Method for photodynamic therapy of newly formed corneal vessels

FIELD: medicine, ophthalmology.

SUBSTANCE: it is necessary to conduct scanning laser impulse irradiation of newly formed corneal vessels with scattering light bundle for about 5-10 min at applying the following parameters: wave length 890-900 nm, irradiation power 1-5 W in impulse, the frequency of impulses 140-160 Hz and impulse duration 50-300 nsec. Then it is necessary to introduce 0.1-1%-aqueous solution of photosensitizer of khlorin type taken out of the group of photolon, radakhlorin or photoditasin, at the dosage of about 0.8-1.1 mg/kg. Then one should perform exposition of newly formed corneal vessels without light access for about 15-20 min. Then it is necessary to apply the gel based upon hyaluronic acid viscoelastic onto corneal surface, this gel should be chosen out of the group of chealon, viscoate or hyatulon and, moreover, it is important to locate a laser light-scattering device upon corneal surface. Laser irradiation of newly formed corneal vessels should be fulfilled with scattered laser radiation at the density of laser radiation energy being 30-60 J/sq. cm. The innovation provides high efficiency in destructing newly formed corneal vessels followed by technique of optico-reconstructive keratoplasty.

EFFECT: higher efficiency of photodynamic therapy.

1 cl, 2 ex

 

The invention relates to medicine, namely to methods of photodynamic therapy of newly formed vessels in the cornea.

There is a method of photodynamic therapy of newly formed vessels in the cornea, including the introduction of a photosensitizer in the neovasculature of the cornea and laser irradiation (see Andreyev YU.V. Photochemical destruction of newly formed vessels in the cornea (in the experiment). Abstract of thesis Cand. the honey. of Sciences, Moscow, 1993).

However, the known method when its use has the following disadvantages:

- high phototoxicity used porphyrins,

- high invasiveness and complexity of intravascular injection of the photosensitizer in the newly formed vessels.

The objective of the invention is a method of photodynamic therapy of newly formed vessels in the cornea.

The technical result is the ability to provide high destruction efficiency of newly formed vessels in the cornea followed by the optical reconstructive surgery.

The technical result is achieved by carrying out the destruction of newly formed vessels in the cornea with the use of lower toxicity, bystrovytsia of chlorines in the process of photodynamic therapy. I used the technique of photodynamic therapy makes possible the th of photosensitizer accumulation in endothelial cells of newly formed blood vessels of the retina when intravenous systemic administration. The use of spherical hollow device, the scattering of laser radiation allows 3-5 times to enhance the biological effect of laser irradiation, which in turn reduces the density of the applied laser energy and to avoid unwanted damage to the internal structures of the eye, and the directional impact on the newly formed vessels in the cornea. The basis for this effect is that light-induced chemotherapy. The chlorin photosensitizers number of actively and selectively accumulate in newly formed vessels in the cornea and, if the laser irradiation with a specific wavelength causes the activation of the photosensitizer, which flows induced cytotoxic response in newly formed vessels of the cornea and their destruction.

The method is as follows. Spend a scanning laser pulse irradiation of newly formed vessels in the cornea divergent light beam with a wavelength of 890-900 nm and a frequency of 140-160 Hz for 5-10 minutes at power irradiation 1-5 watts per pulse and its duration 50-300 NS. Then intravenously in one of the cubital vein injected with 0.1-1% aqueous solution of a photosensitizer chlorin number selected from the group Photolon, Radachlorin or photoditazine, at a dose of 0.8-1.1 mg/kg Carry out the exposure of the newly formed is of Asadov cornea for 15-20 minutes without access of light and applied to the surface of the cornea gel-based viscoelastic hyaluronic acid, selected from the group healon, viscoat or gigathlon. Scattering of laser radiation device, made of polytetrafluoroethylene in the form of a truncated hollow sphere, place the truncated part on the surface of the cornea. Conducting laser irradiation of newly formed vessels in the cornea scattered laser radiation with a wavelength of 661-666 nm at energy density of the laser radiation 30-60 j/cm2while laser radiation with a selected density down inside a hollow sphere placed through the hole in the sphere of laser light guide.

Among the essential features characterizing the method of photodynamic therapy of newly formed vessels in the cornea, distinctive are:

- carrying out a scanning laser pulse irradiation of newly formed vessels in the cornea divergent light beam with a wavelength of 890-900 nm and a frequency of 140-160 Hz for 5-10 minutes at power irradiation 1-5 watts per pulse and its duration 50-300 NS,

intravenous introduction into one of the cubital vein of 0.1-1% aqueous solution of a photosensitizer chlorin number selected from the group Photolon, Radachlorin or photoditazine, at a dose of 0.8-1.1 mg/kg,

exposure of newly formed vessels in the cornea for 15-20 minutes without access of light and coating the surface of the cornea of a gel based viscoelastic of hyaluronic acid selected from the group of healon, viscoat or giacolone,

- accommodation on the corneal surface scattering laser device and laser irradiation of newly formed vessels in the cornea scattered laser radiation with a wavelength of 661-666 nm at energy density of the laser radiation 30-60 j/cm2,

- implementation of laser irradiation of newly formed vessels in the cornea scattered laser radiation using a scattering of laser radiation of a truncated hollow sphere made of polytetrafluoroethylene and posted by its truncated part of the cornea, while the laser light with the selected density down inside a hollow sphere placed through the hole in the sphere of laser light guide.

Experimental studies of the proposed method of photodynamic therapy of newly formed vessels in the cornea in a clinical setting showed its high effectiveness of the proposed method. When this was achieved highly efficient destruction of newly formed vessels in the cornea using chlorin photosensitizers series with a low toxicity and is rapidly cleared from the body.

Implementation of the proposed method of photodynamic therapy vascularized corneal leukomas is illustrated by the following clinical examples.

Example 1. Patient W., 26 years who was tupile in the Kaluga branch of IRTC "eye microsurgery" with the diagnosis of post-Traumatic vascularization corneal leukoma right eye". Corneal opacity, size 5 to 7 mm in the paracentral region with capture its Central optical zone with the presence of newly formed vessels.

Conducted photodynamic therapy of newly formed vessels in the cornea.

Spent scanning laser pulse irradiation of newly formed vessels in the cornea divergent light beam with a wavelength of 890 nm and a frequency of 160 Hz for 10 minutes with the power of irradiation 1 W pulse duration of 300 NS. Then intravenously in one of the cubital veins introduced a 1% aqueous solution of a photosensitizer chlorin series, namely Radachlorin, at a dose of 0.8 mg/kg After exposure of newly formed vessels in the cornea for 20 minutes without access of light caused on the surface of the cornea gel-based viscoelastic hyaluronic acid - viscoat. Scattering of laser radiation device, made of polytetrafluoroethylene in the form of a truncated hollow sphere, placed truncated part on the surface of the cornea. Held laser irradiation of newly formed vessels in the cornea scattered laser radiation with a wavelength of 666 nm at a density of laser energy of 30 j/cm2while laser radiation with a selected density summed up inside of a hollow sphere placed through the hole in the sphere of laser light guide.

Achieved full zapustevanie newly formed what's vessels of the cornea, allowing 2 weeks to conduct a successful keratoplasty.

Example 2. Patient C., 42, enrolled in Kaluga branch of IRTC "eye microsurgery" diagnosed with:

"Postinflammatory vascularization corneal leukoma left eye". Corneal opacity, size 4 to 5 mm paracentral with the presence of a rich network of newly formed vessels.

Conducted photodynamic therapy of newly formed vessels in the cornea.

Spent scanning laser pulse irradiation of newly formed vessels in the cornea divergent light beam with a wavelength of 900 nm and a frequency of 140 Hz for 5 minutes when power irradiation 5 watts per pulse and its duration is 50 NS. Then intravenously in one of the cubital veins introduced a 0.1% aqueous solution of a photosensitizer chlorin series, namely photodithazine, at a dose of 1.1 mg/kg After exposure of newly formed vessels in the cornea within 15 minutes without access of light caused on the surface of the cornea gel-based viscoelastic hyaluronic acid - giacolone. Scattering of laser radiation device, made of polytetrafluoroethylene in the form of a truncated hollow sphere, placed truncated part on the surface of the cornea. Held laser irradiation of newly formed vessels in the cornea scattered laser radiation with a wavelength of 661 nm with power supplied energy laser exposed is of 60 j/cm 2while laser radiation with a selected density summed up inside of a hollow sphere placed through the hole in the sphere of laser light guide.

Achieved full zapustevanie newly formed vessels in the cornea, allowing 2 weeks to conduct a successful keratoplasty.

1. The method of photodynamic therapy of newly formed vessels in the cornea, including the introduction of a photosensitizer in the neovasculature of the cornea and laser irradiation, characterized in that conduct scanning laser pulse irradiation of newly formed vessels in the cornea divergent light beam with a wavelength of 890-900 nm and a frequency of 140-160 Hz within 5-10 min of exposure 1-5 watts per pulse and its duration 50-300 NS, then one of the cubital vein injected with 0.1-1%-aqueous solution of a photosensitizer chlorin number selected from the group Photolon, Radachlorin or photoditazine, at a dose of 0.8-1.1 mg/kg, after exposure of the newly formed vessels of the cornea for 15-20 min without access of light applied to the surface of the cornea gel-based viscoelastic of hyaluronic acid selected from the group healon, viscoat or giacolone, placed on the corneal surface scattering of laser radiation device and conducting laser irradiation of newly formed vessels in the cornea scattered laser radiation at a density n is rgii laser radiation 30-60 j/cm 2.

2. The method according to claim 1, characterized in that the laser irradiation of newly formed vessels in the cornea scattered laser radiation is performed with the use of the scattering of laser radiation of a truncated hollow sphere made of fluoroplastic-4 and is placed on its truncated part of the cornea, while the laser light with the selected power down inside a hollow sphere placed through the hole in the sphere of laser light guide.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves exposing the whole ciliary body zone to trans-scleral low intensity laser radiation with wavelength of 633 nm at a dose of 2.5 J or with wavelength of 890 nm at a dose of 1.2 J. Then, chlorine row photosensitizer is injected at a dose of 0.8-1.1 mg/kg and 5 min long pause is made. Ciliary body zones between the direct muscles in four quadrants are exposed to laser radiation 1.5-2 mm far from limb with neighboring fields overlap to 5% of area. Wavelength used for irradiating corresponds to maximum luminous radiation absorption by the photosensitizer. Power density is equal to 50-80 J/cm2.

EFFECT: uniform dosed treatment of ciliary body blood vessels.

FIELD: medicine, ophthalmology.

SUBSTANCE: through paracentesis in limbic area one should introduce into anterior chamber about 0.2-0.3 ml photosensitizing gel based upon hyaluronic acid viscoelastic taken out of the group of chealon, viscoate or hyatulon. The gel contains 0.2-1.0 weight% photosensitizer of khlorin group chosen out of the group of photolon, radakhlorin or photoditasin. Then it is important to conduct exposition of photosensitizing gel without light access for about 20-30 min. Then it is necessary to apply the gel based upon hyaluronic acid viscoelastic (taken out of the same group) onto corneal surface. Then comes transcorneal laser irradiation of anterior ocular segment with scattered laser radiation at the density of radiation energy being 40-60 J/sq. cm. On finishing photodynamic therapy, one should wash out anterior chamber with physiological solution. In the course of the next 48 h a patient should wear special glasses with a light filter for preventing lateral light and removing the light at wave length of above 600 nm, as well. The innovation interrupts inflammatory process and excludes excessive toxic impact upon anterior ocular segment.

EFFECT: higher efficiency of photodynamic therapy.

2 ex

FIELD: medicine, oncology.

SUBSTANCE: one should carry out argon-plasmatic luminal recanalization of trachea and/or bronchi, at power being about 60-90 W followed by conducting brachytherapy at the length of sensor's movement trajectory of about 5-20 cm, at pace of 5 mm and depth of reference isodosage being 10 mm against the sensor. It is necessary to provide applicator's movement being 1-3 cm above and below the tumor at applying the dosage ranged 14-28 Gy once daily per 7 Gy. Then one should fulfill distance radiation therapy 5 times weekly per 1-2 Gy up to TFD being 45-55 Gy. Additionally, before the onset of radiation therapy one should carry out photodynamic therapy with "Photoditasin" preparation at 0.8-1.5 mg/kg and radiation of semiconductor laser at wave length being 662 nm and total dosage of energy being 400 J. The innovation enables to achieve the decrease of tumoral mass, reconstruct the passability of respiratory tract and decrease intoxication and pain syndrome.

EFFECT: higher efficiency of therapy.

3 ex

FIELD: medicine, stomatology.

SUBSTANCE: one should apply "dentin-sealing liquid" consisted of liquid 1 and liquid 2 and, also, additionally, one should apply gradual impact with low-intensity laser radiation upon dentin of prepared carious cavity after each impregnation with "dentin-sealing liquid", moreover, at first it is necessary to impregnate with liquid 2 and then - with liquid 1, then dentin should be again impregnated with liquid 2, moreover, "Aevit" is prescribed, as well. Thus, dentin-sealing liquid activated with laser radiation penetrates dentine canaliculi more deeply and gradual impact prolonged trace effect of laser radiation action.

EFFECT: higher efficiency of therapy.

4 dwg, 1 ex

FIELD: medicine, oncology.

SUBSTANCE: it is necessary to fulfill combined laser and radiation impact due to simultaneous application of laser irradiation for tumoral focus and cancerocidal dosage of roentgenological beams upon low-energetic equipment from the distance of about 7-10 cm at dosage power being 1 Gy/min up to maximal dosage of about 58-62 Gy for about 0.4-3.0 min. Moreover, laser impact should be carried out for 3 min at average power of radiation being 2.4 mW, wave length of 0.662 mcm. The method prevents the onset and the development of radiation-induced lesions in tissue and organs involved into area of radiation impact.

EFFECT: higher efficiency of therapy.

2 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to surgery methods of treatment. Method involves insertion of gel into wound representing a photosensitizing agent comprising 0.5-1.5% of chlorin E6 glucamine salt followed by carrying out treatment of wound by laser in continuous regimen at wavelength 660 nm, energy density supplied to wound 30-40 J/cm2 and power density 0.8-1.0 Wt/cm2. Method provides simplifying, acceleration and enhancing effectiveness of treatment based on using the optimal density of radiation powder. Invention can be used in treatment of spacious suppurative diseases of soft tissues.

EFFECT: improved method of treatment.

3 ex

FIELD: medicine.

SUBSTANCE: method involves performing orbitotomy for excising tumor ad maximum and applying inraoperative photodynamic therapy and chemotherapy. Photosensitizing agent is introduced at a dose of 0.1-1.0 mg/kg of body weight 3 days before the operation. The postoperative cavity formed as a result of operation is filled with physiologic saline immediately after removing the tumor and washing-off the operation wound. Cylindrical diffuser light guide is introduced into the wound and laser radiation treatment is carried out at 670 nm wavelength and power density of 120-800 mW/cm2. The physiologic saline is removed. The light guide is withdrawn. The wound is sutured. Chemotherapy is applied in postoperative period.

EFFECT: enhanced effectiveness of tumor destruction; reduced risk of post-irradiation complications.

5 dwg

FIELD: medicine.

SUBSTANCE: method involves carrying out leukocytic plasmapheresis with at least 100 ml patient blood in two-stage sequential centrifuging at 800 rpm during 10 min and 2000 rpm during 10 min. Antimicrobial preparation is added to autoleukocytes. The autoleukocytes are irradiated with helium-neon laser with 2.2 mW power, wavelength of 0.63 mcm and exposure time of 10 min. The autoleukocytes with the antimicrobial preparation adsorbed thereon are intravenously introduced introduced to the patient every day once a day during 7 days.

EFFECT: enhanced effectiveness of treatment; retained antimicrobial properties with increased adsorption on leukocytes.

FIELD: medicine.

SUBSTANCE: method involves applying diode laser of 980 nm wavelength. Remote action with laser radiation of 20-30 mW is applied to external uterine tube surface for 1-3 min setting the light guide in perpendicular to the surface under treatment. Then, the light guide is introduced into the uterine tube lumen, brought to occlusion place and it is exposed to laser radiation of 300-500 mW with exposure time equal to 30-40 s. After having treated the occlusion place, additional laser radiation treatment is applied to internal uterine tube surface allover its length with power of 20-30 mW during 1-5 min.

EFFECT: accelerated treatment course; complete restoration achieved.

FIELD: medicine, photodynamic therapy.

SUBSTANCE: one should treat affected part with a preparation containing 5-aminolevulinic acid, cover with a light-tight bandage to keep for about 4-6 h. Then comes fluorescent diagnostic survey followed by a 2-fold laser vulval irradiation at the dosage of about 30-75 J/sq. cm at 1-h-long interval that totally corresponds to 100-150 J/sq. cm. The suggested innovation enables to carry out curative process in soft mode, decrease the risk for further development of vulval cancer, achieve healing without any cicatrices and avoid such side effects as phototoxicity.

EFFECT: higher efficiency.

1 cl, 3 ex

FIELD: medicine.

SUBSTANCE: method involves exposing the whole ciliary body zone to trans-scleral low intensity laser radiation with wavelength of 633 nm at a dose of 2.5 J or with wavelength of 890 nm at a dose of 1.2 J. Then, chlorine row photosensitizer is injected at a dose of 0.8-1.1 mg/kg and 5 min long pause is made. Ciliary body zones between the direct muscles in four quadrants are exposed to laser radiation 1.5-2 mm far from limb with neighboring fields overlap to 5% of area. Wavelength used for irradiating corresponds to maximum luminous radiation absorption by the photosensitizer. Power density is equal to 50-80 J/cm2.

EFFECT: uniform dosed treatment of ciliary body blood vessels.

FIELD: medicine, ophthalmology, vitreoretinal surgery.

SUBSTANCE: the suggested device for removing epiretinal membranes contains a hollow handle and a cannula, the working part of which is curved angularly. Cannula's working part ends with a spatula-shaped thickening of 2.5 mm length. Spatula's cross-sectional size doesn't exceed cannula's diameter and contains the rod with a plug-shaped working part. The rod has the chance for reciprocation along cannula's longitudinal axis and for advancing its working part. Working parts of the cannula and the rod are curved at the angle of 115°. As for a handle, it is supplied with a springed up arch-shaped plate. The later is rigidly connected with the rod for its possibility to return into initial position.

EFFECT: higher efficiency of application.

2 dwg, 1 ex

FIELD: medicine, ophthalmology.

SUBSTANCE: the present innovation deals with introducing a biological tissue into Tenon's space, moreover, it is necessary to apply a homotisue of cerebral white substance, it should be taken in a donor not later than 24 h after the onset of clinical lethal. The innovation is directed for the increase of sclerostrengthening effect of operation due to rapid development of fibrous tissue in area of ocular posterior pole in case of introducing bioactive material - homotissue of cerebral white substance.

EFFECT: higher efficiency of operation.

1 cl, 1 ex

FIELD: medicine, ophthalmosurgery.

SUBSTANCE: one should isolate inferior oblique muscle, suture it and dissect it from the site of its fixation. Moreover, at deviation angle being below 35° it is necessary to suture and dissect the part of inferior oblique muscle by exfoliating and isolating its part depending upon the value of deviation angle, and at the angle of 35° it is important to isolate the whole muscle. One should move the isolated muscle or its part to the site of fixation of inferior straight muscle to be sutured. The innovation enables to dose desired effect at different types and degrees of hyperfunction of inferior oblique muscle. Due to transferring the natural site of fixation of inferior oblique muscle or its part from posterior ocular pole being nearer to anterior one the enhancement of inferior straight muscle has been observed.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine.

SUBSTANCE: method involves conducting suture material through wound mouth border and making wound mouth borders juxtaposition by tying thread ends close to skin surface or over washer with following wound draining. When placing the interrupted suture, compression plates are laid over wound mouth adaptation place. The plates are shaped as hexagons, pentagons, rectangles, triangles or squares with rounded angles or circles, ovals or ellipses. The interrupted suture is formed by suturing both wound mouth borders with the thread being drawn through holes in the compression plates and tying knot above compression plate. 1 to 5 different sutures are optionally made with single compression plate. Plates surfaces are covered with aseptic substance. Sutures and plates are taken off gradually at the third-eighth day after operation.

EFFECT: reliable wound mouth fixation; excluded additional cicatrix formation along the main cicatrix line; allowed wound treatment with healing and antiseptic agents.

4 cl

FIELD: medicine, ophthalmosurgery.

SUBSTANCE: the present innovation deals with treating complicated type of strabismus due to simultaneous removing its horizontal and vertical components. Muscle should be divided into 3 parts, one part should be sutured up and dissected at the site of fixation. In case of supravergent vertical component it is necessary to suture up and dissect inferior part of the muscle, and at infravergent vertical component - its upper part. Then one should dissect its middle part, then one should dissect remained one third of the muscle and step against the site of fixation for the length being equal to the distance of dissection in the middle part, and there it is important to fix sutured up and dissected marginal muscular parts together. The innovation provides the chance for simultaneous performance of operation on removing complicated type of strabismus at its horizontal and vertical components, moreover, horizontal component should be removed due to weakening the muscle by carrying out tenomyectomy of its middle part and lengthening the muscle, as for vertical - due to shifting the site of horizontal muscle's fixation upwards or downwards.

EFFECT: higher efficiency of therapy.

FIELD: medicine, ophthalmology.

SUBSTANCE: the present innovation deals with ligating and tightening 4 ocular straight muscles at the site where tendons join eyeball's sclera with nondetachable silk ligatures.

EFFECT: higher efficiency of therapy.

3 ex

FIELD: medicine; ophthalmology.

SUBSTANCE: pincers can be used at fuci-emulsification. Pincers for bending and implanting intraocular lenses has branches with working jaws. Branches are bent along ribs. Working jaws have surfaces for optical part of lens, which are made concave and they have bevels. Bevels are disposed at angle of 2-6° to plane of joint of jaws. Minimal gap between bevels is disposed at external side of bed of working jaws. Minimal length of chord of any concave surface intended for optical part of lens exceeds diameter of optical part of lens by at least 0,2 mm. Minimal sag of any concave surface intended for optical part of lens exceeds average thickness of cross-section of optical part of lens by at least 0,1 mm. Working jaws of pincers interact with flexible (folding) intraocular lenses in optimal manner. Operations can be made through short cut.

EFFECT: reduced traumatism of implantation; comfort at use.

3 cl, 4 dwg

FIELD: medicine, ophthalmology.

SUBSTANCE: one should remove lens due to transciliary lensectomy by keeping anterior lenticular capsule, fulfill vitrectomy, spread retina and block its ruptures; then it is necessary to remove anterior lenticular capsule, implant IOL "Mushroom" through scleral tunnel incision to perform tamponade of vitreal cavity with silicone oil. The innovation enables to decrease irrigational trauma of corneal endothelium and prevent penetration of silicone oil into anterior chamber due to creating temporal barrier out of anterior lenticular capsule during the stages of operation and then constant barrier as IOL "Mushroom". The innovation enables to avoid repeated operations, conduct pupil's enlarging in postoperational period for observing the state of fundus of the eye and shorten terms of patient's functional rehabilitation.

EFFECT: higher efficiency of therapy.

2 ex

Surgical instrument // 2286731

FIELD: surgery; ophthalmology.

SUBSTANCE: surgical instrument can be used for cleaning of internal surface of front and back capsules of crystalline lens. Surgical instrument has handle and working part with edges for rejecting tissues, which are disposed along contour. Working part is made in form of profiled plate with concentric and radial protrusions at opposite sides. Protrusions have additional edges for rejecting tissues. Additional edges have continuous and non-continuous surfaces. Distance between concentric protrusions and distance between radial protrusions at least 1,2 times exceeds height of concentric protrusions and height of radial protrusions correspondingly. Working part is capable of better interaction with surfaces to be treated.

EFFECT: simplified design; maximal comfort at use.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: method involves introducing 0.1-0.3 ml of photosensitizing gel preliminarily activated with laser radiation, after having removed neovascular membrane. The photosensitizing gel is based on a viscoelastic of hyaluronic acid containing khlorin, selected from group containing photolon, radachlorine or photoditazine in the amount of 0.1-2% by mass. The photosensitizing gel is in vitro activated with laser radiation having wavelength of 661-666 nm during 3-10 min with total radiation dose being equal to 100-600 J/cm2. The gel is introduced immediately after being activated. To compress the retina, vitreous cavity is filled with perfluororganic compound or air to be further substituted with silicon oil. The operation is ended with placing sutures on sclerotomy and conjunctiva areas. Compounds like chealon, viscoate or hyatulon are used as viscoelastic based on hyaluronic acid. Perfluormetylcyclohexylperidin, perfluortributylamine or perfluorpolyester or like are used as the perfluororganic compound for filling vitreous cavity.

EFFECT: excluded recurrences of surgically removed neovascular membrane and development of proliferative retinopathy and retina detachment; retained vision function.

3 cl, 5 dwg

Up!