Method for chemoradiation therapy of brain malignant glial tumor

FIELD: medicine, oncology.

SUBSTANCE: method involves carrying out lumbal puncture to a patient in post-operative period, subarachnoid space is catheterized, and 5 ml of liquor is removed followed by incubation of liquor with nimustine taken in the dose 5 mg in vitro at temperature 38°C for 30 min, and liquor is administrated into subarachnoid space through catheter. Procedure is carried out 2 times with interval for 7 days. Since the second day after onset of this procedure distant gamma-therapy on bed of removed tumor is carried out up to the total focus dose 60 Gr. Method provides stable remission, decreasing toxicity of chemopreparation, frequency of adverse by-side effects and significant reducing the cost of chemotherapy. Invention can be used in carrying out the adjuvant chemoradiation therapy of brain malignant glial tumors.

EFFECT: improved method of chemoradiation therapy, enhanced effectiveness of method.

1 ex

 

The invention relates to medicine, namely to Oncology, and can be used for adjuvant chemoradiation therapy of malignant glial tumors of the Central nervous system.

There is a method of treatment of malignant glial brain tumors by the combination of remote gemmoterapii with systemic chemotherapy drugs nitrosodiethylamine (Minesh Mehta, USA, "Combination therapy in malignant gliomas", Proceedings of the 12th conference on Oncology, Denmark, 21-25.09.2003, p.5), chosen as a prototype

The disadvantages of the method of treatment of malignant glial brain tumors are of low efficacy and high toxicity of chemotherapy.

The aim of the invention is to increase the efficiency and reduce the toxicity of treatment of malignant glial brain tumors.

This objective is achieved in that in the postoperative period the patient perform a lumbar puncture, kateteriziruyut subarachnoid space, take 5 ml of the liquor, incubated liquor with nimustine 5 mg in vitro at a temperature of 38°C for 30 minutes and injected through the catheter into the subarachnoid space, the procedure is carried out 2 times with an interval of 7 days. On day 2 start remote gamma-therapy is recommended (DHT) on the bed of the remote SDA is Oli daily for 20 days up to a total focal dose of 60 Gy. The invention "Method chemoradiation therapy of malignant glial brain tumors" is new, as it is not known from the level of medicine in the field of chemoradiation therapy of glial brain tumors.

The novelty of the invention lies in the fact that for the treatment of malignant glial brain tumors using the introduction of nimustine on autorequire through endolyumbalno catheter in combination with DHT.

The invention is industrially applicable as it can be used in health care, in medical institutions for the treatment of patients with tumors of the Central nervous system, cancer research institutes, breast care clinics and other clinical settings.

"The way chemoradiation therapy of malignant glial brain tumors" as follows:

in the postoperative period the patient perform a lumbar puncture needle (Tuohy, kateteriziruyut the subarachnoid space. Take the cerebrospinal fluid of a patient in an amount of 5 ml and incubated with the cancer - nimustine 5 mg in vitro at a temperature of 38°C for 30 minutes, and then endolyumbalno administered to the patient. The procedure is carried out twice with an interval of 7 days. On day 2 start remote gamma-therapy is recommended on the removed tumor bed daily for 20 days to total Chasovoy dose of 60 Gy.

Specific example

"How chemoradiation therapy of malignant glial brain tumors"

Patient L-C H. C.,1989/R, case history No. 483/t, enrolled in the Department. INC RNII 20.01.2004 diagnosed with: medulloblastoma IV ventricle. Condition after suboccipital lymphadenopathy craniotomy with Subtotal removal of the tumor (23.12.2003,, RSMU, g/a No. 25924 - 31/03 - medulloblastoma). Admission: moderate cerebral m, expressed cerebellar ataxia; Karnofsky index was 50%, General health status who is 3 points. 20.01.04, - 12.02.2004 was held in the course of DHT SOD 60 Gy with intrathecal by autolymphochemotherapy (ALHT) nimustine 10 mg. Moved ALHT satisfactory - complications and side effects not. From 30.03. on 15.09.2004 was held for another 3 courses of intrathecal ALHT - 10 mg of nimustine. Portability ALHT satisfactory complications and side effects not. On CT brain 14.12.2004, in the zone of removal of the tumor of the left hemisphere of the cerebellum relapse no, liquor cavity, soamsawali with the fourth ventricle. Other parts of the brain - without lesions. The median structure without bias. After 4 courses of intrathecal chemotherapy the patient's condition is satisfactory, slight cerebral symptoms. Index on a scale Karnofsky 80%of the General status who is 1 point.

Techno-economic the th efficiency

"How chemoradiation therapy of malignant glial brain tumors" is that the use of nimustine in adjuvant endolyumbalno chemotherapy on autorequire in combination with remote gamma-therapy is recommended on the bed of the removed tumor allows to achieve stable remission after resection of malignant glial brain tumors, to reduce the toxicity of cytostatic agents, the incidence of side effects and thus increase the effectiveness of chemotherapy while significantly reducing its cost.

The way chemoradiation therapy of malignant glial brain tumors, including endolyumbalno introduction of hemipleat, characterized in that in the postoperative period the patient perform a lumbar puncture, kateteriziruyut subarachnoid space, take 5 ml of the liquor, incubated liquor with nimustine 5 mg in vitro at a temperature of 38°C for 30 min and injected through the catheter into the subarachnoid space, the procedure is carried out 2 times with an interval of 7 days, from the 2nd day of the beginning of the procedures performed remote gamma-therapy is recommended on the bed of the removed tumor to the total focal dose of 60 Gy.



 

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3 ex

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1 ex

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