Method for treating oncologic patients

FIELD: medicine.

SUBSTANCE: method involves injecting membrane-associated antigen vaccine from destroyed tumor cells. Biopsy tumor cells taken from patient are used as raw vaccine material. Vaccine is produced by irradiating cell suspension with pulsating electric field having succession frequency and rectangular pulse duration equal to 35-50 Hz and 5-7 ms, respectively, specific current amplitude being equal to 300-500 mcA during 30-40 min in microelements presence. The injection is carried out by subcutaneously implanting incubator-carriers manufactured from porous titanium nickelide having vaccine deposited into the pores.

EFFECT: enhanced effectiveness of oncologic disease treatment.

3 cl

 

The invention relates to medicine.

theory of abnormal growths of body tissue (tumors) is an old and timeless problem of science, and cancer treatment - emergency medicine task. The diversity of forms of tumors and extremely heavy, to the social scale, the effects of the disease determine the breadth and depth of search methods. The greatest attention of researchers involved in malignant tumors.

Known and more used chemotherapy of cancer. Due to the source resistance of 50% of malignant tumors to the toxic effects of chemotherapy and acquisition of such resistance 49% of the tumors in the treatment process, the effectiveness of chemotherapy is very low.

Surgical methods of treatment of oncological diseases are shown and relatively effective for the treatment of non-or moderately advanced cases. However, surgery is an invasive procedure, which requires the observance of certain conditions General condition of the patient, typically attenuated developing the disease.

A promising alternative to these methods, partially eliminating their shortcomings, were known since the end of the last century biological methods of treatment of oncological diseases. At their core, they are immune stimulation is th system of the patient to fight tumor cells. A special case of this treatment is vaccination the patient specially developed vaccines - vaccine therapy of cancer. This direction in the last decade was characterized by the search for vaccines, any reducing mortality statistics or prolonging the life of the patient. However, even a small increase in the efficiency of new developments is considered to justify the costs and worthy of formal protection.

There is a method of treatment of cancer, including subcutaneous (needle) injection of a vaccine containing its basis in the destroyed cell tumors of mice [Seledtsov V. Report on the meeting of the Presidium of SB RAMS, Novosibirsk, Department of immunopathology GU NIKE SB RAMS, Russia, 21 may 2003]. By the greatest similarity of this analogue is selected as a prototype of the present invention. Inducing the course is 8-12 injections performed with an interval of 7-14 days for 4 months, and then, in the next 6 months intervals between injections are 14-30 days. In parallel, patients injected immune-stimulating Roncoleukin to enhance the effects of the vaccine.

The effectiveness of vaccine therapy in this way is evaluated on the basis of statistics 30% regression of tumors during the year. This result, of course, does not solve the problem satisfactorily. Thus, the disadvantage of this method is low efficiency is aktivnosti treatment.

The technical result of the invention is the improved treatment of cancer.

This technical result is achieved in that in the method of treating cancer, comprising an injection membrane-associated antigenic vaccine from the destroyed tumor cells, as the source material vaccines use a biopsy of the tumor cells of the patient, preparation of the vaccine include irradiation of cell suspensions electric field pulse current with a frequency and duration rectangular pulses respectively 35-50 Hz, 5-7 msec, the amplitude of the specific current 300-500 ICA in the presence of trace elements, the injection is carried out by implanting subcutaneously media incubators of porous titanium nickelide deposited in their pores vaccine.

Preferably this procedure repeatedly, with a frequency of 5.5-6.5 months. It is preferable to implant the media - incubators with the amount deposited vaccine 40-60 microlitres, content of 1.5-2.5 million destroyed tumor cells in each medium.

Achievable technical result due to a complex of measures to increase the activity of vaccines used. The complex consists of different, compared with the prototype, the source material (tumor cells of the patient, the irradiation of suspense the modal electric field and inhibition of cell trace elements (endogenous iontophoresis cells)). The mechanism and the sum of the effects from each of the named factor theoretically poorly justified and, in the main, determined experimentally, studies on laboratory animals. At least, found that the addition of non-additive and, therefore, not obvious ("inventive step").

The technical result is also supported by the new technique of injection of the vaccine to the patient. Porous media from a Nickel-titanium deposits vaccine, which gradually Razorbill the implant into the surrounding tissue of the body, evenly distributing at the time of its therapeutic action. The remaining amount is still unspent amount of the vaccine are protected from attack by killer cells. Thus, the porous nickeled-titanium media also plays a role incubator cells. Minimally invasive (transcutaneous) the implantation of carriers is done once in six months, unlike reusable glowcolor of injury to the patient by the method of the prototype.

The effectiveness of the vaccine was developed and tested experimentally on the basis of nursery research laboratory experimental simulation of the Tomsk scientific centre SB RAMS. Research performed at 650 inbred lines IAS, C57/BL/6J) adult mice with experimentally induced tumors carcinoma, Lewis lung adenocarcinoma Ehrlich melanoma b 16. Was shown the possibility to control the growth of tumor cells and metastatic activity.

Mode electric and ion treatment of the suspension is determined by the series of studies on the inhibition of cells in vitro [RU No. 2179578] using the Pacer digestive tract [Agafonnikov V.F., Dambai GC, Romanov M.N. Autonomous electrical stimulator of gastrointestinal tract. The monograph. Tomsk. 1999., p.26-27]. The exposure time can be determined experimentally by condition 100%inhibition of cells according to the test abrasivejet Trifanova blue. Exposure to more than 40 min has no practical sense. The selection of the necessary trace elements is determined by the type of tumor and produced by the well-known recommendations.

The obtained experimental data allowed us to use the proposed method in clinical practice and to confirm the reachability of a technical result.

Clinical example:

Patient E., 49, engineer production processing uranium, enrolled in a planned manner in the surgical clinic. Agiving Siberian state medical University 07.04.2000, disease Diagnosis: poorly differentiated adenocarcinoma of the pancreas stage IV with metastasis to liver, lungs, retroperitoneal space, ascites, insulinotropic diabetes.

Clinical doubledave is receiving the diagnosis was confirmed. The patient was supposed to perform pancreatoduodenal resection. However, during the operation detected tumor invasion into the aorta, portal vein, the root of the mesentery, and the process was declared inoperable. The operation was completed preventive imposition of cholecystojejunostomy and additional anastomosis brown.

Two weeks after surgery, patients received treatment of cancer of the proposed method.

Used vaccine, manufactured by known techniques [Biological methods of treatment of oncological diseases. Edited by Vincent T. De Vita. M.: Medicine, 2002. s] from the destroyed cells tumor biopsy material irradiated in vitro by an electric field pulse current in the presence of trace elements (zinc). As a technical tool used electronic stimulator (ES) tract, which was placed in a cell suspension at the time of 30 minutes electric mode ES tract: rectangular pulses of electric current with an amplitude of 10 mA, a pulse duration of 6 MS, a repetition rate of 40 Hz in batches of 16 pulses in each. Trace element deposited electrochemically on the electrode stimulator. Thus, during the duration of stimulant exposure of cells to electric field is produced synchronously with the endogenous iontophoresis, and the electric field force which induces the absorption of trace cells. Prepared cell vaccine sown on media incubator of porous titanium nickelide by soaking its volume suspension.

Media-incubators in the amount of 6 pieces implanted subcutaneously using a trocar into the abdomen. Additionally, to compensate for pancreatic insulinotropic diabetes implanted islets of the pancreas of pigs in porous media-incubator Nickel-titanium.

The postoperative period was uneventful, and the patient is in satisfactory condition was discharged under the supervision of a medical oncologist at the place of residence.

In December 2000, the patient was admitted to the hospital with symptoms of obstructive jaundice. Found a total defeat of the large duodenal papilla. Made choledochoenterostomy. Earlier imposed cholecystojejunostomy obliterator. After edema jaundice held the second session of treatment of oncological diseases. In June 2001, an examination showed reduction of tumor invasion into the abdominal cavity, reducing by 30% the size of the tumor. Made the third treatment session.

The patient continued to work in the specialty, every six months for medical examination and take the treatment. Stable picture of the disease and lack of progression was observed until August 2003, when due to the massive collapse of the whole in the duodenum happened bleeding, and the patient died.

More than three years to prolong life and maintain the ability to work sick regarded as a good result of the vaccine therapy.

The proposed method is used in the clinic to them. Agiving since 1999. Were treated cancer of different nosology in 30 patients with advanced IV stages of the neoplastic process, and passed other pre-treatments: surgery, courses of chemo-, hormone - and radiotherapy. All patients upon admission were performed on a biopsy of the tumor or metastasis. Part of the biopsy material was sent for histological examination, and the remaining was used to develop vaccines. After implantation media incubators for patients was established dynamic observation of clinical effect and careful monitoring of the immune status. The follow-up period for various reasons ranged from 3 months to 4 years. In the statistics of the observations set the remission process, the lack of progression of cachexia, normalization of peripheral blood, immune status and reduce tumor volume by 30% or more.

Evaluation of the clinical effect was detected prior to application of the proposed method with aftercare seriously ill after surgery.

The achieved result and t is nicheskaja the perfect way sufficient to match the criteria of the invention "industrial applicability".

1. A method of treating cancer, comprising an injection membrane-associated antigenic vaccine from the destroyed tumor cells, characterized in that as starting material vaccines use a biopsy of the tumor cells of the patient, preparation of the vaccine include irradiation of cell suspensions electric field pulse current with a frequency and duration rectangular pulses respectively 35-50 Hz, 5-7 MS, the amplitude of the specific current 300-500 µa for 30-40 min in the presence of trace elements, the injection is carried out by implanting subcutaneously media incubators of porous titanium nickelide deposited in their pores vaccine.

2. The method according to claim 1, characterized in that the treatment carried out repeatedly with a frequency of 5.5-6.5 months.

3. The method according to claim 1, characterized in that the implanted carriers-incubators with the amount deposited vaccine 40-60 μl, content of 1.5-2.5 million destroyed tumor cells in each medium.



 

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