Method of production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon

FIELD: chemical industry; new method of production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon.

SUBSTANCE: the invention is pertaining to the new method of production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon, which one has the wide application as the semi-finished product in chemistry of organic synthesis, for example at production of the linear poly(phenylene oxides). The method consists in production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon in one container and provides for interaction of phenol with the brominating substance consisting of the mixture of the alkaline metal /alkaline earth metal bromide and the alkaline metal /alkaline earth metal bromate soluted in the deionized water at presence of the acid, extraction, washing and drying of the deposit with production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon. The technical result of the invention is simplification of the production process due to usage of phenol as the original substance and the combination of the alkaline metal /alkaline earth metal bromides and the alkaline metal /alkaline earth metal bromates.

EFFECT: the invention ensures simplification of the production process due to usage of phenol as the original substance and the combination of the alkaline metal /alkaline earth metal bromides and the alkaline metal /alkaline earth metal bromates.

15 cl, 4 ex

 

The invention relates to a method for in one capacity 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

Background of invention

2,4,4,6-Tetrabromo-2,5-cyclohexadienone has wide application in the chemistry of organic synthesis. It is used for obtaining a linear poly(phenylisoxazol) (W. Ried et al. Angew. Chem. Int., Ed. Engl. 8, 379, 1969), direct monobromobimane of imidazoles and N-methylindole (V. Calo et al. J. Chem. Soc., Perkin Trans. -1, 2567, 1972); stereoselective monobromobimane aromatic amines with the formation of 4-bromoaniline high yield (V. Calo et al. J. Chem. Soc. C, 3652, 1971); para-bromirovanii phenols by regioselective the synthesized phenols (V. Calo et al. J. Chem. Ind. (Milan), 53. 467, 1971); for the synthesized of thiophenol (c. Slemon US Patent 5371240; CA 1995, 122, 132966); to get α,β-unsaturated bromoethanol (V. Calo et al. Tetrahedron 29, 1625, 1973); for the reaction ring extensions (M. Lanz et al. Helv. Chem. Acta 80, 804, 1997); to obtain the brominated algal components synthesized by myrcene (T. Yoshihara et al. Bull. Chem. Soc. Jpn. 51, 653, 1978); for a direct romirowsky cyclization (T. Kato et al. Bioorg. Chem. 4, 188, 1975); for the synthesis of carbocyclic molecules (I. Ichinose et al. Chem. Lett. 61, 1979); receipt of polyene brominated and brominated dehydrohalogenation (Jpn. Kokai Tokkyo Koho 78, 112, 852; CA 1979, 90, 87701); if managed stereocenters dogsleding of tetrahydrofurane (P.C. Ting et al., J. Am. Chem. Soc. 106, 2668, 1984), and oxidative sin is ESA disulfides (T.L. Ho et al. Synthesis 872, 1974); intramolecular cyclization of phenolic Akimov as the final stage of synthesis of CIS,CIS-serotinin (A.R. Forrestewr et al. Justus Liebigs Ann. Chem. 66, 1978); for the synthesis of 6-bragantina and 9-bromoanthracene (T. Onishi et al. Jpn. Kokai Tokkyo Koho JP 60 181 037; CA 1986, 104, 110003); in the form of a combination of reagents for the conversion of alcohols to azides (A. Tanaka et al. Tetrahedron Lett. 38, 3955, 1997), silylation were synthesized in (A. Tanaka et al. Tetrahedron Lett. 38, 7223, 1997) and tetrahydropyranyl were synthesized in (A. Tanaka et al. Tetrahedron Lett. 38, 1955, 1997); with some General syntheses (B.M.Trost et al. J. Am. Chem. Soc. 105, 5075, 1983; T. Kato et al. J. Chem. Soc., Chem. Commun. 1077, 1984; F.E. Ziegler et al. J. Am. Chem. Soc. 112, 2749, 1990; K. Tatsuta et al. Bull. Chem. Soc. Jpn. 70, 427, 1997; K. Tatsuta et al. Pure Appl. Chem., 68, 1341, 1996; N.D. Pearson et al. Tetrahedron Lett., 35, 3771, 1994; G. Mehta et al. J. Chem. Soc., Chem. Commun. 1319, 1986; D. Yang et al. J. Am. Chem. Soc. 120, 5943, 1998; I.C. Gonzalez et al. J. Am. Chem. Soc. 122, 9099, 2000); for the allyl synthesized β-lactam antibiotics (Jpn. Kokai Tokkyo Koho JP 59 88,489; CA 1984, 101, 170973) and as a sensitizer for photooxidative of dioxano (L. Lopez et al. J. Chem. Soc., Chem. Commun. 1266, 1984 and Photochem. 32, 95, 1986).

Reference is made to M. Tsubota et al. (Bull. Chem. Soc. Jpn. 45, 1252, 1972), in which the bromination of 2,4,6-tribromophenol were made using liquid bromine. In this method, 50 mmol (8 g) of bromine was added to 37.2 mmol (12.3 g) of 2,4,6-tribromophenol at 2-3°in methanol-acetic acid 1:1 (V/V). The yellow precipitate of the desired product was obtained by adding 50 ml of 10% aqueous solution of the carbonate is sodium to the reaction mixture. The output of the non-crystalline product with a melting point equal to 136°With, was 90% (15 g of 36.5 mmol).

The disadvantage of this method is that the necessary manipulation and reaction with hazardous liquid bromine. With this method the necessary stage of neutralization of acetic acid with sodium carbonate after completion of the reaction. Also required additional stages for the separation of methanol and sodium acetate from waste for safe reset and in order to make this method more economically viable, and thus, the method is costly. In addition, the reaction should be conducted at low temperature, to require a special cooling device, which affects the cost of production. Moreover, this method begins with tribromophenol, i.e. the brominated phenol as a raw material. In addition, with this method stands out Hydrobromic acid as a by-product that requires sodium carbonate to neutralize it, along with acetic acid. The total number of bromine, passed in the final reaction product, is usually not more than 50%. In addition, the output is only 90%.

V. Calo et al. (J. Chem. Soc. C. 3652, 1971) and G.J. Fox et al. (Org. Synth. Coll. Vol. VI 181, 1988) have described the way the synthesized 2,4,6-tribromophenol using liquid bromine. In this method, the bromine and 2,4,6-Tr is Bromphenol reacted in equimolar ratio in a mixture of sodium acetate and acetic acid at room temperature. The reaction mixture was poured into crushed ice with a yellow precipitate 2,4,4,6-tetrabromo-2,5-cyclohexadienone. The crude product was dissolved in warm chloroform and allowed to crystallize while cooling with access 61-67% of the product having a melting point in the range of 125-130°C.

The disadvantages of this method is that it still exist manipulation with hazardous liquid bromine and requires special equipment. In addition, 50% of liquid bromine in the end is the exhaust flow in the form of Hydrobromic acid. Drains are dangerous because they contain sodium acetate, acetic acid and Hydrobromic acid, require additional stages, such as neutralization and separation for safe reset, which greatly increases the cost of production.

The purpose of the invention

The main purpose of this invention to provide an improved method for the synthesis in one capacity 2,4,4,6-tetrabromo-2,5-cyclohexadienone, which is free from the above disadvantages.

Another purpose of this invention is to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone by direct synthesized phenol.

Another objective of this invention is to use a combination of bromides of the alkali metal/alkaline earth metal and bromato alkali metal/lachnosterna metal as brainwashes reagent.

Another objective of this invention is the use of mineral acids or moderately strong organic acids as one of the reactants.

Another purpose of this invention to provide a 2,4,4,6-tetrabromo-2,5-cyclohexadienone at ambient temperature.

Another purpose of this invention is to maximize the use of bromine atoms in the reaction.

Another purpose of this invention is to minimize contaminants in the produced wastewater.

Summary of invention

Accordingly, this invention provides a method of obtaining in one capacity 2,4,4,6-tetrabromo-2,5-cyclohexadienone by the reaction of phenol with brainwashin means consisting of a mixture of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in deionized water, in the presence of acid, separation, washing and drying the precipitate to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

In another implementation of this invention the organic acid is selected from the group consisting of oxalic acid and citric acid.

In one of the embodiments of the present invention, the acid includes hydrochloric acid.

In another embodiment of the present invention is used, the phenol is phenol laboratory is largely purity.

In another embodiment of the present invention the method includes the reaction of 2-10 g (21-106 mmol) of phenol with a mixture 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth metal dissolved in 30 (weight/weight) equivalents of deionized water by slowly adding a 3.5-16.0 g (96-438 mmol) of 36% hydrochloric acid 5 (weight/weight) equivalents of deionized water for two hours, giving you the ability to proceed the reaction, filtering off the precipitate, washing and drying under vacuum to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

In another embodiment of the present invention the method comprises the slow addition of a solution 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth metal dissolved in 15 (weight/weight) equivalents of deionized water, to a mixture of 2-10 g (21-106 mmol) of phenol and 3,5-16.0 g (96-438 mmol) of 36% hydrochloric acid 20 (weight/weight) equivalents of deionized water for two hours; continue stirring for two hours, filtering off the precipitate, washing and drying to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

In yet another embodiment of the present invention the method comprises simultaneously adding 87-436 mmol moderately strong organic acid, dissolved in 5 (weight/weight) equivalents of water to the mixture of phenol, bromine is Yes alkaline/alkaline earth metal bromate alkali/alkaline earth metal 30 (weight/weight) equivalents of water; enabling the mixture to react for 8 to 10 hours under stirring at 27 - 35°With, by filtration, washing with deionized water and drying the precipitate under vacuum obtaining 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

In one of the embodiments of the present invention brainwashee means includes a combination of every 54-301 mmol bromides of alkali/alkaline earth metal, 27-150 mmol of bromato alkali/alkaline earth metal.

In yet another embodiment of the present invention bromination of phenol initiate the addition of 36% hydrochloric acid in 10-50 ml of water and brainwashes tools, including bromide, alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in 60-300 ml of water.

In yet another embodiment of the present invention the reaction of the synthesized carried out at a temperature in the range 27 - 35°C.

In yet another embodiment of the present invention bromination of phenol initiate the addition of a mixture of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in 60-300 ml of water, to the mixture of phenol and 36% hydrochloric acid in 10-50 ml of water.

In another embodiment of this invention the reaction of the synthesized initiate simultaneous addition of oxalic acid or citric acid, dissolved in 10-30 ml of water, to a mixture of phenol, bromide is Christmas/alkaline earth metal bromate alkali/alkaline earth metal 60-300 ml of water.

Detailed description of the invention

In accordance with this invention 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TBTO) is produced by the overall reaction represented in equation

The reaction is carried out in a round bottom flask (0.1 or 1.0 l), provided with a device for slow adding solutions from the outside and a mechanical device for mixing the contents in it. A known amount of phenol and the calculated amount of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal laboratory purity (about 99% purity) dissolved in water. The temperature in the flask support in the range of 27-35°C. With stirring, add the calculated amount of 36% aqueous hydrochloric acid for 2 hours. Stirring is continued for another 2 hours. The content is filtered, the crude product is washed with a sufficient amount of water, dried under vacuum, weighed and determine the melting point.

In a related method, the required number of 36% hydrochloric acid were placed together with phenol, dissolved in water, and the reaction of the synthesized initiate gradual addition of an aqueous solution containing the required number bromidic and romatnic salts.

In another related method, the required amount the VA salt, i.e. bromide and bromate, and organic acid in a minimum amount of water was placed together with phenol, and the reaction to allow flow in time with constant stirring. See that the temperature in the vessel was between 27 and 35°C. it is Recommended to use hydrochloric acid as it minimizes the response time. The reaction product is characterized by elemental analysis,1H-NMR, IR and melting point.

The present invention describes the obtaining of 2,4,4,6-tetrabromo-2,5-cyclohexadienone in one capacity bromirovanii phenol with a mixture of bromine and bromato alkali/alkaline earth metal and a mineral or organic acid.

The method of the present invention includes (i) the reaction of phenol with a mixture of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal in deionized water by slow addition of 36% hydrochloric acid for a period of two hours; (ii) alternatively, the slow addition of an aqueous solution of bromide of alkali/alkaline earth metal bromate alkali/alkaline earth metal to the mixture of phenol and 36% hydrochloric acid for a period of two hours, and stirring for another two hours, or neonatale, (iii) simultaneously adding a moderately strong organic acid to the aqueous solution of phenol bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal and stirring for 8-10 hours at ambient temperature. The obtained product was separated by filtration, washed with deionized water and dried under vacuum to obtain 91-94% of untreated 2,4,4,6-tetrabromo-2,5-cyclohexadienone, melting at 123-127°C.

Signs providing inventive step of this invention, are the following:

i) to produce active forms of bromine used bromides of alkali/alkaline earth metal bromates alkali/alkaline earth metal, which eliminates the need of using liquid bromine,

ii) the starting material for this synthesis is phenol, easily available and cheap in comparison with 2,4,6-tribromophenol,

iii) the reaction is carried out in a purely aqueous medium, eliminating the need to use organic solvents, which require an additional surgery to remove the organic solvent.

The following examples are given for illustration and should not be construed as limiting the scope of the invention.

EXAMPLE 1

To a well stirred solution of 2.00 g (21 mmol) of phenol, 5,97 g (58 mmol) of sodium bromide and of 4.38 g (29 mmol) of sodium bromate in 60 ml of deionized water in dvuhholos 100 ml round bottom flask was slowly added to 8.7 ml (3,14 g, 86 mmol) of 36% hydrochloric acid for 2 hours. The content was stirred for another 2 hours. Osujdenni the product was filtered, twice washed with deionized water and dried in vacuum for 6 hours. The total yield of the crude 2,4,4,6-tetrabromo-2,5-cyclohexadienone was 8,11 g (93%). The characteristic parameters set for the selected sample with a melting point 125°C: IR (KBr) ν 634, 663, 702, 900, 1310, 1454, 1582, 1680, 3051 cm-1;1H-NMR(CDCl3, 200 MHz) δ: 7,78 (s, 2H) and elemental analysis observed 17,16 (%) 0,24 (%H)calculated for C6H2Br4ABOUT: 17,56 (%) 0,49 (%N).

EXAMPLE 2

To a well stirred solution of 10.00 g (106 mmol) of phenol, 29,60 g (287 mmol) of sodium bromide and 21,70 g (144 mmol) of sodium bromate in 275 ml of deionized water in dvuhholos 500 ml round bottom flask was slowly added to the mixture 43,7 ml (15,70 g, 431 mmol) of 36% hydrochloric acid in 50 ml of water within 2 hours. The content was stirred for another 2 hours. The precipitated product was filtered, washed twice with deionized water and dried in vacuum for 6 hours. The total yield of the crude 2,4,4,6-tetrabromo-2,5-cyclohexadienone amounted to 40.1 g (92%). The characteristic parameters set for the selected sample with a melting point 125°C: IR (KBr) ν 634, 663, 702, 900, 1310, 1454, 1582, 1680, 3051 cm-1;1H-NMR(CDCl3, 200 MHz) δ: 7,78 (s, 2H) and elemental analysis observed 17,16 (%) 0,24 (%H)calculated for C6H2Br4ABOUT: 17,56 (%) 0,49 (%N).

EXAMPLE 3/p>

To a solution of 5.00 g (53 mmol) of phenol and 22.0 ml (7,93 g; 220 mmol) of 36% hydrochloric acid in 100 ml of deionized water in a 500 ml dvuhholos flask with equipment that provides good mixing, was slowly added a mixture of 15.00 g (145 mmol) of sodium bromide and 10.93 g (72 mmol) of sodium bromate in 50 ml of deionized water for 2 hours. After additional stirring for 2 hours the precipitated product was separated by filtration, washed with deionized water and dried in vacuum, obtaining of 19.8 g (91%) of the crude 2,4,4,6-tetrabromo-2,5-cyclohexadienone, melting at 125°C; IR (KBr) ν 634, 663, 702, 900, 1310, 1454, 1582, 1680, 3051 cm-1;1H-NMR(CDCl3, 200 MHz) δ: 7,78 (s, 2H) and elemental analysis observed 17,16 (%) 0,24 (%H)calculated for C6H2Br4ABOUT: 17,56 (%) 0,49 (%N).

EXAMPLE 4

To a well stirred solution of 5.00 g (53 mmol) of phenol, 15,00 g (145 mmol) of sodium bromide and 10.93 g (72 mmol) of sodium bromate in 100 ml of deionized water in a 250 ml round bottom flask was slowly added 27,72 ml (220 mmol) of oxalic acid dihydrate in 50 ml of water for 10 minutes. The content was stirred for another 8 hours. The precipitated product was filtered, washed twice with deionized water and dried in vacuum for 6 hours. The total yield of the crude 2,4,4,6-tetrabromo-2,5-cyclohexadienone amounted to 20.5 g (94%)which melted at 123°C; IR (KBr) = 634, 663, 702, 900, 1310, 1454, 1582, 1680, 3051 cm-1;1H-NMR(CDCl3, 200 MHz) δ: 7,78 (s, 2H) and elemental analysis observed 17,16 (%) 0,24 (%H)calculated for C6H2Br4ABOUT: 17,56 (%) 0,49 (%N).

The main advantages of this method are:

1. It is not used directly in liquid bromine for the synthesized phenol.

2. It is not required to start the reaction with tribromophenol.

3. Brainwashee substances and other chemicals are environmentally convenient and non-toxic and polluting the air.

4. For pomeroyi substances do not require special equipment and safety devices.

5. Not responsible for the generation of toxic by-products, such Hydrobromic acid.

6. The alkaline solution obtained as an intermediate in the extraction of bromine from the mother liquor by means of low-temperature process can be used as brainwashes substances.

7. Mineral acid or organic acid is not dangerous, and their number can be minimized.

8. The reaction of the synthesized directly gives almost pure product in solid form, thereby reducing to the minimum requirements for the operating Protocol and clean.

9. In this way water is used as a cheap and environmentally benign solvent.

1. The method of obtaining 2,4,4,6-tetrabromo-2,5-cyclohexa is the exact location in the same container, including the interaction of phenol with brainwashin means consisting of a mixture of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in deionized water, in the presence of acid, separation, washing and drying the precipitate to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

2. The method according to claim 1, wherein the organic acid is selected from the group consisting of oxalic acid and citric acid.

3. The method according to claim 1, wherein the acid comprises hydrochloric acid.

4. The method according to claim 1, in which used the phenol is phenol laboratory purity.

5. The method according to claim 1, comprising the reaction of from 2 to 10 g (21-106 mmol) of phenol with a mixture 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth metal dissolved in 30 (weight/weight.) equivalents of deionized water by slowly adding a 3.5-16.0 g (96-438 mmol) of 36%hydrochloric acid 5 (weight/weight.) equivalents of deionized water for two hours, allowing the reaction, filtering off the precipitate, washing and drying under vacuum to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

6. The method according to claim 1, comprising the slow addition of a solution 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth m is metal, dissolved in 15 (weight/weight.) equivalents of deionized water, to a mixture of 2-10 g (21-106 mmol) of phenol and 3,5-16.0 g (96-438 mmol) of 36%hydrochloric acid 20 (weight/weight.) equivalents of deionized water for two hours; continue stirring for two hours, filtering off the precipitate, washing and drying to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

7. The method according to claim 1, comprising simultaneously adding 87-436 mmol moderately strong organic acid, dissolved in 5 (weight/weight.) equivalents of water to the mixture of phenol, bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in 30 (weight/weight.) equivalents of deionized water, allowing the mixture to react for 8-10 hours under stirring at 27-35°, filtration, washing with deionized water and drying the precipitate under vacuum obtaining 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

8. The method according to claim 1, in which brainwashee tool consists of a combination of 27-150 mmol of bromato alkali/alkaline earth metals, taken on every 54-301 mmol bromides of alkali/alkaline earth metal.

9. The method according to claim 1, in which the bromination of phenol initiate the addition of 36%hydrochloric acid in 10-50 ml of water and brainwashes means consisting of bromide alkali/alkaline earth metal and bromatologia/alkaline earth metal, dissolved in 60-300 ml of water.

10. The method according to claim 1, wherein the reaction of the synthesized carried out at a temperature in the range of 27-35°C.

11. The method according to claim 1, in which the bromination of phenol initiate the addition of a mixture of bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal dissolved in 60-300 ml of water, to the mixture of phenol and 36%hydrochloric acid in 10-50 ml of water.

12. The method according to claim 1, wherein the reaction of the synthesized initiate simultaneous addition of oxalic acid or citric acid, dissolved in 10-30 ml of water, to a mixture of phenol, bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal 60-300 ml of water.

13. The method of obtaining 2,4,4,6-tetrabromo-2,5-cyclohexadienone in the same container, including interaction 2-10 g (21-106 mmol) of phenol with a mixture 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth metal dissolved in 30 (weight/weight.) equivalents of deionized water by slowly adding a 3.5-16.0 g (96-438 mmol) of 36% hydrochloric acid 5 (weight/weight.) equivalents of deionized water for two hours, allowing the reaction, filtering off the precipitate, washing and drying under vacuum to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

14. The method of obtaining 2,4,4,6-tetrabromo-2,-cyclohexadienone in the same container, including the slow addition of a solution 54-301 mmol bromide alkali/alkaline earth metal and 27-150 mmol bromate alkali/alkaline earth metal dissolved in 15 (weight/weight.) equivalents of deionized water, to a mixture of 2-10 g (21-106 mmol) of phenol and 3,5-16.0 g (96-438 mmol) of 36%hydrochloric acid 20 (weight/weight.) equivalents of deionized water for two hours; continue stirring for two hours, filtering off the precipitate, washing and drying to obtain 2,4,4,6-tetrabromo-2,5-cyclohexadienone.

15. The method of obtaining 2,4,4,6-tetrabromo-2,5-cyclohexadienone in the same container, comprising simultaneously adding 87-436 mmol moderately strong organic acid, dissolved in 5 (weight/weight.) equivalents of water to the mixture of phenol, bromide alkali/alkaline earth metal bromate alkali/alkaline earth metal 30 (weight/weight.) equivalents of water; enabling the mixture to react for 8-10 hours under stirring at 27-35°, filtration, washing with deionized water and drying the precipitate under vacuum obtaining 2,4,4,6-tetrabromo-2,5-cyclohexadienone.



 

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FIELD: chemical industry; new method of production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon.

SUBSTANCE: the invention is pertaining to the new method of production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon, which one has the wide application as the semi-finished product in chemistry of organic synthesis, for example at production of the linear poly(phenylene oxides). The method consists in production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon in one container and provides for interaction of phenol with the brominating substance consisting of the mixture of the alkaline metal /alkaline earth metal bromide and the alkaline metal /alkaline earth metal bromate soluted in the deionized water at presence of the acid, extraction, washing and drying of the deposit with production of 2,4,4,6-tetrabromine-2,5-cyclohexadienon. The technical result of the invention is simplification of the production process due to usage of phenol as the original substance and the combination of the alkaline metal /alkaline earth metal bromides and the alkaline metal /alkaline earth metal bromates.

EFFECT: the invention ensures simplification of the production process due to usage of phenol as the original substance and the combination of the alkaline metal /alkaline earth metal bromides and the alkaline metal /alkaline earth metal bromates.

15 cl, 4 ex

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