Method for enhancing of effectiveness of therapeutic or cosmetic agents with gold nanoparticles

FIELD: medicine, cosmetology.

SUBSTANCE: invention relates to enhancing of pharmacotherapeutic effectiveness of therapeutic or cosmetic agents representing disperse systems containing gold nanoparticles with size of 100 nm or less. Claimed agent is applied on skin region and then this region is exposed with magnetic field or electrophoresis.

EFFECT: increased therapeutic or cosmetic effect.

 

The invention relates to medicine, namely to cosmetology and therapy. The invention relates to methods of enhancing therapeutic and cosmetic qualities of the funds representing the dispersion system.

Additional therapeutic agents known drugs, containing particles of gold or its compounds. Descriptions of these tools can be found in the treatise "Jude-Shi".

Got more and more popular cosmetic products, made according to ancient recipes of the East, which contain gold [1]. It is known that gold can interact with proteases, gidrolizuemye collagen, as well as elastase and other active components of the connective tissue [4].

Gold has anti-inflammatory, immunodepressants, antitumor, antifermentny and some other therapeutic effects. Gold preparations used in the treatment of patients with rheumatoid and psoriatic arthritis, a syndrome still's, lupus erythematosus.

Particulate gold, used in cosmetics East, not able to penetrate through the epidermis. Their presence in cosmetics should be considered only as a factor of psychological impact on the consumer.

Actually, penetrating through the epidermis into the tissue may have ions and nanoparticles of metals size up to 100 nm.

Well-known cosmetic composition, in which the cancel powder gold with particle diameters of 0.3-0.9 μm (JP 9249516 from 22.09.1977). The disadvantage of this composition in the size of the gold particles that exceed a size of 100 nm.

Known cosmetic to improve the appearance of skin (JP 63068513 from 28.03.1988). The product contains nanoparticles with a diameter of from 0.01 μm to 20 μm, representing a mycelium-based termophotovoltaic of the silicone resin particles used as carriers of metal powder of gold, silver, tin, aluminum and the like pigments. Known means improves the color and luster of the skin, has the ability to delay the ultraviolet rays. The disadvantage of this is that it cannot be used to enhance biological processes due to the growth of the micelles over 100 nm in the process of cooking tools.

The task of combating ultraviolet radiation suggests that the nanoparticles should remain on the skin surface, without penetrating into the dermis. Here, the combination of improving skin appearance and quality possible.

The closest prototype is cosmetic with flakes of metal oxide (JP 2004339243 from 02.12.2004). The tool may include a number of oxides of: silicon oxide, titanium oxide, aluminum oxide, zirconium oxide and gold nanoparticles having a diameter of 1 to 300 nm. The purpose of the funds is to give a bright shade of skin.

Together with decorative properties is, known means can be used to influence biological processes in the skin, as contained in the nanoparticles, under certain conditions, can penetrate through the epidermis into the dermis. The disadvantage of this is that at the same time with the gold it contains other metal compounds. It is known that nanoparticles, in comparison with the particles, have a significant chemical activity. This may result in the formation of intermetallic compounds, which influence on the dermis has not been studied. In addition, for the introduction of nanoparticles in the dermal layer, it is necessary to use special methods of physiotherapy that is known for the invention is not developed.

The task of the invention is to provide a method for enhancing therapeutic efficacy gold health and beauty products, while their safety for the health of the consumer.

To solve the problem in medical and cosmetic, which is a disperse system ointment, cream, gel, liniment, etc. are invited to enter the gold nanoparticles. The particle size up to 100 nm.

The gold nanoparticles form in the dispersion medium of the electric double layer that is surrounded by its ions [2].

Thanks to the huge specific surface area of the nanoparticles, compared the Oia with the particles when they are equal to the total mass, the number of ions emitted by the nanoparticles, at least in the 104times this amount allocated by macroparticles. Despite the high chemical inertness of gold, the number of possible ions derived from the nanoparticles, it becomes important to use them even in cosmetics, where the total amount of heavy metals must not exceed 0.002 wt.% (GOST R-2005).

The proposed method is to obtain a disperse medium with a complex phase, which includes nanoparticles and their ions. This tool can be used for electrophoresis with the aim of introducing ions into the fabric. But in this case, particles epidermis remains a formidable obstacle. Own suction capacity of the skin is known to be quite limited, although they can, to some extent, to increase the known techniques: massage, ultrasound, electrical stimulation, magnetic therapy.

Because the gold nanoparticles are diamagnetically, it is proposed to influence them ponderomotive forces a constant magnetic field with a large gradient. As you know, the diamagnetic pushed out of the magnetic field ponderomotive forces [3], which distinguishes them from paramagnets and ferromagnets, which are attracted by magnets. The effectiveness of buoyancy depends not so much on EmOC is azenosti field, but on its gradient. That is, to achieve this goal possible the use of common permanent magnets or magnitofonov.

Although the described effect in physics known for a long time, practical application, he almost never got because of its specificity. In medicine and cosmetology analogues are not known.

To test the ability of the proposed method were fabricated samples of dispersed systems, representing gels based on hyaluronic acid. One version contained the gold nanoparticles with size up to 100 nm with a concentration of 10 mg/kg In another embodiment, the gold nanoparticles of the same size was a concentration of 200 mg/kg

Next, the tool, where the concentration of the nanoparticles was 200 mg/kg, was tested in 17 patients with rheumatoid arthritis on the knee joints. Every day they electrophoresis was performed on the lesion, where the active electrode (anode) area of 100 cm2applied vehicle; a current strength was 6-10 mA, duration 20 minutes After 10-15 procedures, the majority of patients had a reduction or elimination of pain. In 6 patients was observed lasting effect up to one month. And even in 3 - effect persisted for up to three months.

The test results allowed to conclude about the applicability of the tools in physiotherapy for the treatment of ARTRI the s.

The tool with the concentration of gold nanoparticles (10 mg/kg has been tested as a cosmetic. To this end 8 persons older than 45 years were offered daily during the week, apply evenly on the skin of the cheeks and then to massage a permanent magnet for 10 minutes on each cheek. Before treatment and after measurements were taken of the skin turgor. Upon completion of the course all patients noted a decrease in the depth and number of wrinkles, increased skin turgor.

The tool has shown its applicability as a cosmetic.

Because the use of ponderomotive forces of the magnetic field for influencing a diamagnetic nanoparticles in medicine and cosmetology were not previously offered, the invention meets the criterion of novelty. The level of its technology comes from the application of nanotechnology.

The applicability of the invention is proved by scientific research.

Properties diamagnetic have not only metals, but also many other substances. The present invention may be used for other medicinal and cosmetic substances, consisting of diamagnetic.

Sources of information

1. Artemova, A. Gold healing and rejuvenating. - M - SPb.: "Dilya", 203, str-94.

2. Simon A.D. Colloid chemistry. - M.: "AGAR", 2002, p.45-47.

3. D.V. sivukhin General physics course, VOL. - M.: "Nauka", 1977, str, with R.

4. Rocky V., Rudakov I.A. Bioelements in medicine. - M.: Mir, 2004, p.166.

The way to increase therapeutic efficacy of therapeutic or cosmetic products, which is a dispersive system, characterized in that the dispersion system make the gold nanoparticles, which have a size up to 100 nm, then the product is applied on the skin area, then this area is affected by a magnetic field or by electrophoresis.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves treating patient organism with magnetic field. The field is produced with device having ferrite-garnet having strip domain of 13-20 mcm wide. Scanning device movements are made over the lateral and frontal thoracic surfaces distantly, 5-35 mm far. Exposure time is equal to 3-6 min. The treatment course is 5 sessions long with 12 h long pauses.

EFFECT: reduced risk of complications.

3 cl

FIELD: medicine.

SUBSTANCE: method involves exposing injured zone and Zakharyin-Gedda zones to magnetic field action, generating by device having magnetic ferrite-garnet film having strip domain of 13-20 mcm wide.

EFFECT: accelerated treatment course; applied combined treatment with intensive care.

4 cl

FIELD: therapy.

SUBSTANCE: the apparatus has a magnetic body located in a freely moving member that itself is positioned inside the apparatus. The apparatus is actuated by an electric motor, which makes the freely moving member and the magnetic body rotate about the first axis of rotation. The magnetic body is rotated about the second axis of rotation by angular forces which act on it either mechanically or by means of a magnetic field. The mechanical angular force is transferred with the aid of a gear train or some other similar contact interaction with the rolling member. The magnetic angular force is transferred with the aid of fixed magnets, when the magnetic body passes by them at its rotation. Two rotary motions of the magnetic body occur at an angle to each other and result in variation in time both of the density of the magnetic flux and of the angle of flux turn.

EFFECT: enhanced quality of magnetic influence.

53 cl, 18 dwg

FIELD: medicine.

SUBSTANCE: the influence is effected by linear - and helical-shaped autowaves formed by a fixed source of a static magnetic field and premanent magnets moving on a rotating disk. The fixed source is installed at an angle of 90 deg. To the moving magnets, and having a magnetic screen with a hole. Generation of fields is accomplished at rotation of the disk. The influence is effected by an additional static magnetic field at angle 2ϕ=1800 to the patient's body in the same plane with the fixed source of magnetic field and the moving magnets, the patent's body is located between them. The influence is effected by an additional static magnetic field incoming from a double turned over tetrahedral pyramid made in the form of a narrow pyramid inside the wide pyramid, with flat permanent magnets installed outside on their walls between poles N for mutual repulsion. The patient's body is located between the rotating disk at angle 2ϕ=1800 and the pyramid at angle 2ϕ=1800 in the same plane. The influence is effected by a concentrated static magnetic field incoming from a tetrahedral truncated pyramid, with permanent magnets installed inside, and having an additional platform on top the pyramid, with flat permanent magnets installed on it with magnetic cores located at angle 2ϕ=1800 to the patient's body in the same plane with the moving magnets. The patient's body is between them. The linear-shaped autowaves are formed with the use of interacting sources of magnetic field for attraction an angle ϕ=900±20, 2ϕ=1800±20 of the helical-shaped auto wave, they are formed with the used of interacting of magnetic field source for repulsion at angle ϕ=900±20, or 2ϕ=1800±20 from permanent magnets with residual induction from 0.3T to 1.3T at a frequency of influence within 50 to 150 Hz, and a clockwise generation of magnetic fields is accomplished.

EFFECT: enhanced efficiency of influence by a magnetic field on the biological object.

4 cl, 11 ex, 9 dwg

The invention relates to medical equipment and can be used for treatment by pulsed rotating magnetic field on the biologically active points (BAP) man

The invention relates to medicine, ophthalmology

The invention relates to medical equipment and can be used for magnetic therapy, and to examine the effect of variable low frequency of vortex magnetic fields on biological objects

The invention relates to medicine, and is intended for the treatment of BPH

The invention relates to medicine, and is intended for the treatment of chronic hepatitis and liver cirrhosis

The invention relates to medicine and can be used for treatment of neuro-vascular pathologies

FIELD: medicine.

SUBSTANCE: method involves locally applying Wobenzyme powder aeroinonophoresis. The treatment course is 15 procedures long.

EFFECT: accelerated treatment course; improved microcirculation and tissue trophism conditions.

4 dwg

FIELD: medicine.

SUBSTANCE: method involves administering drug therapy with nitrates. Respiratory muscles are additionally exposed to transcutaneous AC electrostimulation with electrodes arranged posteriorly paravertebrally at the level of Th VII - Th XII and anteriorly between parasternal and clavicular median lines along 5-7 intercostal spaces. Stimulation is 20 min long and treatment course is 10 procedures long.

EFFECT: stimulated blood circulation in respiratory muscles and intracardial anastomoses.

1 tbl

FIELD: medicine.

SUBSTANCE: method involves making local 5% aminocaproic acid injection into periocular tissues in the amount of 1.0 ml. Then, bath electrophoresis is carried out 1-2 h later in hyphaema cases. Endonasal electrophoresis is applied in hemophthalm cases and eye fundus hemorrhages with proteolytic enzymes like 0.2% trypsin and chemotrypsin solution for 15-20 min with current intensity of 1.5 mA. Intravenous infusion of 100 ml of 0.03% sodium hypochlorate solution is carried out once or twice a day with the number of injections equal to 2-3 in hyphaema cases and 3-5 injections in hemophthalm and hemorrhages cases.

EFFECT: high accuracy of early stage diagnosis.

FIELD: medicine; sports medicine.

SUBSTANCE: muscles are subject to long-time low frequency electric stimulation; simultaneous extension of muscles is provided. Rectangular bipolar pulses 15 GHz frequency and 500 microseconds duration electrically stimulate muscles with.

EFFECT: higher stability of muscles at isokinetic mode; absence of reduction of maximal random power of stimulate muscles.

FIELD: medicine; electric engineering.

SUBSTANCE: method and device for generation of electric signal to be used in bio-medical applications has two time-presetting units 92, 94 for generation of time intervals T1-T7, unit 96 for combining mentioned intervals into output signal, which has predefined relation between intervals, output unit 104 for transmitting output signal to load, filter 102 for removing undesired frequency components and tuning unit 100 to select output signals from set of signals, which output signals have predetermined characteristics. Output signal has to be repeating sequence of rectangular pulse packages, equalizing impulse (if necessary) to eliminate constant shift in case when it is undesirable, and rest period with absent signal. In case when permanent shift is required, it is possible to neglect equalizing pulse. In this case the rest signal includes superimposed permanent potential.

EFFECT: widened area of application; wider area of application; higher rate of wound healing; better pain relief.

68 cl, 18 dwg, 2 tbl

FIELD: medicine; electric engineering.

SUBSTANCE: method and device for generation of electric signal to be used in bio-medical applications has two time-presetting units 92, 94 for generation of time intervals T1-T7, unit 96 for combining mentioned intervals into output signal, which has predefined relation between intervals, output unit 104 for transmitting output signal to load, filter 102 for removing undesired frequency components and tuning unit 100 to select output signals from set of signals, which output signals have predetermined characteristics. Output signal has to be repeating sequence of rectangular pulse packages, equalizing impulse (if necessary) to eliminate constant shift in case when it is undesirable, and rest period with absent signal. In case when permanent shift is required, it is possible to neglect equalizing pulse. In this case the rest signal includes superimposed permanent potential.

EFFECT: widened area of application; wider area of application; higher rate of wound healing; better pain relief.

68 cl, 18 dwg, 2 tbl

FIELD: medicine.

SUBSTANCE: method involves carrying out electroneurostimulation with neuroimpulse direct current applied to hands using outer electrode. Next to it, sensory zones of oral speech are acted within four-stage treatment comprising medical training exercises, mechanotherapy applied immediately after the training with domestic things being used and medical singing procedure. All medical exercises and exercises with domestic things are performed on the background of medical singing procedure keeping the same tempo as it is determined by selected song. The medical exercises and mechanotherapy with domestic things are done with paretic extremity. The medical exercises and mechanotherapy are carried out with the left hand if the patient is left-handed.

EFFECT: enhanced effectiveness of treatment.

2 cl, 3 tbl

FIELD: physiotherapy.

SUBSTANCE: method comprises sparing or sparing and training regimen of motion activity, special diet (number 5), oral administration of low-mineralized and low-carbonized calcium-sodium sulfate-hydrocarbonate mineral water and performance of low-carbonized calcium-sodium sulfate-hydrocarbonate mineral baths. Additionally, electrophoresis with 2% succinic acid solution is effected for 15-20 min on trigeminal nerve innervation region in the form of half-mask. Treatment of the left and right halves of the face are alternated. Treatment course comprises 12 procedures.

EFFECT: improved energetic exchange and adaptation processes.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: method involves taking measurements from biologically active points on classical meridians according to Nakatani method estimating first of all C, VB, IG, TR, GI, RP, V, F meridians state. Mental and speech development delay and background neurologic-and-behavioral disease elements are detected. Medical treatment is carried out via controlling biologically active points of the classical meridians. Wernike zone, Broca zone and initiative zone projections upon patient scalp are additionally included into cranial zones set. Selected cranial zones treatment is carried out via extrameridian biologically active points available in the center of mating brain area or zone projection. Meridian C hyperfunction points out to availability of residual perinatal brain cortex hypoxia phenomena. These cases are treated in mediated sedative operation mode. Meridian VB hyper- or hypofunction points out to brain cortex blood supply disorders as a result of brain blood vessels dystonia. These cases are treated in mediated sedative operation mode or mediated and direct stimulating mode, respectively. Meridian IG, TR, GI hypofunction points out to reduced endorphin system activity as a result of stress situation. The cases are treated in mediated and direct stimulating mode. Meridian RP and/or V hyper- or hypofunction points out to liquor dynamic disorders. These cases are treated in mediated sedative operation mode when hyperfunction takes place, and in mediated and direct stimulating mode in hypofunction cases, respectively. Meridian F hyperfunction points out to availability of subcortical structure disorders. These cases are treated in mediated sedative operation mode. The sedative treatment actions upon control and extrameridian biologically active points is carried out with DC of negative polarity, and stimulating treatment action is carried out current pulses of positive and negative polarity. Direct action applied to meridian in hypofunction state is applied to accomplice point, stimulating point and sympathetic point of the meridian. Mediated or direct stimulating treatment applied to meridian in hyper- or hypofunction state is applied to accomplice points, Luo-points, stimulating points, sympathetic point and connection points selected from P, MC, C, IG, TR, GI, RP, F, R, V, VB, E, VG, VC meridians according to classical acupuncture principles, taking these meridians state, determined by applying Nakatani method, into account. Wernike zone projection upon patient scalp is treated when dealing with disorders of comprehension and attention to addressed speech. Broca zone projection is treated when dealing with disorders in pronouncing words and phrases. Initiative zone is treated in reduced speech activity and hysteria phenomena cases. Corporal and auricular biologically active points are treated symtomatically. When applying sedative and stimulating treatment mode in controlling and extrameridian points, short-circuit current intensity is equal to 40-120 mcA. Positive and negative polarity pulses duration in stimulating treatment mode is equal to 2-6 s. Electrode contact area is selected equal to 0.2-12.0 mm2. Exposure time in each biologically active point is equal to 45-90 s. Treatment sessions are applied in everyday mode with single session being 40-60 min long and total treatment session number being equal to 13-18 per treatment course.

EFFECT: enhanced effectiveness of treatment.

6 cl

FIELD: medicine.

SUBSTANCE: method involves applying low-amplitude electric and/or magnetic stimulation without wakening patient. The stimulation treatment is carried out during slow wave phase of human nocturnal sleep at frequency belonging to 0.5-4 Hz bandwidth selected to be maximum close to patient delta-activity characteristic frequency. Continuous stimulation cycle duration is not less than 10 min repeated in all slow wave phase of sleep during night time. The total treatment course is not less than 10 nights long one after another. Positive dynamics being achieved, the treatment course is to be continued. No dynamic changes being observed, another stimulation is to be selected by changing electric stimulation for magnetic one or vice versa or for combined stimulation using electric and magnetic stimuli in turn during one night or during two following nights.

EFFECT: enhanced effectiveness of treatment.

FIELD: tooth-pastes.

SUBSTANCE: claimed tooth-paste has viscosity of less than 500 Pa.s at 0.1 s-1 and 25°C. Typical compositions include more than 2 w % of surfactants; more than 1.2 w.% of flavoring agent, more than 50 % of liquid carriers including controlled amounts of water and moistening agents or alternatively polyoxyethylene thickener.

EFFECT: paste of improved cleaning properties and flavor.

11 cl, 4 ex

Up!