Anti-inflammatory ointment with hypolipidemic effect
FIELD: medicine, pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to an anti-inflammatory ointment with hypolipidemic effect. Proposed ointment comprises ephthylline-base for ointment, a statin wherein lescol (fluvastatin) is used as statin, and ephthylline comprises 40% of ephthiderm. Invention provides enhancing the curative effect and hypolipidemic effect and effects on enzymatic systems of biological membranes that results to prolongation of curative effect of ointment.
EFFECT: valuable medicinal properties of ointment.
3 cl, 2 tbl
The invention relates to medicine, specifically to anti-inflammatory remedies for external use. The tool can be used in the treatment of hyperlipidemia any origin, including in combination with coronary heart disease (CHD) and hypertension (GB).
There are a large number of drugs anti-inflammatory action, for example - NSPs [Ivanova L.A., Kopteva EJ, 1991; Klyuev M.A. and others, 1990; Mashkovsky PPM, 1993; Nasonova V.A., Astapenko M.G., 1989; Nelyubov M.V. and others, 1998; Orlov, T.V., 1990; Ackerman, S.J. et al., 1983]. Unfortunately, they all have side effects. First of all, it ulceration of the mucous membrane of the stomach and duodenum, which may be accompanied by bleeding; damage and necrosis of the kidneys, delay delivery [Dale M.M. j shaped. To; Mashkovsky PPM, 1993; Adams D.O., Hamilton T.A., 1988].
Closest to the patent-pending tool is ointment anti-inflammatory eftimation containing etterlin (application No. 2003131288 from 28.10.2003 - prototype). This ointment has no lipid-lowering effect.
On the other hand, well-known drugs statins, which inhibit the synthesis of cholesterol and lower the levels of low density lipoprotein (LDL) in the blood, eliminating hyperlipidemia. It is recommended to use these drugs in the form of tablets or capsules constantly throughout life. Unfortunately, the due to their high cost they are not available for most patients. In addition, the daily dose of statins variable, as is the accumulation of the drug in the body and changes its activity [Avesco and others, 2001, Mhglte, Kaabeli, Lgeria, 1999; W.J.Patrick, .Serruys, 2002].
The technical challenge is to improve therapeutic effect of the ointment on the basis of afterline with achievement of the lipid-lowering effect.
The technical result is achieved by the fact that anti-inflammatory ointment containing afterin add a statin, such as lescol, in the following ratio, wt.%:
The invention is also characterized by the fact that the ointment (afterin) contains 40% epiderma.
The technical result is ensured by the ability of epiderma conduct biologically active substances through the skin and mucous membranes. It also has anti-inflammatory and high antioxidant activity; increases oxygenation (oxygen regime) tissues; increases cell viability; the effect on the enzymatic system of biological membranes, which leads to the enhancement and prolongation of therapeutic effect of all components of the ointment.
The obviousness and sverhsummarny effect of the proposed technical solutions SOS is the RTO is what afterin, preserving all properties epiderma, not only easily holds a statin in the tissue, but also extends it for 22-26 hours. This afterin significantly enhances the activity of the statin, which allows you to reduce the dose in the last fifty or more times (usual daily oral dose 10-160 mg statin, and 100 g of ointment contains 160 mg of a statin at a daily dose ointments for external use is 0.5-2 g, which contained only 0.8 to 3.2 mg statin).
The mechanism of action of statins: lovastatin (mevacor), simvastatin (zocor), pravastatin (lipostat), fluvastatin (lescol), atorvastatin (Liprimar), based on the fact that they have a chemical structure similar to HMG-COA reductase, which catalyzes the synthesis of cholesterol from acetic acid via the formation of avalonbay acid. Statins, superseding the true enzyme, interrupting the path of education avalonbay acid and thereby inhibit the synthesis of cholesterol in the liver, resulting in their level in the blood drops.
The feasibility of the present invention proves a specific example of obtaining ointments on the basis of afterline content 0,160% of the statin lescol (fluvastatin), called "Attestat". Instead of lescol in the proposed ointments you can use other known statins: mevacor (lovastatin), or zocor (simvastatin), or lipostat (pravastatin), or lindens who IMAR (atorvastatin). You get a ointment with similar therapeutic effect.
To get proposed as the object of a patent anti-inflammatory ointment AFRISTAT use the following ingredients:
- attilly on FS 42-3809-99 in the form of ointment.
- Statin (lescol-fluvastatin) in the idea of a powder or granules
Per. No. in Russia: Novartis Pharma AG (Switzerland) 008833 from 16.12.1998 g Novartis Farmaceutica S.A. (Spain) 011859/01-2000, 17.04.2000,
For more ointment into the pot stirrer and homogenizer load 75% of the required number afterline.
Statin pounded into fine powder, sieved through sieve No. 38, weighed on an analytical balance in the right quantity, then carefully rubbed with epilinum in the ratio of at least 1:10 and fed into the boiler, followed by stirring for 5-7 minutes.
In the resulting mass is added to the desired amount afterin and mix thoroughly for 15 to 20 minutes to form a homogeneous mass of light-yellow or light yellow with a greenish tint, with low specific smell.
Ointment AFRISTAT applied to the skin in the area of the carotid arteries (lateral surface of the neck) 1 time per day in the amount of 0.5 to 2.0,
When the content of the statin in ointments less 0,080% specific action moderately expressed, and when its content is more 0.240% of the effect is not practically increase the W (the difference between false). The best is the concentration 0,160%.
The composition of the studied compositions shown in table 1.
Previously conducted experimental tests on animals, which allowed to determine the optimal composition of the ointment, which was named "Attestat". It was found that the proposed anti-inflammatory ointment does not have acute and chronic toxicity, local irritant effect, not cumulated, not a potential allergen. Confirmed anti-inflammatory ointments, especially in animals 2 and 5 groups. In addition, it should be noted their high anti-edema effect.
|Studied composition ointment|
|Lescol - fluvastatin||Lipostat - pravastatin|
The study was conducted on 70 Mature white rats with severe experimental hyperlipidemia, distributed into 7 groups of 5 males and 5 females in each. Animals within 30 days applied the ointment, according to the group 2 area of the skin in the area of the carotid arteries in size 2×2 cm once a day. Before the beginning of the experiment and the next day after it investigated the peripheral blood, and performed biochemical analysis of blood serum. Below are some data obtained in animals 2, 5 and control (7) groups (see table 2).
From these data suggest that statins concentration 0,160% significantly reduce hyperlipidemia, including total lipids 8.7 to 12.2%, β-lipoproteins on 17,74-22,56%. At the same time cholesterol is reduced by 12,95-16,07%, and the viscosity of the serum 17,44-22,05%.
|The parameters of blood serum of rats in the dynamics|
|№ p/p||Impact||Term studies.||Blood lipids, mg %||β-lipoprotein, mg %||Cholesterol, mg %||Viscosity|
|Note. Significant values at p≤0.05 is marked with *.|
The comparison is carried out with the parameters of the control group.
To research all figures are based on 70 animals.
On the basis of the obtained data was prepared in a pharmacy by way ointment AFRISTAT for klinicheskoj the application.
Here are clinical examples of the use of the ointment AFRISTAT for local treatment.
1. Patient P., 52, within 10 years, suffering from essential hypertension stage 3, coronary heart disease (CHD) in the form of strokes voltage 1-2 F.K. Despite intensive treatment and compliance hypocholesterolemia diet, identified elevated levels of total cholesterol to 6.8 mmol/l, low density lipoprotein - cholesterol of 4 mmol/l, triglycerides - to 3.36 mmol/l, decreased high density lipoprotein - HDL to 0,684 mol/L. When performing duplex scanning of the carotid arteries detected seal intima in the proximal internal carotid artery local atherosclerotic plaques, stenocereus the lumen of the vessel to 20%. On the background diet compliance hypocholesterolic the patient was prescribed a course of local therapy AFRISTAT (lescol 160 mg per 100 g of ointment). It is recommended to apply 2 g ointment on the night of the carotid arteries. After 4 weeks the biochemical analysis of blood: total cholesterol - 4,94 mmol/l, triglycerides - to 2.42 mmol/l, LDL - 3.1 mmol/l, HDL - 0,76 mmol/L. Duplex scanning of the carotid arteries: the thickness of the intima-media of the common carotid arteries less than 0.9 mm in the proximal internal carotid artery atherosclerotic plaques, stenocereus clearance to 11.9%.
2. Patient S., 71,, for m is ogic years, suffering from essential hypertension stage 3, risk group 4, CHD, painless form of ischemia in type 2, dyslipidemia 2A type. Admission: total cholesterol was 7.3 mmol/l, LDL - 5.7 mmol/l, HDL - 1.05 mmol/l Duplex scanning of the carotid arteries: the intima-media of the common carotid arteries thickened to 1.4 mm, at the mouth of the right subclavian artery, atheromatous plaque, stenoziruyuschaya the lumen of the vessel up to 35%, in the region of the carotid bifurcation - the atherosclerotic plaque with stenosis of up to 40%.
Were assigned to the treatment: hypocholesterolemia diet, Renitec 10 mg bisoprolol 5 mg, aspirin 0,125. When re-examination after 4 weeks of positive changes in the lipid spectrum of blood did not happen. Further appointed local therapy AFRISTAT (lescol 160 mg per 100 g of ointment). It is recommended to apply 2 g ointment on the night of the carotid arteries. After 1 month of local therapy studies: total cholesterol 5,61 mmol/l, LDL a 3.87 mmol/l, HDL-C increased 1.58 mmol/l After 12 weeks of treatment: total cholesterol - 3.9 mmol/n, LDL - 2.2 mmol/l, HDL - 1.6 mmol/l, duplex scanning of the carotid arteries: the reduction of the thickness of the intima-media to 0.9-1.0 mm, stenosis atherosclerotic plaque decreased, the lumen of the right subclavian artery is 98% of normal.
3. Patient A., 55 years. For a long time suffers from high blood pressure, coronary artery disease. In 2002 he suffered acute infer the t of the myocardium, in the same year is an acute disorder of cerebral circulation, within 3 years diagnosed dyslipidemia 2-b type. Takes treatment, observes hypocholesterolemia diet. Repeatedly cardiologist recommended taking statins. However, due to their high cost, the patient was unable to buy them. The hospital was assigned the rate of local therapy attestator (lescol 160 mg per 100 g of ointment). It is recommended to apply 2 g ointment on the night of the carotid arteries. Before treatment total cholesterol was 5,61 mmol/l, triglycerides - to 3.02 mmol/l, LDL - 3,59 mmol/l, HDL - 0,656 mmol/l, haemoglobin rate - 7,6; ultrasonic examination of the intracranial arteries revealed thickening of the intima-media of up to 2 mm, in the course of the carotid arteries lazerous single atherosclerotic plaques, stenocereus the lumen of a vessel of up to 15%.
After 4 weeks of treatment, total cholesterol was 4,48 mmol/l, triglyceride is 1.91 mmol/l, LDL - 2,85 mmol/l, HDL - 0,755 mmol/l After 12 weeks of treatment: total cholesterol was - 3.54 mmol/l, triglycerides - is 1.81 mmol/l, LDL - of 1.93 mmol/l, HDL - 0.78 mmol/l, haemoglobin rate - 3,53; duplex scanning of the carotid arteries-the thickness of the intima-media of 0.9-1.0 mm, plaques not lazerous.
So, experimental animal testing allowed us to determine the Optima is capacity composition of anti-inflammatory ointment AFRISTAT. It is established that the ointment does not have acute and chronic toxicity, local irritant effect, does not accumulate in the body, is not a potential allergen.
Experimentally in animals and clinically confirmed the positive effect of the ointment, the anti-inflammatory activity. Performed posed technological challenges, i.e. achieved a pronounced hypolipidemic effect of the proposed anti-inflammatory ointment.
It is proved that the statin drug in the form of ointment, much cheaper than tablets or capsules. Thus, when the maximum local application of ointments (2 grams per day, containing 3.2 mg statin), its consumption is only 60 grams per month, i.e. the consumption of statins decreases in comparison with oral way (depending on dosage) in 3-750 times while maintaining therapeutic effect. It makes available a wide statin drug in the form of ointment for the treatment of patients both in the inpatient and outpatient settings.
Given the above, we can conclude that the proposed anti-inflammatory ointment meets the criteria of novelty, non-obviousness and industrial applicability.
Thus, the obtained anti-inflammatory ointment with hypolipidemic effect called AFRISTAT, which is offered to the legal protection of a patent for an invention.Sources of information
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1. Anti-inflammatory ointment with hypolipidemic effect, containing afterin, characterized in that it contains afterin basis for ointments and statin in the following ratio, wt.%:
|Afterin basis for ointments||99,76-99,920|
2. Anti-inflammatory ointment according to claim 1, characterized in that statin use lescol (fluvastatin).
3. Anti-inflammatory ointment according to claim 1, characterized in that afterin contains 40% epiderma.
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new derivatives of piperidine of the general formula (I): or their nontoxic salts wherein R1 represents hydrogen atom, cyano-group; each R2 and R3 represents (C1-C8)-alkyl, (C3-C7)-cycloalkyl and others; each R4 and R5 represents hydrogen atom, (C1-C8)-alkyl and others; R6 represents hydroxyl group, (C1-C8)-alkoxy-group and others; m represents 0 or a whole number 1-4. Compounds of the formula (I) possess inhibitory activity with respect to PDE4 and can be used in medicine in treatment of inflammatory, diabetic, allergic and other diseases.
EFFECT: valuable medicinal properties of compounds.
10 cl, 11 tbl, 111 ex
FIELD: pharmaceutical industry and technology.
SUBSTANCE: invention relates to a method for preparing oily extracts from vegetable raw. Method for preparing gum-tree oily extract involves drying branches with 70% of leaves, not less, to the definite moisture index and milled followed by their treatment with electric activated liquid at the definite pH value and in the definite amount of raw mass at stirring and keeping for a definite time. Then prepared mass is wetted with ethyl alcohol, dried to the definite moisture value and extraction is carried out under definite conditions and filtered. Method allows decreasing extraction time and enhancing the yield of total amount of extractive substances.
EFFECT: improved preparing method of extracts.
5 tbl, 9 dwg, 16 ex
SUBSTANCE: method involves administering fluoroquinolone-series antibiotic like Ciproflaxin at a dose of 100-250 mg twice a day during 3-5 days and non-steroid anti-inflammatory preparation of Diclophenac at a dose of 75-150 mg/day during 3-7 days are sequentially introduced in preparing patient to diagnostic examination.
EFFECT: enhanced effectiveness in increasing method sensitivity.
FIELD: organic chemistry, chemical technology, biochemistry, pharmacy.
SUBSTANCE: invention relates to methods for preparing 2-phenylamino-5-alkylphenylacetic acids of the general formula (I)
intermediate compounds for their preparing, their pharmaceutically acceptable salts and pharmaceutically acceptable prodrug esters wherein R, R1, R2, R3, R4 and R5 have corresponding values. Compound of the general formula (I) is prepared by splitting lactam of the formula (II): wherein symbols have values given in the description with a base, its precursors and methods for preparing these precursors. Abovementioned methods can comprise if necessary the temporal protection of all reaction groups showing effect followed by isolation of the prepared compound. Invention provides preparing compounds of the general formula (I) representing pharmaceutically active compounds that represent selective inhibitors of cyclooxygenase-2.
EFFECT: improved preparing method, valuable biochemical properties of compounds.
10 cl, 1 sch, 9 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new compounds able to prevent the extracellular release of inflammatory cytokines. Proposed compounds including their diastereomeric forms and their pharmaceutically acceptable salts correspond to the formula: wherein R means: (a) -O[CH2]kR3 or (b) -NR4aR4b; R3 means a substituted or unsubstituted (C1-C4)-alkyl, a substituted or unsubstituted phenyl wherein substitutes are taken among halogen atom, cyano-group, trihalidemethyl, (C1-C4)-alkyl, (C1-C4)-alkylsulfonyl, -NR4aR4b, -O[CH2]kR3 wherein R3 means hydrogen atom each among R4a and R4b means independently hydrogen atom or (C1-C4)-alkyl-CO- or benzo(1,3)dioxol; index k has a value from 0 to 5; each among R4a and R4b means independently: (a) hydrogen atom or (b) -[C(R5aR5b)2]mR6 wherein each Ra means hydrogen atom, and R5b means hydrogen atom, linear or branched (C1-C)-alkyl; R6 means vinyl, the group -OR7, -CO2R7, cyclic (C3-C)-alkyl, unsubstituted phenyl or phenyl substituted with (C1-C4)-alkyl, (C1-C4)-alkylsulfonyl, -NR4aR4b, -O[CH2]kR3 wherein each among R3, R4a and R4b means independently hydrogen atom, or unsubstituted 6-membered nitrogen-containing heteroaryl; R7 means hydrogen atom, water-soluble cation or (C1-C4)-alkyl; index m has a value from 0 to 5. Also, invention relates to a pharmaceutical composition comprising the effective dose of compounds corresponding to abovementioned formula, and to a method for inhibition of extracellular release of inflammatory cytokines.
EFFECT: valuable medicinal properties of compounds and composition.
14 cl, 1 sch, 6 tbl, 3 ex
FIELD: organic chemistry, medicine.
SUBSTANCE: invention relates to a new compound, i. e. 3-(4-nitrobenzoylmethylene)-1H,4H-hexahydro-2-quinoxalone of the formula (I) possessing anti-inflammatory activity. Proposed compound possesses the reduced toxicity.
EFFECT: improved and valuable medicinal properties of compound.
2 tbl, 1 ex
FIELD: organic chemistry of heterocyclic compounds, biochemistry.
SUBSTANCE: invention relates to new ortho-substituted and N-substituted indoles of the formula (α): or (β): or their pharmaceutically acceptable salts wherein Z1 represents -CR4 or nitrogen atom (N); R4 means hydrogen atom (H), (C1-C6)-alkyl comprising optionally oxygen atom (O) or nitrogen atom (N) possibly substituted with halogen atom, keto-group, 5-6-membered cycloaliphatic radical possibly comprising 1-2 oxygen atoms (O) or nitrogen atom (N); Z2 represents -CH or -CR wherein R means (C1-C6)-alkyl; R1 means compound of the formula: wherein X1 means -CO or its isostere; m = 0, 1; Y represents alkyl that can be substituted; or two Y form in common (C2-C3)-alkylene; n = 0, 1 or 2; Z3 represents -CH; X2 represents -CH, -CH2 or their isostere; Ar represents one or two phenyl groups bound with X2 wherein phenyl can be substituted; R2 represents hydrogen atom (H), (C1-C6)-alkyl or aryl wherein each aryl comprises, possibly, oxygen atom (O) or nitrogen atom (N) and can be substituted. Proposed compounds are selective inhibitors of p38α kinase.
EFFECT: valuable biochemical properties of compounds.
34 cl, 5 tbl, 23 ex
FIELD: medicine, pharmacology, pharmacy.
SUBSTANCE: invention relates to composition possessing an anti-inflammatory effect and useful for oral administration in form of emulsion preliminary concentrate. Composition comprises NO-releasing nonsteroid anti-inflammatory drug, surface-active substance, oil or semisolid fat and forms in situ emulsion of type oil-in-water after contact with aqueous medium, such as gastroenteric fluid. Also, invention relates to a medicinal formulation based on thereof, oral emulsion, set based on thereof and a method for treatment of inflammation and pain. Proposed compositions possess the improved availability.
EFFECT: improved and valuable properties of composition.
40 cl, 1 tbl, 20 ex
FIELD: medicine, surgery.
SUBSTANCE: since the 2nd d after operation for 2 wk one should prescribe nimesulide per 100 mg twice daily, and on the 7th - 10th d after operation - microwave therapy onto thyroid area at the power of 2.5 W for 5 min at low-thermal mode, moreover, after hemithyroidectomy one should prescribe physiotherapy since the 7th d, after resection of isthmus - since the 8th d, after subtotal resection - since the 9th d, after total thyroidectomy - since the 10th d. The method provides enhanced secretion of thyroid hormones and compensation of hypothyroidism due to physiotherapy, that enables to get rid of hormonal substitution therapy or decrease its dosage.
EFFECT: higher efficiency.
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to derivative of triazaspiro[5.5]undecane of the formula (I): wherein R1 means compound of the formula (1): or (2): wherein G represents a bond, (C1-C4)-alkylene, (C2-C4)-alkenylene or -CO-; ring A represents: (1) C5-10-membered mono- or bicarbocyclic ring or (2) 5-10-membered mono- or bicyclic heterocycle comprising 1-2 nitrogen atoms and/or 1-2 oxygen atoms; substitute R6 means the following values: (1) (C1-C4)-alkyl, (2) halogen atom, (3) nitrile group, (4) trifluoromethyl group and others; R2 represents: (1) (C1-C4)-alkyl, (2) (C2-C4)alkynyl or (3) (C1-C4)-alkyl substituted with a substitute represented in claim 1 of the invention claim; each R3 and R4 represents independently: (1) hydrogen atom, (2) (C1-C4)-alkyl or (3) (C1-C4)-alkyl substituted with 1-2 substituted taken among: (a) Cyc 2 and (b) hydroxy-group (wherein Cyc 2 represents (1) C5-6-membered monocarbocyclic ring or (2) 5-6-membered monocyclic heterocycle comprising 1-2 nitrogen atoms and/or one oxygen atom), or R3 and R4 form in common group of the formula: wherein R26 represents (C1-C4)-alkyl or Cyc 2; R5 represents hydrogen atom or (C1-C4)-alkyl, its quaternary ammonium salt, its N-oxide or its nontoxic salt. Also, invention relates to pharmaceutical composition inhibiting HIV, regulator of chemokine/chemokine receptor and agent used in treatment and prophylaxis of some diseases, such as inflammatory diseases, asthma, atopic dermatitis, nettle rash, allergic diseases, nephritis, hepatitis, arthritis and other diseases that comprise as an active component above described compound of the formula (I) or its quaternary ammonium salt, its N-oxide or its nontoxic salt. Also, invention relates to (3R)-1-butyl-2,5-dioxo-3-((1R)-1-hydroxy-1-cyclohexylmethyl)-9-(4-(4-carboxyphenyloxy)phenylmethyl)-1,4,9-triazaspiro[5.5]undecane or its pharmaceutically acceptable salt and pharmaceutical composition based on thereof, and to (3R)-1-butyl-2,5-dioxo-3-((1R)-1-hydroxy-1-cyclohexylmethyl)-9-(4-(4-carboxyphenyloxy)phenylmethyl)-1,4,9-triazaspiro[5.5]undecane hydrochloride and pharmaceutical composition based on thereof.
EFFECT: valuable medicinal properties of derivative and composition.
16 cl, 32 ex
FIELD: cosmetology, esthetic surgery, applied biopharmacology.
SUBSTANCE: invention relates to medicative and cosmetic agents, and uses of biologically active substances based on natural biological complexes. Claimed method includes application of Mirralgin balm having analgesic, anti-inflammation and resolving action, Reventon balm, having vessel restorative action, for edema reducing and microcirculation improving. In process of blepharoplastic eye boundary bandage microemulsion having recovery and animative action on eaves skin is applied, and in process of facelifting cream mask having bactericide, vessel restorative and recovering action, and enhancing of local immunity is applied. Mirralgin balm and Reventon balm treatment is carried out sequentially or alternatively. In another embodiment after skin cleaning and treatment of damaged zone with anti-septic agent Bacteriophage gel, which disinfects skin surface, prevents biofilm forming, accelerates cicatrizing process is applied, then posttraumatic zone is treated with cleaning milk, toned up with tonic lotion and cream mask having bactericide, vessel restorative and recovering action, and enhancing of local immunity is applied.
EFFECT: method for skin structure recovering without skin trauma.
4 cl, 7 ex, 1 tbl
FIELD: veterinary science, medicine, pharmacy.
SUBSTANCE: invention relates to agents used in treatment of dermatomycosis in animals and humans. Ointment for treatment of dermatomycosis in animals and humans comprises acetylsalicylic acid, 5% iodine alcoholic solution and glycerol taken in the definite ratio of components. Invention enhances effectiveness of treatment, decreases time in treatment of dermatomycosis and prevents appearance of new foci of diseases and relapses.
EFFECT: enhanced effectiveness of treatment.
FIELD: medicine, contraception.
SUBSTANCE: invention proposes antibacterial and contraceptive compositions that comprise the following components: (1) matrix-forming substance; (2) bioadhesive substance; (3) buffer substance; (4) moistening substance, optionally; (5) preserving agent, optionally, and (6) water. Proposed compositions are suitable for their placement into vagina wherein compositions form semisolid matrix in contact with testicular fluid, cause thickening cervical mucus, form a bioadhesive layer on vagina surfaces, maintain the natural acid pH value in vagina about less 5 in the presence of testicular fluid ejected by a male and don't disturb essentially the natural microbiological balance in vagina. Compositions and methods decrease and/or prevent transfer of diseases transferring by sexual way and act as vaginal contraceptives with less adverse effect as compared with conventional vaginal contraceptives and can be used therefore for a long time. Compositions and methods are simple for using and don't require a physical device for their retention into vagina during using.
EFFECT: improved and valuable properties of compositions and methods.
36 cl, 17 tbl, 11 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to an agent for topical using used in treatment of joint diseases. The proposed agent comprises glucosamine salt, chondroitin sulfate and dimethylsulfoxide incorporated into an acceptable ointment base. Invention provides enhancing effectiveness due to using low-molecular saccharides that results to elevating diffusion delivery rate of the substance to the joint zone and providing the achievement of synergistic effect in treatment of joint diseases.
EFFECT: enhanced effectiveness and valuable medicinal properties of agent.
2 cl, 3 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to preparations for external using in treatment of joint diseases. The proposed agent comprises a saccharide - glucosamine salt and dimethylsulfoxide incorporated into an acceptable ointment base. Invention provides enhancing effectiveness of agent due to using low-molecular saccharides that results to the elevating diffusion delivery rate of active substance to the join zone.
EFFECT: improved and valuable properties of agent.
2 cl, 5 ex
FIELD: medicine, dermatology, pharmacy.
SUBSTANCE: invention relates to a pharmaceutical gel composition for applying on skin. The composition comprises at least one vitamin D or analog of vitamin D, at least one corticosteroid, at least one solvent and an excipient enhancing viscosity. Viscosity value of the composition is in the range from 5 mPa x s to 500 mPa x s. The composition is designated for treatment of psoriasis and associated states in humans. The composition is suitable for applying on skin, shows the improved absorption and stable at 40°C in storage for 3 months.
EFFECT: improved and valuable properties of composition.
22 cl, 2 tbl, 1 ex
FIELD: medicine, endocrinology, pharmaceutical technology, pharmacy.
SUBSTANCE: invention relates to nateglynide-containing preparation used in treatment of diabetes mellitus that comprises nateglynide as an active component and a carrier wherein nateglynide in amorphous form and indicated carrier represents hydrophilic material. Amorphous property of crystalline nateglynide is provided by the following methods: 1) by dissolving nateglynide crystals in pharmacologically acceptable solvent in common with hydrophilic materials taken among the group consisting of water-soluble polymers, water-swelling polymers, sugar alcohols and salts followed by granulation in fluidized layer, granulation by stirring at high rate, drying by spraying and process for coat applying for granulation of amorphous nateglynide; 2) by mixing nateglynide crystals with hydrophilic materials taken among the group of water-soluble polymers, water-swelling polymers, sugar alcohols and salts and the following application of the high shift force to the prepared mixture; 3) by mixing nateglynide crystals with hydrophilic materials taken among the group of water-soluble polymers, water-swelling polymers, sugar alcohols and salts and the following plasticizing the prepared mixture in melt by heating and milling at cooling; 4) by dissolving nateglynide crystals in pharmacologically acceptable liquid additives wherein liquid additives represent water-soluble polymers that are liquid at 37°C. Using amorphous nateglynide allows preparing the nateglynide preparation with immediate release wherein the dissolving rate of medicinal agents is high and without crystalline transition during preparing or preserving preparations.
EFFECT: valuable pharmaceutical properties of preparation.
6 cl, 3 tbl, 9 dwg
FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes using xenogenous oligo-and/or polyribonucleotides, namely total RNA and tRNA, as an active component of external anhydrous medicinal agent for a single treatment of skin tumor relapse (for example, basalioma) or infections caused by herpes virus and the corresponding method for treatment. The claimed external anhydrous medicinal agents decline effectively relapses of indicated diseases after a single intake.
EFFECT: enhanced effectiveness and valuable medicinal properties of agents.
5 cl, 2 ex
FIELD: veterinary science.
SUBSTANCE: the suggested preparation contains dense propolis, vegetable oil, extract out of dead bees based upon glycerol, lanolin, honeycombs' cutting off, moreover, all the components should be taken at certain quantitative ratio, weight%: honeycombs' cutting off 15-20, dense propolis 20-25, extract out of dead bees upon glycerol 7.5 -10, lanolin 20-25, vegetable oil - the rest, moreover, honeycombs' cutting off includes honey residues. The preparation in question is of high biological activity, provides shortened terms for recovery in animals and excludes allergic reactions.
EFFECT: higher efficiency for therapy.
1 cl, 8 ex
FIELD: medicine, phytotherapy, infectious diseases, pharmaceutical industry.
SUBSTANCE: invention relates to a method for preparing ointment used in erysipelas treatment. Method for preparing ointment used in erysipelas treatment involves milling washed and dried viper's-bugloss roots (Echium rubrum, Jacg, family Boraginaceae) and their extraction with melted butter under the definite conditions. Then extract is infused at stirring for a definite time, macerate is filtered off at cooling to a definite temperature and poured off. Extraction is carried out twice, vegetable raw residues are squeezed out, and prepared sap is combined with first two extracts, settled for a definite time and bottled. Method provides preparing ointment that promotes to effective treatment of erysipelas and reducing treatment period.
EFFECT: improved preparing method, valuable medicinal properties of ointment.
FIELD: medicine, oncology.
SUBSTANCE: one should intravenously irradiate blood with low-energy He-Ne laser including recanalization and venous catheterization at installing a quartz light guide into venous lumen through the catheter. At initial stage of surgical therapy on should introduce a light guide into the lumen of V.portae to irradiate blood in the basin of portal circulation during the main stages of operation conducted. Before operation, one should intramuscularly inject halavit at the dosage of 100 mg. The innovation enables to increase efficiency of laser therapy due to affecting "a target organ" directly, that is a liver, with photomodified blood with the purpose to achieve antimutagenic and antimetastatic effect, normalize the processes of antioxidant protection, stimulate the mechanisms of anti-cancer immunity and improve local microcirculation.
EFFECT: higher efficiency of prophylaxis.