Method for treating periodontitis cases

FIELD: medicine.

SUBSTANCE: method involves drying injured zone after having removed dental deposit and additional treating cement surface in inflammation zone with citric acid solution of 0.1 mMole/l concentration during 5 min, and then with 0.06% Chlorohexidine solution and Nikiforov mixture. Sulfacrylate is placed into periodontium pocket as glue periodontial bandage and the lesion focus is treated with ultrasound of 26.5 kHz during 3 s.

EFFECT: accelerated treatment course; activated reparative processes in periodontium; improved mechanical strength; accelerated polymerization in glue bandage.

2 tbl

 

The present invention relates to medicine, namely to the dentist, and can be used in the treatment of periodontal diseases.

There is a method of treating periodontal disease, which after removal of dental plaque, the elimination of acute inflammation, curettage on the gum after pre-drying, put periodontal dressing MK-14, containing 0.2% chlorhexidine digluconate. Prepare adhesive bandage immediately before use by combining content 2 syringe-tubes in plastic mixer. Content put on the gum layer to a thickness of 3-5 mm 2-3 minutes comes polymerization of the composition (1). Efficacy of treatment was evaluated by the change of clinical symptoms, using samples Schiller-Pisarev, Kecke, Parma, by determining the index Russel, the time of formation of vacuum haematomas on Kulagina, and radiography. Re-examination held on 8-10 day after 6 months.

Closest to the present invention is a method of treating periodontal disease using adhesive compositions SC-1, which consists of a liquid base and filler. Adhesive is a mixture of monomers α-cyanacrylate acid. The composition of the filler is powdered dioxidine and orotic acid. The entity known treatment parodont is and is after careful removal of dental plaque on the gums after pre-drying impose a periodontal dressing. Before use, both parts of the bandage connect from the calculation 10-15 drops of adhesive on a portion of the filler. After thorough mixing with a spatula bandage is applied on the dried surface of the alveolar and marginal gingiva thickness of 3-5 mm 2-3 minutes comes polymerization of the composition. The bandage remains in the mouth from a few hours to 3-5 days (2). For the assessment of periodontal status, in addition to clinical data and x-ray studies, applied mathematical indices (indexes): PI and bone index Fuchs.

However, the known methods of treatment have significant disadvantages, namely:

1. The impact of exercise on alveolar and marginal gingiva, i.e. there is no local bactericidal effect on inflammation.

2. Reparative processes in the periodontium proceed much slower.

3. Do not provide sufficient mechanical strength, because the polymerization process of periodontal dressings slowed down and periodontal adhesive bandages are fragile.

4. A longer treatment time (10-15 days), but it is also possible relapses of the disease.

5. Unpleasant bitter taste periodontal dressings you who indicates in patients negative attitude to treatment.

6. The possible error in the preparation of periodontal dressings, because it is difficult to measure the individual components of the drug, which affects the adhesive properties of periodontal dressings.

7. Has the disadvantage of making adhesive bandages, because at the time the application is the adhesion of the adhesive to the hands of the doctor and to work.

Based on the existing level of technology in the treatment of periodontitis and disadvantages of the known methods of treatment, the task was: to improve efficiency and to reduce treatment time by providing local bactericidal effect on inflammation, activation of reparative processes in the periodontium, improve the mechanical strength and accelerate polymerization of the adhesive bandage.

The set task is solved as follows:

A method of treating periodontal disease is carried out by careful removal of dental plaque, curettage, drying the affected area with the subsequent imposition of periodontal adhesive bandages. New in the solution of the problem is that further treated surface of the cement teeth in the area of inflammation citric acid solution with the concentration of 0.1 mol/l for 5 minutes, and then 0,06% chlorhexidine solution and the mixture Nikiforova (alcohol and ether in the ratio 1:1). Then put glue run is, for example, Sulfacrylate in the periodontal pocket with subsequent effects on inflammation ultrasound frequency of 26.5 kHz within 3 seconds.

Explain any significant distinguishing features of the proposed method of treatment:

Additional surface treatment cements teeth in the area of inflammation citric acid solution with the concentration of 0.1 mol/l for 5 minutes due to the fact that the main substance of tooth cement deposited ions of calcium and phosphorus, can replace hydrogen ions. The effect of citric acid leaches salt from the basic substance of peripheral parts of the cement, creating the inside of about 15 to 32 μm, subsequently filled with glue Sulfacrylate that provides the micromechanical retention of the tooth root. In addition, citric acid has a bactericidal effect.

Treatment of inflammation of 0.06% chlorhexidine provides additional antiseptic treatment of periodontal pockets.

Treatment of inflammation of the mixture Nikiforova (alcohol and ether in the ratio 1:1) necessary to flush 0.06% chlorhexidine solution of formed the main substance of the peripheral parts of the cement of the tooth microdistrict, and drying the treated surfaces for better adhesion of the adhesive bandage.

Overlay adhesive bandages, with ISOE what Itanium, for example, drug Sulfacrylate in periodontal pocket provides local bactericidal effects on inflammation and the best mechanical strength of periodontal dressings.

Subsequent effects on inflammation ultrasound frequency of 26.5 kHz within 3 seconds, it accelerates polymerization of the adhesive periodontal dressings. The curing time of the adhesive periodontal dressings without exposure to ultrasound is 10-120 seconds depending on the thickness of the dressing. While under the influence of ultrasound polymerization begins immediately.

To determine the effectiveness of the proposed method of treatment of periodontitis experimental studies. The experiment was conducted on 65 outbred white rats weighing 150-170 g Periodontitis was modeled by imposing silk ligatures in the gingival sulcus for 7 days. All animals defined periodontitis. The first group (35 rats) and control without treatment. In the second group (30 rats) immediately after removal of the ligatures were washed gingival pockets 0,06% chlorhexidine solution, dried, and treated with a mixture Nikiforova, made in the gingival pockets periodontal adhesive bandage Sulfacrylate and evenly distributed using ultrasonic handpiece (frequency of 26.5 kHz) to accelerate polymerization of the adhesive composition. PEFC is the treatment of gingival pockets 0,06% chlorhexidine conducted additional processing citric acid solution 0,1 mol/l (pH 1), then again washed gingival pockets chlorhexidine. Material for research (a fragment of a lower jaw with teeth and gum section between them) were taken immediately after removal of the ligatures, and then after 3, 7, 14 and 21 days. Histological sections were stained pikrofusin by van gieson and using ocular grid was determined volume fraction leukocyte infiltration, sanguineous vessels, edema fluid, the newly formed collagen and foci of destruction in periodontal tissues. Data of the pilot study are described below.

9,9±0,8
Table 1
Structural indicators of periodontal tissues in experimental

the periodontal disease in the control group of animals.
Rate (percent V %)Time after removal of the ligatures (day)
0371421
GUMS
Leukocyte

infiltration
57,3± and 4.946,1±0,7*33,1±1,3*26±1*19,5±1,9*
Full-blooded

vessels
6,3±0,87,4±0,67,6±0,97,3±0,6
Immature

collagen
24,7±0,842,9±1,2*50,3±1,6*57,4±1,2*48,8±1,2*
Normal

cloth
11,1±1,43,6±1,3*8,9±1,3*8,3±1,824,2±1,2*
The PERIODONTIUM
Leukocyte

infiltration
43,9±7,235±0.316,4±0,4*14,2±0,59,8±0,3*
Swelling12,8±1,38,9±1,610,2±2,211,3±3,110,7±1,2
Full-blooded

vessels
6,9±213,4±313,6±4,414,2±1,38,6±2,3
Immature

collagen
12,5±2,438,6±4,3*50,6±4,3*56,2±2,345,4+2,2*
Normal

cloth
24+5,14,8±1,6*9,9+2,84,6±1,925,5+1,7*
BONE
Leukocyte

infiltration
16±4 43,6±3,2*28,3±3,1*12,6±2,8*8,9±2,2
Swelling11,1±2,212,5±1,512,5±2,214,7±2,17,8±0,9*
Full-blooded

vessels
0,1+0,10,3±0,13,4±0,7*3,4±1,17,9±1,3
Bone

fragments
0,6±0,35,5±2,22,4±1,13,1±1,12,5±0,3
Immature

collagen
6±1,47,2±1,516,6±2,5*35,5±4,4*15,6±2,4*
Normal

cloth
60±4,231,2±4,7*36,8±4,428,4±4,359,5±3,2*
Note: * - significant difference from the previous period
(P<0,05).

Table 2.
Structural indicators of periodontal tissues in experimental

periodontal diseases in animals treated according to the proposed technology using

antibacterial anti-inflammatory composition "Surface is at"

combination with citric acid.
Indicator (the proportion of V in %).Time after removal of the ligatures (day).
0371421
Gums
Leukocyte57,3± and 4.912,6±0,69,3±0,56,6±0,51,6±0,4
infiltration*/**/****/**/****/**/****/**/***
Full6,3±0,810,9±0,814,2±0,47,5±0,65±0,4
vessels*/***/**/****/**/****/**/***
Immature24,7±0,853,1±1,470±0,654,2±114,5±0,8
collagen*/***/**/****/****/**/***
Normal11,1±1,423,3±1,36,4±0,831,5±1,778,7±0,3
cloth*/***/*** */**/****/**/***
The periodontium
Leukocyte43,9±7,210,9±0,44,4±0,33,4±0,20,6±0,2
infiltration*/**/****/**/****/**/****/**/***
Swelling12,8±1,313,9±0,47,1±0,33,3±0,42,5±0,3
**/****/****/**/*****/***
Full6,9±216±0,38,7±0,43,5±0,41±0,3
vessels**/****/**/****/**/***
Immature12,5±2,437,3±0,449,7±0,465,3±0,47,3±0,4
collagen*/****/****/**/****/**/***
Normal24±5,121,8±0,729,9±0,924,4±188,5±0,7
cloth***/**/****/**/****/**/***
Bone
Leukocyte16±48,3±0,44,3±0,31,5±0,30,8±0,3
infiltration**/****/**/****/**/*****/***
Swelling11,1±2,211±0,58,9±0,54±0,41,6±0,3
****/****/**/****/**/***
Full0,1±0,110,2±0,37,5±0,43,2±0,31,1±0,3
vessels*/**/****/**/****/****/**/***
Bone0,6±0,31±0,10,4±0,20±00±0
fragments****/*****/*****
Immature6±1,426±0,521±0,726,3±0,710±0,9
collagen*/**/****/****/****/***
Normal60±4,243,1±0,757,6±1,364,8±186,4±1
cloth*/**/****/**/****/**/****/**/***
Note: * - significant difference from the previous period
(P<0.05)and ** - significant difference from untreated animals
(P<0.05)and *** - significant difference from animals treated without treatment with citric acid (P<0,05).

Thus, when using the adhesive composition Sulfacrylate with pre-treatment with citric acid, significantly fewer symptoms of inflammation (leukocyte infiltration, edema, plethora of vessels). Much more and faster collagenases and 21 days most fully restores all periodontal tissues. The presented data prove conclusively that the use of adhesive compositions Sulfacrylate with pre-treatment of inflammation of the proposed technology for the treatment of periodontitis effectively and quickly relieves inflammation in the periodontium, preventing destr the functions of tissues, it also activates repair processes that allows to recommend this method of treatment for use in the clinic.

Conducted patent research subclass AS 17/00, 17/20 and AC 9/34 and analysis of scientific and medical information that reflects the existing level of treatment of periodontitis has not revealed technology that is identical to the one proposed. Thus, the proposed method of treatment is new.

The relationship and interaction of the essential techniques of the proposed method achieves a new medical technology results in solving the task, namely, to increase efficiency and to reduce treatment time by providing local bactericidal effect on inflammation, activation of reparative processes in the periodontium, increasing the mechanical strength and accelerate polymerization of the adhesive bandage. Thus, the proposed solution involves an inventive step.

The proposed method for the treatment of periodontitis is industrially applicable, as it can be played repeatedly without requiring exceptional resources to implement.

The essence of the proposed "method of treatment of periodontitis" is as follows:

After careful elimination of local irritating factors (calculus, poor seals and Sunny the prosthesis), curettage, antiseptic treatment of periodontal pockets 0,06% chlorhexidine and drying, the surface of the cement treated teeth citric acid concentration of 0.1 mol/l pH 1 in 3-5 minutes. Then again spend antiseptic treatment of 0.06% chlorhexidine. Then carefully dried processed surface first with a cotton swab, and then treated with a mixture Nikiforova (alcohol and ether in the ratio 1:1). Then proceed directly to the introduction of the adhesive composition Sulfacrylate in the periodontal pocket using a narrow Board for otodviganija wall of the periodontal pocket. After placing periodontal dressings effect of ultrasound frequency of 26.5 kHz within 3 seconds, moving the tool from the tooth top to the neck of the tooth. The patient is given advice on oral hygiene. The treatment period of 5 days.

The essence of the proposed method is illustrated by a clinical example:

Patient, 56 years old, complained of bleeding gums, increased deposition of Tartar, bad breath, change the appearance of the gums.

History: considers himself ill since 1998, when I first noticed the bleeding. The periodontist has not previously been addressed. Practiced self-treatment: conducted oral baths with a solution of chamomile and oak bark that is was azalas ineffective. Suffering from hypertension.

Objective: interdental gingival papillae and the gum of the lower jaw hypermonogenic with cyanotic tint, swollen, bleeding upon probing. In the field 31, 32, 33, 34, 35, 41, 42, 43, 44, 45, 46 teeth are noted above - and subgingival dental plaque in abundant quantity. Hygienic index on the Fedorov-volodkina-2,9 (bad). Sample Schiller-Pisarev positive in the field 31, 32, 33, 34, 35, 41, 42, 43, 44, 45, 46 teeth. Test Kulagina 20-25 seconds. The index bleeding on Ketzchke 4 points - 2 degree of bleeding observed during the meal. The recession of the gingival margin by 1 mm area 31, 41 teeth. In the area above the teeth, periodontal pocket depth of 4 mm

On the orthopantomogram: bone resorption millionary partitions up to 1/3 the length of the tooth root in the field 31, 32, 33, 34, 35, 41, 42, 43, 44, 45, 46, the disappearance of the cortical plate all over.

Diagnosis: Chronic generalized periodontitis mild severity.

Treatment: teaching oral hygiene and controlled cleaning of the teeth. Under application anesthesia 10% lidocaine solution produced by the removal of dental plaque, replaced seals 34 tooth, the treatment of cervical cavities 32 and 33 teeth, removal of substandard bridges. Held closed curettage, medical treatment of periodontal pockets 0,06% solution is orexigen. Next process cement teeth citric acid concentration of 0.1 mol/l for 5 minutes. Then again washed periodontal pockets 0,06% chlorhexidine. After that dries periodontal pockets and process them with a mixture Nikiforova (alcohol and ether in the ratio 1:1). Then in periodontal pockets made periodontal adhesive bandage Sulfacrylate, then put a pinch of ultrasound, the frequency of 26.5 kHz within 3 seconds.

On the 3rd day of treatment significantly reduced bleeding gums, normalized appearance, gone bad breath. Hygienic index on the Fedorov-volodkina - 2,0 (satisfactory). Sample Schiller Pisareva positive 32, 33, 34, 43. Test Kulagina - 40 seconds. The index bleeding on Ketzchke - 2 points - 1 degree of bleeding is observed rarely. On the 5th day of the inflammatory process is stopped, the patient noted complete disappearance of bleeding gums. Sample Schiller-Pisarev negative in the teeth area of inflammation, hygiene index on the Fedorov-volodkina - 1,5 (good)test Kulagina 60 seconds. Bleeding gums when intubation is not observed. At 21 days of observation bleeding gums is completely absent, the test Kulagina - 60 seconds. Periodontal pockets in the area 31, 32, 33, 34, 35, 41, 42, 43, 44, 45, 46 the teeth are missing, hygienic Indus is with Fedorov-Volodkina - good.

Thus, the Method of treatment of periodontitis in comparison with other known treatment technologies improves the efficiency of treatment in a shorter time (the absence of inflammatory signs already at 5 days after treatment) due to local bactericidal effect on inflammation, activation of reparative processes in the periodontium, increasing the mechanical strength and accelerate polymerization of the adhesive bandage.

Sources of information:

1. Mscorlib, Gstudy, Ayekenova //Dentistry. - 1988. No. 2. - P.21-22.

2. Mccormally, Youranime, Ayekenova //Dentistry. - 1986. No. 5. - P.65-66.

The method of treatment of periodontitis, including the removal of dental plaque, drying the affected area with the subsequent imposition of periodontal adhesive bandages, characterized in that the bandage further treated surface of the cement teeth in the area of inflammation citric acid solution with the concentration of 0.1 mol/l for 5 min, and then 0,06%chlorhexidine solution and the mixture Nikiforova, then as periodontal adhesive bandage impose Sulfacrylate in the periodontal pocket with subsequent effects on inflammation ultrasound frequency of 26.5 kHz within 3 seconds



 

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6 tbl

FIELD: medicine, urology.

SUBSTANCE: at first, it is necessary to wash urinary bladder's cavity with ozone/NO-containing physiological solution. Then, 1-3 min later one should evacuate the worked out solution and introduce ozonide/NO-containing butyric "oil-in-water" emulsion into urinary bladder's cavity. Cavitary sonication should be carried out through the solution with low-frequency energy at 26.5 kHz frequency and fluctuation amplitude being about 60-80 mcm for 1-2 min. The worked out solution should be evacuated. Urinary bladder's cavity should be refilled in with fresh solution of ozonide/NO-containing butyric "oil-in-water" emulsion. One should affect with low-frequency ultrasound at fluctuation frequency of 44 kHz and amplitude of 25-30 mcm due to external contact impact upon the tissues of anterior abdominal wall in area of urinary bladder's projection. Moreover, it is necessary to simultaneously bubble the emulsion solution with ozone/NO-containing gaseous mixture for 1 min followed by aeration of urinary bladder's cavity with ozone/NO-containing gaseous mixture for 1 min. Application of such complex therapy enables to decrease urethral traumatism , intensify regional blood and lymph circulation in the area of urinary bladder, create the depot of medicinal preparation in tissue layers of urinary bladder's wall and fulfill sanitation of urinary bladder's walls.

EFFECT: higher efficiency of therapy.

4 dwg, 2 ex

FIELD: medicine, plastic surgery.

SUBSTANCE: the present innovation deals with carrying out cosmetological surgical interferences for removing local fatty depositions that deform body contours. One should perform presurgical survey of a patient followed by roentgenograms, roentgenography of thoracic area or fluorography, electrocardiography and inspecting the function of external respiration. Application of contours and borders of surgical field at patient's standing position along with detecting the thickness of subcutaneous-fatty fiber and areas with cellulites, at analysis of the already protruded cavities and, also, the sites of desired incisions. Moreover, the protruding areas of liposuctioning should be marked with a "+" symbol, as for the areas of cavities and defects of a patient's body contours - with a "-" sign. The desired volume of anesthesiological manual should be fulfilled depending upon the number of operated areas, their localization and the volume of the removed subcutaneous-fatty fiber. Transcutaneously one should make incisions along the edge of liposuctioning of about 5-8 mm length to introduce through them an infiltration cannula of 2 mm diameter with foramens located at its end. Under manual control it is necessary to perform steady infiltration of subcutaneous-fatty fiber due to introducing an infiltration cannula through these foramens under the pressure being 0.4-0.6 Bar at the rate of 80-100 ml/min of tumescent solution being heated up to 37-38°C. Reciprocatingly it is necessary to replace the infiltration cannula in the volume of fatty fiber in every individually formed tunnel of fan-shaped net of closely connected infiltration tunnels and saturating it with tumescent solution to create local intra-cellular hyperhydration of lipocytes. About 10-15 min after the onset of infiltration one should widen the site of puncture or incision with the help of a blunt dilator. Trocar with a protective silicon interlayer should be applied to introduce through it a titanium hollow probe of ultrasound apparatus. Then comes ultrasound destruction of fatty cells at a probe's uninterrupted linear movement in the layer of fatty fiber along with a probe's reciprocating movement at the rate of 40-50 movements/min in each developed tunnel and at simultaneous suction of the developed fatty detritus of emulsified adipocytes out of liposuctioning area through the foramens of the canal of ultrasound probe of about 3-4 mm diameter at using negative pressure of 0.2-0.3 Bar. Ultrasound impact upon subcutaneous-fatty fiber should start in every developed tunnel first, from inferior layers of subcutaneous-fatty acids and subsequent transition after the suction of the developed fatty detritus onto above-lying layers of subcutaneous-fatty fiber. On finishing the operation one should apply aseptic bandages and compression linen. Wounds should be bandaged in post-surgical period due to applying antiseptic solutions and water-soluble ointments along with the intake of non-narcotic analgetics, sedative preparations and antibacterial therapy with antibiotics for 4-7 d after the operation. The method decreases the risk of undesired skin traumatism and damage of surrounding vessels and nerves and, also, exclude the damage in surrounding structures and obtain maximal effect of "skin lifting" and accelerate the process of rehabilitation.

EFFECT: higher efficiency.

11 cl, 3 ex

FIELD: medicine, immunology.

SUBSTANCE: invention relates to non-medicinal prophylaxis of post-surgery immunodeficiency states. Method involves every day treatment by ultrasonic by labile procedure on the manubrium sternum region at intensity 0.05 Wt/cm2 with a single exposition for 2-2.5 min. In 10 min after sonication treatment the lumbar region is subjected for similar treatment in a single exposition for 3-4 min for 2-3 procedures for treatment course. After ultrasonic treatment a patient is subjected for necessary surgery operation. Method provides reducing time for pre-surgery preparing and carrying out prophylaxis of post-operation immunodeficiency states in planning surgery operations with retained effectiveness.

EFFECT: improved method for prophylaxis.

1 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: method involves introducing photosensitizer, recording level of its accumulation in tumors, carrying out photodynamic therapy. Pyrogenal is introduced at a dose of 40-1000 mkg/csm2 before introducing photosensitizer into the tumor base with tumor temperature being recorded until stable tumor tissue hyperemia being achieved for 12-24 h. Then, the tumor is smeared with composition containing 3-10 mg of photosensitizer, gel "Ultramix" and 20-200 mcg of Pyrogenal. Treatment with ultrasound is applied with intensity 0.2-0.4 W/cm2, in labile continuous mode within 5-8 min. The composition is left on skin for 1-2 h. Then, photodynamic therapy session is uniformly carried out over the whole tumor area, with total number of 3-5 procedures per treatment course.

EFFECT: enhanced effectiveness of treatment; prolonged optimum photosensitizer dose being supported in tumor, sufficient for effective photodynamic therapy action.

The invention relates to medicine, in particular to the gynecologist, and can be used to treat ovarian cysts
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