Method for predicting disorders of pulmonary capillary circulation in patients in case of pulmonary cancer

FIELD: medicine, functional diagnostics.

SUBSTANCE: one should study microcirculatory route of ocular conjunctiva due to videobiomicroscopy. Moreover, one should calculate the size of varicosis of post-capillary venules, the area of capillary glomerules, amplitude and the length of microvessel's coiled section, amplitude and frequency coefficients, the size of postcapillary venule, the size of intravascular conglomerate of sludged erythrocytes, the coefficient of correlation between sludging and the degree of sludge-phenomenon. Depending upon the values of the above-mentioned parameters one should diagnose initial disorders of pulmonary capillary circulation, moderate disorders of pulmonary capillary circulation or pronounced disorders of pulmonary capillary circulation. The innovation enables to diagnose affected circulation in patients in case of pulmonary cancer in pre-operational period and carry out corresponding medicinal therapy.

EFFECT: higher accuracy of diagnostics.

3 ex

 

The invention relates to medicine, namely to functional diagnostics, and can be used to diagnose disorders of capillary blood flow in the lungs of patients with lung cancer. Methods for diagnosing disorders of capillary blood flow in the lungs of patients with lung cancer are not described in literature.

The invention is aimed at solving problems: ability to diagnose disorders of capillary blood flow in the lungs is a non-invasive method in vivo in patients with lung cancer.

The method consists in the use of videobeyonce conjunctiva of the eyes to diagnose disorders of capillary blood flow in the lungs of patients with lung cancer in vivo by calculating the size of the varicose extensions postcapillary venules (accuracy), square capillary glomeruli (Sto), amplitude (Aanda length of convoluted plot MicroSCADA (Dand); the calculation of the amplitude (Kand) and frequency (KD) factors; the size of the postcapillary venules (V), intravascular conglomerate legirovannykh erythrocytes (conglomerate), the coefficient of relatedness sladzhirovaniya (KSLand the sludge phenomenon. When this is diagnosed primary, moderate and severe violations of capillary blood flow in the lungs of patients with lung cancer. When the value of the size accuracy from 0 to 14.8 μm, Skfrom 0 to 7.2 μm, Andand from 65 to 85.1 μm, Dandfrom 158,1 to 226,1 μm Toandfrom 71 to 92,2 µm, KDfrom 28% to 38%, from 11.7 V to 16.3 microns, conglomerate from 20,5 to 35.3 μm ToSL≤0,1, sludge phenomenon ≤II degree diagnose primary violations of capillary blood flow in the lungs.

When the value of the size accuracy from 8 to 22.8 μm. Stofrom 65.2 to 95,4 μm Andandfrom 51,8 to 96.3 μm, Dandfrom 77 to is 165.8 μm Toandfrom 44.7 to 88,9 µm, KDfrom 12% to 64%, V is from 16,3 to 21.5 μm, conglomerate from 38,9 to 64,3 μm, 0,1 ≤SL≤ 0,7, sludge phenomenon ≤ III degree diagnose moderate violations of capillary blood flow in the lungs.

When the value of the size accuracy of 29 μm and more, Stofrom 63,5 μm or more, Andandfrom 92 to 120,8 μm, Dandfrom 150,9 to 232,1, Kandfrom 82,7 up of 116.7, KDfrom 10% to 14%, V 23,9 to 30.5 μm, conglomerate from 34,9 to 57.7 μm ToSL≥ 0.9, the sludge phenomenon ≥ III degree diagnose expressed human capillary blood flow in the lungs.

The method is as follows. The sitting patient are videobeyonce with making paintings microvasculature of the conjunctiva of the eye on the monitor of a personal computer with subsequent morphometric processing of the received video. When this is calculated: the size of the varicose extensions postcapillary venules (accuracy), the area of the capillary club the Cove (S k), amplitude (Aandand the length of convoluted plot MicroSCADA (Dand), amplitude (Kand) and frequency (KDfactors; the size of the postcapillary venules (V), intravascular conglomerate legirovannykh erythrocytes (conglomerate), the coefficient of relatedness sladzhirovaniya (KSL) and the degree of sludge phenomenon. The study conducted by slit lamp SL-ZG, equipped with video production JSC "Zagorsk optical-mechanical plant", gzegorek. GOST 12.2.025-76, TU - 3.2438-91.

The advantage of this method lies in the possibility of diagnostics of disorders of capillary blood flow in the lungs is a non-invasive method in vivo in patients with lung cancer.

Examples of specific performance:

Example 1. Patient T., 61. Diagnosis; squamous cell carcinoma moderately differentiated carcinoma proximal bronchus to the right, T2N0M0. If videobeyonce - size sacculate - 10.8 microns, Sk- 2.5 µm, Andand-79,2 μm, Dand- 159,5 μm Toand- 83 µm, KD- 32%, V of 12.4 μm, conglomerate - 29,7 μm. ToSL=0,1, sludge phenomenon of I degree. Was diagnosed with primary disorders of capillary blood flow in the lungs. Intraoperatively, the patient was performed lung biopsy in the zone free from tumor growth. Made histological preparations with coloring by Romanovsky and with hematoxylin-eosin and subsequent morphological studies the study. In the study of tissue specimens were identified: poor plethora of blood vessels, in a single vessel swelling of the walls, bronchial lymph histiocytoma infiltrates. Perivascular edema in places. Weak sludge erythrocytes. These symptoms are the initial signs of violation of capillary blood flow.

Example 2. Patient P., aged 65. Diagnosis: squamous cell usernotification cancer, upper lobe bronchus on the left, T2N0M0. If videobeyonce - size sacculate - 22,7 μm, Stoto 69.9 μm Andand- 66,9 μm, Dand- 84,2 μm Toand- 53,07 µm, KD- 42%, V of 19.8 μm, conglomerate - 39,6 μm ToSL= 0,33, sludge phenomenon of II degree. Was diagnosed with moderate violations of capillary blood flow in the lungs. Intraoperatively, the patient was performed lung biopsy in the zone free from tumor growth. Made histological preparations with coloring by Romanovsky and with hematoxylin-eosin and subsequent morphological study. In the study of tissue specimens were identified: vessels moderately full, tortuous, wall places thickened, swollen endothelium, perivascular edema. Moderate sludge erythrocytes. These symptoms are signs of moderate violations of capillary blood flow.

Example 3. Patient K., 54 years. Diagnosis: squamous cell carcinoma of usernotification the cancer proximal bronchus to the right with the transition to intermediate, T2N1M0. If videobeyonce - size sacculate -60,7 μm, Sk- 119,3 μm Andandfor 95.8 μm, Dand- of 182.2 μm Toand- 113 μm, KD- 12% V to 29.8 μm, the conglomerate to 46.7 μm. ToSL= 1, the sludge phenomenon of III degree. Diagnosed expressed human capillary blood flow in the lungs. Intraoperatively, the patient was performed lung biopsy in the zone free from tumor growth. Made histological preparations with coloring by Romanovsky and hematoxilin-eosin and subsequent morphological study. In the study of tissue specimens were identified: the sanguineous vessels, walls greatly thickened, edematous, swollen endothelium. Pronounced sludge of red blood cells, perivascular edema with focal lymphoid infiltration. These manifestations are clear signs of violations of the capillary blood flow.

The use of the proposed method to diagnose disorders pulmonary capillary blood flow in patients with lung cancer in cooperationon period and implement appropriate corrective medication.

Method for the diagnosis of disorders of capillary blood flow in the lungs of patients with lung cancer, including patient study microvasculature of the conjunctiva of the eye method videobeyonce with calculation of the size of the VA is ikosnym extensions postcapillary venules (accuracy), square capillary glomeruli (Sk), amplitude (Aanda length of convoluted plot MicroSCADA (Dand), the calculation of the amplitude (Kand) and frequency (KD) factors; the size of the postcapillary venules (V), intravascular conglomerate legirovannykh erythrocytes (conglomerate), the coefficient of relatedness sladzhirovaniya (KSLand the sludge phenomenon, and when the value of the size accuracy from 0 to 14.8 μm, Stofrom 0 to 7.2 μm, AI from 65 to 85.1 μm, Dandfrom 158,1 to 226,1 μm Toandfrom 71 to 92,2 µm, KDfrom 28% to 38%, from 11.7 V to 16.3 microns, conglomerate from 20,5 to 35.3 μm ToSL≤0,1, sludge phenomenon ≤ II degree diagnose primary violations of capillary blood flow in the lungs; when the value of the size accuracy from 8 to 22.8 μm, Stofrom 65.2 to 95,4 μm Andandfrom 51,8 to 96.3 μm, Dandfrom 77 to is 165.8 μm Toandfrom 44.7 to 88,9 μm ToDfrom 12% to 64%, V is from 16,3 to 21.5 μm, conglomerate from 38,9 to 64,3 μm, 0,1≤SL≤ 0,7, sludge phenomenon:≤ III degree diagnose moderate violations of capillary blood flow in the lungs; when the value of the size accuracy of 29 μm and more, Stofrom 63,5 μm or more, Andandfrom 92 to 120,8 μm, Dandfrom 150,9 to 232,1, Kandfrom 82,7 up of 116.7, KDfrom 10% to 14%, V 23,9 to 30.5 μm, conglomerate from 34,9 to 57.7 μm ToSL≥ 0.9, the sludge phenomenon ≥ III degree diagnostician who have expressed human capillary blood flow in the lungs.



 

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