Method for treating children in case of chronic viral hepatitis at applying sulfide baths and low-carbonate mineral water

FIELD: medicine, pediatrics.

SUBSTANCE: children should take sulfide baths and for inner intake - warm low-carbonate chloride-hydrocarbonade sodium-calcium water of low mineralization per 100-200 g depending upon patient's age, for 30 d. The innovation provides improved clinical and paraclinical values due to combined intake of sulfide baths, that stimulate nervous centers through vast cutaneous receptor fields, and drinking water of concrete ionic composition and mineralization degree that decreases activity of all enzymatic systems of gastro-intestinal tract, hepatic among them.

EFFECT: higher efficiency of therapy.

2 ex, 3 tbl


The invention relates to medicine, namely to children's balneotherapy. Closest to the claimed is a well-known application of sulfide baths in combination with drinking sulfide water source No. 16, where the concentration of hydrogen sulfide exactly 10 mg/l (Jn. letter to help practitioners resorts, Pyatigorsk, 1990). These studies concerned the rehabilitation of patients after viral hepatitis A. Our research has shown that a combined application of the sulfide bath and sulfide water for drinking is not shown to children with hug even in the phase of minimal activity. In sulfide baths, where the hydrogen sulfide content is minimal, the hydrogen sulfide is rapidly destroyed and therefore harmful effects on the liver does not have. The use of sulfide water inside children with hug causes the activity of enzyme systems of the gastrointestinal tract, including the liver, in children, increased alkaline phosphatase, ACT, ALT. The essence of the invention lies in the fact that children with hug assigned sulfide baths with a minimum content of hydrogen sulfide and Slavophile chloride-hydrocarbonate-sodium-calcium water East. No. 24, warm (Pyatigorsk Seltzer). It is known that when applied externally sulfide water have on the human body multilateral action. When bathing in mineral water comes in contact with the skin, with extensive receptor field, across the irritation which the external environment is passed to the corresponding nerve centers. In addition, the ingredients of mineral water through the skin and the respiratory tract penetrate into the internal environment of the body and cause irritation interoreceptors internal organs. Chemical and thermal factors determine the response of the organism to these stimuli.

Our proposed method is carried out as follows: the intake of mineral water Slavophiles chloride-hydrocarbonate sodium-calcium low salinity - 4.5 g/l (Pyatigorsk East. No. 24), diet, physical therapy. The child accepts the sulfide bath (Pirogovskaya with hydrogen sulfide content of 10 mg/l).

In the last decade, chronic viral hepatitis deserves the most careful attention, as it causes incapacitation. Data from the scientific literature in recent years claim that viral hepatitis b, C, D, sick 1/3 of the globe, and therefore the urgency of the problem came in 1st place, ahead of AIDS. Every year from hepatitis kills about 1 million people.

Treatment with interferons allows to achieve a temporary remission in 30-40% of patients, combined treatment with lamivudine and rib prolongs remission in 60% of patients. The treatment is extremely expensive and inaccessible for the majority of the population. In this regard our study are quite significant.

The method is illustrated by the following examples.

N is the appropriate 1. With s Magomed 15 years, history 213/815 do in the clinic 29.01.2003, were discharged 27.02.2003, Complaints upon receipt of pain in the right hypochondrium before eating, nausea, constipation, loss of appetite, fatigue. Sick from 7 years of age, was treated in hospital, had been diagnosed with the disease Hungary. For the first time was tested for markers of hepatitis detected carrier of viral hepatitis b+D, received symptomatic therapy. In 2002, was treated at children's sanatorium in Yessentuki with a positive result. Early analysis without features. Admission: General condition average, expressed in the symptoms of chronic intoxication, pale, iparioli the hard palate and sclera, skin visible traces of scratches. Tongue coated dirty-white bloom. The abdomen is soft, painful in the right hypochondrium, so Kera. The liver acts of the rib for 3 cm, painful. Visually the thyroid gland is increased to the I-II century From other organs and systems no visible pathology.

Ultrasound 18/II-2003 - liver enlarged 142-51 mm, mosaic.

Eographically the study of the liver before and after treatment without the dynamics of the blood vessels reduced vascular tone right elevated ECG without pathology.

Prothrombin time before treatment 87,9% after 78%. Total bilirubin 23,0 m/l, ALT 0,218 mccam/l, ACT 0,112 mccam/l thymol test 4,8, total bilirubin after treatment 16,1, ALT 0,299, ACT 0,124, t is Malova sample of 3.7.

Alkaline phosphatase before treatment 209,9 u/l after - 1032 u/l, total protein before treatment 60 g/l after treatment - to 63.8 g/l, albumin, respectively 61,2% - 59.3 per cent.

Diagnosis: chronic viral hepatitis b+D, the minimum level of activity, eateries I class.

In the clinic the child received nutritional therapy (table No. 5), sulfide water sulphate-hydrocarbonate calcium-sodium mineral water (salinity of 4.5 g/l sulfide - 10 mg/l), Pyatigorsk source No. 16, exercise therapy, therapeutic tyubazhi during the month 2 times per week and basic therapy - sulfide baths (Pirogovskaya), t=37°C, duration 15 minutes, every day, on course No. 8.

After the treatment has improved the overall health of the child, improved appetite, increased emotional tone, no pain in the abdomen, nausea, normalized stool, however, objective clinical data has not changed: the liver remained the same size, has not changed the ultrasound results and gametogony. Decreased prothrombin time with 87,9%to 78%; ALT increased from 0,218 to 0,799, ACT with 0,112 to 0,124, Alp with 209,9 to 1032 E/L.

Decreased total bilirubin, thymol test.

Thus, the known method is not prescribed to children suffering hug even with minimal activity, not shown inside sulfide water, therefore we used another method - sulfide baths and inside slabo legisla chloride-hydrocarbonate-sodium-potassium mineral water East. No. 24 (mineralization 4.5 g/l).

Observation 2. S-VA Zalina 7 years, the case history No. 1545/14. Was admitted to the hospital on August 3, 2003 with complaints of pain in the abdomen, reduction of appetite, retarded physical development. The infant was often sick with various diseases, about which he conducted many infusions. The mother believes her sick with hepatitis 2 years, when he was diagnosed with an enlarged liver.

From history: was born at term with a weight of 3200 B.C. year of psychophysical development is age appropriate.

The disease: frequent colds, laryngotracheitis, 2 broken limbs. Brother hepatitis "B".

Admission: General condition is satisfactory, the right physique, low power. Pale skin, under-eye shadows, behind in growth. The lungs and heart without features, tongue coated dirty-white bloom. The abdomen is soft, painless in the right hypochondrium. The liver is under Ribera 3 see, dense. Emotionally labile.

Clinical indicators: ultrasound from 08.08.2003, liver 8E 124 mm, SS - 31 mm, echostructure fine, gall bladder 52×19 mm; wall up to 4 mm, the precipitate is a small number. Mud is not increased. Conclusion: echoprint hepatitis, GIT on hyponatremia type.

REG liver from 20.08 - blood pressure is reduced, to the right. increased venous outflow difficult is Yong.

ECG from 12.08. - marked sinus arrhythmia, violation of repolarization in paradisevalley area.

ALT 0,283 IADS member/l, ACT 0,226 IADS member/l, sublimate sample 96%, thymol 0.7 services. units, serum cholinesterase 0.78 services. units, gamma - GTP 0,6 IADS member/l; alkaline phosphatase - 495,2 u/l, cholesterol 4.26 deaths mmol/l, total protein 69%, G - 54,1, α1 globulin of 5.4%, α2-globulin 10,8%,-globulins of 12.6%, G-globulins of 17.1%.

PAG-0, creatore, amenorea, steatorrhea, acidic diarrhea.

Revealed a flat curve with a load of lactose (3,61; 4,53; 4,46)

In General, the analysis of blood and urine pathology no. After treatment has changed clinical indicators: decreased liver size up to 1.5 cm, REG disappeared venous congestion, ECG is unchanged, decreased ALT with 0,283 to 0,126 IADS member/l, ACT with 0,226 to 0,146 IADS member/l, alkaline phosphatase with 495,2 u/l up to 437 u/l, increased albumin with 54.1 per cent to 56.6%, increased the activity of trypsin in Calais from 0 to 1:40 (breeding), disappeared creatore, steatorrhea, amylacea.

She was discharged after 30 days with the improvement of the General condition of vanished abdominal pain, appetite improved, gone are the symptoms of chronic intoxication became more emotional, active. The liver decreased from +3.0 to +1.5 cm In a REG disappeared venous congestion, gone are the symptoms of cytolysis, cholestasis, mesenchymal inflammation, improved the function of the pancreas (increased activity of trypsin at Calais). Digestion - gone is ruatoria, amylacea, steatorrhea.

Thus, a single treatment in the clinic with the use of sulfide bathing and drinking Slavophiles chloride-hydrocarbonate-sodium-calcium water in the background diet contributed to the improvement of General condition, clinical and paraclinical parameters.

Thus, the proposed method, i.e. sulfide baths and Slavophile water, have an advantage over the previously described method and oprobirovanii us in children with hug. This gives us reason to believe that patients hug, in the phase of clinical and laboratory remission can be rehabilitated at the resort, revealed the advantage of the proposed method before known. The feature of the proposed method is that sulfur contained in the bath, could be a supporting factor for the liver, in the first minute breaks, and carbonated mineral water practically does not contain sulfur, as shown in the examples (see table 1-3).

Table 1
Clinical characteristics of groups
SignThe known method n=24%The proposed method for n=10%
FloorD19 (80%)7(70%)
Disease duration5 years10(40%)5(50%)
over 7 years14(60%)5(50%)
The degree of activityInactive2(8,3%)1(10%)
Minimum (I century)22(91,7%)9(90%)
Table 2
Dynamics of clinical indicators
Signs of illnessKnown

method n=24 (points)

Method n=10
D/lP/lPD/l P/lP
Abdominal pain2,29±0,20,45±0,5=0,0011,66±0,40,6±0,02=0,02
Symptoms of XP. intoxication6,0±0,053,0±0,010,056,5±0,052,5±0,01<0,001
Coated tongue2,95±0,90,29±0,009=0,010,35±0,030,01±0,001<0,001
HC. liver 1,58±0,061,13±0,05>0,5was 2.76±0,471,25±0,25=0,02

Table 3
Dynamics laboratory parameters of children, the sick hug, in the course of treatment.
IndexThe known method n=24The proposed method for n=10
The cytolysisALT0,25+0,030,23+0,03>0,050,160+0,110,11+0,03<0,5
Maseng. FOTS.NV118,95+5,56105,54+9,9>0,050,14,5+0,7to 126.8+6,9<0,05
Erythrocyte sedimentation rateof 5.83+0,074,08+5,5>0,05---
Thymol test4,51+0,73,7+0,6=0,1 2,62+0,98to 2.06+0,9=0,5
Ave. beat.2,08+0,91,23+0,5=0,11,24-0,081,1+0,5=0,5
Hepatomas. syndromePETIT03,3+7,756,9+of 8.47>0,0587,4+2,991,0+0,83=0,01
The cholesterol.4,49+0,243,75+0,48=0,2---
Albumin54,2+2,449,64+3,9=0,555,9+1,1456,5+0,56 =0,5
D/l before the treatment
P/l after treatment
R - reliability of differences
All groups randomination

Treatment of children with chronic viral hepatitis, sulfide baths and mineral water, characterized in that the mineral water children take warm libopenal chloride-gidrokarbonatno sodium-calcium water of low salinity 100-200 g depending on the age within 30 days.


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