Method for treating psoriasis

FIELD: medicine, dermatology.

SUBSTANCE: it is necessary to carry out desensitization, disintoxication therapy due to an enterosorbent, apply preparations for external usage, fulfill about 10-30 procedures of general photochemotherapy 3-4 times weekly at introducing ammifurin at the dosage of 20 mg/20 kg body weight 3 h before the procedure and, also, at introducing Hendevitum per 2 lozenges daily for 3 wk and, additionally, it is necessary to introduce sedative herbal species nocturnally for 1 mo. The innovation provides shortened terms for treating psoriasis, increased period for remission, usage in wide-age group of patients, availability to be used both under out- and in-patient conditions due to applying larger dosage of ammifurin per kg patient's body weight and its earlier introduction at no side effects.

EFFECT: higher efficiency of therapy.

9 cl, 3 ex

 

The invention relates to medicine, namely to the use of radiation therapy in the treatment of psoriasis, neurodermatitis, occupational dermatitis, mycosis.

There is a method of treatment of psoriasis tigazon in combination with photochemotherapy (FHT). The essence of treatment is to accept tigason 75 mg per day for 14 days followed by photochemotherapy (FHT) on a 4-day method with the admission of the sensitizer pualina and a simultaneous reduction in the dose of tigason to 50 mg per day to the state of clinical recovery (the Magazine "Soviet medicine", 1987, No. 8, p.77-80).

There is a method of treating psoriasis, comprising oral administration of tigason in combination with photochemotherapy (FHT) on a 4-day method with the admission of the sensitizer pualina, in the days of the photochemotherapy simultaneously with povoleno appoint tigazon 25 mg per day (Patent of Russian Federation №2061483, IPC: a 61 K 31/59, a 61 P 17/06, 1996, bull. No. 16).

The method is as follows. Spend photochemotherapy 4-day method with the admission of the sensitizer pualina according to the standard technique: the patient is prescribed oral photosensitizer puvalen based 0.6 mg per kilo of body weight and after 2 h of UV irradiation with a wavelength of 320-360 nm. Simultaneously with the admission pualina given orally 1 capsule (25 mg) tigason in d and holding FHT. Externally use a combination of 2% salicylic ointment and cream Uns.

A disadvantage of the known methods of treatment of psoriasis are lasting up to 10 weeks, the presence of side effects (peeling of the skin, dryness of the lips, intermittent nasal bleeding, disfuncao liver and other)caused by the prolonged use of tegatana. This remission after treatment does not exceed 6-8 months.

There is a method of treatment of psoriasis, including photochemotherapy 4-day method with the admission of the sensitizer pualina, in which an hour before exposure to the lesions cause 5% ointment askola based title (Patent of Russian Federation №2088225, IPC: a 61 N 31/07, a 61 P 17/06, 1997, bull. No. 24). Actual components ointments are vitamins a and E. the Use of vitamins a and E topically in combination with long-wave ultraviolet radiation (wavelength 320-400 nm) has a positive effect on psoriasis. The method is as follows. Spend photochemotherapy 4-day method with the admission of the sensitizer pualina. The patient is prescribed oral photosensitizer puvalen based 0.6 mg per kilo of body weight and after 2 h of UV irradiation with a wavelength of 320-400 nm in one-time initial time dose of 3 min, with increasing time of irradiation for 3 minutes after every procedure 3 to 15 min, the intensity of Yunosti irradiation ranges from 1.5 to 7.5 j/cm 2. Irradiation is carried out 1 time per day 4 times per week. Parallel to 1 hour before irradiation, topically to the lesions cause the ointment of askola prepared on the basis of TESOL. Remission after treatment does not exceed 6-8 months.

There is a method of treating psoriasis, comprising applying to the affected skin areas of medicinal substances with subsequent UV irradiation, in which 1.5 hours before irradiation is applied to the skin ointment containing 5% metronidazole and 10% Dimexidum, and irradiation is carried out at a wavelength of 280-400 nm (Patent of Russian Federation №1568318, IPC: a 61 N 5/10, 1999, bull. No. 24). In patients after treatment remained a rash on the scalp, pigmentation was observed on the skin of the torso, arms, thighs, erythema on the skin of the legs. The duration of remission after treatment does not exceed 6-8 months.

There is a method of treatment of psoriasis, including photochemotherapy 4-day method with the admission of the sensitizer pualina, which is in parallel with the FHT prescribe vitamin D21000 ME 3 times a day and vitamin a 3,300 ME 3 times a day for 3 weeks.

The method is as follows. Spend photochemotherapy 4-day method with the admission of the sensitizer pualina according to the standard technique: the patient is prescribed oral photosensitizer puvalen a rate 0.6 mg per one kg mA the son of the body, and after 2 h of UV irradiation with a wavelength of 320-360 nm. Simultaneously with the admission pualina given orally 1 capsule (25 mg) tigason in the days of the FHT. Externally use a combination of 2% salicylic ointment and cream Uns. Parallel to appoint 2 tablets (1 tablet - 500 ME) vitamin D2(ergocalciferol) 3 times a day and 1 jar (1 jar - 3300 ME) vitamin a (retinol acetate) 3 times a day after meals, for 3 weeks (Patent of Russian Federation №2135184, IPC: a 61 K 31/59, a 61 P 17/06, 1999, bull. No. 24). The disadvantage of this method is the low period of remission after treatment is 4-6 months.

There is a method of treatment of psoriasis on the basis of therapy, which is used on the background of standard therapy (desensitization using blockers H1receptors, indifferent ointments, ultraviolet radiation) and is a drug-free stimulation system of natural immunity, physiological mechanisms sanogenesis with normalization of vital processes, detoxification of the body by the elimination of the biological fluids of various xenobiotics, toxins and products of metabolic amputation" (Sharapova GY and other Psoriasis (immunogenity pathogenesis and treatment methods). M, Medicine, 1989, s.89-140).

However, this method of therapy has several disadvantages: requires special equipment and specially trained personnel, with their high efficiency is not PR is long-term remission, has side effects, age restrictions and contraindications associated with the concomitant diseases.

There is a method of treatment of psoriasis during therapy, including desensitization, indifferent ointments and ultraviolet irradiation, at which carry out the comprehensive immunotherapy, including detoxification therapy using enterosorbent, for example activated carbon, descending to the scheme within 2 months, the immunomodulation of T-activin, depending on the severity and duration of the disease from 2 to 6 months, normalization of liver function by Kars, vascular therapy "Aevit" and multivitamin with minerals in alternation month courses year-round (Patent of Russian Federation №2149002, IPC: a 61 K 31/49, 2000, bull. No. 4, (prototype)).

When properly integrated approach to the treatment of psoriasis, the method is extremely long, and remission as well as analogues, does not exceed 6-8 months.

The proposed method eliminates the drawbacks and prototype.

Technical and medical result of the invention is the shortening of the treatment of psoriasis, the extension of the remission period, applicability to patients of any age, the reliability of the interaction of psoralen and ultraviolet radiation.

The technical result is achieved in that in the method of treatment of psoriasis, including de is ensibilizacion, ultraviolet irradiation, detoxification therapy using enterosorbent, the use of external funds and taking multivitamins, spend from 10 to 30 times the total photochemotherapy 3-4 times a week with a dose of amigorena 20 mg per 20 kg of body weight for 3 hours before the procedure, as multivitamins enter hendevit 2 tablets a day for 3 weeks and impose additional soothing herbal tea at night during the month.

Procedures General photochemotherapy in generalized vulgar and pustular psoriasis is carried out with the receiving neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

As external therapy prescribed by a keratolytic and/or lotion with kortikosteroidnymi ointment or shampoo with tar, or shampoos containing keratolytic salicylic acid.

If there are cracks and severe dryness plaque on the elements prescribed cream or ointment containing vitamin a: oil tykveol, ointments Radevit or vidistis, cream F-99.

On the eighth procedure locally applied on the plaque elements of a 0.3% solution of amigorena, and if carpeneti process on the scalp cause the ointment: sulfur or birch tar, or Lorenzen or clotrimazole.

If carpeneti process of the skin after Estoy procedures continue FHT, increasing the dose of amigorena per tablet, strengthen ointment therapy using corticosteroid creams with salicylic acid or corticosteroid ointment without keratolytic short course of 3-5 days, or designate neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

If carpeneti process of the skin after the fifteenth procedures continue FHT, increasing the time of exposure to ultraviolet radiation, enhance ointment therapy, dealing diprosalic or mud, or corticosteroid ointment without keratolytic: Elokim, advantan short course of 3-5 days.

If carpeneti process of the skin to appoint neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

If carpeneti process of the skin after the twentieth procedures prescribed Essentiale Forte 1 capsule 3 times a day for 3 months and topical therapy, while maintaining infiltration and desquamation on a separate plaque elements corticosteroid ointment with salicylic acid, or with strong predominance of exudative component on a separate plaque elements corticosteroid ointment without a keratolytic,a short course of 3-5 days.

If carpeneti process of the skin after the twenty-fifth procedure continue FHT to thirty treatments, prescribe an ointment or lotion daivonex.

The method of treatment of psoriasis can be considered as incremental (step) standards for the management of the patient with psoriasis vulgaris (widespread - plaque form).

During the initial prima establish the diagnosis. When identifying problems with the internal organs appointed expert advice. Make an entry in the map. Prescribed treatment:

Step 1. Designate 10 treatments total photochemotherapy surface of the torso, arms, legs, shoulders, neck and scalp 3-4 times a week with a dose aminopurine 20 mg 20 kg plus 20 mg, 30-40 minutes after eating for 3 hours before the procedure.

In generalized vulgar and pustular psoriasis appoint RE-PUVA therapy with taking neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose. They control the biochemical blood parameters (total cholesterol, triglycerides, ALT, AST, alkaline phosphatase: before assigning neotigazon, within 10 days from the start of therapy and in the next 1 month.

In the presence of exudative process on the skin appoint a hypoallergenic diet (eliminate sweet, the system, marinades, meats, carbonated drinks). Prescribe antihistamines per os: suprastin 1 tablet at night 7 days or claritin 1 tablet at night 7 days.

Assign chelators: enterosgel 1 tablespoon 3 times a day for 10 days.

Appoint vitamins: hendevit 2 pills a day for 3 weeks and soothing herbal tea at night during the month, such as Collection, Valerian, motherwort.

Appoint external funds: when peeling on patchy elements - keratolytic salicylic ointment 2-3%) within 7 days.

For the scalp in the presence of papular rashes and lesions peeling prescribed lotion with kortikosteroidnymi ointments plus keratolytic: belosalic or diprosalik 1 times a day for 7-14 days or shampoo with tar, for example, T-gel, friderm, exposure time 3-5 minutes, every other day for months.

With abundant layering scales with the formation of the "shell" is prescribed shampoos containing keratolytic salicylic acid, such as Slicer, Certol C.

Step 2. 2-3 procedure to monitor the progress of treatment: the portability of a photosensitizer, if necessary repeat recommendations for its correct use.

Step 3. The inspection 5 the procedure of PUVA therapy. An entry in an out-patient map.

To determine the tolerability of treatment. If there are cracks and severe dryness on patchy cell battery (included) the tah to prescribe a cream or ointment, containing vitamin a: oil Tykveol, ointment Radevit, ointment Valentim, cream F-99.

Step 4. 8 the procedure of PUVA therapy: locally applied on the plaque elements of a 0.3% solution of amigorena, and if carpeneti process on the scalp put ointment prescription: sulphur, birch tar, Lorenzen And clotrimazole.

Step 5. Inspection 10 the procedure of PUVA therapy. An entry in an out-patient map. To discharge patients with clinical recovery.

If carpeneti skin process continue FHT, increasing the dose of amigorena on 1 tablet, strengthen ointment therapy:

- when stable infiltration and desquamation on a separate plaque elements prescribed corticosteroid creams with salicylic acid (Belosalic short course in 3-5 days);

with a steady predominance of exudative component on a separate plaque elements prescribed corticosteroid ointment without a keratolytic (Elokim or Advantan) a short course in 3-5 days;

- when torpid during the extensive process of the skin is to decide on the appointment of Neotigazon (assign biochemical analysis of blood, to determine the presence of contraindications).

Step 6. Inspection 15 the procedure of PUVA therapy. An entry in an out-patient map. To discharge patients with clinical recovery.

If carpeneti skin process continue FHT, increasing the time of impact the Oia UFA, and reinforce ointment therapy:

- when stable infiltration and desquamation on a separate plaque elements continue corticosteroid ointment with salicylic acid (Diprosalic short course (3-5 days);

- assign mud (mud lake Elton);

with a steady predominance of exudative component on a separate plaque elements continue to treat corticosteroid ointments without keratolytic product (Elokim, Advantan) short course 3-5 days;

- when torpid during the extensive process of the skin to appoint Neotigazon (instructions above).

Step 7. Inspection 20 procedure PUVA therapy (Re-PUVA therapy). An entry in an out-patient map. To discharge patients with clinical recovery.

- if carpeneti skin process continue FHT (Re-PUVA-therapy) and appoint: Essentiale Forte 1 capsule 3 times a day for 3 months;

Topical therapy:

- when stable infiltration and desquamation on a separate plaque elements prescribed corticosteroid creams with salicylic acid (Dermovate+2% salicylic ointment) short course 3-5 days;

with a steady predominance of exudative component on a separate plaque elements prescribed corticosteroid ointment without a keratolytic (Dermovate) short course of 3-5 days.

Step 8. Inspection on 25 procedure PUVA-therapy (P is-PUVA therapy). An entry in an out-patient map. To discharge patients with clinical recovery.

- if carpeneti skin process continue FHT (Re-PUVA-therapy) and appoint: Daivonex ointment or lotion Daivonex.

Step 9. Inspection on 30 procedure PUVA therapy (Re-PUVA therapy). An entry in an out-patient map. To discharge the patient with an appropriate diagnosis: Psoriasis, the stage of remission, clinical improvement;

Psoriasis, a stage of remission, a significant improvement;

Psoriasis, a stage of remission, improvement.

Patients undergoing an examination before a course of PUVA therapy, give orally (per os) psoralen (Amefuri or Oxsoralen - Ultra), which will be used for the treatment (and method of use - before eating or after eating, as well as the dosage is fully in line with those for subsequent treatment), and then irradiate the surface of the skin of the patient. For this guide and concentrate the parallel stream of rays toward the patient, which have a wavelength in the range of 320-350 nm. A focusing device for forming a spot with an area not exceeding 0,5-1,5 mm2forms the radiation dose in the range from 6 to 10 j/cm2.

Then irradiated fixed point on the patient's skin at regular intervals, for example every 30 minutes for 2-3 hours and 48-72 hours fixed arisen point PUVA erythema, PE is the first of which corresponds to the time of occurrence of psoralens in the patient's skin.

Here are some specific examples: 1. The patient ANF, weight 51 kg, were given three tablets of amigorena and was irradiated with a dose of 3 j/cm2, erythema appeared. 2. The patient BNA, weight 70 kg, gave 3,5 tablet amigorena and was irradiated with a dose of 5 j/cm2, erythema appeared. 3. The patient PTA, weight 82 kg, given 4 tablets of amigorena and was irradiated with a dose of 6 j/cm2, erythema appeared in 3 hours.

Statistical studies have shown that the dose of amigorena 20 mg 20 kg plus 20 mg, 3 hours before the procedure, guarantees the emergence of psoralen in the patient's skin after 3 hours, and General photochemotherapy 3-4 times reduces the treatment time and increase the period of remission. In particular, it was observed simultaneously 54 patients aged 14 to 44 years. The treatment was performed on an outpatient basis. Course duration FHT depended on the severity of the disease and the dynamics of the process of the skin. Averaged 10±1 session on the course with an average total dose of UVA 35±1 j/cm2. Clinical recovery was diagnosed in 36 (66.7%) patients, a significant improvement in 7 (13%), improvement in 4 (7.4 per cent). The lack of positive dynamics was observed in 4 (7,4%) patients. Poor tolerance FHT was observed in 3 people (5.5 per cent). Holding FHT was not accompanied by complications. Patients found no exacerbation of concomitant diseases. Remission lasted more than 12 months the century If the exacerbation may be repeated treatment.

1. A method of treatment of psoriasis, including desensitization, ultraviolet irradiation, detoxification therapy using enterosorbent, the use of external funds and taking multivitamins, characterized in that ultraviolet radiation is carried out from 10 to 30 times the total photochemotherapy 3-4 times a week with the introduction of amigorena at a dose of 20 mg per 20 kg of body weight for 3 h before the procedure, as multivitamins enter hendevit 2 tablets a day for 3 weeks and impose additional soothing herbal tea at night during the month.

2. A method of treating psoriasis according to claim 1, characterized in that the procedures total photochemotherapy in generalized vulgar and pustular psoriasis is carried out with the receiving neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

3. A method of treating psoriasis according to claim 1, characterized in that the external treatment prescribed by a keratolytic and/or lotion with a corticosteroid ointment or shampoo with tar, or shampoos containing keratolytic salicylic acid.

4. A method of treating psoriasis according to claim 1, characterized in that if there are cracks and severe dryness on patchy elements designate the REM or ointment, contains vitamins a: oil tykveol, ointments Radevit, widestep or cream F-99.

5. A method of treating psoriasis according to claim 1, characterized in that in the eighth procedure is additionally locally applied on the plaque elements of a 0.3%solution of amigorena, and if carpeneti process on the scalp cause the ointment containing sulfur or birch tar, or Lorenzen or clotrimazole.

6. A method of treating psoriasis according to claim 1, characterized in that when carpeneti process of the skin after the tenth procedures continue FHT, increasing the dose of amigorena per tablet, enhance outdoor therapy using corticosteroid creams with salicylic acid or corticosteroid ointment without keratolytic short course of 3-5 days, or designate neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

7. A method of treating psoriasis according to claim 1, characterized in that when carpeneti process of the skin after the fifteenth procedures continue FHT, increasing the time of exposure to ultraviolet radiation, enhance ointment therapy, dealing diprosalic or mud, or corticosteroid ointment without keratolytic: Elokim, advantan short course of 3-5 days.

8. A method of treating psoriasis according to claim 1, characterized in that if that is pignotti process of the skin to impose additional neotigazon 30-50 mg per day, in 2 doses, 2-4 weeks to obtain maximum therapeutic effect, then decrease dose by 10 mg per week to a maintenance dose.

9. A method of treating psoriasis according to claim 1, characterized in that when carpeneti process of the skin after the twentieth procedures prescribed Essentiale Forte 1 capsule 3 times a day for 3 months and topical therapy, while maintaining infiltration and desquamation on a separate plaque elements corticosteroid ointment with salicylic acid, or with strong predominance of exudative component on a separate plaque elements corticosteroid ointment without a keratolytic, a short course of 3-5 days.

10. A method of treating psoriasis according to claim 1, characterized in that when carpeneti process of the skin after the twenty-fifth procedure continue FHT to thirty treatments, prescribe an ointment or lotion daivonex.



 

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4 dwg, 1 ex, 1 tbl

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to creation of therapeutical and prophylactic balsams, which can be used as generally restorative and tonic agents to increase resistance of organism to reduced levels of atmosphere oxygen (increase of hypoxia resistance) as well as to prevention and correction of functional disorders associated with stress and exhausting environmental factors affecting organism. Invention proposes two variants of therapeutical-prophylactic balsam producing generally restorative and tonic effects, each containing vegetable oils, vitamins, amino acids, hepatic implant cells (Hepatosan), adaptogen (Astragerm), antioxidant, odorant, and thickener.

EFFECT: achieved normalization of vitality in exhausted organism.

6 cl

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of 4-phenylpyridine of the general formula: (I) wherein R means halogen or halogen atom; R1 means -(C≡C)mR1' or -(CR'=CR'')mR1'; X means -C(O)N(R8)-, -N(R8)C(O)- or -N(R8)-(CH2)p- wherein m = 0-4 and p = 1-2; values of radicals R1', R2, R3', R3, R4, R4', R8, R' and R'' are given above, and to their pharmaceutically acceptable acid-additive salts and a medicinal agent based on thereof. New compounds are neurokinine-1 antagonists and can be used as medicinal agents in treatment of diseases mediated by neurokinine-1 receptors.

EFFECT: valuable medicinal properties of derivatives.

13 cl, 119 ex

FIELD: pharmaceutical technology, pharmacy.

SUBSTANCE: method involves addition sugar-alcohol and/or saccharide showing melting point by 5°C lower or above as compared with the first mentioned sugar-alcohol and/or saccharide to sugar-alcohol and/or saccharide followed by combined treatment of prepared powder by pressing and heating. Invention allows preparing medicinal compositions decomposing in mouth cavity rapidly being without water and showing light using owing to the presence of sufficient strength in preparing, transport in usual using. Method involves mixing, pressing and heating components that represent two or more sugar-alcohol and/or saccharide and active component wherein difference between melting points of one among two or more indicated sugar-alcohol and/or saccharide that shows the higher content and any remaining indicated two or more sugar-alcohol and/or saccharide is 5°C or above. Invention provides preparing strength rapidly soluble tablets.

EFFECT: improved preparing method, improved pharmaceutical properties of composition.

30 cl, 12 tbl, 28 ex

FIELD: medicine, dermatology.

SUBSTANCE: the present innovation deals with treating different forms of localized sclerodermia: plaque, linear, scleroatrophic lichen, idiopathic atrophodermia. The method deals with introducing delagyl, xanthinol nicotinate, claritine, application of "Elocom" ointment. At the background mentioned one should alternate 8-10 procedures of intravenous injection of ozonized physiological solution at ozone concentration being 1.5 mg/l at the volume of 200 ml and 5-7 procedures of subcutaneous puncturing in lesion foci with oxygen-ozone gaseous mixture at ozone concentration of 2 mg/l. This mixture should be introduced along focal periphery at the volume of 10-30 ml. Intravenous injections should be carried out twice or thrice weekly, and subcutaneous puncturing - once or twice weekly. The innovation enables to decrease sickness rate due to increased velocity and full-value absorption of the ointment used, immunomodulating, antiphlogistic, collagen-formation and microcirculation normalizing effect of complex therapy, liquidation of tissue hypoxia and reflexogenic stimulation of body vascular system.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine, oncology.

SUBSTANCE: method involves carrying out chemotherapy. Firstly, dose of nicotinic acid is administrated that is sufficient to initiate hyperemia of skin integuments and in appearance of first symptoms of hyperemia cytostatics are administrated by parenteral route. Method provides increasing duration of contact of cytostatics with tumor cells and micrometastasis due to inclusion of blood volumes depots in the parent state in vascular skin networks to volume of circulating blood. Invention can be used in treatment of malignant neoplasms with cutaneous and subcutaneous localization.

EFFECT: improved treatment method.

2 ex

FIELD: pharmacy, medicinal biochemistry, nutrition.

SUBSTANCE: invention relates to an agent used in curative-prophylactic nutrition. Invention proposes composition for correction of the assimilation level of foodstuffs of lipid nature by a body that involves complex comprising equimolar water-soluble salt of chitosan with ascorbic, succinic and lipoic acids, substance of polyoxynaphthoquinone nature and marine echinoderms animals (Echinodermata), polyoxyphenolic compounds from grape bunches and trivalent chrome ions and a sweetening agent. As a sweetening agent fructose is used in its concentration in the end product 30-80%, not less. The content of substances of polyoxynaphthoquinone nature in the end product is 0.1 mg/ml, not less. The composition comprises trivalent chrome ions in the amount not exceeding the daily dose 50 mcg/24 h in a single intake. The composition can be prepared in form of syrup, gel, paste, tablet, powder or aerosol. Also, invention proposes a method for preparing the composition used in correction of the assimilation level of foodstuffs of lipid nature by a body. Method provides preparing the composition containing chitosan in the final concentration from 1% to 5%, substances of polyoxynaphthoquinone nature 0.1 mg/nl, not less, trivalent chrome ions in the amount not exceeding the daily dose 50 mcg/24 h in a single intake and fructose taken in the amount from 30% to 80%. Method for preparing the composition involves mixing chitosan with solution of ascorbic and succinic acid at temperature 15-50°C, and prepared mixture of chitosan with aqueous solution of ascorbic and succinic acid is kept for 10-36 h. Invention provides improving blood lipid spectrum, protects liver against adipose infiltration, promotes to reducing body mass, provides antioxidant protection of body. The composition can be used as a curative-prophylactic agent in obesity of 1-st and 2-d degree of atherosclerosis, heart coronary disease, in symptoms of "metabolic syndrome", liver adipose infiltration and adipose hepatosis.

EFFECT: valuable medicinal properties of composition.

11 cl, 6 tbl, 2 ex

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