CH-, and R5 and R6 are given above; R7 means lower alkyl, lower alkenyl; R8 means hydrogen atom or lower alkyl; n = 1, 2 or 3. Also, invention relates to a pharmaceutical composition based on the invention compounds and to using compounds of the invention in preparing medicinal agents used in treatment and/or prophylaxis of diseases mediated by agonists PPARα and/or PPARγ.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

20 cl, 1 tbl, 13 sch, 71 ex

FIELD: medicine, andrology, obstetrics, gynecology.

SUBSTANCE: the present innovation deals with treating sterility, at intrauterine insemination and extracorporal fertilization. For implementing the method suggested it is necessary to dilute 0.4 ml ejaculate in 0.4 ml physiological solution (0.9%-NaCl solution), then one should add about 0.3-0.6 ml perfluoran to keep at mixing and shaking for 3 min. The innovation enables to increase qualitative parameters of sperm: increase the number of mobile spermatozoa in ejaculate, increase respiratory ability of spermatozoa, increase Farris' calculation value that increases the probability for fertilization.

EFFECT: higher efficiency of therapy.

3 ex, 3 tbl

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to diazacycloalkanes of the general formula (I): wherein G1 represents condensed polycyclic group. Compounds are selective and strong acting agonists of oxytocin and can useful in treatment of erectile dysfunction. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and their using in manufacturing the pharmaceutical composition.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

31 cl, 136 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to diazacycloalkanes of the general formula (I): wherein G1 represents condensed polycyclic group. Compounds are selective and strong acting agonists of oxytocin and can useful in treatment of erectile dysfunction. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and their using in manufacturing the pharmaceutical composition.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

31 cl, 136 ex

FIELD: medicine.

SUBSTANCE: method involves placing three circular electrodes of different area so that the smaller two are placed on orbital and upper eyelids region skin when eyes are closed. They are connected with split wire to an electrode of greater area that is placed in cervico-occipital region of patient head. Injured regions electrophoresis is carried out with 1.5% Neuromidine solution according to ophthalmo-occipital method placing patient in dorsal position. Current is supplied to light pricking sensation under the electrodes. Given current intensity is controlled over the treatment time. Procedure duration is 15-20 min and treatment course is 15 daily sessions long.

EFFECT: enhanced effectiveness in treating defective neuromuscular eyeball synapses and nuclear structures of oculomotor nerves.

2 cl

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