Agent for treatment of dermatomycosis

FIELD: medicine, veterinary science, pharmacy.

SUBSTANCE: invention relates to an agent used in treatment of dermatomycosis. Agent comprises 2-mercaptobenzothiazole, glycerol and dimethylsulfoxide. Invention provides enhancing effectiveness in treatment of patients with trichophytosis and microsporia disease. Proposed agent is harmless, useful in using, allows reducing treatment period and decreases the labor intensity in its using.

EFFECT: improved and valuable properties of agent.

4 ex

 

The invention relates to veterinary and medical pharmacology and Mycology, in particular the production of drugs for the treatment of diseases of animals and humans dermatomycosis.

Zooantroponoznyh ringworm - microsporia and trichophytosis is highly infectious diseases that pose a significant risk to human health and animals. The increase in the incidence of ringworm involves the need to expand research and development of effective, affordable treatments.

Known use for the treatment of trichophytia and microspores of the preparations of iodine, chlorine, antibiotics (griseofulvin, nystatin), sulfur (kN. Mashkovsky A.D. "Drugs", M, "Medicine", 2000; kN. Golubev IA "Ringworm animal), 1970; kN. Nabiev F.G., Akhmadeev R.N. Drugs for veterinary use", Kazan, 2000), which require long-term and repeated use and do not always provide a high therapeutic effect, some of them cause side effects.

Closest to the proposed invention is a drug for treatment of ringworm animal, containing in its composition of 2-mercaptobenzothiazoles, polyethylene oxide, sodium carboxylmethylcellulose, glycerin, distilled water (Fedotov V.P., Kozlenko CENTURIES and other Experimental evaluation of fungicidal activity of 5%-memetically MAZ is in the external treatment of Microsporum // W. West. dermat. and venerol. - 1987, No. 3, pp.69-71). This drug is a topical composition which is applied 15-20 times 2 times a day, which greatly increases the complexity of its application and limits its practical use in the cattle industry in the stress and side effects when you commit animals, do not reduce the duration of quarantine for the population.

In the claimed invention, the aim was to produce highly effective, harmless, easy to manufacture, easy to use tool for the treatment of dermatomycoses, which will reduce the treatment time and reduce the complexity of the application.

This is achieved by the fact that the drug for the treatment of trichophytia and microspores containing 2-mercaptobenzothiazoles (2 ILO) and glycerol enter the sulfoxide (DMSO) in the following ratio, wt.%:

2-mercaptobenzothiazoles1.5 to 2.5
Glycerin5,0-10,0
The sulfoxideTo 100.0

Chemical compound 2-mercaptobenzothiazoles known and described in literature.

2-Mercaptobenzothiazoles (2 ILO) produced by interaction of aniline CS2and S (250°and the pressure of 3.2 MPa) and by the reaction of o-clinicamente with NaSH, followed by processing of the ow obtained o-mercaptopurine. 2 the office - crystalline yellow substance with a melting point 180,2-181,7°, mol. mass 167,25, practically insoluble in water, soluble in ethyl ether, glacial acetic acid, ethanol, aqueous solutions of hydroxides and carbonates of alkali metals (kN. Chemical encyclopedia, 1992, Vol.3, pp.61-62).

Chemical compounds dimethyl sulfoxide and glycerol are known, are used in medicine. The first is for the treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis deformans and other diseases. (kN. Mashkovsky PPM "Drugs", Harchikov, "Torching", 1998, T.1, C.177-178). Glycerin is used as a solvent, the basis for the preparation of ointments, liniments, collodion and other substances (see Great medical encyclopedia, 1977, V.6, S-142).

Dimethyl sulfoxide (DMSO) - (CH3)2SO - hygroscopic liquid without color and odor, melting point of 18.45°With (easy pereohlajdenia), boiling point - 189°S, soluble in water, ethanol, acetone, diethyl ether, With6H6. Get DMSO oxidation (CH3)2S with oxygen in the presence of catalytic amounts of nitrogen oxides or other compounds vectors O2and at oxidation (CH3)2S oxides of nitrogen, a solution of N2O2upon cooling, hydrolysis (CH3)2 2, (CH3)2SBr2.

DMSO is a widely used solvent, a component of cosmetic and medicinal products, promotes the penetration of drugs through the skin (see Chemical encyclopedia, 1990, Vol.2, p.119-120). Also has a bacterial plankton and fungistatic effect (see Great medical encyclopedia, 1977, Vol.7, S-326).

Glycerin3H5(OH)3is a trivalent alcohol is a colorless, transparent and syrupy liquid, odorless, sweet taste, with a specific gravity of 1.26, boiling point 290°, hygroscopic, water and alcohol are miscible in all proportions, insoluble in ether and chloroform, are not miscible with fatty oils. Derived from vegetable and animal fats by saponification their caustic alkali solution or when exposed to superheated steam, or synthesized from propylene, are used as the basis for liquid ointments, as a solvent of drugs and as a softening agent (Deerwalk et al. Drugs in veterinary medicine. M: "Kolos", 1977, p.98).

Introduction to the composition of dimethyl sulfoxide, reinforcing its fungicidal activity, allows you to get a new therapeutic agent, in the form of liquid dosage forms with a higher fungicidal activity, which is quickly absorbed and penetrates into the deeper layers of the skin, ensure the sustainable fast acting, when the treatment time is reduced up to 7-14 days.

Example 1. The preparation of therapeutic agents.

In a porcelain mortar were placed 1.5 g of 2-mercaptobenzothiazoles, carefully rubbed with a pestle. Then the mortar was added 5.0 g of glycerol and rubbed at room temperature until a homogeneous consistency. Then portions with thorough stirring was added dimethylsulfoxide 93,5 g to obtain a homogeneous mass.

Protivogribnye activity was studied on pure cultures of fungi. The effectiveness of the composition was determined by the growth of mycelium in pure cultures of fungi, pathogens trihofitii and Microsporum Trichophyton verucosum seu faviforme, T.gipseum seu mentagrophytes, T.rubrum, Mycrosporium lanosum seu canis, by well-known methods (Pershin GN. "Methods of experimental chemotherapy", M, Medicine, 1971, S). The observations were carried out for 14 days. at a temperature of 26°C. sensitivity to the drug is determined by its minimum concentration at which growth of the fungus was not observed. Fungicides determined by reseeding inoculum of the fungus from tubes in which no growth of the fungus, on a clean environment Saburo. Observations were carried out over 30 days, recording the absence or presence of fungus growth.

The composition is highly fungistatic and fungicidal activity against pathogenic fungi, pathogens trihofitii and microspores in to the ncentratio 0.001 to 0.01%.

Example 2. A remedy is prepared analogously to example 1. Used by applying to the affected skin of animals until a thin wet, shiny layer (0.2 ml per 1 cm2) 1-3 times with an interval of 24 hours depending on the extent of damage without removing crusts.

Cured 105 dogs, 133 rabbit, 204 calf, patients trichophytosis, and 139 dogs and 145 cats, sick microsporia. Recovered all the animals. Therefore, therapeutic effect funds amounted to 100%.

Example 3. A remedy is prepared analogously to example 1, but 2-mercaptobenzothiazoles take 0.5 g, 4.0 g glycerol, dimethyl sulfoxide 95,5, the Tool was applied by coating on the affected areas until a thin wet, shiny layer (0.2 ml per 1 cm) 1-3 times with an interval of 24 hours depending on the extent of damage without removing crusts.

Effectiveness of treatment was 88-92%.

Example 4. A remedy is prepared analogously to example 1, but 2-mercaptobenzothiazoles take 2.5 g of glycerol 10.0 g, dimethyl sulfoxide, 87,5 Used by applying on the affected areas until a thin wet, shiny layer (0.2 ml per 1 cm2) 1-3 times with an interval of 24 hours depending on the extent of damage without removing crusts.

The treatment efficiency was 100%.

The introduction of mercaptobenzothiazoles in the composition in a higher concentration is the second does not increase efficiency, and lack of concentration does not provide sufficient efficiency.

The proposed dosage form 2-mercaptobenzothiazoles tested us with a positive result for ringworm (trichophytosis and microsporia) laboratory (cavy 26, rabbits 221), animals (dogs 460, cats 180), selskokhosaistvennyh animals (calves 504, gilts 410), fur-bearing animals (89).

Remedy are harmless to animals, vsokoeffectiven, it is convenient to manufacture and use, reduces treatment time up to 7-14 days, with the multiplicity of treatment 1-3 times with an interval of 24 hours. While the daily use of the prototype appearance of hair marked only in 10-20 days of starting treatment, the recovery of all animals came to 20-30 a day.

The proposed tool will find wide application both in the private sector and in animal husbandry for ringworm animal.

The treatment for trihofitii and microspores containing 2-mercaptobenzothiazoles and glycerin, characterized in that it further comprises dimethyl sulfoxide in the following ratio, wt.%:

2-Mercaptobenzothiazoles1.5 to 2.5
Glycerin5,0-10,0
The sulfoxideRest



 

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