Method and device for mixing liquid medicament and gas in given doses

FIELD: medicine; medical engineering.

SUBSTANCE: method involves setting syringe body in horizontal position with additional end piece turned upward. Sealing caps are taken off from the principal and additional end pieces. Space is opened between syringe body and sealing member on the piston. The piston is moved into utmost position near tip for introducing gas. Additional rod is returned to initial position and syringe body is set in vertical position with the end piece turned down. Dosed volume of liquid drug is taken to graduation line. The principal and additional end pieces are tightly closed with cap. The syringe body is set in vertical position with the end piece turned down before usage. Space is opened between syringe body and sealing member on the piston by rotating the additional rod. The piston is displaced to dosed mark taking into account the line connecting the principal and additional graduation line. The additional rod is returned to the initial position. The liquid drug is mixed w the gas substance during 15 min. Then, sealing cap is taken off from the end piece. Needle is put on. Gas substance not mixed with the liquid drug is removed by displacing piston to dosed mark along liquid drug graduation mark.

EFFECT: reduced risk of traumatic complications.

3 cl, 2 dwg

 

The invention relates to medicine, to methods dosed mixing liquid medicines with gaseous substance and relates to devices for their implementation.

For injuries involving soft tissue hypoxia, prehospital locally injected oxygenated perftoran (Patent of Russian Federation №2237473, bull. No. 28, 10.10.2004). This raises the need for mixing of perftoran with oxygen. Sooner will be introduced oxygenated perftoran in the affected tissue, the more opportunities to prevent reperfusion changes, prevention of purulent-necrotic complications and anaerobic infections, reducing deaths. When using the known syringe for mixing liquid medicines with gaseous substance prehospital it is impossible to ensure sterility, you must have two sterile needles for intake of oxygen and the introduction of liquid medicines. You cannot use oxygen for oxygenation of perftoran prehospital, if assistance is provided indoors, for example in the mine. Safety oxygen in the mine is prohibited. (Rules of safety in coal mines. In the book: "Instructions for carrying out hot work in the underground workings and surface buildings. Graphs LE and others, 1976. - s-349. The rights of the La safety in the coal industry, Shadow M.I. and others, 1986. - s).

There is a method of dispensing liquid medicines which fill the syringe with liquid medication and dispense it on-line calibration, placed on the body of the syringe (GOST 24861-91. Syringes injecting a single application. - M.: Publishing house of standards, 1992. - p.1-20).

The disadvantage of this method of dispensing liquid medications is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

There is a method of dispensing liquid medications by dialing into the syringe for liquid medicines, metered on-line calibration for the primary and secondary scale placed on the body of the syringe (Publishing House "RUSSIAN DOCTOR" Internet http://www.rusvrach.ru/ frticles/ms-01-03 str.10-13).

The disadvantage of this method of dispensing liquid medications is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

The closest in technical essence and the achieved effect is a method of forming the enriched gas fluid. Claim US 2003/0231982 A1, And 61 M 1/16, 18.12.2003. This method is adopted for the prototype.

The disadvantage of this method of dispensing W is dcih medicines is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

A device for dispensing liquid medications, including the body of the syringe with the rod, support rod, nozzle, piston, seal, located on the piston, line calibration button on the body of the syringe that allows dispensing a liquid drug by volume. (GOST 24861-91. Syringes injecting a single application. - M.: Publishing house of standards, 1992. - p.1-20).

The disadvantage of this device dispensing a liquid drug is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

It is known device for dispensing liquid medications, including the body of the syringe, the tip of the rod, the stop rod. The device allows you to dial in the syringe and dispense by volume or in terms of the medicines on-line calibration and additional line calibration (Publishing House "RUSSIAN DOCTOR", Internet http://www.rusvrach.ru/frticles/ms-01-03 str.10-13).

The disadvantage of this device dispensing a liquid drug is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

The closest in technical essence and the achieved effect is ustroystvo the formation of enriched gas fluid. Claim US 2003/0231982 A1, And 61 M 1/16, 18.12.2003. This unit is adopted for the prototype.

The disadvantage of this device is the inability dosed mixing liquid medicines with the gaseous substance in the syringe before the introduction of prehospital.

The technical result of the invention is to prevent complications of wounds dosed by mixing liquid medicines with the gaseous substance in the syringe prior to its introduction at the prehospital stage.

This technical result is achieved in that the device for the metered mixing liquid medicines with gaseous substance comprises the body of the syringe with stop finger tip and located on the frame line calibration, situated inside a rod with a piston at one end and a stop on the other, located on the piston seal, the housing opposite to the tip end near a stop for the fingers is made an additional tip, both tip sealed with removable caps. Inside the stem, at the end of the fence which is made of a label, an additional rod with a focus on the end face of which is made of risk, with additional stock made with the possibility of rotation for opening and closing of the gap between the current case the Itza and the seal of the piston. On the body of the syringe near the line calibration caused additional line calibration, as well as the line connecting the primary and secondary line calibration, while between the body of the syringe and the piston rod on the opposite side from the tip of the installed o-ring.

The method dosed mixing liquid medicines with gaseous substance is performed as follows: syringe fitted horizontally, additional tip up. Remove tightly installed caps on the primary and secondary nozzles. The additional rotation of the stem to open the gap between the body of the syringe and the seal placed on the piston, and the piston is moved to an extreme position near the tip, through which introduce a metered amount of gaseous substances. Additional stock return to its original position. The body of the syringe is transferred to the vertical position and place the tip down, trying to enter a metered amount of on-line calibration of liquid medicines, tightly closed with the cap main and additional tips. Before use of liquid medicines, the body of the syringe is transferred to the vertical position, with the tip down, the additional rotation of the stem to open the gap between the seal is archna and the body of the syringe. Move the piston to the measured level, focusing on the connecting line between the basic and additional line calibration, return the additional rod to its original position, within 15 minutes the liquid drug is mixed with a gaseous substance. Remove hermetically mounted cap with tip, put the needle, remove the gaseous substance is not mixed with the liquid drug, by shifting the piston to metered stamps on-line calibration of liquid medicines.

These objectives are achieved by the fact that as liquid medicines with gas transport function use perftoran, and as a gaseous substance use oxygen.

The invention is illustrated by drawings, where figure 1 shows a General view of the device; figure 2 shows the end of the lock stock and additional stock.

Device for dispensing liquid medications includes (see Figure 1): the body of the syringe 1 with tip 2 and additional tip 3, caps lugs 4. Inside the rod 5 has an additional rod 6. The piston 7 has the seal of the piston 8. Line calibration 9 for dispensing liquid medications and additional line calibration 10 for dispensing gaseous substances, line 11, 9 connecting the main and additional the ing line 10 calibration. Line 11 is designed to determine the required volume of gaseous substances necessary for metered mixing with the liquid drug. The sealing ring 12, which creates tightness of the cavity of the syringe, the stop rod 13, emphasis additional rod 14. Figure 2 shows the stop rod 13, emphasis additional rod 14 with the marks on the end of the stop rod "K" and "R" 15, risk at the end of the additional emphasis of the rod 16. When installed risk 16 on the end stops of additional stock against labels "To" 15, at the end of the stop rod there will be a gap between the seal 8 of the piston 7 and the wall of the housing of the syringe 1 and the oxygen passes through this gap. When installed risk 16 on the end stops of additional stock against the label "R" 15, at the end of the stop rod creates tightness between the seal 8 of the piston 7 and the wall of the housing of the syringe 1. This working "R" state of the syringe.

The method of dispensing liquid medications is as follows: the body of the syringe 1 have horizontally. An additional tip 3 come up. Remove tightly installed caps 4 with lugs 2 and 3. Turn additional rod 6, and the risk that at the end of the additional emphasis of the rod 16 is set to the "To" tag on the end of the stop rod 15, thus opening a gap between the body of the syringe 1 and what letsitele 8, located on the piston 7. By pressure on the end of the stop rod 13 and the end stops of additional rod 14 of the piston 7 moves to an extreme position near the tip 2. Through the tip of introducing a metered amount of gaseous mixture. Risk on the additional end of the rod 16 will return to its original position "P" is a label on the end of the lock rod 15, thus closing the gap between the seal 8 of the piston 7 and the body of the syringe 1. The body of the syringe 1 is transferred in the vertical position, the lug 2 sets down. Trying to enter a metered volume of on-line calibration 9 liquid medicines, tightly closed with the cap 4 lugs 2 and 3. Before dosing and liquid medicines, the body of the syringe 1 is transferred in the vertical position, the lug 2 sets down, turn additional stock and risk at the end of the additional emphasis of the rod 16 is set to the "To" tag on the end of the stop rod 15. Open the gap between the seal 8 of the piston 7 and the body of the syringe 1, shift the piston 7 to the measured level, focusing on the line 11 connecting the main 9 and 10 additional line calibration. Turn additional shaft 6 to its original position and risk at the end of the focus additional rod 16 set against the provisions of the "P" tag at the end of the lock rod 15. Within 15 minutes fluid is E. the drug is mixed with a gaseous substance. Remove hermetically mounted cap 4 with tip 2, put on the needle, remove the gaseous mixture is not mixed with the liquid drug, by pressure on the end of the stop rod 13 and the end stops of additional displacement rod 14 of the piston 7 to the original measured level of liquid medicines on-line calibration.

Device for dispensing medicines works in the following way. The body of the syringe 1 have horizontally. An additional tip 3 come up. Remove tightly installed caps 4 with lugs 2 and 3. Turn additional rod 6, and the risk that at the end of the additional emphasis of the rod 16 is set to the "To" tag on the end of the stop rod 15, thus opening a gap between the body of the syringe 1 and the seal 8, which is located on the piston 7. By pressure on the end of the stop rod 13 and the additional rod 14 of the piston 7 moves to an extreme position near the tip 2. Introducing a metered amount of gaseous mixture. Risk on the additional end of the rod 16 will return to its original position "P" is a label on the end of the lock rod 15, thus closing the gap between the seal 8 of the piston 7 and the body of the syringe 1. The body of the syringe 1 is transferred in the vertical position, the lug 2 sets down. Trying to enter a metered volume of on-line calibration 9 LM the who medicines tightly close the caps 4 lugs 2 and 3. Before dosing and liquid medicines, the body of the syringe 1 is transferred in the vertical position, the lug 2 sets down. Turn additional stock and risk at the end of the additional emphasis of the rod 16 is set to the "To" tag on the end of the stop rod 15. Open the gap between the seal 8 of the piston 7 and the body of the syringe 1, shift the piston 7 to the measured level, focusing on the line 11 connecting the main 9 and 10 additional line calibration. Turn additional shaft 6 to its original position and risk at the end of the focus additional rod 16 set against the provisions of the "P" tag at the end of the lock rod 15. Within 15 minutes the liquid drug is mixed with a gaseous substance. Remove hermetically mounted cap 4 with tip 2, put on the needle, remove the gaseous mixture is not mixed with the liquid drug, by pressure on the end of the stop rod 13 and the end stops of additional displacement rod 14 of the piston 7 to the original measured level of liquid medicines on-line calibration. Before using the syringe to check for leaks (GOST 24861-91, s-15).

A specific example of the method.

Patient K., 35 years since the compression of the tibia prehospital the stage used the proposed method and device. The body of the syringe installed horizontally. An additional tip is positioned upward. Took hermetically installed caps on the tips. Turned additional stock and risk at the end of the focus additional rod installed in the position of the label "K" on the end of the stop rod, thus opened the gap between the body of the syringe and the seal placed on the piston. By pressure on the end of the lock rod, the piston is moved to an extreme position near the tip. Added a tip to the vessel filled with oxygen. In the cavity of the syringe has introduced a metered amount of gaseous substances. Risk at the end of the additional rod is returned to its original position "P" tag on the end of the stop rod, when it closed the gap between the sealing piston and the body of the syringe. The body of the syringe was transferred in the vertical position, the tip has set down. Scored a metered volume of liquid medicines on-line calibration. Tightly closed caps tips. The syringe was placed for transport to the Bix. At the scene pulled the syringe. Before dosing and liquid medicines, the body of the syringe was transferred in the vertical position, the tip has set down. Turned additional stock and risk at the end of the focus additional rod set in the position "K" - mark at the end of the KJV is and stem ie opened the gap between the sealing piston and the body of the syringe, moved the piston to the measured level, focusing on the connecting line between the basic and additional line calibration. Turned an additional rod to its original position and risk at the end of the focus of additional stock set against the provisions of the "P" tag on the end of the stop rod. Within 15 minutes the liquid drug is mixed with a gaseous substance. Took hermetically mounted cap with tip, put the needle, removed the gaseous mixture is not mixed with the liquid drug, by pressure on the end of the stop rod displacement of the piston to the initial dosage level of liquid medicines on-line calibration. Oxygenated perftoran was administered to the patient. (PO2=200 mm Hg)

The significance of differences between the proposed method and device is as follows.

You need to use dosage mixing liquid medicines with a gaseous mixture of, for example oxygendemanding of perftoran prehospital during ischemic injury. Tissue hypoxia leads to degeneration and necrosis of muscle tissue, and this contributes to the reproduction of micro-organisms, particularly anaerobic infection, and progression of sepsis (Aswathy, Writes, V.tsvetkov. Surgical tactics in which icenii syndrome long crushing, The doctor, 1996, No. 8, p.28-29). Perfluorocarbon emulsion dissolve in the lipids of cell membranes, carry in themselves the oxygen and carbon dioxide and become part of the transport system of oxygen in cells and tissues of the body. Incorporating into the structure of cell membranes, these emulsions are capable of stabilizing the structure of the endothelium of blood vessels and cell membranes (Whichmakes and others In kN.: "Performancesee compounds in biology and medicine". Pushchino, 1999, s-145).

The body of the syringe have horizontally extra tip up, as oxygen is introduced into the body cavity of the syringe through the tip and the gap between the sealing piston and the wall of the housing of the syringe, having a heavier specific gravity than air, will displace air through an additional tip is to stay inside the syringe.

The number of perftoran, dialed into the syringe depends on the situation, in which it will be used, the extent of tissue damage, but should not exceed 0.1-0.5 ml/kg of body weight (Patent RF №2237473 from 10.10.2004, bull. No. 28). Caps lugs set tightly.

Perftoran, introduced into the tissue at the prehospital stage, you must oxygenate. As in the military field conditions and emergency assistance to the miners in the mine having difficulty oxygenation of perftoran, the use of the facilities is imago method and device will be rational. For dosage oxygen therapy is used for line calibration on the body of the syringe. Given that the rational content PO2 of perftoran must match 190-210 mm Hg, experimentally found that for oxygenation of 5.0 ml of perftoran within 15 minutes of 1.88-2.00 ml of oxygen, 10.0 ml of perftoran need of 3.75 to 4.0 ml of oxygen for 15 ml of perftoran need 5,63 to 6.0 ml of oxygen. This relationship is marked by an extra line calibration, focusing on the connecting line between the basic and additional line calibration. It is intended to determine the necessary volume of gaseous substances dosed for mixing with the liquid drug.

The inventive method and device allows dosed to oxygenate perftoran prehospital. To activate blood circulation in the affected tissues oxygenated perftoran allows you to improve nutrition and respiration, to ease the development of ischemic edema, reduce the plasma loss and thickening of the blood, causing secondary circulatory hypoxia of the tissues around the wound, which leads to myonecrosis, Milito, toxemia, purulent-necrotic complications, and as in the tissues of large oxygen deficiency, may develop anaerobic infections. Sooner will be introduced oxygenated perft the wounds in pre-hospital stage in the affected tissue, the more opportunities to prevent reperfusion changes, prevention of complications and reduce mortality. With the aid, for example, with gunshot wounds, wounds caused by electric saw, wounds in ischemic tissues, such as long compressed, the early introduction of oxygendemanding of perftoran will reduce the severity of complications, improve quality of care, prevent complications. Reduced time and reduced treatment costs, and reduced level of disability when using the method and the device will give a significant economic effect.

1. Device for the metered mixing liquid medicines with gaseous substance, characterized in that it includes the body of the syringe with stop finger tip and located on the frame line calibration, situated inside a rod with a piston at one end and a stop on the other, located on the piston seal, the housing opposite to the tip end, near a stop for the fingers is made an additional tip, both tip sealed with removable caps, inside the stem, at the end of the fence which is made of a label, an additional rod with a focus on the end face of which is made of the risk, while additional stock is made with the possibility of the ability of rotation for opening and closing of the gap between the body of the syringe and the seal of the piston, on the body of the syringe near the line calibration caused additional line calibration, and the line connecting the primary and secondary line calibration, while between the body of the syringe and the piston rod on the opposite side from the tip of the installed o-ring.

2. The dosed method of mixing liquid medicines with gaseous substance, characterized in that the housing of the syringe device according to claim 1 have horizontally extra tip up, remove tightly installed caps on the primary and secondary nozzles, the rotation of the additional shaft to open the gap between the body of the syringe and the seal placed on the piston, and the piston is moved to an extreme position near the tip, through which introduce a metered amount of gaseous substances, additional stock return to its original position, the body of the syringe is transferred to the vertical position and place the tip down, trying to enter a metered amount of on-line calibration of liquid medicines, tightly closed with the cap main and for more tips, before use of liquid medicines, the body of the syringe is transferred to the vertical position of the tip down, the additional rotation of the stem to open the gap between uplo is the diameter of the piston and the body of the syringe, move the piston to the measured level, focusing on the connecting line between the basic and additional line calibration, return the additional rod to its original position, within 15 min of liquid drug is mixed with a gaseous substance, remove hermetically mounted cap with tip, put the needle, remove the gaseous substance is not mixed with the liquid drug, by shifting the piston to metered stamps on-line calibration of liquid medicines.

3. The method according to claim 2, characterized in that as liquid medicines with gas transport function use perftoran, and as a gaseous substance use oxygen.



 

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1 ex

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