Anti-inflammatory ointment

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to inflammatory agents. Invention proposes the ointment that comprises liquid potassium humate, birch tar, sodium silicate, vaseline wherein the potassium liquid humate comprises the humic substances in the amount 4.5 g/l, not less. Invention provides enhancing storage time, stability, high effectiveness and the broad spectrum of effect.

EFFECT: valuable medicinal and pharmaceutical properties of ointment.

2 cl, 6 ex

 

The invention relates to medicine and veterinary medicine, namely to biologically active ointments with low functionality, availability, composition and prefectionist treatment, used as anti-inflammatory, wound healing, analgesic in the treatment of various diseases, mainly skin diseases, diseases of the musculoskeletal system of humans, animals, birds.

In veterinary medicine in a large number of required accessible means for the treatment of purulent-necrotic disease of the limbs of animals, such as microbatteries, suppurative disease such as laminitis, laminet, pricked over, cuts, swelling of limbs, hooves, as well as for prevention and treatment of mastitis.

Known bactericidal acaricide ointment for the treatment of skin diseases of animals containing salicylic acid or aspirin or phenacetin, zinc oxide or magnesium oxide, tar, lanolin anhydrous, sulfur, water, turpentine and petroleum jelly, further comprises anionic surfactant, based on the alkyl sulphates at a certain ratio of components (see RF patent №2128041, a 61 K 31/00, And 61 To 33/04, publ. 1999).

Known bactericidal acaricide ointment recommended for the treatment of skin diseases of animals and containing sulfur, salicylic acid or acetylsalicylic or phenacetin, zinc oxide or magnesium oxide, Degot is, the Lysol or creolin bisphenolic coal or carbolic acid, anhydrous lanolin, turpentine, petroleum jelly and water. (see RF patent №2107495, a 61 K 31/00, a 61 K 33/00, publ. 1998).

Known ointment to treat wounds farm animals, containing the following ratio of components, wt.%: the Ichthyol 3-8; copper sulphate 0.5 to 7,4; ointment base, vaseline or tar - rest (see RF patent №2035183, a 61 K 35/78, a 61 K 31/00, 1998).

Known drugs for the treatment of purulent podteret animals Vishnevsky ointment or bandages with tar 5-6 days. However, when such tools, the effectiveness of the treatment is minimal.

Also known ointments antiseptic agents (Ichthyol, birch tar, sulfur-tar ointment and others), as well as preparations of copper sulfate used for treatment of purulent diseases of animals.

However, in some cases, their action is not effective: low anti-inflammatory effect, low penetrating power.

Known ointment to treat wounds farm animals, containing the following components, wt.%: the Ichthyol 3-8; copper sulphate 0.5 to 7,4; ointment base, vaseline or tar - rest (see RF application No. 92004825, IPC a 61 K 35/78, 1994).

Due to the numerous negative side effects antimastit preparations containing antibiotics, sulfonamides, nitrofur the Ana, the role of preparations for cutaneous application.

Known ointment for veterinary use as anti-inflammatory, wound-healing agent with mastitis, consisting of components, wt.%: ointment base of 27.5-65,5; Balis 22,0-36,5; peptide fraction koumiss with molm 500-4000 Da 2-2,5; a blend of essential oils 0,9-1,2; pectin of 0.2-0.3; distilled water - the rest. As essential oils are used peppermint oil, eucalyptus oil, fir oil, oil of lavender, pink and sea buckthorn oil in the amount of 1.5-2.0 wt.%. (see RF patent №2187302, a 61 K 31/00, a 61 K 35/78, a 61 K 9/06, publ. 2002).

Ointment complex has a small storage period, with the possibility of its application associated with an individual reaction to essential oils.

For the treatment of mastitis suggested many preparations for cutaneous applications - berlinerin, levomekol, thixotropy, polisariocontrolled, wiveton, DMSO-90, DMSO with antibiotics (Rodin I.A. Mastitis cows: etiology, diagnosis and treatment. Krasnodar, Kuban state agrarian University, 1999, s-96).

Well-known medication for the treatment and prevention of mastitis in cattle, containing, wt.%: ristomycin 3-5, lanolin 20-40, vaseline oil - other (see RF patent №2135166 And 61 To 35/70, publ. 1999).

Known drug for the treatment of cracks in mastitis containing antimicrobial substances and igrovoy the basis of the following ratio of ingredients, %: incense powder 1-10, green tea powder 1-10, olive oil 65-88, yellow wax 10-15 (see USSR author's certificate No. 304951, a 61 K 9/06, publ. 1971).

The disadvantages of the known ointments include: high cost, limited resource base, relatively long periods of wound healing and relieve inflammation.

In medicine rapidly growing demand for medicines for the treatment of diseases such as psoriasis, arthrosis, arthritis. In addition, there is a disadvantage in protivopozharnih drugs and ointments for the treatment of bedsores in connection with complex surgical diseases.

Known ointment for external use as an analgesic remedy for the treatment of arthrosis, arthritis, having a composition, wt.%: oil of terpentine 14-16; eucalyptus oil 9-11; oil of camphor 14-16, birch tar, 19-21; Vinylinum 4-6; butter melted - the rest (see RF application No. 94023371 And 61 To 31/075, a 61 K 9/06, publ. 1996).

Known application of application of a solution of cholesterol ester of oleic acid in vaseline oil for the treatment of diseases of the joints, such as arthritis (see RF patent №2008855, A 61 F 5/00, a 61 K 31/00, publ. 1994).

Known ointment for the treatment of inflammatory diseases of the joints, containing (parts): beeswax 10-300, pine resin 10-300, olive oil 300-600, lard 100-300 (see RF patent №2165754, a 61 K 9/06, a 61 K 35/78, And 61 To 3/64, A 61 K 35/12, a 61 P 17/02, publ. 2001).

Known protivopozarnyi drug - plaster "Sliped", contain salicylic acid, sulfur, precipitated, natural rubber, anhydrous lanolin, pine rosin, and other components (Medmaravis. Medicinal product. - M.: Medicine, Vol.2, 1986, s).

The disadvantages of it is that the parameter - adhesion - unstable during storage, if the production requires a high quality of raw materials.

Due to the wide prevalence of skin diseases in people of different age groups, in particular psoriasis, the challenge of reducing the cost of treatment and improving the means and methods of treatment remains relevant. Psoriasis is one of the most common chronic dermatosis. Local treatment of skin diseases is to relieve swelling, redness, itching. For this purpose, liniments, lotions and ointments.

Known propolis ointment for the treatment of psoriasis, containing mainly bee products: propolis, beeswax (yellow), honey from ratnatraya, rosin and fatty basis in the form of vegetable oil at a ratio of components (see RF patent №2155597 And 61 To 35/64, a 61 K 9/06, publ. 2000).

Also known ointment for the treatment of psoriasis containing the powder of the seed of Psoralea kostandovo (Psoralea drupaceo Bye), penicillin and the vase is in the following ratio of components, parts: the powder of the seed of Psoralea kostandovo 2.0 to 2.5, penicillin 4,5-5,5 mlled vaseline to 100% (RF patent No. 1787033, a 61 K 35/78, publ. 1993).

The presence of penicillin restricts the use of ointments due to possible allergic reactions. The duration of treatment with this ointment is great enough - to seven weeks.

Known ointment for the treatment of psoriasis, containing, wt.%: an aqueous extract of the fungus 5-6, 40%, alcohol extract of celandine 3-5, salicylic acid 2-3 vaseline 42-45, lanolin 42-45 (RF patent No. 2171683, a 61 K 35/78, publ. 2001).

Known ointment for the treatment of psoriasis, containing a series of tripartite, greater celandine and birch tar, further comprises a sorrel horse (root) with the following ratios, wt.%: a series of tripartite 20-30, celandine 10-20, horse sorrel (root) 10-20, birch tar the rest (RF patent No. 2171682, a 61 K 35/78, a 61 K 9/06, And 61 R 1/16, 2001).

Known ointment for the treatment of skin diseases, containing lanolin, powders of medicinal plants in the following ratio of components, g: grass and flowers celandine 8-10; plantain leaves, and/or medium and/or lanceolate 8-10; flowers Lily of the may 8-10; grass and flowers chamomile 8-10, and honey flower may 10-12; protein raw chicken eggs 6-8; eucalyptus oil 0,3; lanolin 5-7, and as ointment bases with the idol medical 100,0-110,0 (see RF patent №2107510, a 61 K 35/78, publ. 1998).

Known cure for psoriasis, including carbon dioxide extract of Abies wood greenery in the form of ointments by the following recipe, g: extract of fir 2,0-0,1 vaseline to 100.0. (see RF patent №2058785, a 61 K 35/78, publ. 1996).

Known ointment for the treatment of skin diseases: eczema, psoriasis, neurodermatitis, containing a mixture of pine oil and aqueous extract of Siberian fir, lanolin and petrolatum (see RF patent №2074730 And 61 To publ. 1997).

Known ointment to Reproduce for the treatment of psoriasis, comprising, by wt.%: the Manchurian aralia 0,9-1,0, burdock felt 0,9-1,1, a series of tripartite 0,95-1,1, celandine from 0.9 to 1.15, flowers lnjanki of 0.4-0.6, Angello 1,0-1,1, gum Arabic 0,4-0,6, glycobiologie mucus of 0.4-0.6, chitin crab 1,9-2,0, birch tar, 0,5-0,6, essential oil fir Belokolos of 0.4-0.5, wasgonna water fir Belokolos of 0.4-0.6, grease medical - other (see RF patent №2091065, a 61 K 9/06, a 61 K 35/78, publ. 1997).

Known ointments for the treatment of psoriasis, one of which contains fresh egg white, honey, baby cream, vitamin E part, cedar oil, tar, medical, grease technical, and other fresh egg white, cream, baby powder, herbs celandine, honey bee, tar medical, grease technical in certain proportions, and to ensure also used the biologically activeevent in tincture form zamanihi, or Siberian ginseng, or Golden root, or Rhaponticum carthamoides, or Manchurian aralia in the amount of 30-40 drops 3 times a day 30 minutes before meals (see RF patent №2077319, a 61 K 31/00, a 61 K 35/78, publ. 1997).

Known ointment, composed of a mixture of vaseline, lanolin and biologically active substances - fir oil and aqueous extract of Siberian fir in certain proportions (see RF patent №2074730, a 61 K 35/78, publ. 1997).

Closest to the proposed ointment is used mainly for the treatment of purulent-necrotic disease of the limbs of animals, representing the ointment of the following composition, wt.%: veterinary copper sulphate 7.5 to 15; birch tar, 9,0-13; Ichthyol 3-5; vaseline - other (see RF patent №2025110, IPC And 61 D 7/00, a 61 K 31/00, publ. 1994 - prototype).

Ointment used for the treatment of purulent-necrotic disease of the limbs with the duration of exposure from 3 to 10 days. In addition, the ointment may further comprise a wagotilom and/or cubital from 4 to 7% in severe form of the disease. The ointment can be pre-prepared by mechanical mixing of these components in the above percentage at a temperature of 36-40°C. Ointment time-consuming to manufacture, requires heating at the time of its preparation, which increases its value.

The effect of the ointment is not effective: low anti-Christ. especially effect low penetrating power. Known ointment, like most other counterparts, it has a specific action in a particular disease.

Common disadvantages of these ointments (analogs and prototypes) are high complexity and duration of receipt. In addition, these ointments are not the drugs of a wide range of therapeutic effects, i.e. not universal and applicable for the treatment of only certain of the above diseases, mnogokomponentnye that impact overall on their toxicity, cost, and complexity of production.

The technical result of the invention to create a simple, versatile, cost effective, non-toxic ointments wide spectrum of therapeutic action of low available functionality and low cost, without antibiotics, for the treatment of various diseases of humans and animals that have a long shelf life, easy to use and provides the reduction of treatment time. Additionally achieves ease of production and high cost of creating a stable composition of ointment of products of natural origin.

The technical result is achieved by the fact that anti-inflammatory ointment, including birch tar, and petroleum jelly, further comprises a liquid potassium HUMATE and sodium silicate when following their ratio, m is S.%:

liquid potassium HUMATE6,5-10
birch tar4-7
sodium silicate3,5-6
vaselinethe rest of it.

It is preferable to apply a liquid HUMATE potassium content of humic substances is not less than 4.5 g/L.

The invention is in the selection of such a component ratio of the ointment that creates the most complete and powerful reserve for the action of biologically active substances, and the matching ointment base facilitates the efficient exit of these substances and their penetration into tissue when applying on the skin.

In the patent and scientific literature unknown solutions matching proposed in all essential features, which allows to make a conclusion on the conformity of the proposed drug for the condition of patentability "novelty", Only the combination of the stated components in specific amounts to achieve the specified technical result of the invention. Component selection ointments and include humanitarias and silicon-containing components in a certain ratio allowed us to get a subtle effect, which is not shown in case of separate components that are included in the MAZ is, to accelerate and improve healing sick people and animals, reduce the complexity and cost of the treatment of a wide spectrum of diseases, i.e. the proposal meets the criterion of "inventive step".

The ointment is applied in medicine for the treatment of diseases such as psoriasis, arthrosis, arthritis, corns, sores, dermati, herpes and others, in veterinary medicine for the treatment of eczema, dermatitis, necrotic disease of the limbs of animals, such as microbatteries, purulent pododermatitis, laminate, pricked over, cuts, swelling of limbs, hooves, as well as the prevention and treatment of mastitis, because it meets the condition of patentability "industrial applicability".

The ointment is used as follows. In medicine and veterinary medicine for the treatment of the proposed ointment has the following composition, wt.%: HUMATE potassium 6.5 to 10; birch tar 4,0-7,0; silicate of sodium 3,5-6,0; petrolatum else. The period of medical procedures from 3 to 40 days. Duration of treatment set depending on the volume of the lesion, the disease, its clinical signs. This composition improves the efficiency ointments and expand its scope.

The ointment can be prepared at room temperature before its application or in advance. The ointment is prepared by simple mixing of the components in a given proporz and at room temperature. For example, 1 kg of vaseline applied to 100 g of liquid potassium humates (TU 0392-001-57401948-03) with a pH of 10-12, 50 g of birch tar (P 70.421.2), 50 g of sodium silicate (liquid sodium glass according to GOST 13078-81). The shelf life of the resulting ointment for at least 6 months. Parameters ointment stable during storage. The ointment is an elastic mass of dark color with a specific smell of tar.

In the preparation of liquid potassium HUMATE in the ointment basis under the influence of mechanical mixing enables education in a mixture of new substances, which when the outer overlay ready ointments on the affected area of the body creates anesthetic barrier that enhances therapeutic efficacy of the composition. The proposed solution allows to obtain a inexpensive, cost-effective ointment with high efficiency in the treatment of a wide spectrum of diseases in humans and animals, as well as to reduce the treatment time. therapeutic effect of the ointment tested in the whole range of quantitative content components. Complications and side effects in the use of materials not identified.

Prototypes of the proposed ointments were studied in different groups of sick people and animals with diseases of different etiology. The use of sunscreen effectively for a number of common diseases of humans and animals, which provides in General because the applicability and versatility of the ointment.

Example 1. At the dairy farm cows detected initiates on a limb of the animal. The treatment was carried out by dressing individual foot bandages to apply the ointment of the following composition, wt.%: liquid potassium HUMATE 7, birch tar, 6; sodium silicate 6, petrolatum else. The ointment is prepared by mechanical mixing of these substances at room temperature (20-30°). A bandage fix, animal releases and does not restrict movement. Bandage therapeutic drug was incubated for 2-3 days, then remove. As a result, the affected area was formed granulation tissue, appeared thrust reflex on the affected limb.

Example 2. On the hooves of cows detected swelling caused by a cut, the animal behaves nervously. The treatment is carried out analogously to example 1. The duration of treatment 6 days. After removal of the individual bands of the affected limb is fully restored. The animal is active, the lameness disappeared, normalized overall condition.

Example 3. In the private sector cows identified mastitis. Rubbing the proposed ointment for 14 days in complex antimastit treatment significantly reduce the number of inflamed sites, reduce inflammation, and provide softness of the udder, to increase milk output.

For a broad Ave is use in veterinary practice, we offer the ointment was tested for the treatment of tumors of the hoof, and Nikolov and small wounds on the hoof during the period of grazing animals cattle, cow dairy herd SEC "Rus" and Novoselki" the Ryazan region. Control was Ichthyol ointment (traditional medication for the treatment). In the SEC "Rus" were selected on 5 cows in each case. Novoselki" 40 cows had a sore hoof with the clinic: pricked over, cuts, swelling. In the control group was 18 goals in the test - 22.

The proposed ointment was applied on the cleaned hoof and was bandaged. The bandage of the hooves of the cows was performed after 2 days. The positive effect of the ointment on the basis of potassium humates disease hooves of cows manifested through 6-7 days. The cost of treatment of one's head in the control group of cows the traditional method for the occasional consumption of 20-30 grams Ichthyol ointment on one ligation 30-45 per course of treatment. Action Ichthyol ointment was shown at 10-12 days. The cost of treatment offered gumanoy ointment at the same application rates for treatment of 2,4-3,6 rubles, i.e. almost 12 times cheaper, and treatment gumanoy ointment is 1.5-2 times faster.

The use of the claimed ointment in veterinary medicine will improve the efficiency of meat and milk cattle breeding, excludes forced slaughter of productive animals. The obvious advantage of speed of impact is of major. However, the drug is available, acceptable cost, easy to use, its reproduction requires a minimum of tools and effort compared to existing drugs, using scarce expensive components. The treatment efficiency is achieved over a short period of time.

For medical use of the ointment was tested on human volunteers, it was noted that, possessing anti-inflammatory, antimicrobial action, it is in addition to the specified destination (psoriasis, arthrosis, arthritis) can be effectively used in the treatment of dermatological diseases and other inflammatory processes, such as cold sores, bedsores after surgery, corns. The ointment is applied topically by lightly rubbing into the affected area 1-2 times daily until recovery.

Examples confirm protivoraketami anesthetic ointment in inflammatory diseases.

Example 1. Patient N., 70 years, diagnosed with osteoarthritis of the knee. Within two years, systematically carried out by local treatment of various means of domestic production "Astin", "Sophia", the duration of which is to reduce pain syndrome during periods of exacerbation of the disease at least 7-10 days.

After applying the ointment for 5 days in a period of severe exacerbation, virususe the Osia in difficulty of movement without pain, severe lameness, complaints of poor sleep, the patient pain, lameness, normalized sleep, restored health. The proposed ointment was topically applied daily 1 time per day.

Thus the ointment in this disease has a good analgesic and anti-inflammatory effect that reduces the time of treatment and recovery of joint function with good tolerability of the treatment.

Example 2. Patient P., 76 years 5 years periodically outpatient treated because of the pain is a deep, dry calluses on the feet, accompanied by lameness. Was prescribed various creams and protivopozarnyi patch "Sliped". The application of the proposed ointment for 5 days by rubbing 1-2 times daily in the affected area had analgesic anti-inflammatory effect. Went limp, re-performance.

Example 3. Example 3. A female patient, 72 years, for 12 years suffered from psoriasis with extensive involvement of the skin of the hands. Repeatedly treated as outpatients and in stationare, using well-known methods of treatment, noting the short-term improvement of health. Complaints, irritability, itching, bad dream. The proposed ointment was applied topically on the affected areas 1-2 times a day. 7 days after smearing was observed prosvetlenie the lesion. Treatment in ECENA 4 weeks has significantly improved the condition of the patient. The skin is cleansed, there was a sharp decrease in itching, normalized sleep. The drug was provided in psoriasis, anti-inflammatory, antipruritic, keratolytic action, contributed to the decrease in infiltration, the regression of dermal elements, had expressed protivoraketami analgesic action.

Presents clinical data proves the effectiveness of the drug for psoriasis. Considering the obtained data, the ointment should be applied topically, applying twice a day in sufficient quantity to completely cover the affected area, within 20-40 days. The effect of the application of the ointment fast enough, contraindications have not been identified, treatment for chronic forms of the disease can be repeated. The method of applying the ointment is simple, less time-consuming available. The ointment can be applied both in the inpatient and outpatient practice.

Positive results about the healing properties of the ointment in the field of dermatology allow to draw a conclusion about the possibility of its wide application in the field of medicine.

Ointment on the basis of potassium HUMATE is composed of components having bactericide, anti-inflammatory and analgesic properties. All components are of natural origin without chemical additives. This widespread use is due Leka is the only value ointments due to the optimal combination in it of biologically active substances and silicon dioxide.

Tar has antiseptic antiseptic action, improves circulation in the tissues, stimulates and strengthens the processes of keratinization. Has absorbing effects in chronic inflammatory processes.

The mechanism of action of potassium humates associated with redox functions in the body, activation of metabolic processes, protein synthesis and carbohydrate effects on bioenergetic processes in the body. Humates adsorbed on the cell wall, increasing its elasticity and stimulate cell regeneration processes, contribute to the improvement of metabolic processes.

Silicon dioxide has a positive effect on the metabolism in the body, phosphorus, chlorine, sulfur, molybdenum, manganese, cobalt, and also inhibits the absorption of toxic elements strontium, cadmium, aluminum.

A positive effect of silicon dioxide on the biosynthesis of protein. The lack of in the body of silicon dioxide leads to the development of some animals dermatitis. In animals there are cracks on kopitam the horn, the appetite, the regrowth of the woolen cover. Compounds of silicon dioxide has a positive effect on the elasticity of the hair of animals. Compounds of silicon dioxide play an important role in the removal of the gastrointestinal tract of various toxic substances. Silica provides the t best use animals nitrogen feed.

Use the ointment with the proposed structure provides both an antiseptic and regenerating effect on the diseased tissue of the human or animal. The use of liquid humates in combination with such drugs as tar, vaseline, sodium silicate eliminates irritating ointments on the affected part of the body.

Thus, the proposed ointment can be used in medical and veterinary practice. Its preparation is quite simple. For the manufacture of ointments used available raw materials. The treatment of this ointment reduces the treatment time, in addition, ointment stable in composition and has no chemical or special synthetic additives.

The positive effect of the ointment is the versatility, high efficiency, cost accessibility to treatment and unlimited resource base. According to experimental results of the application of ointments can be seen that it is superior to known drugs of a wide range of actions cost, simplicity, security, preparation and is not inferior to them in terms of storage and treatment of various skin diseases of humans and animals. The versatility of ointments, ease of preparation, low cost, the possibility of treating various inflammatory diseases in animals and humans suggest that the ointment can find a wide PRA the political use in the treatment at home in hospitals, in the field.

1. Anti-inflammatory ointment, including birch tar, and petroleum jelly, characterized in that it further comprises a liquid potassium HUMATE and sodium silicate when following their ratio, wt.%:

Liquid potassium HUMATE6,5-10
Birch tar4-7
Sodium silicate3,5-6
VaselineRest

2. The ointment according to claim 1, characterized in that the applied liquid potassium HUMATE humic substances is not less than 4.5 g/L.



 

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3 ex, 4 tbl

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of indole of the formula (1): and their pharmaceutically acceptable salts wherein represents a double bond; Z1 represents nitrogen atom (N), -CR5 wherein R5 represents hydrogen atom (H), (C1-C6)-alkyl, hydroxy-group (OH),(C1-C6)-alkoxy-group or halogen atom; Z2 at position 2 represents CR1 and at position it represents CA wherein each R1 means independently (C1-C6)-alkyl; A represents -Wi-COXjY wherein Y means -COR2 wherein R2 means -OR, -NR2, -NRNR2 or -NROR wherein each R represents independently hydrogen atom (H), (C1-C6)-alkyl, or (C5-C6)-heteroaryl comprising one or two heteroatoms in ring chosen from atoms N, O and S wherein each of them is substituted with one or some groups chosen from -NR'2, -OR', -COOR', (C1-C6)-alkyl, -CN, =O, and -SR' wherein each R' represents hydrogen atom (H) or (C1-C6)-alkyl and wherein two R or R' jointed to the same nitrogen atom (N) can form 3-8-membered ring chosen from the group comprising piperazine ring, morpholine ring, thiazolidine ring, oxazolidine ring, pyrrolidine ring, piperidine ring, azacyclopropane ring, azacyclobutane ring and azacyclooctane ring and wherein indicated ring can be substituted additionally with (C1-C6)-alkyl or -COO-(C1-C6)-alkyl; X represents unsubstituted (C1-C6)-alkylene, or Y means imidazole substituted with methyl group; i = 0; j = 0 or 1; R7 means hydrogen atom (H) or (C1-C6)-alkyl, -SOR, -SO2R, -RCO, -COOR, (C1-C6)-alkyl-COR, -CONR2, -SO2NR2,-CN, -OR, (C1-C6)-alkyl-SR, (C1-C6)-alkyl-OCOR, (C1-C6)-alkyl-COOR, (C1-C6)-alkyl-CN, or (C1-C6)-alkyl-CONR2 wherein each R represent independently hydrogen atom (H), (C1-C6)-alkyl or aryl that is substituted optionally with halogen atom, (C1-C4)-alkyl or (C1-C4)-alkoxy-group; or R7 represents methoxymethyl, methoxyethyl, ethoxymethyl, benzyloxymethyl or 2-methoxyethyloxymethyl; each R3 represent independently halogen atom, (C1-C6)-alkyl, -OR, -SR or -NR2 wherein R represents hydrogen atom (H) or (C1-C6)-alkyl; n = 0-3; L1 means -CO; L2 means (C1-C4)-alkylene optionally substituted with one or two groups of (C1-C4)-alkyl; each R4 is chosen independently from the group comprising (C1-C6)-alkyl, halogen atom, -OR, -NR2, -SR, -SOR, -SO2R, -RCO, -COOR, -CONR2, -SO2NR2 wherein each R represents independently hydrogen atom (H) or (C1-C6)-alkyl; or R4 represents =O; m = 0-4; Ar means aryl group substituted with from 0 to 5 substitutes chosen from the group comprising (C1-C6)-alkyl, halogen atom, -OR, -NR2, -SR, -SOR, -SO2R, -RCO, -COOR, -CONR2 and -SO2NR2 wherein each R represents independently hydrogen atom (H) or (C1-C6)-alkyl. Compounds of the formula (I) possess the inhibitory activity with respect to p38-α kinase that allows their using as components of the pharmaceutical composition.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.

63 cl, 3 tbl, 9 sch, 16 ex

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: the suggested preparation for treating inflammatory skin diseases contains mud volcano mud as an active substance to be introduced into polymeric mixture, moreover, the mud should be introduced into swollen polymers during mixing and homogenization till the development of homogeneous gel mass at the ratio of 15-30:1.5-2.5 in weight portions, and, also, a conservant and a pharmaceutically acceptable solvent. Additionally, the preparation contains plant and/or mineral oils and an emulsifier.

EFFECT: higher efficiency of therapy.

4 cl, 4 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a soluble, carbonated, anti-inflammatory, analgesic and antipyretic agent as a tablet. Agent comprises acetylsalicylic acid, caffeine, ascorbic acid, paracetamol, basic component, acidic component and accessory substances. Invention provides the possibility of rapid release of the preparation in blood, decreasing time for undesirable contact of the preparation with stomach mucosa and its high activity.

EFFECT: valuable medicinal and pharmaceutical properties of agent.

6 cl, 6 tbl, 11 ex

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an anti-inflammatory ointment with hypolipidemic effect. Proposed ointment comprises ephthylline-base for ointment, a statin wherein lescol (fluvastatin) is used as statin, and ephthylline comprises 40% of ephthiderm. Invention provides enhancing the curative effect and hypolipidemic effect and effects on enzymatic systems of biological membranes that results to prolongation of curative effect of ointment.

EFFECT: valuable medicinal properties of ointment.

3 cl, 2 tbl

FIELD: medicine, cardiology, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to an agent used in treatment and prophylaxis of cardiovascular diseases. The claimed agent comprises the following components, wt.-%: foridone as an active substance (3.00-6.00) and pharmaceutically acceptable carrier - gel base (the balance) consisting of a thickening agent, non-aqueous hydrophilic solvents, hydrophobic solvents, preserving agent, neutralizing agent, emulsifier and purified water. Invention provides achievement of high level of prolongation of specific activity of agent, reducing or excluding negative adverse effects.

EFFECT: improved and valuable medicinal properties of agent.

8 cl, 5 tbl, 14 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a composition comprising one or more corticosteroids and/or hormonal steroids in the range from 0.025 to 5 wt.-% of the total composition mass and hyaluronidase in the amount from 25 to 4000 UTR per 1 g of the composition in the suitable carrier medium. The composition can comprise nonhormonal anti-inflammatory agents. The composition can be prepared in different medicinal formulations, such as gel, ointment, cream, aerosol with additives known from a person skilled in the art of the corresponding field. Betamethasone is the preferable corticosteroid. Ointment is the preferable medicinal formulation. Treatment by using corticosteroids in combination with hyaluronidase provides the improvement of state in 90% of patients, and after their treatment their prepuce can be drawn off easily.

EFFECT: improved medicinal properties of composition, enhanced effectiveness of treatment.

11 cl, 6 ex

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to creating drugs for treatment and prevention of inflammatory lesions of support-motor apparatus (myosites, arthrites, tendovaginites, etc.). Therapeutical composition according to invention contains, wt %: essential oil of silver fir 1.0-2.0, camphor 4.0-5.0, oil extract of red capsicum 0.06-0.08, biologically active component isolated from medicinal leech or its parts 0.01-6.5, Ibuprofen 60.0-65.0, ethoxydiglycol 3.0-5.0, Emulgin B2 0.4-0.6, Carbomer 0.5-0.8, triethanolamine 0.6-0.8, methylparben 0.2-0.3, propylparben 0.02-0.03, butyloxyanisol 0.08-0.1, Bronopol 0.04-0.05, and water the rest. Composition activates metabolic processes in skin and subcutaneous fat layer, normalizes blood supply, eliminates stagnant phenomena, accelerates getting active therapeutical substances into membranes of biological cells, which results in rapid achievement of stable therapeutical effect in what concerns elimination of inflammatory process in joints and muscles.

EFFECT: increased therapeutical efficiency.

2 tbl

FIELD: pharmaceutical industry and cosmetics.

SUBSTANCE: composition contains, wt %: biologically active component isolated from medicinal leech or its parts 0.01-6.0, menthol 0.15-0.25, aqueous-alcoholic extract of horse-chestnut fruitage 8-10, camphor 0.15-0.30, ethoxydiglycol 3-5, polyethyleneglycol 1500, 0.8-1.2, emulgin B2, 0.8-1,2, Carbomer 0.6-0.8, triethanolamine 0.6-0.8, methylparben 0.25-0.35, Bronopol 0.04-0.06, butyloxyanisol 0.06-0.08, and water to 100%. Composition is made in the form of gel and provides antithrombic and analeptic effects on skin and hypodermic tissues, enhances antiinflammatory action, favors deep penetration of active components through skin, strengthens venous vessel walls, improves microcirculation of blood, and accelerated restoration of vascular wall tone.

EFFECT: expanded therapeutical possibilities.

2 cl, 2 tbl

FIELD: pharmaceutical chemistry.

SUBSTANCE: agent contains active components foridonum (3.00-6.00%) and isosorbide dinitrate (3.00-6.00%) with pharmaceutically acceptable gel base. The latter is composed of thickener, non-aqueous hydrophilic solvents, hydrophobic solvents, preservative, neutralization agent, emulsifier, and purified water.

EFFECT: increased bioavailability of active components and reduced or suppressed negative side effects such as locally irritating effects.

9 cl, 3 tbl, 14 ex

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an anti-inflammatory ointment with hypolipidemic effect. Proposed ointment comprises ephthylline-base for ointment, a statin wherein lescol (fluvastatin) is used as statin, and ephthylline comprises 40% of ephthiderm. Invention provides enhancing the curative effect and hypolipidemic effect and effects on enzymatic systems of biological membranes that results to prolongation of curative effect of ointment.

EFFECT: valuable medicinal properties of ointment.

3 cl, 2 tbl

FIELD: cosmetology, esthetic surgery, applied biopharmacology.

SUBSTANCE: invention relates to medicative and cosmetic agents, and uses of biologically active substances based on natural biological complexes. Claimed method includes application of Mirralgin balm having analgesic, anti-inflammation and resolving action, Reventon balm, having vessel restorative action, for edema reducing and microcirculation improving. In process of blepharoplastic eye boundary bandage microemulsion having recovery and animative action on eaves skin is applied, and in process of facelifting cream mask having bactericide, vessel restorative and recovering action, and enhancing of local immunity is applied. Mirralgin balm and Reventon balm treatment is carried out sequentially or alternatively. In another embodiment after skin cleaning and treatment of damaged zone with anti-septic agent Bacteriophage gel, which disinfects skin surface, prevents biofilm forming, accelerates cicatrizing process is applied, then posttraumatic zone is treated with cleaning milk, toned up with tonic lotion and cream mask having bactericide, vessel restorative and recovering action, and enhancing of local immunity is applied.

EFFECT: method for skin structure recovering without skin trauma.

4 cl, 7 ex, 1 tbl

FIELD: veterinary science, medicine, pharmacy.

SUBSTANCE: invention relates to agents used in treatment of dermatomycosis in animals and humans. Ointment for treatment of dermatomycosis in animals and humans comprises acetylsalicylic acid, 5% iodine alcoholic solution and glycerol taken in the definite ratio of components. Invention enhances effectiveness of treatment, decreases time in treatment of dermatomycosis and prevents appearance of new foci of diseases and relapses.

EFFECT: enhanced effectiveness of treatment.

6 ex

FIELD: medicine, contraception.

SUBSTANCE: invention proposes antibacterial and contraceptive compositions that comprise the following components: (1) matrix-forming substance; (2) bioadhesive substance; (3) buffer substance; (4) moistening substance, optionally; (5) preserving agent, optionally, and (6) water. Proposed compositions are suitable for their placement into vagina wherein compositions form semisolid matrix in contact with testicular fluid, cause thickening cervical mucus, form a bioadhesive layer on vagina surfaces, maintain the natural acid pH value in vagina about less 5 in the presence of testicular fluid ejected by a male and don't disturb essentially the natural microbiological balance in vagina. Compositions and methods decrease and/or prevent transfer of diseases transferring by sexual way and act as vaginal contraceptives with less adverse effect as compared with conventional vaginal contraceptives and can be used therefore for a long time. Compositions and methods are simple for using and don't require a physical device for their retention into vagina during using.

EFFECT: improved and valuable properties of compositions and methods.

36 cl, 17 tbl, 11 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to an agent for topical using used in treatment of joint diseases. The proposed agent comprises glucosamine salt, chondroitin sulfate and dimethylsulfoxide incorporated into an acceptable ointment base. Invention provides enhancing effectiveness due to using low-molecular saccharides that results to elevating diffusion delivery rate of the substance to the joint zone and providing the achievement of synergistic effect in treatment of joint diseases.

EFFECT: enhanced effectiveness and valuable medicinal properties of agent.

2 cl, 3 ex

FIELD: perfumery-cosmetic industry.

SUBSTANCE: the present innovation deals with different compositions of tooth pastes. The suggested tooth paste with whey contains an abrasive, a structure-forming agent, a moisturizer, a surface-active substance, a whitening additive and functional additives and water, moreover, as whitening additive it contains whey; components should be taken at a certain quantitative ratio. The suggested tooth paste enables to widen the assortment of tooth pastes supplemented with whitening additives.

EFFECT: higher efficiency of application.

5 cl, 2 ex

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