Stockings or panty-hose with cosmetic and rejuvenating action, impregnated with slow-release natural substances, and method for producing the same

FIELD: textile base contacting with skin and adapted for producing of cosmetic and rejuvenating effect.

SUBSTANCE: method involves producing stockings, panty-hose or any textile base contacting directly with skin and impregnated with slow-release natural substances by providing following steps: coloring said textile base; treating for imparting softness thereto by introducing combination of biomimetic phospholipids into common bath-tab, said combination including phospholipids GLA-borageamidopropyl PG-dimoniumchloride sodium phosphate in an amount constituting 1.5% of bath volume, phospholipids PCT - cocoamidopropyl PG-dimonium chloride phosphate in an amount constituting 1.5% of bath volume, said combination of phospholipids components facilitating in "attachment" of or impregnation with active substances through electrostatic process and being also antibacterial agent facilitating in regulation of bacterial flora; adding natural active substances to said two phospholipids components, with total amount of natural active substances constituting less than 2.10% of bath volume. Said step of imparting softness or impregnation step is carried out during about 35 min at temperature of from 35 C to 37 C. Natural active substances are found in algae extracts or iris family extracts.

EFFECT: enhanced cosmetic and rejuvenating effect.

8 cl, 1 dwg, 1 ex

 

The object of the invention are stockings or tights, or any textile base, which is in direct contact with the skin with cosmetic or anti-aging action, impregnated with natural substances slow release, and the method of their production.

According to the invention, natural substances or active substances are kept in accordance with the method of implementation in extracts of algae and chastikovyh.

Algae extracts provide the skin tissue with oxygen and increase skin elasticity.

Extracts chastikovyh are a source of zinc and vitamin A. Zinc as a coenzyme involved in enzymatic reactions in the process of cell growth and regeneration of damaged tissues, activating the process of scarring.

Vitamin a is one of the main agents of cell growth through cell multiplication.

Algae extracts and chastikovyh have a synergistic effect, contributing antiradical activity.

Algae extract is obtained from Ulva lactuca. Extracts of this Alga have protective properties and increase skin elasticity.

The subject of the invention is also a method of production that allows you to impregnate stockings or tights or any textile basis having direct contact with skin, natural substances slow release.

The production method is that after the stage of painting in the process of imparting softness (flexibility) is injected into a regular bath, which impart softness (flexibility), biomimetic phospholipids.

Use the following combination of biomimetic phospholipids:

A) a phospholipid GLA (bargainedfor PG-Demonologist sodium), constituting 0.5% of the baths;

B) a phospholipid PCT (cocoamidopropyl PG-Demonologist), which is about 1.5% of a bath.

This combination of phospholipid components, first, helps "fixing" or impregnation of active substances electrostatic method and, secondly, is an antibacterial agent that regulates bacterial flora.

In addition to these two phospholipid components, introducing natural active ingredients, the total quantity of which is not more than 2,10%. Stage impart elasticity and impregnation lasts approximately 35 minutes at a temperature of from 35 to 37°C.

The amount of solution that gives elasticity, including phospholipid components of the active substance, must be in the ratio of 10 to 1, i.e. in the tub 10 kg of a solution circulates 1 kg of tights.

In accordance with the preferred method of implementation, use the following active substances or natural substances:

A) algae - max from 0.7 to 1.00%;

C) Ulva lactuca - Mac is imum from 0.3 to 0.5%;

(C) Iris Florentina - max from 0.3 to 0.5%;

D) Perfume 0.1 Percent.

The maximum total amount is 2.1%.

In accordance with another way of making use of the following active substances:

A) Panax - maximum of 0.25 to 0.35%;

B) Ginkgo biloba - a maximum of 0.25 to 0.35%;

(C) Metalistic - maximum of 0.25 to 0.35%;

D) Green tea - a maximum of 0.25 to 0.35%;

E) Aloe (Aloe Vera) - a maximum of from 0.50 to 0.70%.

The maximum total number of 2.10%.

Properties of extracts of algae and plants and their role in creating a new generation of tights or any textile fundamentals that have direct contact with the skin.

The invention relates to properties of tights or any textile fundamentals that have direct contact with the skin, allowing the use of substances contained in extracts of algae and chastikovyh, which in normal use are released upon contact with the skin.

Such stockings or tights, or any textile base, having direct contact with the skin, have a calming, eliminating a rush of blood, moisturizing, and especially anti-aging cosmetic effect, and these properties are obtained by use of the substances contained in the seaweed extracts and chastikovyh. They have also efficiency, synergy of these substances, used alone or combined in the other ingredients, as well as components that are suitable for their way of production.

Algae belong to the group of chlorophyll Tallarico, i.e. to a large family tenebrionid plants or plants without flowers, which are usually classified according to the color: green algae (chlorophycées), brown (pheophycées), red (rhodophycées) and blue (cyanophycées).

Rich in vitamins, mineral salts, antioxidants, able to bind and promote the excretion of harmful substances they stimulate the metabolism because they contained iodine. They contribute to the improvement of the General appearance.

In industry and agriculture algae used in various forms. In addition, they are used as nutrients in the treatment of some diseases associated with malnutrition and/or impaired metabolism. Due to their high iodine content of some brown algae (laminaria and focusy) used already in the XVII century in the treatment of goiter and graves ' disease.

Due to the fact that algae have different physiological effects, they are shown in such diseases and syndromes, such as:

- violation of iodine metabolism,

- organic failure,

- lack of vitamins and oligo-elements,

- rickets, obesity,

- tendency to rheumatism, atheroscle the RAM, various infections,

intestinal parasitosis,

some disorders of the urinary tract

- gastritis, colitis,

- circulatory disorders.

In addition to the nutritional properties of the algae, they are also used for cosmetic care, in particular thanks to its soothing, softening and cleansing properties.

Below are some commonly used algae and the effect they have:

Name: Ulva lactuca, or sea lettuce.

Origin: Mediterranean sea.

Main ingredients and indications: vitamin a, for protecting the skin and treating acne.

Name: Fucus or laminaria fucus.

Origin: the Atlantic coast.

Main ingredients and indications for use: the minerals, especially iodine (boosts metabolism), alginates (moisturizing effect, for external use), proteins, beta carotene, vitamins E (anti-aging effect), use in systems for weight loss to combat unsightly appearance of cellulite, creams and masks that prevent aging of the skin.

Name: Kelp (brown algae).

Origin: Norway.

Main ingredients and indications: calcium, potassium, vitamins, minerals and herbal mucus to moisten the local application, as well as in the system for weight loss.

Nae is the W: kelp or Kombu.

Origin: Japan.

Main ingredients and indications for use: the minerals, iodine, calcium and magnesium to eliminate toxins, reduce skin rashes and slow the aging process of the skin.

Name: Wakame.

Origin: Japan.

Main ingredients and indications for use: magnesium, iron, calcium and vitamins a, b, C to optimize the condition of the skin and skin appendages: hair and nails.

Name: Arame.

Origin: Japan.

Main ingredients and indications for use: iodine and calcium, which are used in systems for slimming and facial.

Name: Nori.

Origin: Korea.

Main ingredients and indications for use: proteins, beta carotene and iodine, giving the skin elasticity and freshness.

Name: Dulce.

Origin: Northern Europe.

Main ingredients and indications: iron and iodine, are used in systems for weight loss.

Name: Spirulina.

Origin: China, pools with soft water with chlorophyll and vitamins.

Main ingredients and indications for use: does not contain iodine, is used for detoxification and cleansing of the body, gives freshness to the skin, used in systems for weight loss.

Name: Klamath.

Origin: lake in Oregon (USA).

Main ingredients and indications for use: linakis is the notes and proteins, enzymes, chlorophyll, beta carotene, mineral salts, is used in systems for weight loss, slows down skin aging.

Name: Dunalielle salina.

Origin: North America, Australia and the Dead sea.

Main ingredients and indications for use: the highest concentration of beta carotene, is used as geroprotector, anti-aging, maintains the health and youthfulness of the skin has a protective effect in the media deck.

Name: Chlorelle.

Origin: Japan.

Main ingredients and indications for use: proteins, chlorophyll, vitamins and minerals, promotes elimination and regeneration of cells, is used in systems for weight loss to restore balance in the body and compensate for a possible lack of power.

Algae are increasingly used in cosmetics. The source of their dermatological properties are the active substances of which include: vitamins, antioxidants, such as vitamin a and D and vitamin C; specific moisturizing and mucous biopolymers; various secondary biologically active metabolite.

To currently used cosmetic products containing seaweed include: cleansing milk, toner, moisturizer, deodorant, hand cream, for face and for body, means for intimate guy who yen shampoo and special bath products, drugs against cellulite, scars, acne, improving the appearance of skin.

When cellulite treatment method thalassotherapy use sea water, rich in typical oligo-elements in combination with various types of algae. The treatment can be carried out using special cosmetic preparations, and may then be used for local application of drugs on the basis of algae as such or in the form of extracts, such as dirt, masks or other drugs made directly to the local application.

The lack of cosmetic products currently used, is associated with duration of use and time-limited contact with the skin during the day.

More specifically, the invention lies in the fact that the textile Foundation, have direct contact with the skin, such as stockings or tights, impregnated with active substances.

Stockings and tights, or any textile base, having direct contact with the skin, are the ideal basis for renewal of the cosmetic effect of the proposed products based on algae and chastikovyh, because they are constantly in contact with skin and provide beneficial effects of the active substances by their long and gradual release. It is I who is the innovation in this field.

Indeed, the use of substances obtained from various species of algae and chastikovyh, which are absorbed and are on the surface and inside of the textile fiber, which is made from stockings or tights, or any other textile base, having direct contact with the skin.

Of particular interest is the use of certain types of algae, for example:

Brown algae: Fucus, Pelvetia, Ascophyllum, Himanthalia, Laminaria, Sagrassum species.

Red algae: Chondrus, Mastocarpus or Gigantina, Palmaria, Prophyra, Ceramium and Gracilaria.

Green algae: Ulva, Enteromorpha and Codium.

One should mention also the following types of algae Ascophyllum nodosum, Pelvetia canaliculata, Enteromorpha, Palmaria palmata, Sagrassum muticum, Ceramium rubrum, Gracilaria verrucosa, Ulva lactuca, Laminaria digitata, Codium.

All algae have antiradical properties and properties directed against aging. Especially brown algae, which should be called Fucus vesiculosa.

In accordance with the preferred embodiment choose Alga Ulva lactuca, which contains the same amount of vitamin A, as in cabbage, and C as in oranges, and a wider range of vitamins C. have a high content of mineral salts and oligo-elements: iodine, bromine; CA, Mg and K; Mn, the presence of which can be explained by their protivoalergicescoe action.

Ulva lactuca contains the greatest number of amino acid is t (Proline, glycine and lysine), which are important for maintaining skin elasticity.

Table 1 lists the full composition of Ulva lactuca.

Table 1

Composition (average numbers) Ulva lactuca
THE. Lipids1,900
THE. Hydrates of carbon/fiber52,000
THE. Proteins21,000
THE. Minerals24,000
MineralsVitamins
Iron80Vitamin a960 IU
Calcium3,000Vitamin B10,06
Magnesium2,800Vitamin B20,03
Zinc5Vitamin PP2,6
Iodine10Vitamin B6*
Sodium3,400Vitamin B90,01
Phosphorus240Vitamin B120,01
Potassium5,000Vitamin C10
Manganese35 Amino acids
Copper3,6Phenylalanine780
Bor1,8Isoleucine740
Nickel2Leucine1,250
Chrome1,25Lysine700
Cobalt0,15Threonine700
Molybdenum0,2Tryptophan320
Tin0,01Valine1,200
Sulfur6,500Methionine280

Algae extracts used in the present invention, receives the traditional methods of extraction in the liquid phase, including use of fluids in the supercritical state.

As for extraction in the aquatic environment, it is performed with pH controlled using a special buffer solutions. Extraction is also carried out by use of polar solvents that are used or together, or in combination with an aqueous medium.

The final stages of the method of obtaining is dehydration of the extract by concentration in vacuum or reverse osmosis or concentration and purification by chromatography method or ultram is litraly. In these cases some separate substance from seaweed extracts obtained by chemical synthesis, such as fucoli, polyfocal, diflorasone, bifwoli, politally and floreali, which possess remarkable anti-radical action. Therefore, in the present description, the term "algae" is used generally to describe substances isolated from these extracts or obtained by chemical synthesis.

To impart a cosmetic effect stockings and tights or any textile fabric having direct contact with the skin, extracts of algae used in combination with extracts chastikovyh.

From chastikovyh is preferred Florentine variety Iris germanique, rich in polyphenols, flavanoids and anthocyanins that have high antioxidant activity and, therefore, a significant antioxidant effect. In order to make the devices, which is the object of the invention, properties, anti-ageing substances contained in extracts of algae, used in combination with one or more antioxidants.

Antioxidants, without limitation, reasonable for the purposes of the present invention are contained in the seeds, leaves, and peel fruits and plants and can be extracted from natural sources or be their sintet the economic equivalents.

Typical antioxidants include some amino acids (e.g. histidine and valine), flavonoids (e.g., aromadendrin, Maureen, quercitrin, hesperetin, naringenin, kaempferol, apigenin, luteolin, fisetin, Tustin, rutin, myricetin), anthocyanins (e.g., pelargonidin, cyanidin, delphinidin), catechins (e.g., catechin, epicatechin, gallocatechin, proanthocyanidin), carotenoids and retinoids (isomers of carotene, lycopene, xanthine, retinol, kataxenna), Tocopherols (e.g., alpha-, beta - and gamma-tocopherol), tannins (e.g., Gallic acid, esters propylgallate and Gallic acid, tannic acid), phospholipids (such as lecithin contained in the egg and soy), L-ascorbic acid and its esters, alpha-hydroxy acids (e.g. lactic acid, citric acid, L-tartaric acid), polyketide Monascus red, substances contained in peanuts and rice (for example, cardanol, cardol, Nakagawa acid, oryzanol, a little mahogany), thiodipropionic acid and the ester of lauric acid (DLTBP), alpha-lipoic acid, nordihydroguaiaretic acid (NDGA), guaiacol, hydroxytyrosol and esters of olive oil (for example, oleuropein, verbascoside), other phenols of spices and herbs (such as rosemary, allspice, cloves, pepper, cinnamon, ginger, paprika (TBHQ), citrus oils, trihydroxybutane (TNWR, BHT and BHA), maclurin, e is oxacin, ellagic acid, Mussin, Boldin, and their respective glycosides, esters and ethers, and combinations thereof.

Of the most preferred antioxidants should be called Gallic acid and its derivatives, ascorbic acid and its derivatives, and flavonoids contained in plant extracts or in purified form.

In addition, in the present invention using other types of active ingredients with complementary and/or synergistic effect.

As examples, without purpose restrictions specified categories, the following compounds having activity against wrinkles and anti-inflammatory action.

Of the substances having an anti-inflammatory effect, can be called licorice derivatives, flavonoids, alpha-bisabolol, rosemary, azulene, asiaticoside, ruscogenin, escin, Betulinol acid and its derivatives.

Examples of substances with activity against wrinkles, are retinol, tocopherol, salicylates and derivatives thereof.

For the production of tights or any textile fundamentals that have direct contact with the skin, which is the object of the present invention, it is possible to apply some of these methods.

Bond using polymer gels or resins containing active substances (algae and synergistic substances), the imposition of microcapsules, impregnation,precipitation or surface adsorption, for example, using appropriate surfactants.

Expedient is the use of cationic, non-ionic, anionic, amphoteric surfactants, and combinations thereof.

Of the surfactants should be called:

Non-ionic: alkoxylated alcohol and a fatty acid or sorbitan, polyoxypropylene and polyoxyethylene, alkylpolyglycoside.

Anionic: Soaps, fatty acids, sodium lauryl sulfate or lauryl simple ether, alkylbenzenesulfonate, mono - and/or dialkylphosphate and the like.

Amphoteric: oxides dialkylamino, different types of betaines, natural phospholipids and ceramides.

From surfactants are preferred biomimetic phospholipids (products Mona, USA), substance glycerophosphocholine origin with a cationic charge.

In addition, the device which is the object of the invention is treated with substances having an antiproliferative effect on various types of microorganisms, such as external alkilani p-hydroxybenzoic acid, hydantoines, paraben, imidazolidinethione, dehydroacetate sodium, benzyl alcohol and a number of components Quaternary ammonium, in addition, inorganic or mixed substances, such as components, treated with iodine or RT the flesh.

In the bath at the stage of imparting softness and the active substance can be entered solar filters, for example derivatives RAV, benzophenone and cinnamate in quantity, which depends on the desired degree of protection from ultraviolet radiation.

An example of a typology of stockings and tights and a composition comprising Ulva lactuca, extracts of green algae and extracts of Iris Florentina.

The attached drawing given by way of example and not limiting the invention. It shows only one way of carrying out the invention, which makes it easy to understand.

The drawing shows a schematic view of the system, allowing to fasten or to impregnate stockings or tights or any textile basis having direct contact with the skin.

This figure into the tank 1 receives phospholipids (phospholipid GLA (bargainedfor PG-diammoniumphosphate sodium) and phospholipid RTS (cocoamidopropyl PG-diammoniumphosphate), active substances and substances which impart elasticity, it is connected by a pipe 2 with a capacity of 3, having a larger volume, which is the capacity to effect the bonding or impregnation and in which there are stockings or tights, or any textile base, having direct contact with the skin 4. 5 mesh closes above the specified capacity 3. Pipe 6 connects the tank 3 to tank 1. Thus, the system is zamknutoi and provides a steady stream.

Position labels

1. Capacity

2. Pipe

3. The capacity for the operation of bonding or impregnation

4. Stockings or tights, or any textile base, having direct contact with the skin

5. Mesh

6. Pipe

Example

10 l of a solution containing water, RTS, GLA, active substances, take 9,59 l of water, and 0.15 RTS (1,5%), 0,05 GLA (0,5%), 0,10 Algue Marine (1%), 0,05 Iris Florentina (0,5%), 0,05 Ulva lactua (0,5%), 0.01 odorants (0,1%). 10 kg of this solution was placed 1 kg of tights. The active substance is impregnated textile fibers by cationic. This is done using a biomimetic phospholipids. When the fibers are impregnated with active substances (Iris Florentina, Ulva lactua, Algue Marine, perfume), GLA and RTS begin to improve fixation (binding) of active substances in the floor of their fibers, thereby making the active substance (linking) in the fiber.

Phase impregnation lasts 35 minutes. The time required for fiber exchanged active substances and GLA and RTS at a temperature of 35, 37°C. This temperature is selected depending on the temperature of the human body. GLA and RTS condition at this temperature of about 35, 37°so that these substances were reactive upon contact of the fiber with the skin. In other words, when the fiber reaches a temperature of 35°which is created by the human body, RTS and GLA become active and begin to release of the active substances is TBA, which they were made, and these active substances, in turn, begin to be released directly to diffuse into the skin throughout the day or period of wearing tights. Algue Marine, Ulva lactua, Florentine Iris, which slowly diffuse into the skin, stimulating cellular activity and increase hydration of the skin.

1. Method for the production of stockings, tights or any textile fundamentals that have direct contact with the skin, soaked with natural substances slow release, characterized in that after the stage of painting in the process of imparting softness in a regular bath, which impart softness, enter a combination of biomimetic phospholipids, including

the phospholipid GLA-bargainedfor PG-Demonologist sodium in number, constituting 0.5% of the bath,

the phospholipid PCT-cocoamidopropyl PG-Demonologist in number, which is about 1.5% baths, and

the combination of phospholipid components, first, helps "fixing" or impregnation of active substances electrostatic method and, secondly, is an antibacterial agent that regulates bacterial flora,

these two phospholipid components add natural active ingredients, the total quantity of which is not more than 2,10% from the bath, and stage giving m is Gasti and impregnation lasts approximately 35 minutes at a temperature of from 35 to 37° With natural active substances are contained in extracts of algae and chastikovyh.

2. The method according to claim 1, characterized in that the ratio of the quantity of solution, giving softness, including phospholipid components of the active substance, and textile foundations should be 10 to 1, 10 kg of a solution in the bath should circulate 1 kg of tights or any textile fundamentals that have direct contact with the skin.

3. The method according to claim 1, wherein using the following natural active ingredients:

seaweed - a maximum of from 0.7 to 1.00%,

Uva Lactica - max from 0.3 to 0.5%,

Iris Florentina - max from 0.3 to 0.5%,

perfume of 0.1%,

the maximum total number of which is 2.1%.

4. The method according to claim 1, characterized in that use the following active substances:

Panax - maximum of 0.25 to 0.35%,

Ginkgo biloba - a maximum of 0.25 to 0.35%,

Metalistic - maximum of 0.25 to 0.35%,

Green tea - a maximum of 0.25 to 0.35%,

Aloe (Aloe Vera) - a maximum of from 0.50 to 0.70%,

the maximum total number of which is 2,10%.

5. The method according to claim 1, characterized in that at the stage of softening of the bath containing the active substance, introducing solar filters in quantity, which depends on the desired degree of protection from ultraviolet radiation.

6. Stockings,tights or any textile base, having direct contact with the skin with cosmetic properties and properties against aging, impregnated with natural substances slow release, characterized in that they receive according to any one of claims 1 to 4.

7. Stockings, tights or any textile base according to claim 6, wherein the algae extract is obtained from Ulva lacluca.

8. Stockings, tights or any textile base according to claim 6, characterized in that chastikovyh preferably used Florentine variety Iris germanique, rich in polyphenols, flavanoids and anthocyanins that have high antioxidant activity and, therefore, a significant antioxidant effect.



 

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2 cl, 15 ex

FIELD: cosmetics, medicine, pharmacy.

SUBSTANCE: invention relates to compositions used in topical applying and possessing improved water-retaining properties and improved releasing of active agent. Proposed cosmetic compositions contain from 5% to 70% of pentane-1,5-diol by mass and cosmetically acceptable carrier and under condition that this composition doesn't contain polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, pantenol, pyruvic acid, lauric acid monoglyceride or myristic acid monoglyceride. Also, invention discloses corresponding methods for administration, plaster for attachment of indicated composition to skin and methods for prophylaxis or treatment of skin dryness state or maintaining skin in moisture state. Compositions for topical using and administration of pharmaceutical preparation possess the improved water-retaining properties, improved releasing active agent being without toxicity and skin irritation.

EFFECT: improved and valuable medicinal properties of compositions.

37 cl, 5 tbl, 1 dwg, 6 ex

FIELD: medicine, cosmetics, pharmacy.

SUBSTANCE: composition comprises hyaluronic acid sodium salt, aristoflex and polyphenol-containing vegetable extracts chosen from group including tannins and/or flavonoids. Composition can comprise grape kernel oil or tea tree oil additionally. Composition provides enhancing effectiveness of regenerating, anti-inflammatory and cleansing effect and possesses antioxidant, antibacterial and antiparasitic capacity. Invention can be used as composition used for face and eyelids skin care, among them, using microcurrent and ultrasonic therapy and for prophylaxis and treatment of blepharitis and demodecosis.

EFFECT: valuable medicinal and cosmetic properties of composition.

3 cl, 5 ex

FIELD: cosmetic industry, in particular deodorant and/or antiperspirant composition.

SUBSTANCE: stable deodorant and/or antiperspirant composition represents suspension essentially free from residue. Said composition is obtained by incorporation of a) cross-linked polymer, cyclomethycone (and) dimethycone from polysiloxane, containing group and α,ω-diene of formula CH2=CH(CH2)хCH=CH2, wherein cross-linked polymer has viscosity from 5000 to 3000000 cPs, and cyclomethycone contains preferably 8-18 % of non-volatile substances; b) polyethylene beads with density of 0.91-0.98 g/cm3 and particle size of 5-40 mum; c) volatile silicone; d) softening agent (or mixture of two or more softening agents) which may include non-volatile silicone and additional amount of volatile silicone; and e) effective substance with antiperspirant activity in amount sufficient to provide deodorant and/or antiperspirant composition activity. Composition of present invention reduces body perspiration by at least 40 %, essentially free from white residue.

EFFECT: deodorant and/or antiperspirant composition of improved efficiency and stability.

10 cl, 5 tbl, 24 ex

FIELD: medicine.

SUBSTANCE: product is suspension having a) composition based on cross-linked polymer of dimethycon/vinyldimethycon produced by polymethyl hydrosiloxane interaction with alpha, omega-divinyl polydimethylsiloxane in which the composition based on cross-linked polymer of dimethycon/vinyldimethycon is applied in concentration of 0.5-10% in cyclomethycon; b) polyethylene granules which density belongs to 0.91-0.98 g/cm3 and particle sizes belong to interval of 5-40 mcm, the polyethylene granules being used in the amount of at least 2% by mass from total composition mass; c) volatile silicon; d) emollient agent or mixture of two and more emollient agents; e) effective active antiperspirant agent quantity.

EFFECT: enhanced effectiveness and stability.

11 cl, 5 tbl

FIELD: medicine, dermatology, pharmacy.

SUBSTANCE: invention proposes a topical solution for treatment of solar lentiginosis and hyperpigmentated injures showing prolonged stability in storage and comprising the following components: (a) from about 0.5 to about 5 wt.-%/vol. of 4-hydroxyanisole; (b) from about 0.002 to about 0.05 wt.-%/vol. of tretinoin; (c) from about 2 to about 10 vol./vol.% of liquid low-molecular polyethylene glycol; (d) from about 0.001 to about 1.5 wt.-%/vol. of antioxidant or mixture of antioxidants. Antioxidants or mixtures of antioxidants are taken so to provide at least two functions of oxygen absorption, free-radical chain rupture or reduction: (e) from about 0.001 to about 0.1 wt.-%/vol. of chelating agent; (f) from about 50 to about 88 vol./vol.% of lower alcanol; and (g) water, up to 100%. Proposed solution has pH value from about 2.5 to about 5 and water content at least 12 vol./vol.%. Invention provides enhancing stability of the solution.

EFFECT: improved and valuable properties of composition.

13 cl, 1 ex

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