Method for administering medical care to patients at pre-admission stage in acute poisoning with acetic acid

FIELD: medicine.

SUBSTANCE: method involves taking into consideration dose-exposure plot, age, hourly diuresis, hemolysis, exotoxic shock, larynx edema, hemoglobinuria availability, measuring body temperature and evaluating each symptom in points. The points are summed. Their sum being less than -17, favorable prognosis is formulated and line emergency team gives medical care. The sum of points being from -17 to +23, outcome prognosis is doubtful. The sum being greater than +23, the prognosis becomes unfavorable. The last two cases Poison dose is additionally determined irrespectively of exposure, vomiting and its nature, gastroesophageal hemorrhage, hemolysis, oliguria, larynx edema exotoxic shock, hemolysis, hemoglobinuria availability, measuring body temperature and evaluating each symptom in points. The points are summed. Their sum being less than -20, line emergency team gives medical care. The sum of points being greater than +20, resuscitation aid and calling for resuscitation group of emergency team on himself with state stabilization and transporting patient with the resuscitation group to the nearest resuscitation department following. Premedication, analgesics, spasmolytics, corticosteroids and hemostatics are administered with probe-mediated gastric lavage and infusion therapy being started.

EFFECT: enhanced effectiveness of treatment; high objectivity in evaluating patient health state.

1 dwg, 6 tbl

 

The invention relates to medicine, namely to clinical toxicology, allows you to assess the condition of the patient with acute oral poisoning with acetic acid, to give a prediction of outcome with elements of the medical sort, and accordingly to apply differential algorithm of actions prehospital stabilization of state and transportation of the sick.

Known way to assess the severity of patients with acute poisoning by chemicals cauterizing action proposed (Persson et al., 1998), but this method requires additional biochemical and instrumental methods, which is possible only on inpatient care.

There is a method to objectively determine the need for intensive care in poisoning with acetic acid, the proposed SchemaName and Iaiaanaeo in 2002 [shamanaev AGRICULTURAL, Jamanaeva I.E. the Application of probabilistic recognition methods in clinical toxicology // Toxicol. Herald. - 2002. No. 4. - C.17-29], but this method is intended for poisoning acetic acid for use only at the hospital stage.

The method of assessment and prediction of outcome in acute poisoning with acetic acid and the corresponding elements of the medical sort and sequence of actions prehospital not described in literature.

adaca of the invention was to develop objective criteria for the assessment of, unified medical sorting during the initial contact between doctor and patient and an action plan for the stabilization and target transportation in hospitals patients with acute poisoning with acetic acid.

The technical result when using the invention, the objectivity of the assessment of patients with acute poisoning acetic acid, prediction of outcome and differentiated sequence of medical care.

Us using heterogeneous sequential detection Gen and Ewhole [Gubler E.V. Computational methods of analysis and recognition of pathological processes. - L.: Medicine, 1978. - 296 p] was the selection of informative features with their ranking using informative measure Kullback. For the selected traits were calculated diagnostic odds - points.

When using the method the points are summed to achieve the threshold: positive (excess of his means of adverse outcome), negative (if exceeded, it means a favorable outcome) and intermediate (doubtful outcome).

Was investigated the diagnostic significance of the following parameters: age, gender, the intention of poisoning, alcohol intoxication, "dose-exposure, the time of receipt. According to clinical OSM is tra were included such features as: the nature vomiting, its multiplicity and the blood, depression of consciousness, body temperature, respiratory rate per minute, dysphonia, the level of mean arterial pressure, heart rate, coefficient of Allgower, hemoglobinuria, oliguria (hourly diuresis). Take into account the development of such complications as: Ecotoxicity shock, gastrointestinal bleeding, pneumonia, pulmonary edema, DIC. From these characteristics the most informative was 8 (table 1) and 9 signs (table 2).

The illustration depicts the algorithm of the method.

The method is as follows.

When patient assessment and history taking to determine the dose-exposure, age, hourly diuresis, the presence of hemolysis, ekzoticheskogo shock, laryngeal edema, hemoglobinuria, measure the body temperature.

Each symptom scored in accordance with table 1, namely: the presence of hemolysis was evaluated as "+3" points, its absence as "-9" points; hourly urine output less than 30 ml/h was evaluated as "+6" points, more than 30 ml/hour as "-5" points; the development ekzoticheskogo shock was evaluated as "+10" points, its absence as "-2" point; the dose-exposure less than 3 hours, and the volume to 50 ml estimate as "-4" grade "dose-exposure less than 3 hours, and the volume from 50 to 100 ml as "+2" points, "dose-exposure less than 3 hours, and the volume of >100 ml as "+6" points, "dose-expos the Oia" more than 3 hours and the volume to 50 ml as "-8" points, "dose-exposure for more than 3 hours, and the volume from 50 to 100 ml as "-2" points, "dose-exposure for more than 3 hours, and the volume of >100 ml as a+9 points; age (years) 40 assessed as "-9" points, from 40 to 70 as "+2" points, >70 years as "+5" points; body temperature normal evaluated as "+3" points, 37°as "+3" score, >37°as "-6" points; the presence of hemoglobinuria evaluated as "+4" points, its absence as "-4" points; the presence of laryngeal edema was evaluated as "+4" points, its absence as "-2" points. The received data is summed and if the score was less "-17", the prognosis is favorable, in this case a linear brigade conduct lavage of the stomach, pain management, introduction of antispasmodics and corticosteroids, transport the patient to the hospital. If the sum of the scores from "-17" to "+23", the prognosis of the outcome remains in doubt, with the possibility of death; if the score was more "+23", the patient is regarded as a potentially adverse; in the latter two cases for determining the needs of the patient in the intensive care manual additionally determine the dose of poison, regardless of exposure, vomiting and her character, the presence of esophageal-gastric bleeding, hemolysis, oliguria, edema of the larynx, ekzoticheskogo shock, hemoglobinuria, measure the temperature of the body, each characteristic evaluated the ball is Oh, namely esophageal-gastric bleeding was evaluated as "+13" points, no "-2" points; no vomiting was evaluated as "-3" points", single vomiting as "-3" points, repeated vomiting as "+8" points, once with blood as "+5" points, multiple blood as "+12"; the absence of hemolysis was evaluated as "-7", the presence of both the "+4" score; dose of poison (regardless of exposure) to 30 ml estimate as "-6" points, the dose from 30 to 50 ml as 0 points, dose from 50 to 100 ml as "+5" points, dose >100 ml as "+10" points; the presence of hemoglobinuria evaluated as "+7" points, no "-2" points; ekzoticheskogo shock was evaluated as "+12" points, no ekzoticheskogo shock assessed as "-1" point, the body temperature of the patient to 37°With regards as "+2" points, temperature 37°With degrees as "-4" points, the body temperature of the patient more 37,0°evaluate as ' -6" points; the presence of oliguria (hourly urine output less than 30 ml/hour) estimated as "+6 points, no "-2" points; the presence of laryngeal edema was evaluated as "+4" points, no "-2" points (table 2). The data obtained are added up. If a score of less than "-20", the resuscitation of benefits is not required and assistance linear ambulance (SMP), which provides sedation and lavage of the stomach, after which the patient will be hospitalized in hospitals. When the amount of points more than the"+20" the patient requires the provision of emergency assistance and call your doctor linear brigade specialized resuscitation team SMP "on", with subsequent stabilization of state and transportation of the patient's resuscitation team in the nearest intensive care unit. Before the arrival of the resuscitation team line team are sedation, administration of analgesics, antispasmodics, corticoids and hemostatics, probe lavage, begin infusion therapy (see figure 1).

The proposed method is illustrated by the following examples.

Example 1. Patient M., 36 years, against the background of alcohol drank 2 SIPS of a 70%aqueous solution of acetic acid. Sought medical help after 13 hours.

Complaints about pain when swallowing, but violations of the passage of liquid and solid food is not noted, concerned about pain in the epigastric region, nausea.

On examination: skin, damaged, dry. The vesicular breathing, single dry rales. The frequency of respiratory motion - 20 per minute. Hemodynamics satisfactory rate of 84 per minute, blood pressure of 140/90 mm Hg Zev hyperemia, somewhat swollen, in the language areas of desquamation of the epithelium. Dysphagia Art. I (Bown). The abdomen is soft, painful in the epigastric region, signs of peritoneal irritation no. Diuresis, 600 ml, the urine color colors strong brewed tea. Body temperature - 37,4°C.

The scoring of the patient's condition according to table 1 was "-34" score that certificate is listwhat about the high probability of a favorable outcome (table 3). Since in this case the assessment of the patient with the help of table 2 is not required, provided symptomatic treatment (according to the proposed algorithm for a favorable outcome): prednisone 60 mg intramuscularly, analgin 50%-2,0 ml; diphenhydramine 1%-1,0 ml; papaverine 2%-2,0 ml intramuscularly. The stomach is not washed out because of the categorical refusal of the patient from washing.

Diagnosis: Acute oral poisoning (70%) solution of acetic acid. A mild degree. Suicide.

The patient refused hospitalization. Recommended: acceptance of the enveloping means drinking plenty of fluids, control of diuresis, the supervision of a gastroenterologist.

Example 2. Patient B., aged 77, on the background of the alcohol withdrawal syndrome, accidentally drank 50 ml of solution (70%) acetic acid. Asked for help after 12 hours, when she could not swallow the liquid. Was repeatedly vomiting blood. Independently tried to wash my stomach "restaurant by the way."

Complaints of pain when swallowing liquid and failure to take solid food, repeated vomiting with blood, mild epigastric pain, and headaches. Notes dark urine after 3 hours until brown.

In the initial examination is a serious condition. The patient in mind, some excited, position compulsive - lying. The skin is damaged, wet, disorder perifericescimi. Breathing is noisy, takes place in all departments, a single moist rales over the entire surface of the lungs. Respiratory rate is 24 in 1 minute. Heart sounds muffled, rhythmic, heart rate 92 in 1 minute, BP 180/110 mm Hg(normal, according to patient's HELL 150/90 mm Hg) Pulse voltage. Zev hyperemia, swollen. Tongue dry, covered with white, easy strippable coating. The stomach is involved in the act of breathing is limited, soft, pain in the epigastric region, signs of peritoneal irritation no. Dysphagia III (Bown). Symptom of Pasternack positive on both sides. Diuresis reduced to 200 ml, urine "brown" color. Chair no. The body temperature of 37.5°C.

The scoring of the patient's condition was table 1 "+15 points, so the prediction of outcome regarded as doubtful (table 4). According to the algorithm in table 2 (with questionable prognosis) defined +41 points (table 5), was called "on" resuscitation team. Prior to her arrival, provided the first medical aid according to the proposed algorithm: analgin 50%-2,0 ml with Dimedrol 1%-1,0 ml and spoil 2.0 ml/inkjet, glucose 40% to 20 ml ascorbic acid, 10% -2,0 ml/inkjet, magnesium sulfate 25% to 5.0 ml intramuscularly.

Came after 18 minutes of resuscitation team conducted according to the algorithm for resuscitation team: additional anesthesia with premedication, probe PR is Melanie stomach, filled with 100 ml of 5% solution of aminocaproic acid in the wash water, the blood in small quantities), for the prevention of esophageal-gastric bleeding and hemostasis. To prepare for transportation and reduction processes of hemolysis and prevention of ARF conducted infusion therapy 4% sodium bicarbonate solution (200 ml) and 400 ml of 10% glucose solution with 200 ml of 0.25% solution of novocaine, with the addition of 4.0 ml of furosemide intravenous bolus and 90 mg of intramuscular glucocorticosteroids. Hemodynamics stabilized. The patient has allocated 100 ml of urine red color. The patient was hospitalized in the toxicology Department in 2 hours 25 minutes after ingestion of corrosive poison.

Diagnosis: Acute poisoning (70%) solution of acetic acid. Severe degree.

Complication: Chemical burns of the digestive tract. Esophageal-gastric bleeding. Dysphagia III. Toxic nephropathy. ARF in the stage of oliguria.

Example 3. Patient E., 30, temporarily unemployed, against the background of alcohol, accidentally drank 200 ml of 70% solution of acetic acid. Care (NSR) filed after 11 hours.

After fluid intake, the patient felt a sharp pain and burning in the course of the pharynx, esophagus and stomach, aggravated by the act of swallowing, nausea, repeated vomiting with profuse blood, weakness. Medical benefits provided reanim the operating crew "emergency" without prior call linear brigade.

Objectively: a serious Condition. Contact available hard - locked, periodic excitation. The position forced - sitting. Clothing soiled with vomit mixed with blood. His mouth a sharp smell of acetic acid. Complaints about painful repeated vomiting with blood, dysartria, pain when swallowing, inability to swallow solid food, chest pain, pain in the stomach, reducing the amount of urine, dark-brown. Disorder of the peripheral microcirculation - pale skin with "marble" pattern, wet, determined by the symptom of "white spots". In the mouth on the background of the surviving "boiled" mucous large areas of fresh desquamation of the epithelium of the mucosa with a transition to erosion. Dysphagia II (Bown). The pronunciation of the voiced consonants are not violated. In the lungs, the breathing is weak, is carried out in all departments, are determined moist rales. Respiratory rate to 28 in 1 min, BP 100/60 mmHg, Pulse 90 beats/min, moderate filling and voltage. The stomach is involved in the act of breathing, if painful palpation in the epigastrium. Symptom Shchetkina-Blomberg - negative. Symptom of Pasternack (+) - slabopolozhitelnym on both sides. Diuresis (with words), reduced to 200 ml/day. The chair is decorated, and the regular color. In vomitus admixture of red blood t° body up to 36.7°C.

When assessing SOS the sustainability of table 1 obtained "+30 points - poor prognosis of outcome (table 6). The scoring of the patient table 2 was "+70" (table 7). Given the gravity of the condition of the patient, signs ekzoticheskogo shock, the esophageal-gastric bleeding and ARF adverse forecast for stabilization before transport to a facility that was catheterized 2 cubital vein conducted premedication and sedately, followed by gastric lavage (washing water a small amount of red blood was pouring 100 ml of 5% solution of aminocaproic acid, adjusted infusion of 4% solution of sodium bicarbonate parallel with the introduction of another vein solution reopoligliukina and dexamethasone; patients with stable hemodynamics was hospitalized in the intensive care unit after 45 minutes of treatment in NSR.

Diagnosis: Acute oral poisoning 70% solution of acetic acid. Severe. Random.

Complication: Ecotoxicity shock I. Dysphagia II senior Esophageal-gastric bleeding. Blackwater argued. Toxic nephropathy. ARF in the stage of oliguria.

Concomitant disease: Alcohol intoxication.

Table 1

Assessment of the patient with acute poisoning acetic acid (for linear ambulance teams)
No.Symptom present in the patientScore
1HemolysisYes3
no-9
2Hourly diuresisless than 30 ml/h6
more than 30 ml/h-5
3Ecotoxicity shock+10
no-2
4The dose-exposure time"Exposure time less than 3 hours, when the amount of poison
to 50 ml-4
50-100 ml+2
>100 ml+6
Exposure time for more than 3 hours, when the amount of poison
to 50 ml-8
50-100 ml-2
>100+9
5Age, years 40-9
70+2
>70+5
6Temperature, °up to 37°+3
37°+3
>37°-6
7The hemoglobinuria+4
no-4
8Laryngeal edema+4
no-2
AMOUNT""

2
Table 2

Determination of need for intensive care manual patient with acute poisoning acetic acid (for linear ambulance teams)
No.Sign existing patientScore
1Esophageal-gastric bleeding+13
no-2
Vomitingno-3
single-3
multiple+8
a single blood+5
multiple blood+12
3Hemolysis+4
no-7
4Dose of poison (regardless of exposure)to 30 ml-6
30-50 ml0
50-100 ml+5
>100 ml+10
5The hemoglobinuria+7
no-2
6Ecotoxicity shock+12
no-1
7The body temperature of the patient °up to 37°+2
37°-4
>37°-6
8Oliguriathere,+6
no-2
9Laryngeal edema+4
no-2
AMOUNT" "

Age, years
Table 3

Assessment of the patient M with acute poisoning acetic acid
No.Symptom present in the patientScore
1Hemolysisno-9
2Oliguriano-5
3Ecotoxicity shockno-2
4The dose-exposure time"Exposure time for more than 3 hours, when the amount of poison
35 ml-8
536-9
6Temperature, °37°+3
7The hemoglobinuriano-4
8Laryngeal edemano-2
AMOUNT"-34"

Table 4

Assessment of the patient B. with acute poisoning acetic acid
No.Symptom present in the patientScore
1HemolysisYes+3
2OliguriaYes+6
3Ecotoxicity shockno-2
4The dose-exposure time"Exposure time for more than 3 hours, when the amount of poison
50 ml-8
5Age, years77+5
6Generator, °37,5°+3
ÈA;
7The hemoglobinuria+4
8Laryngeal edema+4
AMOUNT"+15"

Table 5

Determination of need for intensive care manual patient B. with acute poisoning acetic acid
No.Sign existing patientScore
1Esophageal-gastric bleeding+13
2Vomitingmultiple blood+12
3Hemolysis+4
4Dose (regardless of exposure)50 ml0
5The hemoglobinuria+7
6Ecotoxicity shockno-1
7The body temperature of the patient °37,5°-4
8Oliguria+6
9 Laryngeal edema+4
AMOUNT"+41"

Table 6

Assessment of the patient's condition that is acute poisoning acetic acid
No.Symptom present in the patientScore
1HemolysisYes+3
2OliguriaYes+6
3Ecotoxicity shock+10
4The dose-exposure time"Exposure time for more than 3 hours, when the amount of poison
>100+9
5Age, years40-9
6Temperature, °Up to 37°+3
7The hemoglobinuria+4
8Laryngeal edema+4
AMOUNT"+30"

Table 7

Determination of need for intensive care manual patient that acute poisoning acetic acid
No.Sign existing patientScore
1Esophageal-gastric bleeding+13
2Vomitingmultiple blood+12
3Hemolysis+4
4Dose (regardless of exposure)200 ml+10
5The hemoglobinuria+7
6Ecotoxicity shock+12
7The body temperature of the patient °36,7°C.+2
8Oliguria+6
9Laryngeal edema+4
AMOUNT"+70"

The way of medical care to patients with acute oral poisoning with acetic acid at the prehospital stage, characterized by the fact that when referring a patient for medical what omashu determine the dose-exposure", age, hourly diuresis, the presence of hemolysis, ekzoticheskogo shock, laryngeal edema, hemoglobinuria, measure the temperature of the body, each symptom scored, namely: the presence of hemolysis was evaluated as "+3" points, its absence as "-9" points; hourly urine output less than 30 ml/h was evaluated as "+6" points, more than 30 ml/h as "-5" points; the development ekzoticheskogo shock was evaluated as "+10" points, its absence as "-2" point; the dose-exposure less than 3 hours and the volume to 50 ml estimate as "-4" grade "dose-exposure less than 3 h, and the volume from 50 to 100 ml as "+2" points "dose-exposure less than 3 h, and the volume of >100 ml as "+6" points "dose exposure over 3 h, and the volume to 50 ml as "-8" points, "dose exposure over 3 h, and the volume from 50 to 100 ml as "-2" grade the dose-exposure of more than 3 h, and the volume of >100 ml as a+9 points; age (years) 40 assessed as "-9" points, from 40 to 70 as "+2" points, >70 years as "+5" score; body temperature normal evaluated as "+3" points, 37°C as "+3" score, >37°C as "-6" points; the presence of hemoglobinuria evaluated as "+4" points, its absence as "-4" points; the presence of laryngeal edema was evaluated as "+4" points, its absence as "-2" score obtained data is summed and a score of less than "-17" the forecast is favorable, linear brigade conduct lavage of the stomach, pain management, introduction of antispasmodics and corticosteroids, carry out the transportation of the patient the hospital, if the score from "-17" to "+23" prediction of outcome remains in doubt, with the possibility of death, with a score of more than "+23" the prognosis is poor in the last two cases, determine the dose of poison, regardless of exposure, vomiting and her character, the presence of esophageal-gastric bleeding, hemolysis, oliguria: laryngeal edema, ekzoticheskogo shock, hemoglobinuria, measure the temperature of the body, each symptom scored namely esophageal-gastric bleeding was evaluated as "+13" points, no "-2" points; no vomiting was evaluated as "-3" grade single vomiting as "-3" points, repeated vomiting as "+8" points, once with blood as "+5" points, multiple blood as "+12"; the absence of hemolysis was evaluated as "-7" presence "+4" score; dose of poison 30 ml estimate as "-6" of points from 3 to 50 ml as 0 points, from 50 to 100 ml as "+5" points, >100 ml as "+10" points; the presence of hemoglobinuria evaluated as "+7" points, no "-2" points; ekzoticheskogo shock was evaluated as "+12" points, no ekzoticheskogo shock as "-1" point; the body temperature of the patient to 37°C evaluated as "+2" points, temperature 37°C as "-4" grade body temperature of the patient more 37,0°C as "-6" points; the presence of oliguria was evaluated as "+6" points, no "-2" points; the presence of laryngeal edema assess to what to "+4" grade no "-2" score obtained data summarize, if the score is less "-20" linear brigade SMEs are sedation and lavage of the stomach, followed by hospitalization of the patient, when the score of "+20" linear team operate specialized call resuscitation team SMP "on", which is quiesced state and transport the patient to the nearest emergency room, and before the arrival of the resuscitation team line team are sedation, analgesia, sedately, introduction antispasmodics, hemostatic and corticosteroids, puncture of peripheral veins and the start of infusion therapy.



 

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1 ex

FIELD: medicine.

SUBSTANCE: method involves introducing drug of gas transportation activity in distal position with respect to blood circulation arrest place immediately after blood circulation arrest. Perfluoran is selected as the drug of gas transportation activity at a dose not exceeding 30 ml per 1 kg of injured zone mass.

EFFECT: improved oxygen supply to ischemic tissues; reduced risk of reperfusion complications.

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to new compounds of the general formula (I) in racemic form, enantiomer form or in any combinations of these forms possessing affinity to somatostatin receptors. In the general formula (I): R1 means phenyl; R2 means hydrogen atom (H) or -(CH2)p-Z3 or one of the following radicals: and Z3 means (C3-C8)-cycloalkyl, possibly substituted carbocyclic or heterocyclic aryl wherein carbocyclic aryl is chosen from phenyl, naphthyl and fluorenyl being it can be substituted, and heterocyclic aryl is chosen from indolyl, thienyl, thiazolyl, carbazolyl, or radicals of the formulae and and it can be substituted with one or some substitutes, or also radical of the formula: R4 means -(CH2)p-Z4 or wherein Z4 means amino-group, (C1-C12)-alkyl, (C3-C8)-cycloalkyl substituted with -CH2-NH-C(O)O-(C1-C6)-alkyl, radical (C1-C6)-alkylamino-, N,N-di-(C1-C12)-alkylamino-, amino-(C3-C6)-cycloalkyl, amino-(C1-C6)-alkyl-(C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C1-C12)-alkoxy-, (C1-C12)-alkenyl, -NH-C(O)O-(C1-C6)-alkyl, possibly substituted carbocyclic or heterocyclic aryl; p = 0 or a whole number from 1 to 6 if it presents; q = a whole number from 1 to 5 if it presents; X means oxygen (O) or sulfur (S) atom n = 0 or 1. Also, invention relates to methods for preparing compounds of the general formula (I), intermediate compounds and a pharmaceutical composition. Proposed compounds can be used in treatment of pathological states or diseases, for example, acromegaly, hypophysis adenomas, Cushing's syndrome and others.

EFFECT: improved preparing method, valuable medicinal properties of compounds and composition.

11 cl, 2 tbl

FIELD: medicine.

SUBSTANCE: remedy comprises mixture of phytoecdysteroids of 20-hydroxyecdysone and 25S-inocosteron extracted from aerial plant top of Serratula genus of Asteraceae family, preferably from leaves gathered in vegetation phase, mass budding phase or at the beginning of flowering.

EFFECT: enhanced effectiveness of treatment; wide range of medical applications.

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of a curative-prophylactic preparation based on vegetable and animal components with broad spectrum of the pharmacological effect. The curative-prophylactic composition possessing with the general tonic and rejuvenating effect comprises sea urchin sublimated roe, brown algae sublimated fragments from sea urchin cavities, sea urchin sublimated intracavitary liquid and sublimated laminaria chosen in the definite ratio of components. The curative-prophylactic composition is prepared in the form of powder, capsule or tablet. The preparation normalizes the metabolic processes under extreme metabolic conditions.

EFFECT: valuable medicinal properties of composition.

2 cl, 2 ex

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to new compounds of the formula (I) inhibiting tumor growth and angiogenesis wherein each R2 and R3 represents independently hydrogen atom (H), (C1-C4)-alkyl; each X2 and X3 represents independently (C1-C4)-perfluoroalkyl; A represents hydrogen atom (H) or a covalent bond; t represents a whole number 0 or 1 under condition that if A represents hydrogen atom (H) then t = 0, and if A represents a covalent bond then t = 1. Also, invention relates to a pharmaceutical composition and method for inhibition of the tumor growth.

EFFECT: valuable medicinal properties of composition.

32 cl, 3 sch, 5 dwg, 19 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with the way for rapid removal of stresses and/or preventing diseases caused by different stress situations. It is necessary to apply yeast-free breads of "Thibet" type in patient's nutrition. For this purpose, in case of any stress situation during 3-4 min one should chew about 30-50 g bread of "Thibet" type to be swallowed then, and then this procedure should be repeated 30-40 min later, and then it should be again repeated in the same period of time. Thus, the innovation enables to improve body immune values and working capacity, normalizes metabolism and energy exchange due to decreasing aftereffects of physiological and digestive stress.

EFFECT: higher efficiency.

1 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of medicinal agents based on natural components showing the broad curative effect. Invention proposes a pharmaceutical composition for oral using that possesses immunotropic and adaptogenic activities and comprises bee mother milk, Eleutherococcus senticosus plant extract and milkwax stage of oat ripeness tincture. Proposed agent doesn't cause adverse effects and shows the broad spectrum of effect.

EFFECT: valuable medicinal properties of composition.

1 tbl, 2 ex

FIELD: medicine, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the development of medicinal agents of vegetable origin. The medicinal preparation possessing with rejuvenating effect on human body comprises a mixture of dry extracts prepared of grape peel of dark strains, olive tree leaves, rosemary leaves, grape seeds, and also gum arabic and aerosil. The preparation enhances resistance of body against unfavorable environment factors, decelerates ageing processes and stimulates recovery processes of body. Invention can be used for increase of body cells span-life and showing the rejuvenating effect on the human body.

EFFECT: valuable medicinal properties of preparation.

FIELD: veterinary science.

SUBSTANCE: the suggested preparation includes laevomycetin 5.0 g, oxytetracycline hydrochloride 5.0 g, 1,2-propylene glycol 75 cm3, magnesium chloride 0.9 g and polyethylenoxide up to 100 cm3. In case of bronchopneumonia in calves one should inject the preparation suggested intramuscularly at the dosage of 0.3-0.4 ml/kg animal's body weight twice at an interval of 48 h. The preparation in question causes no negative impact upon animal body and has got no side effects.

EFFECT: higher efficiency of therapy.

3 ex, 4 tbl

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