Ointment for topical application

FIELD: pharmaceutical industry, in particular anesthetic and vasodilating ointment.

SUBSTANCE: claimed ointment is prepared on the base of fine dispersed formulation contains apitoxin extract melittin, camphor, lavender, rosemary and eucalyptus oils and revitalin in specific component ratio. Ointment of present invention is useful in treatment of reumathysm, muscle and joint diseases, myodynia, radiculitis, ischias, neurodynia, polyneuritis, etc.

EFFECT: ointment with reduced apiotoxin toxicity, decreased side effects and improved therapeutic effect.

2 tbl

 

The invention relates to medicine, namely to the pharmacy, and for the composition of ointments for external use.

In medicine it is widely known compositions for the treatment of patients with rheumatism, diseases of the muscles and joints, hypertension, nonspecific polyarthritis, myositis, lumbosacral radiculitis, sciatica, neuralgia, polyneuritis, myalgia, such as rubbing the mixture diet" and other compositions containing snake I bee poisons "Vibratex", "Wipein", "Apistan". The disadvantages of the compositions containing snake and bee venoms are high idiosyncrasy, a large number of contraindications.

Closest to the claimed composition according to the achieved result is the ointment "Viprosal"containing poison lebetina Viper, camphor, salicylic acid, pine oil, petrolatum, glycerin, paraffin wax, emulsifier and water. However, due to the fact that the poison lebetina Viper is a coagulant (a substance that increases blood clotting), the disadvantages of this drug may include a narrow therapeutic range - the difference between safe and toxic doses; use vaseline, which forms on the skin of a thin film, making it difficult to penetrate in the blood of active medicinal substances; frequent individual intolerance of the drug, manifested in the form of nausea, vomiting, malaise, chills, increasing the temperature, edema, urticaria, pain in the lower back and joints, cramps, fainting state, etc. in Addition, the drug has numerous contra-indications - diseases of the kidneys, liver and pancreas, diabetes, cancer, tuberculosis, severe infectious diseases of the haematopoietic system, circulatory failure, etc.

The aim of the invention is to obtain an effective anesthetic and vasodilating agent based components of bee venom, with improved tolerability and fewer side effects by reducing the toxicity of bee venom by removing fractions, causing adverse reactions. The ointment can be applied to ensure, in particular, patients with rheumatism, diseases of the muscles and joints, hypertension, nonspecific polyarthritis, myositis, lumbosacral radiculitis, sciatica, neuralgia, polyneuritis, myalgia, and many other diseases.

The delivered result is achieved by creating ointment anesthetic, a vasodilator, which includes extract of bee venom - melittin, tincture of Arnica, camphor, lavender oil, rosemary and eucalyptus oils, revitalin, in the following ratio of components, in grams per 100 g of product:

extract of bee venom is - melittin
(Apis mellifera toxin)0,003-0,010
lavender oil
(Aetheroleum lavandulae)1,0-5,0
camphor (Camfora)3,0-5,0
tincture of Arnica
(Tinctura amicae)2,0-7,0
rosemary
(Aetheroleum rosmarinus)1,0-5,0
eucalyptus oil
(Aetheroleum eucalyptus)1,0-5,0
revitalin (Revitalin)1,0-3,0

As other additional substances in the composition of ointments can be introduced auxiliary substances (ingredients)that do not affect the overall effect of the drug, having an auxiliary action which are not the subject of the present invention.

The proposed ointment on physico-chemical properties is a homogeneous fine-ointment from white to light yellow color with a smell of camphor and lavender. Its main component is an extract of bee venom - melittin. It has anti-inflammatory, analgesic effect. In addition, it will expand the cerebral vessels and the coronary vessels, stimulates the pituitary-adrenal system. The composition of the ointment so the e entered this active substance, as the tincture of Arnica is a remedy irritant, anti-inflammatory, antibacterial action, contributing to the formation and release of physiological stimulators of immune processes, activating the local blood flow and accelerate the resorption of hemorrhages. Camphor - medicinal substance from the group of stimulants nervous activity. When skin is well absorbed, has a local irritant effect, and has antiseptic and insecticidal properties. Lavender, rosemary, eucalyptus oil affect the receptors in the skin, accompanied by the release of endorphins and other substances that regulate pain sensitivity and vascular permeability. Possess analgesic and anti-inflammatory effects. Revitalin - causes a significant increase in skin temperature, increases blood flow to the depth of the muscles, which promotes better penetration of the blood of active components of the drug.

Testing the claimed ointment was held at the Moscow Institute of non-traditional methods of treatment and the laboratory of clinical pharmacology and doping control MNPCS.

At the Moscow Institute of non-traditional treatment methods declared ointment was used as an external tool by rubbing in the field of pain the feeling which deposits a layer of about 1-2 mm. Depending on the intensity of pain during the procedure was repeated up to 3 times a day. Active ingredients of ointments is better absorbed when applied the ointment in the form of compress: on the processed surface was applied the ointment, covered with plastic wrap and tied with a piece of fine linen. Compress kept preferably not less than half an hour. With good treatment outcome was no pain, improved overall health, normalizability sleep had smoothed out or disappeared neurological symptoms. If a satisfactory outcome of treatment decreased pain and objective symptoms. In the absence of dynamics in the subjective and objective data, the treatment results were evaluated both with no effect. For testing composition were formed the control group respectively from 20 people with rheumatoid arthritis, 15 with rheumatic polyarthritis, 20 from deforming osteoarthrosis and 15 with neuralgia and myositis - a total of 70 people. As can be seen from table 1, 48.6 per cent of the total number of patients obtained a good result, 44,3% - satisfactory, at 7.1 percent, the effect was not observed. Thus, the treatment efficiency of the claimed ointment made up 92.9%.

In the laboratory of clinical pharmacology and doping control MNPCS the aim of the study was to assess the effectiveness of the ointment in the practice of sports medicine. Studies were n is the athletes, the edge-runner mills middle distance with traumatic lesions of tissues and musculoskeletal system (light and moderate) of the lower extremities.

The total number of subjects: 30.

The control group (10 athletes) did not apply the ointment.

Qualification: msic - 6, MC - 12, kms - 12.

Age: from 18 to 28 years.

In accordance with the conditions for all the subjects at the beginning and end of the experiment (1st and 20th days) passed comprehensive testing and medical examination, and 5 days after cessation of use. The overall health of the athletes was evaluated by performing the ultimate muscle work speed-increasing nature to "opt-out" Jogging on redbana "Quinton" (USA). Among the biochemical parameters were carried out observations on the concentration of urea, lactate, glucose, protein in the blood by conventional methods. The effects of the claimed ointment on physical performance are presented in table 2 (% to control).

Conclusions MNPCS:

- the claimed ointment in exchange application within 20 days restores the overall sports performance athletes;

- identified the antioxidant activity of the drug in the same time frame;

- any side effects (allergic reactions, pain, prolonged redness, itching, swelling), as well as negative organoleptic the fir properties of the drug is not detected;

- in the ointment is not detected doping drugs and their metabolites;

the ointment may be recommended in sports medicine practice.

The efficacy of the claimed ointment as a vasodilator of the following examples.

Example 1. Patient X, 60.

Was in therapeutic Department of the City clinical hospital № 70 of Moscow in the autumn of 2005.

Diagnosis: chronic obstructive bronchitis in the acute stage. Coronary heart disease: Atherosclerotic cardiosclerosis. Varicose veins of both legs. Venous insufficiency stage 2.

Complaint: shortness of breath, dry rales, edema of the feet of both legs, trophic ulcer of the right big toe of the left foot, the big toe of the left foot.

Objectively: the state of moderate severity. Dry, wheezing in the area of the mediastinum. Hypersthenics. Shin pasty, varices on both sides, was more expressed on the left leg. Feet swollen, centioni. On the left foot big toe trophic ulcer 0.5×1 see

Rheography of the lower extremities. Geographical index (RI) reduced - 0.5 cm, the volume is reduced. Obstructed venous outflow.

Appointed: rubbing the claimed ointment five times a day in the feet and legs under control prothrombinase index and rheography.

On day 5 of treatment were sleeping on the EKI stop, almost went zianoticnae.

Rogramme lower extremities. RI increased to 1.0, the Volume increased by 30%, improved venous return and vascular tone. Prothrombin 95%.

On the 15th day of treatment: the skin of the lower limbs supple, regular color. Venous nodes slept. Prothrombin 85%. Ulcer epithelials. On rogramme: RI-2,0. The pulse wave has increased to 2.5, see

Example 2. Patient Y, 52.

Was in the seventh division of Infectious clinical hospital No. 1, Moscow in the autumn of 2005.

Diagnosis: bronchial asthma, lung during (not hormone-dependent). Influenza (NF+) average for; was admitted with complaints of weakness, fever up to 38°, sweating, shortness of breath.

History: acutely Ill in October 2005, the temperature Rose to 38.2°C. it Became difficult to breathe. Was treated symptomatically: breast collection, aminophylline, 1 I. × 3 times a day. No improvement occurred. Went to the polyclinic hospital in IKB No. 1-7 CTD.

Fluoroscopy. Signs of pneumosclerosis: roots extended; the bronchial tree with the sign of obstruction. Blood analysis: HB 12,0, L 5,6, er 5,02, p 8, p 60, e 2, ESR 8 mm/h

At the first stage of treatment, along with the usual regimen added therapy ointment claimed composition through its rubbing on the front surface of the chest 3 times a day and the back surface 2 of the RA is as a day. On the 5th day of treatment due to the significant improvement of respiratory functions have ceased shortness of breath, normalized body temperature to 36.5°With, decided to continue treatment with the ointment of the claimed composition with the complete abolition of previous drug therapy. Treatment ointment lasted 15 days.

Chest x-ray after the procedure: bronchopulmonary tree almost completely organised, hemodynamics in a small circle is normalized, left signs of overload of the right ventricle. Blood urine from 29.10 without pathology.

Table 1
Name diseasesThe number of patientsSignificant improvementImprovementWithout changeDeterioration
Rheumatoid arthritis201271-
Rheumatoid arthritis15861-
Deforming osteoarthritis205132-
Neuralgia and myositis15951-
Total: absc70 34315-
%10048,644,37,1-

Table 2
GroupInitial stateOn the 20th day5 days after receiving
Healthy athletes100,2of 99.1100,3
Control79,383,194,9
Experiment75.4119,1102,4

Ointment obezbolivaushee, vasodilator, containing extract of bee venom - melittin, camphor, tincture of Arnica, lavender, rosemary and eucalyptus oils, revitalin, in the following ratio of components, in grams per 100 g of product:

Extract of bee venom - melittin0,003-0,010
(Apis mellifera toxin) tincture of Arnica
(Tinctura amicae)2,0-7,0
Camphor (Camfora)3,0-5,0
Lavender oil (Aetheroleum lavandulae)1,0-5,0
Rosemary oil (Aetheroleum rosmarinus)1,0-5,0
Eucalyptus oil (Aetheroleum eucalyptus)1,0-5,0
Revitalin (Revitalin)1,0-3,0



 

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