Agent for treatment of infectious diseases


FIELD: medicine, pharmaceutical industry, phytotherapy.

SUBSTANCE: invention proposes an agent used in treatment of infectious diseases. Agent used in treatment of infectious diseases comprises chitosan of polyfraction composition with amine groups of molecular mass from monomeric link - glucosamine to ˜350 kDa and deacetylation degree from ˜68 to ≤ 95% and vegetable raw aqueous extract chosen from the following group: Cetraria thallus, sage official herb, cocklebur leaves, black poplar buds, common wormwood herb, red roots, burdock roots, French honey-suckle herb, bur-marigold tripartite herb, sandy common immortelle flowers, dropwort elm-leaved flowers, river avens (Geum) roots, licorice glabrous roots, swampy sweet flag roots, burnet official roots,, nettle dioecious herb, swampy cudweed herb, common milfoil herb, sweet clover official herb, gum-free leaves, dropwort, willow bark, birch leaves, bilberry leaves, willow-herb narrow-leaves herb, peppermint herb, fenestrate Saint-John's-wort herb, knot-grass herb, shepherd's purse herb, violet pensy tricolor herb, speedwell herb, pot-marigold flowers, common tansy flowers, matricary official flowers, chicory roots, dandelion official roots, tormentil roots, cinnamon wild rose fruits, viburnum leaves, pinnate kalanchoe and maize stigmas. Aqueous extract is prepared by extraction of vegetable raw with demineralized water under definite conditions. Agent promotes to effective treatment of infectious diseases, such as chlamydiosis, herpes, erysipelas, viral hepatitis A and B, gastroenteric tract diseases, acute enteric infectious, and to declining period of clinical symptoms of diseases said.

EFFECT: valuable medicinal properties of agent.

10 cl, 2 dwg, 12 ex

 

The invention relates to the field of clinical phytologie and herbal medicine and is concerned with the obtaining of biologically active substances of natural origin based on complexes of water-soluble forms of chitosan - chitodes with a dry extract of plant material, which can be used in medicine as a means for the treatment of infectious diseases in veterinary medicine and cosmetics.

Recently, widespread treatment-and-prophylactic means on the basis of phitochitodes - molecular complex of chitodes - water-soluble forms of chitosan with a dry extract of plant materials.

It is known for the treatment of bronchial asthma and related respiratory diseases, containing a mixture of water-soluble forms of dietary chitosan and dry extract of herbs specially formulated to be used in different dosage forms (Patent RU NO. 2172634, a 61 K 35/78, publ. 27.08.2001).

The disadvantage of analogue is the limited range of biological activity.

You know the mean of "HiColor" for the treatment of viral hepatitis b and C, including powder creation of phyto compositions pectinesterase medicinal plants, powder water-soluble low molecular weight chitosan and the filler is starch or carboxymethylcellulose (Patent RU №2185185, a 61 K 35/78, publ. 20.07.2002).

However, we know the mean of "HiColor" limited narrow anti-infective focus.

Known biologically active agent based on phitochitodes in the form of a molecular complex of a dry extract of medicinal plants or herbal and water-soluble forms of chitosan molefractions composition with molecular weight of Monomeric link - glucosamine to ˜150 kDa and a deacetylation from ˜68 ≤95% (Patent RU №2204402 a 61 K 35/78, publ. 20.05.2003).

The disadvantage of this is similar to the use of chitosan molefractions composition with molecular weight of not greater than 150 kDa, which limits the bacteriostatic activity of the salt form of chitosan (Chervinets V.M. abstract of Prof. Diss. M. April 2002). In addition, conditions for obtaining extracts phytos burs do not contribute to the extraction of plant lectins without changing their structure (the Study and application of lectins. "Lectins in biology and medicine". Scientific works of the University of Tartu. Vol.2. 1989; Krapivin LI Lectins hexaploid wheat. Abstract of Diss. Kida. Biol. Sciences. 1988. Saratov).

The closest analogue is a comprehensive herbal drug for the treatment of infectious diseases, representing a mixture of water-soluble chitosan and dry aqueous extract of medicinal plants at doses of components on a single receiving 25 mg and 22-25 mg (Patent RU №2174000 AND 61 TO 31/722, publ. 22.02.2000).

However, izvestiareports has poor efficiency due to incomplete extraction of biologically active substances.

The objective of the invention is to develop a new effective and affordable tools for the treatment of infectious diseases, which can be used both independently and in combination with other drugs.

The technical result of the invention consists in the creation of new tools for the treatment of infectious diseases that reduce the duration of clinical manifestations of infectious diseases of various etiologies.

The invention consists in the following: for the treatment of infectious diseases, characterized in that it contains chitosan molefractions composition with amine groups of molecular weight from unit link - glucosamine to ˜350 kDa and a deacetylation from ˜68 ≤95%, aqueous extract of the plant materials selected from the group: thallus tsetrariya, herb, Salvia officinalis, leaf cocklebur, black poplar buds, herb wormwood, red root, burdock root, herb Hedysarum and Bidens tripartite, color immortelle sandy and meadowsweet the roots of gravitate river, licorice, sweet marsh and medicinal Burnet, herb nettle, cudweed herb brown, yarrow and clover medicinal, eucalyptus leaves, willow bark, leaf birch and blueberry, grass fireweed herb,peppermint, Hypericum perforatum, knotweed, shepherd's purse, violet tricolor and Veronica Asherah, color calendula, tansy and chamomile, chicory roots of the dandelion, tormentil panostaja (galangal), rosehips and cinnamon, leaf viburnum, Kalanchoe Cirrus and corn silk, however, he obtained by extraction of plant raw materials demineralized water at a temperature of not more than 65°for 1-48 h and the ratio of extractant: raw materials (3-5):1.

For treatment of chlamydia tool (phitochitodes-33) contains extracts of vegetable raw materials of the following composition: thallus tsetrariya, herb, Salvia officinalis, leaf cocklebur, buds of poplar and grass wormwood, red root in equal quantity; herpes (phitochitodes-18): burdock root, herb Hedysarum and Bidens tripartite, color immortelle sandy and meadowsweet, black poplar buds, roots of gravitate river and licorice in equal quantity; Roger (phitochitodes-15): the roots of calamus swamp, medicinal Burnet, licorice, herb nettle, cudweed herb brown, yarrow and clover medicinal, eucalyptus leaf, meadowsweet, willow bark in equal quantity; in chronic hepatitis and pancreatitis (phitochitodes-07): leaf of birch and blueberry, grass fireweed uz is elitnogo, peppermint, St. John's wort, yarrow and clover medicinal, color calendula, chicory roots and calamus swamp in equal parts; in chronic hepatitis C cytolytic syndrome (Geppert - phitochitodes-14): hips cinnamon, licorice roots bare, grass peppermint and Hypericum perforatum in two parts, grass nettle and sweet clover medicinal, leaf viburnum one part; in chronic hepatitis and hypotonic dyskinesia (phitochitodes-12B): herb nettle and knotweed in three parts, color immortelle sandy and roots of licorice on two parts, melilot drug - half part; in chronic hepatitis and hypertension dyskinesia (phitochitodes-12K): herb nettle and knotweed in three parts, corn silk and the roots of the licorice in two parts, melilot drug - half part; in viral hepatitis a and b with biliary dyskinesia (phitochitodes-11): the roots of dandelion, color tansy, chamomile and calendula, corn silk, grass clover medicinal, Kalanchoe Cirrus, knotweed and nettle in equal quantity; infectious diseases of the gastrointestinal-intestinal tract and acute intestinal infections (phitochitodes-06): short and sweet marsh, cinquefoil panostaja (galangal), licorice, herb nettle, shepherd's purse, cudweed herb brown, yarrow, wormwood, violet tricolor and Veronica groves, eucalyptus leaf, color tansy, willow bark in two parts, grass clover medicinal - one part.

The proposed remedy for the treatment of infectious diseases was prepared as follows: to preserve the structure and properties of plant lectins first get extracts of plant materials in demineralized water by combining dry herbal with demineralized water, followed by exposure with periodic stirring for 1-48 hours at a temperature of not more than 65°and the ratio of extractant: raw materials (3-5):1. Then, after filtering the water extract to obtain a series of extracted substances from plant material, including plant lectins, with amine (and other functional groups of chitosan molecular weight from unit link - glucosamine to ˜350 kDa and a deacetylation from ˜68 ≤95%.

Increased effectiveness of the proposed remedies for the treatment of infectious diseases caused by complex application of chitosan containing different plants, using water-soluble chitosan molefractions composition, the polymer sciense ser the popular faction which has a higher bacteriostatic property and provides the prolonging effect of botanicals, and oligomeric fraction with sublingual application is rapidly absorbed into the blood, falling to the various organs and performs immunocorrective action. The dynamics of the penetration and removal of oligomers3H-chitosan in the blood and various organs clearly demonstrated by the study on mice of line C-57/SU (Fig. 1 and 2).

These data obtained on laboratory models allow us presume to say about this trend changes in the content of oligomeric chitosan (with the number of links in the chain from monomer - glucosamine to octamer) in the blood and various organs. Particularly important information about the dynamics of penetration and excretion of high-molecular3H-chitosan with MM 87 kDa when its introduction in the form of a solution in water and the infusion of medicinal plants used in obtaining phitochitodes-14 (Geppert) (figure 2).

Set that to 4 hours after administration of the tendency of the increase of chitosan content in the blood at ˜40% in comparison with the control experiment (introduction of water acidified solutions of chitosan). The content of chitosan in the liver during the time of observation, on the contrary, decreases, whereas the dynamics of the content in other organs are practically identical. Once in the liver, chitosan forms complexes with heparin, which have antikoaguliruyuschim action and the ability to activate the farm is you, removes inflammation, intoxication and restore liver [Y. Kikuchi, Macromol. Chem., 175, 2209, 3593. (1974)]. The fact of the increase of chitosan content in the blood may be due to the fact that some plant lectins can perform the role of chitinases and chitosanases, which will increase the oligomeric fraction of chitosan, penetrating into the blood and various organs.

It is important to emphasize that in order to increase the effectiveness of prevention of infectious diseases is essential to have vegetable pectins unchanged, their structure and the optimal ratio with a water-soluble form of chitosan molefractions composition, which is governed by the terms extraction and solvent/raw material.

A significant contribution to the effectiveness of the treatment of infectious diseases is expanding range of molecular weight of chitosan molefractions composition to 350 kDa, thereby increasing the sensitivity of pathogenic microorganisms to salt form of chitosan, especially in the inflammation of the mucosa of the gastrointestinal tract with sublingual route of administration of phytochitodes without the use of any liquid.

Chitosan and chitin, especially their water-soluble oligomeric digestible fraction can be considered as a building material for the synthesis of monopolised is the reeds in the connective tissue cells. When applied externally, chitosan not only quickly penetrates the skin through the mouth of the hair follicle and through the mouth glands, but also activates the enzymes gialuronidazu and β-glucuronidase responsible for diffusive processes in the extracellular matrix. If you use oral phytochitodes, as we have seen, it is also possible penetration of chitosan in the blood and various organs, and in this case will improve transport in the extracellular matrix of all human organs, and therefore, more effective will be diverted waste products of the cells and delivered food to the cells, it is more efficient to happen and salt metabolism. If you consider the antioxidant properties of not only the herbal extract and chitosan, for which these properties are enhanced in the presence of amino groups in the coordination sphere of the transition metal atom (Zn, Cu, Ni, Fe) [Mosquito B.A. Why chitosan useful to man? "New advances in the study of chitin and chitosan". Materials of the 6th Int. proc. 22-24 October 2001. M: VNIRO. 2001. S-195], phytochitodes, to a certain extent, can play the role of adaptogens, especially those phytochitodes, which are obtained on the basis of multicomponent fees medicinal plants, when the drug becomes rich not only different extractable organic substances, the composition close to adaptogene is, but the vital micro - and macroelements in easily digestible form.

The invention is illustrated by the following examples.

Example 1. Patient D., 49 years old, was observed in the outpatient setting. From the anamnesis it is known, that in the last 10 years disturb itching of the vulva, frequent cystitis, accompanied by frequent urination, pain in the eyes, pain in the joints - knee, hip. In the examination diagnosed with chlamydia urogenital, Reiter syndrome. The diagnosis was confirmed by the isolation of culture Ch. Trachomatis from cervical cancer, the detection of DNA of chlamydia in polymerase chain reaction (PCR), enzyme-linked immunosorbent analysis (ELISA) positive antibodies to chlamydia type JgG - 0,692 (+++), REEF smears, scrapings of the cervix, conjuctive - positive. Treated with phitochitodes-33 for six weeks with simultaneous douche decoction of wormwood (one month), use the ointment on the joints (a month and a half). Improvement was observed from the third week: gone itching of the vulva, pain in the eyes and when urinating, pain in the joints decreased and by the fifth week of the treatment is stopped. After treatment the results of control studies in PCR and immunofluorescence assay reaction (RIF) is negative. In ELISA antibody titers JgG decreased to normal values (0,225).

Example 2. Patient S., 38 years old, was observed in the outpatient setting. The diagnosis of urogenital chlamydia, discovered 3 years ago and confirmed in cell culture in ELISA and REEF. Were treated with traditional antibiotics (doxycycline, Sumamed). Discharged with a negative control studies in cell culture, ELISA, REEF. However, two years later chlamydia detected again against the backdrop of concerns clinic (pain in the joints, groin area, painful and enlarged inguinal lymph nodes, diarrhea up to two times with mucus, discharge from the urethra and anus, itching). In addition to chlamydia Ch. Trachomatis found a Ureaplasma. The patient again underwent a course of antibiotic therapy without effect. The disease is regarded as reinfection mix: chlamydia + ureaplasmosis, complicated by antibiotic therapy, asthma staph dysbiosis of the 3rd degree. Recommended treatment protivolednym the phitochitodes (6 weeks) in combination with tincture of birch buds (1 month), instalacije decoction of wormwood (3 weeks), bifidumbakterin (4 weeks). The patient's health has improved markedly. Control studies showed a negative result in cell culture, ELISA, REEF. After 3 months made PCR: DNA Ch. Trachomatis is not found.

Example 3. Patient P., 60, outpatient observed about often chronic recurrent herpetic infections affecting the skin and mucous membranes (type 1 and 2 in PCR). Suffering for 10 years, reci everyuser herpes localized to the mucosa of the lips and genitals, the skin of the wings of the nose and buttocks. Previously held therapy with the antiviral drugs acyclovir (spirits), alpizarinom interior and local, inducers of interferon and interferon (Amiksin, IFN, welfare), Poludan gave a temporary effect with short remission (from 2 weeks to 1 month). During exacerbation of herpes infection (confirmed by PCR - 1 and 2 type herpesvirus) assigned phitochitodes-18 and locally chitosan containing ointment prepared on the antiherpetic herbal. Course of treatment: 3 weeks intake of 1 tablet phitochitodes-18 to 4 times a day, one week, and simultaneous 2-week use of chitosan-containing ointments on the inflammation. Courses were repeated at exacerbation. After 1 year of treatment, relapse occurred at the end of the first month, however, wore a mild character. The following recurrence developed after 3 months, after 6 and after 1 year. There were 5 courses of treatment. Attention was drawn to significant changes in immune status. Before treatment: the decrease in the total pool of T-lymphocytes, violation of immunoregulatory index in the direction of suppression, blockade of cell serum factors, reduction of natural killer cells. After treatment all indicators of immunity came to normal. The patient is on maintenance therapy (1,2 courses per year as appropriate).

The use of the 4. Patient K., aged 65. Diagnosis: chronic recurrent erysipelas of the lower extremities. Lymphostasis. Within 5 years, suffering from recurrent erysipelas of the lower extremities with a recurrence rate of 3 to 5 times a year. The patient is on billingparadise. When relapse was used antibiotics (lincomycin, ampicillin, and others) lymphostasis increased relapse was repeated. Recommended during the year a month before relapse to start taking protivotarannogo phitochitodes - 15 on 1 tab. 3-4 times a day, sucking. The duration of intake phitochitodes 2-3 months with a repetition rate of twice a year - early spring and in the fall (prior to recurrence). Observation of the patient during the year indicate a decline in the number of relapses up to 1 times per year with mild clinical manifestations.

Example 5. Patient K., aged 52. Diagnosis: chronic cholecystoenteric, biliary dyskinesia. Ill for 5 years, from the time of diagnosis. Ultrasound of abdominal organs, liver enlargement, diffuse changes of a parenchyma of the liver and pancreas, thickening of the walls of the gall bladder atony, the presence of thick bile. Markers of viral hepatitis ( C, b, G) - not identified. Biochemical analysis of blood: bilirubin 17,4/16.0 g/L. ALT - 62, AST - 48 mmol/l, amylase - 405, alkaline phosphatase - 168, UFC - 96 u/l, LDF - 412 u/l Assigned phitochitodes-07 p is 1 tab. 3 times a day (to dissolve) for 30 min before a meal, milk Thistle - Maria - MK 1 teaspoon 3 times for 20 minutes before meals for three months with a break in 6 days. The control ultrasound after 3 months: the size of the liver in normal parenchyma rather uniform, wavy contours, the pancreas is not increased. Blood biochemical parameters: ALT-32, AST - 36 u/l, glucose - 5.7 mmol/l, amylase - 114 u/l, bilirubin-18.2 mmol/l, ck - 96, γGT - 29. Recommended to repeat the course.

Example 6. Patient S., aged 29, was on inpatient and then outpatient treatment. Diagnosis: acute viral hepatitis b, medium-heavy flow. The diagnosis is confirmed by specific markers of HBV infection. Biochemical parameters at entry: total protein -76,0, bilirubin - 90/64 g/l, ALT - 1450 mmol/l, AST - 930 mmol/l, alkaline phosphatase -430, prothrombin index is 76%. Markers: HBsAg+, anti-HBCor JgM+. Conducted basic detoxification therapy (in/in the glucose, vitamins, Riboxin), against which General condition improved, intoxication syndrome decreased. Noted improvement in biochemical parameters: the reduction of bilirubin to 45/30 g/l, TRANS-Minas ALT - 1000 mmol/l, AST - 620 mmol/l In the period of reconvalescent-tion for a long time remained cytolytic syndrome: ALT - 800, AST - 500 mmol/L. Appointed phitochitodes-14 1 tab. under the tongue 3 times a day for two weeks. To the monitoring study of biochemical parameters bilirubin - 19 g/l, ALT - 56 AST - 40 mmol/l, alkaline phosphatase - 120, HBsAg in the blood has not been determined. The treatment continued for another two weeks. All benchmarks normalized.

Example 7. Patient K., 42 years was observed as outpatients with a diagnosis of acute viral hepatitis And in the stage of convalescence, a month before this was on statsionarnom treatment in the hospital. S. P. Botkin, where are diagnosed with acute viral hepatitis a based on the data of epidamnus, predzheltushnogo and icteric period of the disease, occurring with symptoms of cholestasis and cytolysis. The diagnosis was confirmed by the presence of markers of anti HAV JgM. Conducted basic therapy (gemodez, glucose, saline/vitamin C). Intoxication, cholestasis disappeared, however, when the extract was preserved hyperferritinemia: ALT - 420, AST - 360 mmol/L. Appointed phitochitodes-14 one table. 3 times a day. After 2 weeks made control studies of biochemical parameters of blood, which had normal value: bilirubin is 14.5/9.5 g/l, ALT - 42 mmol/l, AST - 32 mmol/l, alkaline phosphatase - 128. Total protein 75 g/l

Example 8. Patient K., 25 years. Diagnosis: acute viral hepatitis a, medium-heavy, delivered on the basis of these epidamnus (contact with someone who has hepatitis a), the presence of prodromal period for influenza-like variant, presence of jaundice, hepatomegaly, cholestasis and cytolytic syndrome. On twigden presence of antibodies JgM to hepatitis A. Upon admission to the hospital (in the period of jaundice) biochemical analysis of blood: bilirubin 110/80 g/l, ALT - 650, AST - 350 mmol/l, alkaline phosphatase - 640. Conducted basic therapy (glucose, vitamin C, gemodez). After 10 days, the condition has improved, but remained jaundice, mild itching of the skin. During the control study of blood: LAT - 80, AST - 50 mmol/l, bilirubin - 100 / 80g g/l, alkaline phosphatase - 520. Ultrasound: effects hepatomegaly, diffuse changes of a liver, a gall bladder atonic, contains thick bile, moderate changes in the pancreas. Appointed phitochitodes-12B 1 tab. 3 times a day, powder milk Thistle on 1 teaspoon 3 times a day 30 minutes before meals. Control studies of biochemical blood test in two weeks: bilirubin - 25 g/l, transaminases returned to normal, ALT - 30 AST - 20 mmol/l, alkaline phosphatase - 120. Continued treatment pickittm-12B. Ultrasound in a month: moderate changes in the parenchyma of the liver, gall bladder reduced biliary dyskinesia. All biochemical parameters in norm.

Example 9. Patient P., 24 years was observed in the outpatient setting. A month ago she was hospitalized about viral hepatitis A. In the period of convalescence continued hyperbilirubinemia, periodically had pain in the right hypochondrium, bitter taste in the mouth. Biochemical analysis of blood: bilirubin - 60/48 g/l, ALT - 32, AST - 38 mmol/l, alkaline phosphatase -390 IU/l, with ultrasound: moderate hepatomegaly, reasonable price is by diffuse changes of a liver, the thickened gallbladder wall, the tone of the gall bladder tense, the parenchyma of the pancreas homogeneous. Appointed phitochitodes-12K 1 tab. 3 times a day 30 minutes before meals under the tongue for two weeks. The results of the control biochemical tests: bilirubin to 18.5 g/l, ALT - 28, AST - 36 mmol/l, alkaline phosphatase - 140 u/L. When ultrasound in a month - still thickening of the walls of the gall bladder, the voltage of the tone, which was seen as the formation of chronic cholecystitis, biliary dyskinesia in hypertensive hyperkinetic type. Recommended to continue taking phitochitodes-12K up to a month.

Example 10. Patient B., aged 54, was observed in the outpatient setting. Diagnosis: chronic viral hepatitis b in Exodus in cirrhosis, moderate activity at the stage of subcompensation. For 5 years suffer from chronic hepatitis C. was Treated with lamivudine, against which the activity of the process decreased. Last year antiviral therapy does not accept. Revealed cirrhosis of the liver stage of subcompensation. When ultrasound cirrhosis confirmed. Biochemical parameters blood bilirubin increased to 180 g/l, LAT - 550, AST -400 mmol/l, alkaline phosphatase up to 300 u/L. the Ongoing basic therapy, including enzymes, antispasmodics, Heptral, diuretics, resulted in reduction of transaminases half, bilirubin remained high (110 g/l). Appointed phitochitodes-11 is about 1 PL. 3 times a day 20 minutes before meals under the tongue. Within two weeks of receiving the condition has improved, the performance of bilirubin decreased significantly (up to 30 g/l), but transaminases remained elevated, ALT - 98, AST - 72 mmol/L. Additionally assigned Geppert (phitochitodes-14). Two weeks later, follow-up studies of biochemical parameters of blood testified to the compensation process.

Example 11. Patient S., 38 years old was admitted to the hospital with complaints of fever, abdominal pain, cramping in nature, frequent stools in small portions with admixture of mucus and blood. Diagnosed with acute dysentery Flexner, confirmed the allocation of the Shigella Flexner 2A. When RRS-a survey of painting catarrhal-erosive proctosigmoiditis, sphincteric. Appointed phitochitodes-06 1 tab. 4 times a day (to dissolve), enterosorbent "pekto", no-Spa. The patient's condition had improved by the end of the day: decreased abdominal pain, stool frequency decreased, disappeared impurities in the blood. In subsequent observed regression of the symptoms. When RRS-study after 5 days - pathology of the intestinal mucosa is not revealed. Control bacteriological sowing stool dysentery and intestinal - negative.

Example 12. Patient E, 38 years. Diagnosis: viral hepatitis b, medium-heavy, complicated, cholecysto-pancreatitis. Ill for months, d is Agnes hepatitis b confirmed markers: Hbs Ag+, anti HBCor IgM+, DNA-HBV+. On the 4th week of the disease on the background of decreasing transaminase (ACT 60, AST - to 45 mmol/l) and improve the overall condition after errors in diet pains shingles character and in the right hypochondrium, increased temperature, increased blood leukocytosis with 6000 to 12000 and amylase to 600 units Diagnosed cholecysto-pancreatitis. Ultrasound liver enlargement, diffuse parenchymal liver and pancreas, thickening of the walls of the gallbladder. To therapy (antibiotics, detoxification) have developed drug disease. In this regard, on the 6th day appointed phitochitodes-07-three times a day 1 tablet to dissolve for 30 minutes before a meal and liquid. On the background of therapy all biochemical parameters returned to normal after 10 days. Within three months the patient took phitochitodes-07 weekly intervals after the month of admission under this scheme. The control ultrasound in 6 months: signs of pancreatitis have been identified, stored diffuse changes of a liver and thickening of the walls of the gallbladder. It is recommended to repeat the course phitochitodes three months.

1. For the treatment of infectious diseases, characterized in that it contains chitosan molefractions composition with amine groups of molecular weight from unit link - glucosamine to ˜350 kDa and degree of DEA is melirovanie from ˜ 68 to ≤95%, aqueous extract of the plant materials selected from the group: thallus tsetrariya, herb, Salvia officinalis, leaf cocklebur, black poplar buds, herb wormwood, red root, burdock root, herb Hedysarum and Bidens tripartite, color immortelle sandy and meadowsweet, the roots of gravitate river, licorice, sweet marsh and medicinal Burnet, herb nettle, cudweed herb brown, yarrow and clover medicinal, eucalyptus leaf, meadowsweet, willow bark, leaf birch and blueberry, grass fireweed herb, peppermint, Hypericum perforatum, knotweed, shepherd's purse, violet tricolor and Veronica Asherah, color calendula, tansy and chamomile, chicory roots of the dandelion, tormentil panostaja (galangal), rosehips and cinnamon, leaf viburnum, Kalanchoe Cirrus and corn silk, however, he obtained by extraction of plant raw materials demineralized water at a temperature of not more than 65°for 1-48 h and the ratio of extractant: raw=(3-5):1.

2. The tool according to claim 1, characterized in that for the treatment of chlamydia contains extracts of vegetable raw materials of the following composition: thallus tsetrariya, herb, Salvia officinalis, leaf cocklebur, buds of poplar and grass wormwood,red root in equal number.

3. The tool according to claim 1, characterized in that for the treatment of herpes it contains extracts of vegetable raw materials of the following composition: burdock root, herb Hedysarum and Bidens tripartite, color immortelle sandy and meadowsweet, black poplar buds, roots of gravitate river and licorice in equal number.

4. The tool according to claim 1, characterized in that for the treatment of faces contains extracts of vegetable raw materials of the following composition: the roots of calamus swamp, medicinal Burnet, licorice, herb nettle, cudweed herb brown, yarrow and clover medicinal, eucalyptus leaf, meadowsweet, willow bark in equal number.

5. The tool according to claim 1, characterized in that for the treatment of viral hepatitis b contains extracts of vegetable raw materials of the following composition: leaf of birch and blueberry, grass fireweed herb, peppermint, St. John's wort, yarrow and clover medicinal, color calendula, chicory roots and calamus swamp in equal parts.

6. The tool according to claim 1, characterized in that for the treatment of viral hepatitis a and b contains extracts of vegetable raw materials of the following composition: hips cinnamon, licorice roots bare, grass peppermint and Hypericum perforatum in two parts, grass nettle and sweet clover Lakers the public, leaf viburnum one part.

7. The tool according to claim 1, characterized in that for the treatment of viral hepatitis a, followed by hypotonic dyskinesia, contains extracts of vegetable raw materials of the following composition: grass nettle and knotweed in three parts, color immortelle sandy and the roots of the licorice in two parts, melilot drug - half part.

8. The tool according to claim 1, characterized in that for the treatment of viral hepatitis a involving hypertensive dyskinesia, contains extracts of vegetable raw materials of the following composition: grass nettle and knotweed in three parts, corn silk and the roots of the licorice in two parts, melilot drug - half part.

9. The tool according to claim 1, characterized in that for the treatment of viral hepatitis a and b, accompanied by biliary dyskinesia, contains extracts of vegetable raw materials of the following composition: roots of dandelion, color tansy, chamomile and calendula, corn silk, grass clover medicinal, Kalanchoe Cirrus, knotweed and nettle in equal number.

10. The tool according to claim 1, characterized in that for the treatment of infectious diseases of the gastrointestinal tract and acute intestinal infections contains extract of plant materials the trail of the total composition: the roots of calamus swamp, cinquefoil panostaja (galangal), licorice, herb nettle, shepherd's purse, cudweed herb brown, yarrow, wormwood, violet tricolor and Veronica groves, eucalyptus leaf, color tansy, willow bark in two parts, grass clover medicinal - one part.



 

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3 ex, 1 tbl

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: invention relates to an antibacterial, anti-inflammatory, antiviral, antiherpetic agent used for treatment of vulvovaginitis, palanitis, ballanopostitis induced by microorganisms, candidas, viruses, chlamydia, trichomones and infections of herpes simplex virus and for treatment of acne also. Invention relates to an antibacterial, anti-inflammatory, antiviral, antiherpetic medicinal agent used for treatment of diseases transferred by sexual way, in particular, to vulvovaginitis, palanitis, ballanopostitis induced by microorganisms, candidas, viruses, chlamydia, trichomones and infections of herpes simplex virus and for treatment of acne. The medicinal agent comprises a mixture of cream-like base (vehicle) and an alcoholic extract from leaves, fruits and stems of plant Tribulus terrestris (active component). This active component comprises active substance from Tribulus terrestris with the high content of steroid saponins. Also, invention relates to a method for preparing an antibacterial, anti-inflammatory, antiviral, antiherpetic medicinal agent that involves analysis of parts of plant Tribulus terrestris for gathering and further extraction, namely to a sample of leaves, fruits and stems of plant Tribulus terrestris gathered in the definite time period. Method involves addition of deionized water, stirring and evaluation of the level of water and foam in a mixer. After proving readiness of plant Tribulus terrestris for gathering samples of leaves, fruits and stems of plant Tribulus terrestris are taken. Samples are dried, milled and deionized water is added. The prepared aqueous mixture is treated in mixer, the level of water and foam is evaluated in an aqueous mixture. The prepared mixture is remained for precipitation, filtered, ethyl alcohol is distilled off and the concentrated aqueous extract is prepared. The prepared active component is added to the cream base (vehicle) or to a base (suppository). Agent promotes to effective treatment of vulvovaginitis, palanitis, ballanopostitis induced by microorganisms, candidas, viruses, chlamydia, trichomones and infections of herpes simplex virus and to treatment of acne also.

EFFECT: valuable medicinal properties of agent.

5 cl, 5 dwg

FIELD: medicine, pharmacology, pharmacy.

SUBSTANCE: antiviral agent comprises aciclovir as an active substance and special additives wherein agent comprises potato starch, talc, stearic acid or stearates as special additives taken in the definite ratio of components. Antiviral agent is made as a tablet. Also, invention relates to a simple method for preparing an antiviral agent and invention provides rapid release of active component. Invention can be used for treatment of skin and mucosa viral diseases induced by herpes simplex virus or herpes zoster virus, and for prophylaxis of these diseases in patients with damage of the immune system.

EFFECT: improved method for preparing, valuable medicinal properties of agent.

4 cl, 1 tbl

FIELD: organic synthesis.

SUBSTANCE: invention provides group of novel antiviral nitrogen-containing compounds, in particular adamantane derivatives having general formula:

, wherein R represents chlorine or ethyl.

EFFECT: increased choice of biologically active compounds suitable for use in medicine as antiherpetic agents.

2 cl, 6 tbl, 3 ex

The invention relates to the field of pharmaceutical industry and relates to pharmaceutical compositions for the treatment of herpes virus infection

The invention relates to medicine, namely to the development of new combinations Antiherpes virus effect of actions

The invention relates to new biologically active phosphonate derivative of acyclovir

FIELD: medicine, pharmacy.

SUBSTANCE: invention represents a pharmaceutical tablet comprising a core and bound envelope wherein (a) core comprises solid particles of water-soluble dye dispersed in matrix, and (b) envelope comprises hellanic gum. Due to the presence of water-soluble dye in the tablet core it shows spotted shape that provides easy recognition of the tablet. The tablet is useful for peroral and intraoral administration.

EFFECT: improved and valuable properties of tablet.

30 cl, 6 ex

FIELD: immunology, biotechnology.

SUBSTANCE: invention describes antibody and its fragments neutralizing rabies virus and a method for treatment of patient subjected for effect of rabies virus by using indicated antibody and its fragment. Invention discloses variants of isolated nucleic acids encoding polypeptides carrying light and heavy chain of antibody, respectively. Also, invention describes expressing vector carrying at least one of indicated nucleic acids. Using this invention enhances span-life of patients after effect with rabies virus on them and can be used in corresponding prophylactic therapy of such patients.

EFFECT: valuable medicinal properties of antibody and nucleic acid.

14 cl, 1 dwg, 1 tbl, 2 ex

FIELD: veterinary science, surgery.

SUBSTANCE: method involves applying the application of mixture comprising glue base with ligfol and Novocain on infected surface taken in the ratio, wt.-%: ligfol, 70; Novocain, 30. Method allows decreasing time for treatment of suppurative wounds by 1.5-2 times, economy of dressing material and time that improved labor conditions of veterinary expert. Invention can be used in treatment of suppurative wounds both aerobic and anaerobic etiology.

EFFECT: improved treatment method.

1 ex

FIELD: veterinary science.

SUBSTANCE: invention involves the combined use of antibacterial preparations and immunomodulator. Method involves complex of single and double RNA sodium salts from killer yeast Saccharomyces cerevisiae as an immunomodulator and synthetic polymer-carrier taken in the dose 0.3-0.4 mg/kg. Immunomodulator is administrated in animals in a single dose before onset of critical period, i. e. in 15-20 days of piglets growing. Method provides stimulation of factors of cellular and humoral immunity of animals without adverse reactions and complication due to selection of optimal dose of immunomodulator and its prolonged effect.

EFFECT: improved method for treatment and prophylaxis.

3 cl, 4 tbl, 3 ex

FIELD: medicine, virology, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a synergetic composition comprising azidothymidine and glycyrrhizic acid penta-O-nicotinate - niglizine taken in physiologically blood concentrations: 0.0037-0.0254 mcM for azidothymidine and 0.0052-9.64 mcM for niglizine. Using the proposed composition provides effective inhibition of HIV-1 reproduction and significant reducing consumptions required for treatment. The composition shows high bioavailability and high effectiveness.

EFFECT: improved and valuable medicinal properties of composition.

6 tbl, 1 dwg

FIELD: veterinary science.

SUBSTANCE: invention proposes a preparation for treatment and prophylaxis of mastitis in cows at onset of the lactation period and in dry cows that comprises the following components, wt.-%: furacrylin, 0.4-0.6; dioxydin, 0.8-1.2; bee wax, 4-6, and sunflower oil, the balance. The preparation is heated to 38-40°C and administrated in cow mammary gland being in damaged and healthy lobules of udder through a nipple duct by using a syringe in the dose 5 ml. Using the preparation provides enhancing therapeutic and prophylactic effectiveness, decreasing labor intensity in treatment and prophylaxis of mastitis in cows at the lactation period and in dry cows.

EFFECT: enhanced and valuable properties of preparation.

3 tbl, 3 ex

FIELD: veterinary science.

SUBSTANCE: invention proposes a preparation for treatment and prophylaxis of mastitis in cows at onset of the lactation period and in dry cows that comprises the following components, wt.-%: furacrylin, 0.4-0.6; dioxydin, 0.8-1.2; bee wax, 4-6, and sunflower oil, the balance. The preparation is heated to 38-40°C and administrated in cow mammary gland being in damaged and healthy lobules of udder through a nipple duct by using a syringe in the dose 5 ml. Using the preparation provides enhancing therapeutic and prophylactic effectiveness, decreasing labor intensity in treatment and prophylaxis of mastitis in cows at the lactation period and in dry cows.

EFFECT: enhanced and valuable properties of preparation.

3 tbl, 3 ex

FIELD: pharmacy.

SUBSTANCE: invention relates to metronidazol-base antiprotozoan preparation possessing broad spectrum of action with respect to protozoa. Proposed agent is made as tablets based on metronidazol and comprises polyvinylpyrrolidone, filling agent and powdering agent also. Microcrystalline cellulose is used as a filling agent, and a mixture of cross-linked homopolymer of N-vinyl-2-pyrrolidone with the nitrogen content 11-12.8% and poly-(2-oxypyrrolidine-1-ylethylene) with K- viscosity value 22.5-26.7 and taken in the ratio = (1-5):1, respectively, is used as polyvinylpyrrolidone. Invention provides enhancing strength of tablet in combination with its rapid degradation in water.

EFFECT: improved pharmaceutical properties of agent.

1 tbl

FIELD: medicine, organic chemistry, pharmacy.

SUBSTANCE: invention relates to an antibacterial preparation based on α-aminosulfonic acid amide, i. e. N'-methyl-1-phenyl-1-N,N-diethylaminomethanesulfonamide that can be used in veterinary science. Invention relates to expanding assortment of agents used against pathogenic pathogen with a preparation relating to class of α-aminosulfonic acid amides eliciting antibacterial activity being without cumulative properties and pathological changes in animal organs and tissues.

EFFECT: valuable veterinary properties of preparation.

1 tbl, 1 ex

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to synthesis of new polyelectrolytes of cationic type based on diallylamine trifluoroacetate representing monomers of order both N,N-diallylamine and N,N-diallyl-N-methylamine. Invention describes polydiallylamines of the general formula: wherein R means hydrogen atom (H), -CH3; n = 107-308 (weighted mean degree of polymerization); molecular mass = 24000-65000 g/mole (weighted mean molecular mass); width of molecular-mass distribution δ = 1.85. Their aqueous solution can be used as a disinfecting agent in the minimal inhibitory concentration from 1.25 x 10-4 g/ml to 1.5 x 10-6 g/ml. Invention can be used in different branches of industry, in particular, in medicine.

EFFECT: valuable properties of compounds.

2 cl, 5 tbl, 4 dwg, 2 sch

FIELD: medicine, hepatology, chemical-pharmaceutical industry, biotechnology.

SUBSTANCE: invention relates to a biotransplant used in treatment of chronic hepatitis and liver cirrhosis and comprising mesenchymal stem cells obtained from fetal or donor material. The parent tissue is subjected for disaggregation followed by culturing as fixed colonies in the growth medium containing fetal calve serum and glutamine and passage at low density value with change of medium composition and cultivation is carried out without accumulation cells with mature stroma in culture. Also, invention relates to a method for treatment of chronic hepatitis and liver cirrhosis that involves administration of indicated biotransplants by using venous catheter or by puncture in the portal system veins, or by using arterial catheter in splenic artery, or by puncture in spleen parenchyma, or by intraperitoneal route, or by puncture in gastrocolic omentum. Invention provides enhancing effectiveness in complex effect on damaged liver.

EFFECT: improved preparing method, improved treatment method.

13 cl

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