Method of preparation of tritium-labeled humic substances and humic-like materials

FIELD: labeled natural substances.

SUBSTANCE: invention provides a method for labeling humic and humic-like substances with tritium-containing agent, said agent being atomic tritium obtained via thermal catalytic dissociation of tritium on tungsten wire at pressure 0.3-0.6 Pa. Humic and humic-like substances are preliminarily deposited on reaction vessel walls utilizing lyophilization for aqueous solutions thereof. Thermal dissociation is effected by 5-10-sec pulses at tungsten wire temperature 1900-2000 K.

EFFECT: enabled uniform introduction of tritium and achieved radiation activity of preparation 69 to 254 GBc/g.

1 dwg, 2 tbl, 15 ex

 



 

Same patents:

FIELD: organic chemistry, labeled compounds, pharmacy.

SUBSTANCE: invention relates to a novel [3H]-fluvastatin of the formula: highly labeled with tritium with molar radioactivity 40-45 Ci/mmole. This compound can be used in analytical chemistry, biochemistry and applied medicine.

EFFECT: valuable properties of compound.

1 ex

FIELD: organic chemistry, labeled compounds.

SUBSTANCE: invention relates to a novel compound - 2-amino-4-(β-hydroxyethylamino)anisole uniformly labeled with tritium The compound can be used in analytical chemistry and biological investigations. Early non-labeled 2-amino-4-(β-hydroxyethylamino)anisole is used as a dye.

EFFECT: valuable properties of compound.

1 ex

FIELD: organic chemistry, labeled compounds.

SUBSTANCE: invention relates to a new highly labeled compound that represent an analog of the known physiologically active compound that is the strongest toxin and inhibitor of some viable important processes, for example, sodium ions transporting. [3H]-Saxitoxin dihydrochloride highly labeled with tritium corresponds to the formula: .

EFFECT: valuable properties of compound.

1 ex

The invention relates to a new vysokomernoa butyrylcholine formulas [3H]C3H7-COO-CH2-CH2-N+(CH3)3Cl-that is an analogue of butyrylcholine and may find application in analytical chemistry, Bioorganic chemistry, biochemistry and applied medicine, in particular for determining the activity of cholinesterase.

The invention relates to the field of organic chemistry and can find application in analytical chemistry, Bioorganic chemistry, biochemistry and applied medicine

The invention relates to a method of radioactive labeling of proteins of therapeutic radioactive isotope for administration to a patient, namely, that mix chelator conjugated with a protein or peptide with a solution containing a radioactive isotope or its salts, acceptable buffer, incubated for sufficient time and at an acceptable pH and temperature, obtain the target product with a radiochemical purity greater than 95%, sufficient specific activity and binding specificity of at least about 50%, the resulting product may be injected directly into the patient without further purification; and a kit for implementing the method, representing the vial, containing chelator conjugated with a protein or peptide in an acceptable buffer, a vial containing a buffer composition for stabilization and injection of radioactively labeled protein or peptide to the patient and instructions for the procedure of radioactive tagging

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The invention relates to labeled steroids, specifically to vysokomernoa tritium-hydroxyestra-1,3,5(10)-triene-17-huili-östra-1,3,5(10)-triene-3,17-diolo General formula I, where R = 0 or R = -HE

The invention relates to a new vysokomernoa tritium ethyl(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate of the formula I

The invention relates to a new compound - tritium-labeled tartino and method for determining taphrina in biological samples, including the introduction of pre in the sample vysokobarnogo tritium captina, extraction, transformation into the prepared extract captina and its labeled analog in them benzoic or ortho-derivative, which is then analyzed by HPLC with fluorescence detection

The invention relates to synthetic binding with the receptor calcitonin compound having a molecular weight of less than 10,000 D, which is a peptide covalently attached to the chelator radioactive metal with the formation of the reagent, with the above-mentioned reagent exhibits affinity for binding to the calcitonin receptor, equal to or greater than the affinity of binding with these receptors characteristic of the native, tagged with radioactive iodine calcitonin

The invention relates to compounds of the formula Y-(CR2)n-X-NHJ, where X represents C=O or CR2; n is an integer having a value of from 1 to 6; Y is an L(A)mor R1R2CR-, where L - metallocomplexes agent, And represents-CR2-, -NRCO-, -CONR - or polyalkyleneglycol; m is an integer having a value of from 0 to 10, where one of R1and R2is-NH(B)pZ1and the other is-CO(B)qZ2where p and q are integers having a value of from 0 to 20, and each independently selected from Q or amino acid residue, where Q is a cyclic peptide; Z1and Z2- protective groups which are biocompatible group which inhibits or suppresses the metabolism of the peptide in vivo; J and each R group is independently selected from H, C1-4the alkyl or C1-4alkoxyalkyl; provided that (i) the total number of amino acid residues in R1and R2the group does not exceed 20; (ii) if X is CR2then Y is-CRR1R2and Z2is metallocomplexes agent; (ii) if Y is-CRR1R2then at least one of R1and R2carries at least one frequent detektiruya

FIELD: organic chemistry, labeled compounds.

SUBSTANCE: invention relates to a new highly labeled compound that represent an analog of the known physiologically active compound that is the strongest toxin and inhibitor of some viable important processes, for example, sodium ions transporting. [3H]-Saxitoxin dihydrochloride highly labeled with tritium corresponds to the formula: .

EFFECT: valuable properties of compound.

1 ex

FIELD: organic chemistry, labeled compounds.

SUBSTANCE: invention relates to a novel compound - 2-amino-4-(β-hydroxyethylamino)anisole uniformly labeled with tritium The compound can be used in analytical chemistry and biological investigations. Early non-labeled 2-amino-4-(β-hydroxyethylamino)anisole is used as a dye.

EFFECT: valuable properties of compound.

1 ex

FIELD: organic chemistry, labeled compounds, pharmacy.

SUBSTANCE: invention relates to a novel [3H]-fluvastatin of the formula: highly labeled with tritium with molar radioactivity 40-45 Ci/mmole. This compound can be used in analytical chemistry, biochemistry and applied medicine.

EFFECT: valuable properties of compound.

1 ex

FIELD: labeled natural substances.

SUBSTANCE: invention provides a method for labeling humic and humic-like substances with tritium-containing agent, said agent being atomic tritium obtained via thermal catalytic dissociation of tritium on tungsten wire at pressure 0.3-0.6 Pa. Humic and humic-like substances are preliminarily deposited on reaction vessel walls utilizing lyophilization for aqueous solutions thereof. Thermal dissociation is effected by 5-10-sec pulses at tungsten wire temperature 1900-2000 K.

EFFECT: enabled uniform introduction of tritium and achieved radiation activity of preparation 69 to 254 GBc/g.

1 dwg, 2 tbl, 15 ex

FIELD: engineering of technical means for marking chemical substances, possible use for marking any substances.

SUBSTANCE: an admixture is introduced into substance being marked, of same chemical composition as substance, but with increased content of rare stable isotopes (carbon, oxygen, nitrogen, hydrogen) of several elements present in composition of substance being marked. Used as marking code is value of concentration of rare isotopes introduced to substance being marked.

EFFECT: creation of universal, safe to use marker, useable for reliable identification of any substances without affecting their consumer qualities.

3 cl

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to 3-piperidinoethylphenylketones of the general formula (I): wherein R means nondeuterated, mono- or multi-deuterated or perdeuterated alkyl comprising up to 3 carbon atoms; all radicals R' represent hydrogen atom, or all represent deuterium; radicals R'' represent independently of one another deuterium or hydrogen atom wherein at least one of radicals R, R' or R'' represents deuterium or comprises deuterium, and to their physiologically tolerant salts. Compounds of the formula (I) and their salts can be used in treatment of diseases associated with symptoms in muscular region, such as morbid reflex-muscular tensions of skeletal musculature and/or nervous-muscular convulsions.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

5 cl, 5 dwg, 10 ex

FIELD: radiolabeled compounds, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to a novel physiologically active uniformly tritium-labeled compound, namely, [3H]-14-hydroxydaunomycin of adriamycinone of the formula (I): .

EFFECT: valuable medicinal property of compound.

1 dwg, 1 ex

FIELD: radiolabeled compounds, biochemistry.

SUBSTANCE: invention relates to a novel labeled analogue of the physiologically active compound, namely, tritium-labeled acyl-coenzyme A of the general formula (I): wherein Acyl means [5,6-3H]-(5,6-dihydro)-arachidonoyl or [6,7-3H]-linoleyl.

EFFECT: valuable medicinal and biochemical properties of compound.

2 dwg, 4 ex

FIELD: organic chemistry, radiolabeled compounds.

SUBSTANCE: invention relates to a novel chlorohexidine highly labeled with tritium of the formula: with molar radioactivity 17 Cu/mole. The compound possesses the strong disinfecting and antibacterial effect and can be used in analytical chemistry in investigation of effect of this compound.

EFFECT: valuable properties of compound.

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of saturated aliphatic carboxylic acids with stable carbon isotopes (1-13C). Method involves the hydrocarboxylation reaction of α-olefins with carbon monoxide (13CO) and water at temperature 100-170°C and under pressure not exceeding 5 MPa in the presence of a solvent and catalytic system containing palladium compound as complex PdCl2(PPh3)2 and triphenylphosphine PPh3 taken in the ratio from 1:2 to 1:100, respectively. Synthesized carboxylic acids can be used as diagnostic test-preparations in medicine practice and in criminology, scientific investigations and in other fields. Invention provides synthesis of enanthic acid and caprylic acid labeled by stable carbon isotope 13C at position 1 for a single step, to increase yield of acids as measured for isotope raw, to decrease cost price of acids and to obtain derivatives of (1-13C)-caprylic acid - (1-13C0-caprylate sodium and (carboxy-13C)-trioctanoine.

EFFECT: improved methods of synthesis.

9 cl, 6 ex

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