Method and device for cooling polymeric containers for donor's blood

FIELD: medicine.

SUBSTANCE: method comprises cooling blood in the course of donation with forced circulation of air in the working chamber of the first thermostat and setting the container in the second chamber of the second thermostat after donation, where the containers filled with blood together with the containers filled with the same amount of donor's blood imitator are allowed to stand at a temperature close to that of the normal body temperature. The device comprises first thermostat whose first working chamber receives cooling member, fan, and first temperature gauge, first control unit with two commutating contacts, and first temperature controller. The second thermostat has the second working chamber that receives the second heater, second temperature gauge, second control unit, and second temperature controller.

EFFECT: enhanced cooling rate.

5 cl, 7 dwg

 

The invention relates to the field of refrigeration engineering, in particular to methods and devices for heat treatment and rapid cooling of the party of polymer containers with blood, consistently filled with acts of taking donors (donation), with the purpose of its further processing and production of biologically wysokopreznych components, such as fresh frozen plasma.

In accordance with the recommendations of the Council of Europe Manual on the preparation, use and quality assurance of blood components (C-LAB Fortresses. M.B. H. Moscow, 1996) and the Ministry of health from 7.05.04, No. 193 for receiving fresh frozen plasma, i.e. related to the category of biologically vysokopevnostni, donor blood, from which it is derived, after the donation should be quickly cooled to a temperature txp1and txp=(20±2)°C

continue to keep at this temperature for a period of not more than 24 hours.

For cooking as another component of donor blood erythrocyte mass, it must be quickly cooled to a different temperature txp2long-term storage, and txp2=(4±2)°With.

The closest in technical essence and the achieved result of the proposed method is the method of cooling of polymer containers with blood, filled with don the tion and having an initial temperature, equal to the normal temperature of the human body, including the placement of insulated containers in the working chamber of thermostat is equipped with a cooling system, ensuring that the temperature of the air flow, forced circulating in the chamber, at the level of txpcorresponding to the temperature long-term storage of donor blood, which, in turn, causes a gradual decrease in the temperature of blood in containers from tbegto txp(see the patent for useful model N 23330 from 10.06.2002,, IPC F 25 D 25/02, F 25 D 29/00).

The disadvantage of this method, taken as a prototype, is the inability to maintain high cooling rates of polymer containers with blood.

This disadvantage is due to the fact that the closer the blood temperature tkrthe temperature of the cooled air flow rate of lowering the temperature decreases sharply as the curve tkr(τ), describing the dependence of temperature on time, slowly approaches the horizontal asymptote td=const=txpwhich is the constant temperature of the flow of air circulating in the chamber.

The objective of the invention is to increase the cooling rate of polymer containers with blood from the initial temperature tbeg,equal to normal temp is the temperature of the human body t standardsto the final temperature txpcertain regulations, such as temperature long-term storage of donor blood and its components.

The closest in technical essence and the achieved result of the proposed apparatus for the cooling of polymer containers with blood relates thermostat insulated with a working chamber, a cooling system, the unit forced air circulation in the working chamber, a control unit, with the control inputs of which are connected to the temperature sensor and the output of the generator temperature. (see RF patent for useful model No. 23330 from 10.06.02, IPC F 25 D 25/02, R 25 D 29/00).

A disadvantage of the known device, taken as a prototype, is the significant duration of non-stationary processes cooling of polymer containers with blood, placed in the working chamber of thermostat, from an initial temperature equal to the normal temperature of the human body, to the final temperature tarticledefined in the regulatory documents as temperature txplong-term storage of donor blood.

This disadvantage is due to the fact that when thermostat is the magnitude of the signal from the temperature setter on the control input of the control unit, is selected such that the temperature of strirovaniya tarticleimplemented in the working Cham is e, equal to txp.

In this regard, as it approaches the temperature of the polymer container with blood to tarticle=txpthe rate of temperature drop is reduced, and the duration of the transition process, during which the temperature changes from tbegto txpthat is very significant.

The objective of the invention is to reduce the duration of transient non-stationary processes cooling blood from an initial temperature equal to the normal temperature of the human body, to the final temperature, specific regulatory documents as temperature long-term storage of donor blood.

This technical result is achieved in that the cooling method of the party of polymer containers with blood, filled with the donation, by heat rejection to the cooling system with forced circulation of air in the first working chamber of the first thermostat, while after the act of donation, each filled with a polymer container with donor blood is placed into the second working chamber of the second thermostat, together with a similar polymer container, containing the same amount of liquid, which is thermal simulator donor blood, which houses a temperature sensor with cable output, maintained at a temperature close to the Nord is the real temperature t standardsthe human body, then the accumulated batch of containers with blood and the container with thermal simulator is removed from the second working chamber of the second thermostat and put in the first working chamber of the first thermostat, which through cooling systems maintain the temperature of the forced air circulation at a level higher than the temperature of solidification of blood tOPbut below the temperature txpdefined in the regulatory documents as temperature long-term storage of donor blood and its components, and the signal from the temperature sensor in thermal simulator, which demonstrates the achievement within each of the filled polymeric container temperature txp-Δtxpthe temperature of the air in the first working chamber of the first thermostat is raised to txpand in further support at this level, where Δtxp- permissible regulations of the temperature fluctuations of donor blood during long storage. The magnitude of the control signal from the first output of the first temperature setter choose with the ability to maintain in the first working chamber on the signals from the first temperature sensor, a temperature close to the temperature txplong-term storage of donor blood, and the amount of charge of the corresponding signal from the second output of the first temperature setter choose with the ability to maintain in the first working chamber on signals, coming from the first temperature sensor, a temperature tStand tOP<tSt<txpthe magnitude of the control signal output from the second temperature setter choose with the ability to maintain through the second heater to the second working chamber of the second thermostat on the signals from the second temperature sensor, a temperature t2tbspclose to the normal temperature of the human body, while the magnitude of the control signal from the output of the third temperature sensor is chosen with the possibility of actuation of the switch unit when the temperature txpwith hysteresis ±Δtxpwith the possibility of providing state of the switch unit, in which the first and the third input of the switching contacts are closed when the value of the signal from the third temperature sensor in a cooled thermal simulator, to the value of the signal corresponding to the temperature txp-Δtxp.

Apparatus for cooling a batch of polymer containers with blood containing the first thermostat, the first working chamber which is placed the cooling element of the cooling system, the fan and the first temperature sensor, the first control unit with two switching contacts and the first temperature setter, etc the first switching contact of the first control unit is connected with the first phase of the power circuit, the second switching contact is connected to the first end of the cable outlet of the cooling system, and control inputs of the first control unit connected to the first temperature sensor and the output of the first temperature setter, the apparatus additionally introduced a second thermostat containing a second working chamber in which is placed a second heater and a second temperature sensor, the second control unit and the second temperature setter, with the switching contacts of the second control unit included in the power supply circuit of the second heater, and control inputs connected to the output of the second setpoint temperature and a second temperature sensor, the first thermostat inputs of the first heater, the switch unit containing four input of the switching contact, and two output switching contact, as well as control inputs, the third setpoint temperature and the third temperature sensor, the first temperature setter additionally introduced the second output with the second level of the control signal, the first end of the cable outlet of the first heater connected to the second switching contact of the first control unit, with the first input contact of the switch unit coupled to the second end of the cable outlet of the cooling system, with the second input of the switching contact unit PE is clucene coupled to the second end of the cable outlet of the first heater, the first output of the switching contact of the switch unit is connected with the second phase of the power circuit, the third and the fourth input of the switching contacts of the switch unit connected with the first and second outputs of the first temperature setter, the second output switching contact of the switch unit is connected to the input of the first control unit, and to control inputs of the switch unit are connected to the outputs of the third setpoint temperature and the third temperature sensor. Cooling system made in the form of a compression refrigeration unit, a heat element which is made in the form of the evaporator, and the fuel element is designed as a capacitor. The ends of the cable output of the third temperature sensor is equipped with a fork, in the first working chamber of the first thermostat installed socket, the socket of which is mating with the pins of the plug and is connected to the control inputs of the switch unit.

The invention is illustrated graphic material.

Figure 1 presents a side view of a heating Cabinet, consisting of two units, the lower of which performs the function of the first thermostat in the working chamber which is implemented rapid cooling and subsequent maintenance at temperature txpparty of polymer containers with blood, and the upper block vypolnyayuschii second thermostat, in the working chamber which is implemented mode temperature close to the normal temperature tstandardsthe human body; figure 2 presents a view of a heating Cabinet front; figure 3 is an electrical diagram of the first thermostat; figure 4 is an electric diagram of the second thermostat; figure 5 schematically shows the values of the control signals from the first and second outputs of the first temperature setter and an output of the third unit of temperature, and the temperature hysteresis corresponding to the actuation of the first control unit and the switch unit; figure 6 reflect the implementation modes of the temperature at tStand tStimplemented in the working chamber of the first thermostat; 7 presents graphs illustrating how the temperature of the polymer container with blood when implementing known and proposed methods of cooling.

The first and second thermostats included in the proposed equipment does not necessarily have to be embedded in a two-chamber heat chamber and not necessarily the first thermostat in a two-chamber heating Cabinet should be located under the second thermostat.

The first and second thermostats can be performed in separate units, whose structural dimensions are not related to each other and can be razmeshenie only one above the other (although this design is the most convenient in operational terms), but next to each other, and, in General, in different places.

Apparatus for implementing the method includes (figure 1 and figure 2) thermostat 1 and the second thermostat 2.

In the working chamber 3 of the second thermostat 2, provided with a door 4, made two partitions, one of them on the shelf 5 is installed tape-laying 6 to accommodate polymeric container 7 filled with blood, and in another section posted a similar plastic container 8 with a liquid substance, the value of the specific heat, density and thermal conductivity which are compatible with the values of the parameters of donor blood, and so is its thermal simulator.

In the polymer container 8 is placed third (out of the number of sensors used in the proposed instrument) temperature sensor 9, the cable output of which is passed through one of the connecting tubes of the container 8 and is provided on the end plug 10.

As part of a second thermostat also includes (4) a second heater 11 and the second temperature sensor 12 placed inside the working chamber 3, the second control unit 13, the switching contacts of which are included in the power supply circuit, and control inputs connected to the output of the second temperature setter 14 and the second temperature sensor 12.

The first thermostat 1 also contains the heat is aerovane working chamber 15, hosts the heat-removing element 16 of the cooling system in a particular case, the evaporator, the first heater 17, the fan 18, the first temperature sensor 19, the socket 20, the contact socket which is selected mating with the pins of the plug 10.

In the specific case of the cooling system made in the form of a compression refrigeration unit, in turn, contains the compressor 21 and the fuel element in the form of capacitor 22.

Part of the electric circuit (3) of the first thermostat 1 also includes a first temperature setter 23 containing two outputs with different value levels of the control signals, the third temperature setter 24, the first control unit 25, which contains two switching contact, and two control inputs, the switch unit 26 containing four input of the switching contact, the two output switching contact, control inputs, one switching contact of the first control unit 25 is connected with the first phase of the power circuit, the second switching contact of the first control unit connected parallel first cable terminals of the compressor 21 and the first heater 17, the second cable terminals of the compressor 21 and the first heater 17 are connected respectively with the first (K1) and second (K2) input of the switching contacts of the switch unit 26, and suitable for the speaker they output switching contact connected to the second phase of the power circuit, the outputs of the first temperature setter 23 is connected with the third (Q3) and fourth (Q4) of the switching contacts of the switch unit 26, the corresponding output switching contact connected to the first managing input of the first control unit 25, the second managing input connected to the first temperature sensor 19.

With control inputs switch unit connected to the output of the third temperature setter 24 and wires connected to the contact sockets of the socket 20.

Temperature hysteresis set in the apparatus for implementing the method of cooling containers with blood, in the first unit 23 and the third unit 24 is different.

Temperature hysteresis of the third knob 24 (figure 5) is equal to ±Δtthe storage.where Δtstorage. - permissible regulations of the temperature fluctuations stored donor blood relative temperature tstoragemoreover , switching of the switch unit 26 is accomplished, when the temperature of the polymer container 8 with thermal simulator, falling, reaching a value of txp-Δtxp. While previously closed the first input signal input (K1) switch unit 26 moves to open position, and the second input switching contact (K2) enters a closed state, the connection is I second cable outlet of the first heater 17 to the second phase of the power supply network; reverse acts toggle switch unit 26 are performed when the temperature of the polymer container 8, elevating, temperature goes abroad txp+Δtxp.

Temperature hysteresis operation of the first control unit 25 depends on the values of control signals from the outputs of the first temperature setter 23 through the input switching contacts (K3 and K4) switch unit 26 to the control input of the first control unit 25.

When the closed state of the first and the third input of the switching contacts when the power circuit is connected to the compressor 21 of the cooling system, and the input of the first control unit 25 from the first control output of the first temperature setter 23 receives the signal a level at which signals from the first temperature sensor 19 is provided to maintain the temperature in the first working chamber 15 through the cooling system at the level of tSt±ΔtStand tOP<tSt<txp(6).

The value of the temperature hysteresis, for example, in the most simple two-position diagram of the control operation of the compressor is ˜(2÷4)°that is a perfectly valid when implementing the cyclic operation of the compressor 21 refrigeration unit, i.e. in this case the accuracy of the regime tStOK is called very low, determining permissible for refrigeration compressors the duration of the off state, usually part 3-5 minutes

When more complex ways to regulate the temperature regime tStfor example, through the creation of strictly metered heat in addition to cold exposure, the temperature stability can be significantly improved.

When the closed state of the second (K2) and the fourth (C4) input of the switching contacts when the power circuit is connected to the first heater 17, and the input of the first control unit 25 from the second control output of the first temperature setter 23 receives the signal a level at which signals from the first temperature sensor 19 is provided to maintain the temperature in the first working chamber 15 through the first heater 17 at the level of tSt˜txpand the value of the temperature hysteresisthat is a perfectly valid when implementing the cyclic operation of the heater 17 (figure 5 and 6).

The proposed method of cooling containers with donor blood is implemented as follows.

Pre-connected thermostats 1 and 2 to the mains. After the release of thermostats on the stationary temperature in the working chamber 15 of the first thermostat set temperature level t Stand tOP<tSt<txpand the error of maintaining that regime ΔtStis in the range of (2-4)°tenths °With (depending on the method of temperature control).

In the working chamber 3 of the second thermostat 2 set the temperature control at the level of t2tbspat a temperature close to the normal temperature of the human body, i.e. in the range (36-37)°C.

After the donation each filled container 7 is placed in the tape-laying placed on the shelf 5 in the working chamber 3 of the second thermostat 2.

When all cells of a tape-laying 6, except one, are filled containers 7 with donor blood, the tape-laying 6 are removed from the working chamber 3, in its place put the empty cartridge-laying 6 and close the door 4 of the working chamber 3.

In the empty cell of the first tape-laying 6 put the polymeric container 8 with thermal simulator donor blood.

Open the door 4 of the working chamber 15 of the first thermostat 1 and post it tape-laying 6 container 7 and 8. Enter the plug 10 cable output of the third temperature sensor 9 in the slot of the socket 20.

As can be seen from figure 5, when there is no signal from the third temperature sensor 9, or in the range, when the temperature of the container with thermal simulator decreases from tTFI=t beg=(36÷37)°C to tTFI=txp-Δtxpthe first thermostat 1 is operating in the cooling mode, maintaining in the chamber 15 mode temperature tStand tOP<tSt<txpwith precision ±ΔtStdepending on the selected method of regulating the temperature of a substance, such as blood, the values of the phase transition temperature tOPyou can take 0°).

In this temperature range the magnitude of the signal from the third temperature sensor 9 varies from 0 to the threshold value U(3)Por=U(txp)+ΔU(3)thenwhere ΔU(3)then- set when configuring the first thermostat 1 threshold hysteresis indicating the actuation of the switch unit 26.

When the magnitude of the signal from the third temperature sensor 9 is supplied to the control input of the switch unit 26 in the range from 0 to U(3)(txp)-ΔU(3)theninput switching contacts K1 and K3 are closed. In turn, this causes the connection to the mains compressor 21 and the issuance of the control signal from the first unit 23 to the control input of the first control unit 25 such a level that in the working chamber 15 of the first t is rostata 1 mode is implemented at a temperature t St.

Placed in the working chamber 15 of the plastic container 7 with the donor blood and the container 8 with thermal simulator begin to cool, the cooling rate them significantly exceeds the rate of cooling, which is achieved when implementing the known method in the known device (Fig.7).

When the temperature of thermo-physical simulator 8 becomes equal to txp-Δtxpthe value of the signal from the third temperature sensor 9 becomes equal to the first threshold value of a signal from the third temperature setter 24, and is equal to U(3)Por=U(txp)-ΔU(3)thenthat causes the transition of the switch unit 26 in brand new condition. The input switching contacts K1 and K3 are moving to open position, and the contacts K2 and K4 is closed.

In turn, this causes disconnection from the mains power supply of the second cable outlet of the compressor 21 and the cyclic connection to the second phase of the power supply network of the second cable output of the heater 17, and the supply from the first temperature setter 23 to the control input of the first control unit 25 such a level of the predetermined signal, in which the temperature of a closed circulating air flow generated by the fan 18 in the working chamber 15, and further support is moved at the level of t St˜txpwith a sufficiently high accuracy

In this operating mode, the first thermostat 1 is cooled rapidly to a temperature txppolymer containers 7 with donor blood are maintained in the working chamber 15 when the air temperature is also equal to txp.

Next open the door 4 and is removed from the working chamber 15 of the tape-laying 6 polymer containers 7 with donor blood, as well as previously pulled the plug 10 cable output of the third sensor 9 from the socket 20, the container 8 with thermal simulator, opening the door 4 of thermostat 2, return to the lower section of the working chamber 3.

The magnitude of the control signal received at a control input of the switch unit 26 becomes equal to zero. As a consequence, the switch unit 26 again moves the contacts K1 and K3 in the closed state.

The first thermostat 1 again begins to operate in the cooling mode, and after some time its working chamber 15 will again set the mode temperature tSt±ΔtSt.

When the accumulation in the second thermostat 2 new batch of polymer containers 7 with blood above-described method of cooling can be repeated.

As in the proposed method, the cooling control of polymer containers 7 with donor blood is directly the readings of the third temperature sensor 9, placed in the same plastic container 8 with thermal simulator donor blood, regardless of the nature of the changes and fluctuations of temperature in the working chamber of the first thermostat 1 when performing the cooling mode, the quasi-stationary temperature regimes implemented in donor blood and thermophysical the simulator will be almost identical, due to the sameness as the source of initial temperatures and subsequent sameness in every moment of the process of external temperature and heat transfer conditions.

After cooling containers 7 with blood to a temperature defined by the normative documents as the temperature of its long-term storage, either together with the cassette-positioning 6, or separately, can be placed in the working chambers or special units for long-term storage, or cold box for temporary storage.

The proposed method of cooling the polymer containers with blood and apparatus for its implementation can be used when creating expressedly thermostats for completion of mobile donor points.

1. The cooling method of the party of polymer containers with blood, filled with donations and with an initial temperature equal to the normal temperature of the human body, including the placement of containers in the working chamber of thermostat, equipped with a cooling system with forced air circulation and control system, heat removal system cooling to storage temperature and maintaining it at this level, wherein the pre-connected to the mains first and second thermostats are taken for a fixed temperature thermostat, the first of which is implemented by the fast cooling mode and the subsequent maintaining of the temperature of storage, and is implemented in the second mode, a temperature close to the normal temperature of the human body, after the act of donation is filled containers of blood is placed in the second working chamber of the second thermostat, where together with the same polymeric container containing the same the amount of liquid, which is thermal simulator donor blood, and placed temperature sensor with cable output, is maintained at a temperature close to the normal temperature of the human body, then all containers with blood and the container with the simulator move into the working chamber of the first thermostat, which through cooling systems maintain the temperature of the forced air circulation at a level higher than the temperature of solidification of blood, but below the temperature specified in the normative documents in the asked temperature long-term storage of donor blood and its components, about achievement within each blood filled container storage temperature taking into account the value of allowable regulatory documents fluctuations are judged by a signal from a temperature sensor placed in the container with the simulator, refrigerated containers with blood or together with the cassette-positioning, or separately placed in the working chambers thermostats for long-term storage or thermal containers for temporary storage.

2. The method according to claim 1, characterized in that the magnitude of a control signal from outputs of the first temperature setter choose on the signals from the first temperature sensor of the first thermostat with the ability to maintain in the first working chamber mode temperature close to the temperature long-term storage of donor blood, and mode of temperature control with the temperature in the working chamber of the first thermostat lower than the storage temperature of blood, and higher than the solidification temperature of the blood, the magnitude of the control signal output from the second temperature setter choose with the ability to maintain the second working chamber of the second thermostat mode, a temperature close to the normal temperature of the human body, through the second heater is placed in this chamber, on the signals from the second temperature sensor this camera, and the value at rawsumer signal output from the third temperature setter is chosen with the possibility of actuation of the switch unit at a storage temperature of blood with regard to tolerance to temperature variation of blood during its long storage and with the possibility of a state of the switch unit, in which the first and the third input of the switching contacts are closed when the value of the signal from the third temperature sensor in a cooled thermal simulator, to the value of the signal corresponding to the storage temperature is less tolerance for fluctuations in storage temperature.

3. Apparatus for cooling a batch of polymer containers with blood containing insulated thermostat with shelf and tape-laying for placement of polymer containers and the temperature sensor, cooling system and control system, characterized in that it includes first and second thermostats, while in the working chamber of the first thermostat placed the cooling element of the cooling system, the fan, the first heater, the switch unit and the first control unit with two switching contacts, the first of which is connected with the first phase of the power circuit, and the second is connected with the first end of the cable outlet of the cooling system, and control inputs connected to the first sensor temperature and the first temperature setter, the working chamber of the second thermostat consists of two sections, one of which on the shelf is installed tape-laying to accommodate containers of blood, and the other cassette-ukladki is to host a similar containers with a liquid substance thermal simulator donor blood, and in the working chamber of which is placed a second heater, the second temperature sensor, the second control unit and the second temperature setter, with the switching contacts of the second control unit included in the power supply circuit of the second heater, and control inputs connected to the output of the second setpoint temperature and a second temperature sensor, and the switch unit of the first thermostat has four input of the switching contact, the two output switching contact, and control inputs connected to the outputs of the third setpoint temperature and the third temperature sensor, and the input switching contact is connected to the cooling system, the second with the first heater, third and fourth outputs of the first temperature setter, and the first output pin is connected with the second phase of the power supply, the second with the first control unit.

4. Apparatus according to claim 3, wherein the cooling system includes a compression refrigeration unit, a heat element which is made in the form of the evaporator, and the fuel element is designed as a capacitor.

5. Apparatus according to claim 3, characterized in that the receptacle for connection with the control inputs of the switch unit of the ends of the cable output of the third temperature sensor RA is Medina in the working chamber of the first thermostat.



 

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5 cl, 3 dwg

FIELD: medical engineering.

SUBSTANCE: method involves continuously measuring electric current amplitude flowing via piezo-ceramic elements of ultrasonic oscillatory system when using mechanical manual tube cross-clamping mechanisms during ultrasonic action applied to suture formation zone. Current amplitude changes are controlled in welding. The condition of current amplitude changes under measurement becoming equal to zero being satisfied, ultrasonic action is to be switched off providing in this way optimum suture quality.

EFFECT: high reliability in sealing various blood containers types.

2 dwg

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