Device for treating skin mucous membrane carcinoma cases

FIELD: medical engineering.

SUBSTANCE: device has tripod bearing X-ray therapy tube having radiation source and radiographic cone. The cone has cylindrical part having flange at one end provided with fastening members to be fixable in the X-ray tube and conic part on the other end. Protective lead aperture is available on the same side with the flange. Its inlet orifice diameter is less than the outlet orifice diameter for producing divergent conic X-ray beam. A through opening is available in the cylindrical portion of the X-ray cone arranged at an angle of 45-50° to its axis with laser radiator being placeable into it.

EFFECT: enhanced effectiveness in carrying out one-stage radiation therapy and laser radiation therapy of malignant diseases.

2 dwg

 

The invention relates to medicine, namely to Oncology, and may find application in korotkoperiodnoi radiation and low-intensity laser therapy of superficial malignant tumors of the skin and mucous membranes for prevention and treatment of injuries resulting from radiation therapy, mainly malignant tumors of the maxillofacial region.

Radiation reaction is an inevitable companion of radiation therapy of tumors and are accompanied by General and local reactions to healthy skin and organs. External beam radiation is inevitably linked with local radiation reactions of the skin and mucous membranes. Among the skin reactions are its redness (erythema) and dry radiometeric. On the mucous membrane of the local radiation reaction manifested as erythema, alopecia (islet) and diffuse drain epithelitis (radioactice). All three stages usually occur when conducting remote gamma-therapy cancer of the mucous membrane of various departments of the mouth.

With the modern technology of radiation these reactions usually do not reach severe. However, the physician should be familiar with their signs and shall take all measures for their prevention and treatment.

So you know the device (see patent RU No. 2189221, publ. 2002.09.20), in which the more radical the ay reach reduce damage to healthy tissue, surrounding the pathologic lesion, treatment is not outside, but inside. This path is realized, in particular, by implantation directly into the pathologic lesion capsules with an active material.

The disadvantage of this device is the necessity of its implantation in the pathologic lesion through surgery and related complications continue treatment.

In addition, surgical intervention is undesirable in the maxillofacial region.

The main type rentgenoterapevticheskie devices used in radiation therapy, is the close-focus. Such devices are intended for irradiation with short distances pathological lesions, mainly tumors located on the body surface or mucous membrane.

The closest in technical essence and the achieved effect and is taken as a prototype is a device for the treatment of cancer of the skin and mucous membranes (see Lindenblatt L.D. and other Medical radiology (fundamentals of radiology and radiation therapy). The textbook. lit. for stud. the honey. higher education institutions. Technological support for radiation therapy. M.: Medicine, 1993, S. 523-527), containing close-focus rentgenoterapevticheskie machine ROOM-21 equipped with a tripod mounted thereon provided with a radiation source, rentgenoterapii the th tube with a set of tubes of various shapes and sizes, with the ability to limit the size of the irradiated field and the permanence of the distance from the source to the surface of the body. Irradiation is carried out from a distance of 7.5-15 see This device provides a simple and accurate guidance of the working beam irradiated on the object. In all cases, the use of radiation therapy medical complex is aimed at the destruction of tumor, preserving surrounding healthy tissues and strengthening of protective forces of an organism.

However, the known device has the disadvantage inherent in all rentgenoterapevticheskie devices for radiation exposure, namely, that as a result of intensive courses of irradiation arise radiation tissue damage.

The objective of the invention is the prevention and reduction in the incidence of local radiation injuries and the reduction of treatment time, resulting from radiation therapy.

The technical result is the creation of optimum device that allows simultaneous radiation and laser therapy of malignant tumors.

The problem is solved in that in the known device for the treatment of cancer of the skin and mucous membranes, containing the tripod attached to it is equipped with a radiation source rentgenoterapevticheskie tube with a set of tubes of various shapes and sizes, housing roentgenotherapy the second tube is additionally equipped with a cylindrical tube, supplied with one end flange, equipped with locking elements, with the possibility of fixing it in rentgenoterapevticheskie tube, and the other end of the cylindrical tube provided with a conical part, with the inner hole of the tube-side flange has a protective lead aperture, the input aperture of a smaller diameter in comparison with the outlet, in addition to the cylindrical part of the tube at an angle of 45-50° its axis is made a through hole, with the ability to accommodate laser emitter.

Studies on the sources of patent and scientific and medical information showed that the present invention is unknown and should not be explicitly studied material, i.e., meets the criteria of "novelty" and "inventive step".

The invention can find application in the treatment of cancer patients, in particular in radiation therapy, with the possibility of prevention of the complications of radiation through the use of this device, manufactured at the enterprises of this kind, both domestic and foreign industry, therefore, "industrially applicable".

Additional supply of housing rentgenoterapevticheskie head cylindrical tube provided at one end with a flange, equipped with fixing the elements, with the possibility of fixing it in rentgenoterapevticheskie tube, and the other end is a cylindrical tube provided with a conical part, the total length of which allows to maintain the constant distance from the radiation source to the surface of the body, thus the cone reduces to a specified dimension of the outer diameter of the tube.

The interior hole of the tube-side flange protective lead aperture, the input aperture of a smaller diameter in comparison with the outlet, allows you to generate a diverging conical beam of x-rays.

Execution in the cylindrical part of the tube at an angle of 45-50° its axis through holes with the ability to accommodate laser emitter allows simultaneous radiation and laser therapy of malignant tumors, while it is found experimentally that specified in the range of 45 to 50° the angle of the holes and the protective material of the laser emitter prevent lateral leakage radiation.

Thus, the set of essential features allows you to achieve a technical result, namely, creating an optimal device allowing simultaneous radiation and laser therapy of malignant tumors.

The present invention explains the I drawings, where

- Fig 1 is a perspective view from above of the device shown in a perspective view;

- Fig 2 is a General side view.

Device for the treatment of cancer of the skin and mucous membranes contains a tripod mounted thereon provided with a radiation source rentgenoterapevticheskie tube, which is equipped with the ability to limit the size of the irradiated field tubes of various sizes (not shown), while rentgenoterapevticheskie tube equipped with a tube 1 made in the form of a cylinder 2, provided at one end with a flange 3, are equipped with locking elements 4, with the possibility of fixing it in rentgenoterapevticheskie tube, and the other end of the cylinder 2 has a conical part 5. The internal bore of the cylinder 2 from the side of the flange 3 has a protective lead aperture 6 with the inlet 7 with the possibility of formation of a divergent conical beam of x-rays on the exit hole 8. In addition, on the side of the cylinder 2 at an angle of 45-50° its axis is a through hole with the ability to accommodate the sleeve 9 with a through hole 10, is equipped with a laser emitter (not shown).

Set the length of the side walls of the tube 1 and the diameter of the outlet 8 depend on the shape and height of the tumor and, in addition, the length of the tube provides a constant distance of the long-term equilibrium radiation to the surface of the body, and the diameter of the outlet 8 limits the size of the irradiated field.

It was established experimentally that the specified diameter of the through hole 10 of the sleeve 9, is installed with a tilt angle equal to 45-50° to the axis of the tube 1, allows you to create a field irradiation with low-intensity laser blocking on the calculated value of field x-ray emitter, with no side leakage x-ray radiation through the opening 10, which together protect healthy skin from radiation complications.

Device for the treatment of cancer of the skin and mucous membranes are used as follows.

Depending on the shape and height of the patient's tumor pick up an extra tube 1 to rentgenoterapevticheskie tube. In hole 10 is injected laser emitter and initially irradiated tumor laser beam. After 30-50 seconds and include produce irradiation her rentgenoterapevticheskie tube during the time required to obtain a therapeutic dose, for example of 3.7 Gy. After disabling x-ray irradiation through 30-50 sec disable laser irradiation.

The advantage of the proposed simultaneous x - ray and lasermouse compared to x-ray irradiation of the prototype is to prevent and reduce the frequency of local radiation injuries and reduction of terms of treatment result in damage to the Oia laser radiation.

Device for the treatment of cancer of the skin and mucous membranes, containing tripod mounted thereon provided with a radiation source rentgenoterapevticheskie tube, equipped with a tube, wherein the tube is made in the form of a cylindrical part provided at one end with a flange, equipped with locking elements, with the possibility of fixing it in rentgenoterapevticheskie tube, and the other end is tapered part, with the side flange hole of the tube has a protective lead aperture, the input aperture of smaller diameter than the hole, with the possibility of forming a diverging conical beam of x-rays, and in the cylindrical part of the tube at an angle of 45-50° its axis is made a through hole, with the ability to accommodate laser emitter.



 

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1 ex

FIELD: medicine.

SUBSTANCE: method involves intravenously introducing chlorine row photosensitizer in pharmaceutical water-soluble dosage form at a dose of 0.7-1.05 mg/kg during 10 min. Fluorescent spectral diagnostic analysis of chlorine row photosensitizer accumulation is carried out in intraocular neoplasm in 1 h after having finished introduction. Neoplasm fluorescence being observed on the background of surrounding tissue, chlorine row photosensitizer in pharmaceutical liposome dosage form is introduced as intravenous bolus dose of 0.3-0.45 mg/kg. 10-15 min later after having finished the injection, laser radiation is applied tumor periphery is irradiated all over the whole tumor perimeter in transpupillary mode in laser radiation fields using wavelength of 670 nm with power density of 60-80 J/cm2 with neighboring fields overlapping over 5% of area. Then the whole neoplasm surface is irradiated in transpupillary mode in laser radiation fields using wavelength of 662 nm with power density of 100-120 J/cm2 with neighboring fields overlapping over 5% of area. Irradiation is carried out in circle moving from periphery towards the center. When calculating superficial ophthalmoapplicator dose in brachytherapy, initial tumor thickness is to be reduced by 4 mm.

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FIELD: medicine.

SUBSTANCE: method involves carrying out brachytherapy. Chlorine row photosensitizer is introduced in pharmaceutical water-soluble dosage form at a dose of 0.7-1.05 mg/kg during 10 min. Fluorescent spectral diagnostic analysis of chlorine row photosensitizer accumulation is carried out in intraocular neoplasm in 1 h after having finished introduction. Neoplasm fluorescence being observed on the background of surrounding tissue, chlorine row photosensitizer in pharmaceutical liposome dosage form is introduced as intravenous bolus dose of 0.3-0.45 mg/kg. 10-15 min later after having finished the injection, laser radiation is applied tumor periphery is irradiated all over the whole tumor perimeter in transpupillary mode in laser radiation fields using wavelength of 670 nm with power density of 60-80 J/cm2 with neighboring fields overlapping over 5% of area. Then the whole neoplasm surface is irradiated in transpupillary mode in laser radiation fields using wavelength of 662 nm with power density of 100-120 J/cm2 with neighboring fields overlapping over 5% of area. Irradiation is carried out in circle moving from periphery towards the center. When calculating superficial ophthalmoapplicator dose in brachytherapy, initial tumor thickness is to be reduced by 4 mm.

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SUBSTANCE: method involves carrying out the preliminary catheterization of larynx artery and the following intra-arterial chemotherapy by administration of cisplatin as 6 h infusion of 80-100 ml of 0.0025% solution from 1-st to 4-th day of treatment in the total dose 100 mg/m2, 5-fluorouracil as 3 h infusion of 20 ml of 5% solution from 5-th to 7-th day of treatment in the total dose 3 g. After termination of chemotherapy in 2-3 weeks after arresting adverse reactions in tumor regression above 50% the larynx resection is carried out and in regression less 50% - laryngoectomy. In 3-4 weeks after surgery operation the distance radiation therapy is carried out in a single irradiation dose 2.0 Gr in irradiation regimen 5 times per a week and in the total dose 40-46 Gr in laryngoectomy and 60-66 Gr in organ-retaining surgery operation depending on the stage of the primary process. Method provides the functional rehabilitation of patients and decreasing expression and amount of total complications of complex therapy based on step-by-step carrying out the treatment. Invention can be used in treatment of patients with locally spread squamous larynx cancer.

EFFECT: improved method of treatment.

1 ex

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