Preparation "askokhol" for body mass correction in obesity

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of medicinal agents of vegetable origin used for lose weight and for constant maintenance of body optimal mass in obesity. Invention proposes using the preparation "Askokhol" for correction of body mass in obesity by its oral administration in the dose one tea spoon, 3 times per a day for 18 days. Clinical result after 3.5 year of the preparation using shows the possibility for maintenance of stable body mass for prolonged time being without any negative results.

EFFECT: enhanced effectiveness and valuable medicinal properties of agent.

3 tbl, 3 ex

 

The invention relates to the field of creating herbal medicines for weight loss, as well as to maintain optimal body weight in obesity.

The universal cause of many diseases, especially of the gastrointestinal tract, are poor diet, and overeating, which leads to the appearance of excess weight. Overweight people trying to get through starvation, through fasting diets or such is not always safe funds as Herbalife, Bromelain, fat, burner, Olympic and other However, after weight loss, a return to the usual diet, people are usually very quickly again, gaining weight, sometimes even more than before weight loss.

Known diet raw food diet (smoliar V.I. balanced diet. Kiev: Naukova Dumka, 1991, str-247). The essence of this diet is that are mostly lacto-vegetarian food, mostly raw or held minimal thermal processing (half-baked). However, for transition to raw food in its purest form requires 2-3 years, it is not suitable for people with diseases of the gastrointestinal tract. In addition, vegetarian diet is contraindicated in anemia, pancreatitis and hepatitis.

Known drugs based on medicinal plants, designed to control mA the son of the body. In many of them (for example, a series of teas "Slim", "Flying swallow", "slimming" and others) include vegetable raw materials with a diuretic and laxative effect. As a result, the effect of weight loss due to removal of fluid changes and intensification of the work of the intestine, which is temporary in nature, associated with the terms of use. Furthermore, often one of the active components of these products is Senna leaf (Alexandria leaf, Cassia), containing resinous substances, irritating the bowel. They can cause sharp pains, active motility.

The present invention is the use of non-toxic herbal drug for weight loss wide range of people with excess weight without showing any side effects.

The problem is solved as follows.

The invention relates to the field of creating herbal medicines for weight loss, as well as to maintain optimal body weight in obesity.

The proposed use of the drug "Alcohol" for the correction of body weight in obesity by oral administration of the drug for 18 days on 1 teaspoon 3 times a day.

"Alcohol" is a granular preparation containing an extract of Salsola Collina herb and vitamin C. Pre the Arat has shown excellent clinical results in diet therapy of hepatitis and for colds. "Alcohol" produced by OOO "PHYTOS"

Under supervision there were 30 men with obesity (age 46,5+7,6, body mass index and 36.2+6,2) and 15 men with normal body weight (age 40,7+1.9 years, a body mass index of 23.4+1,6). 15 men with obesity received within 18 days of the drug Alcohol" on 1 teaspoon 3 times a day with tea. Before and after administration of the drug was assessed feelings of appetite, body mass index (weight/height m2), the content of proinsulin (kits DRG, USA), and the parameters lipidtransportnoy system and routine metabolic indices (sets firm Karma Diana)

Results: 9 out of 15 patients receiving "Alcohol", reported lower feelings of appetite. All patients used a food additive has provided for a reduction in weight from 2 to 5 kg (table 1).

Of the patients before administration of the drug was a high index of body and 4 times higher levels of proinsulin, testified to the presence of insulin resistance. As a result of taking supplements yielded significant changes in both indicators towards the norm.

Table 2 presents data on the status of the transport of lipids in obese patients under the influence of reception "Alcohol"

From table 2 it follows that in patients with obesity as a result of taking "Alcohol" not received any significant changes in the state lipidtransportnoy system. Apparently, this is due the insufficient duration of treatment.

Table 3 presents data on routine parameters of serum.

From table 3 it follows that patients prior to the admission of Alcohol in serum was elevated glucose, uric acid, bilirubin and transaminase activities and γ-GGT. As a result of taking a fully normalized content of bilirubin and activity of Alat and γ-GTT. In addition, reduced levels of glucose, uric acid, AST. Some of the increase in the level of urea in the range of normal values may indicate stimulation of neutralizing liver function tests (urea)

Examples.

Example 1. Patient A., 42, weighing 102 kg took "Alcohol" on 1 teaspoon 3 times a day with tea. After 18 days, the body weight was 99 kg, the content of proinsulin decreased from 13,01 to 10.5.

Example 2. Patient D. 39 years old weighing 92 kg took "Alcohol" on 1 teaspoon 3 times a day. After 18 days, the body weight was 88 kg, the content of proinsulin decreased from 12.5 to 9.9.

Example 3. Patient N. 54 years old with a body weight of 95 kg took "Alcohol" on 1 teaspoon 3 times a day. After 18 days, the body weight was 90 kg, the content of proinsulin decreased from 11.1 to 8.1

When 18-day use "Alcohol provides reduced weight by 2.9 units of body mass index, reduces the feeling of appetite.

When 18-day use "Alcohol provides p is a positive influence on the indices of insulin resistance (reduced proinsulin and glucose).

When 18-day use "Alcohol" does not affect the transport of lipids in the blood.

When 18-day use "Alcohol" has a positive impact on the level of uric acid, bilirubinaemia and activity of marker enzymes of liver damage.

The weight loss with the application of Alcohol" is normalizing the nature and involves recovery of the organism as a whole by improving liver function, regulation of metabolism. A positive effect on liver and biliary system is expressed, in particular, in reducing the activity of the marker lesion (bilirubin and permentaly aminotransferase (al Al) and γ-glutamyltransferase (γ-GGT) and other

In addition, normal cholesterol, which is an indicator of atherogenic index, and as a result of structural changes produced bile decreases her ability to concentrate and form excrement. Regulatory impact on the metabolism of sugars is manifested in the reduction of the level of proinsulin and glucose.

Blood biochemical parameters of patients and the performance lipidtransportnoy system take into account the results presented in table 2 and 3.

The amino acid composition of the extract of Salsola Collina implies elevated levels of circulating amino acids (more rapid onset of feelings is asimenia) stimulation insulinopenia due to the presence of amino acids with branched radicals (more efficient utilization of food components), increased urea formation and conjugation with taurine (to support a neutralizing function of the liver (Chirkin A.A. and other Amino acid composition of Salsola Collina and their application for the correction of age-related changes in metabolism. Bulletin of pharmacy, 1984, No. 4, pp.24-30).

Studies have shown that it is advisable to extend the term of reception "Alcohol". Clinical results the 3.5 years of the drug show that it is possible to maintain a stable body weight for a long time. No negative effects so far not been identified.

Table 1
The effects of taking alcohol on the body mass index and level of Proinsulin
IndexControlBefore takingAfter taking
The body mass index23,4±1,636,2±6,2433,3±2,15*
Fasting proinsulin (pmol/l)3,32±1,413,06±1,749,67±1,59*
Note: 1* - P<0.05 compared with before treatment
Table 2
The performance lipidtransportnoy system in patients
IndexControlBefore takingAfter taking
Total cholesterol mmol/l4,69±0,635,66±0,91*5,69±0,94*
XC LPWN, mmol/l1,29±0,321,20±0,281,24±0,25
XC LPWN, mmol/l2,83±0,553,19+1,023,50+1,05*
Triglycerides, mmol/l1,11±0,552,77±1,84*2,01±1,32*
The atherogenic index3,38±2,414,06±1,833,79±1,51
Application: * to 0.05, compared to control.
Table 3
Routine biochemical parameters of blood serum
IndexControlBefore takingAfter taking
Glucose, mmol/l 4,78+0,656,57±1,71*5,65±0,62
Urea, mmol/l5,76±1,405,35±1,626,55±1,26*
Uric acid mmol/l259±52,6433±170,0*357±89,0*
Bilirubin, Ámol/l11,7+2,7316,1±5,07*11,2±3,09*
Alat, u/l22,1±14,3177,6±86,32*30,6±10,1*
AST, u/l28,59±10,1266,1±48,70*40,5±19,81*
Chess Federation, E/l84,6±16,995,0±21,683,34±to 20.28
γ-GGT, u/l30,4±24,575,4±43,6*48,2±27,4*
Application: * - P<0.05 compared with control. * - P<0.05 compared with before treatment.

The use of the drug "Alcohol" for the correction of body weight in obesity by oral administration of the drug for 18 days, 1 tsp 3 times a day.



 

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