Enterosorbent for heavy metal excretion

FIELD: medicine, food processing industry.

SUBSTANCE: claimed enterosorbent contains 45-80 mass % of polysaccharide and balance: boehmite. As polysaccharide enterosorbent contains chitosan or lignin, or microcrystalline cellulose. Enterosorbent of present invention is useful in excretion of toxic substances from organism, prophylaxis of heavy metal intoxication, etc.

EFFECT: enterosorbent with high adsorption ability in relation to heavy metal ions; application only one kind of polysaccharide.

2 cl, 1 ex, 3 tbl, 2 dwg


The invention relates to medicine, food industry (biologically active additives) and is intended for the excretion of toxic substances, to prevent poisoning and heavy metal ions, etc.

Known composite enterosorbent (RF patent for application No. 2002120546, IPC 7 a 61 K 35/78, publ. 20.03.2004,) containing a powder mix of the six components in the following ratio, wt.%:

Lignin hydrolysis25,0-35,0
Microcristalina cellulose (CMC)25,0-35,0
Highly dispersed silicon dioxide25,0-35,0
Calcium or magnesium stearate0,5-1,0

The main disadvantage of composite enterosorbent is low adsorption ability with respect to cations (60%) and anions (32%) heavy metals (as follows from the following table 2). In addition, it includes four types of polysaccharides in a predetermined quantitative ratio that causes the need to purchase every one of them and use when obtaining enterosorbent in the required quantity of each.

The closest to the proposed solution I have is chosen for the prototype gel solution of chitosan (RF patent No. 2175234, IPC 7 And 61 To 35/56, publ. 27.10.2001, prepared in 1%acetic acid solution used in the method of removal of lead and Nickel from the body of animals.

The main disadvantage of the known solutions is the low adsorption capacity with respect to heavy metals. For example, experiments have shown that gel solution of chitosan reduces the amount of chromate ion (CrO42-) in a solution of 88%, i.e. below the proposed enterosorbent 12%.

The main technical result of the proposed invention is a high adsorption capacity towards heavy metal ions to 100% (table 2 and 3). In addition, for preparation of the enterosorbent is sufficient to use only one kind of polysaccharide.

This technical result is achieved by the fact that the enterosorbent containing polysaccharide, according to the proposed solution further comprises boehmite in the following ratio, wt.%:


In addition, as of polysaccharide proposed enterosorbent contains chitosan, or lignin, or microcrystalline cellulose.

Conducted by the applicant's analysis of the level of technology allowed the install the analogs characterized by the sets of characteristics is identical for all features of the proposed enterosorbent, no. Therefore, the claimed invention meets the condition of patentability "novelty".

Search results known solutions in this and related fields in order to identify characteristics that match the distinctive features of the prototype of the claimed invention, have shown that they do not follow explicitly from the prior art.

Of certain of applicant's prior art there have been no known effect provided essential features of the invention transformations on the achievement of the technical result. Therefore, the invention meets the condition of patentability "inventive step".

An example of a specific implementation.

Days of receipt of the application of the enteric 1.5 g of polysaccharide, namely lignin in the form of the drug polifan (Polyphepanum) produced by LLC "ecosphere", , Veliky Novgorod, R/1211/3 soaked in 400 ml of water for 3.5 hours for the formation of gel solution. A drop of the solution was investigated using electron transmission microscope JEM 100 CXII (Japan). Electronic photography is shown in figure 1. Boehmite was obtained by interaction of aluminium powder with water in a slightly alkaline environment. To do this, to the resulting gel solution was added 0.45 g Alu is enyioha powder (GOST 5494-95) and 2 ml of concentrated solution of NH 4OH to create an alkaline environment. The resulting mixture was heated to 50°and left until the completion of the reaction of aluminum powder with water. Then the mixture was filtered on a Buechner funnel using a water-jet pump, washed to a neutral pH. Sediment enterosorbent were dried at 50-75°and then sterilized in an oven at 160°C for 1 hour. Received enterosorbent also examined with an electron microscope. E-the photograph presented in figure 2. From a comparison of figures 1 and 2 shows that in the claimed enterosorbent fiber polysaccharide (lignin) is covered with fine crystalline particles of boehmite. The study of x-ray phase composition of the sample obtained enterosorbent conducted on the device DRON-2 using R-copper radiation with a wavelength of 1,54178 and Nickel-beta filter. Ray diffractometer sample characteristics are shown in table 1, from which it follows that as the crystalline phase sample contains boehmite. Admixtures of other crystalline phases were not detected.

Table 1
no diffraction linesThe experimental value of interplanar distances dexp.that ÅThe reference value of interplanar distances dRef., (ASTM#21-1307 Å
for AlOOH (boehmite)
5at 1,865to 1.86

Similarly got enterosorbent when used as polysaccharide microcrystalline cellulose (microcrystalline Cellulose, powder, case, number Chem. Abstr. 9004-34-6) or chitosan (Chitosan from crab shells, the register number in Chem. Abstr. 9012-76-4).

Test samples of enterosorbent on adsorption capacity towards heavy metal ions Cd2+, Cu2+, CrO42-was carried out as follows. A portion of 0.10 g of the enteric containing polysaccharide and boehmite, poured 10 ml of bidistilled water. Then was added dropwise a solution of hydrochloric acid to pH=5,5, after which the resulting solution was injected into a solution of metal salt to a concentration of 10 mg/l (10 PPM). The solution was stirred with a glass rod and left for 4 hours. Then it was filtered through the filter of "blue ribbon" and perform the determination of heavy metals by Stripping voltammetry method. Cations were determined by mercury captured cnom electrode with a silver substrate. The chromate anion was determined by graphite working electrode. The reference electrode - chloro-silver in 1 M KCl. The electrochemical cell is a quartz glass with a capacity of 15 ml of Removing dissolved oxygen was performed by UV-radiation of a mercury quartz lamp, built-in analyzer, according to the method proposed in [Aaaaaaa, Gmorozov, Vinmoldova, Vonsiatsky //journal of the analyte. chemistry. - 1983. - v.38, 9. - s-1586], on the background of 0.5 M formic acid. Voltammetric curves were recorded on the analyzer type STA-1 (manufacturer firm ITM, , Tomsk, Russia), combined with a computer. Estimation of concentration of ions was performed additives.

Data on the sorption capacity of the samples of the claimed enterosorbent containing polysaccharide and boehmite, as well as analog and prototype are given in table 2.

Table 2
No. sampleDescriptionpercent sorption of heavy metal ions
5The placeholder42,071,588,0

In the samples of the claimed enterosorbent the ratio of the components was as follows: in the first sample, the lignin content of 60%, boehmite - 40%; in the second sample, the content of chitosan 60%, boehmite - 40%; in the third sample the MCC content 45%, boehmite - 55%.

To determine the optimal ratio of boehmite and polysaccharide samples were made of enterosorbent containing chitosan and boehmite at different ratio of components, and determined the percentage sorption of heavy metal ions Cd2+, Cu2+, CrO42-. Data on the sorption capacity of these samples are shown in table 3.

Table 3
No. sampleThe content of chitosan, wt.%The content of boehmite, wt.%percent sorption of heavy metal ions
19010 90,210088,0
53565of 87.010093,0

As can be seen from table 3, the best sorption characteristics with respect to the ions of heavy metals has enterosorbent containing chitosan and boehmite in a ratio of components: chitosan - 45-80%, boehmite - 55-20%. When the content of the enterosorbent boehmite less than 20% and more than 55%, a deterioration of the sorption properties.

Similar results percentage obtained by using as lignin polysaccharide or MCC.

For the proposed enterosorbent after numerous tests as polysaccharides chitosan and lignin selected as providing the best sorption characteristics, and MCC as a relatively cheap and widespread substance.

As can be seen from table 2 and 3, the inventive enterosorbent better absorbs heavy metal ions compared with prototype: cations in 13-30%, anions - 7-12%.

It should be noted that savla is my substance meets the requirements requirements chelators, which are described, for example, in the work (Enterosorption /edited Naalehu. - L., 1991. - 336 S.).

We also received positive results from absorption of the claimed enterosorbent of serum such toxic substances as conjugatively bilirubin and creatinine.

1. Enterosorbent for the removal of heavy metals containing polysaccharide, characterized in that it further comprises boehmite in the following ratio, wt.%:


2. Enterosorbent according to claim 1, characterized in that it contains polysaccharide chitosan, or lignin, or microcrystalline cellulose.


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