Liposomal concentrate for treatment and care for hair of dry type

FIELD: perfume and cosmetic industry, cosmetics.

SUBSTANCE: invention relates to producing agents used for hair care. The liposomal concentrate used in treatment and care for hair of dry type comprises biologically active substances of mammalian and/or vegetable origin wherein it comprises liposomal suspension consisting of phospholipids and lipids with included chloroform extracts of herbs, red pepper alcoholic tincture, glycerol, and also nipagin and nipasol as preserving agents, and perfume and water wherein components are taken in the definite quantitative content. The concentrate possesses the high biological activity, it recovers the hair structure, stimulates the cutaneous circulation being without cutaneous-irritation and sensibilizing effects.

EFFECT: improved and valuable properties of concentrate.

4 ex

 

The technical field to which the invention relates.

The invention relates to medicine, in particular to cosmetology, and can be used for the production of liposomal concentrate for the treatment and care of dry hair type.

The level of technology.

Cosmetics for care of hair must possess not only curative activity, but adequate organoleptic properties. The functional purpose of such funds is in action liposomal concentrate on the scalp for faster hair growth, normalization of regulatory processes in the sebaceous glands and the root system, stabilization and regeneration of the hair structure, the elimination of inflammatory processes in the scalp causing irritation, dryness, flaking, give hair a healthy Shine, elasticity, softness and simultaneous fixing of the hairstyle.

The combination of the desired properties necessitates the use in the formulation of cosmetic products of the complex synergy of existing biologically active components.

The most effective recognized the use of biologically active substances derived from plant materials.

Known cosmetic products for hair care, using various plant extracts. One of those cf the of funds comprises a biologically active components of the mixture water-spiropiranovye or aqueous-alcoholic extracts of medicinal plants, acid salicylic, boric, amber, lemon, castor oil, burdock, conopeptide, a mixture of amino acids hydrolisate, drugs, vitamins, glycerin, urea, ethanol, solubilizer, perfume, dye and water /Pat. EN 2067444, a 61 K 7/48, 1996/.

Included in the acid together with ethyl alcohol antiseptic, anti-inflammatory, keratolytic and laborataries effect, causing a rush of blood to the surface of the skin, increasing blood circulation in the capillaries of the skin and in the area of hair follicles. Castor oil prevents the degreasing of the skin, makes hair silky and shiny. Burdock helps to activate hair growth, strengthens hair follicles, destroys dandruff.

Individual components, such as vitamins, amino acids, cropeptide enhance the effects of nutrients on plant extracts, normalizes the activity of sebaceous glands, stimulates the metabolic processes in the roots of the hair, improve the structure, prevent cross-section and give hair a healthy Shine and appearance.

The disadvantages of the balsam are narrow spectrum of activity, excessive drying of the scalp, the presence of irritating components, which may not be suitable for all types of scalp, effect on hair shaft to restore it is not enough.

Famous balm for hair, including to the complex of biologically active substances of plant and animal origin, such as propolis extract, licorice root extract, extract of birch leaf, nettle extract, cocoa, honey, millet oil, broth oat straw, pine and peppermint oil, and citric acid, glycerin, flavoring and water, according to the invention further comprises a polyethylene oxide gel, the yolks of eggs and sodium benzoate /Pat. RU # 2120276, a 61 K 7/06, 20.10.1998. Bull. No. 03/.

Positive property balm is the presence of vegetable oils that soften and vitaminizing the skin, preventing the mechanisms of aging-related oxidation processes (antioxidant effect)compensate for the loss of sebum when shampooing, adverse atmospheric influences, and also have a mild deodorizing, antiseptic and promote faster healing of abrasions by the addition of propolis.

Propolis is a fungicide and bacteriostatic, which increases shelf life of the cosmetic product, and also has a regenerative and anti-inflammatory effect. The yolk of an egg is a source of lecithin - a natural surfactant (detergent), which helps remove dirt hair, softens and vitaminineral the skin, exhibits antioxidant activity.

In addition, the yolk of chicken eggs and the propolis used in Narodne is the first medicine to prevent breakage, dry hair and restore their growth.

Citric acid gives the hair Shine and elasticity, provides regulation of the pH of the funds, as a result does not require the use of mouthwash.

Glycerin provides a soothing and moisturizing effect on the skin of the head, and also has good permeability, promotes the transport of substances through the epidermis. Fir oil, being a good bacteriostatic, helps to reduce the likelihood of skin diseases and improves circulation.

Specified balm provides effective action on the scalp, but the impact on the hair shaft is not enough. Also the disadvantages must be attributed to the lack of penetration balm in hair roots and medelhavsmuseet of action of biologically active components in its composition.

The closest in technical essence and the achieved positive effect and adopted for the prototype is hair gel, containing biologically active additive of plant and animal origin, gel-forming components, preservative, perfume and purified water, as a dietary Supplement, it contains a suspension of liposomes from phospholipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile, St. John's wort and she is uly, as the gelling component is ammonium salt of Recoletos copolymer of acrylic acid and polyallylamine esters of pentaerythritol, as preservative methyl and propyl esters of peroxybenzoyl acid and further comprises glycerin, paraform and dye at the following content, wt.%:

The suspension of liposomes8,0-10,0
Glycerin2,5-3,0
Methyl ester paraoccupational
acidof 0.2-0.3
Propyl ester paraoccupational
acid0,08-0,1
Paraform0,02-0,03
Ammonium salt of Recoletos
copolymer of acrylic acid and
polyallylamine esters of pentaerythritol0,8-1,0
Perfume0,1-0,2
Dye0,001-0,002
WaterRest

(see Pat of the Russian Federation No. 2150267, class a 61 K 7/06, epubl).

The disadvantages of this hair gel is a low concentration of biologically active substances and inadequate provision of therapeutic action on dry hair

Disclosure of the invention.

Object of the present invention is to provide a therapeutic liposomal concentrate for dry hair with prolongation of action of biologically active components, while maintaining favorable organoleptic properties of the concentrate.

Dry hair seem rough, lacking Shine and break easily. The cause of dry hair can be too dry scalp due to reduced secretion of sebum from the sebaceous glands. When dry hair fat content and moisture in the skin of the scalp is sufficient.

The technical result that can be achieved using the present invention is to provide cosmetic steps on dry hair due to the increase of the concentration of biologically active components creation of phyto compositions, as well as recruiting staff, providing moisturizing, nourishing, firming and catalytic effect on the sebaceous glands, as well as preserving favorable organoleptic properties of the concentrate and reduce its value.

The technical result is achieved by liposomal concentrate for dry hair, containing biologically active additive of plant and animal origin, in which he contains a suspension of liposomes of f is stolipinovo and lipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile flowers, calendula, a preservative, glycerin, dye, perfume and water, this dietary Supplement also contains herbal extracts of burdock, walnut, aloe, hops, focusof, fruits, carrots, leaf sage, lemons, garlic, vitamin a, and oils - castor, tea tree and wheat germ, alcohol tincture of Cayenne pepper, glycerin, preservative - nipagin, nipazol, perfume, dye and water brackish spring at the following content, wt.%:

0,08-0,1
The suspension of liposomes containing
the herbal extracts of burdock, nettle,
chamomile flowers, calendula, walnut
nut, aloe, hops, focusof,
fruits carrots, leaf sage, fruit
lemon, garlic and castor oil,
tea tree and wheat germ25,0-30,0
Vitamin a0,001-0,002
Alcohol tincture of Cayenne pepper12,0-15,0
Glycerin2,5-3,0
Nipaginof 0.2-0.3
Nipazol
Perfume0,1-0,2
Dye0,001-0,002
The water is brackish springUp to 100%

The entity receiving liposomal concentrate for the treatment and care of dry hair type is the following. Liposomal suspension is prepared by evaporation in reversed phase. Charged to the reactor a solution of phospholipids of natural origin and chloroform extract of medicinal plants. The formation of the lipid vesicles are under vacuum at a temperature of 40±1°C for 2.5 hours to remove the chloroform. A pair of chloroform is cooled in the reflux, are condensed and fed to the extraction of medicinal plants.

In the mixer pour brackish spring water 64,62-59,40 wt.% and when the stirrer fall asleep nipazol 0.08 to 0.1 wt.% and nipagin of 0.2-0.3 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes of 25.0-30.0 wt.%, vitamin a 0.001 0.002 wt.%, tincture of Cayenne pepper 10.0 wt.%, dye 0,001-0,002% by weight and the perfume of 0.1-0.2 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

To prepare a chloroform extract of dried herbs and chopped herbs Lou is a, nettle, chamomile, calendula, walnut, aloe, hops, focusof, carrots, sage, lemon and garlic mixed in equal amounts and incubated under a germicidal lamp for 3 hours. The mixture is then poured chloroform in the ratio of 1:20, mix and insist in a dark place for 2-3 days.

Grass depleted in chloroform extraction, pour a 40%solution of ethyl alcohol for extraction of biologically active components, passing in a water-alcohol fraction.

After extraction, the suspension is stirred and separated supernatant.

As a result of research for selecting the optimal concentration of all components of the liposomal concentrate for the treatment and care of dry hair type, we have determined that a decrease in the concentration of botanicals less than 10 wt.% reduces the biological activity of the finished product, the increase in the concentration of botanicals above 15 wt.% impractical because biological activity is not increased, while increasing the consumption of raw materials, that is, it is economically disadvantageous. The decrease in the concentration of the alcoholic tincture of Cayenne pepper less than 10 wt.% does not stimulate in the right measure skin blood flow, and increasing the concentration above 10 wt.% much irritating to the scalp, which is not suitable for people with high h is stateliest scalp and may cause allergic reactions. The decrease in the concentration of glycerol below 2.5 wt.% leads to a decrease moisturizing effect of liposomal concentrate, increase higher than 3.0 wt.% economically impractical because of the moisturizing effect remains unchanged. The decrease in the concentration of nipagin below 0.2 wt.% reduces the bactericidal properties of the finished product, and increasing the concentration above 0.3 wt.% causes irritation of the scalp.

The decrease in the concentration nipazola below 0.08 wt.% reduces the bactericidal properties of the finished product, and the increase in concentrations above 0.1 wt.% causes irritation of the scalp. The decrease in the concentration of odorants less than 0.1 wt.% does not need a pleasant aroma to the finished product, and increasing the concentration above 0.2 wt.% causes scalp irritation and allergic reactions. The decrease in the concentration of dye is lower than 0.001 wt.% gives the finished product the desired shade, and an increase in the concentration of dye above 0.002 wt.% causes scalp irritation and allergic reactions. As for the temperature, then reducing it below the 20°slows the reaction rate and increases the cooking time of the finished product, while the temperature increase of more than 30°unacceptable, as it may be the destruction of liposomes. When reducing mixing time less than 20 minutes homogeneity wt is s, increase mixing time associated with the consumption of electricity, which is impractical from the point of view of economy.

Thus, the ratio of the components of liposomal concentrate for the treatment and care of dry hair type optimally and achieve the desired effect.

Liposomal concentrate for the treatment and care of dry hair type with respect to the prototype has the following positive aspects.

Use as biologically active additives to the suspension of liposomes from phospholipids and lipids of animal and/or vegetable origin include chloroform extracts of twelve herbs: burdock, nettle, chamomile, calendula, walnut, aloe, hops, focusof, fruits, carrots, leaf sage, lemons, garlic, vitamin a, and castor oils, tea tree and wheat germ.

Introduction to the formulation of additional botanicals, as well as the use of vegetable oils and tinctures pepper increases the concentration of biologically active substances included in the liposomal concentrate, due to which the claimed formulation is used as a prophylactic and therapeutic agent.

The extract of these herbs includes over a full range of biologically active components that are required for the hair roots, so is for rods. It contains carotenoids, Tocopherols and flavonoids contained in the grass burdock, nettle, chamomile flowers, calendula, walnut, aloe, hop cones, fukusa, fruits, carrots, leaf sage, fruit of the lemon, which have antioxidant properties, inhibiting the formation of excessive amounts of peroxide compounds, corroding cell membranes in the scalp. In addition, these compounds possess anti-inflammatory, capillary, desensitizing effect. Regulate lipid, mineral, water exchanges, the regeneration of the epidermis of the skin, improve the activity of hair follicles, have bactericidal and fungicidal properties, have estrogenic activity. Together with ascorbic acid, flavonoids are involved in redox processes, which improves cell respiration scalp, increasing the absorption of oxygen skin tissues.

Azulene, sesquiterpenoid in the grass burdock, chamomile flowers, calendula, walnut, aloe, hop cones, fruits, carrots, leaf sage, fruit lemon, castor oils, tea tree and wheat germ, anti-inflammatory and antiallergic effect, thereby reducing the irritation of the scalp, helping to reduce the formation of dandruff. Essential Masakazu a tonic effect on the metabolic processes. The presence of unsaturated fatty acids and their triglycerides in the grass burdock, chamomile flowers, calendula, walnut, fruit, carrot, castor oils, tea tree and wheat germ promotes nutrition and elimination of vitamin a deficiency, improves lipid metabolism in the tissues of the skin and facilitates the exfoliation of the Horny layers of the epidermis. The chlorophyll contained in nettle, sage and aloe juice, stimulant, tonic effect, increases the metabolism.

The presence of essential amino acids in garlic, walnut, wheat germ oil and tea tree needed to build hair. Using arginine is possible to maintain the normal levels of nitric oxide necessary to increase blood flow in the region of the growth zone of the hair. Vitamin F, found in wheat germ oil and tea tree, prevents hair loss and dandruff.

Organic acids (formic, ascorbic, malic, oxalic and others) and glycosides present in the herb, burdock, nettle, chamomile flowers, calendula, walnut, aloe, leaf sage, fruit lemon, reinforcing the effect of each other, causing a rush of blood to the surface of the skin, increases blood circulation in the capillaries of the skin and in the area of hair follicles. Besides organic acids help to cleanse the skin pores, causing the best SPM is giving nutritional and medicinal compounds. Polysaccharides (walnut) have anti-inflammatory action and improve the protective function of the scalp.

Saponins, steroids and alkaloids contained in the flowers of the calendula, hop cones and leaves of sage, have a tonic effect on metabolic processes, increasing the functional activity of nerve endings, promoting a faster update of the skin tissue, and shorten the rest period" of hair. Vitamin PP (leaf sage, lemon fruit, hops and castor oil, tea tree and wheat germ) is struggling with itching skin and dandruff. The b vitamins In plants such as carrots, garlic, lemon, nettle, hops and castor oils, tea tree and wheat germ, give hair a healthy Shine and a fresh look, increase hair growth, struggling with grey hair, prevent itching and dryness of the scalp and dandruff. Trace elements in plants and spring water are also beneficial in the growth and structure of hair. Mg and CA - improves trophism of the hair follicle, Zn normalizes the functioning of the skin and hair growth, si necessary for the accumulation of keratin, Fe restores hair growth, S and Se help to strengthen hair roots, organic silicon improves metabolism, helps delay CA.

Proteins is regenerating substances, adhesive scales of surface the surface layer of the hair, they prevent split ends, add Shine. Volatile - have antimicrobial and anti-inflammatory action. Proteins and volatile see the grass burdock, walnut, leaf sage, fruits, lemon, carrot, garlic.

Tincture of Cayenne pepper contains capsaicin, which stimulates the circulation in the capillaries of the scalp and restores the metabolic processes in the area of the hair follicle.

When chloroform extraction from plant materials are extracted phospho - and glycolipids /Pat. Of the Russian Federation No. 2040265, a 61 K 35/78, 27.07.95. Bull. No. 21 /. Chloroform extract promotes inclusion of fat-soluble biologically active components of herbs in the bilayer membrane of liposomes, and hydrophilic biologically active components are transferred to the aqueous core of liposomes when they are received using reverse phase. Liposomes possess high biological activity in the delivery of drugs into the cells of the body and restore the lipid composition of cell membranes. Fat-soluble components of liposomes are embedded in the cell membrane, water-soluble components penetrate into the cells of the skin. The liposomes fuse with the cell membrane and gradually release the biologically active components, providing a prolongation of action. Another advantage of phospholipid liposomes is their ability ukral the th barrier function of the scalp.

The implementation of the invention.

Examples of specific performance receiving liposomal concentrate for the treatment and care of dry hair type.

Example 1. Liposomal suspension is prepared by evaporation in reversed phase. Charged to the reactor a solution of phospholipids of natural origin and chloroform extract of medicinal plants. The formation of the lipid vesicles are under vacuum at a temperature of 40±1°C for 2.5 hours to remove the chloroform. A pair of chloroform is cooled in the reflux, are condensed and fed to the extraction of medicinal plants.

In the mixer pour brackish spring water 71,79 wt.% and when the stirrer fall asleep nipazol 0.06 wt.% and nipagin 0.1 wt.%. The mixture is stirred at a temperature of 10-20°With in 10-20 minutes, slowly pour in the suspension of liposomes 20.0 wt.%, the vitamin a of 0.0005 wt.%, tincture of Cayenne pepper to 8.0 wt.%, the dye of 0.0005 wt.% and the perfume of 0.05 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate does not have the necessary biological availability, does not stimulate in the right measure skin blood circulation, it will not have adequate moisturizing effect, not blade antibacterial properties, it is not and eat a pleasant smell.

Example 2. Carried out analogously to example 1, but in the mixer pour brackish spring water 64,62, and when the agitator fall asleep nipazol of 0.08 wt.% and nipagin 0.2 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes to 25.0 wt.%, vitamin a 0.001 wt.%, tincture of Cayenne pepper 10.0 wt.%, the dye of 0.001 wt.% and odorant 0.1 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate has the necessary biological activity, stimulates in the right measure skin blood circulation, has a moisturizing effect. Liposomal concentrate has a pleasant smell, soft and smooth consistency that is easily absorbed.

Example 3. Carried out analogously to example 1, but in the mixer pour brackish spring water 59,40 wt.% and when the stirrer fall asleep nipazol 0.1 wt.% and nipagin 0.3 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes 30.0 wt.%, vitamin And 0.002 wt.%, tincture of Cayenne pepper 10.0 wt.%, dye 0.002 wt.% and the perfume 0.2 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate has the necessary biologists who eskay activity stimulates in the right measure skin blood circulation, has a moisturizing effect. Liposomal concentrate has a pleasant smell, soft and smooth consistency that is easily absorbed.

Example 4. Carried out analogously to example 1, but in the mixer pour brackish spring water 52,15 wt.% and when the stirrer fall asleep nipazol to 0.15 wt.% and nipagin 0.4 wt.%. The mixture is stirred at a temperature of 30-40°C for 30-40 minutes, slowly pour in the suspension of liposomes to 35.0 wt.%, the vitamin a of 0.003 wt.%, tincture of Cayenne pepper to 12.0 wt.%, the dye of 0.003 wt.% and the perfume of 0.3 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate not possess greater biological activity and more moisturizing ability. While increased consumption of raw materials, which is economically disadvantageous. Liposomal concentrate very annoying and causes allergic reactions in people with sensitive scalp, has a strong odor.

To prepare a chloroform extract of dried herbs and chopped herbs burdock, nettle, chamomile, calendula, walnut, aloe, hops, focusof, carrots, sage, lemon and garlic mixed in equal amounts and incubated under a germicidal lamp for 3 hours. Then the MCA is fill in chloroform in the ratio of 1:20, mix and insist in a dark place for 2-3 days. Grass depleted in chloroform extraction, pour a 40%solution of ethyl alcohol for extraction of biologically active components, passing in a water-alcohol fraction.

After extraction, the suspension is stirred and separated supernatant.

Liposomal concentrate has a uniform texture, easily absorbed, does not make hair oily and sticky, has no side effects. It is advisable to apply as a therapeutic and preventive tool. For best effect use one ampoule of not less than 3 times a week for 2 months. It is recommended to repeat the course two times a year. Apply to clean damp or dry hair, rubbing the contents of the bottle directly into the roots of the hair until completely absorbed. Do not rinse after applying to dry and style your hair as desired.

Due to the depth of penetration of biologically active substances into the scalp and hair structure, and prolongirovannomu action effect is achieved with less consumption of cosmetics.

Test Center for cosmetic correction of RAS and in Pyatigorsk State Pharmaceutical Academy on animals and humans have shown that the proposed liposomal concentrate for dry type of alonetogether, has no irritant and allergic action, has a positive effect on strengthening, hydrating and nourishing the hair bags and matrix dry hair, as well as catalytic effect on the sebaceous glands.

The simplicity of the process, the availability and low cost plant materials provide an opportunity to create mass production of efficient domestic medical cosmetics.

The present invention in comparison with the prototype and other known technical solution has the following advantages:

- the provision of therapeutic action on dry hair;

- small consumption of cosmetic products;

exception irritating and allergenic actions;

- preservation of favorable organoleptic properties of the concentrate;

- ecological purity of the concentrate.

Liposomal concentrate for the treatment and care of dry hair type, containing biologically active additive of plant and animal origin, in which he contains a suspension of liposomes from phospholipids and lipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile flowers and calendula, a preservative, glycerin, dye, perfume and water, characterized in that, as a dietary Supplement further the nutrient contains herbal extracts of burdock, walnut, aloe, hops, focusof, fruits, carrots, leaf sage, lemons, garlic, vitamin a, and oils - castor, tea tree and wheat germ, alcohol tincture of Cayenne pepper, preservative - nipagin, nipazol in the following content, wt.%:

The suspension of liposomes containing extracts
herbs burdock, nettle, horsetail, chamomile flowers,
calendula, walnut, aloe, hops,
focusof, lemons, garlic and castor oil,
tea tree and wheat germ25,0-30,0
Vitamin a0,001-0,002
Alcohol tincture of Cayenne pepper12,0-15,0
Glycerin2,5-3,0
Nipaginof 0.2-0.3
Nipazol0,08-0,1
Perfume0,1-0,2
Dye0,001-0,002
The water is brackish spring100



 

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2 tbl

FIELD: medicine, stomatology.

SUBSTANCE: invention proposes an agent for prophylaxis and treatment of dental caries that comprises carrier and active substance wherein carrier is made as a bicomponent system consisting of rubber or rubber-like elastomer eliciting high residual deformation and spherical or approaching to spherical rubber particles or rubber-like polymer eliciting the residual deformation less 0.001% and showing deformation indices 10-25 kg/cm2 at relative elongation 0.1-0.25 and in the ratio of components in the carrier = (30:70)-(85:15) wt.-%, size of particles is 1.0-5.0 mm and wherein active substance involves active sources of fluorine, calcium and phosphate ions. Agent is made as plate, rod or block. Method for prophylaxis and treatment of caries involves chewing the indicated agent with strength providing release of active substance from carrier and maintaining the concentration of calcium and fluorine ions in saliva 10-4 - 10-5 M, respectively, for 5-15 min, not less. Agent and method show high effectiveness in treatment and prophylaxis of caries and comfortable using also.

EFFECT: improved, enhanced and valuable medicinal properties of agent and method.

3 cl, 2 tbl

FIELD: medicinal biotechnology, immunology.

SUBSTANCE: invention relates to producing medicinal biological preparations. Invention relates to a method for enhancing specific activity of immunoglobulins of class G. Method involves freezing immunoglobulin G-containing fractions to temperature from -20°C to -196°C and subjected for gamma-irradiation in doses 5-50 kGr with power of absorbed dose 60-110 Gr/min. method provides elevating the specific activity of immunoglobulin G, increasing titer, avidity and reducing anti-complementary activity.

EFFECT: improved method for elevating activity of antibodies.

3 tbl, 3 dwg, 4 ex

FIELD: medicine, stomatology.

SUBSTANCE: therapy suggested should be performed due to applying a thin layer of 0.1%-butyric estradiol solution followed by a 5-min-long ultrasound treatment of the target surface. The method provides complex therapy and prophylaxis of parodontium diseases due to local substitution hormonotherapy with estradiol-containing solution.

EFFECT: higher efficiency of therapy.

1 ex

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