Method for treating psoriasis

FIELD: medicine, dermatology.

SUBSTANCE: one should perform laserophoresis with IR-laser of gelling form of medicinal preparation based upon pantohematogen in projection of large vessels of the upper and lower limbs by alternating the impact every other day in axillary and cubital areas at irradiating popliteal and inguinal areas. Impulse frequency corresponds to patient's respiration frequency. Impact terms correspond to about 4-5 min at the field to achieve stationary-regressing stage. Then it is necessary to conduct the course of baths with pantohematogen solution at concentration being 0.03-0.08 g/l, at gradually increasing water temperature from 36-37°C up to 39-40°C and shortening the time for the procedure from 15 min up to 8 min for the course of 10-12 procedures every other day. The innovation has pronounced antiphlogistic action, activates total immunity, improves skin microcirculation along with stabilization of proliferative and increases metabolic-trophic processes, normalizes locomotor articular function at accompanying psoriatic polyarthrites.

EFFECT: higher efficiency of therapy.

3 ex

 

The invention relates to medicine, namely to physical therapy and dermatology, and can be used for the treatment of psoriasis.

The development of the psoriatic process due to the instability of nonspecific reactivity of the organism under the influence of a range of pathogenicity reactions that determine the nature of the clinical disease.

Currently, there are various ways of treatment of psoriasis in the complex which are usually included pharmacotherapy, physiotherapy and health resort treatment. However, poorly understood disease pathogenesis, continued frequency and duration of recurrent skin lesions are forced to look for new methods of treatment of this disease.

There is a method of treatment of psoriasis by irradiation of blood helium-neon laser in the area of the cubital vein, which previously applied product containing a mixture of polyene acids (Patent RF №2142830, IPC A 61 N 5/06, publ. 1999).

The disadvantage of this method is the necessity of prolonged laser irradiation up to 30-40 minutes a day long course, will affect only the area of the cubital vein, which has a predominantly General effects, but can not fully normalize tissue the flow and local immunity in the peripheral parts of the limbs, in addition, does not allow for subjective pain the feelings in the form of itching in the distal upper and lower extremities.

Psoriasis is known to the application of salt (sea) bath at a water temperature of 37-38°when the salt concentration 5 g/l, with a duration of 15 minutes Daily rate of 15-20 baths (Ushakov A.A. Modern physiotherapy in clinical practice. - M. ANMI - 2002. - s).

The disadvantages of this technique include the possibility of its application only in stable remission. In addition, given the changes in the skin, can increase skin sensitivity to salts with symptoms of irritation. Should be considered contraindications to the sea-baths: status earlier than 1 year after septic thrombophlebitis, less than 2-3 months after thrombosis, recurrent thrombosis, thrombophlebitis with progressive inflammatory changes, chronic renal insufficiency II-III of the article, ray.

The closest is a method of treating psoriasis, comprising applying to the skin of a medicinal product on the basis of pantogematogen with further exposure to preformed factor electrophoresis on a course of 10-15 treatments (RF Patent No. 2162352, IPC A 61 N 1/30, publ. 2001)Electropores 0.9-1.1% aqueous solution of pantogematogen performed on lesions on 2-4-8 contact method, and when a large extent of the process, alternating with the effect on the reflex-segmental segments, exposure 25-30 minutes, at the rate of 10-15 egene the procedures.

The disadvantages of this method of treatment should include a limited effect on the lesions; itching, burning, irritation of the skin under the electrodes, the positive development of the phenomenon of Cabrera in progressive stage due to the impact of galvanic current; limitation destination due to the presence of comorbidity and individual intolerance of the electric current.

The task of the invention is to remedy these disadvantages, the efficiency of treatment and the prolongation of the remission period in patients with psoriasis in the progressive stage, especially when massive skin lesions. A pronounced anti-inflammatory effect, activation of immunity, improvement of microcirculation of the skin with stabilization proliferative and increased metabolic and trophic processes is provided by the synchronization parameters of laser radiation with a frequency of breathing of the patient. Prolonged effects of drugs on the basis of pantogematogen is achieved by interleaving the way of penetration in the body, which greatly increases the effectiveness of treatment and improves locomotor function of joints with concomitant psoriatic arthritis.

For this purpose, the method of treating psoriasis, comprising applying to the skin of a medicinal product is and the basis of pantogematogen with further exposure to preformed factor, the proposed gel form of the drug is applied on the four projections of large vessels of the upper and lower limbs, alternating every other day, then produce as preformed factor exposure to IR laser with a pulse frequency corresponding to the frequency of respiration of the patient, for 4-5 minutes on the pitch before reaching the stationary regressing stage, followed by a course of baths with a solution of the drug on the basis of pantogematogen at a concentration of 0.03-0.08 g/l, gradually increasing the water temperature from 36-37° up to 39-40°and reducing the procedure time from 15 minutes to 8 minutes the course of 10-12 treatments a day.

The method is as follows.

At the first stage of treatment of psoriasis with different prevalence of skin lesions produce transcutaneous introduction of helium forms of drugs (Pantonic-1, Pantonic-2) on the basis of pantogematogen method laserforce in the projection of the major neurovascular formations, alternating every other day impact in the area of the armpit and cubital areas, the next day, with exposure of the popliteal and inguinal areas, 4 field day at output power of 10 mW at the fiber output, respiratory rate of the patient (individually from 8 to 23 per minute)for 5 minutes on the field with a total exposure time of 20 min per day. Course 10-12 daily procedures. In the second stage, after a hundred the waste utilization technologies skin recovery process is a course of baths with a solution of Antonica-1 or Antonica-2 at a concentration of 0.01-0.03 g/l when gradually increasing the water temperature from 36-37° to 39-40°and decreasing the time from 15 minutes to 8 minutes during the course of 10-12 treatments a day.

This technique has a pathogenic effect, which is manifested by normalization ostrofsky whey proteins (haptoglobin and alpha-1 proteinase inhibitor), which are markers of the inflammatory process and the level by which to judge the degree of disease activity. Evaluation of the effectiveness of the method was confirmed by the improvement of the functional state of the organism after treatment with complex TDK-Chronos". The state process of the skin was evaluated by the change in PASI index.

According to this method, treated 50 patients with a positive effect. The reduction in bed-days and lengthening the time of remission brought economic effect.

Example 1.

Patient M., age 16 (East. bol. No. 14917, 2004), was admitted with a diagnosis of Common vulgar psoriasis, progressive stage. Ill for 6 years. Previously treated with conventional methods. At admission the patient to the hospital, his skin was presented multiple psoriatic plaques on the skin of the trunk and extremities. Lesions covered with silvery-white scales on the periphery there is a ring of hyperemia. From subjective sensations experienced moderate itching.

Physiotherapy treatment, including at the first stage in the progressive stage of transcutane introduction helium forms of drug Pantonic-1 method laserforce in the projection of the major neurovascular structures in the field of axillary and cubital areas alternating every other day with irradiation popliteal and inguinal areas, 4 field day with capacity of 10 mW at the fiber output, respiratory rate of the patient (12 min), 5 minutes on the field with a total exposure time of 20 min per day. Course - 10 daily procedures.

Psoriatic elements to the fifth session paled considerably decreased necrosis and infiltration disappeared whisk hyperemia on the periphery of the elements. After 10 session the skin moved in a Contracting phase, as evidenced by the appearance of pseudotropicalis rim Voronova and the beginning of recourse in the Central part of plaques. In the second stage has received a course of baths with a solution of Antonica-1 concentration of 0.01 to 0.03 g/l at gradually increasing the water temperature from 36-37° up to 39-40°and decreasing the time from 15 minutes to 8 minutes in the course of 10 treatments a day.

After the second stage psoriatic elements was resolved completely. Examination of the patient six months later showed that the skin is in remission.

Example 2.

Patient T., born in 1982 (the East. bol. No. 15220, 2004), was admitted to the Department of dermatology and Oncology and dermatology with a diagnosis of Psoriasis vulgaris, is a common, progressive stage. Ill for 10 years. Throughout time the clinical picture of the disease was predstavleniyami lesions localized on the scalp, the extensor surface of the upper and lower extremities, peaking in autumn-winter. The treatment was carried out on an outpatient basis, using traditional methods. This aggravation, within two weeks, caused transferred stress. The skin presents common lesions of different size elements (from 0.3 to 15 cm in diameter) with localization on the scalp, the skin of the trunk, extremities. Papules and plaques rich red color, with a pronounced peeling in the Central part, around the items marked bezel Elnova, the phenomenon of Auspitz positive.

The patient received comprehensive treatment, including the photophoresis of Pantonic-1 according to the above method, the emission frequency of 18 Hz, 5 min on the field with a total exposure time of 20 min per day. Course - 12 daily procedures. After conducting 6 procedures rash faded, disappeared bezel Pytlikova, began to emerge pseudotropicalis bezel - start fixed-Contracting stage. After 12 treatments the patient was discharged to outpatient treatment with the application of the second stage of treatment with the use of this drug in the form of baths. During examination of the patient four months in skin process marked remission.

Example 3.

Patient T., born in 1952 (East. bol. No. 15473, 2004), was admitted with a diagnosis of Psoriatics what I erythroderma. Considers himself ill for about 30 years. Previously had repeatedly been undergoing treatment with methotrexate and diprospan in the treatment of disease. therapy has been positive, but short-term effect. In recent years the disease has become torpid course. At admission the patient to the hospital, his skin was bright red, swollen, infiltrated, with abundant coarse lamellar desquamation. The patient complained of severe itching, malaise, weakness and fever in the evening until 37,7. The patient was carried out by the proposed method in combination with traditional therapy. The impact produced with a frequency of 16 Hz. Course - 12 daily procedures. The patient, after 12 sessions of laserforce of Antonica-2 significantly decreased the redness, swelling and peeling, improved General condition, normalized body temperature, appeared plots "healthy skin". The patient was discharged from hospital in satisfactory condition for the second step of the described method in the home in the amount of 12 sessions baths.

The patient was examined in four months. The skin presents "duty plaques" in the lower back, knees and elbows. Exacerbation of the disease there.

The proposed method of treatment is simple the th in execution, available for not only in hospital but also in the outpatient setting. The possibility of continuing treatment baths yourself at home helps to restore the health of the patient, the normalization of its psycho-somatic status and accelerate its social adaptation. The economic effect is to shorten the stay of the patient on sick leave, availability of domestic products on the basis of pantogematogen, the use of domestic laser equipment.

A method of treating psoriasis, comprising applying to the skin of a medicinal product on the basis of pantogematogen with further exposure to preformed factor, characterized in that exercise literatures IR-laser gel form of the drug on the basis of pantogematogen in the projection of large vessels of the upper and lower limbs, alternating every other day impact in the area of the armpit and cubital areas with exposure of the popliteal and inguinal areas, with a pulse frequency corresponding to the frequency of respiration of the patient, for 4-5 minutes on the pitch before reaching the stationary regressing stage, followed by a course of baths with a solution of pantogematogen at a concentration of 0.03-0.08 g/l, at gradually increasing the water temperature from 36-37° up to 39-40°and reduce the time by the URS from 15 min to 8 min on a course of 10-12 treatments a day.



 

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2 ex

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13 cl, 1 tbl

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