Method for correcting erectile dysfunction
SUBSTANCE: method involves carrying out vacuum massage of prostate with an apparatus. Tampons with 40-45°C hot sulfide mud taken from Sucsun pond are additionally rectally introduced for 20-30 min. The total treatment course is 8-10 procedures long. Daily microenemas are prescribed with mineral water at 36°C in a 10 procedures long course.
EFFECT: enhanced effectiveness of treatment.
The invention relates to medicine, namely to urology - andrology, and can be used to correct erectile dysfunction in chronic prostatitis, post infectious diseases, injuries and other
A known method for correcting erectile dysfunction vacuum massage machine potowatomi therapy ANGL-01 - "YAROVIT" (Manufacturer research Institute "Polyus", Moscow).
The disadvantages of this method: insufficient anti-inflammatory and anti-edematous effect weak effect on the production of sex hormones.
The invention is aimed at solving problems: improvement of results of treatment, removal of inflammation.
Technical result: pain, strengthening erections, improve spermatogenesis.
These objectives are achieved by assigning the patient along with vacuum massage of the prostate apparatus "YAROVIT" microenema with mineral water "Keys" and sulphide silt mud Suksun pond in the form of rectal swabs.
The method is as follows:
The patient microclysters with mineral water in the Keys. According to GOST 13273-88 "mineral drinking Water treatment and treatment-drinking" the water "Keys" refers to the 12 group sulphate magnesium-calcium waters of Smolensk type, has a salinity of 2.45 mg/dmcvb., the pH was 7.3, with a shift in the alkaline side, which provides anti-inflammatory effect. Microclysters released daily water temperature 36°S, exposure time 60 minutes, a course of 10 treatments.
Simultaneously use the sulphide silt mud Suksun pond in the form of rectal swabs with mud temperature 40-45°s With a duration of 20-30 minutes daily course of 8-10 treatments. Mud Suksun pond refers to mineralized silt sulfide mud lake-key type and meets all the requirements of GOST requirements for this type of mud. Dirt is a peloid soft consistency of the black or black and gray. Physico-chemical properties of the mud: specific gravity of 1.65-1.70 g/cm3. Shear 1600-1800 Dyne/cm2the heat capacity of 0.62 cal; contamination particles >0.25 mm to 0.19-1.70 percent; the redox potential varies between 200-220 mW. The ionic composition of the mud solution hydrocarbonate-calcium fortified foods. Total mineralization 1,8520 g/l, pH of 7.8. Solids are clay skeleton silicate composition (up 31%) and carbonates of calcium and magnesium (up 9%). The content of organic substances in the peloid - 3,56% dry matter. 100 g wet mud contains up to 100 mg HS and up to 250 mg FeS.
The main therapeutic effects of silt sulfide peloids: protivovesa the tion, immunomodulatory, desensitizing, biostimulating, metabolic and reparative-regenerative, defibrotide, keratolytic, antibacterial. The main factors peloid - thermal, mechanical and chemical: irritating thermo-, mechano-, Baro-, chemo - and osmoreceptor skin and providing a complex reflex and humoral effect on the body of the patient.
In addition, the use of LOD-therapy - the impact of local negative pressure using the apparatus for vacuum massage AMBLE - 01 - YAROVIT. When conducting valdecabras creating favorable conditions to restore the function of the circulatory channel of the penis at all levels of the system (arteries, veins, capillary network), restored trophic all tissues of the penis, increases the total volume of the corpora cavernosa, the tissue saturated with oxygen, the mechanisms of emotional arousal, revive the weakened nervous communication. The reflex influence of LOD-therapy on the prostate causes the activation of blood circulation, improve metabolism, androgenresponsive function and trophic gland, stimulates neurohumoral activation of spinal and cortical-subcortical centers, helps to increase blood flow into the cavernous tissue of the cavernous those who. Treatment 8-10 procedures, the exposure time is 10 minutes
Examples of specific performance.
Patient P. 57 years old, married, has children. Participant of liquidation of the accident at the Chernobyl nuclear power plant.
Complaints: weak flow of urine, a significant reduction of erections, erections, sluggish, spontaneous, persistent self-doubt. Suffering for 3 years, not surveyed, treatment was not carried out. Examination: external genitals correctly formed, the testicles in the scrotum, epididymis without features. Rectal: prostate slightly swollen, fuzzy contours, testovaty, painless, Magdalena furrow smooth. Ultrasound: the prostate gland the size of 4.2 and 3.4-2.6 cm, heterogeneous structure, no residual urine. The diagnosis of chronic prostatitis. Of erectile dysfunction.
Treatment: vacuum massage of the prostate using the apparatus of YAROVIT for 10 minutes daily No. 8, rectal swabs with silt sulfide mud Suksun pond with a temperature of 40-45°With 30 minutes daily, 10 and micro mineral water in the Keys at a temperature of 36°With 60 minutes daily No. 10.
2-3 days of treatment the patient reported improvement of urination, appeared spontaneous elastic erection. After the 5th day was full sexual intercourse.
Patient X. 64 years old, and married with children. Complaints: weak flow of urine, incomplete, about the Yan rare, spontaneous erection. Examination: external genitals correctly formed, the testicles in the scrotum, epididymis without features. Rectal: prostate is slightly enlarged, the tone is satisfactory, painless, Magdalena furrow saved. Ultrasound: the prostate gland the size of a 4.8 a 4.3-3.1 cm, heterogeneous structure, no residual urine. The diagnosis of BPH 1 tbsp. of Vasculogenic erectile dysfunction, blood type.
Treatment: vacuum massage of the prostate using the apparatus of YAROVIT for 10 minutes daily No. 10, rectal swabs with silt sulfide mud Suksun pond with a temperature of 40-45 for 20 minutes a day # 10 and micro mineral water in the Keys at a temperature of 36°With 60 minutes daily No. 10.
The treatment appeared spontaneous erections, improved urination.
Patient M., aged 40, is married and has children. Two years ago, there was trauma to the scrotum: a large hematoma, operative treatment. After discharge from the hospital more than a month to refrain from sexual intimacy, then - rare sex because of the "expectation failure", decreased libido, spontaneous erections saved. Examination: external genitals correctly formed, the testicles in the scrotum, epididymis without features. Rectal: the prostate gland is not enlarged, reduced tone, Bisbal is being emitted by contaminated, Magdalena furrow is not expressed. Ultrasound revealed no pathology. Diagnosis: post-traumatic psychogenic erectile dysfunction.
Treatment: vacuum massage of the prostate using the apparatus of YAROVIT for 10 minutes daily No. 8, rectal swabs with silt sulfide mud Suksun pond with a temperature of 40-45 for 20 minutes a day # 10 and micro mineral water in the Keys at a temperature of 36°With 60 minutes daily No. 10.
After 3-4 days of treatment the overall mood has improved, there libido, sexual contact with a strong orgasm. After completing the full course of treatment the patient had no complaints.
Patient B., age 37, married with children. In 2003, the fracture of the pelvic bones, rupture of the urethra, surgical treatment, in which the urine has been restored. Erection is virtually absent, no spontaneous erections, libido saved. Was treated conservatively by place of residence. Examination: external genitals correctly formed, the testicles in the scrotum, epididymis without features. The penis is slightly deformed by scars. Rectal: the prostate gland is not changed. Diagnosis: posttraumatic erectile dysfunction, mixed form.
Treatment: vacuum massage of the prostate using the apparatus of YAROVIT for 10 minutes daily No. 10, rectal shall amphony with silt sulfide mud Suksun pond with a temperature of 40-45° With 30 minutes a day # 10 and micro mineral water in the Keys at a temperature of 36°With 60 minutes daily No. 10.
After the 6th day of treatment achieved complete swelling of the penis, developed spontaneous erections, and moderate swelling member when viewing erotic films. The Masturbation episode ended with ejaculation and orgasm.
This comprehensive method of treatment using natural mineral factors contributes to the improvement of results of treatment, the pain and the inflammatory process leads to increasing erection and improving spermatogenesis.
Treatment of erectile dysfunction using hardware vacuum massage prostate cancer, wherein the patient is additionally prescribed rectal swabs sulphide silt mud Suksun pond with a temperature of 40-45°s With a duration of 20-30 minutes, the course of 8-10 treatments, and micro mineral water "Keys" with a temperature of 36°With daily treatment 10 treatments.
FIELD: medicine; medical engineering.
SUBSTANCE: method involves exposing cavernous bodies of compulsory erected penis and urogenital system tissues to physical factor complex action as pulsating pressure-mediated local negative pressure therapy and low intensity red bandwidth laser radiation. Noninvasive penis treatment with contrasting temperatures and vaso-active exogenous substances like ozone/NO-air gas mixture are additionally applied. The device has transparent penis flask having throttling orifice, cover-holder, light-emitting diode matrix, vacuum pump for creating negative pressure pulses in the penis flask, laser radiation sources, magnetic and electric field sources and rectal heater. The device has source of exogenous vaso-active substance like ozone/NO-air gas mixture and source for heating the atmospheric air. On-off valve having control solenoid coupled to deactivator of waste exogenous vaso-active substance like ozone/NO-air gas mixture is mounted in the throttling orifice of the penis flask. The penis flask is connected to movable upright via carrier holder and hinged articulation system having movable upright allowing varying penis flask orientation with height and spread angle relative to the penis.
EFFECT: enhanced effectiveness of anti-inflammatory treatment; improved erection stimulation mechanisms.
2 cl, 8 dwg, 1 tbl
FIELD: organic chemistry, medicine, biochemistry.
SUBSTANCE: invention relates to new compounds of the formula (I) wherein R1 and R2 can be similar or different and represent independently (C1-C6)-alkyl that are selective inhibitors of enzyme phosphodiesterase, and to their pharmaceutically acceptable salts or stereoisomers. Also, invention involves a method for preparing the preferable compound, i. e. 5-[[2-ethoxy-5-(cis-2,6-dimethylpiperazin-4-ylsulfonyl)phenyl]]-1-methyl-3-n-propyl-7,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine-7-one. Also, invention proposes new intermediate compounds used in method for synthesis of this compound. Compounds of the formula (I) show very high effectiveness in treatment of diseases associated with impotence, such as the male erectile sterility but they exhibit such features as prolonged therapeutic effectiveness and lower toxicity. Also, invention relates to a pharmaceutical composition used in treatment of impotence and using compound of the formula (I) in preparing the medicinal preparation designated for treatment of diseases associated with impotence.
EFFECT: valuable medicinal properties of compound.
8 cl, 7 ex
FIELD: organic chemistry, biochemistry, pharmacy.
SUBSTANCE: invention relates to 5-aminoalkylpyrazolo[4,3-d]pyrimidines of the general formula (I): wherein R1 and R2 are similar or different and represent independently of one another (C1-C8)-alkyl group; R3 and R4 are similar or different and represent independently of one another (C1-C8)-alkoxy-group or halogen atom; R5 and R6 can be similar or different and represent independently of one another hydrogen atom, linear or branched (C1-C8)-alkyl group that can be substituted with one or more hydroxyl groups, (C1-C8)-alkoxy-, amino-, mono-(C1-C8)-alkyl-amino-, di-[(C1-C8)-alkyl]-amino-, N-morpholino- or pyridyl groups or in common with nitrogen atom to which they are bound form unsaturated heterocyclic ring that comprises optionally one or more additional atoms of nitrogen and/or oxygen and substituted with one or more hydroxyl, (C1-C8)-alkylol, (C1-C6)-oligohydroxyalkyl, amino-, mono-[(C1-C8)-alkyl]-amino- or di-[(C1-C8)-alkyl]-amino-groups. Proposed compounds inhibit activity of cGMP-phosphodiesterase and can be used in treatment of states of cardiovascular system and for treatment in potency disturbances. Also, invention relates to a medicinal preparation used for inhibition of activity of cGMP-phosphodiesterase based on indicated compounds, a method for preparing compounds of the formula (I) and a method for preparing the medicinal preparation.
EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds and composition.
7 cl, 15 ex
FIELD: medicinal pharmacology.
SUBSTANCE: the present innovation deals with minor peptides which could be characterized with the following formula: X-A-B-C-Y-NH2, where X - α-aminoisobutiryl, tranexamyl (i.e.4-(aminomethyl)cyclo-hexane carbonyl), isonipecotinyl, γ-aminobutiryl, hydrogen or imidazolylacetyl, A - D-2-methyltryptophan, D-β-(2-naphthyl)alanine or D-tryptophan, B - D-2-methyltryptophan, D-β-(2-naphthyl)alanine, D-tryptophan or is absent, C - D-2-methyltryptophan, phenylalanine or is absent, Y - lysine or arginine, where D means dextroisomer, or pharmaceutically acceptable salt of peptide that induces penile erection. Also, pharmaceutical composition is suggested that contains these peptides, and methods for treating erectile dysfunctions.
EFFECT: higher efficiency.
12 cl, 7 ex
FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to new derivatives of pyrrolopyrimidine of the formula (1) and their pharmaceutically acceptable salts possessing properties of selective inhibitor of specific cyclic guanosine 3',5'-monophosphate phosphodiesterase (specific cGMP PDE) (PDE V). In the formula (1) R1 represents hydrogen atom (H), (C1-C3)-alkyl substituted optionally with one or some fluorine atoms; R2 represents H, halogen atom, (C1-C6)-alkyl substituted optionally with hydroxyl group (-OH), (C1-C3)-alkoxy-group, (C3-C6)-cycloalkyl or one or some fluorine atoms, (C3-C6)-cycloalkyl; R3 represents (C1-C6)-alkyl substituted optionally with (C3-C6)-cycloalkyl or one or some fluorine atoms; R4 represents (C1-C6)-alkyl substituted optionally with one or some fluorine atoms; R5 represents -SO2NR6R, -NHSO2R8 or heterocyclyl such as tetrazolyl; each R6 and R7 represents independently H or (C1-C6)-alkyl substituted optionally with -CO2H or one or some fluorine atoms; or in common with nitrogen atom to which they are bound form monocylic ring, such as imidazole, pyrrolidine, piperidine, morpholine, piperazine and homopiperazine wherein indicated group is replaced optionally with R9 wherein R9 represents (C1-C6)-alkyl substituted optionally with one or some halogen atoms, hydroxyl group (OH), (C1-C3)-alkoxy-group that is replaced optionally with one or some fluorine atoms, -NR11R12, -C=NR13(NR14R15) or tetrazolyl group, 6-membered nitrogen-containing heteroaryl group; each R11 and R12 represents independently H or (C1-C4)-alkyl; R13represents H; each R14 and R15 represents independently H. Also, invention relates to intermediate compounds, methods for preparing compounds and pharmaceutical compositions. Proposed compounds can be used in treatment of impotency, sexual dysfunction in females, stable, nonstable and variant (Prinzmental) stenocardia and other diseases also.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
15 cl, 1 tbl, 250 ex
FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to 2-aminomethylthieno[2,3-d]pyrimidines of the general formula (I): wherein R1 and R2 in common with C-atoms with which they are bound form 5-7-membered monounsubstituted cycloalkenyl ring; R3 and R4 are similar or different and represent independently of one another (C1-C8)-alkoxy-group or halogen atom; R5 and R6 can be similar or different and represent independently of one another hydrogen atom, linear or branched (C1-C8)-alkyl group that can be substituted with one or more hydroxyl, (C1-C8)-alkoxy-group, amine, mono-(C1-C8-alkyl)-amine or di-(C1-C8-alkyl)-amine groups, or in common with nitrogen atom to which they are bound form a heterocyclic ring that comprises optionally one or more additional nitrogen atoms and substituted with one or more hydroxyl, (C1-C8)-alkoxy- or (C1-C8)-alkylol groups. Compounds elicit the inhibitory effect with respect to activity of phosphodiesterase V and can be used in treatment of cardiovascular system states and in disturbance in the potency injury. Also, invention describes a medicinal preparation based on compounds said, a method for its preparing and a method for preparing compounds.
EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds.
6 cl, 1 tbl, 16 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to inflammatory agents. Invention proposes the ointment that comprises liquid potassium humate, birch tar, sodium silicate, vaseline wherein the potassium liquid humate comprises the humic substances in the amount 4.5 g/l, not less. Invention provides enhancing storage time, stability, high effectiveness and the broad spectrum of effect.
EFFECT: valuable medicinal and pharmaceutical properties of ointment.
2 cl, 6 ex
FIELD: pharmaceutical industry, in particular production of moor preparation.
SUBSTANCE: claimed method includes extraction of moor raw material such as peaty piloids with decomposition rate of 50 % or more, decontamination, homogenization by agitation in mortar-mixer with addition of mineral sodium hydrocarbonate water under specific conditions followed by pulping through screen to produce product with shearing resistance of 1500-4000 din/cm3 and conserving agent addition. As conserving agent hydantoin in specific ratio is used. Then product is pre-packed in sealed containers and conditioned in stock for ageing.
EFFECT: peaty moor dough with increased biological value, high penetrability, improved nutrient and healing effects.
FIELD: method for production of bioproducts from native divot peloid with high biological activity.
SUBSTANCE: claimed method includes extraction of fine dispersed divot peloid having plant residual decomposition ratio of 50 % or more with sodium hydrocarbonate-containing water at elevated temperature under intensive agitation to produce homogeneous suspension followed by separation under certain conditions.
EFFECT: ecologically pure concentrated peloid extract with high biological activity.
FIELD: medicine, phthisiology.
SUBSTANCE: in early period the preparation "Yantar-antitoks" is used in the dose 0.5 g, 3 times per a day for one month in addition to the conventional antituberculosis therapy. Invention promotes to elimination of symptoms associated with the total intoxication, resorption of focus-infiltration changes, elimination of destructions and ceasing secretion of microorganisms for shorter periods. Invention can be used in treatment of pulmonary tuberculosis.
EFFECT: improved method for treatment.
4 tbl, 1 ex
FIELD: medicine, gynecology.
SUBSTANCE: patients should be suggested to take radon procedures as baths, gynecolopgical irrigations, microenemas, laserotherapy in autoresonance mode at altering frequency of laser apparatus independently against frequency characteristics of human body, at wave length of 0.89 mcm, power of 10 W onto area of uterine projection in case of genital endometriosis and uterine myoma at exposure of 15 min and onto mammary glands in case of diffuse proliferative mastopathies. Impact fields should be chosen by sectors ranged 10-16 per 10-15 sec for each impact field. Local therapy should be conducted about 2.5-3 h after taking radon procedures successively, not earlier. The first stage - baths with malavit at 1:5 dilution at exposure of 15 min. The second stage - after removing the solution out of vagina it is necessary to introduce malavit gel at a tampon for 4-6 h. The whole therapy should be carried out together with internal intake of mineral water 30-60 min before meals thrice daily per 3.5 mg/kg body weight. The innovation enables to achieve prolonged remission, normalize hormonal level in blood and duration of the second phase of the cycle and decrease cholesterol level in blood.
EFFECT: higher efficiency of correction.
1 dwg, 4 ex