Cream for sensitive skin

FIELD: cosmetic, in particular agents for skin care with abirritate effect.

SUBSTANCE: claimed cream contains cosmetic base, ephthyderm, malavit, additionally it contains precipitated sulfur, motherwort tincture, hawthorn extract, juniper oil, and jojoba oil, delargine, tocopherol acetate (Vitamin E), and retinal acetate (Vitamin A). All components are used in specific ratio.

EFFECT: cream with care with abirritate effect, for prophylaxis of allergic disorders, enhancement of skin tissue tension, reducing of xeroderma, and skin desquamation.

1 tbl

 

The invention relates to cosmetics, namely the means for skin care, and primarily aimed at preventing the onset and exacerbation of allergic diseases accompanied by flaking and itching of the skin, with a calming effect.

Known cosmetic products for skin, which contain the active agent and various additives. So, cream for body skin by RF patent No. 2146515 A 61 K 7/48, 2000 contains an active ingredient of a number of derivatives ethylidenediphosphonic acid, and as additives, mineral oil, vegetable oil, wax emulsion, monoglycerides and/or glycerol monostearate, stearin cosmetics, lanolin anhydrous, triethanolamine, the acid is a weak organic, vitamins, preservative, flavoring and water. However, this skin cream has no concomitant medical-preventive, anti-allergic and calming effect.

Closest to the patent is a cream for the skin and body of the person who has the name "Malavtilin" (Patent RF №2189808 registered 27.09.2002 - prototype). Specified cream is manufactured by LLC "Medical diagnostic company "MEDIC", Ekaterinburg (License registration number PCV. Certificate of conformity №POCC.RU. PCA No. 3620511 from 21.10.1999,).

Specified as the prototype of the cream, including the basis attili is (contains epiderm - 40,0; petrolatum 40,0; lanolin - 5,0; ethanol 95% - 5,0; aminophylline 0,5; water - 9,5), extract of Siberian ginseng, Malawi, diphenhydramine, diclofenac, castor oil, glycerine, flavouring, proteolytic enzyme-filipin. The cream has anti-inflammatory, antiseptic and analgesic properties; prevents skin aging, reduces wrinkles, heals minor injuries. However, afterline included: alcohol, irritant action; lanolin and petrolatum, often causing allergic reactions and skin irritation (vaselina). The cream is not intended for sensitive skin and does not possess anti-allergic and calming effect.

The technical challenge is to improve the quality of the cream by excluding from its composition of ethyl alcohol, vaseline and lanolin and getting cream for sensitive skin, has soothing and anti-allergic effect by introducing into the cream ingredients that due to percutaneous activity epiderma quickly penetrate all layers of the skin, prolonging and intensifying their effect several times. (Cream instead of Foundation afterin used cosmetic Foundation with epidermal).

The technical result is achieved by the fact that the cream for sensitive skin, including Malawi, castor oil and a basis containing epiderm, water and e is fillin, characterized in that it further comprises a cosmetic basis, precipitated sulfur, tincture of motherwort, hawthorn extract, juniper oil, jojoba oil, tocopherol acetate (vitamin E), retinol acetate (vitamin a) and dalargin, in the following ratio, wt.%:

sulfur precipitated0,20-2,20
Malawi0,10-1,00
tincture of motherwort0,10-0,50
hawthorn extract liquid0,05-0,25
juniper oil0,05-0,30
jojoba oil0,05-0,30
tocopherol acetate (vitamin E)0,01-0,15
retinol acetate (vitamin a)0,01-0,15
dalargin0,01-0,15
cosmetic Foundationrest

Sulfur precipitated has anti-inflammatory and antiseptic effect, enhances the reparative ability of the skin. When the content of sulfur precipitated less than 0.20% of its effect is negligible, and when the content is more 2,20% appears keratolytic action.

Malawi has anti-inflammatory, antiseptic and analgesic action. When the content below 0.10% - the effect is negligible, and if maintained and more of 1.00% is dominated by the analgesic properties and reduces anti-allergic effects of the cream.

Tincture of motherwort is an adaptogen, it has a sedative effect, normalizes the blood flow to the peripheral parts, including the skin. When the content below 0.10% - the effect is negligible, and when the content of more than 0.50% is dominated by cardiovascular effect: lowers blood pressure, slows heart rate, greatly enhanced sedative effect, which reduces the effectiveness of the cream.

Hawthorn extract liquid - adaptogen, restores electrolytes and normalizes the components of the coagulation and Universiada blood systems, strengthens blood vessels of heart and brain, normalizes cholesterol metabolism, has a calming effect, normalizes sleep. When the content of the extract of hawthorn liquid less than 0.05% its effect is insignificant, and when the content of 0.25% of prevalent cardiovascular effect: increases myocardial contractility, slows heart rate; expressed anti-arrhythmic and anti-sclerotic effect. Juniper oil is an adaptogen, flavouring, antioxidant, anti-inflammatory and antiseptic effect. When the content is less than 0.05% its effect is insignificant, and when the contents exceed 0.30% of the desired effect is not increased, but increases sharply smell.

Jojoba oil is an adaptogen, anti-inflammatory, hydrating, softening and feeder is the first action, improves the consistency of cream. When the content in the cream jojoba less than 0.05% its effect is insignificant, and when the contents exceed 0.30%, the effect is almost not increased (the difference between false).

Tocopherol acetate (vitamin E) is an adaptogen, has capillariasis action, participates in the enzymatic chains of cells and biological membranes, normalizes metabolic processes.

When the cream is less than 0.01% vitamin E desired effect is insignificant, and when the content of more than 0.15%, the effect does not increase (the difference between false).

Retinol acetate (vitamin a) - adaptogen, affects the function of the epithelial structures, increases the number of mitoses in the epithelial cells and prevents the accumulation of keratohyaline, stimulates epithelization and prevent excessive keratinization of the epithelium (hyperkeratosis), prevents skin dryness. Contribute to the synthesis of RNA and sulfated mucopolysaccharides, which play a significant role in the permeability of cellular and subcellular membranes.

When its content in the cream less than 0.01%, the effect is sharply reduced when the content is more than 0.15% enhanced effect on hormonal metabolism and the desired effect is not increased (the difference between false).

Dalargin - immunomodulator, increases body resistance, decreases possibly the th of allergic reactions.

When the content in the cream of dalargin less than 0.001%, the effect is negligible, and when the content is more 0,0015%, the effect is almost not increased (the difference between false).

Cosmetic Foundation contains: 20% epiderma, at this concentration is most pronounced properties that determine its effect.

Epiderm - percutaneous conductor of biologically active substances, easily transports them to the fabric. He is a non-steroidal anti-inflammatory agent, anti-oxidant and anti-inflammatory effect, improves cell viability, the effect on the enzymatic system of biological membranes, which leads to the enhancement and prolongation cosmetic and therapeutic effect of all components of the composition. There is a decrease production of prostaglandins, histamine, bradykinin, the number of allergic and toxic complications; the local immunity; the metabolism of the skin.

Vegetable and castor oil - an oil phase of cosmetic foundations. Cetylstearyl alcohol is a viscosity modifier. Rosalyn - simulator. Aminol - emulsifier. Cabral - preservative. Aminophylline has vasodilator and anti-inflammatory effect.

Thus, fast-epidermal all components of the proposed structure in the tissue prolongs the effect of the cream to 20-22 hours is in, contributes to the normalization of metabolic processes and improves blood flow to all the structures of the skin, helps reduce the incidence of allergic nature, accompanied by dryness, flaking and itching of the skin, enhances the calming effect.

For the manufacture patentable cream for sensitive skin use the following ingredients:

- sulphur, precipitated by the global Fund X St,

- Malawi - according to THE 9158.001.29731500-95 and SanPiN 2.3.2.560-96,

- tincture of motherwort in GF XI St,

- hawthorn extract liquid by the global Fund X, St,

juniper oil - according to the current NTD,

- jojoba oil - according to the current NTD,

- tocopherol acetate (vitamin E) GF X St,

- retinol acetate (vitamin a) GF X St,

- dalargin - according to the current NTD,

- cosmetic emulsion base according to GOST 29189-91.

To get the cream in a pot stirrer load 75% of the required number of cosmetic emulsion base.

Each part of the cream dry ingredient is weighed on an analytical balance in the right quantity, is ground into fine powder, sieved through sieve No. 36, then carefully rubbed with a cosmetic emulsion basis in the ratio of at least 1:10 and fed into the boiler, followed by stirring for 5-7 minutes (each ingredient separately).

In the resulting mass of pooch the facility with constant stirring add the liquid ingredients in the right quantity, add up the required number basis and thoroughly stirred for 25-40 minutes to form a homogeneous mass of white or white with a yellowish or greenish color and odor, the respective ingredients used.

For comparative clinical trials used a composition of the following structures:

The cream for sensitive skin in clinical trials
№№p/pComponentsThe composition, wt.%
1234 Malathion
1Sulfur precipitated0,50-
2Malawi0,250,101,005,00
3Tincture of motherwort0,25-
4Hawthorn extract0,050,030,25-
5Juniper oil0,100,20
6Jojoba oil0,10-
7Tocopherol acetate. E0,04-
8Retinol acetate. And0,03-
9Dalargin0,010,050,15-
10Components of MalavtilinNo0,50
11Cosmetic Foundation with epidermal98,679598,84997,728594,3

Note. 1. Preliminary experimental studies were performed on animals, which is based on what is listed in the table of the composition do not have acute and chronic toxicity, local irritant effect, not cumulate, are potential allergens.

2. In the preliminary studies have determined the optimal concentration of epiderma, precipitated sulfur, tincture of motherwort, juniper oil, jojoba oil, tocopherol acetate (vitamin E) and retinol acetate (vitamin a).

3. Studied composition 1, 2, 3 with different concentrations of malavita, hawthorn extract liquid and glargine in comparison with the prototype - cream "Malavtilin" (track 4), which are listed in the table.

Compare the preliminary clinical study was conducted on 40 female volunteers aged 18-60 years, randomizirovannye into 4 groups equally. All women suffered from allergic: perioral dermatitis without exacerbation - 8 cases, neurodermatitis without exacerbation - 24,-papular plaque psoriasis, regressing stage - 8 cases. All women were dominated by dry skin with a single excoriation and peeling in the area of the lesions. Most of them noted itching (87,5%), insomnia (65%), irritability (72,5%).

Women put the appropriate group face cream and skin areas 2 times a day within 30 days.

Check parameters was carried out before the use of the cream at 3, 7, 14, 21 and 30 days of its application. In the process of study is determined by hydrogen ion exponent (pH) of the skin, which before the test was significantly increased in all women. Visually evaluated skin type, its turgor, wrinkles, rashes, etc., studied the subjective state of the women on map of SAN (health, activity, mood). All studies were performed according to standard techniques. It was recommended not to use irritating cosmetics.

In the research it was found that all creams had no negative effects.

All women group 1 2-3 days of applying the cream disappeared itching; 3-4 day no skin peeling and excoriation; 10-11 day decreased cohost the skin and wrinkles on the face; normalized sleep; increased skin turgor; there was a decrease in pH to 5.30-6,40, and by 30 days of its normalization.

Women 2 and 3 groups, these changes occurred in 3-6 days later, in group 4, on a 7-9 day use of Malavtilin itching disappeared, for 3-4 day excoriation; 14-15 day moderately decreased wrinkles, dryness and skin peeling. However, there is no normalization of the pH of the skin and sleep. In the analysis of the subjective state test SAN women, especially in group 1, noted improvement in health, sleep, increasing daily activity. Improved mood, lost the feeling of depression. In addition, group 1 noted the disappearance of dry, peeling skin and the fact that they have become more attractive.

So, patent-pending cream (composition I), optionally containing cosmetic Foundation with epidermal, precipitated sulfur, tincture of motherwort, hawthorn extract, juniper oil, jojoba oil, tocopherol acetate (vitamin E), retinol acetate (vitamin a) and dalargin, more efficient prototype optimizes pH, reduces wrinkles, improves skin, eliminates dryness and peeling, normalizes sleep improves the quality of the cream has a soothing and anti-allergic action.

Thus, topical application of the composition 1 with itching, flaking and dryness of the skin from excoriation, accompanied by sleep disturbance, when allerg the medicine provided a good effect, advancing through 2-11 days of applying the cream. He was manifested in the rapid disappearance of itching, breakage and peeling of the skin, eliminating dryness significant reduction in the number and depth of wrinkles, normalize pH. All women significantly increased daily activity, improved night's sleep. All women reported better mood, lost the feeling of depression.

This cream was given the name "Cream for sensitive skin".

Thus, patenting serves cream for sensitive skin, combining cosmetic and medicinal properties, based on the use of non-deficient ingredients natural and organic origin.

Literature.

1. Topical issues of Allergology and immunology. Tashkent, s-83.

2. State Pharmacopoeia of the USSR. M.: Medicine, X, XI edition.

3. Guidelines for the assessment of the allergenic properties of pharmacological agents. M.: Medicine, 1988, p.19.

4. Hand A., Tauber R. disorders of hair and scalp. M.: Medicine, 1985, 528 S.

5. Manual immunopharmacology. / Ed. Dale M.M., Formen JK M: Medicine, 1998, 332 S.

6. Skripkin J.K. Skin and venereal disease. M.: Medicine, 1979, p.18-410.

7. Requirements for pre-clinical study of the General toxic action of new pharmacological substances. M., 1985, p.18.

8. Turov, A. D., E. Sapozhnikova. karstenia plants of the USSR and their use. M.: Medicine, 1982, 288 S.

9. Urbach VY Statistical analysis in biological and medical research. M.: Medicine, 1975, 290 S.

Cream for sensitive skin on the basis of epiderma, oils and additives, including Malawi, characterized in that it further comprises a cosmetic basis, precipitated sulfur, tincture of motherwort, hawthorn extract, as the oils used juniper oil and jojoba oil, and as additives for use dalargin, tocopherol acetate (vitamin E) and retinol acetate (vitamin a) in the following ratio, wt.%:

Epiderma 10,00 25,00
Sulfur precipitated0,20-2,20
Malawi0,10-1,00
Tincture of motherwort0,10-0,50
Hawthorn extract0,05-0,25
Juniper oil0,05-0,30
Jojoba oil0,05-0,30
Dalargin0,01-0,15
Tocopherol acetate (vitamin E)0,01-0,15
Retinol acetate (vitamin a)0,01-0,15
Cosmetic FoundationRest



 

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