Liposomal concentrate for treatment and care for hair of fatty type

FIELD: perfume and cosmetic industry, cosmetics.

SUBSTANCE: invention relates to producing agents used in care for hair. The liposomal concentrate used in treatment and care for hair of fatty type comprises biologically active substances of mammalian and/or vegetable origin. The concentrate comprises the liposome suspension prepared from phospholipids and lipids with included chloroform extracts of herbs, red pepper alcoholic tincture and glycerol, and also nipagin and nipasol as preserving agents, and perfume and water wherein components are taken in the definite quantitative content. The concentrate possesses the high biological activity, stimulates cutaneous circulation being without cutaneous-irritant and sensibilizing effects.

EFFECT: improved and valuable properties of concentrate.

4 ex

 

The technical field to which the invention relates.

The invention relates to medicine, in particular to cosmetology, and can be used for the production of liposomal concentrate for treatment and care for oily hair.

The level of technology.

Cosmetics for care of hair must possess not only curative activity, but adequate organoleptic properties. The functional purpose of such funds is in action liposomal concentrate on the scalp for faster hair growth, normalization of regulatory processes in the sebaceous glands and the root system, stabilization and regeneration of the hair structure, the elimination of inflammatory processes in the scalp causing irritation, dryness, flaking, give hair a healthy Shine, elasticity, softness and simultaneously fixing the hairstyle.

The combination of the desired properties necessitates the use in the formulation of cosmetic products of the complex synergy of existing biologically active components.

The most effective recognized the use of biologically active substances derived from plant materials.

Known cosmetic products for hair care, using various plant extracts. One of those cf the of funds contains alcohols of high molecular weight synthetic, polyvinylpyrrolidone, citric acid, formaldehyde, fragrance, water, ether nonionic ethoxylated fatty acids and polyglycerol, cationic surfactants based on Quaternary amines and nonionic emulsifier, L-lecithin from vegetable raw materials, and the composition comprising the extract of coffee gernmany, oil propolis extract and hop extract in the ratio of 1.5:1:1 /autosid. The USSR №1738284, MKI a 61 K 7/06, epubl/. The tool effectively protects hair and scalp from ultraviolet radiation.

Lack of funds is that it has insufficient strengthening and anti-inflammatory effect on the hair and scalp, and also does not eliminate dandruff and itchy scalp. Used in the tool surfactant is harmful to the skin because they irreversibly inhibit the activity of the enzymes of the skin, changing their structure ("twisting" of the molecule). Formalin is used in medicine as a preservative, also creates irritant effect denaturised proteins and enzymes of the skin and violates in some degree the normal functioning of the cellular system of the skin.

You know the way to care for your hair after washing, emulsifier, biologically active additive, an acid, a preservative, a perfume, water, emulsifier introduced hakuraa, as a dietary Supplement, glisten and comp the position of hydro-alcoholic extracts of the roots of Rhodiola rosea and nettle or the fruit of the quince or Rowan /Pat. RU # 2025118, a 61 K 7/06, 30.12.1994, bull. No. 27/.

The proposed tool was created with the aim of improving the hair structure and restore the hair surface, i.e. the normalization of the scaly layer (cuticle) of the hair under adverse impacts on the hair shaft and its various injuries.

As a structural component in the composition of the funds introduced hakuraa, waxy substance. This complex, including emulsifying base, Quaternary ammonium compounds, antistatic agent and vegetable proteins with greater affinity to the skin.

Biologically active additive combination Giustina source of vegetable protein, essential for the normal functioning of the skin of the scalp, and composition of plant extracts - roots radioi pink and nettle or the fruit of the quince or ash. Composition of plants is made in such a way that the glycosides, flavonoids, minerals and organic acids of Rhodiola rosea are synergistic active complex with vitamin source - nettles, quince or Rowan. Together they have a tonic, soothing and nourishing effect on the scalp and hair shaft, and the complex of plant protein, Proline, glycine, serine, phenylalanine, leucine, and asparginase and glue the amino acids and other creates a protective amino acid microfilm on the surface layer of the hair.

The disadvantage is lack of firming and anti-inflammatory remedies for hair care, the emphasis on improving the recovery of the structure of the stem part of the hair, while effective on the scalp missing. This composition does not eliminate dandruff and itching, does not have sufficient penetrating power into the scalp.

Famous balm for the hair, comprising, as a biologically active additive mixture of water and alcohol extracts of medicinal herbs chamomile, succession, plantain and nettle, as oil components balm contains oil extracts of thyme or pine or chamomile and further comprises nipagin and water. According to the invention a mixture of water and alcohol extracts of medicinal plants further comprises a water-alcoholic extracts of herbs St. John's wort herb celandine grass knotweed, thyme herb, horsetail grass, cumin seeds, roots of Rhaponticum, leaves mother and stepmother, yarrow, marjoram, growths of the fungus birch, elderberry fruit, grass, clover, bilberry fruit, grass, shrubby cinquefoil, peppermint leaves, calendula flowers, herbs motherwort, cowberry leaf, birch leaves, rhizomes with roots of Valais is any, grass cudweed herb swamp, juniper berries, root cinquefoil, burdock root, root of peony, herb termopsis and leaves of bearberry /Pat. Of the Russian Federation No. 2153323, a 61 K 7/48, epubl g/.

The positive properties of the balm is the presence of a large number of different herbal ingredients that improve metabolic function in the growth zone of the roots of the hair, strengthening volosjanyj follicles and make the hair a healthy look and Shine. Organic acids increase blood circulation in the capillaries of the skin and in the area of hair follicles. Carotenoids, flavonoids and tannins are antioxidants. Flavonoids improve the elasticity of skin tissue and the capillary walls. Vitamins nourish and accelerate the regeneration processes in the skin and hair roots. The absence of irritating components is a positive property in the recipe balm.

The disadvantage balm is not sufficiently deep penetration of the biologically active components in the structure of skin and hair, the short duration of their impact.

The closest in technical essence and the achieved positive effect and that we have adopted for the prototype is hair gel, containing biologically active additive of plant and animal origin, gel-forming components, a preservative, a perfume and water ocimene is, at the same time as biologically active additives it contains a suspension of liposomes from phospholipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile, Hypericum and calendula, as a gelling component - ammonium salt Recoletos copolymer of acrylic acid and polyallylamine esters of pentaerythritol, as preservative methyl and propyl esters of peroxybenzoyl acid and further comprises glycerin, paraform and dye at the following content, wt.%:

The suspension of liposomes8,0-10,0
Glycerin2,5-3,0
Methyl ester paraoccupational acidof 0.2-0.3
Propyl ester paraoccupational acid0,08-0,1
Paraform0,02-0,03
Ammonium salt of Recoletos
copolymer of acrylic acid and
polyallylamine esters of pentaerythritol0,8-1,0
Perfume0,1-0,2
Dye0,001-0,002
WaterRest

(see Pat of the Russian Federation No. 2150267, class a 61 K 7/06, epubl).

<> The disadvantage of this hair gel is a low concentration of biologically active substances and inadequate provision of therapeutic action on oily hair.

Disclosure of the invention.

Object of the present invention is to provide a therapeutic liposomal concentrate for oily hair with prolongation of action of biologically active components, while maintaining favorable organoleptic properties of the concentrate.

Oily hair are at increased activity of the sebaceous glands on the scalp, which are different. For oily hair fat content in the skin of the scalp of excess.

The technical result that can be achieved using the present invention is to provide therapeutic and cosmetic effect on oily hair by increasing the concentration of biologically active components creation of phyto compositions, as well as the selection of the composition, affecting the solubility of fat, remove excess sebum and inhibition of sebaceous glands, preserving favorable organoleptic properties of the concentrate and reduce its value.

The technical result is achieved by liposomal concentrate for oily hair, containing biologically active additives of animal and/or vegetable origin is to be placed, which contains a suspension of liposomes from phospholipids and lipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile flowers and calendula, a preservative, glycerin, dye, perfume and water, this dietary Supplement also contains herbal extracts of burdock, horsetail, Linden, hop cones, grape seed extract, onion, lemons, vitamin a, and oils of tea tree and wheat germ, the alcoholic tincture of Cayenne pepper, glycerin, preservative - nipagin, nipazol, perfume, dye and water spring brackish at the following content, wt.%:

The suspension of liposomes containing
the herbal extracts of burdock, nettle, horsetail,
chamomile flowers, calendula, Linden,
of hops, extract of grape
seeds, onion seeds, fruits
lemon, tea tree oil
wheat germ25,0-30,0
Vitamin a0,001-0,002
Alcohol tincture of pepper Struchkova the 12,0-15,0
Glycerin2,5-3,0
Nipaginof 0.2-0.3
Nipazol0,08-0,1
Perfume0,1-0,2
Dye0,001-0,002
The water is brackish springUp to 100%

The entity receiving liposomal concentrate for treatment and care for oily hair is the following. Liposomal suspension is prepared by evaporation in reversed phase. Charged to the reactor a solution of phospholipids of natural origin and chloroform extract of medicinal plants. The formation of the lipid vesicles are under vacuum at a temperature of 40±1°C for 2.5 hours to remove the chloroform. A pair of chloroform is cooled in the reflux, are condensed and fed to the extraction of medicinal plants.

In the mixer pour brackish spring water 64,62-59,40 wt.% and when the stirrer fall asleep nipazol 0.08 to 0.1 wt.% and nipagin of 0.2-0.3 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes of 25.0-30.0 wt.%, vitamin a 0.001 0.002 wt.%, tincture of Cayenne pepper 10.0 wt.%, dye 0,001-0,002% by weight and the perfume of 0.1-0.2 wt.%. Ready liposomal to Central Packed in sterile ampoules or plastic bottles.

To prepare a chloroform extract of dried herbs and chopped herbs burdock, nettle, chamomile, calendula, walnut, aloe, hops, focusof, carrots, sage, lemon and garlic mixed in equal amounts and incubated under a germicidal lamp for 3 hours. The mixture is then poured chloroform in the ratio of 1:20, mix and insist in a dark place for 2-3 days. Grass depleted in chloroform extraction, pour a 40%solution of ethyl alcohol for extraction of biologically active components, passing in a water-alcohol fraction.

After extraction, the suspension is stirred and separated supernatant.

As a result of research for selecting the optimal concentration of all components of the liposomal concentrate for the treatment and care of dry hair type, we have determined that a decrease in the concentration of botanicals less than 10 wt.% reduces the biological activity of the finished product, the increase in the concentration of botanicals above 15 wt.% not advisable, since the biological activity does not increase, while increased consumption of raw materials, that is, it is not economically viable. The decrease in the concentration of the alcoholic tincture of Cayenne pepper less than 10 wt.% does not stimulate in the right measure skin blood circulation, and increase concentric is above 10 wt.% much irritating to the scalp, not suitable for people with sensitive scalp and may cause allergic reactions. The decrease in the concentration of glycerol below 2.5 wt.% leads to a decrease moisturizing effect of liposomal concentrate, increase higher than 3.0 wt.% not economically expedient, as the moisturizing effect is not changed. The decrease in the concentration of nipagin below 0.2 wt.% reduces the bactericidal properties of the finished product, and increasing the concentration above 0.3 wt.% causes irritation of the scalp. The decrease in the concentration nipazola below 0.08 wt.% reduces the bactericidal properties of the finished product, and the increase in concentrations above 0.1 wt.% causes irritation of the scalp. The decrease in the concentration of odorants less than 0.1 wt.% does not need a pleasant aroma to the finished product, and increasing the concentration above 0.2 wt.% causes scalp irritation and allergic reactions. The decrease in the concentration of dye is lower than 0.001 wt.% does not the finished product of the required color, and the increase in the concentration of dye above 0.002 wt.% causes scalp irritation and allergic reactions. As for the temperature, then reducing it below the 20°slows the reaction rate and increases the cooking time of the finished product, while increasing the temperature more than 30°not valid since may prosout the destruction of liposomes. When reducing mixing time less than 20 minutes is not achieved uniformity of mass, increase mixing time associated with the consumption of electricity, which is not advisable from the point of view of economy.

Thus, the ratio of the components of liposomal concentrate for treatment and care for oily hair optimally and achieve the desired effect.

Liposomal concentrate towards the prototype has the following positive aspects.

Use as biologically active additives to the suspension of liposomes from phospholipids and lipids of animal and/or vegetable origin include chloroform extracts of ten herbs: burdock, nettle, horsetail, chamomile flowers, calendula, Linden, hop cones, grape seed extract, onion, lemons, vitamin a oils of tea tree and wheat germ.

Introduction to the formulation of additional botanicals, as well as the use of vegetable oils and tinctures pepper increases the concentration of biologically active substances included in the liposomal concentrate, due to which the claimed formulation is used as a prophylactic and therapeutic agent.

The extract of these herbs includes over a full range of biologically active components necessary Kandla hair roots, and rods. It contains carotenoids, Tocopherols and flavonoids contained in the grass burdock, nettle, horsetail, chamomile flowers, calendula, Linden, cones of hops, grape seed extract, onions, which have antioxidant properties, inhibiting the formation of excessive amounts of peroxide compounds, corroding cell membranes in the scalp. In addition, these compounds possess anti-inflammatory, capillary, desensitizing effect. Regulate lipid, mineral, water exchanges, the regeneration of the epidermis of the skin, improve the activity of hair follicles, have bactericidal and fungicidal properties, have estrogenic activity. Together with ascorbic acid, flavonoids are involved in redox processes, which improves cell respiration scalp, increasing the absorption of oxygen skin tissues.

Azulene, sesquiterpenoid in the grass burdock, chamomile flowers, calendula, Linden, hop cones, onions, oils of tea tree and wheat germ, anti-inflammatory and antiallergic effect, thereby reducing the irritation of the scalp, helping to reduce the formation of dandruff. Essential oils have a tonic effect on the metabolic process is si. The presence of unsaturated fatty acids and their triglycerides in the grass burdock, chamomile flowers, calendula, onions, grape seed extract, promotes nutrition and elimination of vitamin a deficiency, in addition, unsaturated fatty acids improve lipid metabolism in the tissues of the skin and promote the exfoliation of the Horny layers of the epidermis. The chlorophyll contained in nettle, stimulant, tonic effect, increases the metabolism.

The presence of essential amino acids in the horsetail herb, grape seed extract and oils of tea tree and wheat germ is needed to build hair. Using arginine is possible to maintain the normal levels of nitric oxide necessary to increase blood flow in the region of the growth zone of the hair. Vitamin F, present in grape seed extract, oils of tea tree and wheat germ, prevents hair loss and dandruff.

Organic acids (formic, ascorbic, malic, oxalic and others) and glycosides contained in the grass burdock, nettle, chamomile flowers, calendula, grape seed extract, fruit lemon, reinforcing the effect of each other, causing a rush of blood to the surface of the skin, increases blood circulation in the capillaries of the skin and in the area of hair follicles. Besides organic acids contribute about is isenia skin pores, determining the best absorption of nutrients and medicinal compounds. Polysaccharides (horsetail herb) have anti-inflammatory action and improve the protective function of the scalp.

Saponins, steroids and alkaloids in the herb, horsetail herb, flowers, Linden, marigold, hop cones, have a tonic effect on metabolic processes, increasing the functional activity of nerve endings, promoting a faster update of the skin tissue of the head and shorten the rest period" of hair. Vitamin PP (onions, lemons, grape seed extract, tea tree oil and wheat germ) is struggling with itching skin and dandruff. B vitamins such plants as carrots, onions, lemon, grapes, nettle, hops and oils of tea tree and wheat germ - give hair a healthy Shine and a fresh look, increase hair growth, struggling with grey hair, prevent itching and dryness of the scalp and dandruff. Trace elements in plants and spring water are also beneficial in the growth and structure of hair. Mg and CA improves trophism of the hair follicle, Zn normalizes the functioning of the skin and hair growth, Cu is required for the accumulation of keratin, Fe restores hair growth, S and Se help to strengthen hair roots, organic silicon improves metabolism and promotes C is the support of the Sa.

Proteins is regenerating substances, adhesive scales of the surface layer of the hair, they prevent split ends, add Shine. Volatile - have antimicrobial and anti-inflammatory action. Proteins and volatile see the grass burdock, onions, fruits, lemon and carrot.

Tincture of Cayenne pepper contains capsaicin, which stimulates the circulation in the capillaries of the scalp and restores the metabolic processes in the area of the hair follicle.

When chloroform extraction from plant materials are extracted phospho - and glycolipids /Pat. Of the Russian Federation No. 2040265, a 61 K 35/78, 27.07.95, bull. No. 21 /. Chloroform extract promotes inclusion of fat-soluble biologically active components of herbs in the bilayer membrane of liposomes, and hydrophilic biologically active components are transferred to the aqueous core of liposomes when they are received using reverse phase. Liposomes possess high biological activity in the delivery of drugs into the cells of the body and restore the lipid composition of cell membranes. Fat-soluble components of liposomes are embedded in the cell membrane, water-soluble components penetrate into the cells of the skin. The liposomes fuse with the cell membrane and gradually release the biologically active components, providing a prolongation of action. Eseade the advantage of phospholipid liposomes - it is their ability to strengthen the skin's barrier function of the head.

The implementation of the invention.

Examples of specific performance receiving liposomal

concentrate for treatment and care for oily hair.

Example 1. Liposomal suspension is prepared by evaporation in reversed phase. Charged to the reactor a solution of phospholipids of natural origin and chloroform extract of medicinal plants. The formation of the lipid vesicles are under vacuum at a temperature of 40±1°C for 2.5 hours to remove the chloroform. A pair of chloroform is cooled in the reflux, are condensed and fed to the extraction of medicinal plants.

In the mixer pour brackish spring water 71,79 wt.% and when the stirrer fall asleep nipazol 0.06 wt.% and nipagin 0.1 wt.%. The mixture is stirred at a temperature of 10-20°C for 10-20 minutes, slowly pour in the suspension of liposomes 20.0 wt.%, the vitamin a of 0.0005 wt.%, tincture of Cayenne pepper to 8.0 wt.%, the dye of 0.0005 wt.% and the perfume of 0.05 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate does not have the necessary biological availability, does not stimulate in the right measure skin blood circulation, it will not have adequate wlasnego effect, not has antibacterial properties, it does not have a pleasant smell.

Example 2. Carried out analogously to example 1, but in the mixer pour brackish spring water 64,62, and when the agitator fall asleep nipazol of 0.08 wt.% and nipagin 0.2 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes to 25.0 wt.%, vitamin a 0.001 wt.%, tincture of Cayenne pepper 10.0 wt.%, the dye of 0.001 wt.% and odorant 0.1 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate has the necessary biological activity, stimulates in the right measure skin blood circulation, has a moisturizing effect. Liposomal concentrate has a pleasant smell, soft and smooth consistency that is easily absorbed.

Example 3. Carried out analogously to example 1, but in the mixer pour brackish spring water 59,40 wt.% and when the stirrer fall asleep nipazol 0.1 wt.% and nipagin 0.3 wt.%. The mixture is stirred at a temperature of 20-30°C for 20-30 minutes, slowly pour in the suspension of liposomes 30.0 wt.%, vitamin And 0.002 wt.%, tincture of Cayenne pepper 10.0 wt.%, dye 0.002 wt.% and the perfume 0.2 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

The result is at: received liposomal concentrate has the necessary biological activity, stimulates in the right measure skin blood circulation, has a moisturizing effect. Liposomal concentrate has a pleasant smell, soft and smooth consistency that is easily absorbed.

Example 4. Carried out similarly to example 1, but in the mixer pour brackish spring water 52,15 wt.% and when the stirrer fall asleep nipazol to 0.15 wt.% and nipagin 0.4 wt.%. The mixture is stirred at a temperature of 30-40°C for 30-40 minutes, slowly pour in the suspension of liposomes to 35.0 wt.%, the vitamin a of 0.003 wt.%, tincture of Cayenne pepper to 12.0 wt.%, the dye of 0.003 wt.% and the perfume of 0.3 wt.%. Ready liposomal concentrate Packed in sterile ampoules or plastic bottles.

Result: received liposomal concentrate not possess greater biological activity and more moisturizing ability. While increased consumption of raw materials, which is economically disadvantageous. Liposomal concentrate very annoying and causes allergic reactions in people with sensitive scalp, has a strong odor.

To prepare a chloroform extract of dried herbs and chopped herbs burdock, nettle, horsetail, chamomile flowers, calendula, Linden, hop cones, grape seed extract, onion, lemons mixed in equal amounts and incubated under a germicidal lamp in those who tell 3 hours. The mixture is then poured chloroform in the ratio of 1:20, mix and insist in a dark place for 2-3 days. Grass depleted chloroform extraction pour a 40%solution of ethyl alcohol for the extraction of biologically active components moving in the water-alcohol fraction.

After extraction, the suspension is stirred and separated supernatant.

The ratio of all components of the liposomal concentrate for oily hair optimally and achieve the desired effect.

Liposomal concentrate has a uniform texture, easily absorbed, does not make hair oily and sticky, has no side effects. It is advisable to apply as a therapeutic and preventive tool. For best effect use one ampoule of not less than 3 times a week for 2 months. It is recommended to repeat the course two times a year. Apply to clean damp or dry hair, rubbing the contents of the bottle directly into the roots of the hair until completely absorbed. Do not rinse after applying to dry and style your hair as desired.

Due to the depth of penetration of biologically active substances into the scalp and hair structure, and prolongirovannomu action effect is achieved with less consumption of cosmetics.

Testing in General is tre cosmetic correction of RAS and in Pyatigorsk State Pharmaceutical Academy on animals and humans have shown the proposed liposomal concentrate for oily hair type is nontoxic, has no irritant and allergic action, has a positive effect on strengthening, hydrating and nourishing the hair bags and matrix dry hair, as well as inhibitory effect on the sebaceous glands.

The simplicity of the process, the availability and low price of vegetable raw materials gives you the ability to create mass production of efficient domestic medical cosmetics.

The present invention in comparison with the prototype and other known technical solution has the following advantages:

- the provision of therapeutic action on oily hair;

- small consumption of cosmetic products;

exception irritating and allergenic actions;

- preservation of favorable organoleptic properties of the concentrate;

- ecological purity of the concentrate.

Liposomal concentrate for treatment and care for oily hair, containing biologically active additives of animal and/or vegetable origin, in which he contains a suspension of liposomes from phospholipids and lipids of animal and/or vegetable origin include them chloroformic extracts of nettle, chamomile and calendula, a preservative, glycerin, dye, CTD is the Cabinet and the water, characterized in that the biologically active additive additionally contains herbal extracts of burdock, horsetail, Linden, hop cones, grape seed extract, onion, lemons, vitamin a, as well as tea tree oil and wheat germ, the alcoholic tincture of Cayenne pepper, glycerin, preservative - nipagin, nipazol in the following content, wt.%:

The suspension of liposomes containing extracts
herbs burdock, nettle, horsetail, chamomile,
calendula, Linden, hop cones, extract
grape seed, onion,
fruit lemon, tea tree oil
wheat germ25,0-30,0
Vitamin a0,001-0,002
Alcohol tincture of Cayenne pepper12,0-15,0
Glycerin2,5-3,0
Nipaginof 0.2-0.3
Nipazol0,08-0,1
Perfume0,1-0,2
Dye0,001-0,002
The water is brackish spring100



 

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1 dwg

FIELD: medicine, infectious diseases.

SUBSTANCE: method involves administration of electroactivated aqueous solutions of salts with negative and positive redox-potential and definite pH value and with the concentration of active chlorine in the definite sequence and regimen. Invention promotes to arresting basic pathogenetic syndromes of disease due to normalization of metabolic processes in body and recovery of the normal microbiocenosis and by development of conditions promoting to using the own natural potential by human. Invention can be used for complex treatment of parasitic and infectious diseases.

EFFECT: improved method for treatment.

3 cl, 4 ex

FIELD: experimental medicine, immunology.

SUBSTANCE: invention relates to a method for immunization of intact animals with ram erythrocytes treated by alternating magnetic field 50 Hz and 25 mTl for 30 min. Method provides enhancement of induction of the primary immune response in experimental animals. Invention can be used for stimulation of immune response in experiment.

EFFECT: improved method for stimulating.

2 tbl

FIELD: medicine, stomatology.

SUBSTANCE: invention proposes an agent for prophylaxis and treatment of dental caries that comprises carrier and active substance wherein carrier is made as a bicomponent system consisting of rubber or rubber-like elastomer eliciting high residual deformation and spherical or approaching to spherical rubber particles or rubber-like polymer eliciting the residual deformation less 0.001% and showing deformation indices 10-25 kg/cm2 at relative elongation 0.1-0.25 and in the ratio of components in the carrier = (30:70)-(85:15) wt.-%, size of particles is 1.0-5.0 mm and wherein active substance involves active sources of fluorine, calcium and phosphate ions. Agent is made as plate, rod or block. Method for prophylaxis and treatment of caries involves chewing the indicated agent with strength providing release of active substance from carrier and maintaining the concentration of calcium and fluorine ions in saliva 10-4 - 10-5 M, respectively, for 5-15 min, not less. Agent and method show high effectiveness in treatment and prophylaxis of caries and comfortable using also.

EFFECT: improved, enhanced and valuable medicinal properties of agent and method.

3 cl, 2 tbl

FIELD: medicinal biotechnology, immunology.

SUBSTANCE: invention relates to producing medicinal biological preparations. Invention relates to a method for enhancing specific activity of immunoglobulins of class G. Method involves freezing immunoglobulin G-containing fractions to temperature from -20°C to -196°C and subjected for gamma-irradiation in doses 5-50 kGr with power of absorbed dose 60-110 Gr/min. method provides elevating the specific activity of immunoglobulin G, increasing titer, avidity and reducing anti-complementary activity.

EFFECT: improved method for elevating activity of antibodies.

3 tbl, 3 dwg, 4 ex

FIELD: medicine, stomatology.

SUBSTANCE: therapy suggested should be performed due to applying a thin layer of 0.1%-butyric estradiol solution followed by a 5-min-long ultrasound treatment of the target surface. The method provides complex therapy and prophylaxis of parodontium diseases due to local substitution hormonotherapy with estradiol-containing solution.

EFFECT: higher efficiency of therapy.

1 ex

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