Derivatives of benzamidoacetonitrile, method for their preparing, composition comprising thereof for nematode control and their using

FIELD: organic chemistry, nematocides.

SUBSTANCE: invention relates to compounds of the formula (I): wherein Ar1 and Ar2 mean independently of one another unsubstituted phenyl or mono- or multi-substituted phenyl with substitutes having independent of one another values and chosen from the group including halogen atom, (C1-C6)-alkyl or halo-(C1-C6)-alkyl; Q1 means -OCH2 or -C(O); Q2 means a direct bond or -C(O); R3 means hydrogen atom; R4, R5 and R6 mean independently of one another hydrogen atom or (C1-C6)-alkyl; W means O or S atom; a means 1, 2, 3 or 4; b means 0; n means 0 or 1. Also, method proposes a method for synthesis of compound of the formula (I) and carriers and/or dispersers also. Also, invention proposes using compound of the formula (I) for control of nematodes. Invention provides preparing derivatives of benzamidoacetonitrile used in control of nematodes.

EFFECT: improved preparing method, valuable properties of compounds.

10 cl, 2 tbl, 19 ex

 

The present invention relates to new benzenediacetonitrile compounds of the formula

in which Ar1and Ar2independently from each other represent unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenyl, halo,-C2-C6alkenyl, C2-C6quinil, C3-C6cycloalkyl, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonates, halo,-C1-C6alkylsulfonates, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino, di-C1-C6alkylamine the group, C1-C6alkylsulfonamides, halo,-C1-C6alkylsulfonamides, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted fenoxaprop either one or mnogozahodnoy fenoxaprop, substituents which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6al is ylsulphonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted phenylacetylene either one or mnogozalny phenylacetylene, substituents which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, and an unsubstituted pyridyloxy either one or mnogozahodnoy pyridyloxy, substituents which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted or indicate heteroaryl either one or mnogozalny heteroaryl, Zam is stitely which can be independent from each other values and selected from the group including halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C1-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino and di-C1-C6alkylamino, or represent unsubstituted naphthyl or chinolin either one or mnogozalny naphthyl or chenail, substituents which may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkyls final, halo-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino and di-C1-C6alkylamino,

Q1denotes CH2, OCH2, S, S(O), S(O2) or S(O)

Q2denotes a direct bond or C(O),

R3denotes hydrogen, C1-C6alkyl, halo,-C1-C6alkyl, cyano-C1-C6alkyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C2-C6alkenyl, C2-C6quinil, benzyl or C1-C6alkoxymethyl,

R4, R5, R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl, C3-C6cycloalkyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen and C1-C6alkyl, or phenyl, which is unsubstituted or one - or mnogosloinym and Zam is stitely which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C1-C6alkylamino and di-C1-C6alkylamino, or

R4and R5together denote C2-C6alkylen,

W represents O, S, S(O2or N(R9),

R9denotes hydrogen or C1-C6alkyl,

and denotes 1, 2, 3,or 4

b represents 0, 1, 2, 3 or 4 and

n denotes 0 or 1.

Alkyl as individual groups and as structural element of other groups and compounds, such as haloalkyl, alkylamino, alkoxygroup, allylthiourea, alkylsulfonyl and alkylsulfonyl, is in each case based on the number of carbon atoms in a particular group or a particular connection or remotemachine, for example, represents methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl or octyl, or branched, for example, represents isopropy is, isobutyl, sec-butyl, tert-butyl, isopentyl, neopentyl or isohexyl.

Cycloalkyl as individual groups and as structural element of other groups and compounds, such as halachically, cycloalkanes and cycloalkylation, represents in each case based on the number of carbon atoms in a particular group or a particular connection cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl.

Alkenyl as individual groups and as structural element of other groups and compounds-is, in each case based on the number of carbon atoms in a particular group or a particular connection and conjugated or isolated double bonds or remotemachine, for example, represents allyl, 2-butenyl, 3-pentenyl, 1-hexenyl, 1-heptenyl, 1,3-hexadienyl or 1,3-octadiene, or branched, for example, is Isopropenyl, Isobutanol, isoprenyl, tert-pentenyl, isohexanol, isoheptane or isooctanol.

Quinil as individual groups and as structural element of other groups and compounds-is, in each case based on the number of carbon atoms in a particular group or a particular connection and conjugated or isolated double bonds or remotemachine, for example, is a disappear to the Gil, 2-butenyl, 3-pentenyl, 1-hexenyl, 1-heptenyl, 3-HEXEN-1-inyl or 1.5-heptadien-3-inyl, or branched, for example, is a 3-methylbut-1-inyl, 4-ethylpent-1-inyl, 4-metrex-2-inyl or 2-methylhept-3-inyl.

Heteroaryl represents pyridyl, thienyl, furanyl, peril, benzothiazyl, benzofuranyl, indolyl or indazole, preferably pyridyl or thienyl, especially pyridyl.

Halogen generally represents fluorine, chlorine, bromine or iodine. The same applies to halogen ("halo"), which is the element of other groups and compounds, such as haloalkyl and halophenol.

Halogen-substituted carbon-containing groups and compounds may be partially halogenated or perhalogenated, with halogen substituents in the case of polygalacturonase may be identical or different. Examples of haloalkyl as individual groups and as structural element of other groups and compounds, such as haloalkoxy and haloalkylthio, are methyl, which as substituents contains from one to three fluorine atoms, chlorine and/or bromine, such as CHF2or CF3, ethyl, which as substituents contains from one to five fluorine atoms, chlorine and/or bromine, such as CH2CF3, CF2CF3, CF2CCl3, CF2CHCl2, CF2CHF2, CF 2CFCl2, CF2CHBr2, CF2CHClF, CF2CHBrF or CClFCHClF, propyl or isopropyl, each of which as substituents contains from one to seven fluorine atoms, chlorine and/or bromine, such as CH2CHBrCH2Br, CF2CHFCF3CH2CF2CF3or CH(CF3)2, butyl or one of its isomers, each of which as substituents contains from one to nine atoms of fluorine, chlorine and/or bromine, such as CF(CF3)CHFCF3or CH2(CF2)2CF3pencil or one of its isomers, each of which as substituents contains from one to eleven atoms of fluorine, chlorine and/or bromine, such as CF(CF3)(CHF)2CF3or CH2(CF2)3CF3and hexyl or one of its isomers, each of which as substituents contains from one to thirteen fluorine atoms, chlorine and/or bromine, for example (CH2)4CHBrCH2Br, CF2(CHF)4CF3CH2(CF2)4CF3or(CF3)2(CHF)2CF3.

Alkoxygroup preferably have a chain length of 1 to 6 carbon atoms. As examples of alkoxygroup can be called methoxy-, ethoxy-, propoxy-, isopropoxy, h-butoxy, isobutoxy-, second -, butoxy - and tert-butoxypropyl, as well as the isomers of pentyloxy and hexyloxy, prefer the ini thus methoxy - and ethoxypropan. Haloalkoxy preferably have a chain length of 1 to 6 carbon atoms. As examples of haloalkoxy can be called formatosi, deformedarse, triptoreline-, 2,2,2-triptoreline-, 1,1,2,2-tetrafluoroethoxy-, 2-floratone-, 2-chloroethoxy-, 2,2-diflorasone - and 2,2,2-trichlorethene, the preferred of which deformedarse-, 2-chloroethoxy and tripterocarpa.

Preferred according to the invention compounds are the following:

(1) compound of formula I, in which

Ar1and Ar2independently from each other represent unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenyl, halo,-C2-C6alkenyl, C2-C6quinil, C3-C6cycloalkyl, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonates, halo,-C1-C6alkylsulfonates, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6 alkylsulfonyl, halo-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylsulfonamides, halo,-C1-C6alkylsulfonamides, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted fenoxaprop either one or mnogozahodnoy fenoxaprop, substituents which may be independent is e from each other values and in turn selected from the group including halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea,C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted phenylacetylene either one or mnogozalny phenylacetylene, substituents which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, and an unsubstituted pyridyloxy either one or mnogozahodnoy pyridyloxy, substituents which may be independent from each other values and in turn selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alcox the group, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl,C1-C6alkylsulfonyl and halo-C1-C6alkylsulfonyl, unsubstituted or indicate heteroaryl either one or mnogozalny heteroaryl, substituents which may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino and di-C1-C6alkylamino, or represent unsubstituted naphthyl or chinolin either one or mnogozalny naphthyl or chenail, the substituents of which may have independent the Rog from each other values and selected from the group including halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C2-C6altertekhnogrupp, halo,-C2-C6altertekhnogrupp, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C2-C6alkanesulfonyl, halo,-C2-C6alkanesulfonyl, C1-C6alkylamino and di-C1-C6alkylamino,

Q1denotes CH2The co2, S, S(O), S(O2) or S(O)

Q2denotes a direct bond or C(O),

R3denotes hydrogen, C1-C6alkyl, halo,-C1-C6alkyl, cyano-C1-C6alkyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C2-C6alkenyl or C2-C6quinil,

R4, R5, R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl, C3-C6C is cloaker, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen and C1-C6alkyl, or phenyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulfonyl, halo,-C1-C6alkylsulfonyl, C1-C6alkylsulfonyl, halo-C1-C6alkylsulfonyl, C1-C6alkylamino and di - C1-C6alkylamino, or

R4and R5together denote C2-C6alkylen,

W represents O, S, S(O2or N(R9),

R9denotes hydrogen or C1-C6alkyl,

and denotes 1, 2, 3,or 4

b represents 0, 1, 2, 3 or 4 and

n denotes 0 or 1;

(2) the compound of the formula I in which Ar1and Ar2independently from each other represent unsubstituted phenyl or one or mnogozalny phenyl, the Deputy is which can be independent from each other values and selected from the group including halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenyl, halo,-C2-C6alkenyl, C2-C6quinil, C3-C6cycloalkyl, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl and di-C1-C6alkylaminocarbonyl, heteroaryl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylamino and di-C1-C6alkylamino, or naphthyl, which are the two which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylamino and di-C1-C6alkylamino primarily denote phenyl, which in each case independently is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C3-C6cycloalkyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl and di-C1-C6alkylaminocarbonyl, heteroaryl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be illegal is isinya from each other values and selected from the group including halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6alkylamino and di-C1-C6alkylamino, or naphthyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C1-C6alkylamino and di-C1-C6alkylamino, most preferably denotes phenyl, which in each case independently is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup and halo-C1-C6alkoxygroup, or heteroaryl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl and halo-C1-C6alkyl;

(a) a compound of the formula I, in which Q1denotes CH2, S, S(O2) or S(O), and especially(O);

(4) the compound of the formula I, in which R3denotes hydrogen, C1-C6alkyl, halo,-C1-C6alkyl, cyano-C1-C6alkyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C2-C6alkenyl or C2-C6quinil, primarily hydrogen or C1-C6alkyl, most preferably hydrogen;

(5) the compound of the formula I, in which R4, R5,R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl, C3-C6cycloalkyl or phenyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup and halo-C1-C6alkoxygroup, first of all, independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl or C3-C6cycloalkyl, most preferably independently of one another denote hydrogen, halogen, C1-C6alkyl or halo-C1-C6Ala is l;

(6) the compound of the formula I, in which W represents O, S or N(R9), especially O or N(R9), most preferably About;

(7) the compound of the formula I, in which R9denotes hydrogen or C1-C4alkyl, especially hydrogen or C1-C2alkyl, most preferably methyl;

(8) the compound of formula I, where and denotes 1, 2 or 4, especially 1 or 4, most preferably 1;

(9) the compound of the formula I in which b represents 0, 1, 2 or 4, especially 0, 1 or 4, most preferably 0 or 1;

(10) the compound of the formula I in which n denotes 0;

(11) the compound of the formula I, in which

Ar1and Ar2independently from each other represent unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenyl, halo,-C2-C6alkenyl, C2-C6quinil, C3-C6cycloalkyl, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylamino, di-C1-C6 alkylamino, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl and di-C1-C6alkylaminocarbonyl, heteroaryl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylamino and di-C1-C6alkylamino, or naphthyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo,-C1-C6alkoxygroup, C2-C6alkenylacyl, halo,-C2-C6alkenylacyl, C1-C6allylthiourea, halo,-C2-C6alkylthio is, C1-C6alkylamino and di-C1-C6alkylamino,

Q1denotes CH2, S, S(O2) or S(O)

R3denotes hydrogen or C1-C6alkyl,

R4, R5, R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl, C3-C6cycloalkyl or phenyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, a nitro-group, a cyano, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup and halo-C1-C6alkoxygroup,

W represents O, S or N(R9),

R9denotes hydrogen or C1-C4alkyl,

and denotes 1, 2 or 4,

b represents 0, 1, 2 or 4 and

n denotes 0;

(12) the compound of the formula I, in which

Ar1and Ar2independently of one another denote phenyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup, halo-C 1-C6alkoxygroup, C3-C6cycloalkyl, C1-C6allylthiourea, halo,-C1-C6allylthiourea, C1-C6alkylsulphonyl, halo,-C1-C6alkylsulphonyl, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl and di-C1-C6alkylaminocarbonyl,

Q1denotes C(O),

R3denotes hydrogen or C1-C2alkyl,

R4, R5, R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl, halo,-C1-C6alkyl or C3-C6cycloalkyl,

W represents O or N(R9),

R9denotes hydrogen or C1-C2alkyl,

and denotes 1 or 4,

b represents 0, 1 or 4 and

n denotes 0;

(13) the compound of the formula I, in which

Ar1and Ar2independently of one another denote phenyl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is substituted, may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl, halo,-C1-C6alkyl, C1-C6alkoxygroup and halo-C1-C6alkoxygroup, or heteroaryl, which is unsubstituted or one - or mnogosloinym and Vice which, if it is a Ki is substituted, can be independent from each other values and selected from the group comprising halogen, C1-C6alkyl and halo-C1-C6alkyl,

Q1denotes C(O),

R3denotes hydrogen,

R4, R5, R6, R7and R8independently of one another denote hydrogen, halogen, C1-C6alkyl or halo-C1-C6alkyl,

W represents O,

R9denotes methyl,

and denotes 1,

b denotes 0 or 1, and

n denotes 0.

According to the invention particularly preferred compounds of formula I listed in table 1, and first of all compounds described in the examples of synthesis.

The invention relates also to a method for producing compounds of formula I, respectively in free form or in salt form, which consists, for example, that the compound of the formula

which is a known compound or can be obtained analogously to corresponding known compounds and in which R3, R4, R5, R6, R7, R8, W, Ar2, a and b are specified for formula I values are cooperation, optionally in the presence of a basic catalyst, with a compound of the formula

which is a well known connection or you can get a similar is a rule corresponding known compounds and in which Ar 1, Q1, Q2and n have the above for formula I value, and X denotes a leaving group, and then, if necessary, the compound of formula I, obtained as described above or in any other way, respectively in free form or in salt form is converted into another compound of formula I, share obtained by this method a mixture of isomers and allocate the target isomer and/or a free compound of formula I, obtained as described above, transferred to salt or salt of the compounds of formula I, obtained as described above was transferred into the free compound of formula I or into another salt.

The above explanations about the salts of the compounds of formula I similarly apply to the salts of the parent compounds, the above and subsequent description.

When implementing the above method, the reagents can be interaction between them as such, i.e. without addition of a solvent or diluent, for example in the molten state. However, in most cases it may be appropriate to add to the reaction mixture an inert solvent or diluent or a mixture thereof. As examples of such solvents and diluents can be called aromatic, aliphatic and alicyclic hydrocarbons and halogenated hydrocarbons, such as benzene, toluene, xylene, IU is sustained fashion, tetralin, chlorobenzene, dichlorobenzene, Brabanthal, petroleum ether, hexane, cyclohexane, dichloromethane, trichloromethane, carbon tetrachloride, dichloroethane, trichloride or tetrachloride, ethers, such as diethyl ether, DIPROPYLENE ether, diisopropyl ether, disutility ether, tert-butyl methyl ether, onomatology ether of ethylene glycol, monotropy ether of ethylene glycol, dimethyl ether of ethylene glycol, dimethoxyethane ether, tetrahydrofuran or dioxane, ketones, such as acetone, methyl ethyl ketone or methyl isobutyl ketone, amides such as N,N-dimethylformamide, N,N-diethylformamide,N,N-dimethylacetamide, N is an organic or triamide hexamethylphosphoric acids, NITRILES, such as acetonitrile or propionitrile, and sulfoxidov, such as dimethylsulfoxide.

Preferred leaving groups are HE, halogen, tozilaty, mesylates and triflate, especially halogen, mainly chlorine.

As examples of bases suitable for catalysis carried out in accordance with the proposed invention by way of the reaction include hydroxides, hydrides, amides, alkanoate, acetates, carbonates, dialkylamides or alkylsilane alkaline or alkaline earth metals, bonds alkylamines, alkylenediamines, optionally N-alkylated, optionally unsaturated cyclooctylamine, heterocyclic bases, hydroxide ammonium, and carbocyclic amines. Specific examples of such bases include hydroxide, hydride, amide, methanolate, acetate and sodium carbonate, tert-butanolate, hydroxide, carbonate and potassium hydride, diisopropylamide lithium bis(trimethylsilyl)amide, potassium, calcium hydride, triethylamine, diisopropylethylamine, triethylenediamine, cyclohexylamine, N-cyclohexyl-N,N-dimethylamine, N,N-diethylaniline, pyridine, 4-(N,N-dimethylamino)pyridine, Hinkley, N-methylmorpholine, hydroxide designed, and 1,5-diazabicyclo[5.4.0]undec-5-ene (DBU).

The reaction is expediently carried out at a temperature of from about 0 to about 150°C, preferably from about 20 to about 100°C.

Salts of compounds of formula I can be obtained by a known method. So, for example, acid additive salts of compounds of the formula I get them treatment acceptable acid or suitable ion exchange reagent, and salts with bases - processing acceptable base or acceptable ion exchange reagent.

Salts of compounds of the formula I can in the usual way to turn into the free compounds of formula I, for which the acid-salt additive can, for example, to process acceptable to the principal agent or suitable ion exchange reagent, and salts with bases, for example, to process acceptable acid or suitable ion exchange reagent.

Depending on the specific methods and/or reaction conditions, the compounds of formula I having salt-forming properties can be obtained in free form or in the form of salts.

The compounds of formula I can also be obtained in the form of their hydrates and/or they may also contain molecules of other solvents, which, for example, may optionally be used for the crystallization of compounds represented in solid form.

Compounds of formulas I and II can be represented as one of the possible isomers or as mixtures thereof, for example depending on the number of asymmetric carbon atoms in the molecule and their absolute and relative configuration, they can exist in the form of pure isomers, such as antipodes and/or diastereoisomers, either in the form of mixtures of isomers, such as mixtures of enantiomers, such as racemates, mixtures of diastereoisomers the ditch or mixtures of racemates, thus the present invention relates to the pure isomers and to all possible mixtures of isomers, and therefore the above and subsequent description of such compounds includes their isomers and their mixtures, even if in each individual case and not given specific details regarding their stereochemical structure.

A mixture of diastereoisomers and mixtures of racemates of compounds of formulas I and II received proposed in the invention method, or other methods depending on the source materials and the technology selected, on the basis of differences in physico-chemical properties of the components of such mixtures to separate, for example, fractional crystallization, distillation and/or chromatography on a clean diastereoisomers or racemates.

Mixture of enantiomers, which are formed under appropriate conditions, such as racemates, can be divided by the known methods, for example by recrystallisation from an optically active solvent, by chromatography on chiral adsorbents, for example liquid chromatography high pressure (ghvd) on the cellulose acetate, using suitable for this purpose microorganisms, by cleavage with specific immobilised enzymes, or the formation of compounds including, for example using chiral crown ethers, in which case only one enantiomer which forms a complex.

In addition to the separation of corresponding mixtures of isomers according to the invention, there is also the opportunity to get well-known methods of diastereoselective or enantioselective synthesis of pure diastereoisomers or enantiomers, for example by inclusion in the proposed invention, a method of starting materials with the appropriate stereochemical structure.

In any case, it is preferable to select or synthesize biologically more active isomer, for example enantiomer, or mixture of isomers, such as a mixture of enantiomers, if the individual components have different biological activity.

In the proposed in the invention method, it is preferable to use those starting materials and intermediate products, which allow to obtain the compounds of formula I, which are presented in the beginning of the description as the most preferred.

The present invention relates, in particular, the variant of the method of obtaining the compounds described below in the example.

The present invention relates also to novel starting materials and intermediate products used according to the invention for preparing compounds of the formula I, to the use of these raw materials and intermediate products and the way they are received.

Offer and the acquisition of the compounds of formula I are characterized by a wide spectrum of activity and are valuable active substances, allowing the control of pests and parasites, including, in particular, combating endo - and ectoparasites in animals, and yet have a good tolerance of warm-blooded animals, fish and plants.

In the context of the present invention under the ectoparasites refers, in particular, insects and mites. Such parasites are insects of Lepidoptera, Coleoptera, Homoptera, Heteroptera, Diptera, Thysanoptera, Orthoptera, Anoplura, Siphonaptera, Mallophaga, Thysanura, Isoptera, Psocoptera and Hymenoptera. However, it should be noted those ectoparasites that "annoy" people or animals and which are carriers of pathogens, for example flies such as Musca domestica, Musca vetustissima, Musca autumnalis, Fannia canicularis, Sarcophaga carnaria, Lucilia cuprina, Hypoderma bovis, Hypoderma lineatum, Chrysomyia chloropyga, Dermatobia hominis, Cochliomyia hominivorax, Gasterophilus intestinalis. Oestrus ovis, Stomoxus calcitrans, Haematobia irritans, and small two-winged insects (Nematocera, dlinnoyu), such as Culicidae, Simuliidae, Psychodidae, as well as blood-sucking parasites, for example fleas, such as Ctenocephalides felis and Ctenocephalides canis (cat fleas and dog, respectively), Xenopsylla cheopis, Pulex irritans, Dermatophilus penetrans, lice, such as Damalina ovis, Pediculus humanis, stinging flies and horse flies (Tabanidae), Haematopota spp., such as Haematopota pluvialis, Tabanidea spp., such as Tabanus nigrovittatus, Chrysopsinae spp., such as Chrysops caecutiens, tsetse flies, such as species Glossinia, biting insects, particularly cockroaches, such as Blatella germanica, Blatta orientalis, Periplaneta aericana, and mites, such as Dermanyssus gallinae, Sarcoptes scabiei, Psoroptes ovis, Psorergates spp., including, but not limited to, Parasitiformes mites and other varieties. The latter belong to the order Acarina. As an example, well-known representatives of parasitovorax mites can be called Boophilus, Amblyomma, Anocentor, Dermacentor, Haemaphysails, Hyalomma, Ixodes, Rhipicentor, Margaropus, Rhipicephalus, Argas, Otobius, Ornithodoros, etc. that mainly infect warm-blooded animals, including farm animals, in particular cattle, pigs, sheep and goats, poultry, in particular chickens, turkeys and geese, farmed fur-bearing animals such as mink, foxes, chinchillas, rabbits and the like, as well as room and Pets, such as cats and dogs, and humans.

Proposed in the invention the compounds of formula I are also effective on all or individual stages of development not only with the normal sensitivity of pests, but also resistant pests, such as insects and representatives of the order Acarina. Insecticidal, ovicide and/or acaricidal action proposed in the invention of active substances can manifest itself directly, i.e. manifest in the destruction of pests and parasites, coming immediately after treatment or only after a certain period of time, for example during moulting, or destruction of their eggs, or opposed the bath, for example manifested in the reduction of the number of deposited eggs and/or the number of hatching from eggs of individuals, with good activity corresponds to the deaths of at least 50-60% of the pests.

The compounds of formula I can also be used for combating pests and parasites in the hygiene sector, especially to fight with representatives from the order Diptera families Sarcophagidae, Anophilidae and Culicidae, from the order Orthoptera, Dictyoptera (e.g., family Blattidae) and from the order Hymenoptera (e.g., family Formicidae).

The compounds of formula I can also effectively enough to combat mites and insects on the plants. Thus, in particular, when dealing with spider mites belonging to the order Acarina, these compounds can effectively destroy the eggs, nymphs and adults Tetranychidae (Tetranychus spp. Panonychus spp.).

Proposed in the invention compounds highly effective in the fight against sucking insects of the order Homoptera, primarily parasites of the families Aphididae, Delphacidae, Cicadellidae, Psyllidae, Loccidae, Diaspididae and Eriophydidae (for example, gall mites on citrus fruit crops) and of the orders Hemiptera, Heteroptera and Thysanoptera, and with herbivorous insects of the orders Lepidoptera, Coleoptera, Diptera and Orthoptera.

The proposed invention in connection equally can be used as a soil insecticide to Bo lby pests living in the soil.

The compounds of formula I, thus, are active at all stages of the development of sucking and herbivorous insect pests of cultivated plants, such as cereals, cotton, rice, corn, soybean, potato, vegetable crops, fruit crops, tobacco, hops, citrus crops, avocados and other crops.

The compounds of formula I can also effectively to combat parasitic on plants nematode species Meloidogyne, Heterodera, Pratylenchus, Ditylenchus, Radopholus, Rizoglyphus etc.

Proposed in the invention compounds are, in particular, an effective means of combating helminths, among which endoparasitic nematodes and trematodes can cause serious diseases in mammals and poultry, such as sheep, pigs, goats, cattle, horses, donkeys, dogs, cats, Guinea pigs and exotic birds. Typical representatives of such nematodes are At, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostonum, Oesophagostonum, Charbertia, Trichuris, Strongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis, Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxascaris and Parascaris. As an example of trematodes can, in particular, to refer to the members of the family Fasciolideae primarily Fasciola hepatica. A particular advantage of the compounds of the formula I is their effectiveness in the fight against those parasites who, which is not susceptible to the active substances on the basis of benzimidazole.

Some parasites belonging to the species of Nematodirus, Cooperia and Oesophagostonum, infect the intestines of an animal host, while others are parasites of the species At and Ostertagia, are parasites in the stomach, and parasites, referring to the form of Dictyocaulus, Lodge in the lung tissue. Parasites of the families Filariidae and Setariidae can be detected in the intracellular tissue and in various organs such as the heart, blood vessels, lymph vessels, and subcutaneous basis. It should be mention of this parasite parasite in the heart of dog worms Dirofilaria immitis. The compounds of formula I is highly effective in the fight against such parasites.

To parasites that can also fight using compounds of formula I, are parasites of the class Cestoda (tapeworms), for example members of the family Mesocestoidae, primarily of the genus Mesocestoides, in particular M. lineatus, family Dilepididae, first of all, Dipylidium caninum, Joyeuxiella spp., in particular Joyeuxiella pasquali, and Diplopylidium spp., and the family Taeniidae, first of all, Taenia pisiformis, Taenia cervi, Taenia ovis, Taenia hydatigena, Taenia multiceps, Taenia taeniaeformis, Taenia serialis and Echinocuccus spp., most preferably, Taenia hydatigena, Taenia ovis, Taenia multiceps, Taenia serialis, Echinococcus granulosus and Echinococcus multilocularis, as well as Multiceps multiceps.

Of particular note is the ability to fight with Taenia hydatigena, T. pisiformis, T. ovs, T. taeniaeformis, Multiceps multiceps, Joyeuxiella pasquali, Dipylidium caninum, Mesocestoides spp., Echinococcus granulosus and E. multilocularis in dogs and cats at the same time struggle with Dirofilaria immitis, Ancylostoma spp., Toxocara spp. and/or Trichuris vulpis. Equally preferred is the struggle against Ctenocephalides felis and/or .canis at the same time struggle with these nematodes and cestodes.

In addition, the compounds of formula I are suitable for combating pathogenic parasites in humans. Typical representatives of such parasites that live in the digestive tract, are parasites of the species Ancylostoma, Necator, Ascaris, Strongyloides, Trichinella, Capillaria, Trichuris and Enterobius. Proposed in the invention compounds may also be effectively used to combat parasites species Wuchereria, Brugia, Onchocerca and Loa from the family Filariidae that live in the blood, in different tissues and different organs, as well as for anti-parasite Dracunculus and parasites of the species Strongyloides and Trichinella, which, in particular, infect the gastrointestinal tract.

The compounds of formula I are also effective means of pest and pathogenic fungi on plants and in humans and animals.

High pesticidal activity proposed in the invention compounds of formula I is manifested in the destruction of at least 50-60% of the above mentioned pests from all of them. The compounds of formula I are distinguished, in particular, retain the amount within the exceptionally long period of time by the action.

The compounds of formula I are preferably used in unmodified form or, preferably, together with auxiliary substances commonly used in the technology for preparative forms, and therefore, such compounds can be processed by known techniques to obtain, for example, mulgirigala concentrates, directly dilutable solutions, dilute emulsions, soluble powders, granules, and microencapsulated in a polymer preparations. The type of drug, as well as methods of processing are selected in accordance with the objectives and the prevailing circumstances.

Preparative form, i.e. the compositions, compounds or mixtures containing the active substance of the formula I or of such active substances in combination with other active ingredients, and optionally a solid or liquid excipient, get a known method, for example by homogeneous mixing and/or grinding the active substances with extenders, for example solvents, solid carriers and optionally a surface-active substances (surfactants).

As the above solvents can be used, for example, alcohols, such as ethanol, propanol or butanol, glycols and their ethers and esters, such propylene glycol, dipropyleneglycol the IDF, ethylene glycol, onomatology or-ethyl ether of ethylene glycol, ketones, such as cyclohexanone, isophorone or diacetolol alcohol, strong polar solvents, such as N-methyl-2-pyrrolidone, dimethyl sulfoxide or dimethylformamide, or water, vegetable oils, such as rapeseed, castor, coconut or soya oil, and, when appropriate, silicone oils.

The preferred preparative forms for protection against helminths in warm-blooded animals are solutions, emulsions, suspensions (drugs for infusion into the oral cavity of the animal), feed additives, powders, tablets including effervescent tablets, pills, capsules, microcapsules and samarasekara forms for processing bulk, while in the manufacture of a drug should take into account the physiological compatibility included in the composition of the excipients.

As a binder in the manufacture of tablets and pills can be used chemically modified natural polymeric substances, soluble in water or in alcohol, such as starch, cellulose or derivatives of proteins (for example, methylcellulose, carboxymethylcellulose, metilgidroxiatilzelllozu such proteins, as Zein, gelatin and the like), as well as synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, etc. In the composition of the tablets includes the e fillers (for example, starch, microcrystalline cellulose, sugar, lactose, etc), lubricants and disintegrating agents.

If helminthology presented in the form of feed concentrates, in their composition as carriers include, for example, specialized feed (feed), feed grains or protein concentrates. Such feed concentrates or compositions in addition to the active substances may also contain additives, vitamins, antibiotics, chemotherapeutic agents or other pesticides, mainly bacteriostatic tools, mould tools, coccidiostatic tools, or even hormone preparations, substances having anabolic, or growth stimulating substances, which affect the quality of the meat slaughtered animals or to provide other beneficial effects on the body. Adding such compositions or contained active substances of formula I directly to the feed or in the drinking trough, it is preferable that the concentration of active substances in the product feed or drinking the composition was approximately from 0.0005 to 0.02 wt.% (5-200 ppm million).

Proposed in the invention the compounds of formula I can be used individually or in combination with other biocides. So, for example, to increase the effectiveness of these compounds can be combined with pesticides, bledowski the same action, or, for example, to broaden the spectrum of action of these compounds can be combined with substances that have a different action. In some cases, it may be advisable to add a so-called repellents. If you need to expand the range of actions, ensuring at the same time combating endoparasites, such as worms, the compounds of formula I it is advisable to combine with substances possessing protivoparazitarnymi properties. It is obvious that these compounds can also be used in combination with antibacterial agents. Since the compounds of formula I are adulticide", i.e. the effective mainly in the fight against parasites, fully reached the adult stage of development (adult stage), it may be appropriate to add them to the pesticides that are more effective at combating parasites in the earlier stages of their development. This way you can fight with most of the population of parasites that cause significant economic damage. In addition, the combined effect would greatly impede the development of such parasites resistance to the active substances. A large number of combination drugs may also show a synergistic effect, so it is possible to reduce the overall rate of de the existing substances what makes sense from an environmental point of view. A preferred group of active substances, and particularly preferred active substances, one or more of which may be used in combination with the compound of the formula I, described below.

Active ingredients suitable for use in a mixture with the proposed in the invention compounds are biocides such as insecticides and acaricides with different mechanism of action, which are listed below and are already quite well-known experts in this field, in particular chitin synthesis inhibitors, growth regulators, current-type juvenile hormone substances acting type adulticidal substances insecticide with a broad spectrum of action, acaricides with a wide range of actions and nematicides and well-known helminthology and deterring insects and/or mites substances, i.e. above repellents or drugs, providing smoothcriminal parasites from the skin.

As an example, suitable for use in combination with the proposed invention the compounds of insecticides and acaricides include the following (but not limited to):

1. the abamectin16. the toxin of Bacillus subtil.32. carbophenothion
2. AC 30363017. bendiocarb33. cartap
3. Arafat18. benfuracarb34. cloethocarb
4. acrinathrin19. bensultap35. chlorethoxyfos
5. alankar20. β-cyfluthrin36. chlorfenapyr
6. aldicarb21. bifenthrin37. chlorfluazuron
7. α-cypermethrin22. BFMC38. chlormephos
8. alphamethrin23. papenbrock39. the chlorpyrifos
9. amitraz24. bromophos And40. CIS-resmethrin
10. avermectin Bi25. bofenkampAle
11. AZ 6054126. buprofezin42. clofentezine
12. azinphos And27. butocarboxim43. cyanophos
13. azinphos M28. butylparaben44. cicloprofen
14. azinphos-methyl29. cadusafos45. cyfluthrin
15. azocyclotin30. carbaryl46. cyhexatin
31. the carbofuran47. D-2341
48. deltamethrin82. fipronil 113. methamidophos
49. demeton M83. fluazinam114. methiocarb
50. demeton S84. fluazuron115. methomyl
51. demeton-S-methyl85. flucycloxuron116. methoprene
52. dibutylamino86. flucythrinate117. metolcarb
53. dichlofenthion87. flufenoksuron118. mevinphos
54. declivous88. plutopress119. milbemectin
55. dition89. fonofos120. moxidectin
56. diflubenzuron90. formation121. naled
57. timeout91. fosthiazate122. NC 184
58. dimethylene92. tupfenrock123. NI-25, acetamiprid
59. dioxathion93. NSN124. nitenpyram
60. DPX-MP06294. heptenophos125. omethoate
61. edifenphos95. hexaflumuron126. oxamyl
62. emamectin96. hexythiazox127. oxydemeton M
63. endosulfan97. the hydroprene128. oxidation
64. esfenvalerate 98. Imidacloprid129. parathion
65. ethiofencarb99. insecticide active mushrooms130. parathion-methyl
66. ation131. permethrin
67. etofenprox100. insecticide132. pintout
68. ethoprophosactive nematodes133. port
69. etrimfos101. insecticide active viruses134. fosalan
70. fenamiphos135. phosmet
71. finishin102. iprobenfos136. phoxim
72. fenbutatin103. isofenphos137. pirimicarb
73. penetration104. isoprocarb138. pirimiphos And
74. fenobucarb105. isoxathion139. pirimiphos M
75. fanatical106. ivermectin140. promecarb
76. fenoxycarb107. λ-cigalotrin141. propafol
77. fenpropathrin108. lufenuron142. propoxur
78. feneral109. Malathion143. prothiofos
79. fenpyroximate110. mecarbam144. about the oat
80. fenthion111. resolvents145. pyraclofos
81. fenvalerate112. metaldehyde146. predatation
147. prismatron161. tebufenpyrad175. triuralin
148. feverfew162. tebupirimfos176. triazamate
149. pyridaben163. teflubenzuron177. triazophos
150. pyrimidifen164. tefluthrin178. treasure
151. pyriproxifen165. temephos179. trichlorfon
152. RH-5992166. terram180. triflumuron
153. RH-2485167. terbufos181. timetaken
154. coalition168. tetrachlorvinphos182. validation
155. sabots169. titanox183. KMK (3,5-xylylenediisocyanate)
156. selflove170. thiodicarb
157. spinosad171. thiofanox184. xiller
158. sulfotep172. thionazin185. YI 5301/5302
159. sulprofos173. thuringiensis186. ζ-cypermethrin
160. tebufenozide 174. tralomethrin187. decamethrin

Below are not limiting the scope of invention examples suitable for use according to the invention of helminthoides, some of which in addition to helminthoides action also possess insecticidal and acaricidal action and so partly mentioned in the above list:

(A1) praziquantel: 2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-α]isoquinoline;

(A2) closantel: 3,5-diid-N-[5-chloro-2-methyl-4-(a-cyano-4-Chlorobenzyl)phenyl]salicylamide;

(A3) triclabendazole: 5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole;

(A4) levamisol: L-(-)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1b]thiazole;

(A5) mebendazole: methyl ester (5-benzoyl-1H-benzimidazole-2-yl)carbamino acids;

(A6) omphalitis: macrocyclic enzymatic product of fungus Omphalotus olearius, described in WO 97/20857;

(A7) abamectin: avermectin B1;

(A8) ivermectin: 22,23-dihydroavermectin B1;

(A9) moxidectin: 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)milbemycin;

(A10) doramectin: 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl " avermectin A1a;

(A11) milbemectin: mixture milbemycin And3and milbemycin And4;

(A12) milbemycin: 5-oxime milbemectin.

Below do not exhaust unicefusa scope of the invention examples suitable for use according to the invention repellents and drugs providing smoothcriminal parasites from the skin:

(R1) DEET N,N-diethyl-m-toluamide;

(R2) KBR 3023: N-butyl-2-oxycarbonyl(2-hydroxy)piperidine;

(R3) Zemiata: N-2,3-dihydro-3-methyl-1,3-thiazol-2-ilidene-2,4-xylidene.

The above active substances that can be used in a mixture with the compounds according to the invention, the most well-known specialists in this field. Most of them are described in various publications Pesticide Manual, published by The British Crop Protection Council, London, and others described in various editions of The Merck Index, published by Merck & Co., Inc., Rahway, New Jersey, USA, or in the patent literature. With this in mind, the list below is limited to some publications, which in the example described above active ingredients:

(I) O-methylcarbamate 2-methyl-2-(methylthio)propionic aldehyde (aldicarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London, 1997, 11th ed., p.26;

(II) S-(3,4-dihydro-4-oksobenzo[d][1,2,3]triazine-3-ylmethyl)-O,O-dimethylphosphorodithioate (azinphos-methyl) is known from The Pesticide Manual, published by The British Crop Protection Council, London, 1997, 11th ed., p.67;

(III) ethyl-N-[2,3-dihydro-2,2-dimethylbenzofuran-7-jocstarbunny(methyl)aminothio]-N-isopropyl-β-alaninate (benfuracarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., pp.96;

(IV) 2-methylbiphenyl-3-ylmethyl-(Z)-(1RS)-CIS-3-(2-chloro-3,3,3-Cryptocom-1-the Nile)-2,2-dimethylcyclopropanecarboxylate (bifenthrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., pp.118;

(V) 2-tert-Butylimino-3-isopropyl-5-phenyl-1,3,5-thiadiazine-4th (buprofezin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(VI) 2,3-dihydro-2,2-dimethylbenzofuran-7-illecillewaet (carbofuran) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(VII) 2,3-dihydro-2,2-dimethylbenzofuran-7-yl(dibutylamino)methylcarbamate (carbosulfan) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(VIII) S,S'-(2-dimethylaminomethylene)bis(THIOCARBAMATE) (cartap) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(IX) 1-[3,5-dichloro-4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl]-3-(2,6-differentail)urea (chlorfluazuron) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(X) O,O-diethyl-O-3,5,6-trichloro-2-pyridylacetate (chlorpyrifos) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XI) (RS)-α-cyano-4-fluoro-3-phenoxybenzyl-(1RS,3RS;1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cyfluthrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s.293;

(XII) mixture of (S)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2-chloro-3,3,3-tryptophanyl)-2,2-dimethylcyclopropanecarboxylate (R)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2-chloro-3,3,3-tryptophanyl)-2,2-dimetallic is propanecarboxylate (λ -cigalotrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XIII) the racemate comprising (S)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate and (R)-α-cyano-3-phenoxybenzyl-(1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (α-cypermethrin), known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XIV) a mixture of the stereoisomers of (S)-α-cyano-3-phenoxybenzyl-(1RS,3RS;1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (ζ-cypermethrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XV) (S)-α-cyano-3-phenoxybenzyl-(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate (deltamethrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XVI) (4-chlorophenyl)-3-(2,6-differentail)urea (diflubenzuron) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XVII) (1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-rebismart)sulfite (endosulfan) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XVIII) α-ethylthio-o-trimethylarsine (ethiofencarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XIX) O,O-dimethyl-O-4-nitro-m-tolypocladium (fenitrothion) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XX) 2-second-butylphenylmethyl (fenobucarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXI) (RS)-α-cyano-3-phenoxybenzyl-(RS)-2-(4-chlorophenyl)-3-methylbutyrate (fenvalerate) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXII) S-[formyl(methyl)carbamoylmethyl]-O,O-dimethylphosphorodithioate (formation) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXIII) 4-methylthio-3,5-xylylenediisocyanate (methiocarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.813;

(XXIV) 7-chlorobicyclo[3.2.0]hepta-2,6-Dien-6-endimetriosis (heptenophos) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXV) 1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-imagenames (Imidacloprid) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXVI) 2-isopropylaminocarbonyl (isoprocarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXVII) O,S-dimethylphosphorodithioate (methamidophos) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXVIII) of S-methyl-N-(methylcarbamoyl)thioacetimidate (methomyl) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXIX) methyl-3-(diethoxyphosphoryloxy)but-2-ENOAT (mevinphos) is known from The Pesticide Manual, published by The British Crop Protection Coucil, London 1997, 11th ed., s;

(XXX) O,O-diethyl-O-4-nitrophenylphosphate (parathion) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXI) O,O-dimethyl-O-4-nitrophenylphosphate (parathion-methyl) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXII) S-6-chloro-2,3-dihydro-2-oxo-1,3-benzoxazol-3-ylmethyl-O,O-diethylphosphonate (vocalon) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXIII) 2-dimethylamino-5,6-dimethylpyrimidin-4-ultimatecarpage (pirimicarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXIV) 2-isopropoxybenzonitrile (propoxur) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXV) 1-(3,5-dichloro-2,4-differenl)-3-(2,6-differentail)urea (diflubenzuron) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXVI) S-tert-butylthioethyl-O,O-dimethylphosphorodithioate (terbufos) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXVII) ethyl(3-tert-butyl-1-dimethylcarbamoyl-1H-1,2,4-triazole-5-ylthio)acetate (triazamate) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XXXVIII) abamectin is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.3;

(XXXIX) 2-second-butylphenylmethyl (fenobucarb) is known from The Pesticide Manual, published in the British Crop Protection Council, London 1997, 11th ed., s;

(XL) N-tert-butyl-N'-(4-ethylbenzoyl)for 3,5-dimethylbenzophenone (tebufenozide) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., with,1147;

(XLI) (±)-5-amino-1-(2,6-dichloro-α,α,α-Cryptor-n-tolyl)-4-triftormetilfullerenov-3-carbonitrile (fipronil) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLII) (RS)-α-cyano-4-fluoro-3-phenoxybenzyl-(1RS,3RS;1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (β-cyfluthrin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLIII) (4-ethoxyphenyl)-[3-(4-fluoro-3-phenoxyphenyl)propyl] (dimethyl)silane (selfloader) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLIV) of tert-butyl(E)-α-(1,3-dimethyl-5-Phenoxyethanol-4-ylmethylamino)-n-toluate (fenpyroximate) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLV) 2-tert-butyl-5-(4-tert-butylbenzyl)-4-chloropyridin-3(2H)-he (pyridaben) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLVI) 4-[[4-(1,1-dimetilfenil)phenyl]ethoxy]hinzelin (fenazaquin) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLVII) 4-phenoxyphenyl-(RS)-2-(pyridyloxy)propyl ether (pyriproxyfen) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLVIII) 5-PI is the p-N-{2-[4-(2-ethoxyethyl)-2,3-dimethylphenoxy]ethyl}-6-ethylpyrimidine-4-amine (pyrimidifen) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(XLIX) (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitropyridinium (nitenpyram) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(L) (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamide (NI-25, acetamiprid) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.9;

(LI) avermectin B1known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.3;

(LII) insecticide active plant extract, especially (2R,6aS, 12aS)-1,2,6,6A,12,12A-hexahydro-2-Isopropenyl-8,9-dimethoxypropane[3,4-b]furo[2,3-h]chromen-6-he (rotenone), known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, and extract from Azadirachta indica, primarily azadirachtin known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.59;

(LIII) a preparation containing insecticide active nematodes, preferably containing Heterorhabditis bacteriophora and Heterorhabditis megidis, known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, Steinernema feltiae, known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, and Steinernema scapterisci, known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(LIV) preparation derived from Bacillus subtilis, known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.72, or the drug, n is obtainable from a strain of Bacillus thuringiensis, with the exception of the compounds selected from the strain GC91 or strain NCTC11821 known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(LV) product containing insecticide active mushrooms, preferably containing Verticillium lecanii and is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, Beauveria brogniartii known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., p.85, and Beauveria bassiana, is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(LVI) preparation containing insecticide active viruses, preferably containing a virus Neodipridon Sertifer NPV known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, virus Mamestra brassicae NPV known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s, and the virus of Cydia pomonella granulosis known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(CLXXXI) 7-chloro-2,3,4A,5-tetrahydro-2-[methoxycarbonyl(4-trifloromethyl)carbarnoyl]indole [1,2E]oxazoline-4-carboxylate (DPX-MR, indoxacarb) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(CLXXXII) N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzoate (RH-2485, methoxyfenozide) is known from The Pesticide Manual, published by The British Crop Protection Council, London 1997, 11th ed., s;

(CLXXXIII) isopropyl ether (N'-[4-methoxybiphenyl-3-yl]hydrazinecarboxamide acid (D 2341) known the EN of the Brighton Crop Protection Conference, 1996, s-493;

(R2) is known from the Book of Abstracts, 212th ACS National Meeting, Orlando, FL, 25-29 August 1996, AGRO-020, publisher: American Chemical Society, Washington, D.C. CONEN: 63BFAF.

Accordingly another object of the present invention are a combination of drugs to control parasites of warm-blooded animals, characterized in that they are in addition to the compounds of formula I contain at least one active ingredient having the same or a different action, and at least one physiologically acceptable carrier. It should be noted that the present invention is not limited to two combined drugs, i.e. drugs, containing only two active substances.

Normally offered in the invention helminthicide compositions contain from 0.1 to 99 wt.%, especially from 0.1 to 95 wt.%, the active substance of the formula I, from about 99.9 to 1 wt.%, first of all from and 99.8 to 5 wt.%, solid or liquid additive and 0 to 25 wt.%, first of all, from 0.1 to 25 wt.%, Surfactant.

Proposed in the invention compositions for the treatment of animals can be applied locally, orally, parenterally or subcutaneously, for which such compositions may be presented in the form of solutions, emulsions, suspensions (drugs for infusion into the oral cavity of the animal), powders, tablets, pills, capsules and samarasekara drugs to handle the loading.

The method is standing in applying samarasekara drugs to handle the loading point or processing, involves the application of the compounds of formula I in some local area of the skin or coat of the animal, mainly on his shoulder or back in the spine. This samarasekera agent for treatment of bulk or spot treatment is applied, for example, by using a swab or spray on a relatively small area of coat, where the active substance begins essentially automatically spread ("spread") over a large area along the skin or coat due to the presence of the drug components, promoting such distribution of the active substance, and this process of "self-propagating" the active substance is more intense due to the committed animal movements.

These samarasekara preparations for processing of bulk and spot treatment mainly contain media that provide rapid diffusion of the active substance on the skin or wool cover an animal host and are usually referred to as distributing oils. For this purpose can be used, for example, oil solutions, alcohol and isopropanol solutions, in particular solutions of 2-octyldodecanol or olejowego alcohol, solutions of esters of monocarboxylic acids, such as isopro elminister, isopropyl, lurileksua, alerby ester of oleic acid, decroly ester of oleic acid, exellent, aerolef, decillia and esters of Caproic acid and saturated fatty alcohols with a chain length of C12-C18the solutions of esters of dicarboxylic acids, such as dibutyl phthalate, diisopropylnaphthalene, diisopropyl ether, adipic acid and di-n-butylacetat, or solutions of esters of aliphatic acids, such as glycols. In the composition of these drugs may be useful to include also known dispersant used in the pharmaceutical or cosmetic industry. As an example, this can be called 2-pyrrolidone, 2-(N-alkyl)pyrrolidone, acetone, polyethylene glycol and its ethers and esters, propylene glycol or synthetic triglycerides.

Oil solutions contain, for example, vegetable oils such as olive oil, peanut oil, sesame oil, pine oil, linseed oil and castor oil. Vegetable oil can also be present in epoxydecane. In addition, you can also use paraffin and silicone oils.

Usually samarasekara preparations for processing of bulk and for spot treatment containing from 1 to 20 wt.% the compounds of formula I, from 0.1 to 50 wt.% dispersant and 45 to the 98.9 wt.% the solvent.

The method is standing in applying samarasekara drugs to handle the loading point or processing, it is preferable to use primarily for herd animals such as cattle, horses, sheep and pigs, when oral administration of the drug or a drug by injection each animal is a time-consuming procedure that is associated with a high expenditure of time. This method, which due to its simplicity can, obviously, be applied to all other animals, including individual home and Pets, has found widespread among pet owners because it allows frequent use without expert help of a veterinarian.

As provided in the sale of products is generally preferable compounds or compositions in the form of concentrates, while the end user typically uses diluted preparations.

Such preparations may also contain additional excipients, such as stabilizers, antispyware, viscosity regulators, binders or adhesives, and other active substances that achieve special effects.

Helminthicide compositions of this type used by the end consumer, are also the object of the present invention.

The active substances of the formula I, their use for combating parasites in any of the methods according to the invention or in part of any item is odnaznachno for these purposes, the composition of the invention can be used in all their spatial isomers or mixtures thereof.

In the present invention it is also proposed a method of preventive protection of warm-blooded animals, especially productive livestock, poultry and Pets, against parasitic helminths, characterized in that the active substances of formula I or obtained on the basis thereof and compositions containing them orally or by injection (parenteral) is administered to the animals as an additive to food or drink or in solid or liquid form. The present invention relates further to offer it to the compounds of formula I, intended for use in one of these methods.

Below the invention is illustrated in the examples, not limiting its scope, under the active substance refers to one of the compounds listed in table 1. Thus, in particular, the following composition is preferred compositions (preparative forms) (data in % correspond wt.%).

Examples of compositions (preparative forms)

1. Granules

a)b)
the active ingredient5%10%
kaolin94%-
highly dispersed silicic acid1%-
attapulgite-90%

D. actuuse substance is dissolved in methylene chloride and the resulting solution is sprayed on the carrier, then the solvent is evaporated in vacuum. These granules can be added to the feed for the animals.

2. Granules

the active ingredient3%
polyethylene glycol (200 MM)3%
kaolin94%
(MM denotes the molecular weight)

Finely ground active ingredient is uniformly served in the mixer to kaolin, oblastnomu polyethylene glycol. In this way receive a dust free granules coated.

3. Tablets or pills

I.the active ingredient33,00%
the methylcellulose0,80%
highly dispersed silicic acid0,80%
flour starch8,40%
II.crystalline lactose22,50%
flour starch17,00%
microcrystalline cellulose16,50%
magnesium stearate1,00%

I. Methylcellulose stir in the water. After swelling material primase which indicate the silicic acid and the resulting mixture is suspended until homogeneity. The active substance is mixed with flour starch. Then to this mixture add the above aqueous suspension and knead until pasty state. The resulting mass granularit by pushing through a sieve 12 mesh and dried.

II. Thoroughly mix between all 4 excipient.

III. The mixture previously obtained at stages I and II are mixed among themselves and pressed into tablets or pills.

4. Preparations for injection

A. Oil filler (slow release)
1.the active ingredient0.1 to 1.0 g
peanut butterto 100 ml
2.the active ingredient0.1 to 1.0 g
sesame oilto 100 ml

Receiving: active substance with stirring and, if necessary, with moderate heating is dissolved in part from just provided the recipe amount of oil and after cooling the solution volume was adjusted to the desired, and then sterilized by filtration through a suitable membrane filter with a pore size 0,22 mm

B. Mixed with water, the solvent (the average rate of release)

1.the active ingredient0.1 to 1.0 g
4-hydroxymethyl-1,3-dioxolane (nominally glycerol)40 g
1,2-propandiolto 100 ml
2.the active ingredient0.1 to 1.0 g
glyceryltrinitrate40 g
1,2-propandiolto 100 ml

Receiving: the active substance is dissolved under stirring in part from just provided the recipe the amount of the solvent, after which the volume of the solution was adjusted to the desired and then sterilized by filtration through a suitable membrane filter with a pore size 0,22 mm

Century Water solubilized (quick release)

1.the active ingredient0.1 to 1.0 g
polyethoxysiloxane castor oil (40 ethylenoxide links)10 g
1,2-propandiol20 g
benzyl alcohol : 1 g
water for injectionto 100 ml
2.the active ingredient 0.1 to 1.0 g
polyethoxysiloxane servicemanual (20 ethylenoxide links)8 g
4-hydroxymethyl-1,3-dioxolane (nominally glycerol)20 g
benzyl alcohol : 1 g
water for injectionto 100 ml

Receiving: the active substance is dissolved in a solvent and a surfactant, then the volume of the solution was adjusted to the required addition of water. Then, the solution is sterilized by filtration through a suitable membrane filter with a pore size 0,22 mm

5. Samarasekera preparation for processing bulk

A.the active ingredient5 g
isopropylmyristate10 g
isopropanolto 100 ml
B.the active ingredient2 g
exellent5 g
the triglyceride with an average chain length15 g
ethanolto 100 ml
Centurythe active ingredient2 g
aerolef5 g
N-organic40 g
isopropanolto 100 ml

Such water system preferably also be used for oral administration and/or for insertion into the rumen (intraluminal). Such compositions may also contain additional excipients, such as stabilizers, for example optional epoxydecane vegetable oils (in particular, epoxydecane coconut, canola or soybean oil), antispyware, for example silicone oil, preservatives, viscosity regulators, binders and adhesives, as well as fertilizers or other active substances that achieve special effects.

In the composition described above compositions can also include other biologically active substances or additives, which has a neutral properties with respect to compounds of formula I and do not have undesirable effects on being treated with animal-owner, as well as mineral salts or vitamins.

Below the invention is illustrated in the examples. These examples do not limit the scope of the invention. The abbreviation "h" indicates the time in hours.

Examples retrieve

Example 1: 4-benzoyl-N-[1-cyano-1-methyl-2-(2-cryptomite is phenoxy)ethyl]benzamide

330 mg of benzophenone-4-carboxylic acid are dissolved in 6 ml of dichloromethane, and then added 283 mg of the hydrochloride of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide, 18 mg of 4-dimethylaminopyridine and 222 mg of ethyldiethanolamine and stirred for 20 min at room temperature. Then add 300 mg of 2-amino-2-methyl-3-(2-triptoreline)propionitrile and the mixture is stirred for 40 hours Then the mixed solution was washed with aqueous sodium bicarbonate solution, then 1 N. hydrochloric acid and finally with a saturated solution of sodium chloride. After that, the organic phase is separated, dried over sodium sulfate, filtered and concentrated by evaporation. After recrystallization in diethyl ether as the remainder receive 372 mg specified in the title compound with a melting point 121-123°C.

Similarly, the above method can also obtain the compounds listed below in table 1. In this table, the values of the melting temperature (tPLquoted in °C. "Communication" refers to a direct link, i.e. the link 3-Ar1" indicates the relationship between the 3-position of the phenyl ring and Ar1.

Table 1

No.Ar1/td> Ar2WQlnQ2Physical. har-Ki
1.1With6H5With6H5About4-CH20
1.2With6H5With6H5About3-CH20
1.3With6H5With6H5About2-CH20
1.4With6H5With6H5About4-och20
1.5With6H5With6H5About3-och30
1.6With6H5With6H5About2-och20
1.7With6H5With6H5About4-S0
1.8With6H5With6H5About3-S0
1.9With6H5With6H5About2-S0
1.10With6H5With6H5About4-S(O)0
1.11With6H5With6H5About3-S(O)0
1.12With6H5With6H5About2-S(O)0
1.13With6H5With6H5About4-C(O)0
1.14With6H4With6H5About4-C(O)1communication 3-Ar1
1.15With6H4With6H5About4-C(O)13-C(Oh)
1.6 With6H4With6H5About4-C(O)13-S(O2)
1.17With6H5With6H5About3-C(Oh)0
1.18With6H4With6H5About3-C(Oh)1nexus 4-Ar1
1.19With6H4With6H5About3-C(Oh)14-S(O2)
1.20With6H5With6H5About2-C(O)0
1.21With6H4With6H5About2-C(O)1communication 3-Ar1
1.22With6H4With6H5About2-C(O)13-C(Oh)
1.23With6H4With6H5About2-C(O)13-S(O2)
1.24With6H5With6H5S4-CH20
1.25With6H5With6H5S3-CH20
1.26With6H5With6H5S2-CH20
1.27With6H5With6H5S4-och20
1.28With6H5With6H5S3-och30
1.29With6H5With6H5S2-och20
1.30With6H5With6H5S4-S0
1.31With6H5With6H5S3-S
1.32With6H5With6H5S2-S0

3-C(Oh)
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.33With6H5With6H5S4-S(O)0
1.34With6H5With6H5S3-S(O)0
1.35With6H5With6H5S2-S(O)0
1.36With6H5With6H5S4-C(O)0
1.37With6H4With6H5S4-C(O)1communication 3-Ar1
1.38With6H4With6H5/td> S4-C(O)13-C(Oh)
1.39With6H4With6H5S4-C(O)13-S(O2)
1.40With6H5With6H5S3-C(Oh)0
1.41With6H4With6H5S3-C(Oh)1nexus 4-Ar1
1.42With6H4With6H5S3-C(Oh)14-S(O2)
1.43With6H5With6H5S2-C(O)0
1.44With6H4With6H5S2-C(O)1communication 3-Ar1
1.45With6H4With6H5S2-C(O)13-C(Oh)
1.46With6H4 With6H5S2-C(O)13-S(O2)
1.47With6H5With6H4-2-ClAbout4-CH20
1.48With6H5With6H4-2-ClAbout3-CH20
1.49With6H5With6H4-2-ClAbout2-CH20
1.50With6H5With6H4-2-ClAbout4-och20
1.51With6H5With6H4-2-ClAbout3-och20
1.52With6H5With6H4-2-ClAbout2-och20
1.53With6H5With6H4-2-ClAbout4-S0
1.54With6H5With6H4-2-ClAbout3-S0
1.55With6H5With6H4-2-ClAbout2-S0
1.56With6H5With6H4-2-ClAbout4-S(O)0
1.57With6H5With6H4-2-ClAbout3-S(O)0
1.58With6H5With6H4-2-ClAbout2-S(O)0
1.59With6H5With6H4-2-ClAbout4-C(O)0tPL90-93°
1.60With6H4With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.61With6H4With6H4-2-ClAbout4-C(O)1
1.62With6H4With6H4-2-ClAbout4-C(O)13-S(O2)
1.63With6H5With6H4-2-ClAbout3-C(Oh)0
1.64With6H4With6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.65With6H4With6H4-2-ClAbout3-C(Oh)14-S(O2)
1.66With6H5With6H4-2-ClAbout2-C(O)0
1.67With6H4With6H4-2-ClAbout2-C(O)1Communication 3-Ar1
1.68With6H4With6H4-2-ClAbout2-C(O)13-C(Oh)
1.69With6H4With6H4-2-Cl About2-C(O)13-S(O2)
1.70With6H5With6H4-2-ClS4-CH20
1.71With6H5With6H4-2-ClS3-CH20
1.72With6H5With6H4-2-ClS2-CH20
1.73With6H5With6H4-2-ClS4-och20

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.74With6H5With6H4-2-ClS3-och20
1.75With6H5With6H4-2-ClS2-och20
1.76With6H5With6H4-2-ClS4-S0
1.77With6H5With6H4-2-ClS3-S0
1.78With6H5With6H4-2-ClS2-S0
1.79With6H5With6H4-2-ClS4-S(O)0
1.80With6H5With6H4-2-ClS3-S(O)0
1.81With6H5With6H4-2-ClS2-S(O)0
1.82With6H5With6H4-2-ClS4-C(O)0tPL109-110°
1.83With6H4With6H4-2-ClS4-C(O)1 1
1.84With6H4With6H4-2-ClS4-C(O)13-C(Oh)
1.85With6H4With6H4-2-ClS4-C(O)13-S(O2)
1.86With6H5With6H4-2-ClS3-C(O)0
1.87With6H4With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.88With6H4With6H4-2-ClS3-C(Oh)14-S(O2)
1.89With6H5With6H4-2-ClS2-C(O)0
1.90With6H4With6H4-2-ClS2-C(O)1communication 3-Ar1
1.91With6H4With6H4-2-Cl S2-C(O)13-C(Oh)
1.92With6H4With6H4-2-ClS2-C(O)13-S(O2)
1.93With6H5With6H4-2-CF3About4-CH20
1.94With6H5With6H4-2-CF3About3-CH20
1.95With6H5With6H4-2-CF3About2-CH20
1.96With6H5With6H4-2-CF3About4-och20tPL44-48°
1.97With6H5With6H4-2-CF3About3-OCH20
1.98With6H5With6H4-2-CF3About2-och20
1.99With6H5With6H4-2-CF3About4-S0
1.100With6H5With6H4-2-CF3About3-S0
1.101With6H5With6H4-2-CF3About2-S0
1.102With6H5With6H4-2-CF3About4-S(O)0
1.103With6H5With6H4-2-CF3About3-S(O)0
1.104With6H5With6H4-2-CF3About2-S(O)0
1.105With6H5With6H4-2-CF3About4-C(O)0tPL121-123°
1.106With6H4 With6H4-2-CF3About4-C(O)1communication 3-Ar1
1.107With6H4With6H4-2-CF3About4-C(O)13-C(Oh)tPL74-78°
1.108With6H4With6H4-2-CF3About4-C(O)13-S(O2)tPL207-210°
1.109With6H5With6H4-2-CF3About3-C(O)0
1.110With6H4With6H4-2-CF3About3-C(Oh)1nexus 4-Ar1tPL90-93°
1.111With6H4With6H4-2-CF3About3-C(Oh)14-S(O2)
1.112With6H5With6H4-2-CF3About2-C(O)0
1.113With6H4With6H4 3About2-C(O)1communication 3-Ar1
1.114With6H4With6H4-2-CF3About2-C(O)13-C(Oh)

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.115With6H4With6H4-2-CF3About2-C(O)13-S(O2)
1.116With6H5With6H4-2-CF3S4-CH20
1.117With6H5With6H4-2-CF3S3-CH30
1.118With6H5With6H4-2-CF3S2-CH20
1.119With6H5With6H4-2-CF3S 4-och20
1.120With6H5With6H4-2-CF3S3-och20
1.121With6H5With6H4-2-CF3S2-och20
1.122With6H5With6H4-2-CF3S4-S0
1.123With6H5With6H4-2-CF3S3-S0
1.124With6H5With6H4-2-CF3S2-S0
1.125With6H5With6H4-2-CF3S4-S(O)0
1.126With6H5With6H4-2-CF3S3-S(O)0
1.127With6H5With6H4-2-CF3S2-S(O)0
1.128With6H5With6H4-2-CF3S4-C(O)0
1.129With6H4With6H4-2-CF3S4-C(O)1communication 3-Ar1
1.130With6H4With6H4-2-CF3S4-C(O)13-C(Oh)
1.131With6H4With6H4-2-CF3S4-C(O)13-S(O2)
1.132With6H5With6H4-2-CF3S3-C(Oh)0
1.133With6H4With6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.134With6H4With6H4-2-CF 3S3-C(Oh)14-S(O2)
1.135With6H5With6H4-2-CF3S2-C(O)0
1.136With6H4With6H4-2-CF3S2-C(O)1communication 3-Ar1
1.137With6H4With6H4-2-CF3S2-C(O)13-C(Oh)
1.138With6H4With6H4-2-CF3S2-C(O)13-S(O2)
1.139With6H4-4-FWith6H5About4-CH20
1.140With6H4-4-FWith6H5About3-CH20
1.141With6H4-4-FWith6H5About2-CH20
1.142With6H4-4-FWith6H5About4-och20
1.143With6H4-4-FWith6H5About3-och20
1.144With6H4-4-FWith6H5About2-och20
1.145With6H4-4-FWith6H5About4-S0
Number 1,146With6H4-4-FWith6H5About3-S0
1.147With6H4-4-FWith6H5About2-S0
1.148With6H4-4-FWith6H5About4-S(O)0
1.149With6H4-4-FWith6H5About3-S(O) 0
1.150With6H4-4-FWith6H5About2-S(O)0
1.151With6H4-4-FWith6H5About4-C(O)0
1.152With6H3-4-FWith6H5About4-C(O)1communication 3-Ar1
1.153With6H3-4-FWith6H5About4-C(O)13-C(Oh)
1.154With6H3-4-FWith6H5About4-C(O)13-S(O2)
1.155With6H4-4-FWith6H5About3-C(Oh)0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.156With6H3 -4-FWith6H5About3-C(Oh)1nexus 4-Ar1
1.157With6H3-4-FWith6H5About3-C(Oh)14-S(O2)
1.158With6H4-4-FWith6H5About2-C(O)0
1.159With6H3-4-FWith6H5About2-C(O)1communication 3-Ar1
1.160With6H3-4-FWith6H5About2-C(O)13-C(Oh)
1.161With6H3-4-FWith6H5About2-C(O)13-S(O2)
1,162 noticesWith6H4-4-FWith6H5S4-CH20
1.163With6H4-4-FWith6H5S3-CH20
1.164With6H4-4-FWith6H5S2-CH20
1.165With6H4-4-FWith6H5S4-och20
1.166With6H4-4-FWith6H5S3-och20
1.167With6H4-4-FWith6H5S2-och20
1.168With6H4-4-FWith6H5S4-S0
1.169With6H4-4-FWith6H5S3-S0
1.170With6H4-4-FWith6H5S2-S0
1.171With6H4-4-FWith6H5S4-S(O) 0
1.172With6H4-4-FWith6H5S3-S(O)0
1.173With6H4-4-FWith6H5S2-S(O)0
1.174With6H4-4-FWith6H5S4-C(O)0
1.175With6H3-4-FWith6H5S4-C(O)1communication 3-Ar1
1.176With6H3-4-FWith6H5S4-C(O)13-C(Oh)
1.177With6H3-4-FWith6H5S4-C(O)13-S(O2)
1.178With6H4-4-FWith6H5S3-C(Oh)0
1.179With6H3-4-FWith6H5S 3-C(Oh)1nexus 4-Ar1
1.180With6H3-4-FWith6H5S3-C(Oh)14-S(O2)
1.181With6H4-4-FWith6H5S2-C(O)0
1.182With6H3-4-FWith6H5S2-C(O)1communication 3-Ar1
1.183With6H3-4-FWith6H5S2-C(O)13-C(Oh)
1.184With6H3-4-FWith6H5S2-C(O)13-S(O2)
1.185With6H4-4-FWith6H4-2-ClAbout4-CH20
1.186With6H4-4-FWith6H4-2-ClAbout3-CH20
1.187 6H4-4-FWith6H4-2-ClAbout2-CH20
1.188With6H4-4-FWith6H4-2-ClAbout4-och20
1.189With6H4-4-FWith6H4-2-ClAbout3-och20
1.190With6H4-4-FWith6H4-2-ClAbout2-och20
1.191With6H4-4-FWith6H4-2-ClAbout4-S0
1.192With6H4-4-FWith6H4-2-ClAbout3-S0
1.193With6H4-4-FWith6H4-2-ClAbout2-S0
1.194With6H4-4-FWith6H4-2-ClAbout4-S(O)0
1.195With6H4-4-FWith6H4-2-ClAbout3-S(O)0
1.196With6H4-4-FWith6H4-2-ClAbout2-S(O)0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.197C6H4-4-FWith6H4-2-ClAbout4-C(O)0
1.198With6H3-4-FWith6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.199With6H3-4-FWith6H4-2-ClAbout4-C(O)13-C(Oh)
1.200With6H3-4-FWith6H4-2-ClAbout4-C(O)13-S(O2)
1.201C6H4 -4-FWith6H4-2-ClAbout3-C(Oh)0
1.202With6H3-4-FWith6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.203With6H3-4-FWith6H4-2-ClAbout3-C(Oh)14-S(O2)
1.204C6H4-4-FWith6H4-2-ClAbout2-C(O)0
1.205With6H3-4-FWith6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.206With6H3-4-FWith6H4-2-ClAbout2-C(O)13-C(Oh)
1.207With6H3-4-FWith6H4-2-ClAbout2-C(O)13-S(O2)
1.208C6H4-4-FWith6H4-2-ClS4-CH20
1.209C6H4-4-FWith6H4-2-ClS3-CH20
1.210C6H4-4-FWith6H4-2-ClS2-CH20
1.211C6H4-4-FWith6H4-2-ClS4-och20
1.212C6H4-4-FWith6H4-2-ClS3-och20
1.213C6H4-4-FWith6H4-2-ClS2-och20
1.214C6H4-4-FWith6H4-2-ClS4-S0
1.215C6H4-4-FWith6H4-2-ClS3-S0
1.216C6H4-4-FWith6H4-2-Cl S2-S0
1.217C6H4-4-FWith6H4-2-ClS4-S(O)0
1.218C6H4-4-FWith6H4-2-ClS3-S(O)0
1.219C6H4-4-FWith6H4-2-ClS2-S(O)0
1.220C6H4-4-FWith6H4-2-ClS4-C(O)0
1.221C6H4-4-FWith6H4-2-ClS4-C(O)1communication 3-Ar1
1.222With6H3-4-FWith6H4-2-ClS4-C(O)13-C(Oh)
1.223With6H3-4-FWith6H4-2-ClS4-C(O)13-S(O2)
1.224C6H4 -4-FWith6H4-2-ClS3-C(Oh)0
1.225With6H3-4-FWith6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.226With6H3-4-FWith6H4-2-ClS3-C(Oh)14-S(O2)
1.227C6H4-4-FWith6H4-2-ClS2-C(O)0
1.228With6H3-4-FWith6H4-2-ClS2-C(O)1communication 3-Ar1
1.229With6H3-4-FWith6H4-2-ClS2-C(O)13-C(Oh)
1.230With6H3-4-FWith6H4-2-ClS2-C(O)13-S(O2)
1.231C6H4-4-FWith6H4-2-CF3About4-CH20
Of 1,232C6H4-4-FWith6H4-2-CF3About3-CH20
1.233C6H4-4-FWith6H4-2-CF3About2-CH20
1.234C6H4-4-FWith6H4-2-CF3About4-och20
1.235C6H4-4-FWith6H4-2-CF3About3-och20
1.236C6H4-4-FWith6H4-2-CF3About2-och20
1.237C6H4-4-FWith6H4-2-CF3About4-S0

td align="left"> 2-C(O)td align="left"> 2-C(O)
No.Ar1Ar2WQ1nQ2is ISIC. har-Ki
1.238With6H4-4-FWith6H4-2-CF3About3-S0
1.239With6H4-4-FWith6H4-2-CF3About2-S0
1.240With6H4-4-FWith6H4-2-CF3About4-S(O)0
1.241With6H4-4-FWith6H4-2-CF3About3-S(O)0
1.242With6H4-4-FWith6H4-2-CF3AboutO0
1.243With6H4-4-FWith6H4-2-CF3About4-C(O)0
1.244With6H3-4-FWith6H4-2-CF3About4-C(O)1communication 3-Ar1
1.245With6H3-4-Fthe 6H4-2-CF3About4-C(O)13-C(Oh)
1.246With6H3-4-FWith6H4-2-CF3About4-C(O)13-S(O2)
1.247With6H4-4-FWith6H4-2-CF3About3-C(Oh)0
1.248With6H3-4-FWith6H4-2-CF3About3-C(Oh)1nexus 4-Ar1
1.249With6H3-4-FWith6H4-2-CF3About3-C(Oh)14-S(O2)
1.250With6H4-4-FWith6H4-2-CF3About2-C(O)0
1.251With6H3-4-FWith6H4-2-CF3About2-C(O)1communication 3-Ar1
1.252With6H3-4-FWith6H4-2-CF3About13-C(Oh)
1.253With6H3-4-FWith6H4-2-CF3About2-C(O)13-S(O2)
1.254With6H4-4-FWith6H4-2-CF3S4-CH20
1.255With6H4-4-FWith6H4-2-CF3S3-CH20
1.256With6H4-4-FWith6H4-2-CF3S2-CH20
1.257With6H4-4-FWith6H4-2-CF3S4-och20
1.258With6H4-4-FWith6H4-2-CF3S3-och20
1.259With6H4-4-FWith6H4-2-CF3S2-och20
1.260With6H4-4-FWith6H4-2-CF3S4-S0
1.261With6H4-4-FWith6H4-2-CF3S3-S0
Absorbance 1.262With6H4-4-FWith6H4-2-CF3S2-S0
1.263With6H4-4-FWith6H4-2-CF3S4-S(O)0
1.264With6H4-4-FWith6H4-2-CF3S3-S(O)0
1.265With6H4-4-FWith6H4-2-CF3S2-S(O)0
1.266With6H4-4-FWith6H4-2-CF3S4-C(O)0
1.267With6H3-4-F With6H4-2-CF3S4-C(O)1communication 3-Ar1
1.268With6H3-4-FWith6H4-2-CF3S4-C(O)13-C(Oh)
1.269With6H3-4-FWith6H4-2-CF3S4-C(O)13-S(O2)
1.270With6H4-4-FWith6H4-2-CF3S3-C(Oh)0
1.271With6H3-4-FWith6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.272With6H3-4-FWith6H4-2-CF3S3-C(Oh)14-S(O2)
1.273With6H4-4-FWith6H4-2-CF3S2-C(O)0
1.274With6H3-4-FWith6H4-2-CF3S1communication 3-Ar1
1.275With6H3-4-FWith6H4-2-CF3S2-C(O)13-C(Oh)
1.276With6H3-4-FWith6H4-2-CF3S2-C(O)13-S(O2)
1.277With6H4-4-ClWith6H5About4-CH20
1.278With6H4-4-ClWith6H5About3-CH20

0
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.279With6H4-4-ClWith6H5About2-CH20
1.280With6H4-4-ClWith6H5About4-och20 /td>
1.281With6H4-4-ClWith6H5About3-och30
1.282With6H4-4-ClWith6H5About2-och20
1.283With6H4-4-ClWith6H5About4-S0
1.284With6H4-4-ClWith6H5About3-S0
1.285With6H4-4-ClWith6H5About2-S0
1.286With6H4-4-ClWith6H5About4-S(O)0
1.287With6H4-4-ClWith6H5About3-S(O)0
1.288With6H4-4-ClWith6H5About2-S(O)
1.289With6H4-4-ClWith6H5About4-C(O)0
1.290With6H3-4-ClWith6H5About4-C(O)1communication 3-Ar1
1.291With6H3-4-ClWith6H5About4-C(O)13-C(Oh)
1.292With6H3-4-ClWith6H5About4-C(O)13-S(O2)
1.293With6H4-4-ClWith6H5About3-C(Oh)0
1.294With6H3-4-ClWith6H5About3-C(Oh)1nexus 4-Ar1
1.295With6H3-4-ClWith6H5About3-C(Oh)14-S(O2)
1.296With6H4-4-ClWith6/sub> H5About2-C(O)0
1.297With6H3-4-ClWith6H5About2-C(O)1communication 3-Ar1
1.298With6H3-4-ClWith6H5About2-C(O)13-C(Oh)
1.299With6H3-4-ClWith6H5About2-C(O)13-S(O2)
1.300With6H4-4-ClWith6H5S4-CH20
1.301With6H4-4-ClWith6H5S3-CH20
1.302With6H4-4-ClWith6H5S2-CH20
1.303With6H4-4-ClWith6H5S4-och20
1.304With6H4-4-ClWith6H5S3-och20
1.305With6H4-4-ClWith6H5S2-och20
1.306With6H4-4-ClWith6H5S4-S0
1.307With6H4-4-ClWith6H5S3-S0
1.308With6H4-4-ClWith6H5S2-S0
1.309With6H4-4-ClWith6H5S4-S(O)0
1.310With6H4-4-ClWith6H5S3-S(O)0
1.311With6H4-4-ClWith6H5S2-S(O)01.312With6H4-4-ClWith6H5S4-C(O)0
1.313With6H3-4-ClWith6H5S4-C(O)1communication 3-Ar1
1.314With6H3-4-ClWith6H5S4-C(O)13-C(Oh)
1.315With6H3-4-ClWith6H5S4-C(O)13-S(O2)
1.316With6H4-4-ClWith6H5S3-C(Oh)0
1.317With6H3-4-ClWith6H5S3-C(Oh)1nexus 4-Ar1
1.318With6H3-4-ClWith6H5S3-C(Oh)14-S(O2)
1.319With6H4-4-ClWith6H5S 2-C(O)0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.320With6H3-4-ClWith6H5S2-C(O)1communication 3-Ar1
1.321With6H3-4-ClWith6H5S2-C(O)13-C(Oh)
1.322With6H3-4-ClWith6H5S2-C(O)13-S(O2)
1.323With6H4-4-ClWith6H4-2-ClAbout4-CH20
1.324With6H4-4-ClWith6H4-2-ClAbout3-CH20
1.325With6H4-4-ClWith6H4-2-ClAbout2-CH20
1.326With6H4-4-ClWith6H4-2-ClAbout4-och20
1.327With6H4-4-ClWith6H4-2-ClAbout3-och20
1.328With6H4-4-ClWith6H4-2-ClAbout2-och20
1.329With6H4-4-ClWith6H4-2-ClAbout4-S0
1.330With6H4-4-ClWith6H4-2-ClAbout3-S0
1.331With6H4-4-ClWith6H4-2-ClAbout2-S0
1.332With6H4-4-ClWith6H4-2-ClAbout4-S(O)0
1.333With6H4-4-ClWith6H4-2-ClAbout0
1.334With6H4-4-ClWith6H4-2-ClAbout2-S(O)0
1.335With6H4-4-ClWith6H4-2-ClAbout4-C(O)0
1.336With6H3-4-ClWith6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.337With6H3-4-ClWith6H4-2-ClAbout4-C(O)13-C(Oh)
1.338With6H3-4-ClWith6H4-2-ClAbout4-C(O)13-S(O2)
1.339With6H4-4-ClWith6H4-2-ClAbout3-C(Oh)0
1.340With6H3-4-ClWith6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.341With6sub> 3-4-ClWith6H4-2-ClAbout3-C(Oh)14-S(O2)
1.342With6H4-4-ClWith6H4-2-ClAbout2-C(O)0
1.343With6H3-4-ClWith6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.344With6H3-4-ClWith6H4-2-ClAbout2-C(O)13-C(Oh)
1.345With6H3-4-ClWith6H4-2-ClAbout2-C(O)13-S(O2)
1.346With6H4-4-ClWith6H4-2-ClS4-CH20
1.347With6H4-4-ClWith6H4-2-ClS3-CH20
1.348With6H4-4-ClWith6H4-2-ClS2-CH2
1.349With6H4-4-ClWith6H4-2-ClS4-och20
1.350With6H4-4-ClWith6H4-2-ClS3-och20
1.351With6H4-4-ClWith6H4-2-ClS2-och20
1.352With6H4-4-ClWith6H4-2-ClS4-S0
1.353With6H4-4-ClWith6H4-2-ClS3-S0
1.354With6H4-4-ClWith6H4-2-ClS2-S0
1.355With6H4-4-ClWith6H4-2-ClS4-S(O)0
1.356With6H4-4-ClWith6 H4-2-ClS3-S(O)0
1.357With6H4-4-ClWith6H4-2-ClS2-S(O)0
1.358With6H4-4-ClWith6H4-2-ClS4-C(O)0
1.359With6H3-4-ClWith6H4-2-ClS4-C(O)1communication 3-Ar1
1.360With6H3-4-ClWith6H4-2-ClS4-C(O)13-C(Oh)

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.361With6H3-4-ClWith6H4-4-ClS4-C(O)13-S(O2)
1.362With6H4-4-ClWith6H4-4-ClS3-C(Oh)0
1.363With6H3-4-ClWith6H4-4-ClS3-C(Oh)1nexus 4-Ar1
1.364With6H3-4-ClWith6H4-4-ClS3-C(Oh)14-S(O2)
1.365With6H4-4-ClWith6H4-4-ClS2-C(O)0
1.366With6H3-4-ClWith6H4-4-ClS2-C(O)1communication 3-Ar1
1.367With6H3-4-ClWith6H4-4-ClS2-C(O)13-C(Oh)
1.368With6H3-4-ClWith6H4-4-ClS2-C(O)13-S(O2)
1.369With6H4-4-ClWith6H4-2-CF3About4-CH20
1.370With6H4-4-Cl With6H4-2-CF3About3-CH20
1.371With6H4-4-ClWith6H4-2-CF3About2-CH20
1.372With6H4-4-ClWith6H4-2-CF3About4-och20
1.373With6H4-4-ClWith6H4-2-CF3About3-och20
1.374With6H4-4-ClWith6H4-2-CF3About2-och20
1.375With6H4-4-ClWith6H4-2-CF3About4-S0
1.376With6H4-4-ClWith6H4-2-CF3About3-S0
1.377With6H4-4-ClWith6H4-2-CF3 About2-S0
1.378With6H4-4-ClWith6H4-2-CF3About4-S(O)0
1.379With6H4-4-ClWith6H4-2-CF3About3-S(O)0
1.380With6H4-4-ClWith6H4-2-CF3About2-S(O)0
1.381With6H4-4-ClWith6H4-2-CF3About4-C(O)0
1.382With6H3-4-ClWith6H4-2-CF3About4-C(O)1communication 3-Ar1
1.383With6H3-4-ClWith6H4-2-CF3About4-C(O)13-C(Oh)
1.384With6H3-4-ClWith6H4-2-CF3About4-C(O)13-S(O2)
1.385With6H4-4-ClWith6H4-2-CF3About3-C(Oh)0
1.386With6H3-4-ClWith6H4-2-CF3About3-C(Oh)1nexus 4-Ar1
1.387With6H3-4-ClWith6H4-2-CF3About2-C(Oh)14-S(O2)
1.388With6H4-4-ClWith6H4-2-CF3About2-C(O)0
1.389With6H3-4-ClWith6H4-2-CF3About2-C(O)1communication 3-Ar1
1.390With6H3-4-ClWith6H4-2-CF3About2-C(O)13-C(Oh)
1.391With6H3-4-ClWith6H4-2-CF3About2-C(O)13-S(O2)
1.392 With6H4-4-ClWith6H4-2-CF3S4-CH20
1.393With6H4-4-ClWith6H4-2-CF3S3-CH20
1.394With6H4-4-ClWith6H4-2-CF3S2-CH20
1.395With6H4-4-ClWith6H4-2-CF3S4-och20
1.396With6H4-4-ClWith6H4-2-CF3S3-och20
1.397With6H4-4-ClWith6H4-2-CF3S2-och20
1.398With6H4-4-ClWith6H4-2-CF3S4-S0
1.399With6H4-4-Cl 6H4-2-CF3S3-S0
1.400With6H4-4-ClWith6H4-2-CF3S2-S0
1.401With6H4-4-ClWith6H4-2-CF3S4-S(O)0

C6H5
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.402C6H4-4-ClWith6H4-2-CF3S3-S(O)0
1.403C6H4-4-ClWith6H4-2-CF3S2-S(O)0
1.404C6H4-4-ClWith6H4-2-CF3S4-C(O)0
1.405C6H3-4-ClWith6H4-2-CF3S4-the(O) 1communication 3-Ar1
1.406C6H3-4-ClWith6H4-2-CF3S4-C(O)13-C(Oh)
1.407C6H3-4-ClWith6H4-2-CF3S4-C(O)13-S(O2)
1.408C6H4-4-ClWith6H4-2-CF3S3-C(Oh)0
1.409C6H3-4-ClWith6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.410C6H3-4-ClWith6H4-2-CF3S3-C(Oh)14-S(O2)
1.411C6H4-4-ClWith6H4-2-CF3S2-C(O)0
1.412C6H3-4-ClWith6H4-2-CF3S2-C(O)1communication 3-Ar1
1.413With6H3-4-ClWith6H4-2-CF3S2-C(O)13-C(Oh)
1.414C6H3-4-ClWith6H4-2-CF3S2-C(O)13-S(O2)
1.415C6H4-4-CH3C6H5About4-CH20
1.416C6H4-4-CH3C6H5About3-CH20
1.417C6H4-4-CH3C6H5About2-CH20
1.418C6H4-4-CH3C6H5About4-och20
1.419C6H4-4-CH3C6H5About3-och20
1.420C6H4-4-CH 3C6H5About2-och20
1.421C6H4-4-CH3C6H5About4-S0
1.422C6H4-4-CH3C6H5About3-S0
1.423C6H4-4-CH3C6H5About2-S0
1.424C6H4-4-CH3C6H5About4-S(O)0
1.425C6H4-4-CH3C6H5About3-S(O)0
1.426C6H4-4-CH3C6H5About2-S(O)0
1.427C6H4-4-CH3C6H5About4-C(O)0
1.428C6H3-4-CH3C6H5About4-C(O)1communication 3-Ar1
1.429C6H3-4-CH3C6H5About4-C(O)13-C(Oh)
1.430C6H3-4-CH3C6H5About4-C(0)13-S(O2)
1.431C6H3-4-CH3C6H5About3-C(Oh)0
1.432C6H3-4-CH3C6H5About3-C(Oh)1nexus 4-Ar1
1.433C6H3-4-CH3C6H5About3-C(Oh)14-S(O2)
1.434C6H4-4-CH3C6H5About2-C(O)0
1.435C6H3-4-CH3About2-C(O)1communication 3-Ar1
1.436C6H3-4-CH3C6H5About2-C(O)13-C(Oh)
1.437C6H3-4-CH3C6H5About2-C(O)13-S(O2)
1.438C6H4-4-CH3C6H5S4-CH20
1.439C6H4-4-CH3C6H5S3-CH20
1.440C6H4-4-CH3C6H5S2-CH20
1.441C6H4-4-CH3C6H5S4-och20
1.442C6H4-4-CH3C6H5S3-och2 0

3-C(Oh) 1
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.443C6H4-4-CH3With6H5S2-och20
1.444C6H4-4-CH3With6H5S4-S0
1.445C6H4-4-CH3With6H5S3-S0
1.446C6H4-4-CH3With6H5S2-S0
1.447C6H4-4-CH3With6H5S4-S(O0
1.448C6H4-4-CH3With6H5S3-S(O)0
1.449 C6H4-4-CH3With6H5S2-S(O)0
1.450C6H4-4-CH3With6H5S4-C(O)0
1.451C6H3-4-CH3With6H5S4-C(O)1communication 3-Ar1
1.452C6H3-4-CH3With6H5S4-C(O)13-C(Oh)
1.453C6H3-4-CH3With6H5S4-C(O)13-S(O2)
1.454C6H3-4-CH3With6H5S3-C(Oh)0
1.455C6H3-4-CH3With6H5S3-C(Oh)1nexus 4-Ar1
1.456C6H3-4-CH3With6H5S14-S(O2)
1.457C6H4-4-CH3With6H5S2-C(O)0
1.458C6H3-4-CH3With6H5S2-C(O)1communication 3-Ar1
1.459C6H3-4-CH3With6H5S2-C(O)13-C(Oh)
1.460C6H3-4-CH3With6H5S2-C(O)13-S(O2)
1.461C6H4-4-CH3With6H4-2-ClAbout4-CH20
1.462C6H4-4-CH3With6H4-2-ClAbout3-CH20
1.463C6H4-4-CH3With6H4-2-ClAbout2-CH20#x0200A;
1.464C6H4-4-CH3With6H4-2-ClAbout4-och20
1.465C6H4-4-CH3With6H4-2-ClAbout3-och20
1.466C6H4-4-CH3With6H4-2-ClAbout2-och20
1.467C6H4-4-CH3With6H4-2-ClAbout4-S0
1.468C6H4-4-CH3With6H4-2-ClAbout3-S0
1.469C6H4-4-CH3With6H4-2-ClAbout2-S0
1.470C6H4-4-CH3With6H4-2-ClAbout4-S(O)0
1.471C6H4-4-CH3 With6H4-2-ClAbout3-S(O)0
1.472C6H4-4-CH3With6H4-2-ClAbout2-S(O)0
1.473C6H4-4-CH3With6H4-2-ClAbout4-C(O)0
Including 1,474C6H3-4-CH3With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.475C6H3-4-CH3With6H4-2-ClAbout4-C(O)13-C(Oh)
1.476C6H3-4-CH3With6H4-2-ClAbout4-C(0)13-S(O2)
1.477C6H3-4-CH3With6H4-2-ClAbout3-C(Oh)0
1.478C6H3-4-CH3With6H4-2-ClAbout3-C(Oh)nexus 4-Ar1
1.479C6H3-4-CH3With6H4-2-ClAbout3-C(Oh)14-S(O2)
1.480C6H4-4-CH3With6H4-2-ClAbout2-C(O)0
1.481C6H3-4-CH3With6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.482C6H3-4-CH3With6H4-2-ClAbout2-C(O)13-C(Oh)
1.483C6H3-4-CH3With6H4-2-ClAbout2-C(O)13-S(O2)

td align="left"> 4-C(O)/tr>
No.Ar1Ar2WQ1NQ2Physical. har-Ki
1.484C6H4-4-CH3With6H4-2-ClS4-CH20
1.485C6H4-4-CH3With6H4-2-ClS3-CH30
1.486C6H4-4-CH3With6H4-2-ClS2-CH20
1.487C6H4-4-CH3With6H4-2-ClS4-och20
1.488C6H4-4-CH3With6H4-2-ClS3-och30
1.489C6H4-4-CH3With6H4-2-ClS2-och20
1.490C6H4-4-CH3With6H4-2-ClS4-S0
1.491C6H4-4-CH3With6H4-2-ClS3-S0
1.492 C6H4-4-CH3With6H4-2-ClS2-S0
1.493C6H4-4-CH3With6H4-2-ClS4-S(O)0
1.494C6H4-4-CH3With6H4-2-ClS3-S(O)0
1.495C6H4-4-CH3With6H4-2-ClS2-S(O)0
1.496C6H4-4-CH3With6H4-2-ClS4-C(O)0
1.497C6H4-4-CH3With6H4-2-ClS4-C(O)1communication 3-Ar1
1.498C6H4-4-CH3With6H4-2-ClS4-C(O)13-C(Oh)
1.499C6H4-4-CH3With6H4-2-ClS13-S(O2)
1.500C6H4-4-CH3With6H4-2-ClS3-C(Oh)0
1.501C6H4-4-CH3With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.502C6H4-4-CH3With6H4-2-ClS3-C(Oh)14-S(O2)
1.503C6H4-4-CH3With6H4-2-ClS2-C(O)0
1.504C6H3-4-CH3With6H4-2-ClS2-C(O)1communication 3-Ar1
1.505C6H3-4-CH3With6H4-2-ClS2-C(O)13-C(Oh)
1.506C6H3-4-CH3With6H4-2-ClS2-C(O)13-S(O2)
1.507C6H4-4-CH3With6H4-2-CF3About4-CH20
1.508C6H4-4-CH3With6H4-2-CF3About3-CH20
1.509C6H4-4-CH3With6H4-2-CF3About2-CH20
1.510C6H4-4-CH3With6H4-2-CF3About4-och20
1.511C6H4-4-CH3With6H4-2-CF3About3-och20
1.512C6H4-4-CH3With6H4-2-CF3About2-och20
1.513C6H4-4-CH3With6H4-2-CF3About4-S0&x0200A;
1.514C6H4-4-CH3With6H4-2-CF3About3-S0
1.515C6H4-4-CH3With6H4-2-CF3About2-S0
1.516C6H4-4-CH3With6H4-2-CF3About4-S(O)0
1.517C6H4-4-CH3With6H4-2-CF3About3-S(O)0
1.518C6H4-4-CH3With6H4-2-CF3About2-S(O)0
Consideration of 1,519C6H4-4-CH3With6H4-2-CF3About4-C(O)0
1.520C6H3-4-CH3With6H4-2-CF3About4-C(O)1communication 3-Ar1
1.521C6H3-4-CH3With6H4-2-CF3About4-C(O)13-C(Oh)
1.522C6H3-4-CH3With6H4-2-CF3About4-C(O)13-S(O2)
Of 1.523C6H3-4-CH3With6H4-2-CF3About3-C(Oh)0
1.524C6H3-4-CH3With6H4-2-CF3About3-C(Oh)1nexus 4-Ar1

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.525C6H3-4-CH3With6H4-2-CF3About3-C(Oh)14-S(O2)
1.526C6H4-4-CH3With6H4-2-CF3About2-C(O)0Ȁ
1.527C6H3-4-CH3With6H4-2-CF3About2-C(O)1communication 3-Ar1
1.528C6H3-4-CH3With6H4-2-CF3About2-C(O)13-C(Oh)
1.529C6H3-4-CH3With6H4-2-CF3About2-C(O)13-S(O2)
1.530C6H4-4-CH3With6H4-2-CF3S4-CH20
1.531C6H4-4-CH3With6H4-2-CF3S3-CH20
1.532C6H4-4-CH3With6H4-2-CF3S2-CH20
1.533C6H4-4-CH3With6H4-2-CF3S4-och20
1.534C6H4-4-CH3With6H4-2-CF3S3-och20
1.535C6H4-4-CH3With6H4-2-CF3S2-och20
1.536C6H4-4-CH3With6H4-2-CF3S4-S0
1.537C6H4-4-CH3With6H4-2-CF3S3-S0
1.538C6H4-4-CH3With6H4-2-CF3S2-S0
1.539C6H4-4-CH3With6H4-2-CF3S4-S(O)0
1.540C6H4-4-CH3With6H4-2-CF3S3-S(O)0
1.541C6H4-4-CH3With6H4-2-CF3S2-S(O)0
1.542C6H4-4-CH3With6H4-2-CF3S4-C(O)0
1.543C6H3-4-CH3With6H4-2-CF3S4-C(O)1communication 3-Ar1
1.544C6H3-4-CH3With6H4-2-CF3S4-C(O)13-C(Oh)
1.545C6H3-4-CH3With6H4-2-CF3S4-C(O)13-S(O2)
1.546C6H3-4-CH3With6H4-2-CF3S3-C(Oh)0
1.547C6H3-4-CH3With6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.548C6H3-4-CH3With6H4-2-CF3S3-C(Oh)14-S(O2)
1.549C6H4-4-CH3With6H4-2-CF3S2-C(O)0
1.550C6H3-4-CH3With6H4-2-CF3S2-C(O)1communication 3-Ar1
1.551C6H3-4-CH3With6H4-2-CF3S2-C(O)13-C(Oh)
1.552C6H3-4-CH3With6H4-2-CF3S2-C(O)13-S(O2)
1.553C6H4-4-OCH3With6H5About4-CH20
1.554C6H4-4-OCH3With6H5About3-CH20
1.555C6H4-4-OCH3With6H5About2-CH20
1.556C6H4-4-OCH3With6H5About4-och20
1.557C6H4-4-OCH3With6H5About3-och20
1.558C6H4-4-OCH3With6H5About2-och20
1.559C6H4-4-OCH3With6H5About4-S0
1.560C6H4-4-OCH3With6H5About3-S0
1.561C6H4-4-OCH3With6H5About2-S0
1.562C6H4-4-OCH3With6H5/sub> About4-S(O)0
1.563C6H4-4-OCH3With6H5About3-S(O)0
1.564C6H4-4-OCH3With6H5About2-S(O)0
1.565C6H4-4-OCH3With6H5About4-C(O)0

4-C(O)
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.566With6H3-4-och3With6H5About4-C(O)1communication 3-Ar1
1.567With6H3-4-och3With6H5About4-C(O)13-C(Oh)
1.568With6H3-4-och3With6H5About4-C(O) 13-S(O2)
1.569With6H4-4-och3With6H5About3-C(Oh)0
1.570With6H3-4-och3With6H5About3-C(Oh)1nexus 4-Ar1
1.571With6H3-4-och3With6H5About3-C(Oh)14-S(O2)
1.572With6H4-4-och3With6H5About2-C(O)0
1.573With6H3-4-och3With6H5About2-C(O)1communication 3-Ar1
1.574With6H3-4-och3With6H5About2-C(O)13-C(Oh)
1.575With6H3-4-och3With6H5About2-C(O)13-S(O2)Ȋ
1.576With6H4-4-och3With6H5S4-CH20
1.577With6H4-4-och3With6H5S3-CH20
1.578With6H4-4-och3With6H5S2-CH20
1.579With6H4-4-och3With6H5S4-och20
1.580With6H4-4-och3With6H5S3-och20
1.581With6H4-4-och3With6H5S2-och20
1.582With6H4-4-och3With6H5S4-S0
1.583sub> 6H4-4-och3With6H5S3-S0
1.584With6H4-4-och3With6H5S2-S0
1.585With6H4-4-och3With6H5S4-S(O)0
1.586With6H4-4-och3With6H5S3-S(O)0
1.587With6H4-4-och3With6H5S2-S(O)0
1.588With6H4-4-och3With6H5S4-C(O)0
1.589With6H3-4-och3With6H5S4-C(O)1communication 3-Ar1
1.590With6H3-4-och3With6H5S13-C(Oh)
1.591With6H3-4-och3With6H5S4-C(O)13-S(O2)
1.592With6H4-4-och3With6H5S3-C(Oh)0
1.593With6H3-4-och3With6H5S3-C(Oh)1nexus 4-Ar1
1.594With6H3-4-och3With6H5S3-C(Oh)14-S(O2)
1.595With6H4-4-och3With6H5S2-C(O)0
1.596With6H3-4-och3With6H5S2-C(O)1communication 3-Ar10
1.597With6H3-4-och3With6H5S2-C(O)13-C(Oh)ÈA;
1.598With6H3-4-och3With6H5S2-C(O)13-S(O2)
1.599With6H4-4-och3With6H4-2-ClAbout4-CH20
1.600With6H4-4-och3With6H4-2-ClAbout3-CH20
1.601With6H4-4-och3With6H4-2-ClAbout2-CH20
1.602With6H4-4-och3With6H4-2-ClAbout4-och20
1.603With6H4-4-och3With6H4-2-ClAbout3-och20
1.604With6H4-4-och3With6H4-2-ClAbout2-och20
1.605With6H4-4-och3With6H4-2-ClAbout4-S0
1.606With6H4-4-och3With6H4-2-ClAbout3-S0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.607With6H4-4-och3With6H4-2-ClAbout2-S0
1.608With6H4-4-och3With6H4-2-ClAbout4-S(O)0
1.609With6H4-4-och3With6H4-2-ClAbout3-S(O)0
1.610With6H4-4-och3With6H4-2-ClAbout2-S(O)0
1.611With6H4-4-och 3With6H4-2-ClAbout4-C(O)0
1.612With6H3-4-och3With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.613With6H3-4-och3With6H4-2-ClAbout4-C(O)13-C(Oh)
1.614With6H3-4-och3With6H4-2-ClAbout4-C(O)13-S(O2)
1.615With6H4-4-och3With6H4-2-ClAbout3-C(Oh)0
1.616With6H3-4-och3With6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.617With6H3-4-och3With6H4-2-ClAbout3-C(Oh)14-S(O2)
1.618With6H4-4-och3With H4-2-ClAbout2-C(O)0
1.619With6H3-4-och3With6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.620With6H3-4-och3With6H4-2-ClAbout2-C(O)13-C(Oh)
1.621With6H3-4-och3With6H4-2-ClAbout2-C(O)13-S(O2)
1.622With6H4-4-och3With6H4-2-ClS4-CH20
1.623With6H4-4-och3With6H4-2-ClS3-CH20
1.624With6H4-4-och3With6H4-2-ClS2-CH20
1.625With6H4-4-och3With6H4-2-Cl S4-och20
1.626With6H4-4-och3With6H4-2-ClS3-och20
1.627With6H4-4-och3With6H4-2-ClS2-och20
1.628With6H4-4-och3With6H4-2-ClS4-S0
1.629With6H4-4-och3With6H4-2-ClS3-S0
1.630With6H4-4-och3With6H4-2-ClS2-S0
1.631With6H4-4-och3With6H4-2-ClS4-S(O)0
1.632With6H4-4-och3With6H4-2-ClS3-S(O)0
1.633With6H4-4-och3With6H4-2-ClS2-S(O)0
1.634With6H4-4-och3With6H4-2-ClS4-C(O)0
1.635With6H3-4-och3With6H4-2-ClS4-C(O)1communication 3-Ar1
1.636With6H3-4-och3With6H4-2-ClS4-C(O)13-C(Oh)
1.637With6H3-4-och3With6H4-2-ClS4-C(O)13-S(O2)
1.638With6H4-4-och3With6H4-2-ClS3-C(Oh)0
1.639With6H3-4-och3With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.640With6H3-4-och3With6H4-2-ClS3-C(Oh)14-S(O2)
1.641With6H4-4-och3With6H4-2-ClS2-C(O)0
1.642With6H3-4-och3With6H4-2-ClS2-C(O)1communication 3-Ar1
1.643With6H3-4-och3With6H4-2-ClS2-C(O)13-C(Oh)
1.644With6H3-4-och3With6H4-2-ClS2-C(O)13-S(O2)
1.645With6H4-4-och3With6H4-2-CF3O4-CH20
1.646With6H4-4-och3With6H4-2-CF3O3-CH20
1.647 With6H4-4-och3With6H4-2-CF3O2-CH20

No.Ar1Ar2WQ1NQ2Physical. har-Ki
1.648With6H4-4-och3With6H4-2-CF3About4-och20
1.649With6H4-4-och3With6H4-2-CF3About3-och20
1.650With6H4-4-och3With6H4-2-CF3About2-och20
1.651With6H4-4-och3With6H4-2-CF3About4-S0
1.652With6H4-4-och3With6H4-2-CF3About3-S0
1.653With6H4-4-och3With6H4-2-CF3About2-S0
1.654With6H4-4-och3With6H4-2-CF3About4-S(O0
1.655With6H4-4-och3With6H4-2-CF3About3-S(O)0
1.656With6H4-4-och3With6H4-2-CF3About2-S(O)0
1.657With6H4-4-och3With6H4-2-CF3About4-C(O)0
1.658With6H3-4-och3With6H4-2-CF3About4-C(O)1communication 3-Ar1
1.659With6H3-4-och3With6H4-2-CF3About4-C(O)13-C(Oh)
1.660With6H3-4-och3With6H4-2-CF3About4-C(O)13-S(O2)
1.661With6H4-4-och3With6H4-2-CF3About3-C(Oh)0
1.662With6H3-4-och3With6H4-2-CF3About3-C(Oh)1nexus 4-Ar1
1.663With6H3-4-och3With6H4-2-CF3About3-C(Oh)14-S(O2)
1.664With6H4-4-och3With6H4-2-CF3About2-C(O)0
1.665With6H3-4-och3With6H4-2-CF3About2-C(O)1communication 3-Ar1
1.666With6H3-4-och3With6H4-2-CF3About2-C(O)1 3-C(Oh)
Done with 1,667With6H3-4-och3With6H4-2-CF3About2-C(O)13-S(O2)
1.668With6H4-4-och3With6H4-2-CF3S4-CH20
1.669With6H4-4-och3With6H4-2-CF3S3-CH20
1.670With6H4-4-och3With6H4-2-CF3S2-CH20
1.671With6H4-4-och3With6H4-2-CF3S4-och20
1.672With6H4-4-och3With6H4-2-CF3S3-och20
1.673With6H4-4-och3With6H4-2-CF3 S2-och20
1.674With6H4-4-och3With6H4-2-CF3S4-S0
1.675With6H4-4-och3With6H4-2-CF3S3-S0
1.676With6H4-4-och3With6H4-2-CF3S2-S0
1.677With6H4-4-och3With6H4-2-CF3S4-S(O)0
1.678With6H4-4-och3With6H4-2-CF3S3-S(O)0
1.679With6H4-4-och3With6H4-2-CF3S2-S(O)0
Of 1,680With6H4-4-och3With6H4-2-CF3S 4-C(O)0
1.681With6H3-4-och3With6H4-2-CF3S4-C(O)1communication 3-Ar1
1.682With6H3-4-och3With6H4-2-CF3S4-C(O)13-C(Oh)
1.683With6H3-4-och3With6H4-2-CF3S4-C(O)13-S(O2)
1.684With6H4-4-och3With6H4-2-CF3S3-C(Oh)0
1.685With6H3-4-och3With6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.686With6H3-4-och3With6H4-2-CF3S3-C(Oh)14-S(O2)
1.687With6H4-4-och3With6H4-2-CF3 S2-C(O)0
1.688With6H3-4-och3With6H4-2-CF3S2-C(O)1communication 3-Ar1

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.689With6H3-4-och3With6H4-2-CF3S2-C(O)13-C(Oh)
1.690With6H3-4-och3With6H4-2-CF3S2-C(O)13-S(O2)
1.691With6H4-4-CF3With6H5About4-CH20
1.692With6H4-4-CF3With6H5About3-CH20
1.693With6H4-4-CF3With6H 5About2-CH20
1.694With6H4-4-CF3With6H5About4-och20
1.695With6H4-4-CF3With6H5About3-och20
1.696With6H4-4-CF3With6H5About2-och20
1.697With6H4-4-CF3With6H5About4-S0
1.698With6H4-4-CF3With6H5About3-S0
1.699With6H4-4-CF3With6H5About2-S0
1.700With6H4-4-CF3With6H5About4-S(O)0
1.701With6H4-4-CF3With6H5About3-S(O)0
1.702 flats totallyWith6H4-4-CF3With6H5About2-S(O)0
1.703With6H4-4-CF3With6H5About4-C(O)0tPL146°
1.704With6H4-4-CF3With6H5About4-C(O)1communication 3-Ar1
1.705With6H4-4-CF3With6H5About4-C(O)13-C(Oh)
1.706With6H4-4-CF3With6H5About4-C(O)13-S(O2)
1.707With6H4-4-CF3With6H5About3-C(Oh)0
1.708With6H4/sub> -4-CF3With6H5About3-C(Oh)1nexus 4-Ar1
1.709With6H4-4-CF3With6H5About3-C(Oh)14-S(O2)
1.710With6H4-4-CF3With6H5About2-C(O)0
1.711With6H4-4-CF3With6H5About2-C(O)1communication 3-Ar1
1.712With6H4-4-CF3With6H5About2-C(O)13-C(Oh)
1.713With6H4-4-CF3With6H5About2-C(O)13-S(O2)
1.714With6H4-4-CF3With6H5S4-CH20
1.715With6H4-4-CF3With6H5 S3-CH20
1.716With6H4-4-CF3With6H5S2-CH20
1.717With6H4-4-CF3With6H5S4-och20
1.718With6H4-4-CF3With6H5S3-och20
1.719With6H4-4-CF3With6H5S2-och20
1.720With6H4-4-CF3With6H5S4-S0
1.721With6H4-4-CF3With6H5S3-S0
1.722With6H4-4-CF3With6H5S2-S0&x0200A;
1.723With6H4-4-CF3With6H5S4-S(O)0
1.724With6H4-4-CF3With6H5S3-S(O)0
1.725With6H4-4-CF3With6H5S2-S(O)0
1.726With6H4-4-CF3With6H5S4-C(O)0
1.727With6H4-4-CF3With6H5S4-C(O)1communication 3-Ar1
1.728With6H4-4-CF3With6H5S4-C(O)13-C(Oh)
1, 729mWith6H4-4-CF3With6H5S4-C(O)13-S(O2)

No. Ar1Ar2WQ1nQ2Physical. har-Ki
1.730With6H4-4-CF3With6H5S3-C(Oh)0
1.731With6H4-4-CF3With6H5S3-C(Oh)1nexus 4-Ar1
1.732With6H4-4-CF3With6H5S3-C(Oh)14-S(O2)
1.733With6H4-4-CF3With6H5S2-C(O)0
1.734With6H4-4-CF3With6H5S2-C(O)1communication 3-Ar1
1.735With6H4-4-CF3With6H5S2-C(O)13-C(Oh)
1.736With6H4-4-CF3With6H5S 2-C(O)13-S(O2)
1.737With6H4-4-CF3With6H4-2-ClAbout4-CH20
1.738With6H4-4-CF3With6H4-2-ClAbout3-CH20
1.739With6H4-4-CF3With6H4-2-ClAbout2-CH20
1.740With6H4-4-CF3With6H4-2-ClAbout4-och20
1.741With6H4-4-CF3With6H4-2-ClAbout3-och20
1.742With6H4-4-CF3With6H4-2-ClAbout2-och20
1.743With6H4-4-CF3With6H4-2-ClAbout4-S0
1.744With6H4-4-CF3With6H4-2-ClAbout3-S0
1.745With6H4-4-CF3With6H4-2-ClAbout2-S0
1.746With6H4-4-CF3With6H4-2-ClAbout4-S(O)0
1.747With6H4-4-CF3With6H4-2-ClAbout3-S(O)0
1.748With6H4-4-CF3With6H4-2-ClAbout2-S(O)0
1.749With6H4-4-CF3With6H4-2-ClAbout4-C(O)0
Of 1,750With6H4-4-CF3With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.751With6sub> 4-4-CF3With6H4-2-ClAbout4-C(O)13-C(Oh)
1.752With6H4-4-CF3With6H4-2-ClAbout4-C(O)13-S(O2)
1.753With6H4-4-CF3With6H4-2-ClAbout3-C(Oh)0
1.754With6H4-4-CF3With6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.755With6H4-4-CF3With6H4-2-ClAbout3-C(Oh)14-S(O2)
1.756With6H4-4-CF3With6H4-2-ClAbout2-C(O)0
1.757With6H4-4-CF3With6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.758With6H4-4-CF3With6the 4-2-ClAbout2-C(O)13-C(Oh)
1.759With6H4-4-CF3With6H4-2-ClAbout2-C(O)13-S(O2)
1.760With6H4-4-CF3With6H4-2-ClS4-CH20
1.761With6H4-4-CF3With6H4-2-ClS3-CH20
1.762With6H4-4-CF3With6H4-2-ClS2-CH20
1.763With6H4-4-CF3With6H4-2-ClS4-och20
1.764With6H4-4-CF3With6H4-2-ClS3-och20
1.765With6H4-4-CF3With6H4-2-ClS 2-och20
1.766With6H4-4-CF3With6H4-2-ClS4-S0
1.767With6H4-4-CF3With6H4-2-ClS3-S0
1.768With6H4-4-CF3With6H4-2-ClS2-S0
1.769With6H4-4-CF3With6H4-2-ClS4-S(O)0
1.770With6H4-4-CF3With6H4-2-ClS3-S(O)0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.771With6H4-4-CF3With6H4-2-ClS2-S(O)0
1.772With6H4-4-CF3With6H4-2-ClS4-C(O)0
1.773With6H4-4-CF3With6H4-2-ClS4-C(O)1communication 3-Ar1
1.774With6H4-4-CF3With6H4-2-ClS4-C(O)13-C(Oh)
1.775With6H4-4-CF3With6H4-2-ClS4-C(O)13-S(O2)
1.776With6H4-4-CF3With6H4-2-ClS3-C(Oh)0
1.777With6H4-4-CF3With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.778With6H4-4-CF3With6H4-2-ClS3-C(Oh)14-S(O2)
1.779sub> 6H4-4-CF3With6H4-2-ClS2-C(O)0
1.780With6H4-4-CF3With6H4-2-ClS2-C(O)1communication 3-Ar1
1.781With6H4-4-CF3With6H4-2-ClS2-C(O)13-C(Oh)
1.782With6H4-4-CF3With6H4-2-ClS2-C(O)13-S(O2)
1.783With6H4-4-CF3With6H4-4-CF3O4-CH20
1.784With6H4-4-CF3With6H4-4-CF3O3-CH20
1.785With6H4-4-CF3With6H4-4-CF3O2-CH20
1.786With6H4-4-C 3With6H4-4-CF3O4-och20
1.787With6H4-4-CF3With6H4-4-CF3O3-och20
1.788With6H4-4-CF3With6H4-4-CF3O2-och20
1.789With6H4-4-CF3With6H4-4-CF3O4-S0
1.790With6H4-4-CF3With6H4-4-CF3O3-S0
1.791With6H4-4-CF3With6H4-4-CF3O2-S0
1.792With6H4-4-CF3With6H4-4-CF3O4-S(O)0
1.793With6H4-4-CF3 With6H4-4-CF3O3-S(O)0
1.794With6H4-4-CF3With6H4-4-CF3O2-S(O)0
1.795With6H4-4-CF3With6H4-4-CF3O4-C(O)0
1.796With6H4-4-CF3With6H4-4-CF3O4-C(O)1communication 3-Ar1
1.797With6H4-4-CF3With6H4-4-CF3O4-C(O)13-C(Oh)
1.798With6H4-4-CF3With6H4-4-CF3O4-C(O)13-S(O2)
1.799With6H4-4-CF3With6H4-4-CF3O3-C(Oh)0
1.800With6H4-4-CF3 With6H4-4-CF3O3-C(Oh)1nexus 4-Ar1
1.801With6H4-4-CF3With6H4-4-CF3O3-C(Oh)14-S(O2)
1.802With6H4-4-CF3With6H4-4-CF3O2-C(O)0
1.803With6H4-4-CF3With6H4-4-CF3O2-C(O)1communication 3-Ar1
1.804With6H4-4-CF3With6H4-4-CF3O2-C(O)13-C(Oh)
1.805With6H4-4-CF3With6H4-4-CF3O2-C(O)13-S(O2)
1.806With6H4-4-CF3With6H4-4-CF3S4-CH20
1.807With6H4-4-CF 3With6H4-4-CF3S3-CH20
1.808With6H4-4-CF3With6H4-4-CF3S2-CH20
1.809With6H4-4-CF3With6H4-4-CF3S4-och20
1.810With6H4-4-CF3With6H4-4-CF3S3-och20
1.811With6H4-4-CF3With6H4-4-CF3S2-och20

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.812With6H4-4-CF3With6H4-4-CF3S4-S0
1.813With6H4-4-CF3With6H4-4-CF3S3-S0
1.814With6H4-4-CF3With6H4-4-CF3S2-S0
1.815With6H4-4-CF3With6H4-4-CF3S4-S(O)0
1.816With6H4-4-CF3With6H4-4-CF3S3-S(O)0
1.817With6H4-4-CF3With6H4-4-CF3S2-S(O)0
1.818With6H4-4-CF3With6H4-4-CF3S4-C(O)0
1.819With6H4-4-CF3With6H4-4-CF3S4-C(O)1communication 3-Ar1
1.820 6H4-4-CF3With6H4-4-CF3S4-C(O)13-C(Oh)
1.821With6H4-4-CF3With6H4-4-CF3S4-C(O)13-S(O2)
1.822With6H4-4-CF3With6H4-4-CF3S3-C(O)0
1.823With6H4-4-CF3With6H4-4-CF3S3-C(Oh)1nexus 4-Ar1
1.824With6H4-4-CF3With6H4-4-CF3S3-C(Oh)14-S(O2)
1.825With6H4-4-CF3With6H4-4-CF3S2-C(O)0
1.826With6H4-4-CF3With6H4-4-CF3S2-C(O)1communication 3-Ar1
1.827 With6H4-4-CF3With6H4-4-CF3S2-C(O)13-C(Oh)
1.828With6H4-4-CF3With6H4-4-CF3S2-C(O)13-S(O2)
1.829With6H4-4-OCF3With6H5About4-CH20
1.830With6H4-4-OCF3With6H5About3-CH30
1.831With6H4-4-OCF3With6H5About2-CH20
1.832With6H4-4-OCF3With6H5About4-och20
1.833With6H4-4-OCF3With6H5About3-och20
1.834With6H4-4-OCF3 With6H5About2-och20
1.835With6H4-4-OCF3With6H5About4-S0
1.836With6H4-4-OCF3With6H5About3-S0
1.837With6H4-4-OCF3With6H5About2-S0
1.838With6H4-4-OCF3With6H5About4-S(O)0
1.839With6H4-4-OCF3With6H5About3-S(O)0
1.840With6H4-4-OCF3With6H5About2-S(O)0
1.841With6H4-4-OCF3With6H5About4-C(O)0
1.842With6H4-4-OCF3With6H5About4-C(O)1communication 3-Ar1
1.843With6H4-4-OCF3With6H5About4-C(O)13-C(Oh)
1.844With6H4-4-OCF3With6H5About4-C(O)13-S(O2)
1.845With6H4-4-OCF3With6H5About3-C(Oh)0
1.846With6H4-4-OCF3With6H5About3-C(Oh)1nexus 4-Ar1
1.847With6H4-4-OCF3With6H5About3-C(Oh)14-S(O2)
1.848With6H4-4-OCF3With6H5About2-C(O)0
1.849 6H4-4-OCF3With6H5About2-C(O)1communication 3-Ar1
1.850With6H4-4-OCF3With6H5About2-C(O)13-C(Oh)
1.851With6H4-4-OCF3With6H5About2-C(O)13-S(O2)
1.852With6H4-4-OCF3With6H5S4-CH20

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.853With6H4-4-OCF3With6H5S3-CH20
1.854With6H4-4-OCF3With6H5S2-CH20
1.855With6H4-4-CF 3With6H5S4-och20
1.856With6H4-4-OCF3With6H5S3-och20
1.857With6H4-4-OCF3With6H5S2-och20
1.858With6H4-4-OCF3With6H5S4-S0
1.859With6H4-4-OCF3With6H5S3-S0
1.860With6H4-4-OCF3With6H5S2-S0
1.861With6H4-4-OCF3With6H5S4-S(O)0
1.862With6H4-4-OCF3With6H5S3-S(O) 0
1.863With6H4-4-OCF3With6H5S2-S(O)0
1.864With6H4-4-OCF3With6H5S4-C(O)0
1.865With6H4-4-OCF3With6H5S4-C(O)1communication 3-Ar1
1.866With6H4-4-OCF3With6H5S4-C(O)13-C(Oh)
1.867With6H4-4-OCF3With6H5S4-C(O)13-S(O2)
1.868With6H4-4-OCF3With6H5S3-C(Oh)0
1.869With6H4-4-OCF3With6H5S3-C(Oh)1nexus 4-Ar1
1.870 With6H4-4-OCF3With6H5S3-C(Oh)14-S(O2)
1.871With6H4-4-OCF3With6H5S2-C(O)0
1.872With6H4-4-OCF3With6H5S2-C(O)1communication 3-Ar1
1.873With6H4-4-OCF3With6H5S2-C(O)13-C(Oh)
1.874With6H4-4-OCF3With6H5S2-C(O)13-S(O2)
1.875With6H4-4-OCF3With6H4-2-ClAbout4-CH20
1.876With6H4-4-OCF3With6H4-2-ClAbout3-CH20
1.877With6H4-4-OCF3With6H -2-ClAbout2-CH20
1.878With6H4-4-OCF3With6H4-2-ClAbout4-och20
1.879With6H4-4-OCF3With6H4-2-ClAbout3-och20
1.880With6H4-4-OCF3With6H4-2-ClAbout2-och20
1.881With6H4-4-OCF3With6H4-2-ClAbout4-S0
1.882With6H4-4-OCF3With6H4-2-ClAbout3-S0
1.883With6H4-4-OCF3With6H4-2-ClAbout2-S0
1.884With6H4-4-OCF3With6H4-2-ClAbout4-S(O)0
1.885With6H4-4-OCF3With6H4-2-ClAbout3-S(O)0
1.886With6H4-4-OCF3With6H4-2-ClAbout2-S(O)0
1.887With6H4-4-OCF3With6H4-2-ClAbout4-C(O)0
1.888With6H4-4-OCF3With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.889With6H4-4-OCF3With6H4-2-ClAbout4-C(O)13-C(Oh)
1.890With6H4-4-OCF3With6H4-2-ClAbout4-C(O)13-S(O2)
1.891With6H4-4-OCF3With6H4-2-ClAbout3-C(Oh)0
1.892 With6H4-4-OCF3With6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.893With6H4-4-OCF3With6H4-2-ClAbout3-C(Oh)14-S(O2)

With6H4-2-Cl
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.894With6H4-4-OCF3With6H4-2-ClAbout2-C(O)0
1.895With6H4-4-OCF3With6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.896With6H4-4-OCF3With6H4-2-ClAbout2-C(O)13-C(Oh)
1.897With6H4-4-OCF3With6H4-2-ClAbout2-C(O)13-S(O2)
1.898the 6H4-4-OCF3With6H4-2-ClS4-CH20
1.899With6H4-4-OCF3With6H4-2-ClS3-CH30
1.900With6H4-4-OCF3With6H4-2-ClS2-CH20
1.901With6H4-4-OCF3With6H4-2-ClS4-och20
1.902With6H4-4-OCF3With6H4-2-ClS3-och30
1.903With6H4-4-OCF3With6H4-2-ClS2-och20
1.904With6H4-4-OCF3With6H4-2-ClS4-S0
1.905With6H4-4-OCF3S3-S0
1.906With6H4-4-OCF3With6H4-2-ClS2-S0
1.907With6H4-4-OCF3With6H4-2-ClS4-S(O)0
1.908With6H4-4-OCF3With6H4-2-ClS3-S(O)0
1.909With6H4-4-OCF3With6H4-2-ClS2-S(O)0
1.910With6H4-4-OCF3With6H4-2-ClS4-C(O)0
1.911With6H4-4-OCF3With6H4-2-ClS4-C(O)1communication 3-Ar1
1.912With6H4-4-OCF3With6H4-2-ClS4-C(O)1 3-C(Oh)
1.913With6H4-4-OCF3With6H4-2-ClS4-C(O)13-S(O2)
1.914With6H4-4-OCF3With6H4-2-ClS3-C(Oh)0
1.915With6H4-4-OCF3With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.916With6H4-4-OCF3With6H4-2-ClS3-C(Oh)14-S(O2)
1.917With6H4-4-OCF3With6H4-2-ClS2-C(O)0
1.918With6H4-4-OCF3With6H4-2-ClS2-C(O)1communication 3-Ar1
1.919With6H4-4-OCF3With6H4-2-ClS2-C(O)13-C(O)
Of 1,920With6H4-4-OCF3With6H4-2-ClS2-C(O)13-S(O2)
1.921With6H4-4-OCF3With6H4-4-CF3About4-CH20
1.922With6H4-4-OCF3With6H4-4-CF3About3-CH20
1.923With6H4-4-OCF3With6H4-4-CF3About2-CH20
1.924With6H4-4-OCF3With6H4-4-CF3About4-och20
1.925With6H4-4-OCF3With6H4-4-CF3About3-och20
1.926With6H4-4-OCF3With6H4-4-CF3About2-och20
1.927With6H4-4-OCF3With6H4-4-CF3About4-S0
1.928With6H4-4-OCF3With6H4-4-CF3About3-S0
1.929With6H4-4-OCF3With6H4-4-CF3About2-S0
1.930With6H4-4-OCF3With6H4-4-CF3About4-S(O)0
1.931With6H4-4-OCF3With6H4-4-CF3About3-S(O)0
1.932With6H4-4-OCF3With6H4-4-CF3About2-S(O)0
1.933With6H4-4-OCF3With6H4-4-CF3About4-C(O)0
With6H4-4-OCF3With6H4-4-CF3About4-C(O)1communication 3-Ar1

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.935With6H3-4-OCF3With6H4-4-CF3About4-C(O)13-C(Oh)
1.936With6H3-4-OCF3With6H4-4-CF3About4-C(O)13-S(O2)
1.937With6H4-4-OCF3With6H4-4-CF3About3-C(Oh)0
1.938With6H3-4-OCF3With6H4-4-CF3About3-C(Oh)1nexus 4-Ar1
1.939With6H3-4-OCF3With6H4-4-CF3About3-C(Oh)14-S(O2 )
1.940With6H4-4-OCF3With6H4-4-CF3About2-C(O)0
1.941With6H3-4-OCF3With6H4-4-CF3About2-C(O)1communication 3-Ar1
1.942With6H3-4-OCF3With6H4-4-CF3About2-C(O)13-C(Oh)
1.943With6H3-4-OCF3With6H4-4-CF3About2-C(O)13-S(O2)
1.944With6H4-4-OCF3With6H4-4-CF3S4-CH20
1.945With6H4-4-OCF3With6H4-4-CF3S3-CH20
1.946With6H4-4-OCF3With6H4-4-CF3S2-CH2 0
1.947With6H4-4-OCF3With6H4-4-CF3S4-och20
1.948With6H4-4-OCF3With6H4-4-CF3S3-och20
1.949With6H4-4-OCF3With6H4-4-CF3S2-och20
1.950With6H4-4-OCF3With6H4-4-CF3S4-S0
1.951With6H4-4-OCF3With6H4-4-CF3S3-S0
1.952With6H4-4-OCF3With6H4-4-CF3S2-S0
1.953With6H4-4-OCF3With6H4-4-CF3S4-S(O)0
1.954With6H4-4-OCF3With6H4-4-CF3S3-S(O)0
1.955With6H4-4-OCF3With6H4-4-CF3S2-S(O)0
1.956With6H4-4-OCF3With6H4-4-CF3S4-C(O)0
1.957With6H3-4-OCF3With6H4-4-CF3S4-C(O)1communication 3-Ar1
1.958With6H3-4-OCF3With6H4-4-CF3S4-C(O)13-C(Oh)
1.959With6H3-4-OCF3With6H4-4-CF3S4-C(O)13-S(O2)
1.960With6H4-4-OCF3With6H4-4-CF3S3-C(Oh)0
1.961With6H3-4-OCF3With6H4-4-CF3S3-C(Oh)1nexus 4-Ar1
1.962With6H3-4-OCF3With6H4-4-CF3S3-C(Oh)14-S(O2)
1.963With6H4-4-OCF3With6H4-4-CF3S2-C(O)0
1.964With6H3-4-OCF3With6H4-4-CF3S2-C(O)1communication 3-Ar1
1.965With6H3-4-OCF3With6H4-4-CF3S2-C(O)13-C(Oh)
1.966With6H3-4-OCF3With6H4-4-CF3S2-C(O)13-S(O2)
1.967With6H4-4-tert-C4H9With6H5About4-CH2 0
1.968With6H4-4-tert-C4H9With6H5About3-CH20
1.969With6H4-4-tert-C4H9With6H5About2-CH20
1.970With6H4-4-tert-C4H9With6H5About4-och20
1.971With6H4-4-tert-C4H9With6H5About3-och20
1.972With6H4-4-tert-C4H9With6H5About2-och20
1.973With6H4-4-tert-C4H9With6H5About4-S0
1.974With6H4-4-tert-C4H9With6H5 About3-S0
1.975With6H4-4-tert-C4H9With6H5About2-S0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.976With6H4-4-tert-C4H9With6H5About4-S(O)0
1.977With6H4-4-tert-C4H9With6H5About3-S(O)0
1.978With6H4-4-tert-C4H9With6H5About2-S(O)0
1.979With6H4-4-tert-C4H9With6H5About4-C(O)0
1.980With6H3-4-tert-C4H9 6H5About4-C(O)1communication 3-Ar1
1.981With6H3-4-tert-C4H9With6H5About4-C(O)13-C(Oh)
1.982With6H3-4-tert-C4H9With6H5About4-C(O)13-S(O2)
1.983With6H3-4-tert-C4H9With6H5About3-C(Oh)0
1.984With6H3-4-tert-C4H9With6H5About3-C(Oh)1nexus 4-Ar1
1.985With6H3-4-tert-C4H9With6H5About3-C(Oh)14-S(O2)
1.986With6H4-4-tert-C4H9With6H5About2-C(O)0
1.987With6H3-4-Trets 4H9With6H5About2-C(O)1communication 3-Ar1
1.988With6H3-4-tert-C4H9With6H5About2-C(O)13-C(O)
1.989With6H3-4-tert-C4H9With6H5About2-C(O)13-S(O2)
1.990With6H4-4-tert-C4H9With6H5S4-CH20
1.991With6H4-4-tert-C4H9With6H5S3-CH20
1.992With6H4-4-tert-C4H9With6H5S2-CH20
1.993With6H4-4-tert-C4H9With6H5S4-och20
1994 With6H4-4-tert-C4H9With6H5S3-och20
1.995With6H4-4-tert-C4H9With6H5S2-och20
1.996With6H4-4-tert-C4H9With6H5S4-S0
1.997With6H4-4-tert-C4H9With6H5S3-S0
1.998With6H4-4-tert-C4H9With6H5S2-S0
1.999With6H4-4-tert-C4H9With6H5S4-S(O)0
1.1000With6H4-4-tert-C4H9With6H5S3-S(O)0
1.1001 With6H4-4-tert-C4H9With6H5S2-S(O)0
1.1002With6H4-4-tert-C4H9With6H5S4-C(O)0
1.1003With6H3-4-tert-C4H9With6H5S4-C(O)1communication 3-Ar1
1.1004With6H3-4-tert-C4H9With6H5S4-C(O)13-C(O)
1.1005With6H3-4-tert-C4H9With6H5S4-C(O)13-S(O2)
1.1006With6H4-4-tert-C4H9With6H5S3-C(Oh)0
1.1007With6H3-4-tert-C4H9With6H5S3-C(Oh)1nexus 4-Ar1Ȋ
1.1008With6H3-4-tert-C4H9With6H5S3-C(Oh)14-S(O2)
1.1009With6H4-4-tert-C4H9With6H5S2-C(O)0
1.1010With6H3-4-tert-C4H9With6H5S2-C(O)1communication 3-Ar1
1.1011With6H3-4-tert-C4H9With6H5S2-C(O)13-C(O)
1.1012With6H3-4-tert-C4H9With6H5S2-C(O)13-S(O2)
1.1013With6H4-4-tert-C4H9With6H4-2-ClAbout4-CH20
1.1014With6H4-4-tert-C4H9With6H4-2-ClAbout3-CH2 0
1.1015With6H4-4-tert-C4H9With6H4-2-ClAbout2-CH20
1.1016With6H4-4-tert-C4H9With6H4-2-ClAbout4-och20

With6H4-2-Cl
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.1017With6H4-4-tert-C4H9With6H4-2-ClAbout3-och20
1.1018With6H4-4-tert-C4H9With6H4-2-ClAbout2-och20
1.1019With6H4-4-tert-C4H9With6H4-2-ClAbout4-S0
1.1020With6H4-4-tert-C4H9About3-S0
1.1021With6H4-4-tert-C4H9With6H4-2-ClAbout2-S0
1.1022With6H4-4-tert-C4H9With6H4-2-ClAbout4-S(O)0
1.1023With6H4-4-tert-C4H9With6H4-2-ClAbout3-S(O)0
1.1024With6H4-4-tert-C4H9With6H4-2-ClAbout2-S(O)0
1.1025With6H4-4-tert-C4H9With6H4-2-ClAbout4-C(O)0
1.1026With6H3-4-tert-C4H9With6H4-2-ClAbout4-C(O)1communication 3-Ar1
1.1027With6H3-4-tert-C 4H9With6H4-2-ClAbout4-C(O)13-C(Oh)
1.1028With6H3-4-tert-C4H9With6H4-2-ClAbout4-C(O)13-S(O2)
1.1029With6H3-4-tert-C4H9With6H4-2-ClAbout3-C(Oh)0
1.1030With6H3-4-tert-C4H9With6H4-2-ClAbout3-C(Oh)1nexus 4-Ar1
1.1031With6H3-4-tert-C4H9With6H4-2-ClAbout3-C(Oh)14-S(O2)
1.1032With6H4-4-tert-C4H9With6H4-2-ClAbout2-C(O)0
1.1033With6H3-4-tert-C4H9With6H4-2-ClAbout2-C(O)1communication 3-Ar1
1.1034With6H3-4-tert-C4H9With6H4-2-ClAbout2-C(O)13-C(Oh)
1.1035With6H3-4-tert-C4H9With6H4-2-ClAbout2-C(O)13-S(O2)
1.1036With6H4-4-tert-C4H9With6H4-2-ClS4-CH20
1.1037With6H4-4-tert-C4H9With6H4-2-ClS3-CH20
1.1038With6H4-4-tert-C4H9With6H4-2-ClS2-CH20
1.1039With6H4-4-tert-C4H9With6H4-2-ClS4-och20
1.1040With6H4-4-tert-C4H9With6H4-2-ClS3-sub> 20
1.1041With6H4-4-tert-C4H9With6H4-2-ClS2-och20
1.1042With6H4-4-tert-C4H9With6H4-2-ClS4-S0
1.1043With6H4-4-tert-C4H9With6H4-2-ClS3-S0
1.1044With6H4-4-tert-C4H9With6H4-2-ClS2-S0
1.1045With6H4-4-tert-C4H9With6H4-2-ClS4-S(O)0
1.1046With6H4-4-tert-C4H9With6H4-2-ClS3-S(O)0
1.1047With6H4-4-tert-C4H9With6H4-2-Cl S2-S(O)0
1.1048With6H4-4-tert-C4H9With6H4-2-ClS4-C(O)0
1.1049With6H3-4-tert-C4H9With6H4-2-ClS4-C(O)1communication 3-Ar1
1.1050With6H3-4-tert-C4H9With6H4-2-ClS4-C(O)13-C(Oh)
1.1051With6H3-4-tert-C4H9With6H4-2-ClS4-C(O)13-S(O2)
1.1052With6H3-4-tert-C4H9With6H4-2-ClS3-C(Oh)0
1.1053With6H3-4-tert-C4H9With6H4-2-ClS3-C(Oh)1nexus 4-Ar1
1.1054With6H3-4-tert-C4H9 With6H4-2-ClS3-C(Oh)14-S(O2)
1.1055With6H4-4-tert-C4H9With6H4-2-ClS2-C(O)0
1.1056With6H3-4-tert-C4H9With6H4-2-ClS2-C(O)1communication 3-Ar1
1.1057With6H3-4-tert-C4H9With6H4-2-ClS2-C(O)13-C(Oh)

td align="left"> With6H4-4-CF3
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.1058With6H3-4-tert-C4H9With6H4-4-CF3S2-C(O)13-S(O2)
1.1059With6H4-4-tert-C4H9With6H4-4-CF3About4-CH20
1.1060With6H4-4-tert-C4H9With6H4-4-CF3About3-CH20
1.1061With6H4-4-tert-C4H9With6H4-4-CF3About2-CH20
1.1062With6H4-4-tert-C4H9With6H4-4-CF3About4-och30
1.1063With6H4-4-tert-C4H9With6H4-4-CF3About3-och30
1.1064With6H4-4-tert-C4H9With6H4-4-CF3About2-och20
1.1065With6H4-4-tert-C4H9With6H4-4-CF3About4-S0
1.1066With6H4-4-tert-C4H9About3-S0
1.1067With6H4-4-tert-C4H9With6H4-4-CF3About2-S0
1.1068With6H4-4-tert-C4H9With6H4-4-CF3About4-S(O)0
1.1069With6H4-4-tert-C4H9With6H4-4-CF3About3-S(O)0
1.1070With6H4-4-tert-C4H9With6H4-4-CF3About2-S(O)0
1.1071With6H4-4-tert-C4H9With6H4-4-CF3About4-C(O)0
1.1072With6H3-4-tert-C4H9With6H4-4-CF3About4-C(O)1communication 3-Ar1
1.1073With6H3-4-tert-C4H9With6H4-4-CF3About4-C(O)13-C(Oh)
1.1074With6H3-4-tert-C4H9With6H4-4-CF3About4-C(O)13-S(O2)
1.1075With6H3-4-tert-C4H9With6H4-4-CF3About3-C(Oh)0
1.1076With6H3-4-tert-C4H9With6H4-4-CF3About3-C(Oh)1nexus 4-Ar1
1.1077With6H3-4-tert-C4H9With6H4-4-CF3About3-C(Oh)14-S(O2)
1.1078With6H4-4-tert-C4H9With6H4-4-CF3About2-C(O)0
1.1079With6H3-4-tert-C4H9With6H4-4-CF 3About2-C(O)1communication 3-Ar1
1.1080With6H3-4-tert-C4H9With6H4-4-CF3About2-C(O)13-C(Oh)
1.1081With6H3-4-tert-C4H9With6H4-4-CF3About2-C(O)13-S(O2)
1.1082With6H4-4-tert-C4H9With6H4-4-CF3S4-CH20
1.1083With6H4-4-tert-C4H9With6H4-4-CF3S3-CH20
1.1084With6H4-4-tert-C4H9With6H4-4-CF3S2-CH20
1.1085With6H4-4-tert-C4H9With6H4-4-CF3S4-och20
1.1086With6H4-4-tert-C4H9With6H4-4-CF3S3-och20
1.1087With6H4-4-tert-C4H9With6H4-4-CF3S2-och20
1.1088With6H4-4-tert-C4H9With6H4-4-CF3S4-S0
1.1089With6H4-4-tert-C4H9With6H4-4-CF3S3-S0
1.1090With6H4-4-tert-C4H9With6H4-4-CF3S2-S0
1.1091With6H4-4-tert-C4H9With6H4-4-CF3S4-S(O)0
1.1092With6H4-4-tert-C4H9With6H4-4-CF 3S3-S(O)0
1.1093With6H4-4-tert-C4H9With6H4-4-CF3S2-S(O)0
1.1094With6H4-4-tert-C4H9With6H4-4-CF3S4-C(O)0
1.1095With6H3-4-tert-C4H9With6H4-4-CF3S4-C(O)1communication 3-Ar1
1.1096With6H3-4-tert-C4H9With6H4-4-CF3S4-C(O)13-C(Oh)
1.1097With6H3-4-tert-C4H9With6H4-4-CF3S4-C(O)13-S(O2)
1.1098With6H4-4-tert-C4H9With6H4-4-CF3S3-C(O)0

1.1128
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.1099With6H3-4-tert-C4H9With6H4-2-CF3S3-C(Oh)1nexus 4-Ar1
1.1100With6H3-4-tert-C4H9With6H4-2-CF3S3-C(Oh)14-S(O2)
1.1101With6H3-4-tert-C4H9With6H4-2-CF3S2-C(O)0
1.1102With6H3-4-tert-C4H9With6H4-2-CF3S2-C(O)1communication 3-Ar1
1.1103With6H3-4-tert-C4H9With6H4-2-CF3S2-C(O)13-C(Oh)
1.1104With6H3-4-tert-C4H9With6H4-2-CF3S 2-C(O)13-S(O2)
1.11053-C5H4NWith6H5About4-CH20
1.11063-C5H4NWith6H5About3-CH20
1.11073-C5H4NWith6H5About2-CH20
1.11083-C5H4NWith6H5About4-och20
1.11093-C5H4NWith6H5About3-och30
1.11103-C5H4NWith6H5About2-och20
1.11113-C5H4NWith6H5About4-S0
1.11123-C5H4 With6H5About3-S0
1.11133-C5H4NWith6H5About2-S0
1.11143-C5H4NWith6H5About4-S(O)0
1.11153-C5H4NWith6H5About3-S(O)0
1.11163-C5H4NWith6H5About2-S(O)0
1.11173-C5H4NWith6H5About4-C(O)0
1.11183-C5H4NWith6H5About3-C(O)0
1.11193-C5H4NWith6H5About2-C(O)0
1.11203-C5H4N/td> With6H5S4-CH20
1.11213-C5H4NWith6H5S3-CH20
1.11223-C5H4NWith6H5S2-CH20
1.11233-C5H4NWith6H5S4-och20
1.11243-C5H4NWith6H5S3-och20
1.11253-C5H4NWith6H5S2-och20
1.11263-C5H4NWith6H5S4-S0
1.11273-C5H4NWith6H5S3-S0
3-C5H4NWith6H5S2-S0
1.11293-C5H4NWith6H5S4-S(O)0
1.11303-C5H4NWith6H5S3-S(O)0
1.11313-C5H4NWith6H5S2-S(O)0
1.11323-C5H4NWith6H5S4-C(O)0
1.11333-C5H4NWith6H5S3-C(Oh)0
1.11343-C5H4NWith6H5S2-C(O)0
1.11353-C5H4NWith6H4-2-ClAbout4-CH20
1.11363-C5H4NWith6H4-2-ClAbout3-CH20
1.11373-C5H4NWith6H4-2-ClAbout2-CH20
1.11383-C5H4NWith6H4-2-ClAbout4-och20
1.11393-C5H4NWith6H4-2-ClAbout3-och30

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.11403-C5H4NWith6H4-2-ClAbout2-och20
1.11413-C5H4NWith6H4-2-ClAbout4-S0
1.11423-C5H4N 6H4-2-ClAbout3-S0
1.11433-C5H4NWith6H4-2-ClAbout2-S0
1.11443-C5H4NWith6H4-2-ClAbout4-S(O)0
1.11453-C5H4NWith6H4-2-ClAbout3-S(O)0
1.11463-C5H4NWith6H4-2-ClAbout2-S(O)0
1.11473-C5H4NWith6H4-2-ClAbout4-C(O)0
1.11483-C5H4NWith6H4-2-ClAbout3-C(Oh)0
1.11493-C5H4NWith6H4-2-ClO2-C(O)0
1.11503-C5H 4NWith6H4-2-ClS4-CH20
1.11513-C5H4NWith6H4-2-ClS3-CH20
1.11523-C5H4NWith6H4-2-ClS2-CH20
1.11533-C5H4NWith6H4-2-ClS4-och20
1.11543-C5H4NWith6H4-2-ClS3-och20
1.11553-C5H4NWith6H4-2-ClS2-och20
1.11563-C5H4NWith6H4-2-ClS4-S0
1.11573-C5H4NWith6H4-2-ClS3-S0Ȁ
1.11583-C5H4NWith6H4-2-ClS2-S0
1.11593-C5H4NWith6H4-2-ClS4-S(O)0
1.11603-C5H4NWith6H4-2-ClS3-S(O)0
1.11613-C5H4NWith6H4-2-ClS2-S(O)0
1.11623-C5H4NWith6H4-2-ClS4-C(O)0
1.11633-C5H4NWith6H4-2-ClS3-C(Oh)0
1.11643-C5H4NWith6H4-2-ClS2-C(O)0
1.11653-C5H4NWith6H4-2-CF3About4-CH 20
1.11663-C5H4NWith6H4-2-CF3About3-CH20
1.11673-C5H4NWith6H4-2-CF3About2-CH20
1.11683-C5H4NWith6H4-2-CF3About4-och20
1.11693-C5H4NWith6H4-2-CF3About3-och20
1.11703-C5H4NWith6H4-2-CF3About2-och20
1.11713-C5H4NWith6H4-2-CF3About4-S0
1.11723-C5H4NWith6H4-2-CF3About3-S0#x0200A;
1.11733-C5H4NWith6H4-2-CF3About2-S0
1.11743-C5H4NWith6H4-2-CF3About4-S(O)0
1.11753-C5H4NWith6H4-2-CF3About3-S(O)0
1.11763-C5H4NWith6H4-2-CF3About2-S(O)0
1.11773-C5H4NWith6H4-2-CF3About4-C(O)0
1.11783-C5H4NWith6H4-2-CF3About3-C(Oh)0
1.11793-C5H4NWith6H4-2-CF3About2-C(O)0
1.11803-C5H4NWith6H4-2-CFsub> 3S4-CH20

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.11813-C5H4NWith6H4-2-CF3S3-CH20
1.11823-C5H4NWith6H4-2-CF3S2-CH20
1.11833-C5H4NWith6H4-2-CF3S4-och20
1.11843-C5H4NWith6H4-2-CF3S3-och20
1.11853-C5H4NWith6H4-2-CF3S2-och20
1.11863-C5H4NWith6H4-2-CF3 S4-S0
1.11873-C5H4NWith6H4-2-CF3S3-S0
1.11883-C5H4NWith6H4-2-CF3S2-S0
1.11893-C5H4NWith6H4-2-CF3S4-S(O)0
1.11903-C5H4NWith6H4-2-CF3S3-S(O)0
1.11913-C5H4NWith6H4-2-CF3S2-S(O)0
1.11923-C5H4NWith6H4-2-CF3S4-C(O)0
1.11933-C5H4NWith6H4-2-CF3S3-C(Oh)0
3-C5H4NWith6H4-2-CF3S2-C(O)0
1.11952-C4H3SWith6H5O4-CH20
1.11962-C4H3SWith6H5O3-CH20
1.11972-C4H3SWith6H5O2-CH20
1.11982-C4H3SWith6H5O4-och20
1.11992-C4H3SWith6H5O3-och20
1.12002-C4H3SWith6H5O2-och20
1.12012-C4H3SWith6H5O4-S 0
1.12022-C4H3SWith6H5O3-S0
1.12032-C4H3SWith6H5O2-S0
1.12042-C4H3SWith6H5O4-S(O)0
1.12052-C4H3SWith6H5O3-S(O)0
1.12062-C4H3SWith6H5O2-S(O)0
1.12072-C4H3SWith6H5O4-C(O)0
1.12082-C4H3SWith6H5O3-C(Oh)0
1.12092-C4H3SWith6H5O2-C(O) 0
1.12102-C4H3SWith6H5S4-CH20
1.12112-C4H3SWith6H5S3-CH20
1.12122-C4H3SWith6H5S2-CH20
1.12132-C4H3SWith6H5S4-och20
1.12142-C4H3SWith6H5S3-och20
1.12152-C4H3SWith6H5S2-och20
1.12162-C4H3SWith6H5S4-S0
1.12172-C4H3SWith H5S3-S0
1.12182-C4H3SWith6H5S2-S0
1.12192-C4H3SWith6H5S4-S(O)0
1.12202-C4H3SWith6H5S3-S(O)0
1.12212-C4H3SWith6H5S2-S(O)0

O
No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.12222-C4H3SWith6H5S4-C(O)0
1.12232-C4H3SWith6H5S3-C(O)0
1.1224 2-C4H3SWith6H5S2-C(O)0
1.12252-C4H3SWith6H4-2-ClO4-CH20
1.12262-C4H3SWith6H4-2-ClO3-CH20
1.12272-C4H3SWith6H4-2-ClO2-CH20
1.12282-C4H3SWith6H4-2-ClO4-och20
1.12292-C4H3SWith6H4-2-ClO3-och20
1.12302-C4H3SWith6H4-2-ClO2-och20
1.12312-C4H3SWith6H4-2-ClO4- 0
1.12322-C4H3SWith6H4-2-ClO3-S0
1.12332-C4H3SWith6H4-2-ClO2-S0
1.12342-C4H3SWith6H4-2-ClO4-S(O)0
1.12352-C4H3SWith6H4-2-ClO3-S(O)0
1.12362-C4H3SWith6H4-2-ClO2-S(O)0
1.12372-C4H3SWith6H4-2-ClO4-C(O)0
1.12382-C4H3SWith6H4-2-ClO3-C(Oh)0
1.12392-C4H3SWith6H4-2-Cl2-C(O)0
1.12402-C4H3SWith6H4-2-ClS4-CH20
1.12412-C4H3SWith6H4-2-ClS3-CH20
1.12422-C4H3SWith6H4-2-ClS2-CH20
1.12432-C4H3SWith6H4-2-ClS4-och20
1.12442-C4H3SWith6H4-2-ClS3-och20
1.12452-C4H3SWith6H4-2-ClS2-och20
1.12462-C4H3SWith6H4-2-ClS4-S0
1.1247/td> 2-C4H3SWith6H4-2-ClS3-S0
1.12482-C4H3SWith6H4-2-ClS2-S0
1.12492-C4H3SWith6H4-2-ClS4-S(O)0
1.12502-C4H3SWith6H4-2-ClS3-S(O)0
1.12512-C4H3SWith6H4-2-ClS2-S(O)0
1.12522-C4H3SWith6H4-2-ClS4-C(O)0
1.12532-C4H3SWith6H4-2-ClS3-C(Oh)0
1.12542-C4H3SWith6H4-2-ClS2-C(O)0ÈA;
1.12552-C4H3SWith6H4-2-CF3O4-CH20
1.12562-C4H3SWith6H4-2-CF3O3-CH20
1.12572-C4H3SWith6H4-2-CF3O2-CH20
1.12582-C4H3SWith6H4-2-CF3O4-och20
1.12592-C4H3SWith6H4-2-CF3O3-och20
1.12602-C4H3SWith6H4-2-CF3O2-och20
1.12612-C4H3SWith6H4-2-CF3O4-S0
1.12622C 4H3SWith6H4-2-CF3O3-S0

No.Ar1Ar2WQ1nQ2Physical. har-Ki
1.12632-C4H3SWith6H4-2-CF3O2-S0
1.12642-C4H3SWith6H4-2-CF3About4-S(O)0
1.12652-C4H3SWith6H4-2-CF3O3-S(O)0
1.12662-C4H3SWith6H4-2-CF3O2-S(O)0
1.12672-C4N 3SWith6H4-2-CF3O4-C(O)0
1.12682-C4H3SWith6H4-2-CF3O3-C(Oh)0
1.12692-C4H3SWith6H4-2-CF3O2-C(O)0
1.12702-C4H3SWith6H4-2-CF3S4-CH20
1.12712-C4H3SWith6H4-2-CF3S3-CH20
1.12722-C4H3SWith6H4-2-CF3S2-CH20
1.12732-sub> 4H3SWith6H4-2-CF3S4-och20
1.12742-C4H3SWith6H4-2-CF3S3-och20
1.12752-C4H3SWith6H4-2-CF3S2-och20
1.12762-C4H3SWith6H4-2-CF3S4-S0
1.12772-C4H3SWith6H4-2-CF3S3-S0
1.12782-C4H3SWith6H4-2-CF3S2-S0
1.1279 2-C4H3SWith6H4-2-CF3S4-S(O)0
1.12802-C4H3SWith6H4-2-CF3S3-S(O)0
1.12812-C4H3SWith6H4-2-CF3S2-S(O)0
1.12822-C4H3SWith6H4-2-CF3S4-C(O)0
1.12832-C4H3SWith6H4-2-CF3S3-C(Oh)0
1.12842-C4H3SWith6H4-2-CF3S2-C(O)0
Table 2

No.Q1Ar2Physical. har-Ki
2.14-CH(OH)With6H4-2-CF3tpl.72°
2.24-(CH3)(IT)With6H4-2-CF3tpl.108-110°
2.34-C(NOCH3)With6H4-2-CF3tpl.61°
2.44-C(O)With6H3-2-Cl-5-CH3tpl.148-150°
2.54-C(O)With6H3-2,5-Cl2tpl.160-162°
2.64-C(O)With6H2-2-Br-4,5-F2tpl.69-71°

Biological examples

1. Experience in vivo in clawed Mongolian gerbils (Meriones unguiculatus) against nematode Trichostrongylus colubriformis and At contortus by oral administration of the active substance.

Clawed Mongo is skih gerbils aged six to eight weeks were infected by artificial feeding larvae .colubriformis and .contortus third stages in the amount of approximately 2000 individuals of each insect. After 6 days after infection of gerbils subjected to mild anesthesia with N2O and oral was administered test compounds, dissolved in a mixture of 2 parts DMSO and 1 part of polyethylene glycol (PEG 300), in doses of 100, 32 and 10-0,1 mg/kg On the 9th day (3 days after administration of the test compounds to which the majority still present larvae .contortus reached the 4th age, and the majority of larvae .colubriformis reached immature adult stage, gerbils were killed for counting the number of worms. The effectiveness of the test compounds was calculated as the percentage decrease in the number of worms in each gerbils compared with the geometric mean number of worms in 8 infected and not treated with the test compounds gerbils.

The results of this experience, it was found that the compounds of formula I, above all from table 1, provide a significant reduction in the number of nematodes in infected animals. Thus, in particular, when using compounds 1.59 and 1.105 even when administered at doses of 32 mg/kg animal infections by helminths Trichostrongylus reduced by 100%.

Insecticidal and/or acaricidal action of the compounds of formula I on animals and plants can be checked in accordance with the experiments discussed below.

2. Insecticidal intestinal action poisonous substance p is otiv Spodoptera littoralis.

Potted cotton plants at the stage 5 leaf individually sprayed with a solution of test compound in acetone/water containing the test compound at a concentration of 1.3, 12.5 or 50 part./million Then plants after drying put on them by spraying coating infect Spodoptera littoralis colonies of about 30 larvae each (under age L1). Each used in the experiment as a pest infect and each test compound is treated in two plants. The experience is carried out at a temperature of about 24°C and 60%relative humidity. The number of dead pests and their larvae, as well as caused to plants harm from eating them pests define the intermediate stages after 24 and 48 h and finally at 72 hours

3. The phyto-toxic effect against acarid.

Experience sensitive to organophosphorus compounds Tetranychus urticae

Primary leaves of bean plants (Phaseolus vulgaris) for 16 h before the start of the experiment cover obtained by mass cultivation of a piece of leaf infected with T. urticae. After removal of this piece of sheet plants infected ticks all age stages, liberally sprayed until drops of the solution containing the test compound at a concentration of 0.2, and 0.4 or 1.6 to frequent./million during the experience the temperature in the greenhouse support h is about 25° C. After 7 days estimate the percentage reduction in the population, determining under a microscope the number of motile mites (adults and nymphs) and eggs.

4. Action against larvae of Lucilia sericata age L1.

1 ml of a water suspension of the tested active substance is mixed at a temperature of about 50°With 3 ml of a special environment for growing larvae, receiving the homogenate containing the active substance 250 or 125 ppm million Experience performed using approximately 30 larvae of Lucilia (stage L1) based on each in vitro test model. The mortality of the pests determined after 4 days.

5. Acaricidal activity against Boophilus microplus (Biarra strain).

To the plate PVC horizontally attach a piece of tape such length that it can be in one row to paste their backs 10 completely sucked the blood females of the tick Boophilus microplus (Biarra strain). Then in the body of each tick using the injection needle is injected 1 µl of fluid. This fluid is a mixture of polyethylene glycol and acetone in the ratio 1:1 and contains a certain amount of dissolved active substance, component 1, of 0.1 or 0.01 μg per tick. The clamp control group inject without active substance. After treatment, the ticks are placed in hectare, where they are under normal conditions at a temperature of about 28°C and 80%relative humidity up to egg laying until hatching of larvae from eggs of mites in the control group. The effectiveness of the test compounds is determined by the indicator IR90i.e. determine the dose of the active substance at which 9 out of 10 female ticks (corresponds to 90%) lay eggs that remain unfertilized even after 30 days.

6. Assessment of the effectiveness of in vitro experience sucked the blood of the female Boophilus microplus (BIARRA).

Sucked the blood of the female mite resistant to organophosphorus compounds of BIARRA strain attach 4 groups of 10 animals each to the sticky tape and 1 h served with a cotton ball soaked in the emulsion or suspension of the test compounds at a concentration of 500, 125, 31 and 8 ppm million respectively. The effectiveness of the test compounds are assessed in 28 days mortality of mites, the deposition of their eggs and hatching larvae from eggs.

A measure of the activity of the test compounds is the number of females who

- die shortly before laying eggs,

- survive for some period of time, not laying eggs,

- lay eggs that do not form embryos,

- lay eggs, which are formed embryos, but are not valuble the tsya larvae, and

- lay eggs, which are formed embryos and of which usually on 26-27 day hatch into larvae.

7. Contact action against Aphis craccivora.

The pea seedlings infected with epidemi all stages of development, are sprayed with a solution of the active substance obtained from mulgirigala concentrate containing the active ingredient, depending on the specific requirements in concentrations of 50, 25 or 12.5 ppm million In evaluating the effectiveness of the tested compounds more than 80% of the total number of afid should after 3 days either to die or to be showered with plants. The preparation is effective only if it has a similar level of activity.

8. Larvicide activity against Aedes aegypti.

On the surface of the water, bathed in a volume of 150 ml in the appropriate capacity, pipette add 0.1%solution of active substance in acetone in an amount sufficient to achieve a desired concentration of active substance in the obtained solution, equal to 10, or 3,3 1,6 frequent./million After evaporation of the acetone in the tank is placed approximately 30-40 larvae of Aedes 3 days old. 1, 2 and 5 days to determine the mortality of larvae.

9. Assessment of the effectiveness of in vivo experience against adult fleas Ctenocephalides felis in domestic cats when administered orally they tested compounds.

Domestic cats before and and after their feeding orally administered the test substance in gelatin capsules at a dose ranging from 0.5 to 20 mg/kg On the 1st, 3rd, 7th and 10th day after administration of the tested compounds each cat depending on the space on her previous colony of fleas infect 100 fleas (approximately 50 male and about 50 females). The effectiveness of the test compounds (reducing the number of fleas in percentage terms) estimate the number of live fleas that are found after 10 minutes of combing through one day after the cat each new colony of fleas, and the efficiency in % is calculated by subtracting the number of live fleas in treated animals of the arithmetic mean number of live fleas control animals, by dividing the obtained difference by the arithmetic mean number of live fleas control animals and by multiplying the obtained private 100.

Affected fleas found in cells that contain cats, and combed their hair, harvested, placed in the incubator, which supports the temperature of 28°C at 70%relative humidity and 24 hours to determine the survival/mortality of fleas. If the majority of affected fleas are killed, the test compound is classified as having adulticidal effect on fleas, and if a majority of the affected fleas survive, then the test compound is classified as having a "knockdown"-AK is ewnetu (i.e. test the connection for some time disrupts the activity of fleas, but does not cause complete loss).

10. Assessment of the effectiveness of in vivo experience against adult fleas Ctenocephalides felis in domestic cats using samarasekera product for spot treatment.

Domestic cats are treated samarasekera drug for spot treatment at a dose ranging from 0.5 to 10 mg/kg On the 1st, 3rd, 7th and 10th day after processing each cat depending on the space on her previous colony of fleas infect 100 fleas (approximately 50 male and about 50 females).

The effectiveness of the test compounds (reducing the number of fleas in percentage terms) estimate the number of live fleas that are found after 10 minutes of combing through one day after the cat each new colony of fleas, and the efficiency in % is calculated by subtracting the number of live fleas in treated animals of the arithmetic mean number of live fleas control animals, by dividing the obtained difference by the arithmetic mean number of live fleas control animals and by multiplying the obtained private 100.

Affected fleas found in cells that contain cats, and combed their hair, collected, placed in an incubator, in which the support temperature is 28 ru° C at 70%relative humidity and 24 hours to determine the survival/mortality of fleas. If the majority of affected fleas are killed, the test compound is classified as having adulticidal effect on fleas, and if a majority of the affected fleas survive, then the test compound is classified as having a "knockdown activity (i.e. test the connection for some time disrupts the activity of fleas, but does not cause complete loss).

11. Assessment of the effectiveness of in vitro experience on the nymphs of Amblyomma hebraeum.

About 5 hungry nymphs placed in the tube of polystyrene containing 2 ml of solution, suspension or emulsion of the test compound.

After diving nymphs for 10 min in the test solution, suspension or emulsion and double shaking on a vibratory mixer each time for 10 test tubes sealed tight wad of cotton wool and turned bottom up. After you have absorbed all the liquid with a cotton ball about half push all still in the inverted position the tube, squeezing the way of a cotton ball a greater quantity soaked them fluid flowing in installed under the test tube and Petri dish.

After this the tubes to evaluate the results of experience incubated at room temperature in the premises with natural lighting. Across the 14 days of the experimental test tubes immersed in a beaker of boiling water. If, in response to such heat mites begin to move, that this effect indicates no acaricidal action of the tested compounds in the studied concentration, and if the mites remain stationary, which testifies to their death, then the test compound is classified as having acaricidal effect in the studied concentration. All compounds examined in the concentration range from 0.1 to 100 ppm million

12. Action against Dermanyssus sallinae.

2-3 ml of a solution containing the active substance at a concentration of 10 ppm million, and about 200 species of mite (Dermanyssus gallinae) in various stages of development are placed in the open top glass container. After that, the container is closed with a wad of cotton wool, shaken for 10 min until complete wetting solution all ticks and then briefly turned upside down, so that the remaining solution can be absorbed into the cotton. After 3 days, determine the mortality of mites, counting the number of dead individuals and Express the result as a percentage.

13. Activity against Musca domestica.

The sugar cube is treated with a solution of the tested compound in such a way that its concentration in the Sahara after drying over night was 250 ppm million Processed in this way the sugar cube is placed in an aluminum Cup with a damp cotton wool and 10 is taslimi species Musca domestica resistant to organophosphorus compounds of strain, covered laboratory glass, and incubated at 25°C. the Mortality of the flies determine in 24 hours

1. The compounds of formula

in which Ar1and Ar2independently from each other represent unsubstituted phenyl or one or mnogozalny phenyl, the substituents of which may be independent from each other values and selected from the group comprising halogen, C1-C6alkyl or halo-C1-C6alkyl;

Q1denotes co2or C(O);

Q2denotes a direct bond or C(O);

R3denotes hydrogen,

R4, R5, R6independently of one another denote hydrogen or C1-C6alkyl,

W represents O or S,

and denotes 1, 2, 3 or 4;

b represents 0, and

n denotes 0 or 1.

2. The compounds of formula I according to claim 1, in which Q1indicates(On).

3. The compounds of formula I according to claim 1, in which W represents O.

4. The compounds of formula I according to claim 1, where and denotes 1, 2 or 4.

5. The compounds of formula I according to claim 1, where and denotes 1 or 4.

6. The compounds of formula I according to claim 1, in which and means 1.

7. The compounds of formula I according to claim 1, in which n denotes 0.

8. The compound of formula I according to claim 1, which represents a 4-benzoyl-N-[1-cyano-1-methyl-2-(2-triptoreline)ethyl]benzamide./p>

9. The method of obtaining compounds of formula I, respectively in free form or in salt form, according to claim 1 or 2, consisting in the fact that the compound of the formula

in which R3, R4, R5, R6, W, Ar2, a and b are specified for formula I values are cooperation, optionally in the presence of a basic catalyst, with a compound of the formula

in which Ar1, Q1, Q2and n have the above for formula I value, and X denotes a leaving group.

10. Composition for combating nematodes which comprises as active ingredient at least one compound of formula I according to claim 1 or 2, as well as the media and/or dispersing agents.

11. The use of compounds of the formula I according to claim 1 for combating nematodes.

12. The way to combat parasites, is the impact on nematodes effective amount of at least one of the compounds of formula I according to claim 1.

13. The use of the compounds of formula I according to claim 1 in a method of combating nematodes in warm-blooded animals.

14. The use of the compounds of formula I according to claim 1 for the preparation of pharmaceutical compositions for combating nematodes in warm-blooded animals.



 

Same patents:

FIELD: organic synthesis.

SUBSTANCE: invention provides compounds of general formula I:

, where R1 represents -CO-Ra, -SO2-Rb, or aryl optionally substituted by lower alkoxy, wherein Ra represents cycloalkyl, cycloalkyl(lower)alkyl, cycloalkyloxy, aryl, aryloxy, aryl(lower)alkyl, aryl(lower)alkoxy, aryloxy(lower)alkyl, aryl-S-(lower)alkyl, aryl(lower)alkenyl, provided that aryl group can be optionally substituted by halogen, lower alkyl, hydroxy, nitro, cyano, lower alkoxy, phenyl, CF3, cyano(lower)alkyl, lower alkyl-C(O)NH, lower alkyl-CO, and lower alkyl-S; heteroaryl, heteroaryl(lower)alkyl, or heteroaryl(lower)alkoxy, provided that heteroaryl group is 5- or 6-membered ring or bicyclic aromatic group constituted by two 5- or 6-membered rings including 1-3 heteroatoms selected from oxygen, nitrogen, and sulfur and that heteroaryl group can be optionally substituted by lower alkoxy; Rb represents aryl, aryl(lower)alkyl, or heteroaryl, aryl group optionally substituted by halogen, cyano, or lower alkyl-C(O)NH; R2 and R3 represent hydrogen atoms; R4 representshydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, cycloalkyl, benzodioxyl, or aryl optionally substituted by lower alkyl, halogen, lower alkoxy, hydroxy, or (lower)alkyl-C(O)O; n is 1 or 2; and pharmaceutically acceptable salts thereof and/or pharmaceutically acceptable esters thereof. Invention also provides a pharmaceutical composition exhibiting inhibitory activity with regard to cysteine proteases of the cathepsin family, which composition comprises compound of formula I, pharmaceutically acceptable recipient, and/or adjuvant.

EFFECT: increased choice of cysteine protease inhibitors.

34 cl, 1 tbl, 13 ex

FIELD: veterinary, in particular veterinary parasitology.

SUBSTANCE: claimed pharmaceutical preparation contains (mass %): cypermethin 2.25-2.75; dimethylsulfoxide 10.0-30.0; polyethylene glycol-400-10.0-40.0; and balance: isopropanol. Said preparation has no topical irritant and allergic action; teratogenic and toxic action, doesn't inhibit antitoxic liver function, and doesn't change hematology and biochemical characteristics in cows.

EFFECT: new drug for treatment and prophylaxis of hypodermatosis of increased effectiveness.

2 ex

FIELD: veterinary, in particular formulation for controlling of mammalian skin pests.

SUBSTANCE: claimed formulation contains (mass %): fipronil 0.3-5; methopren up to 1 %; benzylbenzoate 5-40 and balance: alcohol solvent. Formulation of present invention is useful in agriculture and treatment of domestic and wild animals, as well as treatment of apartments.

EFFECT: effective formulation for controlling of mammalian skin pests with prolonged storage time.

4 cl, 5 ex

FIELD: veterinary, in particular formulation for controlling of mammalian skin pests.

SUBSTANCE: claimed formulation contains (mass %): fipronil 0.3-5; methopren up to 1 %; benzylbenzoate 5-40 and balance: alcohol solvent. Formulation of present invention is useful in agriculture and treatment of domestic and wild animals, as well as treatment of apartments.

EFFECT: effective formulation for controlling of mammalian skin pests with prolonged storage time.

4 cl, 5 ex

FIELD: medicine, in particular agent for treatment of hepatitis, toxoplasmosis, cytomegaloviral infection and influenza.

SUBSTANCE: claimed agent contains physiological saline for intravenous administration, comprising hydrogen peroxide, 0.2 % riboxine solution and decoction of liquorice roots in specific ratio.

EFFECT: non-toxic and effective agent for treatment of abovementioned diseases.

7 ex

FIELD: medicine, medicinal parasitology.

SUBSTANCE: method involves administration of solution containing 20-30 g of sodium hydrocarbonate in 800 ml of water with temperature 38-42° by rectal route followed by its time hold in intestine for 30 min. before and after this procedure method involves prescription a cleansing enema. Method provides intensifying expulsion of helminthes and exclusion of toxic effect of therapy carried out.

EFFECT: improved expulsion method of helminthes.

3 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition used in treatment of tuberculosis by preparations based on protionamide. The pharmaceutical composition consists of a core comprising protionamide as an active substance, microcrystalline cellulose, calcium stearate, cellulose derivative, special additives, and envelope comprising cellulose derivative, dye and accessory substance. Hydroxypropylcellulose is used as a derivative of cellulose, and calcium hydrophosphate dihydrate and croscarmelose sodium are used as special additives, and copolymer of vinylpyrrolidone with vinyl acetate taken in the ratio = 6:4 is used as accessory substance in envelope. Invention provides enhancing stability at storage and rapid release of active substance in digestive tract.

EFFECT: improved and valuable pharmaceutical properties of pharmaceutical composition.

2 tbl

FIELD: veterinary and medicinal helminthology.

SUBSTANCE: the present innovation deals with introducing cell culture out of Echinococcus multiocularis protoscoleces mixed with ribotan in efficient quantities, thrice subcutaneously at 10-d-long interval.

EFFECT: higher efficiency of prophylaxis.

2 ex, 3 tbl

FIELD: organic chemistry, pesticides.

SUBSTANCE: claimed composition represents mixture of carvacrol and thymol compounds with salt of transition metal, namely zinc, wherein carvacrol and thymol compound/zinc ratio is from 60:40 to 65:35. Also described is pesticide composition containing mixture of carvacrol and thymol compounds with salt of transition metal, namely zinc, and at least one carrier, wherein weight ratio of carvacrol to thymol is 10:1. Claimed method for parasite controlling includes step of composition blending with carrier and application thereof onto target area.

EFFECT: composition for pest controlling and prevention of contamination with pests such as insect, mite, fungi or parasites.

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with preventing and treating diseases caused by animal endoparasites. Anti-parasitic preparation contains closantel or its sodium salt dissolved in the main solvent as polyethylene glycol, propylene glycol, triethylene glycol or their mixtures, the suggested preparation contains, also, novocain (or lidocain, or anaesthesin), ethanol and/or isopropyl alcohol, polyvinyl pyrrolidone, benzyl alcohol and water at certain ratio of components. The innovation provides high efficiency of anti-parasitic action at no pain and inflammatory reaction in animals both at intramuscular and subcutaneous types of injection, moreover, decreased milk yields in cows haven't been observed.

EFFECT: higher efficiency.

1 cl, 96 ex

FIELD: veterinary science.

SUBSTANCE: the suggested preparation contains Trichlorfon and 30%-ethanol at the following ratio of components, weight%: Trichlorfon 3.5-3.7 and 30%-ethanol or 3%-boric acid solution in 30%-ethanol - up to 100. Application of this innovation enables to shorten therapy terms and improves therapeutic effect.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to new pharmaceutical compositions comprising bicyclic compound of the formula (I): wherein A means -COOH or their functional derivative; X1 and X2 mean hydrogen or halogen atom; V1 and V2 mean carbon atoms; W1 and W2 mean groups and wherein R4 and R mean hydrogen atom, hydroxy-group; Z means carbon, oxygen, sulfur or nitrogen atom; R1 means saturated or unsaturated bivalent (C1-C10)-aliphatic hydrocarbon residue; R2 means saturated or unsaturated (C1-C10)-aliphatic hydrocarbon residue; R3 means hydrogen atom and glyceride. Also, invention relates to a method for stabilizing compositions and novel bicyclic compounds. Invention provides enhancing stability of pharmaceutical composition based on its dissolving in glyceride.

EFFECT: improved and valuable properties of compositions, improved stabilization of compositions.

42 cl, 8 tbl, 8 ex

FIELD: organic chemistry, medicine, pharmacology.

SUBSTANCE: invention relates to new derivatives of carbamic acid esters of the general formula (I):

and their pharmaceutically acceptable salts eliciting activity with respect to metabotropic glutamate receptors mGlu of group I that can be used for treatment of acute and/or chronic neurological disorders. In the general formula (I) R1 means hydrogen atom or (C1-C7)-alkyl; R2 and R2' mean independently of one another hydrogen atom, (C1-C7)-alkyl, (C1-C7)-alkoxy-group, halogen atom or trifluoromethyl; X means oxygen (O), sulfur (S) atom or two hydrogen atoms not forming a bridge; A1/A2 mean independently of one another phenyl or 6-membered heterocycle comprising 1 or 2 nitrogen atom; B represents group of the formula:

wherein R3 means (C1-C7)-alkyl and others; Y means -O-, -S- or a bond; Z means -O- or -S-; or B means 5-membered heterocyclic group of formulae: (a) , (b) , (c) or (d) . Also, invention relates to methods for preparing compounds and to a medicinal agent based on thereof.

EFFECT: improved preparing methods, valuable medicinal properties of compounds.

22 cl, 1 tbl, 2 sch, 78 ex

The invention relates to medicine, namely to section narcology, and can be used for the treatment of tobacco

The invention relates to new derivatives aminomethylpropanol acid formula 1

< / BR>
where Z represents (CH2)n, O or S; n is 0, 1 or 2; X represents 1-3 substituent, independently selected from hydrogen, halogen, (C1-6)alkyloxy,(C3-6)cycloalkane, (C6-12)aryloxy, (C6-12)aryl, teinila, CN, СООR6and (C1-4)alkyl, optionally substituted with halogen, or 2 substituent in adjacent positions together represent a condensed (C5-6)aryl group, or O-(CH2)m-O, where m is 1 or 2; Y is 1-3 selected from hydrogen, halogen, (C1-4)alkyloxy and (C1-4)alkyl, optionally substituted with halogen; R1represents COOR7; R2and R6are (C1-4)alkyl; R3, R4and R5independently represent hydrogen; R7, R8and R9independently represent hydrogen or (C1-4)alkyl; or pharmaceutically acceptable salts, and pharmaceutical compositions on their basis, with effect on the Central nervous system

The invention relates to new N-phenylamine and N-pyridylamine derivative of the formula I

< / BR>
in which X denotes O or S;

R1and R2which may be identical or different, denote hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl or R1and R2together with the carbon atom to which they are attached, form a (C3-C8)cycloalkyl;

R3means (C6-C12)aryl, optionally substituted by one or more radicals Y, which may be the same or different;

Y represents halogen;

R4and R5represent hydrogen;

Ar denotes one of the following groups or WITH:

< / BR>
T represents hydrogen or (C1-C6)alkyl;

T3and T4which may be identical or different, denote (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)allylthiourea;

R6and R7each denotes hydrogen or R6and R7together represent a bond;

Z denotes either (I) the divalent group-CHR9- in which the R11-, in which R10and R11together they form a bond that Z represents the group-CH=CH-, or R10and R11that may be the same or different, have the meanings indicated above for R9or (III) a divalent group-CHR12-CHR13-CH2-, in which R12and R13together they form a bond, Z represents-CH=CH-CH2-, or R12and R13that may be the same or different, have the meanings indicated above for R9,

as well as their additive salts with pharmaceutically acceptable acids or bases, and method of production thereof, pharmaceutical compositions and drug manifesting gipolipedimecescoe and antiatherosclerotic action based on them

The invention relates to new derivatives (tetrahydro-1-oxido-thiopyran-4-yl)phenyloxazolidine General formula I, in which R1means methyl, ethyl, cyclopropyl, dichloromethyl, R2and R3are identical or different and denote hydrogen or fluorine, or their pharmaceutically acceptable salts, and the new derived (tetrahydro-1,1-oxido-thiopyran-4-yl)phenyloxazolidine General formula II in which R2and R3are identical or different and denote hydrogen or fluorine, R4means ethyl or dichloromethyl, or their pharmaceutically acceptable salts

The invention relates to novim retinoid compounds of General formula I, II, III, IV with retinoid negative hormone biological activity and/or activity of antagonist retinoids, compositions based on them, a method of determining the retinoid antagonists hormones,the method of treating a pathological state in a mammal, vospriimchivosti to treatment with retinoid antagonist or negative hormone by injection of compound I or II
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