Synergic fungicide composition, method for controlling of phytopathogenic fungi, product

FIELD: fungicides.

SUBSTANCE: invention relates to fungicide composition containing 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-benzamide (compound I) and mankozeb (compound II), and method for treatment or prophylaxis controlling of phytopathogenic fungi of agriculture cultures using the said composition. Product containing compound I and compound II in weight ratio of from 1/100 to 5/1 also is disclosed.

EFFECT: fungicide composition of high efficiency.

9 cl, 1 tbl, 1 ex

 

The present invention relates to combinations of antifungal compounds, intended, in particular, to protect crops from fungal diseases, and appropriate remedies by using combinations specified.

More specifically, an object of the present invention are new fungicidal compositions based on derivatives pyridylmethylamine and dithiocarbamate.

As for fungicidal activity, in particular for protection of agricultural crops, one of the problems in the art, which is currently intensively studied, is to increase the efficiency, in particular fungicidal activity, and, in particular, from the viewpoint of maintaining the specified fungicidal activity in a long time.

Naturally, fungicidal compounds, applicable for protection of plants against fungi, must have a minimum of Ecotoxicity. To the extent possible, they should not be hazardous or toxic to the operator during use.

In addition, fungicidal compounds preferably should possess a broad spectrum of action.

When you search for new antifungal compounds should not, of course, neglect and economic factor.

In the description of the present invention focuses on, however, this is not ogran is ensured, protection from fungal infection, in particular grapes, cereals, fruits, vegetables, alfalfa seed, soybean, commercial vegetable crops, turf, forest, garden plants, etc.

The composition according to the present invention includes one or more compounds of the type pyridylmethylamine having fungicidal activity, as described in European patent application EP-A-1056723. These compounds help prevent the growth and development of pathogenic fungi (e.g., compounds that are active in the treatment of downy mildew, for example, grapes, such as Plasmopara viticola).

In the referenced patent application EP-A-1056723 in General mentioned the possibility of combining these active fungicidal agents with compounds for which it is known that they exhibit fungicidal activity, but not the name given to the combined effect of the active ingredients and not even listed family together existing active ingredients that could be combined with pyridylmethylamine.

One of the essential purposes of the present invention is to solve the above problems.

One of the essential purposes of the present invention are new fungicidal compounds which may be used, for example, by farmers to control fungi that infect selskokhozyaistv is by culture and in particular, for the management of major fungal diseases of grapes, such as downy mildew.

Another essential objective of the present invention is a new fungicidal composition based derivatives pyridylmethylamine, which is significantly more active against fungi harmful to plants, including grapes, and which, in particular, active for longer periods of time than currently known antifungal agents.

Another essential objective of the present invention is a new antifungal agent that is highly effective, in particular against fungi, and which has a long performance, so it allows you to reduce the dose of chemical compounds, which are distributed in the environment to combat the attacks of fungi on crops, in particular to combat downy mildew of grapes.

Another essential objective of the present invention is a new fungicide composition, which is more active and has been active for a longer time, and therefore can be used in a smaller dose, and which is also less toxic.

Another essential objective of the present invention is a new fungicidal composition of broad steps, which is effective in the long the belts and which gives the farmer a large number of compounds, so he can choose among them the connection, the most suitable for a particular application.

Another essential objective of the present invention is a new fungicidal composition which satisfies the requirements specified in the above order, and which also has a lower price, easier to manufacture and is not dangerous to handle.

Another essential objective of the present invention is a new fungicidal composition defined in the above objectives and which is applicable for preventive and therapeutic measures against fungal diseases, such as grapes, grain crops, solanaceous plants, fruits, vegetables, alfalfa, soybeans, commercial vegetable crops, turf, forest and garden plants.

Another essential objective of the present invention is a prophylactic and/or therapeutic treatment of plants and, in particular, crops, using fungicidal fungicidal composition or combination, combining the compounds in the composition, which is defined in the above order, for a specified processing is important that it had a high and constant efficiency in relation to a very wide range of fungi and at the same time to minimize dose, toxicity, and cost.

Another essential aim of the infusion is his invention is set to fight - through treatment and/or prevention and/or destruction from phytopathogenic fungi of plants, particularly crops such as grapes, which meets the requirements listed in the above order.

Finally, another important aim of the present invention is to increase the output of crops that would be significant from the agronomic point of view.

All of these objectives, among others, have been achieved by the applicants, who managed to find a fungicidal combination derived pyridylmethylamine and connection type dithiocarbamato, mainly fungicide. This combination surprisingly and unexpectedly has a very high and prolonged antifungal efficacy against a broad spectrum of fungi and, in particular, to the fungi responsible for diseases such as downy mildew of grapes.

Thus, the present invention which completely or partially satisfies the above objectives, relates primarily to the fungicidal compositions, including:

a) at least one derivative pyridylmethylamine formula (I):

where

R1selected from a hydrogen atom, optionally substituted alkyl radical and optionally substituted acyl radical;

R2selected from a hydrogen atom and optionally substituted alkyl radical;

R3and R4that may be the same or different, is independently selected from a halogen atom, a hydroxyl radical, ceanography, nitro, radical-SF5, trialkylsilyl radical, optionally substituted amino, acyl radical and a group E, OE or SE, in which E is chosen from alkyl, altenloh, akinrinola, cycloalkyl, cycloalkenyl, aryl and heterocyclyl radical, each of them optionally may have substituents;

c represents 0, 1, 2, 3 or 4;

q denotes 0, 1, 2, 3 or 4;

and its agronomically acceptable possible optical and/or geometric isomers, tautomers and additive salts with an acid or a base;

and

b) at least one compound (II), which is selected from dithiocarbamates, and its agronomically acceptable isomers and additive salts with acid.

Different radicals and chemical terms used above in the definitions of the compounds of formula (I), unless specifically specified, have the following meanings:

"alkyl" denotes a linear or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms;

"alkenyl" denotes a linear or branched hydrocarbon radical having from 1 to 6 and the Ohm carbon unsaturation in the form of a double bond;

"quinil" denotes a linear or branched hydrocarbon radical having from 1 to 6 carbon atoms and an unsaturation in the form of a triple bond;

"alkoxy" refers to CNS radical;

"acyl" denotes a formyl radical or alkoxycarbonyl radical;

"cycloalkyl" denotes a saturated cyclic hydrocarbon radical having 3 to 8 carbon atoms;

"aryl" means phenyl or nattily radical;

"heterocyclyl" denotes an unsaturated or fully or partially saturated cyclic radical which has 3 to 8 atoms selected from carbon, nitrogen, sulfur and oxygen, for example, without limiting the present invention, - pyridyl, pyridinyl, hinely, furyl, thienyl, pyrrolyl, oxazolyl;

the term "optionally substituted" means that the named radicals can contain as substituents one or more radicals selected from chlorine, bromine, fluorine, iodine, alkyl, alkoxy, hydroxyl, nitro, amino, ceanography and acyl.

The compounds of formula (I) are described, for example, in patent application EP-A-1056723, and among them, preferred are the following:

connection with one of the following characteristics:

R1and R2that may be the same or different, is independently selected from a hydrogen atom or optional Zam is placed alkyl radical;

R3and R4that may be the same or different, is independently selected from a halogen atom, a hydroxyl radical, nitro, optionally substituted amino, acyl radical and a group E, OE or SE, in which E is chosen from alkyl, cycloalkyl, phenyl and heterocyclyl radical, each of them optionally may have substituents;

c represents 0, 1, 2 or 3;

q denotes 0, 1, 2 or 3;

and their agronomically acceptable possible optical and/or geometric isomers, tautomers and additive salts with an acid or a base.

Among the compounds of formula (I) preferred are also the following:

compounds with at least one of the following characteristics:

R1and R2that may be the same or different, is independently selected from a hydrogen atom and a methyl or ethyl radical;

R3and R4that may be the same or different, is independently selected from a halogen atom, nitro, optionally substituted amino, and alkyl, cycloalkyl, phenyl or heterocyclyl radical, each of them optionally may have substituents;

c denotes 1 or 2;

q denotes 1 or 2;

and their agronomically acceptable possible optical and/or geometric isomers, tautomers and add the active salt with acid or base.

More preferred compounds of formula (I) are the following:

compounds that have the following characteristics:

R1and R2each independently represents a hydrogen atom;

R3and R4that may be the same or different, is independently selected from a halogen atom, nitro, alkyl radical and triptorelin radical;

c and q independently of one another denote 2;

and their agronomically acceptable possible tautomers and additive salts with an acid or a base.

As an example, the most preferred compounds of formula (I) according to the present invention are the following:

the compound (Ia), which is a 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}benzamide;

the compound (Ib), which is N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-fluoro-6-nitrobenzamide;

the compound (Ic), which is N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-methyl-6-nitrobenzamide;

and their agronomically acceptable possible tautomers and additive salts with an acid or a base.

Compounds (II) are preferably dithiocarbamate known for their fungicidal activity, and their agronomically acceptable isomers and additive salts with acid.

Even more preferably antifungal dithiocarbamate the s (II) is chosen from the group of compounds includes: ferbam, marcopper, MANCOZEB, MANEB, metiram, nabam, bis(dimethyldithiocarbamate) Nickel, propineb, zineb and mixtures thereof.

The compositions of the present invention mainly contains:

the compound (Ia) and/or compound (Ib) and/or the compound (Ic) in combination with MANCOZEB or propineb.

Preferred compositions of the present invention include the compound (Ia) and MANCOZEB or propineb and possible tautomers and additive salt with acid or base compounds (Ia) and MANCOZEB or propineb, if these equivalents are agronomically acceptable.

In accordance with the invention, the fungicidal combination of compound (I) with compound (II), in particular with MANCOZEB or propineb, allows to considerably increase the resistance of the antifungal activity in therapeutic and/or preventive actions against major diseases of agricultural crops, including diseases caused by fungi of the family peronosporaceae fungi, in particular Plasmopara viticola (downy mildew of grapes), Plasmopara halstedei (downy mildew of sunflower), Pseudoperonospora sp (in particular, downy mildew of pumpkin (Pseudoperonospora cubensis) and downy mildew of hops (Pseudoperonospora humuli)), Bremia lactucae (downy mildew of lettuce), Peronospora. tabacinae (downy mildew of tobacco), Peronospora. destructor (downy mildew of onion), Pernospora parasitica (downy mildew of cabbage), Peronospora. farinosa (downy mildew of chicory and downy mildew of sugar beet).

In particular, this combination has the ability to destroy fungi, which exceeds the ability of each of the compounds alone.

It should be noted that in accordance with the present invention the weight ratio of compound (I) to the compound (II) is most often ranges from 1/500 to 30/1, preferably from 1/200 to 20/1, and more preferably from 1/10 to 10/1.

The ratio of compound (I)/compound (II) is defined as the weight ratio of these two compounds. The same is true for any ratio of two chemical compounds, the measurement of which is later in the text of the present description, unless otherwise specified.

In accordance with another aspect of the present invention in the compositions according to the invention the ratio of the compound (I)/compound (II) can preferably be chosen in such a way as to obtain a synergistic effect. The term synergistic effect see, in particular, the concept whose definition Colby results in an article entitled "Calculation of the synergistic and antagonistic responses of herbicide combinations" Weeds, (1967), 15, pages 20-22.

This article describes the formula:

in which E represents the expected percentage of inhibition of the disease for the combination of two fungicide is at the selected doses (for example, equal to x and y respectively), x denotes the percentage of inhibition observed for the disease by the action of compound (I) at the chosen dose (equal to x), y denotes the percentage of inhibition observed for the disease under the action of the compound (II) with the selected dose (equal to y). If the percentage of inhibition observed for the combination exceeds E, then there is a synergistic effect.

The term "synergistic effect" means an effect that is determined according to the method Tamsa described in "Isoboles, a graphic representation of synergism in pesticides", Netherlands Journal of Plant Pathology, 70 (1964), pages 73-80.

The above interval relations the compound (I)/compound (II) in no way limit the present invention, but rather are given for reference so that the person skilled in the art can conduct additional tests to establish other values relationships doses of these two compounds, in particular, such a relationship where there is a synergistic effect.

The ratio of compound (I)/compound (II) predominantly chosen so that to obtain a synergistic effect.

Typically, the compositions according to the invention contain the active compound in the range of from 0.00001 to 100%, mostly in the range of from 0.001 to 80%, regardless combine whether the connection or they are in the form of two active ingredients, which are used by the separate.

It should be understood that these fungicidal compositions may contain one compound (I) or more of such compounds and/or one compound (II) or more of such compounds and one or more other fungicide, herbicide, insecticide compounds and/or plant growth regulators, which are used in accordance with their purpose.

So, the fungicidal composition of the present invention may also contain, for example, one or more other fungicide active ingredients selected from acibenzolar-S-methyl, AZOXYSTROBIN, benalaxyl, benomyl, blasticidin-S, bromuconazole, captafol, Captan, carbendazim, carboxin, cropropamide, chlorthalonil, fungicidal compositions based on copper and derivatives of copper such as copper hydroxide and copper oxychloride, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, dichloran, dechlorinate, tietopankki, difenoconazole, diplomatarium, dimethomorph, dimoxystrobin, diniconazole, disastrous, datamorph, Dodin, edifenphos, epoxiconazole, ethaboxam, ethirimol, fenarimol, fenbuconazole, fenhexamid, Theoxenia, fenpiclonil, fenpropidin, fenpropimorph, persona, fluazinam, fludioxonil, flamethower, fluconazole, flusilazole, flosulide, flutolanil, flutriafol, fo who sang, paralexia, parameter, guazatine, hexaconazole, hymexazole, imazalil, iprobenfos, iprodione, isoprothiolane, kasugamycin, kresoxim-methyl, mefenoxam, mepanipyrim, metalaxyl and its enantiomeric forms, such as metalaxyl-M, metconazole, metiram-zinc, mecamylamine, metrafenone, nicobifen, oxadixyl, EXPOCONSTA, peyratout, penconazole, pencycuron, phosphoric acid and its derivatives, such as fosetyl-Al, phthalide, picoxystrobin, provenzale, prochloraz, procymidone, propamocarb, propiconazole, pyraclostrobin, Pyrimethanil, piroximone, jenoxifen, silthiofam, siliconate, spiroxamine, soup-190, tebuconazole, tetraconazole, thiabendazole, leflunamide, thiophanate, for example, thiophanate-methyl, Tirana, tadinya, triadimefon, triadimenol, tricyclazole, tridemorph, Trifloxystrobin, triticonazole, amide derivatives α-aminosalicilovoj acid, such as, for example, iprovalicarb, vinclozolin and zoxamide.

In addition to these additional active agents of the fungicidal compositions of the present invention may also contain other fillers and/or tools applicable to compositions for protecting plants, such as, for example, agronomically acceptable inert carrier and optionally agronomically acceptable surface-active in the society.

As for the forms of the compositions according to the invention, it should be noted that they are suitable for a large number of compounds. So, you can use the composition in the form of an aerosol disperser, poisoned traps (ready to use), a concentrate for the preparation of traps, tanks for pickup traps, suspensions, capsules, concentrate to produce a cold fog, dustbrush powder capable of forming an emulsion concentrate, emulsion type, the aqueous phase in the aqueous phase; an inverse emulsion; coated granules; very fine granules; suspension concentrate for mordant agent of seeds; compressed gas; emit gas connections; traps in the form of grain; traps in the form of granules; granules; concentrate for hot mist; microgranule; microspheres; dispersible in oil powder, concentrate mixed with oil suspension; mixing with the oil liquid; paste; vegetable sticks; traps in the form of plates; powder for dry mordant agent of seeds; traps in pieces; seed, potraviny pesticide; smoke bombs; smoke cartridge; smoke tablet; dynacorn; soluble concentrate, soluble powder, solution for seed treatment, suspension concentrate (= flowable concentrate); powder for forming tracks fluids for ultra-low volume spraying; suspen the AI for ultra-low volume spraying; allocating a pair of connections; dispersible in water granules or tablets; dispersible in water powder for suspension; water-soluble granules or tablets, water-soluble powder for mordant agent of seeds; wettable powder.

These songs encompass not only the composition ready for application to crops that need to be processed using a suitable tool, such as a sprayer, but also to the manufactured compositions in the form of concentrates which must be diluted before processing crops.

The following compositions are used generally for the treatment of growing plants or their habitats, or for mordant agent of seeds or thin film deposition on the seed.

The composition according to the invention, respectively, are applied to plants and, in particular, to sheets that are affected or may be affected by phytopathogenic fungi. Another method of using compounds or compositions of the present invention consists of adding to the composition containing the active ingredients to water for irrigation. This irrigation can be carried out using a sprinkler.

For the practical application of the compositions of the present invention can be used independently, and also preferably may be used in order to find in the form of compositions, containing a particular active ingredient, or alternatively, both of them simultaneously in combination or in combination with one or more compatible components that, for example, are solid or liquid fillers or diluents, excipients, surfactants, or their equivalent compounds, which are suitable for the desired application and are acceptable for use in Agrochemistry. The compositions can be any known type of compositions known in the art which are suitable for use in all types of plants or crops. These compositions, which can be obtained by any known from the field of engineering methods, are also part of the present invention.

The compositions can also contain other ingredients such as protective colloids, binders, adhesives, thickeners, thixotropic agents, wetting, oils for spraying, stabilizers, preservatives (in particular, agents that protect against mold), passivator, etc. as well as other active ingredients, which have pesticidal properties (in particular, fungicidal, insecticidal, acaricidal or nematocidal properties) or which have the ability to regulate the growth of plants. In the General case, connect the means of the present invention can be combined with any solid or liquid additives, typically used in methods of manufacturing compositions.

In the present invention, the term "filler" means organic or inorganic, natural or synthetic compound with which the active ingredients are combined in order to facilitate their application, for example, on plants, seeds or soil. Thus, the filler is generally inert and should be acceptable (for example, acceptable for use in agriculture, in particular, to processing plants).

The filler may be a solid, such as clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers (e.g. ammonium salts), natural minerals that are included in the composition of the soil, such as kaolins, clays, talc, lime, quartz, attapulgite, montmorillonite, bentonite or diatomaceous earth, or synthetic minerals, such as silica, alumina or silicates, in particular, silicates of aluminum or magnesium. Solid fillers which are suitable for producing granules, are the following: natural, crushed or crushed rocks such as calcite, marble, pumice, thick and dolomite; synthetic granules obtained from flour inorganic or organic compounds; granules of organic material such as sawdust, coconut shell is, ears or husk of corn or tobacco stems; kieselguhr, tricalcium phosphate, the bark of the cork oak in the form of a powder or an adsorbent in the form of gaseous carbon black; water-soluble polymers, resins, waxes; and solid fertilizers. Such compositions, if necessary, may contain one or more compatible agents such as wetting, dispersing agents, emulsifying agents, or coloring matter, which, if they are solids, can play the role of diluents.

Fillers may also be liquid, for example, water, alcohols, in particular butanol or glycol as well as their complex and ethers, in particular, methylsiliconate; ketones, in particular acetone, cyclohexanone, methyl ethyl ketone, isobutyl ketone or isophorone; fraction distillation of crude oil such as paraffinic or aromatic hydrocarbons, particularly xylenes or alkylnaphthalene; mineral or vegetable oils; aliphatic chlorinated hydrocarbons, in particular, trichlorethane or methylene chloride; aromatic chlorinated hydrocarbons, in particular, chlorobenzene; water-soluble or strongly polar solvents, such as dimethylformamide, dimethylsulfoxide, N,N-dimethylacetamide or N-organic N-octylpyrimidine, liquefied gases; and so, if e is ω, they can be used individually and in the composition of the mixture.

Surfactant can be an emulsifier, dispersant or wetting agent of ionic or nonionic type, or may be a mixture of these surfactants. Of these surface-active substances used are, for example, salts of polyacrylic acids, salts of lignosulfonate, salt phenolsulfonate or naphthalenesulfonate, the polycondensation products of ethylene oxide with fatty alcohols or fatty acids or fatty esters or fatty amines, substituted phenols (in particular ALKYLPHENOLS or kilfenora), salts of esters sulfonterol acid derivative aminoethanesulfonic (in particular, alliterate), esters of alcohols with phosphoric acid or polycondensation products of ethylene oxide with phenols, esters of fatty acids with polyols or sulphate, sulphonate or phosphate functional derivatives of the above compounds. The presence of at least one surfactant is important in the case when the active ingredients and/or inert filler is insoluble or only partially soluble in water, and in the case when as a filler to the above composition, water should be used.

The compositions of the present invention may also contain other d is the additives, such as binders or dyes. The compositions can be used binder such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules, or matrix, such as gum Arabic, latex, polyvinylpyrrolidone, polyvinyl alcohol or polyvinyl acetate, natural phospholipids, such as capalini or lecithins, and synthetic phospholipids. It is possible to use colorants such as inorganic pigments, e.g. iron oxide, titanium oxide, Prussian blue; organic dyes, such as dyes of the type of alizarin, azo-dyes or metallophthalocyanines; or trace elements such as salts of iron, manganese, boron, copper, cobalt, molybdenum or zinc.

Formulations containing the compositions of the present invention, which are used for combating phytopathogenic fungi of plants may also contain stabilizers, other antifungal agents, insecticides, acaricides, nematicides, antihelmintic or anticoccidials, bactericides, attractants or repellents, deodorants, perfume or dyes.

You can choose to increase strength, increase duration of action, increased security, or broaden the spectrum of action against phytopathogenic fungi of plants or so that the composition can perform other useful functions for processing tihamah surfaces.

For application to leaves the choice of surfactant is critical to ensure good bioavailability of the active ingredients; thus, it is preferable to use a combination of hydrophilic surfactant (hydrophilic-lipophilic balance >10) and lipophilic surfactant (hydrophilic-lipophilic balance <5). This combination of surface-active substances, for example, described in patent application France No. 00 04015.

As to obtain the compounds (I), it is possible to refer to European patent application EP-A-1056723.

With regard to the preparation of compounds (II), we can refer to the book "the Electronic Pesticide Manual - Version 1.0", the British Crop Protection Council Ed. Clive Tomlin.

In accordance with another objective of the present invention it relates to a method of struggle - through treatment, prevention, or destruction from phytopathogenic fungi of crops, characterized in that an effective (agronomically effective) and neotomine number above fungicidal compositions are applied to the soil where they grow or can grow plants, leaves and/or fruits of plants or plant seeds.

At the specified method using the composition, which is prepared in advance by mixing the two active compounds (I) and (II).

In accordance with Rasnov what bullying; appropriate this method of struggle - through treatment, prevention, or destruction from phytopathogenic fungi of plants:

- use a combination of the above at least one compound (I) and at least one compound (II);

the compound (I) and (II) simultaneously, separately or sequentially applied to the soil where they grow or can grow plants, leaves and/or fruits of plants or plant seeds in an effective (agronomically effective) and nepatologickou number.

This variant embodiment of the invention refers to the use of freshly prepared fungicidal composition.

Order to obtain the combined effect of the use of the compounds (I)/(II) can also simultaneously, separately or sequentially apply the composition, each of which contains one of the two active ingredients (I) or (II).

The fungicidal composition of the present invention is usually preferably contains from 0.5 to 95% of the combinations of the compound (I) and compound (II). It can represent a concentrated composition, i.e. the product, combining compound (I) and the compound (II). It can also be a diluted composition ready for application to the treated plants. In the latter case, the dilution water can be enjoyed with the use of the prepared concentrated compositions, sod is Rasa compound (I) and the compound (II) (ready mix), and mixing in the tank two ready concentrated compositions, each of which contains the compound (I) and the compound (II).

Processing plants defeat against phytopathogens using the fungicidal compositions of the present invention is conducted, for example, by applying or introducing effective and revitalising number above fungicidal composition or combination of the above-ground parts of plants or to the soil where they grow, these plants are affected or may be affected by phytopathogenic diseases, such as downy mildew, powdery mildew, brown rust or Septoria. It should also be understood that the expression "processing plant" includes processing the reproduction of plants, such as seeds or tubers.

In certain conditions, for example, with regard to the type of destroying pathogenic fungi, adequate protection may require the use of smaller doses. On the contrary, certain climatic conditions, resistance or other factors may require larger doses of the active ingredients.

Effective working-dose combinations in accordance with the present invention can vary within wide proportions, in particular, depending on, for example, the type disposable phytopathogenic fungus or CTE is Yeni destruction of plants specified by the fungus.

The optimal dose is usually depends on several factors, for example, of the type subjected to the treatment of phytopathogenic fungus, type and phase of development of the affected plants, density of vegetation, or the method of application. The preferred effective dose of the active ingredients (I) and (II) is in the range from 7 g/ha to approximately 10,000 g/ha

In accordance with the present invention crops that are treated with the fungicidal composition or combination may be, without limiting the present invention, crops, however, these cultures can also be grapes, vegetables, fruit, alfalfa, soybean, commodity crops, turf, wood, or ornamental plants.

Phytopathogenic fungi infecting crops that can be controlled using the above method, is chosen from the group including:

the group of the oomycetes:

family peronosporaceae, in particular Plasmopara viticola (downy mildew of grapes), Plasmopara halstedei (powdery mildew of sunflower), Pseudoperonospora sp (in particular, powdery mildew of pumpkin (Pseudoperonospora cubensis) and powdery mildew of hops (Pseudoperonospora humuli)), Bremia lactucae (downy mildew of lettuce), Peronospora. tabacinae (downy mildew of tobacco), Peronospora. destructor (downy mildew of onion), Peronospora. parasitica (downy mildew of cabbage), Peronospora. farinosa (downy mildew of chicory and the light is lemichnyh);

- the genus Phytophthora, such as Phytophthora phaseoli, Phytophthora citrophthora, Phytophthora capsici, Phytophthora cactorum, Phytophthora palmivora, Phytophthora cinnamoni, Phytophthora megasperma, Phytophthora parasitica, Phytophthora fragariae, Phytophthora cryptogea, Phytophthora porri, Phytophthora nicotianae, Phytophthora infestans (powdery mildew Solanaceae, in particular, late blight of potato or tomato);

group adelomelon (records of Ascomycetes):

genus Alternaria, for example, Alternaria solani (early blight Solanaceae and, in particular, potato and tomato),

- the genus Guignardia, for example, Guignardia bidwelli (black rot),

- the genus Venturia, in particular, Venturia inaequalis, Venturia pirina (scab of Apple or pear),

- the genus Oidium, for example, powdery mildew of grape (Uncinula necator), powdery mildew of legumes, for example, Erysiphe polygoni (powdery mildew of crucifers); Leveillula taurica, Erysiphe cichoracearum, Sphaerotheca fuligena (powdery mildew of pumpkin, Compositae and tomatoes); Erysiphe communis (powdery mildew of sugar beet and cabbage); Erysiphe pisi (powdery mildew of pea and alfalfa); Erysiphe polyphaga (powdery mildew of beans and cucumber); Erysiphe umbelliferarum (powdery mildew of plants of family ombellifera, in particular carrots); Sphaerotheca humuli (downy mildew of hops); powdery mildew of wheat and barley (Erysiphe graminis forma specie tritici and Erysiphe graminis forma specie hordei),

- the genus Taphrina, for example, Taphrina deformans (crinkle leaf peach),

- the genus Septoria, for example, Septoria nodorum or Septoria tritici (Septoria the HLA is different cereals),

- the genus Sclerotinia, for example, Sclerotinia sclerotinium,

- the genus Pseudocercosporella, for example, P.herpotrichoides (ocellar spot of cereals),

- the genus Botrytis cinerea (grapes, vegetables and commercial crops, peas, etc.),

- the genus Phomopsis viticola (Ascaris grapes),

- rod Pyrenospora,

- the genus Helminthosporium, for example, Helminthosporium tritici repentis (yellow spot of wheat) or Helminthosporium teres (yellow blotch of barley),

- kind of Cereals or Pyrenophora,

a group of basidiomycetes:

- the genus Puccinia, for example, Puccinia recondita or striiformis (wheat rust), Puccinia triticina, Puccinia hordei,

- genus Rhizoctonia spp, for example, Rhizoctonia solani.

In addition to their fungicidal activity, which is the essence of the present invention, the above composition, or combination may also have biocidal activity against bacteria and viruses, such as, for example:

- bacterial blight of fruit trees, Erwinia amylovora;

bacterial streak stone fruit trees, Xanthomonas campestris;

- vertex pear blight, Pseudomonas syringae;

- bacteriosis of rice and cereals;

viruses present on rice, vegetables and cereals.

Cultures that are considered in the context of the present invention, preferably are grapes, cereal crops (wheat, barley, maize, rice) and vegetable crops (beans, onions, pumpkin, cabbage, potatoes, tomatoes, sweet pepper, the pinats, peas, lettuce, celery, chicory), fruit crops (strawberries, raspberries), cultural trees (Apple, pear, cherry, ginseng, lemon, coconut palms, trees, walnut, pecans, cacao trees, walnut trees, rubber trees, olive trees, poplars, bananas, sunflower, sugar beet, tobacco, hops and ornamental crops.

Classification, which is not based on the fungi or bacteria targeted by the effect of the compositions, and the cultures that they protect, can be illustrated as follows:

- grapes: downy mildew (Plasmopara viticola), powdery mildew (Uncinula necator), grey mould (Botrytis cinerea), Ascaris (Phomopsis viticola) and black root rot (Guignardia bidwelli),

- Solanaceae: rot (Phytophthora infestans), early blight (Alternaria solani) and grey mould (Botrytis cinerea),

- vegetable crops: downy mildew (Peronospora. sp., Bremia lactucae, Pseudoperonospora sp), Alternaria (Alternaria sp.), Sclerotinia (Sclerotinia sp.), gray mold (Botrytis cinerea), root collar rot or root rot (Rhizoctonia spp.), powdery mildew (Erysiphe sp.; Sphaerotheca fuliginea),

- driverslicense: scab (Venturia inaequalis, V. pirina), caused by bacteria of the disease (erwinia amylovora, xanthomonas campestris, pseudomonas syringae), powdery mildew (Podosphaera leucotricha) and rot (Monilia fructigena),

- citrus: scab (Elsinoe fawcetti), melanosis (Phomopsis citri) and diseases caused by Phytophthora sp.

- wheat, in part struggle with the following diseases seed: Fusarium blight (Microdochium nivale and Fusarium roseum), smut fungus Tilletia caries, Tilletia controversa or Tilletia indica), Septoria leaf blotch (Septoria nodorum),

- wheat, in part struggle with the following diseases of the aerial parts: eye spot (Pseudocercosporella herpotrichondes), rot (Gaeumannomyces graminis), Fusarium root collar rot (F. culmorum, F. frost), black scurf (Rhizoctonia cerealis), powdery mildew (Erysiphe graminis forma specie tritici), rust fungi (Puccinia striiformis and Puccinia recondita), Septoria leaf blotch (Septoria tritici and Septoria nodorum) and yellow leaf spot in wheat (Helminthosporium tritici-vulgaris),

- wheat and barley, in fighting bacterial and viral diseases such as yellow mosaic barley,

- barley, in part struggle with the following diseases seed: yellow leaf spot (Pyrenophora graminea, Bipolaris, Pyrenophora teres and Cochliobolus sativus), loose smut (Ustilago nuda) and Fusarium blight (Microdochium nivale and Fusarium roseum),

- barley, in part struggle with the following diseases of the aerial parts: eye spot (Pseudocercosporella herpotrichondes), yellow leaf spot (Pyrenophora teres and Cochliobolis sativus), powdery mildew (Erysiphe graminis forma specie hordei), dwarfism leaf (Puccinia hordei) and leaf blotch (Rhynchosporium secalis);

- potatoes, in terms of disease control tubers (in particular, Helminthosporium solani, Phoma tuberosa, Rhizoctonia solani, Fusarium solani) and some in the originate diseases (virus Y);

- cotton, part of the struggle with the following diseases of young plants obtained from seeds: black leg and neck rot (Rhizoctonia solani, Fusarium oxysporum), and black root collar rot (Thielaviopsis basicola),

- peas, in part struggle with the following diseases seed: Anthracnose (Ascochyta pisi, Mycosphaerella pinodes), Fusarium root rot (Fusarium oxysporum), grey mould (Botrytis cinerea), rust (Uromyces pisi),

- rape, in part struggle with the following diseases seed: Phoma lingam and Alternaria brassicae, gray mold (Botrytis cinerea) and Sclerotinia (Sclerotinia sclerotinium),

corn, in terms of disease control seeds (Rhizopus sp., Penicillium sp., Trichoderma sp., Aspergillus sp. and Gibberella fujikuron), yellow leaf spot (Bipolaris), Fusarium root rot (Fusarium oxysporum),

- rice: rot root collar or root rot (Rhizoctonia spp.),

- flax, in terms of disease control seeds (Alternaria linicola),

bananas: frogeye leaf spot (Mycosphaerella figiensis),

- turf: rust, powdery mildew, yellow leaf spot, terrorbyte (terruric) disease (Microdochium nivale, Pythium sp., Rhizoctonia solani, Sclerotinia homeocarpa),

- forest trees, in part struggle with black leg (Fusarium oxysporum, Rhizoctonia solani).

Very well, that a method of combating plant diseases of the present invention shows the best results against diseases of grape downy mildew (Plasmopara viticola), powdery mildew (Uncinula necator), grey mold (Botrytis cinerea), Escoriaza (Phomopsis viticola) and black rot (Guignardia bidweli) and diseases of vegetable crops.

The expression "put on cultivated plants" in this description means that the fungicidal compositions, which are the aim of the present invention can be deposited using various processing techniques, such as:

- spraying the aerial parts of these plants liquid containing one of these songs,

- testirovanie, soil granules or powders, spraying around these plants and, in the case of trees, the injection and plastering,

- stain seeds or coating film on the seeds of these plants with protective mixtures containing one of the specified compositions.

Spraying liquid from the aerial parts of cultivated crops is the preferred method of treatment.

The object of the present invention is also a product containing the compound (I) and the compound (II) in the form of a combined composition for simultaneous, separate or sequential use for the control of phytopathogenic fungi of crops in the place of their growth.

Another object of the present invention, which relates to a method of preparing compositions of the present invention immediately before its use, is set to fight, for therapeutic or prophylactic uses, with phytopathogenic fungi agricultural techniques the state of the crops, characterized in that it comprises at least one compound (I) and at least one compound (II), mentioned previously, which are expected to be combined or used simultaneously, separately or sequentially, with the aim of combating phytopathogenic fungi of crops in the place of their growth.

Thus, manufacture of packaging, where the user finds all the ingredients for the preparation of fungicidal composition which the user intends to use for crops. These ingredients, which include, in particular, the active agents (I) and (II) and which are packaged separately, shipped, for example, in the form of powder or in the form of more or less concentrated liquid. The user needs only to hold the mixture in accordance with the prescribed dose and add the desired amount of liquid, such as water, necessary to obtain the ready to use compositions that can be applied to protect crops.

Is the best product for simultaneous, separate, alternating or sequential application of at least one fungicidal compound (I) and one fungicidal compound (II).

Needless to say that various options that may be considered for compositions and methods for the present and the finding, are an integral part of the present invention; moreover, you can join or a combination of these various options with each other, which does not retreat from meaning or beyond the scope of this invention.

Similarly, just discussed various aspects of the present invention may be merged or combined with each other, and it does not retreat from meaning or beyond the scope of this invention.

The following example is provided merely to illustrate the present invention and in no way, it has no limit.

Example

The authors intend to illustrate the effectiveness of the compositions according to the invention on the example of the disease of grapes, in particular, combinations that combine the compound (I)having the chemical name 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}benzamide, and the compound (II), representing MANCOZEB in the form of a composition 85WP.

1 - Conditions and goals

The experiments involve within 24 hours of medical tests on grapes, infected Plasmopara viticola.

2 - Materials and methods

Technique:

Grape plants (cultivar Chardonnay) grown on a sandy soil in plastic pots, one plant per pot. Plants at the age of two months (stage 6 to 7 leaves) inoculant by spraying water suspe the Zia of sporocytes Plasmopara viticola, obtained from infected leaves. The concentration of sporocytes approximately 100,000 units/ml

After infection the treatment of inoculated plants by spraying only the compound (I) and compound (II) and a mixture of compounds (I) and compound (II), in each case, the applied dose is 500 l/ha

Investigated the ratio of the compound(I)/compound (II) are shown below in table 1.

After infection and treatment plants collect and leave for six days at a temperature of 20°C.

Then determine the degree of infection on a scale from 1 to 10, in which 0 indicates the absence of infection, and 10 represents 100%level of infection.

The percentage of control of the disease (efficiency: see below) calculated for each treatment relative not exposed to processing plants, and the expected results were evaluated using the Colby formula (see below).

Difference between actual results and expected results are used to determine the synergy between the two antifungal compounds in the compositions of the present invention.

Processing efficiency is calculated using the following Abbott's formula:

Analysis of results is carried out with the use of the model Colby:

in which E represents the expected percentage of inhibition of the disease for a combination of two fungicides at selected doses (for example equal to x and y respectively), x denotes the percentage of inhibition observed for the disease by the action of compound (I) at the chosen dose (equal to x), y denotes the percentage of inhibition observed for the disease under the action of the compound (II) with the selected dose (equal to y). If the percentage of inhibition observed for the combination exceeds E, is a synergistic effect.

The results:

The composition of the invention containing the compound (Ia) and MANCOZEB as compound (II), when the values of the ratio (I)/(II)is from 1/5 to 1/100, have a strong synergistic effect.

Table 1
Processing 1Level (ppm)Treatment 2Level (ppm)Percent efficiencyThe obtained resultsThe percentage synergistic effect
The compound (Ia)5//65,7//
1//58,2 //
0,1//11,9//
MANCOZEB25//17,2//
10//5,2//
1//23,1//
The compound (Ia)5MANCOZEB2584,071,6+12,4
5176,973,9+3
0,11032,816,5+16,3

1. Synergistic fungicidal composition comprising 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}benzamide(compound (I)) and MANCOZEB (compound (II)).

2. The fungicidal composition according to claim 1, characterized in that the ratio of compound (I)/compound (II) is from 1/100 to 1/5.

3. The fungicidal composition according to claim 1, characterized in that in addition to the compounds (I) and (II) it contains agronomically acceptable inert carrier and, if the need is and agronomically acceptable surfactant.

4. The fungicidal composition according to claim 1, characterized in that it contains from 0.00001 to 100%, mostly in the range of from 0.001 to 80%, the combination of compound (I) and compound (II).

5. Way to fight for therapeutic or prophylactic purposes with phytopathogenic fungi of crops, characterized in that an effective (agronomically effective) and neotomine amount of a fungicidal composition according to any one of claims 1 to 4 is applied on the soil where they grow or can grow plants, leaves and/or fruits of plants or plant seeds.

6. The method according to claim 5, wherein the fungicidal composition is applied by spraying on the aerial parts of cultivated agricultural crops.

7. The method according to claim 5 or 6, characterized in that the amount of the fungicidal composition corresponds to a dose of compound (I) and compound (II) in the range from about 1 g/ha to approximately 10,000 g/ha

8. The method according to claim 5, characterized in that culture, which is subjected to processing, choose from grapes, cereal crops (wheat, barley, maize, rice) and vegetable crops (beans, onions, pumpkin, cabbage, potato, tomato, sweet peppers, spinach, peas, lettuce, celery, chicory), fruit crops (strawberry, raspberry), cultural trees (apples, pears, cherries, wives who shenja, lemon trees, coconut trees, tree nuts pecans, cacao trees, walnut trees, rubber trees, olive trees, poplars, bananas, sunflower, sugar beet, tobacco, hops and ornamentals.

9. The product containing the compound of formula (I) and the compound of formula (II) in a weight ratio of from 1/100 to 5/1 in the form of a combined composition for simultaneous, separate or sequential use for the control of phytopathogenic fungi of crops in the place of their growth.



 

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