Enterosorbent for heavy metal excretion
FIELD: medicine, food processing industry.
SUBSTANCE: claimed enterosorbent contains 45-80 mass % of polysaccharide and balance: boehmite. As polysaccharide enterosorbent contains chitosan or lignin, or microcrystalline cellulose. Enterosorbent of present invention is useful in excretion of toxic substances from organism, prophylaxis of heavy metal intoxication, etc.
EFFECT: enterosorbent with high adsorption ability in relation to heavy metal ions; application only one kind of polysaccharide.
2 cl, 1 ex, 3 tbl, 2 dwg
The invention relates to medicine, food industry (biologically active additives) and is intended for the excretion of toxic substances, to prevent poisoning and heavy metal ions, etc.
Known composite enterosorbent (RF patent for application No. 2002120546, IPC 7 a 61 K 35/78, publ. 20.03.2004,) containing a powder mix of the six components in the following ratio, wt.%:
|Microcristalina cellulose (CMC)||25,0-35,0|
|Highly dispersed silicon dioxide||25,0-35,0|
|Calcium or magnesium stearate||0,5-1,0|
The main disadvantage of composite enterosorbent is low adsorption ability with respect to cations (60%) and anions (32%) heavy metals (as follows from the following table 2). In addition, it includes four types of polysaccharides in a predetermined quantitative ratio that causes the need to purchase every one of them and use when obtaining enterosorbent in the required quantity of each.
The closest to the proposed solution I have is chosen for the prototype gel solution of chitosan (RF patent No. 2175234, IPC 7 And 61 To 35/56, publ. 27.10.2001, prepared in 1%acetic acid solution used in the method of removal of lead and Nickel from the body of animals.
The main disadvantage of the known solutions is the low adsorption capacity with respect to heavy metals. For example, experiments have shown that gel solution of chitosan reduces the amount of chromate ion (CrO4 2-) in a solution of 88%, i.e. below the proposed enterosorbent 12%.
The main technical result of the proposed invention is a high adsorption capacity towards heavy metal ions to 100% (table 2 and 3). In addition, for preparation of the enterosorbent is sufficient to use only one kind of polysaccharide.
This technical result is achieved by the fact that the enterosorbent containing polysaccharide, according to the proposed solution further comprises boehmite in the following ratio, wt.%:
In addition, as of polysaccharide proposed enterosorbent contains chitosan, or lignin, or microcrystalline cellulose.
Conducted by the applicant's analysis of the level of technology allowed the install the analogs characterized by the sets of characteristics is identical for all features of the proposed enterosorbent, no. Therefore, the claimed invention meets the condition of patentability "novelty".
Search results known solutions in this and related fields in order to identify characteristics that match the distinctive features of the prototype of the claimed invention, have shown that they do not follow explicitly from the prior art.
Of certain of applicant's prior art there have been no known effect provided essential features of the invention transformations on the achievement of the technical result. Therefore, the invention meets the condition of patentability "inventive step".
An example of a specific implementation.
Days of receipt of the application of the enteric 1.5 g of polysaccharide, namely lignin in the form of the drug polifan (Polyphepanum) produced by LLC "ecosphere", , Veliky Novgorod, R/1211/3 soaked in 400 ml of water for 3.5 hours for the formation of gel solution. A drop of the solution was investigated using electron transmission microscope JEM 100 CXII (Japan). Electronic photography is shown in figure 1. Boehmite was obtained by interaction of aluminium powder with water in a slightly alkaline environment. To do this, to the resulting gel solution was added 0.45 g Alu is enyioha powder (GOST 5494-95) and 2 ml of concentrated solution of NH 4OH to create an alkaline environment. The resulting mixture was heated to 50°and left until the completion of the reaction of aluminum powder with water. Then the mixture was filtered on a Buechner funnel using a water-jet pump, washed to a neutral pH. Sediment enterosorbent were dried at 50-75°and then sterilized in an oven at 160°C for 1 hour. Received enterosorbent also examined with an electron microscope. E-the photograph presented in figure 2. From a comparison of figures 1 and 2 shows that in the claimed enterosorbent fiber polysaccharide (lignin) is covered with fine crystalline particles of boehmite. The study of x-ray phase composition of the sample obtained enterosorbent conducted on the device DRON-2 using R-copper radiation with a wavelength of 1,54178 and Nickel-beta filter. Ray diffractometer sample characteristics are shown in table 1, from which it follows that as the crystalline phase sample contains boehmite. Admixtures of other crystalline phases were not detected.
|no diffraction lines||The experimental value of interplanar distances dexp.that Å||The reference value of interplanar distances dRef., (ASTM#21-1307 Å|
|for AlOOH (boehmite)|
|5||at 1,865||to 1.86|
Similarly got enterosorbent when used as polysaccharide microcrystalline cellulose (microcrystalline Cellulose, powder, case, number Chem. Abstr. 9004-34-6) or chitosan (Chitosan from crab shells, the register number in Chem. Abstr. 9012-76-4).
Test samples of enterosorbent on adsorption capacity towards heavy metal ions Cd2+, Cu2+, CrO4 2-was carried out as follows. A portion of 0.10 g of the enteric containing polysaccharide and boehmite, poured 10 ml of bidistilled water. Then was added dropwise a solution of hydrochloric acid to pH=5,5, after which the resulting solution was injected into a solution of metal salt to a concentration of 10 mg/l (10 PPM). The solution was stirred with a glass rod and left for 4 hours. Then it was filtered through the filter of "blue ribbon" and perform the determination of heavy metals by Stripping voltammetry method. Cations were determined by mercury captured cnom electrode with a silver substrate. The chromate anion was determined by graphite working electrode. The reference electrode - chloro-silver in 1 M KCl. The electrochemical cell is a quartz glass with a capacity of 15 ml of Removing dissolved oxygen was performed by UV-radiation of a mercury quartz lamp, built-in analyzer, according to the method proposed in [Aaaaaaa, Gmorozov, Vinmoldova, Vonsiatsky //journal of the analyte. chemistry. - 1983. - v.38, 9. - s-1586], on the background of 0.5 M formic acid. Voltammetric curves were recorded on the analyzer type STA-1 (manufacturer firm ITM, , Tomsk, Russia), combined with a computer. Estimation of concentration of ions was performed additives.
Data on the sorption capacity of the samples of the claimed enterosorbent containing polysaccharide and boehmite, as well as analog and prototype are given in table 2.
|No. sample||Description||percent sorption of heavy metal ions|
In the samples of the claimed enterosorbent the ratio of the components was as follows: in the first sample, the lignin content of 60%, boehmite - 40%; in the second sample, the content of chitosan 60%, boehmite - 40%; in the third sample the MCC content 45%, boehmite - 55%.
To determine the optimal ratio of boehmite and polysaccharide samples were made of enterosorbent containing chitosan and boehmite at different ratio of components, and determined the percentage sorption of heavy metal ions Cd2+, Cu2+, CrO4 2-. Data on the sorption capacity of these samples are shown in table 3.
|No. sample||The content of chitosan, wt.%||The content of boehmite, wt.%||percent sorption of heavy metal ions|
As can be seen from table 3, the best sorption characteristics with respect to the ions of heavy metals has enterosorbent containing chitosan and boehmite in a ratio of components: chitosan - 45-80%, boehmite - 55-20%. When the content of the enterosorbent boehmite less than 20% and more than 55%, a deterioration of the sorption properties.
Similar results percentage obtained by using as lignin polysaccharide or MCC.
For the proposed enterosorbent after numerous tests as polysaccharides chitosan and lignin selected as providing the best sorption characteristics, and MCC as a relatively cheap and widespread substance.
As can be seen from table 2 and 3, the inventive enterosorbent better absorbs heavy metal ions compared with prototype: cations in 13-30%, anions - 7-12%.
It should be noted that savla is my substance meets the requirements requirements chelators, which are described, for example, in the work (Enterosorption /edited Naalehu. - L., 1991. - 336 S.).
We also received positive results from absorption of the claimed enterosorbent of serum such toxic substances as conjugatively bilirubin and creatinine.
1. Enterosorbent for the removal of heavy metals containing polysaccharide, characterized in that it further comprises boehmite in the following ratio, wt.%:
2. Enterosorbent according to claim 1, characterized in that it contains polysaccharide chitosan, or lignin, or microcrystalline cellulose.
SUBSTANCE: claimed method includes blending of active base and auxiliary ingredients to form tablet corn, representing composition of sugar powder, monocrystalline cellulose, vinylpyrrolidone and calcium stearate; humidifying of obtained mixture; drying of obtained granules; dry granulation through granulator with standardized holes; pelletization of standardized granules to produce tablet corn; and coating. Mixture is humidified with 5-7 % starch mucilage in starch mucilage/humidifying mixture mass ratio of 1:25-30, wherein mixture is blending with starch mucilage for homogeneous distribution wet in whole mass.
EFFECT: tablets with increased hardness and enhanced pharmacological activity.
2 cl, 2 ex
FIELD: medicine, in particular veterinary.
SUBSTANCE: invention relates to method for treatment of cattle intoxicated with Cynoglossum officinalis containing in feed hey as admixture. Claimed method includes administration perorally of sorbent, namely healthy feed supplement containing in dose of aluminum silicate in dose of 0.15 g/kg of body mass; saccharose in dose of 0.5-1.0 g/kg of body mass; and beta-carotene comprising 10-20 mg/ml of active ingredient in dose of 2 ml 1 time per day; administration intramuscularly of 1 % riboflavin mononucleotide solution 3 ml; 1 % pyridoxine hydrochloride solution 1 time per day; tetravit in dose of 3 ml 2 time during treatment course with interval for 5 days, wherein total treatment course includes 10 days.
EFFECT: method with simultaneous antioxidant, antitoxic, metabolism stimulating, and liver function normalizing action.
2 ex, 3 tbl
FIELD: experimental medicine.
SUBSTANCE: in rabbits one should induce hepatic ischemia due to occlusion of hepato-duodenal ligament for 30 min. Moreover, reamberin should be introduced at the dosage of 35 ml/kg during the whole period of occlusion, and at the dosage of 5 ml/kg for 10 min after removing the above-mentioned occlusion. The method provides preventing the death of experimental animals in case of ischemic exposure being harmful for this type of animals.
EFFECT: higher efficiency of protection.
SUBSTANCE: invention relates to application of pectin solution as detergent for skin and hair in radioactive and environmentally hazardous regions. Pectin containing in solution due to chelating action bonds to heavy metal ions to form stable compounds (micelles) having very large size and prevents transferring thereof trough transdermal barrier. Formed micells may be easily removed from human body.
EFFECT: new detergent for skin and hair useful in radioactive and environmentally hazardous regions.
2 ex, 5 tbl
SUBSTANCE: the present innovation deals with decreasing and/or blocking adhesion of pathogenic substances and organisms upon eucaryotic cells. The preparation suggested contains, at least, one carbohydrate at structural link of uronic acid at one of its ends. About 10 to 100% available terminal structural links of uronic acids of carbohydrates contain, moreover, a double bond which, in particular, is available between C4- and C5-atoms. The innovation broadens the number of antipathogenic means for eucaryotic cells.
EFFECT: higher efficiency.
17 cl, 13 ex, 1 tbl
FIELD: veterinary science.
SUBSTANCE: the suggested composition contains a certain salt of calcium hypochlorite as an oxidizing agent and, additionally, zeolite as an adsorbent at the following ratio of components, weight%: a certain salt of calcium hypochlorite 30.0-70.0, zeolite - the rest. Application of the composition suggested provides neutralization of animal skin under any environmental conditions, both at plus and minus environmental temperature values.
EFFECT: higher efficiency of application.
6 ex, 1 tbl
FIELD: herb therapy.
SUBSTANCE: method comprises laboratory analysis of human body fluids, reveal of excess/deficit of macro and trace minerals followed by selection of appropriate drugs. In case of excess of macro and trace minerals, herb gatherings favoring neutralization and excretion of excess trace minerals and antagonists with maximum concentration of the latter are used. In case of deficit of macro and trace minerals in the human body, herb gatherings having elevated concentrations of such minerals and enhancing assimilation thereof with coefficients of biological accumulation above 1.0 are used. Herb gatherings are administered thrice a day 15-30 min before meal in the form of aqueous extract prepared in the basis of 10-30 g of dry vegetable stock per 150-300 ml water. Administration of herb gathering is combined with administration of vitamins activating biological transformation of antagonists or deficient macro or trace minerals in human body.
EFFECT: normalized trans mineral homeostasis due to high bioavailability and assimilability of developed herb complexes.
7 cl, 5 ex
SUBSTANCE: method involves applying traditional treatment and additionally administering 2 ml of 1% emoxipin solution electrophoresis to epigastric zone at acute stage end daily during 10 days.
EFFECT: accelerated inflammation relief and uterine mucous membrane recovery.
FIELD: medicine, veterinary science.
SUBSTANCE: it is suggested to apply indometophen known previously as a radioprotector. It has been established that application of indometophen at different terms within the first 4 d after irradiation helps to increase survival rate and affect positively the flow of reparative processes in the body at no side effects.
EFFECT: higher efficiency of therapy.
SUBSTANCE: the present innovation deals with obtaining biologically active substances of protein nature out of cereals, moreover it is necessary to isolate a stress separating protein 310 and/or protein being immunochemically similar to that as coarse and/or finely purified extract of the target product. For this purpose one should destruct cellular walls of 3-7-d-aged sprouts due to homogenization to isolate cell-free extract due to centrifuging which should be supplemented with a reagent-precipitator at the first stage under certain conditions to obtain residue followed by isolating a liquid phase which should be subjected to the second of impact with reagent-precipitator under certain conditions, then residue should be separated against a liquid phase due to centrifuging, and an obtained coarsely purified extract of target product should be separated against reagent-precipitator due to dialysis due to the impact of fine purification by gel filtration, if necessary. Moreover, one should conduct this procedure at certain temperature mode, and , if necessary, the extract of target product should be freeze dried. The suggested biologically active substance provides efficient regulation of body energy balance.
EFFECT: higher efficiency.
8 cl, 3 ex
SUBSTANCE: method involves covering gingival mucous membrane with screen substance like wax or photocurable Koferdamm before applying laser radiation treatment. Water or 30-35% aqueous hydrogen peroxide solution is sprayed over dental surface or bleaching gel diluted with hydrogen peroxide is applied. The dental surface is next exposed to continuous diode laser radiation with wavelength selected from bandwidth of 800-970 nm during 15-300 s. Laser radiation power density belongs to bandwidth of 10-100 W/cm2. Radiation energy dose is in the range of 40-3000 J with dose density being equal to 200-20000 J/cm2 diode laser power being equal to 2.8 W, light beam diameter being equal to 3.5-5 cm when being 1 to 2 mm far from the dental surface. When exposed to laser radiation, the dental surface is uniformly scanned with laser beam.
EFFECT: enhanced effectiveness and safety of the procedure.
6 cl, 4 tbl
SUBSTANCE: method involves studying intraocular fluid and determining total quantity of end products of nitrogen oxide metabolism (NO2/NO3). NO2/NO3 concentration in intraocular fluid being below 2 mg/l, disease clinical course development is predicted as favorable one (no ischemia signs being detected). NO2/NO3 concentration in intraocular fluid being equal to or greater than 2 mg/l, unfavorable clinical course is predicted (ischemia signs being available).
EFFECT: high accuracy of diagnosis.
FIELD: veterinary science.
SUBSTANCE: the present innovation deals with supplementing the feedstuff with mineral additive as neutralized white slime of alumina production of the following composition, weight%: aluminum oxide 25-35; silicon oxide 20-25; iron oxide 3-10; calcium oxide 3-10; sodium oxide 15-20; sulfur oxide 3-6; potassium oxide 0.5-2.0, free alkali, 0.02, not more; weight portion of moisture 15, not more, to be introduced once daily for about 5-7 d before transportation at the dosage of 200-300 g/animal/d. The innovation provides decreased level of stress and loses of meat productivity in cattle.
EFFECT: higher efficiency.
FIELD: medicine, pharmacology, pulmonology.
SUBSTANCE: pharmaceutical agent in form of aerosol in air mixture containing approximately 2.5-10 % of carbon dioxide gas is introduced into animal or human airways. Method of present invention provides drug delivery directly to damage area and drug concentration increasing in said area.
EFFECT: method with increased therapeutic effect at minimal drug doses.
24 cl, 13 dwg, 3 tbl, 27 ex
FIELD: medicine, dermatology.
SUBSTANCE: one should treat eruptive area with a gaseous flow of plasmochemical nitrogen oxide by replacing the flow along concentric trajectory against perifocal area towards ulcerous center, from the distance of 25 cm at the phase of exudative process 5 times weekly and from the distance of 15 cm during active proliferation thrice weekly at exposure time being 10 sec/sq.cm at the background of ciprolet, detralex, phencarol and aevit intake. The present innovation enables to decrease side effects due to deteriorating inflammatory processes, improving microcirculation, skin barrier function and regenerative processes.
EFFECT: higher efficiency of therapy.
FIELD: medicine, chemical-pharmaceutical industry.
SUBSTANCE: invention relates to a method for preparing curative emulsions that are used in hydropathy for aims of prophylaxis and therapy of different diseases. Method for preparing yellow turpentine emulsion for hydropathy involves heating and mechanical stirring castor oil, oleic acid, sodium hydroxide dissolved in water and galipot turpentine. Castor oil is used with color index 5 mg of iodine, not above, oleic acid with acid number 250 mg of KOH/g of acid, not less, and the content of oleic acid in mixture of unsaturated acids must be 77%, not less, and galipot turpentine with the content of dienes 60%, not less, and mixing all components is carried out under the definite conditions. Method provides preparing emulsion showing good colloidal stability and enhanced curative-prophylactic properties.
EFFECT: improved preparing method.
SUBSTANCE: remedy has alkaline metal hydroxide selected from group comprising potassium hydroxide, and/or sodium hydroxide, and/or calcium hydroxide and distilled water. Zinc compounds are additionally introduced under ingredients proportion, in % by mass: alkaline metal hydroxide 2-34; zinc compounds 0.01-1.2; distilled water the rest. Zinc oxide and/or zinc salt like ZnSO4 are selected as the zinc compounds. Stain solution is introduced into remedy composition, like 1-5% brilliant ethyl solution in alcohol in the amount of 0.1-0.5% by mass.
EFFECT: enhanced effectiveness of treatment; accelerated wound healing.
FIELD: veterinary science, pharmacotherapy.
SUBSTANCE: the present innovation deals with performing enterosorption by applying polysorb VP as a sorbent twice daily at the dosage of 100-300 mg/kg calf's body weight supplemented with potassium permanganate at concentration of 0.05-0.01% at the quantity of 500-600 ml. The innovation suggested enables to shorten duration of therapy.
EFFECT: higher efficiency of therapy.
3 ex, 4 tbl
FIELD: medicine, pharmacy.
SUBSTANCE: invention describes composition of a pressed tablet comprising multiple of hardened melted granules of nonsteroid anti-inflammatory preparation (NSAID) with a melting point in the range 30-300oC and comprising a loosening agent dispersed uniformly in it. Granules comprise a continuum phase of indicated nonsteroid anti-inflammatory preparation and the table composition comprises additionally silicon dioxide in the amount 0.05-5.0% of composition mass. Preferably, the composition comprises also a nongranulated component containing silicon dioxide and excipient. The preferable NSAID represents ibuprofen that has a melting point in the range 75-77oC. Method provides preparing tablet showing useful industrial properties and ability for dissolving.
EFFECT: improved preparing method, valuable pharmaceutical properties of agent.
34 cl, 16 tbl, 64 ex
FIELD: medicine, dermatology, pharmacy.
SUBSTANCE: invention proposes a cosmetic agent for prophylaxis of skin infectious diseases that comprises an active substance and a conducting agent - multilamellar liposomes additionally. As an active substance dioxydin is used in the amount 0.00001-0.02 wt.-% to the external agent mass. Method for prophylaxis of skin infectious diseases involves using a cosmetic agent in the form of spoon or shampoo, or gel, or cream in the dose depending on selection of the composition and properties of cosmetic agent. Applying the agent results to reducing injurious effect on skin normal microflora, reducing danger from penetration of preparation in blood and providing high protection of skin against all species of infection. Invention can be used for prophylaxis of skin diseases in humans.
EFFECT: valuable medicinal properties of agent.
2 cl, 2 ex
FIELD: medicine, pharmaceutical industry, phytotherapy.
SUBSTANCE: invention proposes an agent used in treatment of infectious diseases. Agent used in treatment of infectious diseases comprises chitosan of polyfraction composition with amine groups of molecular mass from monomeric link - glucosamine to ˜350 kDa and deacetylation degree from ˜68 to ≤ 95% and vegetable raw aqueous extract chosen from the following group: Cetraria thallus, sage official herb, cocklebur leaves, black poplar buds, common wormwood herb, red roots, burdock roots, French honey-suckle herb, bur-marigold tripartite herb, sandy common immortelle flowers, dropwort elm-leaved flowers, river avens (Geum) roots, licorice glabrous roots, swampy sweet flag roots, burnet official roots,, nettle dioecious herb, swampy cudweed herb, common milfoil herb, sweet clover official herb, gum-free leaves, dropwort, willow bark, birch leaves, bilberry leaves, willow-herb narrow-leaves herb, peppermint herb, fenestrate Saint-John's-wort herb, knot-grass herb, shepherd's purse herb, violet pensy tricolor herb, speedwell herb, pot-marigold flowers, common tansy flowers, matricary official flowers, chicory roots, dandelion official roots, tormentil roots, cinnamon wild rose fruits, viburnum leaves, pinnate kalanchoe and maize stigmas. Aqueous extract is prepared by extraction of vegetable raw with demineralized water under definite conditions. Agent promotes to effective treatment of infectious diseases, such as chlamydiosis, herpes, erysipelas, viral hepatitis A and B, gastroenteric tract diseases, acute enteric infectious, and to declining period of clinical symptoms of diseases said.
EFFECT: valuable medicinal properties of agent.
10 cl, 2 dwg, 12 ex