Vaginal homeopathic suppository "b antikan" (variants)

FIELD: medicine, chemical-pharmaceutical industry, homeopathy, gynecology.

SUBSTANCE: invention relates to creature of novel vaginal homeopathic suppository that can be used in treatment of female genitals. Invention proposes nine variants of homeopathic suppository containing sea-buckthorn oil, homeopathic oily extract, oils and homeopathic essences. Proposed suppositories possess the enhanced bioavailability based on addition of homeopathic oily extract in the prescription, improve regenerative function of organs and tissues and enhance effect of basic components that allows their using in homeopathy in treatment of fungal colpitis, vulvovaginitis, endometriosis and papillomas.

EFFECT: improved and valuable medicinal properties of suppository.

9 cl, 20 ex

 

The invention relates to pharmaceutical industry and relates to the creation of new homeopathic suppositories, which can be used to treat fungal obesity, vulvovaginitis, endometriosis, papillomas, fibroids. Well-known medication for the treatment of inflammatory diseases of female genital organs.

Vaginal suppositories for the treatment of Trichomonas and nespetsificheskogo of obesity (Patent RU № 2114610), which include chemical nitazol.

Suppositories with antifungal activity (Patent RU № 2139707), which contain the active substances of a chemical nature.

The disadvantage of these analogues is that the presence of rectal suppositories active substances chemical nature can cause a number of complications, and lead to the development of dysbiosis and the manifestation of a fungal infection.

Recently, a very wide application find homeopathic medicines, based on the use of drugs in small doses. Homeopathic medicines do not have a toxic effect and will not damage the liver and kidneys, and also not affect the normal flora of the body.

The closest technical solution to the claimed are homeopathic suppositories "gemeprost" (RU Patent No. 2256462, bull. No. 20 of 20.072005,), which is used for the treatment of cervical erosion and endometritis.

Homeopathic suppositories contain propolis, homeopathic essences chestnut 0,1, Ginkgo biloba 0,1, aloe 0,1, yarrow 0.1, anhydrous lanolin 0.15, beeswax. The disadvantages of this prototype can be attributed to the presence of a much larger number of homeopathic essences, than can be collected in the basis and the lack of oil extracts, which affects the quality candles and hinders the absorption of active substances from medicinal forms.

The technical task of the present invention is to provide a composition homeopathic candles with improved texture, increased absorption of active substances, as well as expanding the range of validity of suppositories.

This object is achieved by introducing in the prescription of homeopathic oil extract, which provides improved consistency of candles due to the fact that the oil included in the composition, will take out an excess of alcoholic extract, which increases the action of the main components.

Improved regenerative function of organs and tissues due to the cushioning effect of the oil extract.

Offers nine options candles, used to treat fungal obesity, vulvovaginitis, endometriosis, papillomas, fibroids.

the first version of the medicinal product is a suppositories, addition of sea buckthorn oil (FS 42-17730-95)additionally contain homeopathic essences of eucalyptus, elderflower, sage, oil of thuja, tea tree oil, juniper oil, homeopathic oil extract, cocoa butter, beeswax, propolis, lanolin with the following components in grams per 1 candle weighing 2.0 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Oil of thuja0,1
Tea tree oil0,1
Juniper0,1
Homeopathic essence of eucalyptus0,1
Homeopathic essence elderflower0,1
Homeopathic essence of wormwood0,1
Cocoa butter0,6
Beeswax0,15
Propolis0,15
Lanolin0,1

The second option is a suppositories containing sea buckthorn oil, homeopathic oil extract, tea tree oil, oil of thuja, juniper homeopathic essence of calendula homeopathic essence of mistletoe, gomeopatichesky the th essence of Chelidonium, cocoa butter, beeswax, propolis, lanolin with the following ratio of components, candle mass of 2 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Tea tree oil0,05
Oil of thuja0,1
Juniper0,1
Homeopathic essence of calendula0,05
Homeopathic essences Chelidonium0,05
Homeopathic essence of mistletoe0,1
Cocoa butter0,69
Beeswax0,17
Propolis0,17
Lanolin0,12

A third option suppositories has a composition that, in addition of sea buckthorn oil contains homeopathic oil extract, oil of thuja, juniper, tea tree oil, homeopathic essences oregano, eucalyptus, cocoa butter, beeswax, propolis, lanolin under the following ratios of components in g on a candle by weight of 2 g:

Sea buckthorn0,2
Homeopathic oil extract 0,2
Oil of thuja0,1
Juniper0,1
Tea tree oil0,1
Homeopathic essence of oregano0,1
Homeopathic essence of eucalyptus0,1
Cocoa butter0,66
Beeswax0,165
Propolis0,165
Lanolin0,11

The fourth option suppositories, addition of sea buckthorn oil contains homeopathic oil extract, calendula oil, oil of the herb, homeopathic essences of mistletoe, mugwort extract, lakones, elderberry, cocoa butter, beeswax, propolis, lanolin in the following ratio of ingredients in grams per candle by weight of 2 g:

Sea buckthorn0.2
Homeopathic oil extract0,2
Calendula oil0,05
Oil celandine0,05
Homeopathic essence of mistletoe0,1
Homeopathic essence of wormwood0,1
Homeopathic essence lakones0.1
Homeopathic essentialine 0,1
Cocoa butter0,66
Beeswax0,165
Propolis0,165
Lanolin0,11

The fifth option suppositories, in addition, sea buckthorn contains homeopathic oil extract, oil of the herb, oil of thuja, homeopathic essences of mistletoe, dandelion, elderberry, Chelidonium, cocoa butter, beeswax, propolis, lanolin in the following ratio of components in g on a candle by weight of 2 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Oil of thuja0,1
Oil celandine0,05
Homeopathic essence of mistletoe0.1
Homeopathic essence of dandelion0,1
Homeopathic essence of the elder0,05
Homeopathic essences Chelidonium0,05
Cocoa butter0,69
Beeswax0,17
Propolis0,17
Lanolin0,12

The sixth option suppositories, addition of sea buckthorn oil contains gomeopaticheskii oil extract, oil of juniper, oil of the herb, patchouli oil, homeopathic essences sumac, Kantaris, cocoa butter, beeswax, propolis, lanolin in the following ratio of components in g on a candle by weight of 2 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Juniper0,05
Oil celandine0,05
Patchouli oil0,01
Homeopathic essence of poison ivy0,1
Homeopathic essence of Kantaris0,1
Cocoa butter0,78
Beeswax0,19
Propolis0,19
Lanolin0,13

The seventh option suppositories, addition of sea buckthorn oil contains homeopathic oil extract, Melissa oil, oil of hops, Valerian oil, homeopathic essences of mistletoe, jaborandi, cocoa butter, beeswax, propolis, lanolin, in the following ratio of ingredients in grams per suppository mass of 2 g:

Sea buckthorn0,2
Homeopathic oil extract 0,2
Oil of lemon balm0,05
Oil of hops0,05
Oil of Valerian0,05
Homeopathic essence of mistletoe0,2
Homeopathic essence of jaborandi0,2
Cocoa butter0,63
Beeswax0,16
Propolis0,16
Lanolin0,1

The eighth option suppositories, addition of sea buckthorn oil contains homeopathic oil extract, tea tree oil, oil of dandelion, homeopathic essences calendula, pulsatila, eucalyptus, cocoa butter, beeswax, propolis, lanolin in the following ratio of ingredients in grams per suppository mass of 2 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Tea tree oil0,05
Oil dandelion0,05
Homeopathic essence of calendula0,1
Homeopathic essences pulsatila0,1
Homeopathic essence of eucalyptus0,1
Cocoa butter/td> 0,72
Beeswax0,18
Propolis0,18
Lanolin0,12

The ninth option suppositories, addition of sea buckthorn oil contains homeopathic oil extract, homeopathic essences Likopodija, homeopathic essences of Kantaris, cocoa butter, beeswax, propolis, lanolin in the following ratio of ingredients in grams per suppository mass of 2 g:

Sea buckthorn0,2
Homeopathic oil extract0,2
Homeopathic essence Likopodija0,2
Homeopathic essence of Kantaris0,1
Cocoa butter0,78
Beeswaxof € 0.195
Propolisof € 0.195
Lanolin0,13

In homeopathy apply essences prepared from equal parts of juice and 90% ethyl alcohol(Wilmar Schwabe. Homeopathic medicines. A guide to description and manufacturer. Edited Whirinaki. M., 1967, p.15-16).

All the proposed formulations of medicinal plants known and used in homeopathy. All salaamislam aimed at solving the same problem - the increased bioavailability and improved consistency of candles, improving the regenerative functions of the organs and tissues and enhanced activity of the main components, as well as expanding the range of validity of suppositories.

Technology homeopathic oil extract is as follows: an equal number of fruits 0.5 g of sea buckthorn, grass, clover, grass, sage, flowers of acacia pour 95° alcohol in a ratio of 1:2 (4 ml) to mirrors for 24 hours, then add olive oil (4 g), steamed in a water bath for 6-8 hours. Filtered. The basis for candles made from cocoa butter, beeswax, propolis, lanolin, as follows.

100 g basis separately melt 15 g of propolis in a water bath to dissolve in hot filter. Separately melt 15 g beeswax with 30 g of cocoa butter to dissolve and immediately filtered. In this hot weight enter hot propolis. And get the mixture (oil, beeswax). Then 30 g of boiling cocoa butter injected the mixture (oil, beeswax), a little cool and add 10 g of lanolin, mix until completely cooled.

A specific example of the suppository composition No. 1

Composition in g / candle mass of 2.0,

Sea buckthorn 0,2, homeopathic oil extract of 0.2, oil of thuja 0,1, tea tree oil 0,1, juniper 0,1, homeopathic Essen the Oia eucalyptus 0,1, homeopathic essence elderflower 0,1 homeopathic essence of wormwood 0,1, fundamentals of 1.0,

Pre-made, as described above, the basis of suppositories homeopathic oil extract, then homeopathic essences triturated with 0.5 g basis, then in the remaining 0.5 g of molten basics add oils and homeopathic oil extract at a temperature of oils 37°C, the mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

A specific example of a variant of the suppository composition No. 2

Composition in g on 1 suppository mass 2,

Sea buckthorn 0,2, homeopathic oil extract of 0.2, tea tree oil 0.05, the oil of thuja 0,1, juniper 0,1, homeopathic essence of calendula 0,05, homeopathic essences Chelidonium of 0.05, homeopathic essence of mistletoe 0,1, fundamentals of 1.15

Homeopathic essences grind with 0.6 g of foundations, prepared in advance. Then 0.6 g of the remaining bases grind with homeopathic oils. The resulting mixture are combined and admixed homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or VL is Stasova forms.

A specific example of the suppository composition No. 3.

Composition in g on 1 suppository mass 2,

Sea buckthorn 0,2, homeopathic oil extract of 0.2, oil of thuja 0,1, juniper 0,1, tea tree oil 0,1, homeopathic essences oregano 0,1, homeopathic essence of eucalyptus 0,1, fundamentals of 1.1.

Homeopathic essences triturated with 0.5 g basis, prepared in advance. Then 0.6 g of pound basis with homeopathic oils. The resulting mixture are combined and admixed homeopathic oil extract, warmed to 37°

A specific example of the suppository composition No. 4.

Composition in g / candle mass 2,

Sea buckthorn 0,2, homeopathic oil extract of 0.2, calendula oil to 0.05, oil celandine 0,05 homeopathic essences mistletoe 0,1, wormwood 0.1, lakones 0,1, elderberry 0.1, the basis of 1.1.

Homeopathic essences triturated with 0.5 g basis, prepared in advance. Then 0.4 g of pound basis with homeopathic oils and mix homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

A specific example of the suppository composition No. 5.

Composition in g / candle mass 2,

Sea buckthorn 0,2, Goma is Patitucci oil extract 0,2, oil celandine 0.05, the oil of thuja 0,1 homeopathic essences mistletoe 0,1, dandelion 0,1, elderberry 0.05, Chelidonium of 0.05, fundamentals of 1.15. Homeopathic essences grind with 0.6 g of foundations, prepared in advance. Then 0.65 g bases grind with homeopathic oils and mix homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

A specific example of the suppository composition No. 6.

Composition in g / candle mass 2,

Sea buckthorn 0.2, homeopathic oil extract 0.2, juniper 0.05, the oil of the herb is 0.05, patchouli oil 0,01, homeopathic essences sumac 0,1, Kantaris 0,1, fundamentals of 1.1. Homeopathic essences triturated with 0.5 g basis, prepared in advance. Then 0.6 g of the basics admixed homeopathic oils and homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

Specific example No. 7

Sea buckthorn 0,2, homeopathic oil extract of 0.2, Melissa oil 0.05, the oil of hops 0.05, the oil of Valerian 0.05, homeopathic essence of mistletoe is Eloy 0,2, homeopathic essence of jaborandi 0,2, fundamentals of 1.05

Homeopathic essences triturated with 0.5 g basis, prepared in advance. Then 0.55 g of the basics admixed homeopathic oils and homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

Specific example No. 8

Sea buckthorn 0,2, homeopathic oil extract of 0.2, tea tree oil is 0.05, oil dandelion 0,05, homeopathic essence of calendula 0,1, homeopathic essences pulsatile 0,1, homeopathic essence of eucalyptus 0,1, fundamentals 1,2

Homeopathic essences grind with 0.6 g of foundations, prepared in advance. Then 0.6 g of the basics admixed homeopathic oils and homeopathic oil extract, warmed to 37°C. the Mixture is thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

Specific example No. 9

Sea buckthorn 0,2, homeopathic oil extract of 0.2, homeopathic essence Likopodija 0,2, homeopathic essence of Kantaris 0,1, base 1,3

Homeopathic essences ground with 0.7 g of foundations, prepared in advance. the ATEM to 0.6 g bases admixed homeopathic oils and homeopathic oil extract, warmed up to 37°Ssmes thoroughly mixed among themselves until a homogeneous mass. Suppositories are prepared by the method of splashing in a special metal or plastic forms. The proposed formulations homeopathic suppositories have the following physico-chemical characteristics (GF XI issue 2, s article "suppositories"):

The full deformation of not more than 7 minutes

Melting point not higher 33,5°

The acid number of not more than 4.0 mg KOH

The increased bioavailability of the proposed formulations was determined by in vitro method. In a device for diffuse release, which is a glass tube with a length of 15 cm, a cross section of 10 cm2on one end which attach the cellophane membrane and immersed to a depth of 2-3 cm with ringer's solution. After reaching a temperature of 37°With cellophane membrane omit the suppository. Sampling was performed using the pipette at regular intervals of time (Technology of drugs. Yourable, M., 1980, vol. 1 str).

Conducted chemical analyses of the samples showed that, compared with the prototype of the active chemicals from the proposed suppositories are released faster. Therapeutic activity of the proposed formulations of suppositories were studied on the basis of the homeopathic center "Verbena" Pyatigorsk.

Example 1

Patient Abtomat the VA, H.E., 1953. He complained of lower back pain. Frequent urination, Beli.

The diagnosis of fungal colpitis for everybody.

Purpose: candle composition No. 1 by one candle in the morning and at night for 1 month.

The dynamics of the disease: after 5 days disappeared back pain, urination returned to normal. After 10 days of application disappeared Beli, improved health.

Re turnout in 20 days. After inspecting the mucosa was normal.

Example # 2

Koresheva V.M., 1959.

The diagnosis of fibroids 10 weeks, painful menstrual cycle is delayed by 5-7 days, dragging pain in the lower abdomen. Purpose: Candle composition No. 1 in the morning and evening for 1 month. The dynamics of the disease: Feel better after 5 days of candles, dragging pain in the abdomen disappeared. After 10 days of application, the delay was reduced to 2 days. Re turnout in 20 days. After the ultrasound showed reduction of fibroids up to 7-8 weeks. Repeat the treatment after 10 days, according to the same scheme.

Example # 3

Patient Egorova LT, born in 1960.

Diagnosis: candidiasis, endometriosis, pain during menstrual cycle.

Purpose: candle composition No. 2 in the morning and in the evening, one candle deep into the vagina for 1 month.

The dynamics of the disease: Feel better after 5 days of candles, pain is Shazli. After re-admission noted positive dynamics of treatment, mucous came back to normal after 10 days of candles. After the ultrasound the observed decrease in proliferation of the endometrium.

Example No. 4

Sick of Supercena GI, 1967.

Diagnosis: yellowish-brown discharge, warts, fungal colpitis.

Purpose: candle composition No. 2 in the morning and in the evening, one candle deep into the vagina for 1 month.

The dynamics of the disease: Feel better after 5 days of candles, the selection is gone. After re-admission noted positive dynamics of treatment, mucous came back to normal after 10 days of candles. After treatment papilloma decreased, the mucosa was normal.

Example No. 5

Patient Zakharchenko L.V. born in 1961

Diagnosis: uterine fibroids 7 weeks. frequent urination.

Purpose: Candle composition No. 3 in the morning and in the evening, one candle for 1 month.

The dynamics of the disease: feel better on the 7 day candles, urination is normal. After treatment ultrasound showed a reduction in fibroids to 3 weeks.

Example No. 6

Patient Ovcharova E.A. 1959 birth.

Diagnosis: Fungal colpitis, endometriosis. Yellowish discharge.

Purpose: Candle composition No. 4 in the morning and in the evening, one candle within 30 days.

The dynamics of the disease: After five and days of treatment disappeared selection.

After 15 days of treatment was the reduction of proliferation of the endometrium. After treatment ultrasound said suspension proliferation of the endometrium, feeling good.

Example No. 7

Patient soricina I.G., born in 1966.

Diagnosis: complaints of feeling of suffocation. Weakness, lethargy, fatigue. The change of the thyroid gland. Endometriosis. Selection serous, grayish-brown.

Purpose: Hormone therapy. Candle composition No. 5 in the morning and in the evening, one candle within 30 days.

The dynamics of the disease: After five days of treatment disappeared selection. After 15 days of treatment was the reduction of proliferation of the endometrium. After treatment ultrasound said suspension proliferation of the endometrium, feeling good.

Example No. 8

Sick Vorwort VI

Diagnosis: fungal colpitis, complaints of itching, discharge.

Purpose: Candle composition No. 6 in the morning and in the evening, one candle within 30 days.

The dynamics of the disease: On the fifth day of treatment was stopped itching. On day 10 of treatment allocation have stopped. The treatment was continued.

After treatment mucosa was normal.

Example No. 9

Patient: Kormangala N.A., 1967 birth.

Diagnosis: the menstrual cycle for 2-4 months, pulling back pain, endometriosis, everybody.

Purpose: Candle composition No. 7 in the morning and evening on the ne candle within 30 days.

The dynamics of the disease: On day 5 of treatment nagging lower back pain stopped. Treatment was continued. On day 10 of treatment mucosa was normal. After treatment restored menstrual cycle. After treatment ultrasound noted a reduction in the proliferation of the endometrium

Example No. 10

Patient Sarkisova T. B. 1962.

Diagnosis: a single papilloma external genital organs vulvovaginitis, complaints of itching.

Purpose: Candle composition No. 8 in the morning and in the evening, one candle deep in the cavity.

The dynamics of the disease: Itching stopped on day 6 of treatment. On the 12th day mucosa was normal. After treatment the patient is healthy.

Example No. 11

Patient Shabanova A.S. 1959 birth

Diagnosis: Endometriosis, fibroids to 4 weeks., colpitis, dragging pain in the abdomen.

Purpose: Candle composition No. 9 on one candle 2 times a day for 30 days.

The dynamics of the disease: Pain disappeared on day 5 of treatment. On day 10 normal mucosa. After treatment ultrasound noted a reduction in the proliferation of the endometrium and reducing the fibroid to 3 weeks. Re-admission after one month showed that the growth of the endometrium is stopped. Thus, we can conclude that the proposed compositions have a high bioavailability and can be used in homeopathy for the treatment of diseases such as obesity, vulvovaginitis, endometriosis, papilloma, fibroids.

1. The homeopath is ical suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences of eucalyptus, elderflower and wormwood, oil of thuja, tea tree oil, juniper oil, homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal quantities, and the basis for the following components in grams per 1 candle weighing 2.0 g:

sea buckthorn0,2
homeopathic oil extract0,2
oil of thuja0,1
tea tree oil0,1
juniper0,1
homeopathic essence of eucalyptus0,1
homeopathic essence elderflower0,1
homeopathic essence of wormwood0,1
baserest

2. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences marigold, mistletoe and Chelidonium, tea tree oil, oil of thuja, juniper, Homeo eticheski oil extract, including sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis for the following components in grams per 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
tea tree oil0,05
oil of thuja0,1
juniper0,1
homeopathic essence of calendula0,05
homeopathic essences Chelidonium0,05
homeopathic essence of mistletoe0,1
baserest

3. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences of oregano and eucalyptus, oil of thuja, juniper, tea tree oil homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis for the following components in grams per 1 candle by weight of 2 g:

sea buckthorn
0,2
homeopathic oil extract0,2
oil of thuja0,1
juniper0,1
tea tree oil0,1
homeopathic essence of oregano0,1
homeopathic essence of eucalyptus0,1
baserest

4. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences of mistletoe, mugwort extract, lacunosa and elder, calendula oil, oil of the herb, homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of ingredients in grams of 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
calendula oil0,05
oil celandine0,05
homeopathic essence of mistletoe0,1
homeopathic ESS is ncia wormwood 0,1
homeopathic essence of lacunosa0,1
homeopathic essence of the elder0,1
baserest

5. Homeopathic suppositories for the treatment of fungal diseases of obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences of mistletoe, dandelion, elderberry and Chelidonium, the oil of the herb, oil of thuja, homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of components in grams per 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
oil of thuja0,1
oil celandine0,05
homeopathic essence of mistletoe0,1
homeopathic essence of dandelion0,1
homeopathic essence of the elder0,05
homeopathic essences Chelidonium0,05
baserest

. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences sumac and Kantaria, oil of juniper, oil of the herb, patchouli oil, homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of components in grams per 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
juniper0,05
oil celandine0,05
patchouli oil0,01
homeopathic essence of poison ivy0,1
homeopathic essence of Kantaris0,1
baserest

7. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences of mistletoe, jaborandi, Melissa oil, oil of hops, Valerian oil, homeopathic oil extract, including fruits oblem is hee, grass clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of ingredients in grams of 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
oil of lemon balm0,05
oil of hops0,05
oil of Valerian0,05
homeopathic essence of mistletoe0,2
homeopathic essence of jaborandi0,2
baserest

8. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, containing sea buckthorn oil, homeopathic essences calendula, pulsatile and eucalyptus oil, tea tree oil, dandelion homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of ingredients in grams of 1 candle weighing 2.0 g:

sea buckthorn0,2
homeopathic oil extract0,2
oil cha the aqueous wood 0,05
oil dandelion0,05
homeopathic essence of calendula0,1
homeopathic essences pulsatila0,1
homeopathic essence of eucalyptus0,1
baserest

9. Homeopathic suppositories for the treatment of fungal obesity, vulvovaginitis, endometriosis, papillomas, characterized in that they contain sea buckthorn oil, homeopathic essences Likopodija and Kantaria, homeopathic oil extract, containing sea-buckthorn berries, grass, clover, herb, sage and acacia flowers, taken in equal amounts and the basis of the following ratio of ingredients in grams of 1 candle by weight of 2 g:

sea buckthorn0,2
homeopathic oil extract0,2
homeopathic essence Likopodija0,2
homeopathic essence of Kantaris0,1
baserest



 

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SUBSTANCE: the present innovation deals with the ways for applying the means of external application for preventing vaginal dysbacteriosis, in preparing the patients before gynecological manipulations. It is necessary to apply bacterial composition that normalizes vaginal microflora and contains lactose or lactulose and/or lactic or citric acid, a gel-forming agent, a moisturizing agent, a conservant and water at the following ratio of components, weight%: lactose or lactulose 25.00, not more; and/or lactic or citric acid 1.00, not more; a gel-forming agent 1.50, not more; a moisturizing agent 6.00-30.00, a conservant 0.30, not more; water - up to 100. The variant of vaginal composition can additionally contain: at least, one biologically active additive 0.01-2.00; an antiseptic component 0.50, not more. The innovation provides prophylaxis of vaginal dysbacteriosis due to normalizing the microflora of female reproductive organs; prolonged contact of this composition with mucosa additionally realizes regenerative, wound healing, protective, disinfective action; it, also, provides harmonization of intimate relations by removing unpleasant feelings during coitus due to the presence of moisturizing and lubricating action of the present composition.

EFFECT: higher efficiency of prophylaxis.

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2 ex

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to new chemical compound of general formula I , or salts, or hydrates thereof. In formula I R1 represents group of formula -G1-R1a (wherein G1 represents single bond, oxygen, sulfur; R1a represents C1-C10-alkyl optionally substituted with halogen or C3-C8-cycloalkyl); R2, R3 and R4 are independently hydrogen or -G20-R20 (wherein G20 represents single bond, oxygen, sulfur, sulfinyl or sulfonyl; R20 represents C1-C6-alkyl optionally substituted with 1-3 halogen atoms or C3-C8-cycloalkyl); R5 and R6 are independently -X5-X6-X7 group (meanings of X5, X6 and X7 are as defined in specification) or R3 and R4 may together form pyrrol ring optionally substituted with C1-C6-alkyl; Ar represents phenyl, 1,3-benzodioxolyl, naphthyl, pyridyl, optionally substituted with 1-3 substituents (as defined in specification) Compounds of formula I has antagonistic activity in relates to receptors of corticotrophin releasing factor (CRF). Also disclosed are compounds, characterized by preferable structures, pharmaceutical compositions, using such compounds, intermediates for production thereof and method for treatment of various diseases mediated by CRF.

EFFECT: new compounds as antagonists of CRF receptors.

33 cl, 1 tbl, 316 ex

FIELD: medicine.

SUBSTANCE: method involves administering clay applications to anterior abdominal wall in uterine projection and appendages area for 40-50 min. Then, clay is introduced into vagina as tampon for 90-120 min. Clay temperature is equal to 22-24°C when used in procedures applied once a day. The total treatment course is 8-10 days long.

EFFECT: enhanced effectiveness in activating humoral immunity; marked anesthetic and anti-inflammatory action; reduced risk of chronic inflammatory process exacerbation.

FIELD: medicine, urology, sexopathology.

SUBSTANCE: about 4-5 wk after the trauma it is necessary to introduce Impaza for a patient per 1 tablet before meals in the morning during 1-2 month every other day. Then during 5-6 month additionally during the days between Impaza intake it is necessary to introduce Levitra at the dosage of 5 mg after meals in the morning twice or thrice weekly. Then Levitra intake should be stopped to continue Impaza intake for 1-2 mo more. Due to the scheme of stage-by-stage introduction of medicinal preparations the innovation prevent the hemorrhage out of traumatic areas and, also, the development of ischemia and fibrosis of cavernous bodies at early stages after urethral trauma.

EFFECT: higher efficiency of therapy.

6 dwg, 2 ex

FIELD: chemical and pharmaceutical industry.

SUBSTANCE: : claimed oil represents mixture of essential oils and jojoba fatty oil, wherein essential oil contains lemongrass, geranium, Litsea cubeba, calamus root, tobacco, jasmine, limette, eucalyptus, ginger, thyme, bay laurel, cypress, bergamot, cinnamon, clove, juniper, and oil from Myrcia caris.

EFFECT: effective oil for increasing of sexual potency.

FIELD: medicine.

SUBSTANCE: method involves administering Tamoxifen and Zoladex during the whole therapy course.

EFFECT: cut-off ovary functioning; inhibiting estrogen action upon tumor tissue; no adverse side effects observed.

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: Described are derivatives of general formula I (all symbols are as described in specification), pharmaceutically acceptable salts thereof or cyclodextrin clathrates. Such compounds hardly bind of EP2 subtype of PGE receptor and are useful in prophylaxis of immune diseases, allergy, death of neuronal cells, liver or kidney insufficiency, etc.

EFFECT: new agent for prophylaxis of various diseases.

18 cl, 388 ex, 68 tbl, 3 dwg

FIELD: medicine, gynecology.

SUBSTANCE: at the first stage it is necessary to introduce a protein-vitamin complex "Kedrovaya sila" ("Cedar power") per 1 table spoon thrice daily for 1 mo, moreover, for about 5-7 d one should inject antibiotic under vaginal musosa at ¼ daily dosage, and a suppository with trypsin rectally. Then, in 15 min it is important to carry out physiotherapy with sinusoidal modulated currents. At the second stage a woman should be inspected by otorhinolaringologist and gastroenterologist and according to indications specialized testing and therapy should be carried out. At the third stage during 3 mo it is necessary to follow cyclic vitaminotherapy. In the first half of menstrual-ovarian cycle one should prescribe vitamin B6 per 0.015 g daily; folic acid 0.03 g. During the second half of the cycle one should introduce vitamin C 0.3-0.5 g thrice daily and capsulated cedar oil with vitamin E per 2 capsules thrice daily. Moreover, during 6 mo one should prescribe adaptogens: eleutherococcus, or leusea, golden root, or ginseng tincture under standard dosages. The innovation provides normalization of biochemical, immune and hormonal indices, reconstruction of reproductive function and the absence of relapses during 3 yr.

EFFECT: higher efficiency of prophylaxis and therapy.

1 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I) and their pharmaceutically acceptable salts and/or pharmaceutically acceptable esters. Proposed compounds possess properties of agonists of receptors activated by peroxisome proliferators (PPAR agonists) and can be used in treatment of such diseases as diabetes mellitus, hypertension, atherosclerotic diseases and others. In the general formula (I) R1 represents phenyl, optionally mono-, di- or tri-substituted with halogen atom, lower alkyl, fluorine-lower alkyl, lower alkoxy-group; R2 represents hydrogen atom or lower alkyl; R3 and R4 represents independently of one another hydrogen atom, hydroxy-group, halogen atom, lower alkyl, fluorine-(lower alkyl), lower alkoxy-group wherein at least one of radicals R3 and R4 doesn't represent hydrogen atom; R5 represents lower alkoxy-group; R6 represents hydrogen atom or lower alkyl; n = 1. Also, invention relates to a pharmaceutical composition based on compounds of the invention.

EFFECT: valuable medicinal properties of compounds.

19 cl, 1 tbl, 7 sch, 56 ex

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: the present innovation deals with developing new medicinal preparations for treating urogenital diseases. The suggested preparation for treating prostatic diseases designed as a suppository that contains the complex of bioregulatory peptides of cattle prostate as a powder with the content of water-soluble peptides being 20%, not less and the foundation, moreover, antimicrobial preparation being the antibiotic or anti-viral preparation, or anti-protozoan preparation, or the mixture of antibiotic and anti-protozoan preparation taken at 1:1 ratio, or the mixture of anti-viral and anti-protozoan preparation taken at 1:1 ratio and the foundation at the following ratio of the components, g/suppository: complex of bioregulatory peptides of cattle prostate 0.05-0.4; antimicrobial preparation 0.7, not more; the foundation - sufficient quantity to obtain the suppository of 2.15-2.35 g weight. The suggested preparation in the form of suppository is of high level of organotropic activity and high level of antimicrobial action that enables to implement etiotropic and pathogenetic therapy of bacterial prostatitis. The innovation provides the action upon an agent and all pathological processes in the affected organ. The innovation enables to treat bacterial prostatic inflammation and that of functionally associated organs.

EFFECT: higher efficiency of therapy.

4 cl, 132 ex, 32 tbl

FIELD: chemical-pharmaceutical industry.

SUBSTANCE: it has been suggested to apply a solid composition for manufacturing a pharmaceutical tablet or a suppository, its melting point being 25°C or higher and it contains an uninterrupted lipid component that contains either one or more than one galactolipids, one or more glyceride ether of fatty acids, possibly one or several out of the following: water and mono-triatomic alcohol at the quantity being up to 15 weight% against the weight of composition, and one or more agent chosen among pharmacologically active agent. The method for manufacturing the composition mentioned includes mixing galactolipids and glyceride ethers of fatty acids followed by dissolving pharmacologically active agents in a liquid phase, cooling up to a solid state and forming a tablet or a filled capsule. Pharmaceutical tablet or suppository are depicted that include uninterrupted lipid phase possibly containing an inert nucleus and, also, food tablets or suppositories of similar composition that include food agents instead of pharmacologically active agent and, possibly, having got one or more submembranes consisting of food excipients. The innovation provides economy and increased comfort in usage.

EFFECT: higher efficiency.

42 cl, 13 ex, 10 tbl

FIELD: microbiology, biotechnology, medicine, in particular production of living vaccines against viral infections.

SUBSTANCE: invention relates to living vaccines for rectal administration against viral infections based on attenuated recombinant Salmonella strains bearing protective viral antigens. Suppository for immunoprophylaxis of viral infections contains (per one 2 g suppository, mass %): cell slurry of attenuated recombinant Salmonella strains transformed with pGEX-2T-TBI, pcDNA-TCI, or pKHBc bearing gene of protective viral antigens, mixed with suppository base in amount of 106-109 living cells 1 %; fatty base 94 %; and emulsifier T2 5 %. As fatty solid cooking oil (94 %); or hydrolyzed cotton oil (94 %); or mixture of cooking oil (60 %), Cocoa fat (24 %), and solid wax (10 %).

EFFECT: agent for inducing of humoral and cell immune response to respective viral antigen.

8 tbl, 11 ex, 3 dwg

FIELD: medicine, gynecology, proctology, pharmacy.

SUBSTANCE: invention relates to medicaments made as vaginal and rectal suppository used in treatment of proctological, non-inflammatory and inflammatory diseases of female pelvis organs, among them complicated with suppurative-inflammatory processes. Invention relates to an agent used in treatment of gynecological and proctological diseases it is made as a suppository and comprises 2-ethyl-6-methyl-3-oxypyridine succinate as an active component and a base chosen from group involving polyethylene oxide-1500, polyethylene oxide-400, cacao butter and hydrogenated fats. Invention provides prolonged release of a curative preparation in mucosa and soft tissues and provides its effect for about 12 h. The procedure is suitable and easy in performance and can be carried out by patients independently under ambulatory conditions.

EFFECT: valuable medicinal and pharmaceutical properties of agent.

3 cl, 2 tbl, 2 ex

FIELD: pharmaceutical industry, in particular agent for prophylaxis and treatment of rheumatoid arthritis and osteoarthritis.

SUBSTANCE: disclosed are suppository having mass of 2-2.5 g containing (g): diclofenac 0.0225-0.0525; glucosamine hydrochloride 0.175-0.525; lecithin 0.057-0.063; and balance: solid fat.

EFFECT: agent for prophylaxis and treatment of arthritis, degenerative joint and backbone diseases with increased anti-inflammatory action and reduced ulcerogenic action.

1 tbl, 3 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of a novel vegetable-base agent that can be used in treatment of inflammatory diseases of small pelvis organs and diseases of rectum. Agent used in prophylaxis and treatment of diseases of small pelvis organs and diseases of rectum comprises long turmeric (Curcuma longa L.) rhizome dried extract standardized by curcumin, anesthetic agent and pharmaceutically acceptable excipients. Agent is made as a suppository and comprises benzocaine as an anesthetic agent and vitepsol and cacao butter as a suppository base. Method for preparing agent used in prophylaxis and treatment of diseases of small pelvis organs and diseases of rectum involves mixing long turmeric dried extract standardized by curcumin with anesthetic agent and a pharmaceutically acceptable excipient. Method for prophylaxis and treatment of diseases of small pelvis organs and diseases of rectum involves using the proposed agent.

EFFECT: improved preparing agent, valuable medicinal properties of agent.

9 cl, 3 ex

FIELD: medicine, homeopathy, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates, in particular, to suppository possessing immunomodulating effect and comprising coneflower, accessory substances and a base, sea-buckthorn oil, arborvitae (thuja) homeopathic essence, baptisia homeopathic essence, Timalin-1C homeopathic trituratium wherein coneflower is a component of homeopathic essence. Suppository comprises anhydrous lanolin and wax as accessory substances and cacao butter as a base wherein components are taken in the definite ration in grams per one suppository of weight 2 g. Proposed suppository possesses the enhanced immunomodulating effect and allows stimulating processes of regeneration and hemogenesis and improves processes of cellular metabolism.

EFFECT: valuable medicinal properties of suppository.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: the present innovation deals with rectal suppositories that contain biphosphonic acids and their pharmacologically acceptable salts applied for preventing and treating diseases caused by affected calcium and magnesium balance in the body. The suggested new suppositories contain 0.1-10 weight% xydiphone and 0.5-10 weight emulsifiers, the rest - the foundation for one suppository of 1.125-2.5 g weight. Rectal xydiphone-containing suppositories could additionally contain medicinal and/or biologically active supplements, for example 0.1-1.0 weight% trisodium salt of phosphonoformic acid as medicinal additive, and, also, biologically active additive chosen out of the group of vitamin B6, B12 or carbon dioxide solution of common camomile, olive oil. The innovation provides the chance to avoid some complications occurred at applying this preparation in known forms and, also, in some cases leads to its increased efficiency.

EFFECT: higher efficiency of application.

4 cl, 4 ex, 1 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to an agent used in treatment of rheumatic arthrosis and osteoarthrosis. Proposed suppository comprises glucosamine hydrochloride, 0.475-0.525 g, and solid fat or mixture of polyethylene glycols of molecular mass 1500 and 400 Da (95:5), the balance, per one suppository of mass 2.0-2.5 g. Invention provides enhancing bioavailability of glucosamine and decreases the level of allergic reactions.

EFFECT: improved and enhanced medicinal properties of composition.

2 ex

FIELD: veterinary science.

SUBSTANCE: preparation for treatment and prophylaxis of endometritis in cows comprises antibacterial substance dioxydin, gelatin, glycerol and distilled water wherein food or medicinal gelatin is used as gelatin source, distilled glycerol if the 1-st grade is used glycerol source and comprises additionally resorcinol and veterinary algalipin in the following ratio of components, g: dioxydin, 0.1-0.3; resorcinol, 0.01-0.02; veterinary algalipin, 0.9-1.1; food or medicinal gelatin, 1.5-2.0; distilled glycerol of the 1-st grade, 5.0-5.4, and distilled water, 2.1-2.6. Invention provides enhancing effectiveness of the preparation and fertilization in cows.

EFFECT: improved and valuable veterinary properties of preparation.

3 tbl

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to creature of agents used in prophylaxis and treatment of diseases and pathological states associated with the locomotor system. Agent represents the complex preparation including the composition № 1 and № 2. The composition № 1 on hydrophobic base comprises the following active substances: phytocomponents of peppermint, common wormwood, mountain arnica, grape seeds, matricary, pine cones, pot-marigold, bur-marigold, sea-buckthorn oil, red pepper oil, red palm oil, mixture of essential oils of peppermint, lavender and clove in the ratio 1:1:1, bee venom, menthol, synthetic camphor and the following accessory substances: form-forming thickening agent - bee wax; preserving agent - propylparaben; emolents - cetiol CC, DC 345 and vaseline oil; antioxidant - kovi-ox. The composition № 2 on hydrophilic base comprises the following active substances: aqueous extracts of lilac flowers, mountain arnica, walnut peel; propocyanides of grape berries, propolis alcoholic extract, Kova-B-trox, and accessory substances: gel-forming agent - natrosol 250; moistening agents - propylene glycol and urea; chelating agent - disodium-EDTU; emolent - PLN phospholipids; preserving agents - methylparaben and caton CG; pH regulating component - triethanolamine and deionized water. Proposed agent possesses the expressed and prolonged curative effect that allows its using both for prophylaxis and treatment of different diseases and damages of structures in locomotor system and for improving skin state and adjacent tissues. Agent shows high therapeutic activity, namely its rapid and deep penetration into tissues, heating and relaxing effect, improving circulation in tissues and enlargement of blood vessels. Agent shows analgesic, anti-inflammatory, anti-edematous effect, accelerates reparative processes and improves tissue trophism. Agent shows the complex directivity on all mechanisms in base of diseases and pathological states of the locomotor system and their clinical symptoms and possesses the broad spectrum of pharmacological effect and both recovers the damaged functions of organ and shows the systemic effect on all body.

EFFECT: valuable medicinal properties of agent.

2 tbl

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