Method for correcting hormonal and immune disorders in patients with hormonodependent diseases

FIELD: medicine, gynecology.

SUBSTANCE: patients should be suggested to take radon procedures as baths, gynecolopgical irrigations, microenemas, laserotherapy in autoresonance mode at altering frequency of laser apparatus independently against frequency characteristics of human body, at wave length of 0.89 mcm, power of 10 W onto area of uterine projection in case of genital endometriosis and uterine myoma at exposure of 15 min and onto mammary glands in case of diffuse proliferative mastopathies. Impact fields should be chosen by sectors ranged 10-16 per 10-15 sec for each impact field. Local therapy should be conducted about 2.5-3 h after taking radon procedures successively, not earlier. The first stage - baths with malavit at 1:5 dilution at exposure of 15 min. The second stage - after removing the solution out of vagina it is necessary to introduce malavit gel at a tampon for 4-6 h. The whole therapy should be carried out together with internal intake of mineral water 30-60 min before meals thrice daily per 3.5 mg/kg body weight. The innovation enables to achieve prolonged remission, normalize hormonal level in blood and duration of the second phase of the cycle and decrease cholesterol level in blood.

EFFECT: higher efficiency of correction.

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The invention relates to medicine, namely to the gynecologist, and for the treatment of women suffering from hormone-dependent gynecological diseases.

Known methods of treatment of women suffering from hormone related diseases (genital endometriosis, uterine fibroids, diffuse mastopathy) using radon water in the form of baths, gynecological irrigation, microenemas (Ifertility, Escobares, Nvelo 1985; Lpoa, Waguri, Bgerman, MSW, Abousamra: "Differentiated methods of health resort treatment of patients with genital endometriosis and kraurosis vulva", 1995; Abousamra, Eva: "Change of immunogenesis when radon in patients with genital endometriosis". Balneology and physiotherapy of Siberia in the concept of development of health and medical science of the Russian Federation. Materials of scientific conference. - Tomsk, 2002; Abousamra, Eva: "the Influence of radon water on the hormonal balance in genital endometriosis" - proceedings of the VII International forum 21-28 April 2002 - Tunisia, Hammamet. - Moscow, 2002), radon water in combination with EHF-therapy (WAV, Abousamra: "the Use of EHF-therapy in the resort rehabilitation of patients with genital endometriosis and kraurosis vulva", 2000) and radon water in combination with laser therapy locally on the areas of projection of the uterus, the ovaries, and mammary glands (A.B. Ovsienko: "non-drug therapy genital endometriosis" - Materials of International scientific-practical conference "UNIVERSITY. Health. Intelligence". - Kislovodsk, 2003).

These treatments have a positive effect on the hormonal and immune status (reduction of initial elevated levels of estrogen and increase reduced the concentration of progesterone, immunomodulatory or immunostimulatory in some cases the influence). Structure of body tissues and cervical cancer, breast cancer is improving: reduced size of foci of tumor processes. However, when assessing the immediate results of complex redone - and laser therapy draws attention to the increased levels of cholesterol and atherogenic factor in 65% of patients, and the analysis of remote results of treatment it should be noted that the concentration of progesterone in 78% of patients remains quite high at low values of estradiol. The set of factors in addition to positive aspects leads to a marked vascular spasm, including in target organs, which indirectly can contribute to the blocking of the receptor for sex steroid hormones and long-term causes resumption of pathological manifestations in one way or another. Thus, being essentially pathogenetic therapy hormone is awesime gynecological diseases, complex redone - and laser therapy are not affected at all stages of pathogenesis of these processes.

The essence of the invention lies in the fact that patients prescribed radon treatment in the form of baths, gynecological irrigation, microenemas, laser therapy on the area of projection of the uterus and / or mammary glands in combination with internal mineral water and local treatment consists in the use of trays with malavita and tampons with gel Malawi. Apply radon baths, gynecological irrigation, microclysters with a radon concentration of 1.5 or 6.5 BCF/l, with each exposure radon process 15 minutes in a course of 10 treatments; no earlier than 2 hours after receiving radon procedures or in interleaving with radon treatments a day is prescribed laser therapy in autoresonance mode with variable frequency laser apparatus (regardless of frequency characteristics of the human body). The wavelength of 0.89 μm, frequency mode - autoresonance, power - 10 watts, for 10-15 seconds on each field effects. Field effects are chosen depending on the nature of hormone-dependent gynecological diseases and layout area of the pathological process. In genital endometriosis and uterine myoma (without gross structural changes of the nodes and in the absence of Express predominance of Feb the religious component by ultrasound) the scope of the impact of laser radiation gynecological area (the projection of the body of the uterus) without capture of the projection area of the ovaries. In the diffuse mastopathy lasertherapeutics the sectoral impact is depending on the volume of the breast, from 10 to 16 fields of influence. The emitter is installed on another field with the touch of a field, the motion of the emitter as the impact is clockwise and radiare. On the nipple and areola laser treatment is not provided.

For internal reception of mineral water use of carbon dioxide chloride-hydrocarbonate-sulphate-sodium-calcium water warm Narzanov sources N4, N7 and N24, 3.4 mg per 1 kg of body weight 3 times a day, for 40 minutes before a meal. These waters are characterized by high saturation, hypotonic concentration of salts (5,2 g/l), therapeutically active concentration of iron, more than 10 mg/l (ISTC, N24) and silicon (.N24), high content of heavy metals (.N4, N7, N24), manganese, potassium and thorium X (.N7). The content of the latter can be attributed to the source N7 (hepatosis) to slightly radioactive water with a high content of thorium X.

For local procedures use malavit in the form of a solution or gel: the solution malavita in a dilution of 1:5 - baths, standard gel malavit for vaginal swabs. The choice of drug substances (Malawi) is associated with its pH is Yami. Malawi normalizes vaginal biocenosis, increasing the number of sticks Doderlein, is the information of the active drug. Along with powerful antiseptic antibacterial, strong antiviral, antifungal activities, it has the ability to regulate the recovery of the cells of the body through the skin, mucous membranes, biologically active substances and nerve endings. Malawi improves the conduction of nerve impulses in the Central and peripheral nervous system. These particular effects contribute to the restoration of the normal structure of cells, tissues organs.

The method is performed as follows.

Patients prescribed radon baths, gynecological irrigation, microclysters with a radon concentration of 1.5 or 6.5 BCF/l, with each exposure radon treatments 15 minutes, at the rate of 10 treatments. Procedures patients receive mode: 2-3 days reception - 1 day break. Not earlier than in 2 hours after receiving radon procedures or in interleaving with radon treatments a day is prescribed laser therapy. The wavelength of 0.89 μm, frequency mode - autoresonance, power of 10 W, for 10-15 seconds on each field effects. Field effects are selected depending on the hormone dependent diseases: in genital endometriosis and fibroids mA is key the area of the projection of the body of the uterus, when breast - sectoral depending on the volume of the breast, from 10 to 16 fields of influence. The emitter is installed on another field effects with the touch of a field, when genital endometriosis and uterine myoma, the impact is within 15 minutes on the area of projection of the uterus, mastitis movement of the emitter is clockwise and radiare. On the nipple and areola laser treatment is not provided. Local treatment in the form of trays with malavita and tampons with gel Malawi is carried out not earlier than 2.5-3 hours after ingestion of radon procedures and implemented consistently. The first stage baths with malavita in a dilution of 1:5 with exposure time of 15 minutes, the second stage - after removal from the vagina of a solution is injected gel Malawi on the swab for 4-6 hours. Internal intake of mineral water is provided daily, 30-60 minutes before meals, depending on the state of the hepatobiliary system, in the amount of 3.5 mg/kg of body weight 3 times a day.

The method is illustrated by the following examples

Example 1. Patient L. Ponomarenko. Diagnosis: Diffuse mastopathy, genital endometriosis. Complaints of pain during menstruation, pain in the breast that occur before and during menstruation, often not related to the cycle, chromazone before menstruation. Bimanual examination of the determined increase in the uterus up to 4-5 weeks., the body of the uterus heterogeneous texture, with a slightly rough surface, painful on palpation; seals and inhomogeneous rough education sacral uterine ligaments. During the inspection and palpation of the mammary glands - multiple painful diffuse foci of seals in the upper quadrants of both Breasts, more to the right. Nipple discharge was not. Studies: clinical blood and urine tests - without a pathology. ECG - without features. In the study of hormones in the blood was determined by the increased values of estradiol (318,3 PG/ml) and decreased levels of progesterone (4.6 nmol/l). Immunological studies have revealed violations of cellular immunity (excess levels of b-lymphocytes and a decrease in T-helper cells), disorders of phagocytic activity and decreased levels of immunoglobulins. According to the lipid cholesterol was increased to 6.9 mmol/l, HDL-C was 1,97 mm/l and LDL - 2,63 mm/l haemoglobin rate was also increased. An ultrasound of the genital organs was determined by multiple echopositive polymorphic inclusions with irregular contours in the myometrium different parts of the body of the uterus, endometrial thickness 11 mm (examination - in the second phase of the cycle). When breast ultrasound were registered multiple diffuse located lots of inclusions at the top is external, the upper inner quadrants. When corporateregister.com study indicated prolonged increase KPI (up to the 18th day of the cycle), the right shift in the maturation index (IP) with a predominance of superficial cells up to the 17th day of the cycle.

Treatment. The complex treatment consisted of appointment total radon baths, gynecological radon irrigation and microenemas of radon water (200,0) drip method temperature 36°With, exposure time 15 min, the concentration of radon water 180 NCI/l (6,5 kBq/l). All procedures were performed in one day, 2-3 days in a row, a break of 1 day, a course of 10 treatments.

After receiving the specified complex treatment decreased pain in the abdomen and mammary glands, palpation, pain, lesions of endometriosis and diffuse thickening in the breast, the prevalence of pathological formations. Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal flora - II. ECG - without features. Estradiol levels decreased (276,4 PG/ml)and progesterone increased (by 6.9 nmol/l). Immunological studies level b-lymphocytes, T-helpers, indicators phagocytic activity and immunoglobulins increased. According to the lipid cholesterol increased to 7.2 mmol/l, HDL dropped slightly to a 1.88 mmol/l and LDL increased to 2.89 mm/l haemoglobin rate is stavilsya increased. An ultrasound of the genital organs was determined by the improved structure of the myometrium (generally fewer ekopozytywny polymorphic impurities, smooth the contours of inclusions, reducing the size of the source is increased uterine body). When breast ultrasound lots of inclusions in the upper outer, upper inner quadrants decreased in size. When corporateregister.com study continued improvement of the CRPD to 11 day cycle, offset to the left in the maturation index (IP) with increasing number of intermediate cells up to 12 day cycle.

The patient was discharged with improvement of the General condition, gynecological status, mammary glands; after 1 year re-examined in the clinic. Clinical status, physical examination and palpation, ultrasound examination of the genitals and mammary glands has somewhat deteriorated in comparison with the status after the course of therapy, but still the size of the foci of pathological changes in tissues is not reached. The patient notes a growing pain in the abdomen and mammary glands during the last 3 months. Studies of hormones in the blood concentration of estradiol was 291,4 PG/ml and progesterone - 5.6 nmol/L. Significant changes of the immunological background in comparison with the status after the course of therapy were not found.

Summary. Thus, the patient received in the clinic treatment radon, endured the procedure well, negative side effects were not. Observed remission for 9 months.

Example 2. Sick of Sigaeva REVEALED the Diagnosis of Diffuse mastopathy, genital endometriosis. Complaints of lower abdominal pain in mammary glands that occur before and during menstruation, often not related to the cycle, pain during menstruation, chromazone before menstruation. Bimanual examination - an increase in the uterus up to 5-6 weeks., the body of the uterus heterogeneous consistency, with a rough surface, painful on palpation. During the inspection and palpation of the mammary glands, painful diffuse foci of seals in the upper quadrants of both Breasts, more to the right. Nipple discharge was not. During examination: clinical blood and urine tests - without a pathology, ECG - without features. In the study of hormones in the blood was determined by the increased values of estradiol (294,6 PG/ml) and decreased levels of progesterone (3.9 nmol/l). Immunological studies have revealed violations of cellular immunity (excess levels of b-lymphocytes), minor violations of phagocytic activity and content of immunoglobulins. According to the lipid cholesterol was within normal limits - 5.6 mm/l, HDL-C was 1,91 mm/l and LDL - 3,13 mm/l Ratio at which ravennati was slightly elevated. An ultrasound of the genital organs was determined by multiple echopositive polymorphic inclusions with irregular contours around the myometrium. When breast ultrasound - multiple diffuse located lots of inclusions in the upper outer, upper inner quadrants. When corporateregister.com study indicated prolonged increase KPI (up to 17 day cycle), offset to the right IP with a predominance of surface cells to 17 day cycle.

Treatment. The complex treatment consisted of destination gynecological radon irrigation, General radon baths and microenemas of radon water (200,0) drip method, the exposure time is 15 minutes, the temperature - 36°C. Used radon water concentration 180 NCI/l (6,5 kBq/l). All procedures were performed in one day, 2-3 days in a row, a break of 1 day, a course of 10 treatments. 2 hours after receipt of radon procedures or in interleaving with radon treatments a day was prescribed laser therapy. The wavelength of 0.89 μm, frequency mode - autoresonance, power of 10 W, for 10-15 seconds on each field effects. Field effects are selected depending on the hormone dependent diseases: in genital endometriosis and uterine fibroids - area projection of the body of the uterus, when breast - sectoral depending on the volume of the breast, from 10 to 6 fields of influence. The emitter is installed on another field effects with the touch of a field, when genital endometriosis and uterine myoma, the impact is within 15 minutes on the area of projection of the uterus, mastitis movement of the emitter is clockwise and radiare. On the nipple and areola laser treatment is not provided. Not earlier than 2.5-3 hours after ingestion of radon procedures consistently carried out by local treatment in the form of trays with malavita and tampons with gel malawati drinking of mineral water were carried out daily, 30-60 minutes before meals, depending on the state of the hepatobiliary system, in the amount of 3.5 mg/kg of body weight 3 times a day.

After receiving the specified complex treatment decreased pain in the abdomen and mammary glands, palpation, pain, lesions of endometriosis and diffuse thickening in the breast, the prevalence of pathological entities.

Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal flora - I-II. ECG - without features. Estradiol levels decreased (223,1 PG/ml)and progesterone increased (8.3 nmol/l). Immunological studies level b-lymphocytes fell slightly, T-helper cells remained within the normal range, the source increased phagocytic activity and immunodeficiency is globulines fell, and reduced increased. According to the lipid cholesterol remained within normal limits at 5.27 mmol/l, HDL dropped slightly to 1,29 mmol/l and LDL increased to 3.19 mm/l haemoglobin rate decreased. An ultrasound of the genital organs was determined by the improved structure of the myometrium (generally fewer ekopozytywny polymorphic impurities, smooth contours inclusions, reducing the size of the source is increased uterine body). When breast ultrasound lots of inclusions in the upper outer, upper inner quadrants decreased in size. When corporateregister.com study indicated an increase in KPI to 10 day cycle, offset to the left in the maturation index (IP) with increasing number of intermediate cells.

The patient was discharged with improvement in General condition, gynecological status, the status of the mammary glands. After 1 year the patient is re-examined in the clinic. Clinical status, physical examination and palpation, ultrasound examination of the genitals and mammary glands, hormonal and immunological studies of lipid and corporatelogo remained virtually unchanged compared with the status after the course of therapy.

Summary. Thus, the patient received in the clinic treatment radon, endured the procedure well, fobs is cnyh negative phenomena were not. Observed remission for 12 months.

Example 3. Patient SP Sitko IS Diagnosed with Genital endometriosis. Complaints of lower abdominal pain that occur before and during menstruation, often not related to the cycle, chromazone before menstruation. Bimanual examination - an increase in the uterus up to 5-6 weeks., the body of the uterus heterogeneous consistency, with a rough surface, painful on palpation, sedentary, many adhesions. During examination: clinical blood and urine tests - without a pathology, ECG - without features. In the study of hormones in the blood was determined by the increased values of estradiol (328,2 PG/ml) and decreased levels of progesterone (4.4 nmol/l). Immunological studies have revealed violations of cellular immunity (excess levels of b-lymphocytes and T-helpers), disorders of phagocytic activity and decreased levels of immunoglobulins. According to the lipid cholesterol was slightly increased to 7.2 mmol/l, HDL 1.23 mmol/l and LDL of 3.28 mm/l haemoglobin rate was slightly elevated. An ultrasound of the genital organs was determined by multiple echopositive polymorphic inclusions with irregular contours around the myometrium. When corporateregister.com study indicated prolonged increase KPI (up to 19th day of the cycle), the right shift in the maturation index (IC) is dominated by the eating surface cells to 18 day cycle.

Treatment. The complex treatment consisted of destination gynecological radon irrigation, General radon baths and microenemas of radon water (200,0) drip method, exposure time 15 minutes, the temperature of 36°C, the concentration of radon water 180 NCI/l (6,5 kBq/l). All procedures were performed in one day, 2-3 days in a row, a break of 1 day, a course of 10 treatments. 2 hours after receipt of radon procedures or in interleaving with radon treatments a day was prescribed laser therapy. The wavelength of 0.89 μm, frequency mode - autoresonance, power of 10 W, for 10-15 seconds on each field effects. Field effects are selected depending on the hormone dependent diseases: in genital endometriosis and uterine fibroids - area projection of the body of the uterus, when breast - sectoral depending on the volume of the breast, from 10 to 16 fields of influence. The emitter is installed on another field effects with the touch of a field, when genital endometriosis and uterine myoma, the impact is within 15 minutes on the area of projection of the uterus, mastitis movement of the emitter is clockwise and radiare. On the nipple and areola laser treatment is not provided. Not earlier than 2.5-3 hours after ingestion of radon procedures consistently carried out by local treatment in the form of trays with malavita tampons with gel Malawi. Internal intake of mineral water were carried out daily, 30-60 minutes before meals, depending on the state of the hepatobiliary system, in the amount of 3.5 mg/kg of body weight 3 times a day.

After receiving the specified complex treatment decreased abdominal pain, bimanual study decreased pain, lesions of endometriosis, the prevalence of pathological entities.

Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal flora - I-II. ECG - without features. Estradiol levels decreased (198,7 PG/ml)and progesterone increased (11.7 nmol/l). Immunological studies level b-lymphocytes fell slightly, T-helper cells remained within the normal range, the source increased phagocytic activity and immunoglobulins decreased, and reduced increased. According to the lipid, cholesterol decreased - 6,36 mmol/l, HDL dropped slightly to 0.97 mm/l and LDL increased to 3.43 mm/l haemoglobin rate decreased. An ultrasound of the genital organs was determined by the improved structure of the myometrium (generally fewer ekopozytywny polymorphic impurities, smooth the contours of inclusions, reducing the size of the source is increased uterine body). When breast ultrasound lots of inclusions in the upper outer is m, the upper inner quadrants decreased in size. When corporateregister.com study continued improvement of the CRPD to 10 day cycle, offset to the left in the maturation index (IP) with increasing number of intermediate cells.

The patient was discharged with improvement of the General condition, gynecological status after 1 year re-examined in the clinic. Clinical status, physical examination and palpation, ultrasound examination of the genitalia, hormonal and immunological studies of lipid and corporatelogo remained virtually unchanged compared with the status after the course of therapy.

Summary. Thus, the patient received in the clinic treatment radon, endured the procedure well, negative side effects were not. Observed remission for 12 months.

Example 4. Patient Androva N.A. Diagnosis: uterine Fibroids. Complaints to feeling of heaviness in the lower abdomen, profuse menstruation, sometimes krivomazova before menstruation. Bimanual examination - an increase in the uterus up to 5-6 weeks., the body of the uterus heterogeneous texture, with large pockets of seals, uneven deformed surface, sedentary, many adhesions. During examination: clinical blood and urine tests - without a pathology, ECG - without features. In the study of hormones in the blood concentration of es is Radiola did not exceed standards (144,7 PG/ml); the progesterone level was reduced (2.8 nmol/l). Immunological studies have revealed violations of cellular immunity (several low content of b-lymphocytes and the ratio of T-helper cells), disorders of phagocytic activity and low levels of immunoglobulins. According to the lipid cholesterol was elevated to 7.93 mmol/l, HDL-C was of 2.23 mmol/l and LDL - 2,33 mm/l haemoglobin rate was increased. An ultrasound of the genital organs was determined by the heterogeneity of the structure of the myometrium, education on the rear wall of the womb (closer to the bottom of the uterus), which gives the sound track, some deformation of the contours of the body of the uterus, endometrial thickness in the second phase of the cycle - 12 mm When corporateregister.com study indicated prolonged increase KPI (21 day cycle), a sharp shift to the right in the maturation index (IP) with a significant predominance of superficial cells up to 18-19 day cycle.

Treatment. The complex treatment consisted of destination gynecological radon irrigation, General radon baths and microenemas of radon water (200,0) drip method, exposure time 15 minutes, the temperature of 36°C, the concentration of radon water 180 NCI/l (6,5 kBq/l). All procedures were performed in one day, 2-3 days in a row, a break of 1 day, a course of 10 treatments. 2 hours after receipt of radon procedures or in interleaving with radon the procedures a day was appointed laser therapy. The wavelength of 0.89 μm, frequency mode - autoresonance, power of 10 W, for 10-15 seconds on each field effects. Field effects are selected depending on the hormone dependent diseases: in genital endometriosis and uterine fibroids - area projection of the body of the uterus, when breast - sectoral depending on the volume of the breast, from 10 to 16 fields of influence. The emitter is installed on another field effects with the touch of a field, when genital endometriosis and uterine myoma, the impact is within 15 minutes on the area of projection of the uterus, mastitis movement of the emitter is clockwise and radiare. On the nipple and areola laser treatment is not provided. Not earlier than 2.5-3 hours after ingestion of radon procedures consistently carried out by local treatment in the form of trays with malavita and tampons with gel Malawi. Internal intake of mineral water were carried out daily, 30-60 minutes before meals, depending on the state of the hepatobiliary system, in the amount of 3.5 mg/kg of body weight 3 times a day.

After receiving the specified complex treatment decreased the feeling of heaviness in the lower abdomen, bimanual study the body of the uterus has gained a lot of mobility, the size of the formations, giving the acoustic track, decreased, the structure is ur myometrium has become more homogeneous. Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal flora - I-II. ECG - without features. Estradiol levels decreased (91,2 PG/ml)and progesterone increased (14.9 nmol/l). Immunological studies level b-lymphocytes was increased T-helper cells, on the contrary, remained within normal limits, the source increased phagocytic activity and immunoglobulins decreased, and reduced increased. According to the lipid cholesterol decreased to 5,79 mmol/l, HDL dropped slightly - up to 1.32 mmol/l and LDL increased to 3.85 mm/l haemoglobin rate decreased. An ultrasound of the genital organs was determined by the improved structure of the myometrium (decreased heterogeneity of the myometrium, sizes exonerating education decreased the size of the source is increased uterine body). When corporateregister.com study there was a decrease in the CRPD after 12 days of the cycle, offset to the left in the maturation index (IP) with increasing number of intermediate cells with a 13 day cycle.

The patient was discharged with improvement of General and gynecological status; re-examined in the clinic after 1 year. Clinical status, physical examination and palpation, ultrasound examination of the genitalia, hormonal and immunological studies of lipid and corporatelogo ostalis is virtually unchanged compared with the status after the course of therapy.

Summary. Thus, the patient received in the clinic treatment radon, endured the procedure well, negative side effects were not. Observed remission for 12 months.

In this way at the gynecology Department of Pyatigorsk clinic were treated 102 patients suffering from hormone-dependent gynecological diseases, including 37 women (36,28%) with genital endometriosis, 31 (30.39 percent) - with uterine fibroids and 34 (33,33%) with diffuse proliferative dishormonal breast cancer developed on the background of hormone dependent diseases of the genitals. The control group consisted of 92 patients: 32 women (34,78%) with genital endometriosis, 31 (33.7 per cent) with uterine fibroids and 29 people (31,52%) with diffuse proliferative dishormonal breast cancer. The patient control group received the radon treatment in the form of baths, gynecological irrigation and microenemas temperature of 36°With exposure time of each procedure 15 minutes, 40 or 180 NCI/l, at a rate of 10-12 procedures. Both groups in clinical terms were identical. All patients with genital endometriosis and more than half of the patients with uterine fibroids complained of pain in the lower abdomen, appearing in the premenstrual or menstrual periods, spotting before menstruation. In patients with uterine myoma is ATCI was observed profuse bleeding during menstruation, a long period of bleeding. Mastitis women reported intermittent pulling and arching pain in mammary glands, associated and not associated with the cycle. All patients were determined foci of diffuse seals in the mammary glands, painful on palpation.

Patients of both groups underwent the study of hormones in the blood during the second phase of the menstrual cycle (FSH, LH, prolactin, estradiol and progesterone), in some patients (50%) and immunological blood tests, as well as all women - the study of lipid, ultrasound scan of genitalia, mammary glands, data were evaluated corporateregister studies before and after treatment.

In the study of blood hormones in women in both groups was determined by the increased values of estradiol and reduced progesterone level. It should be noted that patients with genital endometriosis estradiol concentration exceeded the average values in healthy women (115,6+to 9.5 PG/ml) on average by 115.7%, uterine fibroid - by 74.3%, mastitis - of 101.7%. Progesterone was reduced more evenly when all nosologies. Immunological studies were carried out in some patients: 29 women (42,03%) with genital endometriosis, 24 (38,71%) with uterine fibroids and 28 (44,44%) with diffuse proliferative dishormonal diseases is elochnoy cancer. It was noted violations of cellular immunity, phagocytic activity and levels of immunoglobulins in 23 patients (79,31%) with genital endometriosis of the total surveyed, 16 (66.67 per cent) - with uterine fibroids and 21 (75%) with diffuse proliferative dishormonal breast cancer. According to lipidogram cholesterol was elevated source in 31 patients (83,79%) genital endometriosis in the study group and 25 (78,13%) control, 22 women 70,97%) with uterine fibroids main group and 24 (77,42%) and control, 27 patients (79,41%) with diffuse proliferative dishormonal breast cancer, and the main group and 18 (62,07%) control. Violations of the content of HDL and LDL were observed in virtually all patients in all nosological groups of observations. Haemoglobin rate was increased from 34 patients (91,89%) genital endometriosis main group, 28 (87,5%) - control group of 28 women (90,32%) with uterine fibroids main group and 26 (83,87%) control, 23 patients (67,65%) with diffuse proliferative dishormonal breast cancer, and the main group and 23 (79,31%) - control.

Ultrasonic examination of the genitalia in genital endometriosis was determined by multiple echopositive polymorphic inclusion of heterogeneous with irregular contours, in the myometrium different parts of the body of the uterus. If mi is the Mach uterus was determined in General thickening of the walls of the uterus, nodular inclusions, giving the acoustic shadow deforming the outer and inner contours of the body of the uterus. When breast ultrasound in patients with diffuse proliferative dishormonal breast cancer were registered multiple diffuse located lots of inclusions for the most part in the upper outer, upper inner, and sometimes even lower outer quadrants.

Kolotilina studies were conducted prior to sanatorium-resort treatment of patients: 62,32% of patients with genital endometriosis, 61,29% with uterine fibroids and 61,91% with diffuse proliferative dishormonal breast cancer. It was noted long-term increase of the CRPD (up to 18-19 day cycle), the right shift in the maturation index (IP) in all the examined according to the parameters of patients: with genital endometriosis - 21 (56,76%) and 22 women (68.75 kilopascals%) and control group respectively, with uterine myoma - 24 (77,42%) and 21 (67,74%) people with diffuse proliferative dishormonal breast cancer - 27 (79,41%) and 22 (75,86%) patients, respectively.

After comprehensive treatment using radon procedures, laser therapy, internal mineral water and local processing (bath with malavita and tampons with gel Malawi), showed a significant improvement is Oceania reduced pain in the abdomen and mammary glands, reducing the size of lesions bimanual, palpation and ultrasound studies have all observed patients. Patients in the control group after radon as monofactorial treatment indicators of clinical status and data bimanual, palpation and ultrasound were somewhat worse. In this group often remained pain in one way or another stepny, bimanual, palpation and ultrasonography dimensions endometriosis foci and foci of seals in the mammary glands was decreased, but to a lesser extent than in patients of the main group, and myomatous nodes are fairly weakly yielded to the impact.

In the study of blood hormones in women in the study group after treatment was observed more pronounced decrease in the level of estradiol and increase progesterone than in patients of the control group. Thus, in patients of the main group after treatment with genital endometriosis estradiol concentration exceeded the average values in healthy women (115,6±and 9.5 PG/ml) in average by 54.7%, uterine fibroid - 41.8%, mastitis - 37.2%. Patients in the control group, the concentration of estradiol was higher than the average values in healthy women (115,6+to 9.5 PG/ml) average 91,2%, uterine fibroid - 64.1%, mastitis-is and 63.7 percent (see the drawing).

Immunological studies after treatment indicators of cellular immunity, phagocytic activity and levels of immunoglobulins in all patients in the study group observations tended to normalize (i.e. excess values were determined by a tendency to decrease their values, and when the original lower values to higher levels of performance). Patients in the control group was observed unidirectional trend towards higher levels of performance (immunostimulatory effect of the applied treatment factor)that in cases with initially reduced performance is certainly a positive aspect of the effect of treatment factor, and when the original elevated values may aggravate disorders.

According to lipidogram cholesterol after treatment was reduced in all patients in the primary group and remained elevated in the control group. The content of HDL and LDL and atherogenic factor tended to normalize only in patients of the main group and in the control group, these figures remained either unchanged or haemoglobin rate was slightly increased.

According to corporateregister studies during treatment showed normalization of the duration of the second phase of the cycle in all patients (above the level of the CRPD to 10-13 days of the cycle, some offset to the left in IP after 11-14 days of the cycle). More noticeable and positive changes corporateregister.com the study was registered in patients of the main group.

The application of complex therapy in all cases, observations were noted long-term remission (up to 11-12 months). Research in the remote period showed no marked tendency to deterioration in clinical status, bimanual, palpation and ultrasound, hormonal, immunological studies of lipid parameters and corporatelogo in patients of the main group. Patients of the control group, despite the long-term clinical improvement (7-9 months), after 7-9 months. there was a slight increase in the concentration of estradiol, decreased levels of progesterone, some destabilization of immunological parameters, lengthening the first phase of the cycle according to corporateregister research, deterioration of clinical status, data bimanual, palpation and ultrasound.

Thus, the complex method of treatment in many settings is the predominant compared to monofactorial by radon.

A method of treating patients suffering from hormone-dependent gynecological diseases, characterized in that sick ol the lead radon treatment in the form of baths, gynecological irrigation, microenemas, laser therapy in autoresonance mode with variable frequency laser apparatus regardless of the frequency characteristics of the human body with a wavelength of 0.89 μm, 10 watt on the area of projection of the uterus with genital endometriosis and uterine myoma with exposure time of 15 min and mammary glands with diffuse proliferative mastopathy with choice fields impact the sector from 10 to 16 10 to 15 on each field effects; local treatment, no earlier than 2.5-3 h after radon procedures sequentially: the first stage is carried out trays with malavita in a dilution of 1:5 with exposure time of 15 min, the second stage - after removal from the vagina of the solution is injected gel Malawi on the swab for 4-6 h, the treatment is carried out in conjunction with internal mineral water for 30-60 minutes before meals, 3 times a day for 3.5 mg/kg of body weight.



 

Same patents:

FIELD: medicine, gynecology.

SUBSTANCE: as a suggested preparation one should apply dried defibrinated or non-defibrinated blood of Siberian stags or spotted deer. The preparation suggested should be prescribed perorally per 25 mg (1 capsule) twice daily, therapy course corresponds to 25-35 d. Application of this preparation in women at normal level of gonadotropins, positive gestagen-test, with no hyperandrogenia and hyperprolactinemia at the absence of menstrual cycle of more than 3 mo provides the onset of menstruations at stable positive effect. After carrying out 3 therapeutic courses no relapses had been observed.

EFFECT: higher efficiency for regulating menstrual cycle.

3 cl, 2 ex, 3 tbl

FIELD: organic chemistry of heterocyclic compounds, pharmacy.

SUBSTANCE: invention relates to new bicyclic heteroaromatic compounds of the general formula (I): wherein R1 represents phenyl optionally substituted with NHR5 or OR5; R2 represents (C1-C4)-alkyl or phenyl; R5 represents phenylcarbonyl, (C4-C6)-heterocycloalkylcarbonyl, (C2-C8)-alkenylsulfonyl and others; Y represents nitrogen atom (N); Z represents -NH2 or -OH. A represents sulfur atom (S) or a bond; B represents -N(H) or oxygen atom (O); X1-X2 represent C=C, -NH-C(O), C=N and others; Proposed compounds show agonistic activity with respect to LH receptor and can be used in medicine.

EFFECT: valuable medicinal properties of compounds.

10 cl, 34 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with composition for fertilization in vitro and the system for its delivering (device). The composition suggested contains steroid at the quantity of below 5% (weight/weight), that is: 4.4-dimethyl-5α-cholesta-8.14.24-trien-3β-ol, hemisuccinate of 4.4-dimethyl-5α-cholest-8.14.24-trien-3β-ol; 5α-cholest-8.14-dien-3β-ol; hemisuccinate of 5α-cholest-8.14-dien-3β-ol; (20S)-cholest-5-en-3, 20-diol; N-(methionine)amide of 3β-hydroxy-4.4-dimethyl-5α-chol-8.14-dien-24-oic acid or cholest-5-en-16β-ol, and, also, additive (water-soluble protein or phosphoglyceride). Delivering system has got either one foramen or one cavity that contains the composition mentioned as a solid product or solution. The composition of sterols contains no constituents negatively affecting oocytes and could be dissolved in aqueous medium without physical impact (that is, heating, mixing or ultrasound treatment).

EFFECT: higher efficiency of fertilization in vitro.

8 cl, 5 ex, 3 tbl

FIELD: medicine, urology.

SUBSTANCE: at the background of curative starvation a patient should be prescribed for peroral intake of 100 ml tincture or 1 teaspoon tincture out of bees twice daily in the morning and in the evening, and, also, 200 ml hempseed decoction based upon milk twice daily in the morning and in the evening at the course of 5 d. On the 3d, 5th, 7th d of starvation one should perform hepatic and biliary ductal purification at 7 p.m. at the intake of 250 ml natural apple juice at 4 p.m., since the 1st to the 7th d of starvation one should daily apply enemas: in the morning - purifying enema with juice of 1 lemon, in the daytime - curative enema with Artemisia decoction. One should daily perform rectal prostatic massage followed by applying microenemas with 30 ml composition containing the tincture of Sophora, oil of wheat germs, decoction of medicinal plant of antiphlogistic action taken at weight ratio of 1:0.5:2, correspondingly, at the course of 10 d long. Duration of curative starvation lasts for 7 d, not less. The method provides shortened terms of therapy due to simultaneous normalization of body metabolic processes, purification of organs against bacteria and parasites.

EFFECT: decreased body allergization.

6 cl, 2 ex

FIELD: veterinary science.

SUBSTANCE: on should apply 1-(ethoxy)sylatrane as a stimulating agent for reproductive capacity in female furred animals and viability of their offspring. The innovation enables to improve reproductive function in females and viability of whelps.

EFFECT: higher efficiency.

3 ex, 3 tbl

FIELD: pharmaceutical industry.

SUBSTANCE: invention provides therapeutical formulation for improving fertility and treating sterility caused by polycystic ovary syndrome, which composition is characterized by that formulation thereof involves use of dipeptidylpeptidase IV inhibitor. Treatment of polycystic ovary syndrome-caused sterility is high successful with effective active ingredient concentration equal to 1 μM. When dipeptidylpeptidase IV inhibitor is administered, luteinizing hormone and testosterone levels in blood are normalized. Claimed compounds are low toxic for warm-blooded animals and humans.

EFFECT: widened choice of efficient antisterility drugs.

7 cl, 3 ex

The invention relates to medicine, in particular to urology and andrology, and can be used in the treatment of autoimmune infertility in men

The invention relates to medicine, in particular to the gynecologist, and for the treatment of women suffering from endocrine forms of infertility

The invention relates to medicine, in particular to urology, andrology

The invention relates to medicine, in particular to obstetrics and gynecology, and relates to means for the treatment of chronic endometritis

FIELD: medicine, ophthalmology.

SUBSTANCE: in a quadrant being the most similar to pathological process one should form a through trepanation scleral foramen in area of flat part of ciliary body. In area of this foramen it is necessary to fulfill transconjunctival laser choroid coagulation at wave length of 800 nm and radiation power of 800 mW. After that medicinal preparations should be injected subconjunctivally. The innovation is directed for improving the access and developing optimal concentration of medicinal preparations in affected tissues of posterior department of an eyeball that provides improved visual functions.

EFFECT: higher efficiency.

3 ex

FIELD: gynecology.

SUBSTANCE: one day after operation, while carrying out continuously integrated anti-inflammatory treatment, infrared magnetic-laser therapy through anterior abdominal wall onto the region of projection of uterine appendages is administered under following conditions: wavelength 0.89 μm, pulse recurrent rate 1500 Hz, magnetic field intensity 25-50 mTl, emission power density 2.9-3.5 W, emission exposition time 4 min for two zone in one session. Procedures are carried out daily in morning time over a 5 days period.

EFFECT: lack of invasiveness and allowed stopping inflammation of deeply located pathologic focuses.

FIELD: medicine, ophthalmology.

SUBSTANCE: the present innovation deals with treating different forms of amblyopia. It is necessary to carry out medicinal correction of neurological disorders in a patient that includes vasoactive preparations, venotonics, nootropes and metabolics. One should conduct electrophoresis of spasmolytics onto area of jugular vertebral department at current power being 0.5-1.0 mA/sq. cm per 10 min, daily. Simultaneously,, it is necessary to carry out argon-laser stimulation of retinal central area and projection of papillo-macular bundle, about 150-200 impulses/seance, radiation power being 0.05 W, radiation diameter of 1000 mc, exposure time of 0.01 sec, wave length being 498-514 nm every other day. Therapy course lasts for 10 d. The innovation enables to achieve positive dynamics in treating severe forms of amblyopia, restore visual function and obtain correction of neurological disorders.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: medicine.

SUBSTANCE: method involves carrying out contact-mode laser photocoagulation with laser having wavelength of 1064 nm and power of 6-10 W. exposure time is equal to 2-4 s. Autoblood injections are additionally introduced before applying laser radiation treatment, in peripheral zone relative to hemorrhage source.

EFFECT: enhanced effectiveness in arresting gastroduodenal hemorrhages.

FIELD: medical engineering.

SUBSTANCE: device has power supply source, control system, laser radiation source and an additional built-in magnetic system composed of permanent magnets of magnetic induction equal to 0.1-1 mTesla units in the working area and built-in coil system. Current pulses are supplied to the coil system synchronously with laser pulses. Coil system magnetic induction is equal to 25-75 mTesla units in the working area. The pulsating induction extinguishes in time in alternating sign mode.

EFFECT: enhanced effectiveness of high intensity treatment.

2 dwg

FIELD: medicine.

SUBSTANCE: device has case made in form of cylinder or cone. There is internal cone-shaped cavity in the case which cavity switches to spherical shape at its top part. Radius of spherical cavity equals to 0,19-0,45 diameter of base of internal cone-shaped cavity which is selected to be equal to 11-16 mm. Surfaces of cone-shaped and spherical parts of internal cavity of device are made for light dissipation and for reflection of laser radiation with light reflection factor of 0,6-0,8. Through holes are made in case for supply laser radiation into internal cavity by means of light guide. Prism, dissipating laser radiation, or spherical lens is placed into hole. Lower part of device is provided with removable protection ring made of polymer material.

EFFECT: uniform irradiation of front section of eye.

4 cl, 2 dwg, 1 ex

FIELD: medicine, dermatology.

SUBSTANCE: one should perform laserophoresis with IR-laser of gelling form of medicinal preparation based upon pantohematogen in projection of large vessels of the upper and lower limbs by alternating the impact every other day in axillary and cubital areas at irradiating popliteal and inguinal areas. Impulse frequency corresponds to patient's respiration frequency. Impact terms correspond to about 4-5 min at the field to achieve stationary-regressing stage. Then it is necessary to conduct the course of baths with pantohematogen solution at concentration being 0.03-0.08 g/l, at gradually increasing water temperature from 36-37°C up to 39-40°C and shortening the time for the procedure from 15 min up to 8 min for the course of 10-12 procedures every other day. The innovation has pronounced antiphlogistic action, activates total immunity, improves skin microcirculation along with stabilization of proliferative and increases metabolic-trophic processes, normalizes locomotor articular function at accompanying psoriatic polyarthrites.

EFFECT: higher efficiency of therapy.

3 ex

FIELD: veterinary medicine.

SUBSTANCE: method involves exposing tendon and its sheath injury zone to laser radiation of pulse succession frequency equal to 512 Hz, power of 16 W for 6 min on the background of single intravenous Hyonate dose containing 40 mg of sodium hyalurate as active agent.

EFFECT: enhanced effectiveness of treatment; accelerated treatment course.

FIELD: medicine.

SUBSTANCE: method involves acting upon biologically active points. To do it, pathologically active orbital points are determined. The points are treated with infrared radiation in continuous mode until pathological activity is inhibited. Mirticam preparation is administered at a dose of 1 teaspoon three times a day after having taken meals.

EFFECT: improved vision acuity; increased accommodation reserve; normalized electrophysiological retina properties.

FIELD: medicine.

SUBSTANCE: method involves systemically introducing a photosensitizer followed by tumor irradiation with laser radiation. Laser radiation is applied in contact mode with 200-400 mW at the exit from light guide and applying pressure to tissue surface pretreated with glycerol with force of 0.1-0.5 kg/cm2 in tumor zone using micro lens.

EFFECT: enhanced effectiveness of treatment.

1 dwg

FIELD: veterinary medicine.

SUBSTANCE: method involves washing dead bee bodies in 0.5% household soda solution and then three times in cooled boiled water, drying and individual grinding to bring dead bees bodies and ambrosia to dust state and mixing them in equal volumes, treating with ultrasound under known conditions and adding 40% ethyl alcohol, making infusion in dark place during given time, filtering, diluting with twice-boiled water to reach 20% alcohol concentration and prepackaging.

EFFECT: enhanced effectiveness of treatment; increased hemoglobin, erythrocyte number and improved biochemical blood properties.

2 tbl

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