Method for predicting primary open-angle glaucoma at early stages of disease
FIELD: medicine, ophthalmology.
SUBSTANCE: the diagnostics of primary open-angle glaucoma (POAG) should be carried out at fulfilling unloading diagnostic sample based upon evaluation of the dynamics of the data of computed static perimetry. At detecting alterations in the parts of vision field being characteristic for glaucomatous process it is necessary to conduct unloading sample: after preliminary control of intra-ocular pressure it is important to apply per 1 drop of ophthalmological preparation "Travatan" retroblepharally and in 24 h one should carry out control measurement of intra-ocular pressure and repeat computed static perimetry. In case of improved retinal sensitivity at the background of decreased intra-ocular pressure the sample should be considered to be positive and POAG diagnosis should be established. The innovation enables to prescribe selective hypotensive therapy in due time.
EFFECT: higher accuracy and efficiency of diagnostics.
The invention relates to medicine, namely to ophthalmology, and is intended for the diagnosis of primary open-angle glaucoma (POAG) in the early stages of the disease.
So far not described any single, universal method, which gives the response of the patient the initial stages of primary open angle glaucoma, however, the success of medical and surgical treatment of patients with glaucoma depends on timely diagnosis, so the goal of improving the detection of the disease in the early stages of glaucoma process is very important.
There is a method of early diagnosis of primary open-angle glaucoma on the basis of a diagnostic unloading samples on Seasonally with canamericas control (Vol, sukhinina LB, Ustinov, H. Glaucoma, preleukemia, ocular hypertension. L., "Medicine". - 1985. - P.148). When setting the sample locally installerede 1% solution of pilocarpine.
The disadvantage of this method are frequent complaints in patients on eye redness, burning, pain in the head and eyeballs, blurred vision (due to the contraction of the pupil).
There is a method of fasting samples with oral administration of acetazolamide (diakarba) - carbonic anhydrase inhibitor (Flammer j, Drance S.M. Effect of acetazolamide on the differential threshold. - Arch. Ophtalm., 1983, vo.101, No. 9, p.1378-1380).
The disadvantage of this method is the possible systemic effect of diuretic, associated with changes in the level of electrolytes and alkaline reserve of the blood. In addition, the presence in most patients, concomitant General pathology (diseases with impaired renal function, prostatic hypertrophy, atrial fibrillation), there is no widely used diacarb. Reduction of circulating blood volume after diuretic effect paradoxically sometimes leads to spasm of peripheral vessels and the risk of elevated BP (Maren TH. The relation between enzyme inhibition and physiological response in the carbonic anhydrase system. //J. Pharmacol. Exp. Ther, 1963. - P.140-153).
The closest analogue of the proposed method is a method of determining the level of real tolerant of intraocular pressure with the study of the critical frequency of flicker fusion (Navratilova On the role of determining the level of true tolerance intraocular pressure in myopic patients with suspected glaucoma. // Glaucoma: problems and solutions: all-Russian scientific-practical conference: Sat. the scientific. senior - M., 2004. - S-110). This study used topically β-blocker (0.5% solution artiola) and carbonic anhydrase inhibitor dorzolamide (trusopta 2%).
The main drawback of all these methods of examination - impossibility (confirmation of diagnosis) based on the results of ASCS is adavani selectively assign effective antihypertensive treatment. Otherwise, antihypertensive therapy empirically selected drug can be not only ineffective but also harmful, because it can cause negative or paradoxical reaction to the drug.
Known methods of conducting drug tests in patients with primary open-angle glaucoma before assigning pilocarpine (Navratilova, Early diagnosis, peculiarities of clinical manifestations and treatment of open angle glaucoma in myopia: author. of thesis ... Dr. med. Sciences - M., 2004. - P.39).
However, given the often arise in the preparation of the above complaints and relatively low efficiency - pilocarpine today is not the drug of choice in the treatment of primary open-angle glaucoma.
Currently in ophthalmology for holding antihypertensive therapy uses synthetic analogue of prostaglandin - Travatan"reducing intraocular pressure at 30-35% of the original most physiological way - by increasing the outflow of aqueous humor within 24 hours after a single instillation (Netland, PA, Landry T, Sullivan EK, Andrew R, Silver L, Weiner A, Mallick S, Dickerson J, Bergamini MVW, Robertson SM, Davis AA, and the Travaprost Study Group. Am J Opthalmol 2001; 132:472-484). According to some researchers pronounced hypotensive effect was achieved more than 50% of patients with primary open-angle glauc is my using "Travatan" (Goldberg I., et al., J Glaucoma, 2001, 10, 414-422).
However, for the production of diagnostic tests this drug was not used.
The most widespread diagnostic specimens, where as the evaluation criterion was studied the dynamics of the field of view. In full and with a high degree of accuracy static perimetry can only be performed on modern computerized analyzers, field of view, ensuring the standardization of all variables of the study (Balashevich L.I. research Methods of the field of view. SPb.: Publishing house of St. Petersburg maps., 2004. - P.9).
The technical result is to increase the accuracy of diagnosis of primary open-angle glaucoma in the early stages.
The technical result is achieved by the fact that a diagnosis of primary open-angle glaucoma is carried out with setting the discharge diagnostic tests based on the evaluation of the dynamics data computer static perimetric studies computer perimeter "Medmont M700" company "Medmont Pty Ltd (Australia). When detecting changes in the characteristic glaucomatous process areas of the field of view was done unloading the sample: after the preliminary control of intraocular pressure, the eyelids of both eyes once instilled 1 drop of ophthalmic drug "Travatan". After 24 hours, conducted the completed measurement of intraocular pressure and repeated computerized static perimetry. While improving the sensitivity of the retina on the background of reduction of intraocular pressure, a sample is positive, diagnosed with primary open-angle glaucoma.
The method was carried out as follows. Conducted static perimetry computer perimeter "Medmont M700" company "Medmont Pty Ltd (Australia). To determine the sensitivity of the retina was used a template system test for glaucoma by 104 points with a threshold strategy of the research. The brightness of the surface of the hemisphere, which serves as the backdrop for demonstrations of test objects was 31.5 apostilb. Exposure time of presentation of each stimulus was 0.2 with (according to the recommendations of the International perimetric society, 1979). Control fixation technique is Heijl-Krakau with randomized presentation of stimuli in the field of the blind spot. Registration and processing of data the study was carried Russified standard software Medmont Studio, version 3.5.9. Estimated total change of sensitivity in each of the four quadrants of the visual field.
When detecting changes in the characteristic glaucomatous process areas of the field of view was done unloading the sample. After preliminary measurements of intraocular pressure, konyunktivalny cavity instilled 1 drop of ophthalmic drug is "Travatan". Control measurement of intraocular pressure and computerized static perimetry was performed 24 hours after instillation of the drug. While improving the sensitivity of the retina on the background of reduction of intraocular pressure, a sample is positive, sets the diagnosis of glaucoma.
Example 1. Patient W., 77 years. Outpatient map No. 13785. Directed by the district ophthalmologist for further examination with a diagnosis of both eyes: initial age-related cataract, suspected glaucoma. Complaints: the sense of "seriousness" in the eyes of periodic worsening of vision - foggy image. Visual acuity of the right eye with correction = 1.0 in the left eye with correction = 0,8. Tonometry on Maklakova right eye = 23 mm Hg, left eye = 25 mm Hg When conducting kinetic perimetric studies of visual field defects not detected. On the map computer static perimetric studies (glaucoma test) sites have been identified depression in typical for glaucoma areas. Spent unloading the sample: for the eyelids of both eyes once poured 1 drop of ophthalmic drug "Travatan". At the control measurement after 24 hours of intraocular pressure (Maklakov): right eye = 15 mm Hg, left eye = 17 mm Hg In all four zones marked improvement in the sensitivity of the retina. Right eye: Verninskoe quadrant +31 dB, dims the nasal quadrant +15 dB verkhneisetsky quadrant +16 dB, negnevitsky quadrant +4 dB. Left eye: Verninskoe quadrant +77 dB, niinamesai quadrant +7 dB, verkhneisetsky quadrant +14 dB, negnevitsky quadrant +9 dB. Thus, on the background of lowering intraocular pressure of 8 mm Hg was observed an improvement of visual functions, in particular an increase in the sensitivity zone Y and medial areas of the nasal halves. Improvement of visual functions associated with the restoration of conductivity arcuate bundle of nerve fibers against lowering IOP, i.e. improvement of the axons of the ganglion cells and explanationsthe current in them. Diagnosed with primary open-angle glaucoma, taking into account the results of the sample treatment: the eyelids of both eyes "Travatan" 1 drop at night, every day, constantly. At the control examinations during the month of intraocular pressure stably compensated (16-18 mm Hg in both eyes), the negative dynamics of visual functions is missing.
Example 2. Patient M., 50 years. Outpatient map No. 14121. Directed by the district ophthalmologist for further diagnosis. Complaints: notes periodically sense of "pressure" in the eyeballs, and pain in the frontal region. The diagnosis at the direction of both eyes: presbyopia, suspected glaucoma; left eye: hypermetropia low degree of astigm what magnetism, amblyopia weak. Visual acuity of the right eye without correction = 1.0, the left eye with correction = 0,5. Tonometry on Maklakova right eye = 25 mm Hg, left eye = 25 mm Hg When conducting kinetic perimetric studies of visual field defects not detected. On the map computer static perimetric studies (glaucoma test) sites have been identified depression in typical for glaucoma areas. Spent unloading the sample: for the eyelids of both eyes once poured 1 drop of ophthalmic drug "Travatan". At the control measurement after 24 hours of intraocular pressure (Maklakov): right eye = 16 mm Hg, left eye = 17 mm Hg In all four zones marked improvement in the sensitivity of the retina. Right eye: Verninskoe quadrant + 52 dB, niinamesai quadrant +69 dB, verkhneisetsky quadrant +58 dB, negnevitsky quadrant +34 dB. Left eye: Verninskoe quadrant +6 dB, niinamesai quadrant +6 dB, verkhneisetsky quadrant +20 dB, negnevitsky quadrant +8 dB. A patient diagnosed with both eyes: primary open-angle glaucoma taking into account the result of the sample assigned to antihypertensive mode: behind the eyelids of both eyes "Travatan" 1 20.00 daily, constantly. At the control examination within 2 months of complaints on the eyes no registered stabilization of intraocular pressure level 16-19 mm Hg (both eyes), neg is supplemented flax dynamics of visual functions is missing.
Example 3. Patient M., 53. Outpatient map No. 13547. The complaint: frequent change of presbyopic correction, blurred vision after optic load near. The diagnosis of both eyes: presbyopia and suspected glaucoma. Visual acuity of the right eye without correction = 1.0 in the left eye without correction = 1,0.
Tonometry on Maklakova right eye = 24 mm Hg, left eye = 23 mm Hg When conducting kinetic perimetric studies of visual field defects not detected. On the map computer static perimetric studies (glaucoma test) sites have been identified depression in typical for glaucoma areas. Spent unloading the sample: for the eyelids of both eyes once poured 1 drop of ophthalmic drug "Travatan". At the control measurement after 24 hours of intraocular pressure (Maklakov): right eye - 6 mm Hg, left eye 4 mm Hg According to a computer perimetric studies in all four areas noted improvement in sensitivity. Right eye: Verninskoe quadrant +76 dB, niinamesai quadrant +46 dB, verkhneisetsky quadrant 18 dB, negnevitsky quadrant +41 dB. Left eye: Verninskoe quadrant +97 dB, niinamesai quadrant +89 dB, verkhneisetsky quadrant +21 dB, negnevitsky quadrant +9 dB. A patient diagnosed with both eyes: primary open-angle glaucoma taking into account the result of the sample assigned to antihypertensive treatment is: for the eyelids of both eyes "Travatan" 1 20.00 daily constantly. At the control examination within 2 months: complaints are not really marked stabilization of intraocular pressure at the level of 17-19 mm Hg (both eyes), the negative dynamics of visual functions is missing.
When the research was confirmed a pronounced hypotensive effect of ophthalmic drug "Travatan", which makes the test more reliable. In addition, the reduction of intraocular pressure by 1 mm Hg reduces the risk of progression of glaucomatous process by 10% (according to a multicenter clinical study of the Early Manifest Glaucoma Trial EMGT).
The mechanism of action of Travatan does not reduce the volume of produced intraocular fluid, therefore, have less of an impact on the trophism of the layers of the eyeball, which can reduce costs registrationthe treatment.
In the tests, the patient receives objective information about the reason for selecting the hypotensive drug.
To date in the evaluation of patients with suspected glaucoma was not included preliminary evaluation of the effectiveness of a drug for a follow up appointment antihypertensive therapy. The patient had about 30 days is appointed to resolve the question of the effectiveness of the drug and further tactics of treatment. Thus, IP is the use of the proposed method can improve the efficiency of detection of primary open-angle glaucoma in the early stages of the disease.
Method for the diagnosis of primary open-angle glaucoma in the early stages of the disease, including static perimetry, characterized in that in the presence plots depression in typical for glaucoma areas of the patient is carried out installation in konyunktivalny cavity 1 drops "Travatan and after 24 h is held control perimetry, while improving the sensitivity of the retina on the background of reduction of intraocular pressure, a sample is positive, diagnosed with primary open-angle glaucoma.
FIELD: medicine, surgery.
SUBSTANCE: during the period of 5 d before operation and 10 d after it is important to prescribe the intake of ADP-37 preparation for patients at the dosage of 6 capsules/d. The innovation enables to decrease traumatism of prophylactic procedures carried out at pre- and post-surgical stages.
EFFECT: higher efficiency of prophylaxis.
SUBSTANCE: it has been suggested to apply a preparation for preventing and correcting cerebral circulation in elderly and senile age that improves functional cerebral activity - the reindeer's blood dried due to deep vacuum dehydration. The preparation decreases the disorders of cerebral blood system by the index of regulatory systems' tension and improves affected cerebral circulation in aging animals induced by aging alterations of physiological functions.
EFFECT: higher efficiency.
3 ex, 6 tbl
FIELD: radiation veterinary science, medicine, hygiene.
SUBSTANCE: the suggested capsule contains the powder of reduced iron, a binding substance as wax and ferrocin as an enterosorbent being active against radionuclides at the following ratio of the ingredients mentioned, weight%: ferrocin 40, the powder of reduced iron 40, bee wax 20, moreover, the capsule is designed as a cylindrical pill with a conic blunt end. The innovation enables to withdraw radionuclides out of animal body successfully.
EFFECT: higher efficiency of binding.
SUBSTANCE: method involves irradiating tumor in trans-scleral and transpupillary mode with laser radiation using photodynamic therapy approach with Photosense photosensibilizer being applied. Irradiation is administered 48-72 h later, after having introduced the photosensibilizer with radiation source having wavelength of 675 nm and luminous radiation dose of 80-800 mW/cm2. Photodynamic therapy is applicable first in transcleral mode and then in transpupillary mode. It is also applicable first in transpupillary mode and then in trans-scleral mode.
EFFECT: enhanced effectiveness in optyimizing treatment.
FIELD: medicine, sport medicine.
SUBSTANCE: invention proposes dosing bactisporin as pharmacological preparation. Bactisporin is dosed orally to sportsmen 2-3 months before competition in training period by 2 doses, once per 24 h, every other day, tenfold. Invention provides expanding field in using bactisporin as a nondoping agent for enhancing body protective power, physical working capacity, muscle mass, detoxification function of liver, rate in recovery after stressed muscle activity.
EFFECT: improved enhancing method.
2 tbl, 2 ex
FIELD: medicine, surgery.
SUBSTANCE: it is necessary to fulfill subtotal subfascial resection of both thyroid lobes at keeping the layer of its tissue along posterior-medial surface at the quantity of 4-6 g/each lobe. Moreover, after resection before suturing the wound one should conduct intrasurgical stimulation of regeneration of residual thyroid tissue due to introducing 1-2 ml complex allogeneic biomaterial into parenchymatous thickness at the following ratio: 40-50 mg biomaterial per 1 ml physiological solution, moreover, complex biomaterial is being a multi-component composition that includes, weight%: vasculogenesis stimulant 40-50, regeneration stimulant 40-50, specific thyrotropic stimulant 5-10 which should be prepared as the following: one should purify allogeneic donor's thyroid gland to remove the residues of adjacent tissues and reduce it into small pieces and wash in running water for about 5-19 min, then thrice one should rinse it with 0.9%-sodium chloride solution, then tissues should be frozen and freeze dried under vacuum to reduce dried tissues, pack into glass vials and sterilize with γ-radiation at the dosage of 2.5 Mrad. The innovation provides rapid revascularization of thyroid stump, development of a full-value connective tissue, enables to suppress autoimmune activity to residual thyroid tissue in postsurgical period.
EFFECT: higher efficiency of therapy.
5 dwg, 1 ex
FIELD: medicine, immunology.
SUBSTANCE: solution of "BTSH70" preparation in dose of 1.12 lg DL50.ml is administered ones daily intranasally to white mouse infected by Venezuelen equine encephalitis virus in dose of 15 mug/mouse for three days before and for five days after contamination. Method of present invention makes it possible to bind newly synthesized or damaged polypeptides followed by reducing of structure thereof or reducing thereof from cell.
EFFECT: method for increasing of organism strength to dangerous damage effects.
3 dwg, 1 tbl, 1 ex
FIELD: medicine, veterinary science.
SUBSTANCE: it is necessary to introduce chemically pure glycerol for animals, moreover, before introduction it should be dissolved with distilled water at 1:1 ratio at the dosage of 2 ml/kg body weight, as for its introduction for people it is necessary to introduce 30 ml glycerol dissolved in 200 ml distilled water as a single dosage. The present innovation enhances transformation of highly toxic ammonia into intoxic compound - urea, that, in its turn, enables to reconstruct nitrogenous metabolism and improve health state in animals and people.
EFFECT: higher efficiency.
FIELD: medicine, oncology, pharmacy.
SUBSTANCE: invention describes a medicament used in treatment of liver disease by prevention of invasion onset of portal vein. This agent represents the effective medicament containing menatetrenone as an active component used in treatment/prophylaxis of liver disease. Indicated agent used in treatment/prophylaxis of liver disease is the effective medicament against liver cancer, in particular, against DCP (des-γ-carboxyprothrombin)-positive liver cancer. Agent used in aims for treatment/prophylaxis of liver disease contains menatetrenone as an active component, it improves prognosis significantly after carrying out the anticancer therapy and possesses the excellent effect directed on prevention of liver cancer relapses.
EFFECT: valuable medicinal property of agent.
4 cl, 2 tbl, 10 dwg, 2 ex
FIELD: biology, medicine, in particular treatment and prophylaxis of various infection diseases.
SUBSTANCE: invention relates to Aerococcus viridans strain D-7069 having anti-microbial activity and is useful in production of drug for treatment and prophylaxis of various infection diseases. Pharmaceutical agent contains therapeutically effective amount of lyophilized vegetative cells of Aerococcus viridans strain D-7069 and pharmaceutically acceptable carrier.
EFFECT: strain with high anti-microbial activity.
2 cl, 4 tbl, 3 ex
FIELD: medicine, ophthalmology.
SUBSTANCE: method involves administration of the preparation "Ginkor-Fort" in the dose 1 tablet, 2 times per a day for 2 weeks and after one month break the preparation "Diovenor" is administrated in the dose 1 tablet, once per a day for 2 weeks at the constant instillation of the preparation "Ksalatan" in the dose 1 drop, once time before night. Such schedule of the method provides the stable normalization of intraocular pressure based on improvement of venous orbital and cerebral circulation. Invention is designated for medicinal treatment of glaucoma discirculatory variant.
EFFECT: improved method of treatment.
2 tbl, 1 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to a purgative agent composition comprising bicyclic compound of the formula (1) and a method providing the purgative effect and using compounds of the formula (1). He composition possesses the enhanced effectiveness.
EFFECT: valuable medicinal properties of composition.
42 cl, 3 tbl, 2 ex
FIELD: chemico-pharmaceutical industry.
SUBSTANCE: the suggested composition contains prostaglandin-like compound as an active component and it , also, deals with the method to treat disorders of external secretion that includes application of efficient quantity of prostaglandin-like compound for a person who needs such a treatment. The composition is of high efficiency at treating disorders inactivity of lacrimal and sudoriferous glands being of high bioavailability and nontoxic.
EFFECT: higher efficiency of therapy.
33 cl, 5 ex, 7 tbl
FIELD: medicine, obstetrics.
SUBSTANCE: invention relates to a method for treatment of delivery activity weakness. Method involves simultaneous administration of prostaglandin F2α in the concentration 12.5 mcg/ml at the rate 8 mcg/min and adenosine triphosphate sodium in the concentration 0.25 mcg/ml at the rate 0.25 mcg/min. Infusion continues up to end of the second stage of delivery. Method provides enhancing the delivery activity, increasing rate of uterine orifice opening on the background of the reduced dose of prostaglandin.
EFFECT: improved treatment method.
FIELD: medicine, chemical-pharmaceutical industry.
SUBSTANCE: invention relates to new applying EP4 receptors agonist for treatment and/or prophylaxis of diseases associated with loss of osseous mass. Agonists of EP4 receptors show high effectiveness in treatment of diseases associated with loss of osseous mass, among the, as osteoporosis of different genesis. Agonists of EP4 receptors involve prostaglandin skeleton base.
EFFECT: valuable medicinal properties of pharmaceutical composition.
16 cl, 3 tbl, 5 ex
FIELD: organic chemistry, medicine.
SUBSTANCE: invention relates to 1-ethanolamide PGF2α of formula I useful in relaxation of mammalian intraocular pressure. Claimed substance unlike majority of ocular hypotensive prostaglandins doesn't effect through FP-receptor.
EFFECT: new effective compound for relaxation of mammalian intraocular pressure.
4 cl, 1 ex, 16 dwg, 16 tbl
FIELD: animals science.
SUBSTANCE: the present innovation deals with intramuscular injection of sodium salt preparation cloprostenol 30-45 min before placing at the dosage of 750 mcg/animal. The method provides increased reproductive function, enhances sexual reflex, increases the volume of ejaculate, concentration, activity and quality of spermatozoa.
EFFECT: higher efficiency of breeding.
2 ex, 3 tbl
FIELD: veterinary science.
SUBSTANCE: a sow should be twice injected with oxytocin and, additionally, intramuscularly about 2-4 h after afterbirth detachment one should introduce clathroprostin at the dosage of 1 ml. The innovation suggested is very efficient in preventing metritis-mastitis-agalactia and endometritis in sows, as well.
EFFECT: higher efficiency of prophylaxis.
1 ex, 1 tbl
FIELD: medical equipment.
SUBSTANCE: device for inspecting field of view has demonstration screen with perforations and light point test-objects in form of light-emitting diodes which are shown to patient. Fixation light test-object is fastened to surface of screen along its central axis. Device has spheroid-shaped case with handle and multi-digit bus for connecting light-emitting diodes to control unit and power voltage source. Demonstration screen is mounted in cavity of case to make gap with it. Screen is made in form of hollow sphere. Peep window is made in case and demonstration screen to see light test-objects. Peep window is made in front of fixation light test-object. Case, demonstration screen and peep window have diameters of (2,25-2,4)L, (1,75-1,9)L and (0,85-1,1)L correspondingly, where L is horizontal size of human eye-socket.
EFFECT: widened borders of filed of view; provision of diagnostics at early stage of disease; improved quality of inspection.