Method for producing means for treating infected injuries
SUBSTANCE: method involves crushing shungit mineral to fraction size of 5-10 mm large and placing it into drinking water in 1:15-1:20 proportions by volume and keeping them together at room temperature 3 days long. The extract is saturated with colloid silver ions to concentration of 5000 mcg/l and 100% Volatile Australian tea tree oils are next added in the amount of 15-30% by volume.
EFFECT: accelerated wound healing including persistent ones.
2 cl, 2 dwg
The present invention relates to medicine and can be used in surgery for wound healing, including chronic, long nonhealing wounds, trophic ulcers, erysipelas, refractory to conventional treatment.
A method of obtaining funds "Argolic" for the treatment of infected wounds (see the description of the patent RU No. 2245151. Published 27.01.2005, bull. No. 3). This method is impregnated with finely ground zeolite with a solution of silver salts, followed by drying. The result is a powder of zeolite, which contains the external and internal surfaces of the particles of metallic silver. The treatment is carried out by application of a thin layer of the obtained powder on the wound.
Having non-specific action level during colonization processes of the cell, silver blocking of sulfhydryl groups of the enzyme systems of pathogenic microorganisms. In addition, interacting with the molecules of nucleic acids, silver leads to inhibition of growth and reproduction of microorganisms.
However, the impact of the modified silver zeolite to pathogens depends on the concentration of silver and the area of contact with the bacterial environment, as well as the application of a thin layer of powder on a large wound surface is not very convenient and time-consuming, require considerable is esta bandages.
Closest to the claimed is the method of obtaining funds for external use in treatment of skin and allergic diseases and inflammation of the mucous membranes of the oral cavity, including for the treatment of wounds (see the description of the patent RU No. 2074723. Published 10.03.1997, bull. No. 7). In the proposed method, the crushed mineral shungite fraction size 5-20 mm pour drinking water in the ratio 1:1 by volume, stand them together at room temperature for 2-3 days and then this extract is treated with the wound surface.
Mineral shungite - the oldest carbon-containing mineral having an unusual carbon matrix. The molecules of this carbon is similar to a soccer ball and are called fullerenes. Shungite carbon has high chemical activity in redox processes. ("The Karelian shungite and their integrated use", edited by Vasaryova and Ukkonen, Petrozavodsk, Karelia, 1975).
Prolonged contact of water with the mineral shungite leads to the structuring of water due to the action of the energy field of the mineral water. The resulting infusion of mineral salts (K, CA, Mn, S, Se and others) and organic compounds acquires special properties: actively destroys pathogens and promotes effective absorption chertkow contained components. Shungite water is biologically active and acts on the body multifaceted. It has analgesic, anti-inflammatory, antibacterial and antihistamine properties and does not cause side effects.
The disadvantages of the prototype are the duration of the healing process, the probability of secondary infectious complications.
The task of the invention is the creation of effective treatments, with higher antibacterial, anti-inflammatory, analgesic, anti-inflammatory and antihistamine properties.
The technical result is to reduce the time of healing of various infected wounds, including long-term, not reacting in a few months for treatment by known means, as well as in the exclusion of secondary infectious complications, which can reduce the time spent by the patient in hospital and, thereby, reduce the cost of treatment.
This is achieved by the known method of obtaining funds for the treatment of infected wounds, which consists in grinding the mineral shungite to the fraction size of 5-10 mm and placed in drinking water with extract them together at room temperature for 3 nights, the location of the mineral shungite in drinking water is carried out at a ratio of 1:15-1:20 by volume, and polucen the second infusion is poured and injected ions colloidal silver concentrations up to 5000 µg/l and then adding 15-30 vol.% essential oil of the Australian tea tree 100%. The location of the mineral shungite is carried out in a purified on THE 0131-002-29317930-05 drinking water.
Figure 1 shows the left lower leg of the patient (case 1) on the fifth day of therapy offered by the tool.
Figure 2 - left lower leg after a course of therapy.
In practice, for the treatment of infected wounds was obtained as follows:
Crushed mineral shungite of zazhoginsky deposits (Produced NPK "carbon-Shungite", , Petrozavodsk. THE 5714-007-12862296-01), size 5-10 mm fraction, pour purified drinking water ("Old-Mytishchi source" THAT 0131-002-29317930-05) in the ratio of 1:15-1:20 by volume and incubated together at room temperature for 3 days, then the infusion is poured and saturate it with ions colloidal silver concentrations up to 5000 µg/l by electrolysis using a silver electrode using a generator colloidal silver ion "George" (manufactured by JSC "Diode" THAT 3697-002-17664661-2002). To the resulting composition to add 15-30 vol.% essential oil of the Australian tea tree 100% (Pharmaceutical standard Australia AS 2782. Seller: Company "Art Life"). Before application of the composition are thoroughly mixed. Wounds treated with hydrogen peroxide and the proposed remedy. Bandaging wounds or ulcers is richly soaked in this solution napkins. In the following, wipes wetted Rast is a PR, not razbitaya wounds within 3-4 days.
Example 1: the Patient P., born in 1941 Complaints about pain in the left tibia. More than 15 years suffers from varicose veins of the lower extremities.
Objectively: the Patient came by herself. Leg bandaged. From the foot comes sweet and fetid odor. The front part of the leg and ankle of the left leg badly swollen, black, tibia covered with numerous black scabs. While the toes of normal color, warm, sensitivity saved, ripple weakened. Ripple in the popliteal fossae of both legs weakened. AD-140/80 mm Hg, PS 110 beats per minutes
Diagnosed with chronic venous insufficiency, varicose veins, cellulitis of the left lower leg, complicated starting with wet gangrene.
Assigned to: Treatment of leg 4-5 times a day with hydrogen peroxide, followed by imposition of napkins soaked proposed product containing 30 vol.% Australian tea tree 100%, during the day, napkins multiply abundantly watered by the proposed tool, not razbitaya wounds. Before processing the remedy for healing wounds thoroughly mixed by shaking.
By the end of 1 day of treatment, the patient has been abundant discharge of the contents of the two opened ulcers. Ulcers were treated with hydrogen peroxide and produced by ligation of RA is s throughout tibia napkins, abundantly moistened offered by the tool.
At day 2 on the inner surface of the shank formed 2 fistula. By the end of 2 days has been abundant discharge of the contents of the fistula.
After three days significantly decreased swelling of the legs. Changed color disappeared scabs, lost the scent.
On the 19th day select the contents of the fistula decreased. The skin bluish-pink color. Ripple in the popliteal fossa improved. After completing the course of therapy offered by the tool (2) is detachable from the remainder of the fistula stopped, the swelling is gone. It is recommended to repeat the course of treatment.
Example 2: the Patient M, 54 years old, diagnosed with relapsing form of boils, furuncles left femur, tibia.
After opening and cleaning wounds, the treatment with hydrogen peroxide solution with the subsequent imposition of wipes moistened with the proposed remedy, including 15% of the essential oil of the Australian tea tree 100%. Ligation was done 1 times in three days.
In the next 3 days, 5 times a day moistened wipes offer a means, not razbitaya wounds. After removal of the dressing over 4 days the wound is clean, there is an active granulation. They were re-imposition of napkins soaked with the proposed facility, with subsequent wetting 5 times a day. This technique was applied for 15 days, then came the call is Orellana.
Example 3: Patient N., 56 years old, diagnosed with diabetes mellitus type 2, subcompensated, chronic trophic ulcer of left tibia 3·3 see the Duration of the presence of ulcers - 3 months.
Conducted traditional methods of treatment using known antiseptics and multicomponent ointments did not lead to wound healing. Processing was carried out ulcers with a solution of hydrogen peroxide with the subsequent imposition of wipes moistened with the proposed tool, comprising 25% of the essential oil of the Australian tea tree 100%. Ligation was done 1 times in three days.
In the next 3 days, 5 times a day moistened wipes offer a means, not razbitaya. After removal of the dressing over 4 days shows that there is an active healing of ulcers. They were re-imposition of napkins soaked with the proposed facility, with subsequent wetting 5 times a day. This technique was applied for 18 days, then she recovered.
Example 4: A. Patient, the diagnosis of chronic venous insufficiency, varicose veins, cellulitis of the left tibia.
After dissection and treatment of wounds with hydrogen peroxide is conducted overlay wipes moistened with the proposed remedy, including 30% of the essential oil of the Australian tea tree 100%. Ligation was done 1 times in three days.
In the next 3 days 5 times a day moistened wipes pre the proposed tool, not razbitaya. After removal of the dressing over 4 days shows that there is an active healing of ulcers. They were re-imposition of napkins soaked with the proposed facility, with subsequent wetting 5 times a day. This technique was applied for 16 days, the healing came secondary tension without infection.
Example 5: the Patient P., 44,, diagnosed with erysipelas of the leg. On a background of antibacterial therapy patients received treatment of inflamed skin area of the proposed remedy. Recovery occurred after 15 days.
Examples of the use of the proposed tools in patients with various infected wounds testify to its positive influence on the course of the wound process in the presence of infection. Patients achieved complete wound healing without complications and recurrence of infection. It is logical to assume that promotes rapid healing "transport" the ability of tea tree oil, which contributes to the wound surface and through the skin of therapeutic components of shungite water, saturated colloidal silver ions.
Thus, the proposed method allows to obtain an effective remedy for the treatment of infected wounds, including long-term, do not respond within a few mesecina treatment known methods. It is relatively inexpensive, does not cause allergies, has no contraindications, it has high antibacterial, antifungal, anti-inflammatory, and sorption properties. The application of the proposed tool significantly reduces the risk of surgical intervention (Example 1). Reduced consumption of dressings, facilitated the work of the medical staff. The use of the proposed tools can simplify and reduce quantitatively manipulation in the wound, which is important for the patient and medical personnel. The patient has the opportunity, during the day, wet wipes offer a tool as in hospital and at home. The healing time of wounds correspond to physiological. Decreases during a patient's hospitalization, thereby reducing the cost of treatment reduced the total period of disability for this type of diseases.
1. The method of obtaining funds for the treatment of infected wounds, which consists in grinding the mineral shungite to the fraction size of 5-10 mm and placed in drinking water with extract them together at room temperature for 3 days, characterized in that the location of the mineral shungite is carried out in drinking water at a ratio of 1:15-1:20 by volume, and the resulting infusion is poured and injected ions colloidal silver to conc is of 5000 µg/l and then adding 15-30 vol.% essential oil of the Australian tea tree 100%.
2. The method according to claim 1, characterized in that the location of the mineral shungite is carried out in purified drinking water, for example, "Old-Mytishchi source.
FIELD: medicine, in particular wound-healing accelerating agents.
SUBSTANCE: claimed agent contains (g): magnesium nanoparticles 0.001-0.5; polyethylene glycol (PEG)-1500 20-40; glycerol 10; nipagin 0.1, water 5-15; PEG-400 up to 100. Such agent represents suspension of magnesium nanoparticles in solution of PEG, glycerol and water.
EFFECT: preparation having storage stability; high wound-healing effect and prolonged action.
SUBSTANCE: the present composition includes nonvolatile, a silicone, fluid substance in the mixture with finely divided silicon dioxide and antibacterial active substance. Pharmaceutically active substance is a nondecomposing one and manifests physical stability in the composition.
EFFECT: higher efficiency.
31 cl, 5 ex, 2 tbl
FIELD: cosmetic industry.
SUBSTANCE: it is necessary to carry out immobilization of native casein of goat milk at 50°C obtained as a result of flocculation onto methyl cellulose followed by introducing fucoidane hydrolyzate, silver nitrate and glycoproteins of mucus of animal origin at the ratio of components that provide the following ratios of cream's components, weight%: glycoproteins of mucus of animal origin 13.0-15.0; native casein of goat milk 30.0-35.0; methyl cellulose 30.0-35.0; silver nitrate 2.0-2.5; fucoidane hydrolyzate 15.0-22.5.
EFFECT: higher efficiency.
7 cl, 2 ex, 1 tbl
SUBSTANCE: method involves carrying out immobilization of protein on methylcellulose used as a high-molecular compound and modification of its surface. Goat native milk casein prepared by flocculation is immobilized on its surface at temperature 50°C. Then silver nitrate and fucoidan are added in the ratio of components providing the following ratio of components in the agent, wt.-%: goat native casein, 40-45; methylcellulose, 40-45; silver nitrate, 0.5-2.5, and fucoidan, 9.5-17.5. Invention provides expanding antibacterial and wound-healing agents.
EFFECT: improved preparing method of agent.
7 cl, 1 tbl, 3 ex
SUBSTANCE: method involves collecting blood plasma enriched in blood platelets, incubating it with heparin during 18-24 h at +4°-6°C, centrifuging it at 3500-4000 rpm at +4°-6°C and suspending the obtained precipitate in 50-70 ml of 7-7.5% sodium hydrocarbonate solution. The produced output product is frozen at -40-42°C and stored under these conditions.
EFFECT: high quality of preparation applicable for treating trophic ulcers, decubitus ulcers and other skin injury cases.
SUBSTANCE: method involves formation of cylinder consisting of carbonic acid "snow" with diameter 1.0 cm, not above, and applications by wound defect perimeter on border with health tissue are carried out. The exposition time is 5 s, not above. Cryoapplications are repeated in 7-10 days if necessary. Method provides reducing period for epithelium formation, to improve conditions for microcirculation and provide formation of normotrophic scars. Invention can be used in treatment of chronic wounds.
EFFECT: improved method of treatment.
3 tbl, 1 ex
FIELD: medicine, combustiology.
SUBSTANCE: invention relates to a method involving the complex antibacterial treatment of burn generalized infection using topical and parenteral effect with antiseptics and antibiotic in patients suffering from deep surface burns. Solution "Butol" is applied on wound at 1-3 days as water-drying dressing. For the following 4-10 days in each other day ointment "Butolol" is applied on wound and ointment "Butolan" is applied in the following period in surface burns up to complete epithelization and in deep burns after surgery - necrectomy and in preparing wounds for autodermoplastic. Ceftriaxone is administrated in the dose 2 g per a day simultaneously with the topical treatment from 1-st to 12-th day and galavite is administrated by intramuscular route in the dose 200 mg in the first day and in the dose 100 mg from the 2-d to 12-th day per 24 h. Method provides enhancing effectiveness of treatment of burn generalized infection and to reduce hospitalization period of patients.
EFFECT: improved method of treatment.
FIELD: chemical-pharmaceutical industry, medicine.
SUBSTANCE: invention relates to a pharmaceutical preparation comprising a lipophilic phase in the amount 1-10% by mass, mixture of a surface-active substance and an accessory surface-active substance wherein a surface-active substance is chosen from polyoxyethylene glycerol esters and fatty acids and polyoxyethylene sorbitan esters and fatty acids, and an accessory surface-active substance is chosen from poloxamers, block-copolymers of polyoxyethylene and polyoxypropylene in the amount 1-50% by mass, hydrophilic phase in the amount 40-80% by mass, and ciclosporin or its derivatives as an active component in the concentration 0.1-20% by mass. Proposed pharmaceutical preparation is made in colloidal formulation for topical using and designated for treatment and prophylaxis of skin pathological alterations, and/or skin adventitious, and/or mucous envelopes including mucous envelopes in digestive tract, urogenital ways and bronchial system, and/or conjunctives.
EFFECT: valuable medicinal properties of pharmaceutical preparation.
17 cl, 5 tbl, 11 dwg
SUBSTANCE: method involves administering autolymphocyte fraction with stem cells and applying it to ulcer surface as injections. Then, newly separated fraction is applied as injection or application on ulcer surface with 7-8 days long pauses. The injections are done beginning from points arranged along ulcer perimeter and then over its surface in chessboard order. When administering the fraction as application, it is spread allover the ulcer surface.
EFFECT: enhanced effectiveness of treatment; excluded fraction and stem cells rejection.
SUBSTANCE: method involves applying a gauze napkin on wound impregnated with ointment of the following composition, mas. p. p.: ecdysterone, 0.001-0.01 g; pot-marigold flowers 70% alcoholic tincture (1:10), 10.0 g; Saint-John's-wort perforated herb 40% alcoholic tincture (1:10), 10.0 g; polyethylene glycol (PEG)-1500, 50.0 g, and PEG-400, 30.0 g. Method provides stimulating tissues reparation, decreasing inflammation and analgesic effect. Invention can be used in treatment of suppurative wounds.
EFFECT: improved method of treatment.
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to medicinal agent effecting on the immune system. Medicinal preparation comprises 5-amino-2,3-dihydro-1,4-phthalzinedione lithium or potassium salt. Preparations possess the antitumor and antioxidant effect. The developed variants of the medicinal preparation distinct by duration and spectrum of effect and by pharmacokinetic indices and depending on their purity they can be used in oral and intramuscular administration and for other medicinal procedures.
EFFECT: valuable medicinal properties of preparation.
6 cl, 3 tbl, 4 dwg, 12 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes a liquid curative composition that is designated for removing out a patient from the critical state. Proposed liquid composition for treatment by intravenous administration contains insulin in the dose from 16 to 40 IU per 500 ml of water, from 10% to 20% of dextrose, water, from 0.6875 to 1.375 g of calcium gluconate and from 0.75 to 1.5 g of potassium chloride. Proposed composition can contain additionally vitamins, heparin, amino acids, lipids and other essential for life substances. Using the proposed liquid composition provides minimizing results of enhanced metabolism developing in body under stress and critical conditions.
EFFECT: valuable medicinal properties of composition.
17 cl, 19 tbl
FIELD: medicine, dermatology.
SUBSTANCE: invention relates to using nitrogen oxide-producing components used for manufacturing a medicinal agent used in treatment or prophylaxis of subnail infection. Components comprise nitrite and organic acid. Before using each of indicated components is placed separately of one another. Nitrite is chosen from alkaline metal nitrites and earth-alkaline metal nitrites. Acid is chosen from formic acid, malic acid, maleic acid, acetic acid, lactic acid, citric acid, benzoic acid, tartaric acid, salicylic acid, ascorbic acid and their mixtures. At applying of indicated components on infected nail formed nitrogen oxides are able to penetrate through nail in the therapeutically effective dose. The effectiveness treatment index is similar or better as compared with oral treatment method but it shows lesser limitations with respect to safety including hepatotoxicity, severe cutaneous responses and interactions with other drugs.
EFFECT: improved method of treatment.
33 cl, 13 dwg, 16 tbl, 15 ex
SUBSTANCE: method involves applying xanthanic pitch as active base in pharmaceutical composition possessing reepithelialization properties and optionally but not obligatory mixed with hyaluronic acid.
EFFECT: accelerated and improved process of new epithelium growth.
21 cl, 11 tbl
FIELD: medicine, chemical-pharmaceutical industry, chemical technology.
SUBSTANCE: invention relates to using biologically active derivatives of ajmaline possessing anti-arrhythmic effect. Method for synthesis of N4-propylajmalinium salts with carboxylic acids is carried out by neutralization of N4-propylajmalinium hydroxide with equivalent amount of carboxylic acid in homogenous phase. The end substance is isolated by distillation of solvent with the yield of salts 97-99%. Method provides preparing acetate, l-lactate, hydrooxalate, hydromalonate, hydrosuccinate, hydroglutarate, l-hydrotartrate, hydrocitrate, salicylate and p-aminobenzoate. Stable solution of N4-propylajmalinium hydromalonate in water for injection of a medicinal agent comprises sodium metabisulfite as antioxidant, 5-30 mg/ml of N4-propylajmalinium hydromalonate, ascorbic acid as antioxidant taken in the effective amounts. Preferably, stable solution of N4-propylajmalinium hydromalonate comprises 10 mg of N4-propylajmalinium hydromalonate/ml of solution, 0.20 wt.-% of sodium metabisulfite and 0.05 wt.-% of ascorbic acid as measured for solution of N4-propylajmalinium hydromalonate. Invention provides the development stable aqueous compositions of N4-propylajmalinium salts for injection of medicinal agent by selection of antioxidants.
EFFECT: improved preparing method.
7 cl, 5 tbl, 5 ex
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention proposes a preparation used in healing wounds and for prevention sticking a bandage to wound. The preparation comprises hyaluronic acid sodium or potassium salt of molecular mass from 200000 to 2500000 Da, iodine, potassium iodide and water. The preparation is made in form of sterile aqueous solution or gel. The preparation possesses high effectiveness in infected and chronic wounds.
EFFECT: enhanced effectiveness of preparation.
4 cl, 16 dwg, 11 ex
FIELD: medicine, pharmacy, medicinal agents.
SUBSTANCE: invention relates to aripiprazol pharmaceutical solutions used in oral using and designated for treatment of schizophrenia. Proposed agent comprises aripiprazol, pharmaceutically useful system of solvents, one or more taste-improving/masking agents and one or more acids chosen from group consisting of lactic, acetic, tartaric and citric acid and wherein pH of proposed pharmaceutical solution is from 2.5 to 4.5. Invention provides dissolving difficultly soluble medicinal agent and to compensate aripiprazol bitter taste and to obtain stable solution of this substance.
EFFECT: improved properties of agent.
17 cl, 2 tbl, 3 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention describes hydrophilic and hydrophobic compositions used in treatment of infectious or viral diseases and a method for treatment. Hydrophilic composition comprises polynitro-compound of the formula: R-(NO2)n wherein n ≥ 2, dimethylsulfoxide and ethyl alcohol wherein the composition comprises dinitrotoluene and/or tetranitrotoluene, and pentanitrotoluene or mixture of at least one of them with trinitrotoluene as polynitro-compound of the formula R-(NO2)n. Hydrophobic composition comprises polynitro-compound of the formula: R-(NO2)n wherein n ≥ 2 and vegetable and/or animal fat wherein dinitrotoluene and/or tetranitrotoluene, and/or pentanitrotoluene or mixture of at least one of them with trinitrotoluene is used as polynitro-compound of the formula R-(NO2)n. Proposed compositions relate to lipotropic substances that are able to penetrate into tissues rapidly and blood and contact with pathogenic microflora actively.
EFFECT: valuable medicinal properties of compositions.
4 cl, 2 tbl, 10 ex
SUBSTANCE: invention relates to an enterally administrated supplement used for retention or recovery intestinal barrier in critically ill patients or chronic patients and in patients with deficient nutrition. Supplement contains the following components as a solution and measured for a daily dose, respectively: (a) glutamine and/or glutamine precursor taken in the amount from 15 g to 70 g; (b) at least two representatives from group of substances acting as antioxidants taken in the amount, and (c) saturated acids with short chain and/or saturated acid precursors in the amount 0.5-10 g. Invention provides enhancing retention or recovery of intestine barrier function.
EFFECT: valuable medicinal properties of supplement.
24 cl, 1 tbl, 3 ex
SUBSTANCE: liquid preparation forms of improved light resistance contain aqueous Sitafloxacin and sodium chloride solution.
EFFECT: wide range of functional applications.
22 cl, 2 tbl
FIELD: pharmaceutical industry, in particular production of therapeutic creams for preventing and treatment of dermatological diseases.
SUBSTANCE: claimed cream for psoriasis prophylaxis and treatment contains kilwort, bur beggar-ticks, and medical petrolatum; additionally it contains horse sorrel root, egg albumen, flower bee honey, and lecithin. All component are used in specific component ratio. Cream of present invention make it possible not only to effect on plaque eruption foci, but prevent of new eruption foci formation.
EFFECT: new effective cream for psoriasis prophylaxis and treatment.