Method for treatment of inflammation parodontium diseases

FIELD: medicine, in particular therapeutic stomatology.

SUBSTANCE: claimed method includes using of Bezornyl ointment, wherein in generalized paradontitis of mild case ointment is applied on region of marginal parodontium and dentogingival papillae in dose of 0.005-0.1 g under dressing for 2 hours, and in generalized paradontitis of medium and severe case ointment is introduced directly in each parodontal pocket in dose of 0.005 g. Treatment course is 2-5 procedures with interval of 1 day.

EFFECT: effective preparation for topical application without administration of antibiotics and complex preparations.

2 ex, 1 tbl

 

The invention relates to medicine, namely to dentistry.

In etiotropic therapy of inflammatory periodontal diseases are widely used antibiotics, sulfonamides, antiseptics, but this antibacterial therapy can upset the balance of microflora in the oral cavity, but also prevent the formation of immune response to pathogens (Grigorian A.S., grudanov A.I., Rabuchin N.A., Frolova O.A. periodontal Diseases. - M: Medical information Agency, 2004, s-289). The basis of pathogenetic treatment of a greater role for the anti-inflammatory means, namely, steroid drugs and non-steroidal means, which act on the phase of alteration, exudation, proliferation (Krylov .F., Zoryan E.V. the Use of anti-inflammatory drugs in periodontics // Dentistry. Spec. vol. - 1998. 49 - 50). These include glucocorticoids, Enoxolone, Indomethacin, Diclofenac sodium, Piroxicam, and Movalis, Dimexidum, but these drugs cause irritation of the gastrointestinal tract, the Central nervous system. For the local treatment of periodontitis use of indomethacin ointment, the ointment "Levocin"and "Troksevazina" in the form of a 2%gel, 10%butadiene ointment applicationno under a bandage or tape long course of 8-10 treatments (Borovsky E.V., Willow is s B.C., Maximov, Y.M., L. Maximov. Therapeutic dentistry. - M.: Medicine, 1998, s.431-442).

An alternative to the use of nonsteroidal anti-inflammatory drugs is a homeopathic medication Traumeel-S", providing multi-effects. The drug contains 14 components of vegetable and mineral origin, which eliminates venous congestion, reduce tissue swelling, analgesic and have an antiplatelet effect, improve cellular respiration. To apply Traumeel-With you inside, in the form of injection or topically. In a generalized periodontitis of moderate and severe use sublingual tablets or injections of the drug at transition fold (Zoryan E.V. Essays on homeopathy for dentists. - M.: Ardebil, 2005, p.78). For the treatment of catarrhal gingivitis and periodontitis mild severity, use the ointment "Traumeel-S". Provides professional oral hygiene, which includes the removal of above - and subgingival dental plaque, washing pockets with mild periodontitis, overlapping gingivitis and mild severity of periodontitis in view of the applications of the ointment "Traumeel-S for 7 days (Zoryan A.V. Comparative evaluation of the efficacy of local application of various groups of anti-inflammatory drugs in catarrhal gingivitis and periodontitis became the second degree: author. dis ... CMN / Moscow state medical dental University. - 2004. - 23 C.). This method is chosen for the prototype.

Ointment "Bazarny" is a medicinal product for external use, production of the 3rd pharmaceutical factory Mainlan Wuhan, China. In the composition of ointments "Bazarny include camphor, calamine, pearls, amber, artificial musk, artificial bezoar, and is intended for the treatment of hemorrhoids, cracks and eczema of the anus. The ointment is a comprehensive drug and has astringent, anti-inflammatory, regenerating local and local anesthetic effect. Due to the diverse actions ointment "Bazarny" has a more pronounced anti-inflammatory effect.

The objective of the invention is to increase the effectiveness of local treatment of inflammatory periodontal diseases and the reduction of treatment time.

This is due to the fact that as the integrated product is used ointment "Bazarny", which is placed on the area of inflammation in the amount of 0.005-0.1 g under a bandage for 2 hours with an interval of 1 day course 2-5 treatments, while moderate and severe periodontitis ointment "Bazarny" injected directly into each periodontal pocket in a dose of 0.005,

Ointment "Bazarny" has a stronger antimicrobial and anti-inflammatory effect sravnenie the "Traumeel". The presence of the drug in moderate and severe periodontitis directly in the area of inflammation in the periodontal pocket - provides the most efficient therapeutic effect, which is to reduce inflammation, relieve swelling, the appearance of comfort in the mouth, the disappearance of bleeding, improving oral hygiene. The dosage and duration of treatment tested in clinical practice and are optimal. In the prototype method, for example, in the treatment of mild periodontitis takes 7 days, and by the proposed method - 4 days intervals, i.e. two visits by the patient's physician.

The drug efficacy was assessed by clinical examination, which included: examination of the tissues of the oral cavity, the determination of the degree of tooth mobility, the depth of periodontal pockets (in the case of treatment of periodontitis), for the objective assessment of periodontal status, used data from x-ray and standard indexes: the index of the RMA (in the modification of Parma), the index of hygiene Greene-Vermillion (OHI-S) and the index bleeding on Muhlemann (SBI). In the mixed saliva, reflecting the state of periodontal tissues, we determined the activity of antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPO). The evaluation index values and the dynamics of change the clinical picture of the periodontal condition was performed before the study, during the period of drug therapy and after its completion.

Changes in the state of periodontal tissues using the ointment "Bazarny" on the example of the treatment of periodontitis (4th day).

IndexPeriodontitis mild severity (n=6)
Prototype methodThe proposed method
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatment
The hygiene index1,40±0,200,20±0,052,0±0,210±0
The index bleeding2,10±0,201,52±0,312,19±0,230,30±0,04
PMA25,5±2,54,9±0,626,2±2,422,0±0,1
Periodontitis severe severity (n=6)
The hygiene index4,0±0,61,50±0,154,3±0,490,5±0,05
The index bleeding7,30±0,804,10±0,328,10±0,451,52±0,40
PMA60,1±2,60 25,5±2,664,2±6,04,9±0,45

The method is as follows: the patient after removal of above - and subgingival dental plaque, washing pockets antiseptics impose ointment "Bazarny" in the amount of 0.005 - 0.1 g (value 0.005 g obtained by weighting the ointment on an analytical balance and corresponds to the number of ointments applied to the tip graduated Pugacheva probe; this number is sufficient for application in the area of marginal periodontium one tooth, and 0.1 g on the entire area of the marginal periodontal) on the area of inflammation under medical bandage (for example, "Septopac") for 2 hours with an interval of one day course 2-5 procedures, as appropriate the severity of the inflammatory process. When gingivitis and mild severity of periodontitis enough for 2 treatments, moderate and severe severity of periodontal inflammation dosage and rate of increase. When moderate and severe periodontitis ointment injected directly into each periodontal pocket.

Clinical example 1.

Patient J. 36 years. Diagnosis: Generalized periodontitis mild severity. Index PMA 14%, the index of hygiene 2,9; index bleeding 2,2; the depth of periodontal pockets up to 3 mm, when the examination revealed redness, swelling gums, saliva and SOD activity=5 IU/l, CL=39 IU/l In the treatment on offer : the Boo, which consisted of 2 treatments with an interval of one day, the ointment "Bazarny" in a dose of 0.1 g was imposed on the area of marginal periodontal and gingival papilla. Examination after treatment showed that the gums are pale pink in color, dense, disappeared bleeding, there were no clinical signs of inflammation, index PMA 2,0%, IG and IR - 0, saliva and SOD activity=2 IU/l, gap=0 IU/L.

Clinical example 2.

Patient K. 48 years. Diagnosis: Diabetes mellitus type I, generalized severe periodontitis severity. Before treatment, the index PMA 68%, the index of hygiene 4,5; index bleeding 8,0; the depth of periodontal pockets from 3 to 6 mm, when the examination revealed redness, swelling gums, saliva and SOD activity=9 IU/l, CL=46 IU/l After treatment, which consisted of 5 treatments with an interval of one day, during which each periodontal pocket was introduced ointment "Bazarny" in a dose of 0.005 g under the bandage, when inspecting the gums are pale pink in color, dense, no bleeding, no clinical signs of inflammation, index PMA 33%, IG 2.0% and IR - 1,60; in saliva SOD activity=2.5 IU/l, CL=8 IU/L.

Thus, the ointment "Bazarny" on the proposed method allows to reduce the inflammation in 2-5 visits on a simplified treatment technology, eliminating the use of antibiotics by mouth or injection, the introduction of complex products by type infiltration Ana is the tezia).

The method of treatment of inflammatory periodontal diseases by topical application of the integrated product, characterized in that the integrated product is used ointment "Bazarny", when generalized periodontitis mild ointment put on the area of marginal periodontal and gingival papilla at a dose of 0.005-0.1 g under the bandage on for 2 hours, in a generalized periodontitis of moderate and severe ointment injected directly into each periodontal pocket in a dose of 0.005 g, treatment 2-5 treatments with an interval in 1 day.



 

Same patents:

FIELD: medicine, therapeutic stomatology.

SUBSTANCE: method involves administration of the medicinal composition into parodontal pockets that is prepared ex tempore and comprising 2 parts of porous hydroxyapatite ceramic with granules size 0.3-0.5 mm, 1 part of zinc oxide powder with addition of 30% solution of lincomycin. Also, method involves coating with fluorolacquer for 12-24 h with treatment course by 6-8 procedures for every day. Method provides effective treatment, prolongation of stable clinical remission being without surgery operation. Invention can be used in treatment of parodontitis of middle severity degree.

EFFECT: improved method of treatment.

7 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: method involves administering oral cavity rinsing with 1.5-2.0% aqueous Achilles salt solution at least 4 times a day during at least 1 month.

EFFECT: enhanced effectiveness in repairing physical, chemical and biological saliva properties.

3 tbl

FIELD: medicine.

SUBSTANCE: method involves making instillations and applications with Cholisal gel 2-3 times a day. Imudon is introduced at a dose of 6 pills a day during 20 days. Polysorb MP is introduced at a dose of 1 tea spoon diluted with 100 ml of water once a day during 20 days.

EFFECT: enhanced immunotropic, detoxifying effectiveness together with bactericide and anti-inflammatory action; increased organism resistance.

3 tbl

FIELD: stomatology.

SUBSTANCE: invention, which can be used to treat paradentium diseases accompanying inflammation or recession of marginal gum tissues, comprises performing vestibuloplastics and laying Diplen-Denta film containing Oliphen daily starting on the second postoperative day during five days.

EFFECT: increased vitality of marginal gum tissues due to enhanced energy exchange and microcirculation.

6 dwg, 6 tbl, 2 ex

FIELD: medicine, therapeutic stomatology.

SUBSTANCE: one should apply special medicinal preparations immobilized upon gelatin-glycerin splin, the foundation of which is presented as 28.57% gelatin, 17.86% glycerin and 53.57% water. Moreover, during the first 3 d one should apply malavit thrice daily after breakfast, dinner and before nocturnal period. Then, during 3 d patients should apply medicinal splints with trental in the morning, and before nocturnal sleeping - those with thymogenum, at final stage of therapy for 3 d it is necessary to use splints with collargol in the morning and before nocturnal sleeping. The innovation enables to interrupt inflammatory process efficiently and short period of time due to high-degree releasing of medicinal substances at strong fixation of the splints applied.

EFFECT: higher efficiency of therapy.

2 cl, 1 ex

FIELD: medicine, stomatology.

SUBSTANCE: one should apply "dentin-sealing liquid" consisted of liquid 1 and liquid 2 and, also, additionally, one should apply gradual impact with low-intensity laser radiation upon dentin of prepared carious cavity after each impregnation with "dentin-sealing liquid", moreover, at first it is necessary to impregnate with liquid 2 and then - with liquid 1, then dentin should be again impregnated with liquid 2, moreover, "Aevit" is prescribed, as well. Thus, dentin-sealing liquid activated with laser radiation penetrates dentine canaliculi more deeply and gradual impact prolonged trace effect of laser radiation action.

EFFECT: higher efficiency of therapy.

4 dwg, 1 ex

FIELD: stomatology.

SUBSTANCE: to simulate erosion of solid dental tissues extracted human teeth are immersed for 60 days into white dry wine while adding citric acid to pH 3.5. Such implementation of the method ensures development of erosion 2 mm deep, which is necessary for further working out of treatment methods.

EFFECT: enhanced development of simulated erosion.

FIELD: medicine.

SUBSTANCE: method involves exposing injured dental hard tissue areas to low intensity laser radiation for 30-50 s. The areas are first covered with enamel-sealing means liquid No1 and then with enamel-sealing means liquid No2. Tooth pastes containing calcium and phosphor or fluorides or potassium nitrate or strontium salts are administered and poly-vitamin complex containing macro- or microelements are given.

EFFECT: enhanced effectiveness of treatment.

4 dwg

FIELD: biotechnology.

SUBSTANCE: invention relates to inhibitor of matrix metalloproteinases representing extract from fungus Canoderma atrum obtained by using of water and/or lower alcohols as extractant. Also disclosed are pharmaceutical agent for inhibition of tumor metastasis containing of 0.03-10 wt.% of abovementioned extract and foodstuff containing claimed extract.

EFFECT: improved inhibitor of matrix proteinases.

3 cl, 18 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: method involves administering Buscopan per os at a dose of 10 mg 40 min before the intervention as premedication preparation.

EFFECT: enhanced effectiveness of premedication.

24 cl

FIELD: medicine.

SUBSTANCE: method involves carrying out vacuum massage of prostate with an apparatus. Tampons with 40-45°C hot sulfide mud taken from Sucsun pond are additionally rectally introduced for 20-30 min. The total treatment course is 8-10 procedures long. Daily microenemas are prescribed with mineral water at 36°C in a 10 procedures long course.

EFFECT: enhanced effectiveness of treatment.

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to inflammatory agents. Invention proposes the ointment that comprises liquid potassium humate, birch tar, sodium silicate, vaseline wherein the potassium liquid humate comprises the humic substances in the amount 4.5 g/l, not less. Invention provides enhancing storage time, stability, high effectiveness and the broad spectrum of effect.

EFFECT: valuable medicinal and pharmaceutical properties of ointment.

2 cl, 6 ex

FIELD: pharmaceutical industry, in particular production of moor preparation.

SUBSTANCE: claimed method includes extraction of moor raw material such as peaty piloids with decomposition rate of 50 % or more, decontamination, homogenization by agitation in mortar-mixer with addition of mineral sodium hydrocarbonate water under specific conditions followed by pulping through screen to produce product with shearing resistance of 1500-4000 din/cm3 and conserving agent addition. As conserving agent hydantoin in specific ratio is used. Then product is pre-packed in sealed containers and conditioned in stock for ageing.

EFFECT: peaty moor dough with increased biological value, high penetrability, improved nutrient and healing effects.

2 cl

FIELD: method for production of bioproducts from native divot peloid with high biological activity.

SUBSTANCE: claimed method includes extraction of fine dispersed divot peloid having plant residual decomposition ratio of 50 % or more with sodium hydrocarbonate-containing water at elevated temperature under intensive agitation to produce homogeneous suspension followed by separation under certain conditions.

EFFECT: ecologically pure concentrated peloid extract with high biological activity.

3 ex

FIELD: medicine, phthisiology.

SUBSTANCE: in early period the preparation "Yantar-antitoks" is used in the dose 0.5 g, 3 times per a day for one month in addition to the conventional antituberculosis therapy. Invention promotes to elimination of symptoms associated with the total intoxication, resorption of focus-infiltration changes, elimination of destructions and ceasing secretion of microorganisms for shorter periods. Invention can be used in treatment of pulmonary tuberculosis.

EFFECT: improved method for treatment.

4 tbl, 1 ex

The invention relates to the field of pharmaceutics and can be used in the treatment of prostatitis

The invention relates to veterinary medicine and can be used to treat skin injuries and wounds in animals

The invention relates to medicine, namely to preventive Oncology
The invention relates to medicine, veterinary medicine and pharmacy, perfume, food industry

Veterinary drug // 2214253
The invention relates to veterinary

FIELD: medicine, cosmetology.

SUBSTANCE: claimed method includes application of mask based on natural ion exchanger minerals or sorbents with addition of sterile fly larva ground to paste-like state in ratio of 1:2.5, wherein mineral part size is not more than 1 mm. Before application composition is agitated up to full paste absorption and dries for 30-40 min followed by application on skin surface.

EFFECT: mask with prolonged hemolymph storage time and increased effectiveness.

1 dwg, 4 cl

Up!