Ointment for topical application

FIELD: pharmaceutical industry, in particular analgesic, vasodilatation, anti-inflammation ointment for topical application.

SUBSTANCE: claimed ointment is prepared in form of fine dispersed formulation containing bee venom extract melittin, lavender oil, camphor, arnica tincture, rosemary oil, eucalyptus oil, revitalin, carbopol, 30 % solution of sodium hydroxide, hydrophilic anionic ointment, soy lecithin, glycerol, conserving solution, ethanol, distilled water.

EFFECT: reduced toxicity of bee venom, decreased side effects and improved therapeutic effect.

2 tbl, 3 ex

 

The invention relates to medicine, namely to the pharmacy, and for the composition of ointments for external use.

In medicine it is widely known compositions for the treatment of patients with rheumatism, diseases of the muscles and joints, hypertension, nonspecific polyarthritis, myositis, lumbosacral radiculitis, sciatica, neuralgia, polyneuritis, myalgia, such as rubbing the mixture diet" and other compositions containing snake and bee venoms "Vibratex", "Wipein", "Apistan". The disadvantages of the compositions containing snake and bee venoms are high idiosyncrasy, a large number of contraindications.

Closest to the claimed composition on the achieved result is the ointment "Viprosal"containing poison lebetina Viper, camphor, salicylic acid, pine oil, petrolatum, glycerin, paraffin wax, emulsifier and water. However, in view of the fact that the poison lebetina Viper is a coagulant (a substance that increases blood clotting), the disadvantages of this drug may include a narrow therapeutic range - the difference between safe and toxic doses; use vaseline, which forms on the skin of a thin film, making it difficult to penetrate in the blood of active medicinal substances; frequent individual intolerance of the drug, manifested in the form of nausea, vomiting, malaise, chills, increasing the temperature, edema, urticaria, pain in the lower back and joints, seizures, syncope States and other in Addition, the drug has numerous contra-indications - diseases of the kidneys, liver and pancreas, diabetes, cancer, tuberculosis, severe infectious diseases of the haematopoietic system, circulatory failure, etc.

The technical result achieved thanks to the creation of the present invention is to obtain an effective analgesic, vasodilatory and anti-inflammatory drug on the basis of the components of bee venom, with improved tolerability and fewer side effects by reducing the toxicity of bee venom by removing fractions, causing adverse reactions. The ointment can be applied to ensure, in particular, patients with rheumatism, diseases of the muscles and joints, hypertension, nonspecific polyarthritis, myositis, lumbosacral radiculitis, sciatica, neuralgia, polyneuritis, myalgia, and many other diseases.

The delivered result is achieved by creating ointment analgesic, vasodilatory, anti-inflammatory composition as a main component includes extract of bee venom - melittin, camphor, tincture of Arnica, lavender, rosemary and eucalyptus oils, revitalin, who as a helper - the carbopol, 30% sodium hydroxide solution, ointment hydrophilic anionic, soy lecithin, glycerin, preservative solution, distilled water and ethyl alcohol, in the following ratio of components in g per 100 g of product:

Extract of bee venom - melittin
(Apis mellifera toxin)0,003÷0,010
Lavender oil (Aetheroleum lavandulae)1,0÷5,0
Camphor (Camfora)3,0÷5,0
The Arnica tincture (Tinctura amicae)2,0÷7,0
Rosemary oil (Aetheroleum rosmarinus)1,0÷5,0
Eucalyptus oil (Aetheroleum eucalyptus)1,0÷5,0
Revitalin (Revitalin)1,0÷3,0
The carbopol (Carbopol) (934 or 940 or 941)0,99÷1,1
Of caustic soda solution of 30%
(Natrium hydroxid 30%)0,99÷1,1
Ointment hydrophilic anionic
(Natrium laurylsulfuricum,
Alkoholum cetylstearilicum,
Paraffinum liguidum,
Vaselinum album)19,9÷20,1
Soy lecithin (Lecitinum)0,2÷0,4
glycerin (Glycerinum) 6,0÷10,0
Preservative solution
(Methylparahydroxybenzoicum)0,9÷1,1
Ethyl alcohol (Alcoholum 96%)1,2÷1,5
Distilled water
(Aqua destillata)Rest

The proposed ointment on physico-chemical properties is a homogeneous fine product from white to light yellow color with a smell of camphor and lavender. The key ingredient is the extract of bee venom - melittin. It has anti-inflammatory, analgesic effect. In addition, it will expand the cerebral vessels and the coronary vessels, stimulates the pituitary-adrenal system. Camphor - medicinal substance from the group of stimulants nervous activity. When skin is well absorbed, has a local irritant effect, and has antiseptic and insecticidal properties. Tincture of Arnica - drug irritant, anti-inflammatory, antibacterial action. Contributes to the formation and release of physiological stimulators of immunological processes, activates local blood flow, accelerates resorption of hemorrhages. Lavender, rosemary, who evkaliptowoe oil affect the receptors in the skin, accompanying the release of endorphins and other substances that regulate pain sensitivity and vascular permeability. Possess analgesic and anti-inflammatory effects. Revitalin causes a significant increase in skin temperature, increases blood flow to the depth of the muscles, which promotes better penetration of the blood of active components of the drug. The carbopol is carboxyaniline polymer. It is used for preparation of the suspension. Ointment hydrophilic anionic, caustic soda solution of 30%glycerol part of the fine ointment bases. Soy lecithin contains total phospholipids contributes to the development of the body, enhances physical and mental ability, accelerates the recovery of the body after a great effort. Has the ability to penetrate deeply into the skin. The preservative solution is used as an inhibitor of oxidation during prolonged storage. Ethyl alcohol (96%) is a multifunctional component of the drug. Has good dissolving capacity. In addition, when applying ointment to the skin it promotes deeper penetration of the components with the simultaneous release of heat (heating the surface of the body).

Testing therapeutic composition of ointments as an anaesthetic was held at the Moscow Institute of atradition the x treatment methods and the laboratory of clinical pharmacology and doping control MNPCS.

At the Moscow Institute of non-traditional methods of treatment of drug composition was used as an external tool by rubbing in the area of pain with a layer of approximately 1-2 mm depending on the intensity of pain during the procedure was repeated up to 3 times a day. With good treatment outcome was no pain, improved overall health, normalizability sleep had smoothed out or disappeared neurological symptoms. If a satisfactory outcome of treatment decreased pain and objective symptoms. In the absence of dynamics in the subjective and objective data, the treatment results were evaluated both with no effect. As can be seen from table 1, the total number of patients who were treated with the proposed drug, 48.6 per cent obtained a good result, 44,3% - satisfactory, at 7.1 percent, the effect was not observed. Thus, the effectiveness of the treatment claimed by the drug made up 92.9%.

In the laboratory of clinical pharmacology and doping control MNPCS the aim of the study was to assess the effectiveness of the drug in the practice of sports medicine. The studies were performed on athletes, edge-runner mills middle distance with traumatic lesions of tissues and musculoskeletal system (light and moderate) of the lower extremities.

The total number of subjects: 30.

The control group (10 is artsimenov) did not apply the ointment.

Qualification: msic-6, MC-12, kms-12.

Age: from 18 to 28 years.

In accordance with the conditions for all the subjects at the beginning and end of the experiment (1st and 20th days) passed comprehensive testing and medical examination, and 5 days after cessation of use. The overall health of the athletes was evaluated by performing the ultimate muscle work speed increasing nature to "opt-out" Jogging on redbana "Quinton" (USA). Among the biochemical parameters were carried out observations on the concentration of urea, lactate, glucose, protein in the blood by conventional methods. The effects of the claimed ointment on physical performance are presented in table 2 (% to control).

Conclusions MNPCS:

- the claimed ointment in exchange application within 20 days restores the overall sports performance athletes;

- identified the antioxidant activity of the drug in the same time frame;

- any side effects (allergic reactions, pain, prolonged redness, itching, swelling), as well as negative organoleptic properties of the drug was not detected;

- the drug is not detected doping drugs and their metabolites;

the drug can be recommended in sports medicine practice.

The effectiveness of the home the military ointment as a vasodilator of the following examples.

Example 1. Patient X, 60.

Was in therapeutic Department of the City clinical hospital №70 of Moscow in the autumn of 2005.

Diagnosis: chronic obstructive bronchitis in the acute stage. Coronary heart disease: Atherosclerotic cardiosclerosis. Varicose veins of both legs. Venous insufficiency stage 2.

Complaint: shortness of breath, dry rales, edema of the feet of both legs, trophic ulcer of the right big toe of the left foot, the big toe of the left foot.

Objectively: the state of moderate severity. Dry, wheezing in the area of the mediastinum. Hypersthenics. Shin pasty, varices on both sides, was more expressed on the left leg. Feet swollen, centioni. On the left foot big toe trophic ulcer, 0.5×1 see

Rheography of the lower extremities. Eographically index (RI) is reduced to 0.5 cm, the volume is reduced. Obstructed venous outflow.

Appointed: rubbing the claimed ointment five times a day in the feet and legs under control prothrombinase index and rheography.

On day 5 of treatment slept swelling of the feet, practically disappeared zianoticnae.

Rogramme lower extremities. RI increased to 1.0, the Volume increased by 30%, improved venous return and vascular tone. Prothrombin 95%.

On the 15th day of treatment: the skin of the lower limbs supple, regular color. raznye nodes slept. Prothrombin 85%. Ulcer epithelials. On rogramme: RI-2,0. The pulse wave has increased to 2.5, see

Example 2. Patient Y, 52.

Was in the seventh division of Infectious clinical hospital No. 1, Moscow in the autumn of 2005.

Diagnosis: bronchial asthma, lung during (not hormone-dependent). Influenza (NF+) average for; was admitted with complaints of weakness, fever up to 38°, sweating, shortness of breath.

History: acutely Ill in October 2005, the temperature Rose to 38.2°C. it Became difficult to breathe. Was treated symptomatically: breast collection, aminophylline, 1 I.×3 times a day. No improvement occurred. Went to the polyclinic hospital in IKB No. 1-7 CTD.

Fluoroscopy. Signs of pneumosclerosis: roots extended; the bronchial tree with the sign of obstruction. Blood test: HB-12, 0mm, L-5,6, er-5,02, p-8, C-60, e-2. ESR-8 mm/h

At the first stage of treatment, along with the usual regimen added therapy ointment claimed composition through its rubbing on the front surface of the chest 3 times a day and the back surface 2 times a day. On the 5th day of treatment due to the significant improvement of respiratory functions have ceased shortness of breath returned to normal body temperature to 36.5°With, decided to continue treatment with the ointment of the claimed composition with the complete abolition of previous drug therapy. Treatment ointment lasted 15 is it.

Chest x-ray after the procedure: bronchopulmonary tree almost completely organised, hemodynamics in a small circle is normalized, left signs of overload of the right ventricle. Blood urine from 29.10 without pathology.

The efficacy of the claimed ointment as anti-inflammatory agents is confirmed by the following.

Example 3. Patient Z, 28 years.

Was in October 2005 in the second traumatological Department of the Moscow Scientific and practical center of sports medicine.

Admitted with complaints of pain in the right knee, his swelling, inability to move freely, dragging pain in the lumbar spine with irradiation in the right lower limb.

History: up to 25 years actively involved in sports - backup team "Dynamo" (Moscow). Repeatedly treated about the various injuries of the lower extremities (broken ankle left ankle in 2002). In October 2005 during the Amateur game in the clash fell sharply on the right half of the body. Treated independently: compresses, analgesics without any visible effect.

Objectively: the Right knee swollen, deep palpation is painful. The movement in it is saved, but limited.

Fluoroscopy: crack lateral edge of the patella, congestion is E. synovial fluid in the cavity of the articular capsule

Ultrasound: the material tears of ligaments.

Diagnosis: traumatic arthritis of the right knee joint, lumesule.

The Department actively pursued a course of treatment with the ointment of the claimed composition or three times a day application area of the paravertebral joint and departments, as well as electrophoresis with ointment of the claimed composition in the lumbar region and right knee joint through the day. On day 2 of therapy significantly weakened pain syndrome, on the 4th day gone swelling of the joints. On the 10th day full recovery of motor activity of the joint.

X-ray after treatment: no visible change to the patella.

Discharged with good effect held treatment.

Table 1
NameThe number of patientsSignificantImprovementWithout changeDeterioration
diseasesimprovement
Rheumatoid arthritis201271-
Rheumatic15861-
arthritisÈA;
Deforming205132-
osteoarthritis
Neuralgia15951-
myositis
Total: absc7034315-
%10048,644,37,1-

Table 2
GroupInitial stateOn the 20th day5 days after receiving
Healthy athletes100,2of 99.1100,3
Control79,383,194,9
Experiment75,4119,1102,4

Ointment obezbolivaushee, vasodilator, anti-inflammatory, containing extract PCLI the CSOs poison - melittin, camphor, tincture of Arnica, lavender, rosemary and eucalyptus oils, revitalin, carbopol, 30%sodium hydroxide solution, ointment hydrophilic anionic, soy lecithin, glycerin, preservative solution, distilled water and ethyl alcohol, in the following ratio of components, g per 100 g of product:

Extract of bee venom - melittin
(Apis mellifera toxin)0,003÷0,010
Lavender oil
(Aetheroleum lavandulae)1,0÷5,0
Camphor (Camfora)3,0÷5,0
Tincture of Arnica
(Tinctura arnicae)2,0÷7,0
Rosemary
(Aetheroleum rosmarinus)1,0÷5,0
Eucalyptus oil
(Aetheroleum eucalyptus)1,0÷5,0
Revitalin (Revitalin)1,0÷3,0
The carbopol (Carbopol)
(934 or 940 or 941)0,99÷1,1
Of caustic soda solution of 30%
(Natrium hydroxid 30%)0,99÷1,1
Ointment hydrophilic anionic
(Natrium layrylsulfuricum,
Alkoholum cetylstearilicum,
Paraffinum liguidum,
Vaselinum album)19,9÷20,1
Soy lecithin (Lecitinum)0,2÷0,4
Glycerin (Glycerinum)6,0÷10,0
Preservative solution
(Methylparahydroxybenzoicum)0,9÷1,1
Ethyl alcohol (Alcoholum 96%)1,2÷1,5
Distilled water
(Aqua destillata)Rest



 

Same patents:

FIELD: organic chemistry, medicine, veterinary science, pharmacy.

SUBSTANCE: invention relates to derivatives of tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridine of the formula (1): , wherein R3 means oxygen atom or absent; R8 is chosen from: (a) hydrogen atom; (b) (C1-C3)-alkyl that can be unsubstituted or substituted with 1-6 fluorine atoms; (c) -O-(C1-C3)-alkyl; (d) fluorine atom, and (e) hydroxy-group, and their pharmaceutically acceptable salts and separate diastereomers. These compounds are modulators of activity of chemokine receptors. Also, invention relates to a pharmaceutical composition based on compounds of the formula (1), method for modulation of activity of chemokine receptors in humans and animals and a method for preparing a medicinal agent. Invention provides preparing novel modulators of chemokine receptors activity.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

8 cl, 13 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of 2-phenylaminoimidazoline phenylketone that can be used as IP antagonists. Invention describes 2-phenylaminoimidazoline phenylketone of the general formula (I): wherein R1 mean optionally substituted aryl wherein R1 is optionally substituted with 1, 2 or 3 substitutes chosen independently from series including alkoxy-group, aryl aryloxy-, aralkyloxy-group, halogen atom, ethylenedioxy-group or optionally substituted heterocyclyl that means a monovalent saturated carbocyclic radical comprising from 3 to 7 atoms in cycle and comprising one or two heteroatoms chosen independently from nitrogen and oxygen atoms, and can be optionally substituted with one or more substitutes chosen independently from alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkyl sulfonyl, furanyloxy-group; R2 means hydrogen atom; A means -C(O)-(CH2)n- or -C(O)-CH2-O-; index n means a whole number from 2 to 6, or its pharmaceutically acceptable salt or solvate. Invention provides preparing novel compounds showing useful biological properties.

EFFECT: valuable properties of compounds.

16 cl, 1 tbl, 23 ex

FIELD: pharmaceutical industry, in particular cyprofloxacine solution.

SUBSTANCE: claimed solution contains cyprofloxacine hydrochloride, sodium salt of ethylenediamine-N,N,N1,N1-tetraacetic acid, α-hydroxypropionic acid, sodium chloride, water for injections.

EFFECT: drug of increased biological availability without side effects.

3 tbl

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of amide of the general formula (I)

wherein X means -CH; Y means -CH or nitrogen atom (N); m = 1 or 2; R1 means (C1-C6)-alkyl, (C1-C)-alkoxy-group, N,N-di-[(C1-C6)-alkyl]-amino-group, heterocyclyl-(C1-C6)-alkyl wherein heterocyclyl represents piperazinyl or homopiperazinyl; n = 3; R2 means halogen atom, (C1-C6)-alkyl; R3 means hydrogen atom; Q means phenyl optionally substituted with cyano-group, or pyridyl optionally substituted with morpholino-group, or their pharmaceutically acceptable salts, to methods for synthesis of indicated compounds, pharmaceutical compositions containing thereof and their using in treatment of diseases or states mediated by cytokines.

EFFECT: improved preparing methods, valuable medicinal properties of compounds and pharmaceutical compositions.

10 cl, 2 tbl, 7 ex

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing modified glycosaminoglycans possessing analgesic properties. Method involves interaction of glycosaminoglycans with 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminoantipyrine) in aqueous medium at pH = 4.7-4.8 in the presence water-soluble 1-ethyl-3-[3-(dimethlamino)propyl]carbodiimide as a condensing agent at room temperature followed by purification from low-molecular reagents. Method involves a single step that simplifies technology in preparing modified glycosaminoglycans.

EFFECT: improved preparing method.

3 ex

FIELD: biotechnology.

SUBSTANCE: invention relates to inhibitor of matrix metalloproteinases representing extract from fungus Canoderma atrum obtained by using of water and/or lower alcohols as extractant. Also disclosed are pharmaceutical agent for inhibition of tumor metastasis containing of 0.03-10 wt.% of abovementioned extract and foodstuff containing claimed extract.

EFFECT: improved inhibitor of matrix proteinases.

3 cl, 18 ex, 4 tbl

FIELD: pharmacy.

SUBSTANCE: invention proposes a medicinal agent for oral administration possessing an anti-inflammatory effect. Medicinal agent is made as a solid dosed formulation for oral administration that comprises meloxicam as an active substance, stearic acid or stearate as a slipping substance, maltodextrin as a binding agent, croscarmellose sodium salt as a disintegrating agent and dextrin as a filling agent taken in the definite ratio of components. Invention provides enhancing the biological availability of agent and improving its consumption properties. Invention can be used in the development of a medicinal agent made as a solid dosed formulation for oral administration possessing an anti-inflammatory effect.

EFFECT: improved and valuable pharmaceutical properties of agent.

10 cl, 11 tbl, 32 ex

FIELD: pharmaceutical industry, in particular anesthetic and vasodilating ointment.

SUBSTANCE: claimed ointment is prepared on the base of fine dispersed formulation contains apitoxin extract melittin, camphor, lavender, rosemary and eucalyptus oils and revitalin in specific component ratio. Ointment of present invention is useful in treatment of reumathysm, muscle and joint diseases, myodynia, radiculitis, ischias, neurodynia, polyneuritis, etc.

EFFECT: ointment with reduced apiotoxin toxicity, decreased side effects and improved therapeutic effect.

2 tbl

FIELD: pharmaceutical industry, in particular production of ointment having antiinflammation and antimicrobial activity.

SUBSTANCE: method for ointment production includes extraction of ground dogwood stones with chloroform during certain time followed by solvent removing and isolation of lipophilic fraction. Then dried solvent cake from dogwood stones is extracted with boiled purified water, solvent is removed and hydrophilic fraction is isolated. Further emulsifier, petrolatum and lipophilic fraction taken in specific ratio are fused at certain temperature; mixture is cooled and blended with water purified and heated up to certain temperature; obtained mixture is blended with solution comprising purified hydrophilic fraction, glycerol and water taken in specific ratio.

EFFECT: ointment of increased antiinflammation and antimicrobial activity.

2 tbl, 6 ex

FIELD: pharmaceutical industry, in particular production of ointment having antiinflammation and antimicrobial activity.

SUBSTANCE: method for ointment production includes grinding of plant raw materials namely solid coconut husk up to certain particle size; extraction with chloroform during certain time followed by solvent removing and isolation of lipophilic fraction. Further emulsifier, lipophilic fraction and coconut oil are fused under specific conditions; mixture is cooled to certain temperature and blended with celandine juice heated up to certain temperature.

EFFECT: ointment of increased antiinflammation and antimicrobial activity.

3 tbl, 15 ex

FIELD: veterinary.

SUBSTANCE: claimed ointment contains (mass %): fir oil 5.0-10; xeroform 3.0-6.0; and balance: ointment base.

EFFECT: nontoxic and hypoallergic ointment of with high effectiveness and prolonged storage time.

7 ex

FIELD: pharmaceutical industry, in particular anesthetic and vasodilating ointment.

SUBSTANCE: claimed ointment is prepared on the base of fine dispersed formulation contains apitoxin extract melittin, camphor, lavender, rosemary and eucalyptus oils and revitalin in specific component ratio. Ointment of present invention is useful in treatment of reumathysm, muscle and joint diseases, myodynia, radiculitis, ischias, neurodynia, polyneuritis, etc.

EFFECT: ointment with reduced apiotoxin toxicity, decreased side effects and improved therapeutic effect.

2 tbl

FIELD: pharmaceutical industry, in particular pharmaceutical preparation in ointment form for treatment of foul wounds.

SUBSTANCE: claimed agent contains as active ingredient combination of antibacterial agent dioxidine; methyluracil as agent accelerating cell regeneration; lidoxaine hydrochloride as topical anesthetic agent and polyethylene oxide 400 and 1500 as carrier in ratio of 1:4:2:(3.5-3.6):1, respectively. Claimed agent may be used in the first step of wound process.

EFFECT: agent having minimal collateral effect due to application of low toxic components.

3 tbl, 1 ex

FIELD: pharmaceutical industry, in particular production of ointment having antiinflammation and antimicrobial activity.

SUBSTANCE: method for ointment production includes extraction of ground dogwood stones with chloroform during certain time followed by solvent removing and isolation of lipophilic fraction. Then dried solvent cake from dogwood stones is extracted with boiled purified water, solvent is removed and hydrophilic fraction is isolated. Further emulsifier, petrolatum and lipophilic fraction taken in specific ratio are fused at certain temperature; mixture is cooled and blended with water purified and heated up to certain temperature; obtained mixture is blended with solution comprising purified hydrophilic fraction, glycerol and water taken in specific ratio.

EFFECT: ointment of increased antiinflammation and antimicrobial activity.

2 tbl, 6 ex

FIELD: pharmaceutical industry, in particular production of ointment having antiinflammation and antimicrobial activity.

SUBSTANCE: method for ointment production includes grinding of plant raw materials namely solid coconut husk up to certain particle size; extraction with chloroform during certain time followed by solvent removing and isolation of lipophilic fraction. Further emulsifier, lipophilic fraction and coconut oil are fused under specific conditions; mixture is cooled to certain temperature and blended with celandine juice heated up to certain temperature.

EFFECT: ointment of increased antiinflammation and antimicrobial activity.

3 tbl, 15 ex

FIELD: medicine.

SUBSTANCE: invention relates to pharmaceutical composition preferably in ointment form for treatment of skin lesions containing as active ingredient dexpanthenol and target additives such as fatty additives, namely solid, soft and liquid additives, emulsifier and water. As emulsifier cetostearyl alcohol is used. Composition of present invention has storage time not less than 2 years.

EFFECT: composition of improved quality and prolonged storage time.

8 cl, 2 tbl, 6 ex

FIELD: chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a method for preparing ophthalmic hydrocortisone ointment. Method involves mixing hydrocortisone acetate and a base prepared by melting Vaseline of sort "for ophthalmic ointments" and anhydrous lanolin at temperature 60-80°C at stirring, filtration through caprone fabric on funnel for hot filtration into thermostable capacity, sterilization in drying chamber at temperature 180-200°C for 1.5-2 h or in hermetic reactor by steam under pressure at temperature 120°C for 40-60 min, and preserving agents are added to the sterile melt at stirring. Ophthalmic ointment prepared by such method shows the improved adhesion properties and doesn't irritate the eye mucosa.

EFFECT: improved preparing method.

3 ex

FIELD: medicine, veterinary science, pharmacy.

SUBSTANCE: invention relates to an agent used in treatment of dermatomycosis. Agent comprises 2-mercaptobenzothiazole, glycerol and dimethylsulfoxide. Invention provides enhancing effectiveness in treatment of patients with trichophytosis and microsporia disease. Proposed agent is harmless, useful in using, allows reducing treatment period and decreases the labor intensity in its using.

EFFECT: improved and valuable properties of agent.

4 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to ointment used in treatment of scars by external using on a patient body. Ointment for treatment of scars comprises wax, vegetable oil, heparin, lydaze, glycerol and dimethylsulfoxide in the following ratio of components per 100 g: wax, 13-15 g; heparin, 5000-10000 U; lydaze, 64-128 U; dimethylsulfoxide, 10-15 ml; glycerol, 10-15 ml, and vegetable oil, the balance. Invention provides enhancing effectiveness in treatment of patients and the absence of adverse complications.

EFFECT: improved, enhanced and valuable medicinal properties of ointment.

1 tbl, 3 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to inflammatory agents. Invention proposes the ointment that comprises liquid potassium humate, birch tar, sodium silicate, vaseline wherein the potassium liquid humate comprises the humic substances in the amount 4.5 g/l, not less. Invention provides enhancing storage time, stability, high effectiveness and the broad spectrum of effect.

EFFECT: valuable medicinal and pharmaceutical properties of ointment.

2 cl, 6 ex

FIELD: cosmetic, in particular agents for skin care with abirritate effect.

SUBSTANCE: claimed cream contains cosmetic base, ephthyderm, malavit, additionally it contains precipitated sulfur, motherwort tincture, hawthorn extract, juniper oil, and jojoba oil, delargine, tocopherol acetate (Vitamin E), and retinal acetate (Vitamin A). All components are used in specific ratio.

EFFECT: cream with care with abirritate effect, for prophylaxis of allergic disorders, enhancement of skin tissue tension, reducing of xeroderma, and skin desquamation.

1 tbl

Up!