Ointment for animals with antiinflammation, analgetic and wound healing action

FIELD: veterinary.

SUBSTANCE: claimed ointment contains (mass %): fir oil 5.0-10; xeroform 3.0-6.0; and balance: ointment base.

EFFECT: nontoxic and hypoallergic ointment of with high effectiveness and prolonged storage time.

7 ex

 

The invention relates to the field of veterinary medicine and can be used as anti-inflammatory, antiseptic and regenerating means when animal diseases of different etiology.

Known ointment, used in veterinary medicine for the treatment of mastitis, burns, eczema and various skin lesions, which includes a mix of industrial oil with pine resin, beeswax or honeycombs and chalk (see, for example, RU 2107495, 27.03.1998).

This ointment has a pretty sophisticated technology to produce.

Closest to the claimed invention is the ointment "Jahalin", which contains fir oil and ointment base (mixture of vaseline with lanolin). This ointment is adopted for the prototype (see, for example, maple IVAN and other Veterinary drugs in Russia, M., Selhozizdat, 2000, s).

This ointment is well proven in various pathological conditions, but, in the opinion of practicing veterinarians, it has mild antiseptic properties.

The present invention is to develop a highly effective drug for the treatment of skin diseases in animals, as well as wounds and burns with no side effects and has a long shelf life.

The problem is solved due to the fact that the ointment anti-inflammatory, analgesic, wound healing action is via animal contains fir oil and ointment base according to the invention further comprises the kseroforma in the following ratio of ingredients (wt.%):

Fir oil5,0-10,0
The kseroforma3,0-6,0
Ointment baseRest

Technical result provided by the invention, is to improve the effectiveness of the drug by increasing its antiseptic properties at lower concentrations of pine oil, acceleration of regeneration in the treatment of wound healing, as well as increasing the storage time of the claimed drug.

The preparation according to the invention is illustrated by the following examples, which, however, do not cover, and moreover does not restrict the entire amount of the claims of this invention.

Example 1.

Ointment get by a simple mixing of the ingredients. Take (in wt.%): fir oil - 7,0, kseroforma - 5,0, ointment base is a mixture of vaseline with lanolin - rest. The product is an ointment light yellow color with a smell of pine oil and kseroforma.

Ointment named ointment "Haxer".

Example 2.

To determine the skin-resorptive actions ointment "Haxer" 20 rats at the withers and the back was vestigal coat, then on the prepared area is expected inflicted drug obtained in example 1, in the amount of 1 ml of the Area of application of the product was strictly constant. Exposure time was 4 hours daily for 7 days. To ensure complete absorption of the drug rats were placed in special houses to prevent the execution of the drug in animals.

Control animals were housed under the same conditions, but they were treated with distilled water.

After a 7-fold applications was carried out a full examination of animals with different integral of specific indicators, which were used body weight and rectal temperature.

Observation of the animals throughout the experiment showed that the experimental rats in appearance and behavior did not differ from those of the control group. Change of body weight and rectal temperature of the animals of the experimental group throughout the experience was not significantly different from the same parameters in the control animals.

This was followed by extended experiments on studying the weights of the internal organs of white rats exposed to 7-fold effect of the drug. After 7 days of experiments to conduct penetrating ability of the drug through the skin of Wistar rats were killed. In animals, notably a slight increase in the weights of the liver, which is a consequence of VK is Uchenie immune system in response to the effects of the drug. This response allows for a short time to excrete the drug and its metabolites. The weights of other organs was not significantly different in rats experimental and control groups. The experiment showed that repeated exposure of drug intoxication does not develop.

Example 3. Study of the reaction of delayed hypersensitivity (GST).

It is known that the intensity of the reaction GST to different chemical compounds and its duration depend on the timing of the formation and the combined action of various subpopulations of T-suppressor suppressing GST. Therefore, when the induction GST by injecting mice chemical allergens in complete Freund's adjuvant, with no formation of T-suppressors, may increase allergic skin reactions and detection of allergenic properties even weak chemical allergens.

For conducting experiments have been used white mice weighing 18-20 g (10 animals in the experimental and control groups).

Ointment warmed mixed with complete adjuvant's adjuvant and injected in 0.1 ml subcutaneously in the paws of mice. After 6 and 24 hours on 5 animals were killed, and their paws were weighed.

In the analysis of the reaction after 6 hours is not revealed swelling of the paws in the experimental mice, indicating the absence of drug sensitizing properties. By the end of 1st day the swelling was NESN is significant, and significant difference between the weight of the legs in the experimental and control animals (they were administered distilled water at the same dose) was not found.

The obtained data indicate the absence of drug properties that can cause allergic reactions in animals.

Example 4.

Local irritant effect of the ointment "Haxer" on the skin were studied in accordance with the methodological guidelines for the assessment of the effects of chemical compounds on the skin. According to the classification of substances according to the severity of local irritation to the skin ointment "Haxer" refers to the 4th class of danger.

In the study of irritant ointments "Haxer" when applied to the conjunctiva of rabbits were observed on the weak irritants that in no way can serve as an obstacle to the treatment of animals with ulcers of kerato-conjunctivitis, as weak irritant effect leads to exacerbation of the pathological processes and, accordingly, more rapid recovery.

Example 5. The study of reparative properties of the drug was carried out on rabbits weighing 4-5 kg Rabbits in the area of the gluteal muscles on the right did the incisions of the skin, superficial and deep subcutaneous fascia. The cutting depth was reached 0,2 see Through 24 hours after application of the incision wound periodically smeared with ointment "Haxer".

W is the ROI of a series of experiments were carried out on sheep at the age of 3-4 years weighing 35-40 kg Specified animals in the field grits on the left side was making incisions in the skin, subcutaneous fascia damage gluteus length of 10 cm m depth up to 0.5 see Wounds also were periodically treated with ointment "Haxer".

Cytological study of the drug was removed 7.5%alcohol solution and visually observed the development processes of wound healing, paying attention to the growth of granulation tissue, the formation of the crust and other signs of healing. The morphology of the wound healing process was studied using techniques Mporousa and Issacharoff: skim the object glass touched cleaned the wound surface, did 4-5 wound imprint and after drying preparations were fixed and stained by Romanovsky.

Observations show that in the days after the application of the experimental animals ointment "Haxer" was poorly depression, a loss of appetite, increase in local temperature. Wounds filled to the brim with blood clots in the lower corner were detected accumulation of a small amount of clear fluid.

Cytology smears, fingerprints in laboratory animals when using the ointment "Haxer" on the 2nd day found histiocytes, fibroblasts, erythrocytes swollen, discolored. In the cytoplasm of segmented leukocytes revealed favoritemovie MICR who would. After 5 days the fibroblasts had an elongated shape, some on the periphery appear fibrils and degenerative changes of the nuclei. All these fibroblastoma elements together with pleshkani active mesenchyme, fibers, vessels form new tissue, which replaces resolving fibrinous exudate and connects the edges and sides of the wound live young connective tissue. The process was completed in 8-10 days.

In General it should be noted the development of weak hydration phenomena. At the same time, national Academy of Sciences of tissue weight rapidly turned into a strong, national Academy of Sciences of tissue formation, protecting the wound from secondary infection to full fill its granulation tissue and complete epidermization.

Example 6.

Ointment "Haxer" was used in 112 cattle with purulent wounds of the extremities, with a stab injury of the muscles of the croup, 59 pigs with meningitis, aseptic and complicated wounds, 28 dogs and 37 cats, cut, bitten and stab wounds of the extremities, face and belly.

Ointment "Haxer" is well established in the local treatment of wounds of various etiologies. The wound and fill her soaked ointment tampons improved the condition of the wound. To maintain the proper effect had to change the bandages every 4-5 days dog complete cleansing of wounds. Full recovery of the LM is now watched over 7-12 days (aseptic cut, bite wounds) or 15-30 days (purulent, chipped, complicated wounds). However, it should be noted that in the treatment of hard to heal wounds simultaneously used pathogenetic therapy, physiotherapy, etc.

Example 7.

The application of the ointment "Haxer" burns 2nd degree in rabbits and dogs.

Under the experience was 15 rabbits weighing 3 kg and 9 dogs of different ages with different body mass. Burns inflicted on pre-shaven surface of the skin in the back size 5×5 cm with boiling water. The burn occurred bubbles with the liquid, the epidermis hyperemia, painful. Rabbits and dogs have been treated with ointment "Haxer" within 24 hours after application of the burn, once a day during the whole period of experiment (15 days). After 48 hours in all animals burst bubbles appeared moist eczema, anxiety remained. After 4 days the animals appeared granulation roller around the lesion, which was gradually extended, at the same time developed the epithelization process. Full regeneration occurred after 12-14 days.

Thus, it was found that the ointment "Haxer" when applied to the skin diffuses through the sebaceous and sweat glands, gradually absorbed and, thus affecting the circulation of the deep tissues and metabolic processes in them that causes death is acteri, accelerates recovery processes during inflammation, the growth of granulation tissue, epithelialization of wounds.

The ointment used in the treatment of boils, wounds, burns, non-allergic eczema, dermatitis, arthritis, burstow, bruises, phlegmon, felon, traumatic tissue damage in farm and domestic animals.

The ointment is applied in a thin layer on a clean white cloth or gauze, which cover the affected area of the body, then wipe with drug fixed with a bandage or glue BF-6. The ligation is carried out 1 time in 2-3 days. At the same time if necessary, symptomatic therapy and physiotherapy.

The ointment can be applied directly on the affected area, gently rubbing it into the fabric.

Side effects and complications in the use of the ointment was not observed. Contraindications not installed.

The preparation according to the degree of impact on the body relates to the low hazard substances (4th class of danger according to GOST 12.1.007-76).

When this ointment "Haxer it is recommended to apply at the outset of treatment of wound healing, unlike ointment Vishnevsky, which also includes kseroforma (see, for example, Mashkovsky PPM, Medicines, M., 1993, part 2, s). Vishnevsky ointment, as it is known, has a disinfectant, local irritant effect, rez is ltate which improves blood circulation and stimulates the regeneration of the epidermis. However, when you use drug hydrophobic materials (castor oil) is not able to absorb water and exudate, and therefore Vishnevsky ointment is most appropriate to use in the 2nd phase of wound healing. Its use in 1-phase irrational, because hydrocodone the basics (oil) does not allow to absorb wound, because kseroforma at its introduction in hydrophobic base loses its property of podsushivaete, resulting in the wound creates a greenhouse effect, decreasing the possibility of cleansing the wound of pus and necrotic masses, which delays the process of regeneration.

Using the same in the ointment "Haxer" fir oil and kseroforma allows you to save antiseptic properties kseroforma and its drying ability. In addition, this combination of ingredients helps to enhance the penetrating ability of the claimed ointment and lowering the concentration of fir oil to increase the effectiveness of its actions.

The ointment has no local irritation, skin-resorptive effect, allergycausing properties, does not cause reaction of delayed hypersensitivity, does not alter the homeostasis of animals tested.

The drug retains the appearance, color and odor within one year conditional.

Ointment anti-inflammatory, analgesic, wound healing dei is the major animal contains fir oil and ointment base, characterized in that it further comprises the kseroforma in the following ratio of ingredients, wt.%:

Fir oil5,0-10,0
The kseroforma3,0-6,0
Ointment baseRest



 

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