Method for pathologoanatomic diagnostics of acute form of rachitis at intensive keeping technology in gilts

FIELD: veterinary science.

SUBSTANCE: it is necessary to carry out complete dissection of gilts' carcasses to remove organocomplex and investigate vertebral column. Acute rachitis form should be diagnosed by detecting thickenings in intervertebral cartilaginous disks, in thoracic and lumbar departments, particularly. The innovation enables to decrease economical losses.

EFFECT: higher efficiency and accuracy of diagnostics.

2 dwg, 2 ex

 

The invention relates to agriculture, in particular animal - at postmortem and differential diagnosis of non-infectious diseases of pigs.

There is a method that contains the autopsy pigs for fattening, remove organochemical, examination of the costal pleura, discovery leading to chronic rickets pathological signs in the form of thickening of the "rachitic rosary" in the areas of bone and cartilage of the joints of the ribs, as well as softening of the bones, accompanied by the development of an overly large head, short legs, big and flabby "frog" of the abdomen. On the basis of rachitic rosary, softening of bones, changes from parenchymatous organs and intestines known method recommends to differentiate rickets from metabolic vitamin "A" (1).

The disadvantage of this method is that only considered chronic form of rickets, characterized by the above features, which is not fully revealed in the pathogenetic nature of the disease, delayed its timely diagnosis, as well as the development and implementation of therapeutic and preventive measures in terms of technologies of growing animals. Therefore, the changes cannot be adequately transferred to the acute form of rickets.

The aim of the invention is to increase exactly what ti postmortem diagnosis of acute forms of rickets in pigs in the early stages of the disease development in technology-intensive content and thereby reduce economic losses.

This objective is achieved in that after opening the first of the corpses of pigs, the complete removal of organochemical, thorough study of the vertebral table takes into account the specifics of the changes, manifested by thickening of the cartilage intervertebral discs, especially in the thoracic and lumbar regions long before the development of rachitic rosary and visible morphological changes as from parenchymatous organs and intestines.

The specificity of the method for the diagnosis of acute forms of rickets observed during mass diseases and autopsies pigs in conditions of intensive technologies. Subsequently detected characteristic repeatedly refined in laboratory conditions at the Department of pathological anatomy, when the content of the pigs without UV exposure, conducting research and production experiences and at postmortem examination of dead bodies coming from different complexes.

The account of the acute form of the disease and its characteristic clinical and pathological changes increases the efficiency of the pathology and differential diagnosis of rickets in pigs on the material of the opening of the first corpses, allows to develop and implement specific therapeutic and preventive measures, avoiding the deterioration of gain and development is irreversible morphological changes until the mass death of the pigs.

To confirm the specific characteristics represented by two figures, reflecting the essence of the objectives of the invention. Figure 1 shows the clinical manifestation of acute rickets in development of the so-called "hump" at gilt. Figure 2 fixed thickening of the cartilage intervertebral discs from the same pig after opening.

Example 1. In one of the complexes of the Samara region, calculated on a 30-strong herd, at the end of summer in large numbers appeared "humpback" piglets. However, at autopsy, rachitic rosary, and many other signs of rickets (1) as a chronic disease, were absent. Therefore, researchers and staff of many educational institutions are invited for the diagnosis of the disease, it was difficult to determine the true cause of the disease, and some diagnosed even viral infection, type of disease Teschen. The implementation of therapeutic and preventive measures for the appropriate effect was not led until he was diagnosed with acute rickets and not applied to specific treatments. By the end of the third week after ultraviolet irradiation signs of disease in piglets disappeared, they received technological gain.

Example 2. The complex three thousand heads in March among piglets appeared animals with similar characteristics. Manufacturing and district government is the only veterinary diagnosis white-muscle disease. After opening a few dead pigs, diagnosis, organization of walking symptoms began to flatten, and three weeks later disappeared altogether, which confirms the accuracy of diagnosis of the disease.

The materials tested and received a positive evaluation at the international conference, recommended for implementation, and then conducted a study of zoovetservis.com at the international center of retraining and faculty training.

Literature

1. Zharov AV Hypovitaminosis. In the book: Pathological anatomy of farm animals / ALEXANDER Zharov, V.P. Shishkov, M.S., Zhakov, etc. Ed. by V.P. Shishkov, ALEXANDER Zharov. - 4th ed. revised and enlarged extra - M. Kolos, 1999. - S-308 (prototype).

The method of pathological diagnosis of acute forms of rickets in pigs under intensive technologies, including a complete autopsy pigs for fattening, remove organochemical, examination of bone pleura, the discovery of the "rachitic rosary" in the areas of bone and cartilage joints edges, softening of bones, changes from parenchymatous organs and intestines, characterized in that it further examine the spine and severe form of rickets is diagnosed by thickening of the cartilage intervertebral discs in the thoracic and lumbar regions.



 

Same patents:

FIELD: medicine, stomatology.

SUBSTANCE: it is necessary to determine the quantity of dental covering according to dyestuff intensity by a 5-point scale. Bridgework denture should be dyed with certain 0.1%-rhodamine solution. The quantity of dental deposits should be detected due to ultraviolet light spectrum of about 300-400 nm. The innovation enables to detect both the quantity and the quality of dental deposits and evaluate the index of oral hygiene in patients with bridge work dentures, provides dyeing picture in ultraviolet light only and requires no additional washing.

EFFECT: higher accuracy and efficiency of detection.

1 cl, 3 dwg

FIELD: medicine.

SUBSTANCE: method involves carrying out diagnostic examination of ophthalmic diseases. Health state of organism systems and organs is additionally estimated. Systems and organs having deviations from norm are selected and bound to channels P, RP, C, R, F. Actions are applied by showing images to patient. Image colors exert curative action in accordance to color tables of Ancient China philosophy and WU-SING doctrine. The color exerting curative action upon a channel is selected to be the same with the color exerting curative action upon organ belonging to the channel. Detected pathologically changed organ or system is acted during the first treatment course. The channel having the detected pathologically changed organ or system, is treated at the second treatment course. The following treatment courses deal with the channels conjugated to the first one corresponding to WU-SING doctrine. The total treatment per each organ or system and each channel course is 10 procedures long.

EFFECT: enhanced effectiveness of treatment with the whole organism state taken into consideration.

1 dwg, 7 tbl

FIELD: medicine, cardiology.

SUBSTANCE: one should carry out discriminant analysis to create discriminant function with coefficients of independent variables, such as: arterial hypertension, anemia, gynecological disease, hyperglycemia, cholelithiasis, smoking, lipid disorders, pathological menopause, excessive body weight and thyroid diseases. It is necessary to evaluate every risk factor and solve the function. At the value of function being above 1.710 one should predict the absence of atherosclerotic lesion of coronary vessels. The innovation enables to establish the probability of atherosclerotic lesion of coronary vessels or its absence according to risk factors in female patients due to carrying out discriminant analysis.

EFFECT: higher accuracy of prediction.

3 ex

FIELD: medicine, photodynamic therapy.

SUBSTANCE: one should treat affected part with a preparation containing 5-aminolevulinic acid, cover with a light-tight bandage to keep for about 4-6 h. Then comes fluorescent diagnostic survey followed by a 2-fold laser vulval irradiation at the dosage of about 30-75 J/sq. cm at 1-h-long interval that totally corresponds to 100-150 J/sq. cm. The suggested innovation enables to carry out curative process in soft mode, decrease the risk for further development of vulval cancer, achieve healing without any cicatrices and avoid such side effects as phototoxicity.

EFFECT: higher efficiency.

1 cl, 3 ex

FIELD: medicine.

SUBSTANCE: method involves determining preoperative factors like clinical stage of prostate neoplasm, prostate-specific antigen level, prostate capsule invasion with tumor from rectal finger palpation test data, prostate capsule invasion with tumor from transrectal ultrasonic examination data, the number of positive biopsy bars in carrying out transrectal prostate biopsy, neoplasm differentiation stage from transrectal ultrasonic examination, malignance degree from transrectal ultrasonic examination according to Glisson scale. Histological examination results are evaluated after previously done transurethral prostate resection. Postoperative factors like pathological neoplasm development stage, malignance degree from morphologic examination data according to Glisson scale and prostate tumor invasion into seminal vesicles from morphologic examination data are also determined. Remote metastasis index is calculated from formula M=0.24xT - 0.010xP + 0.87xR + 0.02xC + 0.15xB - 1.12xD + 0.07xKG + 0.38xH - 0.38xpT + 0.11xPG + 2.02xV, where M is the remote metastasis index, T is the clinical prostate neoplasm stage: 1 - T1; 2 - T2; 3 - T3; P is the prostate-specific antigen level before operation in ng/ml; R is the prostate capsule invasion with tumor according to rectal finger palpation test data: 0 - no invasion; 1 invasion available; C is the prostate capsule invasion with tumor according to transrectal ultrasonic examination data: 0 - no invasion; 1 invasion available; B is the number of positive biopsy bars in carrying out transrectal prostate biopsy: 1-6; D is the neoplasm differentiation stage from transrectal prostate biopsy: 1 low level differentiation degree;2 - moderate level differentiation degree; 3 - high level differentiation degree; KG is the malignance degree according to transrectal prostate biopsy data using Glisson scale 2-10; H is the histological examination after previously done transurethral prostate resection: 0 - not applied; 1 - benign prostate hyperplasia; 2 - prostate adenocarcinoma; pT is the pathological neoplasm development stage: 1 - pT2a; 2 - pT2b; 3 - pT3a; 4 - pT3b; PG is the malignance degree from morphologic examination data according to Glisson scale: 2-10; V is the prostate tumor invasion into seminal vesicles from morphologic examination data: 0 - no invasion; 1 invasion available; and if M>-1.55, remote metastasis formation is predicted.

EFFECT: high accuracy of prognosis.

1 tbl

FIELD: medicine.

SUBSTANCE: method involves carrying out chronobiological studies in morning, day and evening hours. 9-11 measurements are taken for studying intraocular pressure values with 1-2.5 h long pauses during 4-5 days with 2-3 different measurements in succession falling on each day.

EFFECT: high accuracy of diagnosis.

2 tbl

FIELD: medicine.

SUBSTANCE: method involves determining concentrations of carcinogens like aniline, toluyline, diethyl alanine, diphenyl and 1-naphtholamine in urine and urodynamic disorders and proliferative urothelium activity from Ki-67 expression degree data. High carcinogen concentrations and urodynamic disorders being detected apart from the fact of tumor removal and unchanged mucosa biopsy, transurethral prostate resection or urinary bladder neck resection is carried out. Next, liquid consumption increase in postoperative period and carcinogen contact reduction are advised. Three months later, control study is carried out. Carcinogen concentration level remaining high and no proliferative urothelium activity reduction being observed on the background of urodynamic disorders, cystectomy is to be repeatedly carried out.

EFFECT: enhanced effectiveness of treatment; high accuracy of diagnosis.

FIELD: medicine, diagnostics.

SUBSTANCE: due to spectrophotometry on should study body biological material to detect the concentration of porphyrin in tissues of biological material and compare it values against the standard. As biological material one should apply that part of the tissue at patient's body where spectrophotometric investigation should be carried out in vivo. Moreover, One should affect this part with low-intensity laser radiation, wave length corresponds to one of the maximums of protoporphyrins' absorption range. One should determine the amplitude of fluorescence radiation of this part. As a standard for comparison one should take the amplitude of fluorescence of protoporphyrin IX that models the concentration of protoporphyrin in blood erythrocytes ranged 100-1500 mcg/l and more. At equality of amplitudes it is necessary to establish concentration of proptoporphyrin IX in blood erythrocytes of biological tissue under testing. Moreover, wave lengths corresponding to maximums of absorption range of protoporphyrins correspond to 337, 370, 405, 532, 632 nm. The innovation enables to considerably simplify the investigation of values that indirectly characterize lead concentration in tissues and, thus, total degree lead intoxication in patients with the risk of lead intoxication.

EFFECT: higher efficiency of diagnostics.

1 cl, 1 ex

FIELD: medicine, oncology.

SUBSTANCE: one should carry out immunohistochemical and morphological tumoral study. At values of antigen KI-67 expression level being below 10%, mutated gene-suppressor P53 being below 10% and mitotic activity in the tumor being below 10 mitoses per 10 vision fields one should predict favorable prognosis of the disease. At values of Ki-67 being above 10%, P53 being above 10% and mitotic activity in tumor being above 10 mitoses per 10 vision fields one should predict unfavorable prognosis of the disease in question. The innovation enables to obtain quantitative objectivity of the results achieved.

EFFECT: higher accuracy of prediction.

1 dwg, 2 ex

FIELD: medicine, traumatology.

SUBSTANCE: the present innovation deals with providing individual approach in necessity to prescribe the course of HBO in patients with acute ischemia of limbs after fractures of long bones. One should detect partial pressure of gas in tissues of an affected limb before HBO seance, moreover, it is necessary to detect partial pressure of carbon dioxide due to noninvasive technique being distally the lesion level both before and 3 h after a pilot HBO seance to compare their values and at availability of the increase in the values of partial pressure of carbon dioxide in tissues against the values before HBO seance by 30 mm mercury column, and more one should conclude upon the usefulness of carrying out the course of HBO therapy.

EFFECT: higher accuracy of detection.

2 ex

FIELD: medicine, clinical toxicology.

SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: method involves studying blood samples with venous blood mixed with vital stain like methylene blue. Degree of vital stain absorption by erythrocytes is determined by applying photocolorimetry. The value drop being more than 25%, extracorporal detoxication is to be predicted as ineffective.

EFFECT: simplified method.

6 tbl

FIELD: medicine.

SUBSTANCE: method involves evaluating prognostic signs and calculating their prognostic weight. Consciousness disorders and diagnosis set at prehospital stage are used as the prognostic signs. Calculations are carried out from formula: lethal outcome %= -15.99+19.1•C+14.7•DS-2.79•C•DS, where C is the ranged consciousness disorder degree, DS is the diagnosis set prehospital stage. The higher is the value, the higher is lethal outcome probability.

EFFECT: accelerated and simplified prognosis method.

FIELD: medicine.

SUBSTANCE: method involves evaluating proliferating processes by calculating index of positive cell nuclei (Ki-67). The Ki-67 value being from 6 to 16%, erosive ulcerating stomach lesions accompanied by stomach hemorrhage and hemorrhagic shock is to be predicted. The value being from 17 to 30%, erosive ulcerating stomach lesions without hemorrhage is to be predicted.

EFFECT: high accuracy of prognosis.

1 tbl

FIELD: medicine, urology.

SUBSTANCE: the present innovation deals with differential diagnostics of prostatic cancer and other prostatic diseases at the stage of primary inspection. The method includes the detection of PCA and calculation of probability coefficient for prostatic cancer (PCC) by the following formula: where e - the foundation of natural logarithm (e=2.718…), PCA - the level of total blood PCA in ng/ml, V - patient's age in years. At PCC value being above 0.2 one should diagnose prostatic cancer and to establish final diagnosis one should perform polyfocal prostatic biopsy. The method enables to increase accuracy of diagnostics at decreased number of unjustified prostatic biopsies.

EFFECT: higher efficiency of diagnostics.

2 ex

FIELD: medicine.

SUBSTANCE: method involves determining homeostasis values and absolute number of neutrophils and lymphocytes in particular. Low neutrophil number being determined in a child during a number of years and low number of lymphocytes in the persons from the nearest child surrounding, the persons are to be examined for given psychosomatic pathology availability with following medical treatment to be applied to eliminate the detected pathology and to normalize homeostasis values and lymphocyte number among others.

EFFECT: enhanced effectiveness of prophylaxis.

FIELD: medicine.

SUBSTANCE: method involves measuring radio signals and low frequency spectra of signals emitted by oral cavity organs and tissues in maxillofacial area. Decoding and comparison of the spectra to healthy organs and tissues spectra is carried out. Then, modulated information signals in infra-low frequency bandwidth corresponding to healthy organs and tissues signals are applied. Low frequency radio signals and spectra are measured. Treatment with modulated signals in infra-low frequency bandwidth is applied directly to organ or its location zone via skin.

EFFECT: enhanced effectiveness in diagnosing and treating oral cavity organs and tissues in maxillofacial area.

5 cl, 3 tbl

FIELD: medical engineering.

SUBSTANCE: device has bottom and cover joined in inseparable way so that no chance is available to mismatch covers belonging to different containers. The bottom and internal part of cover are lined with sponge so that the allergenic disks are kept in uniformly wetted state. Grate with holes is attached to lower sponge, the holes narrowing downward as cones so that the allergenic disks are kept in stable vertical position.

EFFECT: simplified access to disks using forceps; excluded misidentification risk.

5 cl, 6 dwg

FIELD: medicine, operative gynecology.

SUBSTANCE: at final stage of laparoscopic operation for 5-7 min one should introduce 16 U lidase in 1 ml 2%-lidocaine solution into uterine mesentery from both sides, and then, by not removing a needle - a half of single dose of antimicrobial preparation in 1 ml 2%-lidocaine solution, then in postoperational period - an antimicrobial preparation applied during laparoscopy lymphotropically under mucosa of lateral vaginal arch from both sides for 5-7 d once daily and one antimicrobial preparation - intravenously for 5-7 d, moreover, as antimicrobial preparations one should apply gentamicin, metrogyl and other preparations permitted for intravenous application. The present innovation stimulates lymphatic drainage in area of inflammation and activates interstitial humoral transport of antimicrobial preparations that, in its turn, favors complete sanitation of inflammation foci and prophylaxis of disease relapses.

EFFECT: higher efficiency of therapy.

1 cl, 1 ex

FIELD: medicine.

SUBSTANCE: method involves applying biological indicator as mixture composed of 0.1% aqueous solution of amino acids: leucine, glycine, proline, serine, phenylalanine, histidine, oxyproline, arginine, glutamic amino acid and aspartic amino acid, 0.5% aqueous solution of neuromediators like dopamine and histamine, 12% aqueous solution of magnesium sulfate in proportion of amino acids : neuromediators : magnesium sulfate = 4:1:5. Indicator kept on neck surface in thyroid gland projection during 3-5min. It is dried at T=+35-40°C, studied in polarized light with quartz compensator. Columnar, columnar-and-striated, sheaf-like crystals and discharged polygonal variegated chambers being observed, thyroid gland hyperfunction is to be diagnosed.

EFFECT: high accuracy of diagnosis.

13 dwg

Up!