Method for acne treatment

FIELD: medicine, in particular cosmetology, acne treatment.

SUBSTANCE: method includes multiple administration of isotretinoin in single dose of 0.1-0.3 mg/kg per day followed by dose increasing wherein total dose is 10-40 mg/kg with simultaneous chemical piling and cosmetic clearing.

EFFECT: effective treatment using decreased preparation doses and reduced side effects.

3 ex, 1 tbl, 2 cl

 

The invention relates to medicines for the treatment of dermatological diseases, in particular to protivougrevoe tools.

We already know that acne is a common disease that leads to the formation of irreversible defects of the skin (scars, pigmentation disorders, enlarged pores and capillaries) and impairment of psychosocial adaptation up to suicide attempts, and current treatments are often given serious adverse reactions and have little influence on the effects of the disease, which requires a long and costly correction.

There is a method of treating acne by prolonged use of antibiotics (Parsad D, Pandhi R, Nagpal R, Negi KS. Azithromycin monthly pulse vs daily doxycycline in the treatment of acne vulgaris. // J Dermatol. - 2001. - Jan. - Vol.28. - P.1-4).

Another known method of treatment of acne is the use of anti-androgens (Carmina E, Lobo RA. A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. // Clin Endocrinol (Oxf). - 2002. - Aug. - Vol.57. - P.231-234).

The closest analogue to the claimed method is a known method of acne treatment, including therapy by repeated ingestion doses of the drug containing retinoids (Nazmutdinov D.K. Treatment of patients vulgar eels by dharmaratnam containing 13-CIS-retinoic acid, based on the status of lipid peroxidation whether the Idov and sex hormones. The dissertation. Russian state medical University, cipher spec STI 14.00.11, M. 1995).

However, the implementation of this method have strong side effects in reactions of deterioration, dryness and peeling of skin, heylita, dermatitis, nasal bleeding, joint pain, depression, changes in clinical and biochemical blood tests, and irreversible skin changes persist after treatment.

The technical result, which can be obtained by carrying out the invention, is to prevent scarring, age spots, shrinking pores and capillaries in the alignment of existing scars, to accelerate the receipt of stable clinical outcome and to reduce side effects.

This result is achieved by a method for the treatment of acne, including therapy by repeated ingestion doses of the drug containing retinoids, due to the fact that during the time of ingestion doses of the drug containing retinoids, repeatedly perform chemical peels and cosmetic cleaning, as a retinoid used isotretinoin, and occasional doses of isotretinoin is prescribed at the rate of 0.1-0.3 mg/kg per day, followed by lower doses in exchange dose of 10-40 mg/kg

And also due to the fact that the ingestion doses pre is Arata, contains retinoids, exercise daily and dose rate, less featured 3-10 times.

And also due to the fact that chemical peels and cosmetic cleaning is carried out in an amount of from 4 to 15 procedures with the use of alpha beta retinol skin of foliator and the evacuation of the ducts of the sebaceous glands, pustules, and cysts is carried out in a period of time of ingestion doses of the drug containing retinoids.

The implementation of the inventive method is illustrated by the following examples of its application.

Example 1.

Patient L., 18 years old, came with complaints of widespread rash on the face and trunk. Ill for 6 years, had received antibiotic treatment and drying means without effect. Complaints from internal organs is not really indicators of clinical blood and urine analysis, biochemical blood analysis without pathological changes. Heredity: the mother oily seborrhea and acne, enlarged pores, small atrophic scars. Allergic reactions denies. Infectious diseases sick 2-3 times a year.

The objective at the time of initial inspection: on the face, neck, chest, shoulders multiple comedones, papules and pustules with a diameter up to 7 mm merging among themselves with the formation of fistulous passages, clicking on the items highlighted abundant purulent hemorrhagic content is mine. Throughout the affected skin surface stains bluish-purple color, atrophic scars, enlarged pores.

Treatment

Inside: isotretinoin at a dose of 0.3 mg/kg / day for 8 weeks, then gradually decrease the dose to 0.1 mg/kg for 12 weeks. Heading dose was 30 mg/kg;

externally: at the time of ingestion doses of isotretinoin treatments include chemical peels and cosmetic cleaning of affected areas of the skin Ichthyol soap, warm up by rubbing lotion "Knox" (Holy Land cosmetics laboratories, Israel, hygienic certificate No. P), peeling alpha beta retinol skin-foliation (Holy Land cosmetics laboratories, Israel, hygienic certificate No. P) for 20 min, the softening of the elements of the solution "And Knox solution" (the same), the evacuation of the contents of the ducts of the sebaceous glands, pustules and cysts, application of anti-inflammatory the mask 20 min, application of restorative cream "alpha beta retinol restoringa cream" (Holy Land cosmetics laboratories, Israel, hygienic certificate No. P) and antiseptic powder "Double action" (Holy Land cosmetics laboratories, Israel, hygienic certificate No. P).

During the first 12 weeks of treatment procedures were performed 1 time per 2 weeks, then 1 every 4 weeks. Just Petropoulos procedures.

Of the side effects during the first two months were marked by dryness and peeling of the skin, which is easily corrected by applying moisturizers and decreased after dose reduction.

The improvement of the skin appeared 4 weeks after the start of treatment, after 2 months. the number of lesions decreased by more than 50%, clinical recovery was achieved after 6 months. As a result of external therapy has OSVETLENIE spots, reduced pores, significantly decreased the depth of the scars. Follow-up within 3 years of relapse is not found.

Example 2.

Patient K., 16 years old, came with complaints of a rash on the face, chest, back. Ill for 4 years. Received isotretinoin in standard dosage of 1 mg/kg of body weight within 3 months. Noted a slight improvement in the form of a flattening of inflammatory cells, while troubled severe dryness, thinning, bleeding of the skin and mucous membranes, inflammation of the red portion of the lips. Examination: on the face of multiple nodular cystic elements with abundant purulent hemorrhagic content, merging among themselves, atrophic scars bluish-purple color. The skin is very thin, easily damaged and bleeding on palpation. The red border of the lips hyperemic, edematous, with flaking on the surface, in the corners of the mouth of the crack. On to the same chest and back multiple papules bright red color with a diameter of 0.7 mm, stains bluish color, scars. The patient psychologically depressed, gratefully.

Treatment

Inside: dose isotretinoin - 0.3 mg/kg / day for 4 weeks, then 0.1 mg/kg / day for 3 months. Dose rate was 17 mg/kg;

outer: performed procedure described in example 1 sequences with a frequency of 2 times per week for 2 weeks, then 1 time per week during the month, then 1 every 3-4 weeks for 3 months.

To achieve a state of clinical remission took 12 procedures.

Treatment results: a significant improvement in the form of resorption of inflammatory cells, reduce the amount of fresh papules was achieved 2 weeks after the start of combination therapy. In addition, significantly OSVETLENIE postinflammatory spots and smoother skin texture. Patient contact, notes the improvement in mood. Side effects of isotretinoin did not bother after reducing the daily dose.

Example 3.

Patient B., 28 years old, came with complaints of a recurring rash on face and neck, enlarged pores and the formation of unsightly scars. Suffering from acne for 15 years. Received treatment with antibiotics, anti-androgens to little effect. Complaints from internal organs does not show. Objectively: the skin of the face and neck fat is Aya, pronounced hyperkeratosis, enlarged pores, skin tone, the severity of skin folds do not correspond to the age. In the area of the nasolabial folds, cheeks, neck multiple papules and knots with a diameter up to 1 cm, bluish-purple in color, atrophic scars with a diameter of 5 mm and a depth of 2 mm.

Treatment: inside dose isotretinoin at a dose of 0.1 mg/kg of body weight for 4 months. in combination with external procedures described in example 1 sequences with a frequency of 1 every 2 weeks. Heading dose of isotretinoin was 10 mg/kg To achieve clinical recovery took 8 procedures.

Treatment results: a Significant improvement of the skin was observed already after 4 weeks after the beginning of the comprehensive treatment. In addition to clinical recovery was achieved alignment of the relief of the skin, improve its tone, shrinking pores, lighten spots. The patient noted significant improvement in emotional state. Follow-up within 2 years of relapse is not found.

Thus, the application of the proposed method of treatment can quickly achieve clinical improvement and cure without significant side effects, while preventing the formation of scars and correcting existing defects of the skin that reduces the total cost of disease treatment and correction of its consequences.

The method was verified at the Department of skin and venereal diseases qualification development Department, Russian state medical University, ARCS No. 19, Moscow, LLC "Center for aesthetic medicine" at a considerable number of patients, the results of which are presented in the table.

Table

The results of the treatment
The severity of acneModerateHeavyVery heavy
The result of the treatment
Remission49419
Significant improvement876
Only120

As can be seen from the table, the proposed method was applied in 120 patients with acne moderate, severe and very severe. The clinical cure rate and a significant improvement was achieved in 83% and 17% of patients, respectively, alignment, elevation, color, and texture of the skin was noted in all patients, indicating a high clinical efficiency of the method.

The proposed method is the method of choice in the treatment of acne severe and moderate flow, accompanied by the formation of defects of the skin.

How practically is checked, the basics of the n safe drugs and can be applied directly in this description.

1. Method of acne treatment, including therapy by repeated ingestion doses of the drug containing retinoids, characterized in that period of time of ingestion doses of the drug containing retinoids, repeatedly perform chemical peels and cosmetic cleaning, as a retinoid used isotretinoin, and occasional doses of isotretinoin is prescribed at the rate of 0.1-0.3 mg/kg per day, followed by lower doses in exchange dose of 10-40 mg/kg

2. The method according to claim 1, characterized in that chemical peels and cosmetic cleaning in the amount of from 4 to 15 procedures with the use of alpha beta retinol skin of foliator and evacuation of the contents of the ducts of the sebaceous glands, pustules, and cysts is carried out in a period of time of ingestion doses that contain isotretinoin.



 

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