Method for preventing post-injection necrosis

FIELD: medicine, therapy.

SUBSTANCE: the present innovation deals with preventing post-injection necrosis of soft tissues as a result of false subcutaneous injection of 10%-calcium chloride solution. One should detect the volume of the introduced 10%-calcium chloride solution; then it is necessary to introduce 5-fold volume of 5%-sodium citrate solution against the volume of calcium chloride injected; then one should apply a sac with ice onto the site of injection for the period of 30 min, not less. The innovation suggested enables to inhibit the processes for tissue damage due to binding calcium cations with anions of sodium citrate along transforming soluble calcium salt into insoluble one to stop calcium transport into the cells and, thus, prevents its damaging action.

EFFECT: higher efficiency.

1 ex

 

The invention relates to medicine, in particular to therapy and clinical pharmacology, and can be used in intravenous injections of calcium.

Known way to prevent injection necrosis caused by erroneous introduction under the skin of a solution of calcium chloride by leaving the needle at the injection site, detach from her syringe injection through it into the fiber of the second syringe initially 5-10 ml of physiological solution, and then 10 ml of 0.25% solution of novocaine, and then on the affected area impose a compress was applied (Mylnikov I.S. Ward nurse. M: Grand, 1998, p.153).

The disadvantage of this method is low efficiency and safety of tissue protection. The fact that the introduction in the area of infiltration caused by injection of a 10% solution of calcium chloride, 5-10 ml of saline solution or 10 ml of 0.25% solution of novocaine, containing additional quantities of calcium ions causes extra calcium damage obkatyvaem region, complemented by hydrodynamic excessively large volume of solution, infiltrating tissue. In addition, the subsequent imposition was compress causes short term slight cooling of the body surface, very soon replaced by a warm-damaged (inflamed) about the region due to the irritant action of alcohol and heat-insulating functions of the compress, that speeds up the metabolic processes underlying inflammatory damage, increases the need for tissue oxygen, stimulating aerobic processes in the mitochondria and promotes oxygen and volatile penetration into them of the cations of calcium, which estranges breath with oxidative phosphorylation like the disconnector dinitrophenol and cause irreversible calcium damage to the mitochondria. Inside the mitochondria damage processes is manifested as a feeling of heat and burning sensation in the field of medical infiltrate tissue and occur due to excess heat production in the mitochondria due to the uncoupling of respiration and phosphorylation.

The purpose of the invention is improving the efficiency and safety protection of tissues from acute injection of calcium damage.

The essence of the proposed method of preventing injection of tissue necrosis caused by the introduction of fibre in the 10% solution of calcium chloride, including the abandonment of the needle at the injection site, detaching from her syringe, introduction through her fibre in the second syringe solution of a drug and subsequent application of fluid to the injection area, lies in the fact that, initially, to determine the volume of solution of 10% calcium chloride, is introduced into the fiber, and as a medicinal the CSO funds impose a five-fold volume of a 5% solution of sodium citrate for injection, and as the coolant using an ice pack, which impose for a period of not less than 30 minutes.

In the proposed method by determining the volume of a solution of 10% calcium chloride in the tissue, provide a determination of the optimum amount required inactivator calcium solution of sodium citrate. Introduction to infiltrate formed by solution of 10% calcium chloride, five-volume solution of 5% sodium citrate for injection provides, on the one hand, the complete inactivation of calcium ions medication and fabric of nature, and on the other hand, eliminates the introduction of excessively large volumes of a solution of sodium citrate, which increases the severity and duration of injection of inflammation.

The use of a solution of sodium citrate facilitates the interaction of citric acid (sodium and calcium chloride with the formation of insoluble salts of calcium citrate, which inactivates ionized calcium leads to its disappearance in the area of infiltration, and therefore the transport of calcium into the cells and into subcellular structures, in particular inside the mitochondria, is terminated. This prevents the calcium damaging roles, particularly the role of the disconnector respiration and oxidative phosphorylation in mitochondria, and the role of a confirmatory factor irreversible nature of mitochondria, which is s surrounded by ionized calcium unrestrained absorb it, swell and burst.

Applying to the affected area of the bladder with ice for a period of not less than 30 minutes provides reliable local hypothermia and cold hyperemia, which allows you to slow down the processes of tissue damage and to improve the diffusion of the solution by increasing blood flow.

Example 1. The patient P. in polyclinic conditions was appointed intravenous injection of 10 ml of 10% solution of calcium chloride in the region of the left cubital vein. When the procedure is executed after intravenous injection of 1 ml of solution a nurse suspected a drug by vein, so she stopped the introduction of the remaining volume of the solution. Ultrasonic examination of the injection site confirmed the presence of drug infiltration volume of about 1 ml per injection site. The needle was left in place, disconnected from the syringe, put the second syringe through the left needle to the area of the injection of 5 ml of 5% solution of sodium citrate for injection, after which the affected area put an ice pack on 35 minutes. Produced after this revision using ultrasound studies have established a complete absence of medical infiltrate at the site of injection.

The way to prevent injection of tissue necrosis caused by the introduction of fiber 10%R is the target of calcium chloride, including leaving the needle at the injection site, detaching from her syringe, the introduction of the second syringe through left the needle in the tissue of a solution of a drug and subsequent attachment of the carrier to the area of injection, characterized in that, initially, determine the volume of a 10%aqueous solution of calcium chloride, and then as a drug injected 5%solution of sodium citrate in a five-fold volume, and as the coolant using an ice pack, which impose for a period of not less than 30 minutes



 

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