Organ- retaining method for treating uveal melanoma cases
SUBSTANCE: method involves administering Wobenzyme combined with brachytherapy with radiomodification and transpupillary thermotherapy or combined with isolated transpupillary thermotherapy. When combined with brachytherapy with radiomodification, Wobenzyme is given 2 days before brachytherapy at a dose of 3 pills 3 times a day with the exception of 8 h before fixation and removal of β-applicator. Next to it, Wobenzyme is given at a dose of 4-6 pills 3 times a day during 3 months. Then, the dose is reduced by 2 pills every month at the fourth, fifth and sixth months. Adjuvant transpupillary thermotherapy is carried out 6 months later after brachytherapy. Wobenzyme is given at a dose of 2-3 pills 3 times a day 2 days before transpupillary thermotherapy. Then, the dose is 4-6 pills 3 times a day during 2 months with following dose reduction by 3 pills every month to prophylactic dose of 1 pill a day. When carrying out isolated transpupillary thermotherapy, Wobenzyme is given in the same mode that it was the case when carrying out adjuvant transpupillary thermotherapy after brachytherapy. To prevent metastasis occurrence, Wobenzyme administration is continued at a dose of 1 pill 7 days every month during the first year and at a dose of 1 pill 3 days every month during the second observation year.
EFFECT: accelerated resorption processes; reduced risk of radiation treatment complications.
A priority in the treatment of the most common malignant intraocular tumors, uveal melanoma is isolated or integrated use of various methods of influence on tumor: radiation therapy (brachytherapy, teletherapy protons, helium ions or γ-rays), surgery (transscleral local resection), laser treatment (photo - and laser coagulation, transpupillary thermotherapy, photodynamic therapy), cryogenic [2, 3, 4]. The use of different methods or their combination allows to achieve tumor resorption at 90-93% of patients and reduce the risk of metastasis in the first 5 years up to 7-14%, compared with the frequency of metastasis after removal of the eye - 24-50% .
It is well known on the high radioresistance of melanoma tissue to radiation. In addition, due to pathological changes of microcirculation in tumors the majority of cells are in a state of chronic hypoxia, as a consequence, their sensitivity to radiation influence is sharply reduced. All this requires the impact of a total focal dose for a short time. Therefore, this method of radiation exposure is associated with development of severe complications in a high enough percentage: radiation cataracts (66%), proliferative retinopathy (25%), neuropathy (24%), case (23%), torinoi neovascular glaucoma (7%); thus, the effect obtained in the conservative treatment outweighed by the need enucleation of the eye.
Among the drugs that can improve microcirculation in the tissue, a special place belongs to the drugs systemic enzyme therapy with high efficacy and safety, such as Wobenzym.
Wobenzym is a mixture of hydrolytic enzymes of plant (papain, bromeline, rutin) and animal origin (trypsin, chymotrypsin, Pancreatin, amylase, lipase), which can significantly reduce the infiltration of interstitial space plasma proteins, increase the elimination of protein debris and deposits of fibrin in the hearth. This provides improved microcirculation in the damage zone and the reduction of local edema. Research conducted in the 60's, proved radioprotective action of papain by linking free radical groups . Because of the complex effects on individual components of the immunological processes through effects on cellular and humoral immunity, ability to split circulating in the blood and fixed tissues by immune complexes to exert a regulatory influence on the components of complement and adhesion molecules, as well as a pronounced anti-inflammatory effect and improve real the logical properties of blood, the change in the total proteolytic activity of blood, enzyme therapy is widely used in the treatment of various diseases, including cancer .
In the treatment of malignant tumors with the use of the drug in this group, Voba-Mugos E most important the following factors:
a) suppress the production of adhesion molecules that promote the metastasis of tumor cells and the development of postradiation complications;
b) increase fibrinolytic activity of blood;
C) increase the sensitivity of tumor cells to the effects of radiotherapy and cytotoxic drugs [5, 6].
The well-known scheme of the drug, Voba-Mugos E in malignant tumors [5, 6]: 6 to 12 tablets a day for 30 - 45 minutes before meals, not chewing and drinking plenty of water (200-250 ml). For the prevention of metastasis is prescribed 1 tablet daily for 7 days every month during the first year and within 7 days every second month during the second year.
When radiation therapy hydrolytic enzymes that are part of this group of drugs, allow not only to increase the radiosensitivity of the tumor, but mitigated the adverse factors of exposure, both in early and late period of observation . Thus, it is of interest to use the system exclusive enzyme therapy, namely Wobenzym in the multicomponent system conservative treatment of uveal melanoma. However, data about technology use in the treatment of uveal melanoma at the present time there is no.
It is known that in order to enhance the effect of brachytherapy apply various methods of influence on tumor tissue - microwave thermotherapy, laser therapy, laser photocoagulation, system prescribing cisplatin or iron-59 [2, 4]. But none of them is aimed at preventing the development of radiation damage.
The aim of the invention is to increase the efficiency of multicomponent conservative treatment of uveal melanoma and improving the quality of life of patients by reducing radiation damage.
This goal is achieved primarily through the use of diagrams and sequence of reception of Wobenzym in multicomponent conservative treatment of uveal melanoma, which allow you to use it with radiomodification in order to accelerate the resorption processes uveal melanoma and to reduce the severity of radiation damage to the organ of vision.
This goal is solved due to the fact that when the claimed method of treatment of uveal melanoma drug administered for two days before the start of the contact transscleral irradiation (brachytherapy), while exposed the Oia 3 tablets 3 times a day for 40 minutes before a meal, squeezed 200-250 ml of water, excluding the 8 hours prior to General anesthesia when fixing or removing β-applicator, after uninstalling β-applicator dose picked individually from 4 to 6 tablets 3 times a day for 3 months (during the formation of the early postradiation complications), then reduce the dose to 2 tablets up to 6 months; after transpupillary thermotherapy, both isolated and in the adjuvant treatment after brachytherapy, the drug is administered 2-3 tablets 3 times a day for 2 days before transpupillary thermotherapy, then from 4 to 6 tablets 3 times a day for 2 months after transpupillary thermotherapy, then reduce the dose to 3 tablets every month to prophylactic dose (1 tablet per day); to prevent the development of metastatic disease after brachytherapy and/or transpupillary thermotherapy taking Wobenzym prodajut 1 pill 7 days monthly during the first year, then 1 tablet 3 days monthly during the second year of observation.
Studies on patent and scientific and technical information sources showed that the proposed method for the treatment of uveal melanoma is not known and should not be explicitly studied the level of science and technology, that is, meets the criterion of "novelty". Drug use Wobenzym is known in medical practice, however good the songs have a distinctive action on their application, the sequence of application, it is possible to draw a conclusion on the conformity of the proposed method inventive step.
The proposed method of treatment is as follows.
The patient takes the drug "Wobenzym" 3 tablets 3 times a day for 40 minutes before eating, drinking 200-250 ml of water, excluding the 8 hours prior to General anesthesia when fixing or removing β-applicator, after uninstalling β-applicator dose picked individually from 4 to 6 tablets 3 times a day for 3 months, then reduce the dose to 2 tablets up to 6 months. Treatment after transpupillary thermotherapy, both isolated and in the adjuvant treatment after brachytherapy, was as follows: the drug is administered 2-3 tablets 3 times a day for 2 days before transpupillary thermotherapy, then from 4 to 6 tablets 3 times a day for 2 months after transpupillary thermotherapy followed by reduction of the dose to 3 tablets every month to prophylactic dose of 1 tablet a day. To prevent the development of metastatic disease after brachytherapy and/or transpupillary thermotherapy taking Wobenzym continued 1 pill 7 days monthly during the first year, then 1 tablet 3 days monthly during the second year of observation.
The method used in the conservative treatment of melanoma in fact the vessel is stand membranes of the eyes in 18 patients.
Monitoring effectiveness of treatment was combined clinical and instrumental examination, which included: visiometry, tonometry, perimetry, biomicroscopy, ophthalmoscopy, intravenous fluorescein angiography, ultrasound examination with color Doppler mapping. It was estimated the degree of resorption of the tumor, change its size, colors, patterns, dynamics of blood flow, the dynamics of visual functions, for radiation reactions and complications. In addition, conducted a physical examination of the patient to detect metastases.
In 18 patients (study group) in multicomponent treatment were included: brachytherapy with radiologicaly drugs platinum, transpupillary thermotherapy and Wobenzym.
22 patients (control group) brachytherapy with radiologicaly the platinum drugs and the subsequent transpupillary thermotherapy was conducted without the use of Wobenzym. In both groups of patients were comparable stages of the process.
In the study group after 6 months of complete tumor resorption with formation of atrophic scar was observed in 4 patients (22%), partial resorption (decrease elevation of the tumor more than 50% of baseline) in 11 patients (61%), stabilization (reduction in tumor size of less than 50% of the tons of original size stabilization or increase its size by no more than 25%)and 3 patients (17%). After 12 months of complete tumor resorption was observed in 15 patients (83%), partial resorption (decrease elevation of the tumor more than 50%) in 3 patients (17%). Residual tumor in 3 patients, amounting to 15-20% of the original, was subjected to laser treatment - transpupillary thermotherapy. In Exodus 3-6 months, there was complete regression of the tumor in all patients.
In the control group after 6 months of complete tumor resorption with formation of atrophic scar was observed in 4 patients (18%), partial resorption of 12 patients (55%), stabilization of the process in 6 patients (27%). After 12 months of complete tumor resorption with formation of atrophic scar was observed in 14 patients (64%), partial resorption, 6 patients (27%), stabilization of the process in 2 patients (9%), progression of the process were observed. Residual tumor in 6 patients, representing up to 15-35% of the original, and in 2 patients, comprising 50-70% of the original, was subjected to laser treatment - transpupillary thermotherapy. In Exodus 5-10 months, there was complete regression of the tumor in 5 patients, partial regression in 3 patients, the progression of the process have been noted.
The clinical result is confirmed by ultrasonographic studies, meet eelistusena about the reduction of acoustic density of the tumor and decrease blood flow to his absence in the study group in the earlier period (up to 6 months), than in the control group. Local and systemic metastasis during the follow-up period of up to 3 years in both groups is not marked.
The study postradiation complications in both groups showed that in the group they were observed in 4 patients (18%): retinovascular -2 (11%), neuromyopathy - 1 (5,5%), neovascular glaucoma - 1 (5,5%). In the control group postradiation complications were observed in 9 (41%) patients: necrosis of the conjunctiva - 1 (4.5%), necrosis of the conjunctiva with subsequent necrosis of the sclera - 1 patient (4.5%), paresis direct muscle - 2 (9%), neuromyopathy - 2 (9%), cataract - 3(14%).
After transpupillary thermotherapy in the study group there were no complications. In the control group was observed complications in 5 patients (62,5%): occlusion of large vessels by mixed type 4 patients (40%), partial hemophthalmus in 1 patient (12.5%).
In clinical studies the effects of Wobenzym when conducting multicomponent conservative treatment of melanoma in fact the choroid installed: strengthening and accelerating the destruction of the tumor, the more rapid the rate of regression of education, fewer complications, improved vital prognosis and quality of life of patients.
All patients reported good tolerability Wobenzym, no allergic reactions, improve well-being.
Bring the clinical examples of the use of the prototype (example 1) and the proposed method (examples 2, 3).
Example 1. Patient Y., 74 years. Diagnosis: Melanoma of the choroid left eye T3N0M0. Ophthalmoscopically in the Central regions of the fundus of the optic nerve - prominere hearth yellowish-grayish color from 12 to 3 hours, with rough surface, single hemorrhages, perifocal retinal detachment. By ultrasound with color Doppler mapping juxtapapillary is determined by the formation of an inhomogeneous structure, with the width of the base of 11.1 mm, prominence 7.0 mm, color flow mapping the flow from low to high, medium and vysokonasyshchennye. Conducted brachytherapy, total focal dose amounted to 132 Gr. 3 months after treatment was noted slabopolozhitelnym dynamics, which is clinically defined as a reduction in tumor size, which was confirmed by the data of ultrasound with color Doppler mapping (education with the width of the base of 9.5 mm, prominence 5.1 mm, your own blood flow is slow, vysokonasyshchennye). 5 months after treatment, the patient developed postradiation cataract that has resulted in a dramatic reduction of vision to the right svetoproektsii and the inability Ophthalmoscope control for uveal melanoma. After 6 months after treatment according to ultra is vukovara research education to its previous size. With organoboranes order was repeated contact transscleral irradiation of uveal melanoma.
Example 2. Patient D., 59 years. Diagnosis: Melanoma of the choroid left eye T3N0M0. Ophthalmoscopically in the lower-outer segment of the eye fundus - exophytic prominere in the vitreous body formation in dark gray with 3 to 6 hours, with rough surface, above it flat retinal detachment. By ultrasound with color Doppler mapping in the lower-outer segment is determined by education moderately heterogeneous echostructure, the width of the base of not less than 11 mm, prominence 8,6 mm, color flow mapping, the blood flow average velocity, srednerazmernyj. Conducted episcleral fixation ophthalmoplegia with a preliminary introduction cisplatin 100 mg with radiomodification purpose, the total focal dose of 128 Grams. Took Wobenzym scheme: up to 2 days before fixation β-applicator 3 tablets 3 times a day for 40 minutes before a meal, during the next 3 months to 5 tablets 3 times a day and the gradual reduction of the dose to 9 tablets per day by the beginning of the 7th month. 6 months after treatment there was a strong positive trend in the reduction of tumor tissue in area and height, the formation of atrophy of the choroid around about the adequate tumor, reduction of retinal detachment. By ultrasound with color Doppler mapping was determined by the formation of a width of the base to 7.8 mm, prominence 2.7 mm, blood in the projection of the focus is on the verge of artifacts. 6 months after brachytherapy held transpupillary thermotherapy for residual tumor and extended the deadline of Wobenzym 3 tablets 3 times a day for 2 months after transpupillary thermotherapy followed by reduction of the dose to 3 tablets every month to prophylactic dose of 1 tablet a day. To prevent the development of metastases taking Wobenzym continued 1 pill 7 days monthly for the first year. 3 months after transpupillary thermotherapy clinically on the background of atrophic scar will be determined in dark gray small prominence lesion with areas of fibroplasia on its surface, retinal detachment no. According to a comprehensive ultrasound examination base width up to 6 mm, prominence 1 mm, the blood flow in the projection of the hearth is not defined. In the period of follow up to 12 months received a complete regression of the tumor, signs of early and late complications were noted. Visual acuity before and after treatment was 0.8.
Example 3. Patient 3., 50. Diagnosis: Melanoma of the choroid right eye T2N0M0. Clinically unstopper the Jarno at the upper boundary of the optic disc ophthalmoscopically gray bumpy education with single point hemorrhages on the surface, above him flat retinal detachment. By ultrasound with color Doppler mapping upwards from the optic disk is determined by education with a wide base of 8-9 mm, prominence 4 mm, height of retinal detachment is up to 1 mm; logged own vessels in the tumor, the blood flow average velocity, srednerazmernyj. Held isolated transpupillary thermotherapy with the prior 2 days taking Wobenzym 3 tablets 3 times a day, then 6 pills 3 times a day for 2 months after transpupillary thermotherapy followed by reduction of the dose to 3 tablets every month to prophylactic dose of 1 tablet a day. To prevent the development of metastases taking Wobenzym continued 1 pill 7 days monthly for the first year. At the control examination after 3 months there is positive dynamics: ophthalmoscopically reduction of tumor size in area and height, the appearance of plots brick color, retinal detachment no. The clinical picture is confirmed by ultrasound - up from the optic nerve education with the width of the base 6 mm, prominence 3.2 mm, the flow on the verge of artifacts. 6 months after transpupillary thermotherapy clinically observed light gray n is large prominence hearth with clear boundaries, according to the integrated ultrasound - prominence is 1.8 mm, the flow is not defined. After 10 months received a complete regression of the tumor. Complications were not observed. Visual acuity before treatment amounted to 0.4 after treatment 0,3.
Thus, the claimed invention is directed to improving the efficiency of multicomponent conservative treatment of uveal melanoma and improving the quality of life of patients by reducing radiation damage.
1. Brovkin A.F., Walski V.V. Gusev, G. and others, the Risk of metastasis of malignant melanoma of the choroid after brachytherapy. // Vestnik of ophthalmology. - 2003. No. 2. - P.26-28.
2. Brovkin A.F., Zaruba GD About the effectiveness of brachytherapy in uveal melanomas.//Ophthalmological journal. - 1993. No. 1. - P.1-4.
3. Volkov V.V. Laser treatment of intraocular melanoma. // Clinical ophthalmology. - 2001. - P.3-7.
4. The Korytov LI, Alekseev, V.N., Ilyin, NV, etc. the Role of radiation therapy in combined treatment of eye diseases. // Clinical ophthalmology. - 2002. No. 4. - 164-168.
Castana the enzyme therapy. A practical guide for physicians. // SPb.: 2001 - P.24-25.
6. Systemic enzyme therapy. Modern approaches and prospects. - SPb.: Non-profit partnership of publishers, St. Petersburg, 1999. - S-156.
7. Daha M.R. Measurement and role of immune complex disease in. J. Int. Fed. Clin. Chem. 5, 5 (1993) 200-204.
8. Licastro F, DavisL.J., Morini L.C., et al. Cerebrospinal fluid of patients with senile dementia of Alzheimer's type shows an increased inhibition of α-chymotrypsin. Alzheimer's disease and Associated Disorders 8, 4 (1994), 241-249.
9. Loetscher H., Steinmetz M., Lesslauer W. Tumor necrosis factor: Receptors and inhibitors. Cancer cells. 3,6 (1991), 221-226.
10. Warshaw A.L., Femandez-Del Castill C. Pancreatic carcinoma. N. Engl. J. Med. 326 (1992), 455-465.
The way conservative treatment of uveal melanoma by multicomponent impact, characterized in that the injected Wobenzym in combination with brachytherapy with radiologicaly and transpupillary thermotherapy or in combination with isolated transpupillary thermotherapy, in the case of brachytherapy with radiologicaly Wobenzym introduce two days before brachytherapy 3 tablets 3 times per day, excluding 8 hours prior to fixing and removing β-applicator, after which the Wobenzym injected from 4 to 6 tablets 3 times a day for 3 months, then reduce the dose to 2 tablets monthly on the 4th, 5-th and 6th months, then 6 months after brachytherapy spend adjuvant transpupillary thermotherapy, and two days before transpupillary thermotherapy Wobenzym impose on 2-3 tablets 3 times a day, and after it within 2 months 4-6 tablets 3 times a day with subsequent dose reduction to 3 tablets every month to prophylactic doses of 1 tablet per day; in the case of an isolated transpupillary thermotherapy Wobenzym impose the same schema is, when adjuvant transpupillary thermotherapy after brachytherapy; to prevent the development of metastasis, as in the case after brachytherapy and transpupillary thermotherapy, and in the case of an isolated transpupillary thermotherapy, the introduction of Wobenzym continue 1 pill 7 days monthly during the first year, and 1 tablet 3 days monthly during the second year of observation.
SUBSTANCE: treatment consists in performing 2-4 courses of preoperative chemotherapy with 2-weak intervals between courses, each course comprising intravenous administration of methotrexate in dose 40 mg/m2 on first or eighth day and intramuscular cyclophosphanin dose 100 mg/m2 during 14 days, while introducing additionally oral Xeloda in dose 1000 mg/m2 twice a day on the first to fourteenth days.
EFFECT: achieved complete regression of tumor focus owing to high selectivity of Xeloda preparation diminishing toxic effect of chemotherapy.
FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to novel C-2'-methylated derivatives of paclitaxel of the formula (I): wherein R represents trifluoromethyl group, phenyl, 2-furyl, 2-thienyl; R1 represents tert.-butoxycarbonyl or benzoyl group; R2 represents hydroxy-group; R3 means hydrogen atom or in common with R2 forms residue of cyclic carbonate of the formula: under condition that when R3 means hydrogen atom then R is not phenyl. Also, invention relates to a pharmaceutical composition based on thereof and using for preparing medicinal agents possessing an antitumor activity. Invention provides preparing novel derivatives of paclitaxel that possess antitumor activity.
EFFECT: valuable medicinal property of derivatives and pharmaceutical composition.
4 cl, 1 tbl, 6 ex
FIELD: organic chemistry, medicine, oncology.
SUBSTANCE: invention relates to derivatives of camptothecin of the general formula (I): wherein R1 represents alkyl or their pharmaceutically acceptable salts. Compounds of the formula (I) are intermediate compounds used in synthesis of camptothecin derivatives that possess anticancer activity.
EFFECT: valuable medicinal properties of compounds.
8 cl, 2 ex
FIELD: chemistry of natural compounds, biotechnology, pharmacology, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to a medicinal formulation of angiogenesis inhibitor comprising active compound as liposome form wherein angiostatin or endostatin are used as an active component, and their truncated peptide fragments also, and an anti-angiogenic pharmaceutical composition used for treatment. Also, invention proposes a method for inhibition of tumor growth and metastasizing of malignant neoplasms associated with disorders in angiogenesis. Method involves administration of nontoxic therapeutically effective dose of pharmaceutical composition separately or in combination with adjuvant therapy with other antitumor preparations. Invention provides reducing rate of elimination of active compound (angiostatin, endostatin or their truncated fragments) from body and enhancing effectiveness of its therapeutic effect. Invention can be used for inhibition of tumor growth and metastasizing of malignant neoplasms.
EFFECT: enhanced and valuable medicinal properties of inhibitor.
7 cl, 3 tbl, 5 ex
FIELD: biopharmacology, preparative biochemistry and medicine.
SUBSTANCE: the method deals with homogenizing mammalian tissues and centrifuging. It is necessary to add ammonium sulfate to supernatant that contains the complex of heat shock proteins (HSP) up to 35-65% saturation, the residue developed should be dissolved in phosphate buffer at pH 7.2 followed by chromatography upon a column with sephadex G-50, then obtained protein fraction should be exposed to the action of chromatography upon heparin-sepharose. Fractions that contain TSP 70, 90, 96 the content of which was detected with the help of corresponding antibodies should be united, concentrated and salted out due to ultrafiltration. The innovation provides more simplified and shortened terms for implementing the method without applying expensive equipment. The complexes obtained should be applied in immunotherapy of oncological diseases.
EFFECT: higher efficiency.
2 dwg, 1 tbl
FIELD: medicine, chemico-pharmaceutical industry.
SUBSTANCE: the present innovation deals with separate introduction of aqueous tincture of shelf fungus, propolis and honey for oncological patients, moreover, shelf fungus should be applied as aqueous tincture at a certain ratio, propolis should be applied as propolis butter, moreover, additionally, one should introduce ursine fat, the tincture of aspen bark, fir oil, fruit juice of viburnum or mountain ash, moreover, patients should take components separately, successively between meals in certain order and certain quantity, moreover, the constituents as tinctures and fruit juices should be prepared just before usage and propolis oil - beforehand. The above-mentioned technique favors efficient treatment of oncological patients.
EFFECT: higher efficiency of therapy.
2 cl, 2 dwg, 4 ex, 1 tbl
FIELD: medicine, oncology.
SUBSTANCE: invention relates to therapy of malignant neoplasms. Method involves administration of ascorbic acid or ascorbic acid glycoside in the dose 50 mg/kg or water-soluble vitamin E in the dose 100 mg/kg. These preparations are administrated simultaneously with sanasol or 30 min before its administration. Method provides decreasing neurotoxicity based on antioxidant and immunostimulating properties of used preparations that are developed in the claimed administration regimen maximally.
EFFECT: improved method for decreasing neurotoxicity.
3 cl, 18 tbl
SUBSTANCE: group of inventions is provided concerning a method of treating a patient with cancer and envisaging administration of chloropromazine and pentamidine simultaneously or consecutively with interval within 14 days in quantities large enough to inhibit growth of the cancer, or in the form of pharmaceutical composition containing indicated agents in quantities, which jointly reduce proliferation of the indicated cancer cells. Pharmaceutical composition itself designed to indicated treatment and pharmaceutical kit are also disclosed. Proposed therapeutical agents separately do not show any antiproliferative effects.
EFFECT: achieved synergetic antiproliferative effect in absence of toxicity regarding normal cells.
17 cl, 1 tbl, 2 ex
FIELD: medicine, in particular oncology and gerontology.
SUBSTANCE: invention relates to foodstuff kit for weekly diet containing (g): dogrose flour 205-210; buckwheat grain 340-350; bran 65-70; green tea 32-35; coarse bread 980-1000; beans 190-200; lentil 190-200; fresh sheetake and mantaki mushrooms 290-300 and desiccated ones 145-150; fresh salmon 290-300; chicken 140-150; onion 190-200; garlic 90-95; carrot 1450-1500; tomato 1450-1500; white cabbage 450-500; sprout 450-500; cauliflower 450-500; broccoli 290-300; red beet 470-500; paprika (red, yellow, green) 340-350; celery 18-20; dill 18-20; parsley 18-20; sagebrush 18-20; bilberry 380-400; grape 380-400; pineapple 2600-2700; papaya 2400-2450; lemon 240-250; orange 260-270; olive oil 340-350. Claimed kit is useful in immunity reducing and increasing of chemotherapy effectiveness.
EFFECT: kit for prophylaxis and treatment of tumor diseases as well as for long-liver nutrition.
FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to benzamide derivatives possessing with inhibitory activity with respect to tyrosine kinase Flt-1-receptors VEGF that can be used in treatment of neoplastic disease. Invention describes a pharmaceutical substance comprising compounds of the group 2-[(4-pyridyl)methyl]-amino-N-[R1]-benzamide wherein R1 means 4-chlorophenyl, 4-methylphenyl, 4-chloro-3-(trifluoromethyl)phenyl or 3-(trifluoromethyl)phenyl possessing with the inhibitory activity with respect to tyrosine kinase Flt5-2-receptors VEGF associated with neoplastic disease and angiogenesis. Also, invention describes novel compounds of the group 2-[(nitrogen-containing heterocycle)methyl]-amino-N-[R1]-benzamide wherein nitrogen-containing heterocycle is represented by 4-pyrodyl, 4- or 5-quinolinyl, 2-imidazolyl, and a method for their synthesis. Also, invention describes a pharmaceutical composition comprising abovementioned compounds possessing the inhibitory activity with respect to tyrosine kinase VEGF receptors used in treatment of neoplastic disease.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
17 cl, 2 tbl, 74 ex
FIELD: medicine, oncology.
SUBSTANCE: one should carry out radiation therapy with quick neutrons 6.3 Mev twice weekly in two stages: at the first stage it is necessary to prescribe 3-4 seances of neutron therapy at interval of 48-72 h directly onto area of tumoral relapse and onto surrounding normal tissues at the distance of about 3-5 cm against tumoral foci, single focal dosage being 1.6-2.0 Gy, relative biological efficiency corresponds to 2.91-2.79, onto the skin - 2.0-2.2 Gy, up to total focal dosage being 6.6±1.5 Gy, onto the skin - 8.3±1.3 Gy, at the second stage it is necessary to carry out gamma- or electronic therapy at single focal dosage being 2.0-3.0 Gy, 5 fractions weekly, moreover, total course dosage of neutron-photon irradiation per a focus corresponds to 60 Gy by isoeffect at duration of irradiation course of about 20-25 d.
EFFECT: higher efficiency of therapy.
2 dwg, 3 ex
SUBSTANCE: assembly can be used for revealing pathologic cells when determining elemental composition of matter from gamma-radiation, for example, from 59Fe isotope stored in mammal gland. Gamma-spectrometry assembly for inspection of mammal gland has patient's chair, collimators, radiation protection, drives for moving chair, spectrometer, ionizing radiation detectors and control board. Collimators are disposed in radiation protection aid and they are made of material which well absorbs ionizing radiation. Collimators are mounted for direction of radiation onto ionizing radiation detectors. Collimators and ionizing radiation detectors are mounted in unit with cavities in form of cups for placing objects to be tested.
EFFECT: improved radiation safety.
2 cl, 3 dwg
FIELD: medicine, ophthalmology.
SUBSTANCE: before the onset of protonotherapy one should surgically withdraw eyelids beyond bony orbital borders for the purpose of complete prevention of complications associated with blepharoirradiation at conducting protonotherapy and creating conditions for the next valuable prosthetics. Thus, after external canthotomy one should make two through vertical incisions of the upper eyelid up to bony orbital border at developing a P-shaped fragment of the upper eyelid, moreover, internal incision should be made about 2-3 mm laterally against the upper lacrimal point, and external one - against internal edge of canthotomic incision. Then one should apply per one P-shaped suture onto both external and internal angles of the fragment, moreover, it is necessary to puncture in needles from cutaneous side of the fragment by applying ligatures in palpebral thickness at capturing a cartilage and perform punctures out into intramarginal space. Similarly, one should apply a single similar P-shaped suture onto the lower eyelid in area of its middle part. The ends of P-shaped sutures should be fixed without tightening frontal and buccal skin, correspondingly. Before carrying out the seance of protonotherapy it is necessary to tighten sutures till eyelids come beyond bony orbital borders, and on finishing the seance of protonotherapy sutures should be weakened till the moment of palpebral juncture.
EFFECT: higher efficiency of prophylaxis.
1 cl, 1 dwg, 1 ex
FIELD: medicine, oncology.
SUBSTANCE: one should carry out morphological testing of therapy results, moreover, in the course of therapy it is necessary to conduct immunohistochemical study for the levels of Ki-67 antigen expression, markers to protein-negative regulator of apoptosis: p53 and Bcl-2 and the level of melanoma marker expression HMB-45 and at decreased levels against the values in untreated tumors it is possible to state upon therapy as efficient. The innovation enables to achieve high clinical efficiency of therapy due to applying neoadjuvant autohemochemotherapy in combination with radiation therapy.
EFFECT: higher accuracy of detection.
SUBSTANCE: method involves applying chemotherapy and/or multi-fraction irradiation daily in two fractions. Variable volume irradiation is carried out during 12 days under radiation dose of 16-20 Gy with dose power being control by means of control unit at the level of 0.18-0.22 Gy/min. Systemic irradiation of tumor dissemination region is carried out with single fraction through a large field. Lymph nodes locally participating into the process and clinically proved lesion foci are irradiated with another fraction after 4.5-6 h long reparation period to total dose equal to 22-24 Gy with unit dose equal to 1.4-1.6 Gy. Medicated sensibilization is carried out during the reparation period.
EFFECT: enhanced effectiveness of treatment; high frequency of no relapse cases.
3 dwg, 1 tbl
FIELD: medical engineering.
SUBSTANCE: device has elongated bioabsorbing carrier containing radioactive sources inside. The sources are separated with spaces. The elongated bioabsorbing carrier is solid composition molded around radiation sources. Moulds are used when producing cells containing radioactive material. A set of radioactive grains is introduced into the mould. Liquid material is introduced into the mould for making it harden. Hardened product is removed from the mould. To treat patients for states manifested as response to radiation therapy, a cell containing radioactive material is arranged in immediate proximity to the patient body zone under treatment for time period required for providing therapeutically effective radiation dose.
EFFECT: produced easy-to-use cell having rigid coating stable in operation.
24 cl, 5 dwg
SUBSTANCE: method involves applying preradiation topometry with irradiation fields being formed. Irradiation is carried out 5 times a week from two opposite fields to reach total radiation dose of 50 Gy under unit focal dose being equal to 2 Gy. The irradiation is applied from rectangular fields having the following boundaries. The lower one is upper edge of the second lumbar vertebra body. The upper boundary is 10 cm higher than the lower one. The right one is 2 cm far from vertebral column contour to the right. The left boundary is 15 cm far from the right one. Removed stomach bed, paracardial lymph nodes, lymph nodes of lesser omentum, gastropancreatic ligament along the left gastric and splenic arteries to the splenic porta and celiac lymph nodes. The tumor propagating over abdominal or supradiaphragmatic esophageal segments, additional anterior and posterior rectangular irradiation fields are formed with paraesophageal and bifurcational nodes being included into the zone.
EFFECT: reduced risk of complications after radiation treatment; maximum amount of healthy tissues retained.
3 cl, 3 dwg
SUBSTANCE: method involves doing surgical intervention including gastropancreaticoduodenectomy with pancreatojejunal anastomosis being created. Small fraction radiation therapy course is preliminarily applied during 3 weeks before operation by treating pancreas projection region and lymph discharge path with gamma-radiation at total dose of 35-40 Gy. Hemcytabine is introduced into gastroduodenal artery at a dose of 0.2 g/m2 in radiopaque oil during operation before carrying out gastropancreaticoduodenectomy.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: method involves administering chemotherapy in 1-5 days long courses. The treatment is accompanied with subtotal patient body irradiation with field concentrated in the area from diaphragm vault to feet everyday once a day before every chemotherapy course. Irradiation dose is equal to 0.1 Gy within total dose of 0.8 Gy. The combined treatment is repeated with 2-3 months long pauses to reach remission or total dose of 1 Sv in subtotal patient body irradiation.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: method involves applying intraoperative radiation therapy with rapid electrons of 6 MeV with single dose of 8 Gray per removed tumor bed. Then, postoperative remote gamma-therapy course is applied after having healed the wound and removing sutures to postoperative suture region and regional lymph discharge zone at a dose of 2 Gray with 5 fractions per week. The number of remote gamma-therapy sessions is calculated from formula N=8.8(3.4-X-0.169), where N is the number of postoperative remote gamma-therapy sessions; X is the time interval length in days between the intraoperative radiation therapy session and remote gamma-therapy session under condition that mixed irradiation dose (intraoperative radiation therapy and remote gamma-therapy) to thyroid gland tumor region or cancer recurrence area is equal to 60 Gray in terms of isoeffect.
EFFECT: increased total course dose per tumor focus; reduced risk of relapse; accelerated treatment course.
FIELD: medicine, ophthalmology.
SUBSTANCE: it is necessary to conduct scanning laser impulse irradiation of newly formed corneal vessels with scattering light bundle for about 5-10 min at applying the following parameters: wave length 890-900 nm, irradiation power 1-5 W in impulse, the frequency of impulses 140-160 Hz and impulse duration 50-300 nsec. Then it is necessary to introduce 0.1-1%-aqueous solution of photosensitizer of khlorin type taken out of the group of photolon, radakhlorin or photoditasin, at the dosage of about 0.8-1.1 mg/kg. Then one should perform exposition of newly formed corneal vessels without light access for about 15-20 min. Then it is necessary to apply the gel based upon hyaluronic acid viscoelastic onto corneal surface, this gel should be chosen out of the group of chealon, viscoate or hyatulon and, moreover, it is important to locate a laser light-scattering device upon corneal surface. Laser irradiation of newly formed corneal vessels should be fulfilled with scattered laser radiation at the density of laser radiation energy being 30-60 J/sq. cm. The innovation provides high efficiency in destructing newly formed corneal vessels followed by technique of optico-reconstructive keratoplasty.
EFFECT: higher efficiency of photodynamic therapy.
1 cl, 2 ex