Anti-parasitic preparation

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with preventing and treating diseases caused by animal endoparasites. Anti-parasitic preparation contains closantel or its sodium salt dissolved in the main solvent as polyethylene glycol, propylene glycol, triethylene glycol or their mixtures, the suggested preparation contains, also, novocain (or lidocain, or anaesthesin), ethanol and/or isopropyl alcohol, polyvinyl pyrrolidone, benzyl alcohol and water at certain ratio of components. The innovation provides high efficiency of anti-parasitic action at no pain and inflammatory reaction in animals both at intramuscular and subcutaneous types of injection, moreover, decreased milk yields in cows haven't been observed.

EFFECT: higher efficiency.

1 cl, 96 ex

 

The invention relates to the field of veterinary medicine and can be used for the prevention and treatment of diseases caused by endoparasites of animals, in particular worms.

Known agents for combating parasites of animals active substance which is closantel mixed with benzimidazole derivatives (patent RU 2140267, 1999), avermectins (patent RU 2129430, 1999), with milbemycin (NZ patent 248486, 1993). Solvents such drugs, as a rule, serve as polyethylene glycol or propylene glycol.

Known antiparasitic agent, an active substance which is a sodium salt of closantel and solvents - a polyalcohol and/or their esters, including mixtures with water (patent FR 2739778, 1997).

In the patent US 6340672, 2002, described antiparasitic agent, in which the preferred active substances are closantel and ivermectin, and as solvents can be used derivatives of pyrrolidone and propylene glycol.

All of the above preparations auxiliary components are selected to maintain the dissolved one or more active substances. About other properties and functions of auxiliary component data not shown.

The disadvantage of existing drugs (known as santel, rolena, closeness) is strong over the th and inflammatory response in animals as intramuscular, and after subcutaneous administration of drugs. It is expressed in a restless animal behavior, swelling at the injection site. In cows for a while markedly reduced milk production.

The proposed tool for greater efficiency antiparasitic action allows you to virtually eliminate the above drawback.

According to the invention antiparasitic agent for the prophylaxis and treatment of animals contains closantel or its sodium salt, dissolved in a primary solvent, which mainly use polyethylene glycol (low molecular weight polyethylene oxide), propylene glycol, triethylene glycol or mixtures thereof. In addition, the product contains procaine, ethyl alcohol or isopropyl (or their mixture), polyvinylpyrrolidone and water in the following ratio of components:

closantel5-40 g/100 ml
an anaesthetic substance0.5 to 3.0 g/100 ml
the ethyl and/or isopropyl20-35% vol.
water10-30% vol.
the main solventrest

Additionally antiparasitic agent may contain benzyl alcohol in an amount of 3-6%. and/or polivi iparralde in the amount of 0.5-1.0 g/100 ml

In the above structure of ethyl alcohol and water serve as auxiliary solvents, lowering the viscosity of the mixture. In addition, ethyl alcohol and benzyl alcohol have a sterilizing effect. The inclusion of novocaine can dramatically reduce the pain response of the animals. Polyvinylpyrrolidone and benzyl alcohol stabilize antiparasitic agent in General.

Information confirming the possibility of carrying out the invention

Example 1. To obtain 1 DM3antiparasitic remedies prepared a mixture of solvents, which took glycol - 500 cm3, ethyl alcohol 96%-95 cm3, isopropyl alcohol - 200 cm3, benzyl alcohol - 35 cm3water - 160 cm3. The mixture was thoroughly mixed, introduced 10 g polyvinylpyrrolidone, 10 g of procaine hydrochloride and again thoroughly mixed to dissolve the components. A portion of 100 g of closantel suspended in 800 ml of prepared mixture dropwise and with vigorous stirring was added 6 g of NaOH in the form of a 50% solution.

The dissolution is conducted in a water bath heated to a temperature of 35-40°C. After cooling brought the volume up to 1 DM3the remaining mixture of solvent and thoroughly mixed (the density of 1.09). Obtained the means hereinafter for brevity denoted by 10% KN (10% closantel + 1% procaine). Funds received the same about what atom, but with a different content closantel, in the examples below, marked 5% KN and 15% of the book.

Example 2. In disadvantaged by fasciolosis farming method coproscopy were selected 14 cows with spontaneous fasciolosis. 11 animals was introduced 10% KN-in

a dose of 0.5 ml/20 kg (2.5 mg/kg of DW) of body weight once (6 animals subcutaneously, 5 intramuscularly). As the comparison drug three cows were injected once subcutaneously 10% santel at a dose of 0.5 ml/20 kg (2.5 mg/kg of DW) of body weight.

After subcutaneous and intramuscular means of pain response in cows is not mentioned. After subcutaneous administration of 10% KN two out of six cows in 30 min was noted education minor swelling (2×4 cm), which was held over 3 days. Intramuscular injection of 10% KN none of the five cows were not noted any local reaction.

After subcutaneous administration of santel three cows was marked by a strong pain reaction, expressed strong concern animals, which was hard to capture. Two out of three cows, which were introduced santel, at the injection site formed a swelling the size of 1 day 6×8 cm, 2 day 7×10 cm, which was held over four days.

According to coproscopy efficiency 10% KN fascioliasis in subcutaneous and intramuscular amounted to 91%. The effectiveness of santel after subcutaneous administration was R who ate 67%.

Example 3. In laproscopically studies were selected 30 sheep infected with F. hepatica. Animals of the 1st group (15 goals) has introduced a 10% KN-10 in a dose of 1 ml/20 kg (5 mg/kg of DW) of body weight subcutaneously; sheep 2-nd group (10 animals) introduced santel at a dose of 1 ml/20 kg (5 mg/kg of DW) of body weight subcutaneously; group 3, consisting of 5 sheep, deworming were not exposed and served as a control.

The results coproscopic survey EE (extendedrequest) 10% KN was 85,8%, the helminthological opening EE - 80%; IE - 88%.

Santel after a single subcutaneous injection at a dose of 5 mg/kg) DW showed according to coproscopy efficiency equal to 80%, according to the results of the opening 82%.

Example 4. Picked up three groups of cattle, spontaneously infested fasciolas. The first group of 10 animals was injected the drug 5% SC at a dose of 1 ml/20 kg (2.5 mg/kg of DW) weight of the animal (5 animals subcutaneously, 5 animals intramuscularly); the second group entered rolena dose of 1 ml/20 kg (2.5 mg/kg of DW) weight of the animal (5 animals subcutaneously, 5 animals intramuscularly); the third group in the amount of 5 goals was without processing. Effectiveness was determined by the method of successive washings faeces 5; 10; 15; 25; 35 and 45 days after drug injection.

With the introduction of rolerole watched more concern of the animal than would the drop 5% of the book.

It is established that the introduction of 5% KN both ways extendedrequest drug was 100%, at the same time, by intramuscular, and subcutaneous injection of rolerole the effectiveness of, respectively, 100%and 80%.

Example 5. According to laproscopically studies, we selected three groups of sheep on three heads each, spontaneously infested F. hepatica. Animals of the first group has introduced a 5% SC at a dose of 1 ml/10 kg body weight intramuscularly; the animals of the second group - 5% rolena dose of 1 ml/10 kg body weight intramuscularly; the third group was no treatment and served as control.

As a result complete helminthological opening experimental and control animals 20 days after injection into the lumen of the ducts and the liver parenchyma fasciolae not detected, i.e. the efficiency of 5% KN and 5% rolename was 100%. Animals of the control group at autopsy were found living of Fasciola.

Example 6. Selected three groups of sheep infected with F. hepatica, 5 goals each. Animals of the first group introduced a 15% SC at a dose of 0.66 ml/20 kg (5 mg/kg of DW) of body weight intramuscularly; sheep of the second group has introduced a 5% closeness dose of 1 ml/10 kg (5 mg/kg of DW) of body weight; the third group of sheep worming is subjected.

According to the results of a complete helminthological opening efficiency 15% KN and 5% closeness fascioliasis was 100%

Example 7. To obtain antiparasitic remedies mixed with 240 g (300 ml) ethyl alcohol 96%, 305 ml of polyethylene oxide-400, of 36.4 g (35 ml) of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-45° to dissolve closantel. Then introduced 10 g of benzocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the remaining mixture of solvents and mixed.

Example 8. To obtain 1000 ml of antiparasitic remedies mixed with 160 g of closantel sodium with 240 g (300 ml) ethyl alcohol 96%, 490 ml of polyethylene oxide-400 (polyethylene glycol), of 36.4 g of benzyl alcohol and mixed until dissolved, then made 10 g polyvinylpyrrolidone, 5 g of lidocaine, 160 ml of water and again thoroughly mixed. The dissolution is conducted at a temperature of 35-45°. After ohlazheniya volume was brought to 1000 ml of the primary solvent and thoroughly mixed.

Example 9. To obtain 1000 ml of antiparasitic remedies prepared a mixture of solvents, which took 365 ml of polyethylene oxide-400, 300 ml of ethanol, 35 ml of benzyl alcohol, 160 ml of water. The mixture was mixed, introduced 10 g polyvinylpyrrolidone, 15 g of novocaine and again thoroughly mixed to dissolve the components. A portion of 400 g of closantel suspended in 800 ml of prepared mix and what about the drops under vigorous stirring was added 24 g of NaOH in the form of a 50% solution. The dissolution is conducted in a water bath heated to a temperature of 35-40°C. After cooling brought the volume up to 1000 ml with a mixture of solvent and thoroughly mixed.

Examples 10-11. Prepared 2 composition as in example 9, but containing procaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 12. To obtain 1000 ml of antiparasitic funds took 500 ml polyethylene oxide-400, 300 ml of ethanol, 35 ml of benzyl alcohol, 160 ml of water. The mixture was mixed, introduced 10 g polyvinylpyrrolidone, 10 g of novocaine and again thoroughly mixed to dissolve the components. A portion of 50 g closantel suspended in 800 ml of prepared mixture dropwise and with vigorous stirring was added 3 g of NaOH in the form of a 50% solution. The dissolution is conducted in a water bath at 35-40°C. After cooling brought the volume up to 1000 ml with a mixture of solvent and thoroughly mixed.

Examples 13-14. Prepared 2 composition as in example 12, but containing procaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 15. To obtain antiparasitic funds took 460 ml of polyethylene oxide-400, 300 ml of ethanol, 35 ml of benzyl alcohol, 160 ml of water. The mixture was mixed, introduced 10 g polyvinylpyrrolidone, 15 g of novocaine and again thoroughly mixed to dissolve the components. A portion of 100 g of closantel suspended in 800 ml of prepared mixture and dropwise with intensive lane is mesheanii added 6 g of NaOH in the form of a 50% solution. The dissolution is conducted in a water bath at a temperature of 35-40°C. Cooled, brought the volume up to 1000 ml with a mixture of solvent and thoroughly mixed.

Examples 16-17. Prepared 2 composition as in example 15, but containing procaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 18. To obtain 1000 ml of antiparasitic remedies prepared a mixture of solvents, which took 420 ml of polyethylene oxide-400, 300 ml of ethanol, 35 ml of benzyl alcohol, 160 ml of water. The mixture was mixed, introduced 10 g polyvinylpyrrolidone, 15 g of novocaine and again thoroughly mixed to dissolve the components. A portion of 200 g closantel suspended in 800 ml of prepared mixture dropwise and with vigorous stirring was added 12 g of NaOH in the form of a 50% solution. The dissolution is conducted in a water bath heated to a temperature of 35-40°C. After cooling brought the volume up to 1000 ml with a mixture of solvent and thoroughly mixed.

Examples 19-20. Prepared 2 composition as in example 18, but containing procaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 21. To obtain 1000 ml of antiparasitic funds took 200 ml of isopropyl alcohol, 520 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g Pelevin is pyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 22-23. Prepared 2 composition similar to the previous example, but containing 300 ml of isopropyl alcohol and 420 ml of polyethylene oxide-400 in one case and 350 ml of isopropyl alcohol and 370 ml of polyethylene oxide-400 in the other.

Example 24. To obtain antiparasitic remedies prepared a mixture of solvents, which took 200 ml of isopropyl alcohol, 520 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 25-26. Prepared 2 composition as in the previous example, but containing 300 ml of isopropyl alcohol and 420 ml of propylene glycol in one case and 350 ml of isopropyl alcohol and 370 ml of propylene glycol in the other.

Example 27. To obtain antiparasitic remedies prepared a mixture of solvents, which took 200 ml of isopropyl alcohol, 500 ml polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath in temp is the temperature of 35-40° C to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. Cooled, brought the volume up to 1000 ml of the primary solvent and mixed.

Examples 28-29. Prepared 2 composition as in the previous example, but containing 300 ml of isopropyl alcohol and 400 ml of propylene glycol in one case and 350 ml of isopropyl alcohol and 350 ml of propylene glycol in the other.

Example 30. To obtain 1000 ml of antiparasitic funds took 200 ml of isopropyl alcohol, 405 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 31-32. Prepared 2 composition as in the previous example, but containing 300 ml of isopropyl alcohol and 305 ml of polyethylene oxide-400 in one case and 350 ml of isopropyl alcohol and 255 ml of polyethylene oxide-400 in the other.

Example 33. Took 300 ml of ethyl alcohol, 285 ml of polyethylene oxide-400, 60 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then wnek is 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 34. To obtain antiparasitic funds took 300 ml of ethyl alcohol, 395 ml of polyethylene oxide-400, 60 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 35. To obtain antiparasitic remedies prepared a mixture of solvents, which took 300 ml of ethyl alcohol, 380 ml of polyethylene oxide-400, 60 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 36. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol, 375 ml of polyethylene oxide-400, 60 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40° C to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 37. Antiparasitic agent was prepared, taking 180 ml of ethanol, 120 ml of isopropyl alcohol, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 38. To obtain antiparasitic funds took 180 ml of ethanol, 120 ml of isopropyl alcohol, 420 ml of propylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 39. To obtain antiparasitic funds took 180 ml of ethanol, 120 ml of isopropyl alcohol, 400 ml of propylene glycol, 35 ml of benzyl alcohol, carefully p who has remesal, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 40. To obtain 1000 ml of antiparasitic funds took 180 ml of ethanol, 120 ml of isopropyl alcohol, 305 ml of propylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and stirred it up. After cooling, the volume was brought to 1000 ml of the primary solvent and re-shuffled.

Example 41. To obtain 1000 ml of antiparasitic remedies prepared a mixture of solvents, which took 350 ml of ethanol, 430 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 100 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 42. To obtain 1000 ml of antiparasitic funds took 350 ml of ethyl is the first alcohol, 430 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 100 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 43. To obtain 1000 ml of antiparasitic funds took 350 ml of ethanol, 410 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 100 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 44. To obtain antiparasitic remedies prepared a mixture of solvents, which took 350 ml of ethanol, 315 ml of polyethylene oxide-400, 35 ml of benzyl alcohol were mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 100 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 45. To get about epoprostenol tools prepared a mixture of solvents, what took 200 ml of ethyl alcohol, 380 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 300 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 46. To obtain antiparasitic remedies prepared a mixture of solvents, which took 200 ml of ethyl alcohol, 380 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 300 ml of water and again mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 47. To obtain 1000 ml of antiparasitic remedies prepared a mixture of solvents, which took 200 ml of ethanol, 360 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 300 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml basis is essential solvent and mixed.

Example 48. To obtain 1000 ml of antiparasitic funds took 200 ml of ethanol, 265 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 300 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Example 49. To obtain antiparasitic remedies prepared a mixture of solvents, which took 300 ml of ethyl alcohol, 305 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 50-51. Prepared 2 composition as in the previous example, but containing 200 ml of ethyl alcohol and 405 ml of polyethylene oxide-400 in one case and 350 ml of ethyl alcohol and 255 ml of polyethylene oxide-400 in the other.

Example 52. To obtain 1000 ml of antiparasitic remedies prepared a mixture of solvents, which took 300 ml of ethanol, 400 ml of polyethylene oxide-400, 35 ml of benzyl sleep is one thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made 15 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. Cooled, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 53-54. Prepared 2 composition as in example 52, but containing 200 ml of ethyl alcohol and 500 ml of polyethylene oxide-400 in one case and 350 ml of ethanol and 350 ml of polyethylene oxide-400 in the other.

Example 55. To obtain antiparasitic tools thoroughly mixed with 300 ml of ethyl alcohol, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol was added to 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 56-57. Prepared 2 composition as in example 55, but containing 200 ml of ethyl alcohol and 520 ml of polyethylene oxide-400 in one case and 350 ml of ethyl alcohol and 370 ml of polyethylene oxide-400 in the other.

Example 58. Prepared 300 ml of ethyl alcohol, 420 ml of triethylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at the same time is the temperature value of 35-40° C to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. Cooled, brought the volume up to 1000 ml of the primary solvent and mixed.

Examples 59-60. Prepared 2 composition as in example 58, but containing 200 ml of ethyl alcohol and 520 ml of triethylene glycol in one case and 350 ml of ethyl alcohol and 370 ml of triethylene glycol in the other.

Example 61. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol 96%, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 62-63. Prepared 2 composition as in example 61, but with the content of novocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 64. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol 96%, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again carefully what Ino mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 65-66. Prepared 2 composition as in example 64, but with the content of novocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 67. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol 96%, 400 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 68-69. Prepared 2 composition as in example 67, but with the content of novocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 70. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol 96%, 305 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then made a 10 g procaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 71-72. Prepared 2 composition as in example 70, but with the content of novocaine 0.5 g/100 m and 3.0 g/100 ml, respectively.

Example 73. To obtain antiparasitic funds took 300 ml of ethyl alcohol 96%, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of benzocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 74-75. Prepared 2 composition as in example 73, but with the content of anaesthetic 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 76. Prepared a mixture of solvents, which took 300 ml of ethyl alcohol 96%, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed. Added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of benzocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 77-78. Prepared 2 composition as in example 76, but with the content of anaesthetic 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 79. To obtain 1000 ml of antiparasitic funds took 300 ml of ethyl alcohol 96%, 400 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, added 200 is closantel sodium and kept in a water bath at a temperature of 35-40° C to dissolve closantel. Then introduced 10 g of benzocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 80-81. Prepared 2 composition as in example 79, but containing benzocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 82. To obtain antiparasitic tools thoroughly mixed with 300 ml of ethyl alcohol 96%, 305 ml of polyethylene oxide-400, 35 ml of benzyl alcohol was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of benzocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 83-84. Prepared 2 composition as in example 82, but containing benzocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 85. To obtain antiparasitic funds took 300 ml of ethyl alcohol 96%, 420 ml of propylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, added 50 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of lidocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent is mixed.

Examples 86-87. Prepared 2 composition as in example 85, but with the contents of lidocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 88. To obtain antiparasitic funds took 300 ml of ethyl alcohol 96%, 420 ml of polyethylene oxide-400, 35 ml of benzyl alcohol, thoroughly mixed, was added 100 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of lidocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 89-90. Prepared 2 composition as in example 88, but with the contents of lidocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 91. To obtain antiparasitic funds took 300 ml of ethyl alcohol 96%, 300 ml of polyethylene oxide-400, 100 ml of triethylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, added 200 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of lidocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 92-93. Prepared 2 composition as in example 91, but with the contents of lidocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

Example 94. To obtain 1000 ml about epoprostenol funds took 300 ml of ethyl alcohol 96%, 305 ml of triethylene glycol, 35 ml of benzyl alcohol, thoroughly mixed, was added 400 g of closantel sodium and kept in a water bath at a temperature of 35-40°to dissolve closantel. Then introduced 10 g of lidocaine, 10 g polyvinylpyrrolidone, 160 ml of water and again thoroughly mixed. After cooling, the volume was brought to 1000 ml of the primary solvent and mixed.

Examples 95-96. Prepared 2 composition as in example 94, but with the contents of lidocaine 0.5 g/100 ml and 3.0 g/100 ml, respectively.

The proposed remedy is effective in the treatment of nematodosis, hypodermics and other parasitic diseases. Percutaneously antiparasitic products containing higher concentrations of closantel and minimum of the indicated concentrations of anaesthetic substances (i.e. funds received by examples 10, 40, 71, 83, 95), 35% of cows observed the formation of minor swelling at the injection site, held in 2-4 days. In intramuscular any local reactions in cows not observed. Milk production even in the first days after the drug is practically not reduced.

The preparations containing the active substance 40% have a higher viscosity. Therefore, it is preferable to use for the treatment of animals solutions antiparasitic preparations with concentrations closantel not more than 25%.

<> The technical result of the proposed tools is higher efficiency antiparasitic action in the absence of pain and inflammatory response in animals as intramuscular and subcutaneous medications. In addition, cows not observed reduction in milk yield.

1. Antiparasitic agent for the prophylaxis and treatment of animals containing closantel or its sodium salt, dissolved in a primary solvent, which is used as the polyethylene glycol, propylene glycol, triethylene glycol or mixtures thereof, as well as an anaesthetic substance, ethyl and/or isopropyl alcohol, benzyl alcohol, polyvinylpyrrolidone and water in the following ratio of components, g/100 ml:

Closantel or its sodium salt5-40
An anaesthetic substance0,5-3,0
The ethyl and/or isopropyl20-28
Benzyl alcohol : 3,1-5,2
Polyvinylpyrrolidone0,5-1,0
Water10-20
The main solventRest

2. Antiparasitic agent according to claim 1, characterized in that as usual prophetic is tion contains procaine, lidocaine or benzocaine.



 

Same patents:

FIELD: veterinary science.

SUBSTANCE: the suggested preparation contains Trichlorfon and 30%-ethanol at the following ratio of components, weight%: Trichlorfon 3.5-3.7 and 30%-ethanol or 3%-boric acid solution in 30%-ethanol - up to 100. Application of this innovation enables to shorten therapy terms and improves therapeutic effect.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: veterinary medicine.

SUBSTANCE: composition comprises solution for per os introducible to animals. The solution contains Phenasal and additives. Phenasal is applied as solution of its salt in aprotonic bipolar hydroxyl-containing solvents and bases.

EFFECT: high therapeutic activity; reduced Phenasal consumption; enhanced effectiveness of treatment.

4 cl, 2 tbl

FIELD: veterinary, in particular helminthology.

SUBSTANCE: claimed agent contains pyrantel, sodium ribonucleate, distilled water and target additive in ratio (mass pts) of 0.5-2.0:0.5:24:34.5, respectively. As target additive emulsifier and stabilizer are used. Pharmaceutical agent of present invention makes it possible to increase therapeutic effectiveness of pyrantel, to prevent eelworm reinvermination of animals, and to improve animal immune status.

EFFECT: drug against animal eelworm of improved effectiveness.

2 cl, 5 ex, 3 tbl

FIELD: veterinary, in particular helminthology.

SUBSTANCE: claimed agent contains pyrantel, sodium ribonucleate, distilled water and target additive in ratio (mass pts) of 0.5-2.0:0.5:24:34.5, respectively. As target additive emulsifier and stabilizer are used. Pharmaceutical agent of present invention makes it possible to increase therapeutic effectiveness of pyrantel, to prevent eelworm reinvermination of animals, and to improve animal immune status.

EFFECT: drug against animal eelworm of improved effectiveness.

2 cl, 5 ex, 3 tbl

FIELD: veterinary medicine.

SUBSTANCE: method involves administering Aversect-2 with Cordeon probiotic added at a dose of 50 mg/kg of live weight during 5 days.

EFFECT: enhanced effectiveness of treatment; improved blood biochemical and hematological properties.

3 tbl

FIELD: veterinary medicine.

SUBSTANCE: method involves administering Aversect-2 with Cordeon probiotic added at a dose of 50 mg/kg of live weight during 5 days.

EFFECT: enhanced effectiveness of treatment; improved blood biochemical and hematological properties.

3 tbl

FIELD: medicine.

SUBSTANCE: method involves administering antihistamine preparations and antibiotics, applying external treatment of injured skin areas with Hypchlophos, intramuscularly introducing anatoxin vaccine against animal staphylococcosis and immunostimulating agent like Immunoparasitan. Reinfusion session is applied at the treatment beginning after ultrasonic proper blood irradiation having been applied at a dose of 1-3 cm3/kg of body mass. Vitamin B12 is additionally intramuscularly introduced at a dose of 3-7 mcg/kg of body mass at the treatment course end. Hypchlophos is applied as oil emulsion in 1:1 proportion. Reinfusion combined with ultrasonic proper blood irradiation is administered together with anatoxin vaccine introduction at the same day continuing the treatment within 2-3 days.

EFFECT: enhanced effectiveness in normalizing metabolism processes and in increasing immunostimulation; reduced toxic adverse side effects.

4 cl, 1 tbl

FIELD: pharmaceutical industry and technology.

SUBSTANCE: invention relates to a method for preparing agent possessing with antilambliosis and anti-opisthorchiasis effect. Method is carried out by continuous extraction by re-percolation of willow-leaves saw-wort (Saussurea salicifolia L. DC., family Asteraceae) milled flower-bearing stem tips (length is below 30 cm) with 70% ethyl alcohol in battery consisting of five percolators under the definite conditions. Method provides effective increase of the yield of active substances and pharmacological activity of the prepared agent.

EFFECT: improved preparing method.

6 tbl, 13 ex

FIELD: organic chemistry, medicine, parasitology, pharmacy.

SUBSTANCE: invention relates to spiro- or dispiro-1,2,4-trioxolane of the general formula (I): wherein R1 and R2 taken in common represent spiroadamantyl, 3,3,5,5-tetramethylspirocyclohexyl, spirocyclododecanyl; R3 and R4 are similar or different and taken among substituted or unsubstituted aromatic or pyridyl group wherein neither among R3 and R4 can't represent hydrogen atom; also, R3 and R4 taken in common can form substituted or unsubstituted alicyclic group that is broken optionally with one oxygen, sulfur or nitrogen atom. Proposed compounds can be easily used for synthesis of nontoxic and active agents used against anti-malaria parasites. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and a method for treatment of malaria and schistosomiasis.

EFFECT: improved method for treatment, valuable medicinal properties of compounds and composition.

19 cl, 10 tbl, 9 ex

FIELD: medicine, in particular medicine parasitology, helminthism treatment.

SUBSTANCE: claimed method includes simultaneous action of lemon juice and decoction of eucalyptus according to specific schedule. Lemon juice is administered perorally and rectally, and decoction of eucalyptus is administered rectally by enema. Course of treatment includes 8-10 days.

EFFECT: method for intensive ousting both nemathelminthes and cestodes without toxic action.

3 ex

FIELD: medicine.

SUBSTANCE: method involves administering required dose of renin-angiotensin inhibitor Ramipryl or its salt combined with a hypotensive drug, means for reducing cholesterol content, diuretic or aspirin to patients showing no signs of left ventricle dysfunction or cardiac insufficiency.

EFFECT: prevented cardiovascular attacks, angina pectoris, diabetes manifestations.

18 cl, 5 tbl

FIELD: medicine.

SUBSTANCE: method involves applying composition based on receptor antagonist P substance and magnesium salt.

EFFECT: reduced hematoencephalic barrier permeability; reduced risk of vasogenic brain edema; prevented water accumulation in brain; smoothing consequences caused by reduced cognitive abilities.

23 cl, 2 dwg, 3 tbl

FIELD: pharmacy.

SUBSTANCE: invention proposes pharmaceutical compositions consisting of multiple particles with sustained-release of serotonin reuptake selective inhibitor (SRSI) with membrane cover comprising ammonium-methacrylate copolymer, or compositions comprising SRSI particles mixture, or compositions comprising SRSI particles mixture in form of sustained-release of SRSI, Also, invention relates to method for treatment of depression involving administration of these compositions. In particular, SRSI represents fluoxetine, fluvoxamine, sertraline or their salt. Proposed compositions provide a less index of fluctuations that reflects lower values of maximal concentrations of substance in plasma blood after multiple administrations, safety and good tolerance also.

EFFECT: improved medicinal and pharmaceutical properties of compositions.

11 cl, 5 dwg, 26 tbl, 6 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a pharmaceutical preparation based on angiotensin-converting enzyme inhibitor, its using in prophylaxis of insult, diabetes and/or congestive cardiac insufficiency and corresponding methods for its using in patient with maintenance heart function and subjected for risk of cardiovascular attack due to previous history of ischemic disease, insult or peripheral arterial disease. In particular, inhibitor of angiotensin-converting enzyme can be chosen from ramipril, ramiprilat, lisinopril, enalapril and enalaprilat. Invention promotes to reducing the total lethality of patients group in case of cardiovascular diseases, cardiac attacks and insults, the necessity for carrying out procedures for revascularization (such as surgery operation for coronary shunt, angioplasty with using balloon and so on) and diabetic complication are diminished.

EFFECT: improved and valuable medicinal properties of preparations.

19 cl, 1 ex

FIELD: medicine.

SUBSTANCE: method involves introducing solutions into articulation to inhibit cartilage destruction. The solutions contain: (a) therapeutically effective amount of anabolic chondroprotective agent selected from a group composed of interleukine antagonists stimulating anabolic processes in cartilage, members of superfamily transforming growth β-factor including TGF-β agonists and agonists of morphogenous bone proteins stimulating anabolic processes in cartilage, insulin-like fibroblast growth factors stimulating anabolic processes in cartilage; (b) therapeutically effective amount of a cartilage catabolism inhibitor selected from a group composed of antagonists of interleukine-1-receptors, antagonists of TGF-α-receptors, specific cyclo-oxygenase-2 inhibitors, nitrogen oxide synthase inhibitors, nuclear kB factor inhibitors, matrix metalloproteinase inhibitors, cell adhesion molecules including integrin agonists and integrin antagonists, anti-chemotaxis agents, intracellular signal transmission inhibitors including protein kinase C inhibitors and tyrosine protein kinase inhibitors, intracellular (protein-tyrosine)-phosphatases and SH2-domain inhibitors inhibiting cartilage catabolism. The solution is locally supplied.

EFFECT: stimulated integration and modulation of anti-inflammatory synoviocyte and chondrocyte responses.

54 cl, 9 dwg, 30 tbl

FIELD: medicine.

SUBSTANCE: invention proposes a method for inhibition of chorionic neovascularization. Method involves irradiation of undesirable novel vascular reticulum in combination with photosensitive agent (porphyrine) and an anti-angiogenic agent taken among antagonist of phospholipase A2, inhibitor of complex kappa B, inhibitor of the growth hormone, inhibitor of insulin-like growth factor-1, inhibitor of cyclooxygenase II, inhibitor of protein kinase C (stautosporin PKC 412) and inhibitor of angiotensin II. The claimed combined treatment provides potentiation of effect of adjunctive photodynamic therapy in combination with enhanced safety.

EFFECT: improved treatment method.

7 cl

Nutrient module // 2268069

FIELD: medicine.

SUBSTANCE: method involves adding to patient food one or several compositions via closed system in module form containing nutrient substances selected and adapted to given clinical state. The modules are most kept in dry form.

EFFECT: enhanced effectiveness in preparing patient food; avoided contamination with microorganisms; enhanced effectiveness in treating and feeding patients.

20 cl

FIELD: medicine.

SUBSTANCE: method involves administering a combination of an agent reducing cholesterol content in blood and reduced coenzyme Q10 of general formula .

EFFECT: enhanced effectiveness of treatment.

8 cl, 2 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes implant prepared by mixing a carrier material with components of the preparation antibiotic/antibiotics with delayed release of an active substance (aminoglycoside, lincosamide antibiotics, 4-quinolone antibiotics and tetracyclines), and a method for preparing the implant. Release of an active substance from implant during from some days to some weeks doesn't dependent from a carrier material and adsorption effects of a carrier-material surface.

EFFECT: improved and valuable properties of preparation.

13 cl, 1 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with composition for fertilization in vitro and the system for its delivering (device). The composition suggested contains steroid at the quantity of below 5% (weight/weight), that is: 4.4-dimethyl-5α-cholesta-8.14.24-trien-3β-ol, hemisuccinate of 4.4-dimethyl-5α-cholest-8.14.24-trien-3β-ol; 5α-cholest-8.14-dien-3β-ol; hemisuccinate of 5α-cholest-8.14-dien-3β-ol; (20S)-cholest-5-en-3, 20-diol; N-(methionine)amide of 3β-hydroxy-4.4-dimethyl-5α-chol-8.14-dien-24-oic acid or cholest-5-en-16β-ol, and, also, additive (water-soluble protein or phosphoglyceride). Delivering system has got either one foramen or one cavity that contains the composition mentioned as a solid product or solution. The composition of sterols contains no constituents negatively affecting oocytes and could be dissolved in aqueous medium without physical impact (that is, heating, mixing or ultrasound treatment).

EFFECT: higher efficiency of fertilization in vitro.

8 cl, 5 ex, 3 tbl

FIELD: pharmaceutical technology, pharmacy.

SUBSTANCE: method involves addition sugar-alcohol and/or saccharide showing melting point by 5°C lower or above as compared with the first mentioned sugar-alcohol and/or saccharide to sugar-alcohol and/or saccharide followed by combined treatment of prepared powder by pressing and heating. Invention allows preparing medicinal compositions decomposing in mouth cavity rapidly being without water and showing light using owing to the presence of sufficient strength in preparing, transport in usual using. Method involves mixing, pressing and heating components that represent two or more sugar-alcohol and/or saccharide and active component wherein difference between melting points of one among two or more indicated sugar-alcohol and/or saccharide that shows the higher content and any remaining indicated two or more sugar-alcohol and/or saccharide is 5°C or above. Invention provides preparing strength rapidly soluble tablets.

EFFECT: improved preparing method, improved pharmaceutical properties of composition.

30 cl, 12 tbl, 28 ex

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