Ointment for treatment of scars

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to ointment used in treatment of scars by external using on a patient body. Ointment for treatment of scars comprises wax, vegetable oil, heparin, lydaze, glycerol and dimethylsulfoxide in the following ratio of components per 100 g: wax, 13-15 g; heparin, 5000-10000 U; lydaze, 64-128 U; dimethylsulfoxide, 10-15 ml; glycerol, 10-15 ml, and vegetable oil, the balance. Invention provides enhancing effectiveness in treatment of patients and the absence of adverse complications.

EFFECT: improved, enhanced and valuable medicinal properties of ointment.

1 tbl, 3 ex

 

The invention relates to medicine, namely to the compositions of ingredients with therapeutic purpose by external application to the human body.

Closest to the claimed ointment and selected as a prototype antiseptic agent (patent RF №1805952, IPC a 61 K 9/06, 1993) contains wax, vegetable oil, 15%aqueous solution rivanol in the following ratio, wt.% wax 13-13, 15%aqueous solution rivanol 1,2-1,3, vegetable oil - else.

The disadvantage of this ointment is limited its scope.

The technical result is to increase functionality, namely improving the ability of the stretch scars, improve the trophic tissue, prevent or reduce muscle atrophy and changes in the joints and steam-articular tissues and the resorption of scars.

The technical result is achieved by the fact that the ointment for the treatment of scars includes dissolved in the fat product product of bees - wax, as the fat of product used vegetable oil, a direct anticoagulant is heparin, glycerol activates metabolic processes, lydasum has hyaluronidase activity that specifically cleaves the molecule of acid mukonoweshuro hyaluronic acid is a major component of interstitial substance connecting cable Inc is th tissue.

Dimethyl sulfoxide has anti-inflammatory, analgesic action, enters at high speed through the skin, blends well with the medicinal substances in the following ratio of components: wax 13-15 g; heparin 5000-10000 IU; lydasum 64 u; dimethyl sulfoxide and 10 ml; glycerol, 10 mg; vegetable oil - else.

The drug reduces the viscosity of the interstitial substance, and thereby increases tissue permeability and facilitate the movement of fluid in the interstitial spaces.

Comparative analysis of the prototype showed that the claimed composition ointments differs from the known to the introduction of new components, namely heparin, lidz, dimethyl sulfoxide and glycerol.

Analysis of the known ointments used for the same purpose, showed that a combination of vegetable oils, waxes, glycerin, lidz, heparin, dimethyl sulfoxide, in which the ingredients are soluble, in practice not met on set and ratio of ingredients.

The ointment is manufactured as follows.

Vegetable oil is brought to a boil in a steam bath, after which it add the wax to dissolve, and then after straining through a double sterile gauze layer added to a solution of heparin and glycerin. In the slightly cooled structure add hyaluronidase dissolved in dimethyl sulfoxide. P is obtained mass is stirred until a homogeneous mixture.

The cooled ointment is applied sterile medical spatula in a thin layer on the desired surface and is voiced by ultrasound.

The suitability of ointments for more than 2 years after preparation when stored in a dark place at room temperature.

therapeutic properties of ointments consist of the following.

Vegetable oil contains triglycerides of polyunsaturated fatty acids, promoting regeneration of tissues.

Wax, among others used for ointments bee products, has the lowest reactivity, in the presence of triglycerides able to allocate to the wound oxidative oxygen, promoting regeneration of tissues.

Heparin affects the coagulation factors, inhibits the activity of thromboplastic plasma, inhibits the transition of prothrombin to thrombin and fibrinogen to fibrin, reduces platelet aggregation. Activates the fibrinolytic properties of blood, lowers cholesterol and β-lipoproteins, has an immunosuppressive effect, improves, restores, in most cases, the microcirculation of tissues.

Lydasum has hyaluronidase activity that specifically cleaves the molecule of acid mukonoweshuro hyaluronic acid, which is the main component of the interstitial substance of connective tissue. Reduces viscosity megalocnus the substance, and thereby increases tissue permeability and facilitate the movement of fluid in the interstitial spaces.

Glycerin has a softening and simultaneously astringent action has a high hygroscopic, lubricating properties. When applied to the skin activates it metabolic processes.

The sulfoxide with high activity penetrates the skin, in most cases, is used in combination with other medicinal substances previously dissolved in it for better and deeper penetration. Has anti-inflammatory, analgesic, antimicrobial and weak antihistaminic properties, several increases the sensitivity of adrenergic receptors for adrenaline.

Ointment activates metabolic processes in the scar area, improves microcirculation, stretches the scar tissue, improves trophic tissues, prevents muscle atrophy, and dissolves scars.

To enhance the permeability of the above ointment is applied ultrasound. Ultrasound therapy is considered one of the most common and highly effective methods of treatment of various diseases. Ultrasound without significant absorption ointment penetrates the tissues of the body, has a strong analgesic, antispasmodic, anti-inflammatory and General tonic effect, stimulates blood and lymph circulation, regenerative processes. Under the action of ultrasonic kolebaniya the course of redox processes, complex protein complexes more rapidly depolymerized (split) to organic molecules, and stimulates the action of several enzymes. The applied ultrasound frequency of 800 MHz, continuous wave, a power of 0.4 W/cm2lasting 10-15 minutes.

The ointment does not cause side effects and are absolutely harmless.

Examples of specific performance ointments on marginal and average values of components shown in the table.

therapeutic effect of the ointment tested in the whole range of changes in the quantitative content component.

The ointment was tested on forty-six patients with various burns and post-operative scars.

Example 1.

Patient O., 7 years. Post-burn scars in the area of both hips and inner surfaces of both legs (2-3 degree burns). Was treated for 1.5 months. Drawn with rough scars. After 2 weeks of treatment (ointment + ultrasound) skin in the area of scars became smooth, smooth, slightly hyperemic. The treatment was with a good result.

Example 2.

Patient C. for 22 years operated injuries. Across the neck rough scar, allocated roughly superimposed seams. The surgery was 2 years ago. Treated all the time, applying various ointments and methods, without speakers. 12 days after treatment, the above method is a positive trend.

Example 3.

Bol is nye So 38 years. Burn the right hand with the rough scars. Movement in the brush limited. For 2.5 years, was treated in the burn Department without much improvement. 15 days after the start of treatment ointment and ultrasound scars almost subsided, softer, some scars resorbed. The movement of the bone is restored (according to the patient - it is a miracle ointment).

Table
Name of the componentQuantitative content
Wax13,0 g14.0 g15.0 g
Heparin500010,000 units10,000 units
Lydasum64%128 units128 units
Glycerin10.0 mg10.0 mg10.0 mg
The sulfoxide10.0 ml10.0 ml10.0 ml
Vegetable oil100100100

Ointment for the treatment of scars, containing wax, oil, characterized in that it further comprises heparin, hyaluronidase, glycerol and dimethyl sulfoxide, with the following content of components in 100.0 g:

Wax13-15 g
Heparin5000-10000 units
Lydasum64-128%
The sulfoxide10-15 ml
Glycerin10-15 ml
Vegetable oilRest

after application of the ointment effect of ultrasound frequency of 800 MHz, a power of 0.4 W/cm2within 10-15 minutes



 

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