Method of curing ischemic heat disease, i-ii functional class exertional angina

FIELD: medicine; cardiology.

SUBSTANCE: method includes magnetic-laser influence of pulse laser radiation onto cubitus. Course of treatment includes 10 procedures with duration of 7 minutes each. First 5 procedures are taken daily and the rest ones - every other day. Laser radiation power density equals to 8,93 mW/mm2, magnetic induction is 50 microtesla. From the first day of treatment, the respiratory gymnastics should be done to work out diaphragm breathing by training. For the purpose, patient moves actively with his/her front abdominal wall when breathing through nose in and when breathing out he/she pulls belly inside through close lips. Breathing frequency equals 3-5-7 times a minute, duration of procedure equals to 13-20 minutes.

EFFECT: improved of adaptive abilities of human body; normalized lipidic exchange; prolonged period of remission.

2 ex, 9 tbl

 

The invention relates to medicine, namely cardiology, and can be used in the treatment of coronary heart disease, strokes voltage I-II functional class.

There is a method of treatment of coronary heart disease through the use of a 12-day psycho-emotional functional rehabilitation of patients with coronary artery disease using the method of training the regulation of respiration and heart rate method biofeedback (BFB) using equipment company "Boswash" in cyclic mode (Tymoshenko O.V. Methods of biofeedback in the rehabilitation of patients with ischemic heart disease for health stage. // Biofeedback. - 2000. No. 1. - P.56).

Closest to the claimed method is a method of treatment of coronary heart disease, strokes voltage I-II functional classes (Patent RU №2147248, C1, 10.04.2000), including magnetic effect by irradiation of the cubital vein pulsed laser radiation with pulse frequency of 1500 Hz.

However, this method is ineffective in the multifactorial prevention and treatment of heart disease.

The objective of the invention is to increase the adaptive capacity of the organism, normalization of lipid metabolism, lipid peroxidation and antioxidant system, improve therapeutic effect is Vesti, the reduction of treatment time, the lengthening of remission.

The problem is solved in that the magnetic effect is carried out at a power density of laser radiation 8,93 mW/mm2magnetic induction - 50 MT, with the first day of treatment daily breathing exercises with development of diaphragmatic breathing through training, in which the patient makes inhaling through the nose of active movement of the anterior abdominal wall of the abdomen, and when breathing out through closed lips belly draw, respiratory rate is 3-5-7 in 1 minute, the duration of the session 13-20 minutes.

Method of biological feedback, which carry out training the regulation of respiration and heart rate, contributes to the prevention and treatment of risk factors for CHD, as psycho-emotional stress. The basis for the development of abdominal relaxation type of breathing is breathing arrhythmia (heart rate on the inhale minus the heart rate on the exhale), which becomes the maximum 9.7±0.89 to 12,7±0,80 beats./min respiratory rate from 3 to 7 in 1 minute. Respiratory arrhythmia of the heart reflects the influence of the parasympathetic nervous system on the heart rate and blood pressure level.

The technical result of the proposed method is:

- raising hell is plivnyh of the body (changes in hemodynamic lower levels of blood pressure - systolic blood pressure 17.5% (<0.05)and diastolic blood pressure by 21.9% (p<0.05), and heart rate of 2.4% (p>0,05); emotional adjustment - a decrease in the level of situational anxiety by 47.4% and trait anxiety by 26.3%, reduction of neurotic complaints 33.9%, increase in the number of patients with the most favorable adaptation reactions increased activation versus 38.2%);

- normalization of lipid metabolism - decrease in the atherogenic plasma lipids and increased cholesterol high density lipoprotein; lipid peroxidation - reducing degradation products of lipid malonic aldehyde lipids and red blood cells; antioxidant system - increase in the level of catalase and ceruloplasmin; decrease coagulating activity and increased fibrinolytic properties of blood - reduction of fibrinogen by 22.7%, increase tolerance to heparin plasma 184%, kaolinovogo time a 30.6%increase in fibrinolytic activity of plasma 32.7%;

- increase therapeutic efficacy - high percentage of improvement (97.1 per cent) of the main clinical and functional parameters (subjective symptoms, ECG data, emotional stability) to the middle of the course of treatment (5-session biofeedback);

- reduction of treatment time (complex designed for 16 days, with a 21-day stay of the patient at the resort);

- prolonged remission therapeutic effect persists for 8.3 months without exacerbation of the main disease.

Thus, the complex physiological method, harmless, no complications, has sufficient therapeutic, medical and economic efficiency.

The method is as follows.

Biofeedback method is carried out with the help of computer equipment biofeedback - complex Cardio-pulmonary", serial No. 2000805 (703)company CJSC Biswasi" St. Petersburg; cardiocirculatory KS-02, mass production of CJSC Biswasi" (St. Petersburg), No. 3828511 of Gosstandart of Russia and ROCC EN. 0001.11 ME 20; per. the identity of the health Ministry of the Russian Federation No. 92/135-94.

The office barefoot cardio-pulmonary equipped computer with a cardiovascular machine that is developed at the Institute of experimental medicine RAMPS intended for carrying out of sessions per patient in a calm emotional atmosphere. The patient is sitting in a comfortable chair with high back and position your hands on the arms in a comfortable position. On the chest in the region of the fourth or fifth intercostal space on crenelations lines impose smartpause electrodes intended for registration of the ECG signal, and on the abdomen above the navel using a special elastic belt impose sensor breathing.

The patient is offered the method of breathing exercises with development skill abdominal-relaxation the ionic type of breathing to achieve the maximum synchronization of breathing and heart rate (HR) (inhalation - Heart rate increases, exhale heart rate decreases) and the increase in the difference between the curves on the breath and heart rate on the exhale, called respiratory arrhythmia (DAS). The biofeedback session consists of three minutes of training and one minute of rest. In the first 2 days prior to the session the patient provide 1 minute of rest. In biofeedback training, the patient performs active movement of the anterior abdominal wall of the abdomen on random breath through the nose, the stomach protrudes, with a slow quiet exhalation through polusognutye lips belly slowly retracted. During the training on the monitor screen show slides and sounds calm relaxing music. Respiratory rate when done correctly, is 3-5-7 in 1 minute. Each period of training alternated with a rest period, during which the patient is breathing without effort. During the whole session is registration of heart rate maximum heart rate minimum heart rate average breathing rate per minute, the DAS with the construction of graphical and tabular images of the session results. The duration of the session from 13 to 20 minutes a day, at 10 on the course, from the first day of stay in hospital.

Methodology lasermagnetic vessels irradiation of blood performed with use of therapeutic laser pulse "LT-1" (registration number 93/199-100 state register of medical products, 1996) and us is established at the emitter of the annular magnetic nozzle To # 44-24-9,3 mm with magnetic induction in the cavity of the window of the applicator 50 MT, kit MA-1-001 for laser and biophysical devices (registration number 94/271-123 state register of medical products, 1996).

Lasermagnetic vessels subjected to irradiation of the blood flowing through the cubital Vienna left or right hand. The patient is in a supine position on the couch, his arms folded in the horizontal plane of the body at an angle thereto in the 90° and sits on the table inner surface upwards. Laser emitter establish contact, perpendicular to the arm and fixed in this position by a special tripod above the cubital vein, which is determined using a harness. The mode of emission of the laser pulse, the pulse frequency of 1500 Hz, the duration of the radiation pulse 100 NS. The exposure time in auto mode 7 minutes, the value of the power density of the radiation in the plane of the exit window of the applicator at normal temperature 8,93 mW/mm2. Magnetic induction in the plane of the window - 50 MT. Course of 5 treatments daily from the second day of the patient's stay at the resort the next 5 treatments a day, just 10. Table 1 presents the scheme of leave procedures of the proposed method.

Table 1
The scheme of leave procedures proposed method
Day treatmentSessions BOSLasermagnetic vessels blood irradiation (min)
Duration of sessions respiratory training-rest", minThe number of cyclesTime "training activities"Duration of procedure, min
Adaptation11; 3-1; 3-1; 3-139-413-
21; 3-1; 3-1; 3-139-4137
33-1; 3-1; 3-1; 3-1412-4167
43-1; 3-1; 3-1; 3-1412-4167
53-1; 3-1; 3-1; 3-1; 3-1515-5207
63-1; 3-1; 3-1; 3-1; 3-1515-5207
73-1; 3-1; 3-1; 3-1; 3-1515-520-
83-1; 3-1; -1; 3-1; 3-1515-5207
93-1; 3-1; 3-1; 3-1; 3-1515-520-
103-1; 3-1; 3-1; 3-1; 3-1515-5207
11-----
12---7
13-----
14----7
15-----
16----7

Example 1. Patient F., 49 years old, live in, Cheboksary. Was treated in the cardiology clinic with 18.05.02, 10.06.02, with a diagnosis of CHD. Angina, functional class I, a chronic heart condition is the first failure I functional class (NYHA). Hypertension stage III, grade 1, the risk is very high. Obesity II Art.

Upon receipt complained of intermittent compressive pain in the heart area, generated by significant physical exertion, radiating to the left subscapularis region, intractable nitroglycerin; shortness of breath when climbing over 4 floors of stairs, periodic headache increased blood pressure, insomnia, increased irritability, fatigue, pain in the lumbar spine.

The objective of the study at the time of admission: a proper physique, high power, weight 84 kg with height 168 cm Border of the heart is within normal limits, pulse 100 beats./min, rhythmic, satisfactory qualities. Heart sounds rhythmic, loud. AD=150/100 mm Hg (D=S). In the lungs vesicular breathing, wheezing no. The abdomen is soft, painless, the liver is not enlarged. Symptom tapping negative on both sides. In the Romberg sustainable, coordinating sample performs correctly. Palpation of the paravertebral points in the lumbar spine - pain.

These additional studies:

Complete blood count: Hb - 173,8 g/l, er. - 5,8×1012/l L - 6,0×109/l, ESR - 2 mm/hour, p - 2%, 48%, e - 2%, m - 6%, l - 42%. Reaction adjustment reaction high is ctively (Phharmacy).

Reactive anxiety - 18 points (low), personal anxiety - 37 points (moderate) on the Spielberg-Hanina (1980).

ECG sinus rhythm, 81 beats./min, the horizontal position of the electrical axis of the heart, incomplete blockade of the right leg phisa, overload and myocardial hypertrophy left atrial hypertrophy of the myocardium of the left ventricle, diffuse-degenerative changes in the myocardium prednamerennoe and anterolateral walls of the left ventricle.

VEM - tolerance to physical load is high, the achieved capacity - 141 W (TFN - 163 W). The sample is negative (signs of CHD are not registered). Hypertensive reactions of the cardiovascular system to physical activity.

Biochemical blood test: triglycerides - to 2.85 mmol/l (normal range of 0.59-1.77 mmol/l), total cholesterol of 6.5 mmol/l (normal 3,9-6,37 mmol/l)HDL cholesterol (PI) - 1.09 mmol/l (normal range of 1.01 to 1.9 mmol/l), atherogenic index is equal to 4.97 (norm 2,6-2,9), LDL - 9.4 g/l (normal 2,94-5,42 g/l), diene conjugates of lipids and 3.72% (rate of 1.06-2.06 to unit), malonic dialdehyde erythrocyte - 44,94 nmol/ml er. mass (rate of 35.6-to 43.4 mmol/ml er. mass), malonic dialdehyde lipid - 11,83 nmol/mg of lipids (norm 8,05-8,65 nmol/mg lipid), catalase serum - 32.1 ákat/l (normal range of 10.6-23.0 µkat/l)ceruloplasmin - 0,271 g/l (normal 0,300-0,380 g/l), fibrinogen - 3.0 g/l (normal range 2,0-4,0 g/l), kaolinovo time - 50 sec (normal 50-70 sec), tolerant the efficiency of the plasma to the heparin - 10 minutes (normal 10-16 min), fibrinolytic activity of plasma - 210 min (norm 183-263 min).

The adaptation period was calm, and remained elevated blood pressure. From the first day of stay in hospital the patient received sessions of biofeedback training daily for a course of 10 treatments. From the second day of stay in hospital was conducted lasermagnetic vessels blood irradiation, the duration of 7 minutes, the first five procedures a day, the next day after only 10 treatments (see table 1).

By the fifth day of stay in hospital were headaches, decreased irritability, fatigue, improved sleep. By the middle of the treatment stopped the pain in the heart area, normalized sleep, became more calm, active, blood pressure normalized - 120/80 mm Hg By the end of treatment, the body weight decreased by 4 kg

When conducting follow-up examination following data were obtained:

Complete blood count: Hb - 149,6 g/l, er. - 5,0×1012/l, L. - 8,3×109/l, ESR - 3 mm/h, p/I - 1%with/I - 48%e - 2%, m 10%, l - 39%. The response of the adaptive response of increased activation (Phharmacy).

Reactive anxiety - 12 points (low), personal anxiety - 23 points (low) on the Spielberg-Hanina (1980).

ECG sinus rhythm, 69 beats./min, the horizontal position of the electrical axis of the heart, napolnyaya right leg phisa, decreased overload of the myocardium of the left atrium and diffuse-degenerative changes in the myocardium prednamerennoe and anterolateral walls of the left ventricle.

VEM is the increased tolerance to physical activity, achieved power - 150 watts (163 W), which is 6.4% more compared with the original data, the sample is negative, hypertensive reactions of the cardiovascular system to load.

Biochemical blood test: triglycerides to 1.47 mmol/l, total cholesterol - 6,17 mmol/l, HDL cholesterol - 1.11 mmol/l, the index of atherogenic - 4,56, LDL - 6.8 g/l, diene conjugates of lipid - 4,04%, malonic dialdehyde red - 44,15 nmol/ml er. mass, malonic dialdehyde lipids to 7.75 nmol/mg lipid, serum catalase - 30.8 µkat/l ceruloplasmin - 0,357 g/l, fibrinogen - 3.11 g/l, kaolinovo time - 60 sec, the tolerance of the plasma to the heparin - 12 min, fibrinolytic activity of plasma - 210 minutes

Thus, the proposed method has allowed to increase the physical capacity of 6.4%; contributed to the demise of stenokardicheskie pain, shortness of breath, neurasthenic complaints (improved sleep, reduced fatigue, irritability, mild headaches), reduction of anxiety level to low values (Spielberg-Janino); normalize blood pressure; positive dynamics of ECG; stabilization reactions and is aptly. It was noted influence on plasma lipid profile: reduction of atherogenic fractions of lipids - triglycerides 48.4%, total cholesterol by 5.2%, LDL cholesterol by 27.7%, atherogenic index 8.3%; increased atherogenic potential of the plasma is increased HDL cholesterol was 1.8%. Dynamics of indicators of lipid peroxidation ambiguous: the primary products of the degradation of lipid - diene conjugates of lipids is increased by 8.6%, while the content of secondary products of degradation - malondialdehyde erythrocytes and malondialdehyde lipid decreased by 1.8% and 34.5%, respectively, while increasing the activity of antioxidant enzymes - ceruloplasmin 31.7% and reduce the level of catalase by 4.1%. From coagulation activity of the blood parameters were changed within the range of normal values. Discharged with improvement.

Example 2. Patient A., 55 years old, live in PE-Ola. Was treated in the cardiology clinic with 10.06.02, 03.07.02, with a diagnosis of CHD. Angina functional class II, chronic heart failure functional class I (NYHA). Hypertension stage III, 3 degree, the risk is very high. III degree obesity.

Upon receipt complained of intermittent pressing pain in region of heart for two years, occurring against a background of moderate physical is their and emotional stress, radiating to the left arm, accompanied by a feeling of lack of air, with the effect of nitroglycerin with validol, shortness of breath when climbing on the 4th floor, fatigue, insomnia, memory loss on current events and headaches. Arterial hypertension for 8 years, episodic receiving antihypertensive drugs.

The objective of the study at the time of admission: a proper physique, high power, weight 78 kg with height 152 see the Border of the heart is extended to the left by 1 cm, heart sounds, rhythmic, muted, accent II tone of the aorta, the pulse - 69 beats./min, rhythmic, satisfactory quality. AD=160/100 mm Hg (D=S). In the lungs - vesicular breathing, wheezing is not heard. The abdomen is soft, painless, the liver is not enlarged. Symptom tapping negative on both sides. Emotionally labile. In the Romberg sustainable, coordinating sample performs correctly.

These additional studies:

Complete blood count: Hb - 153,6 g/l, er. - 5,0×1012/l, l - 5,5×109/l, ESR - 8 mm/h, p/I - 2%, with/I - 46%e - 1%, m - 7%, l - 44%. Response adaptation - enhanced activation (Garkavi LH).

Reactive anxiety - 38 points (moderate), personal anxiety - 42 points (moderate) on the Spielberg-Hanina (1980).

ECG sinus rhythm, 85 beats./min, the normal position of the electrical axis is Enza, myocardial hypertrophy of the left atrium and the left ventricle.

VEM - tolerance to physical load is low, the achieved capacity is 33 watts (should - 97 W), registered clinical signs of ischemic heart disease, hypertensive reactions of the cardiovascular system to physical activity.

Biochemical blood test: triglycerides - of 1.26 mmol/l (normal range of 0.59-1.77 mmol/l), total cholesterol - 4,51 mmol/l (normal 3,9-6,37 mmol/l)HDL cholesterol (PI) - 1.09 mmol/l (normal range of 1.01 to 1.9 mmol/l), atherogenic index - 3,14 (norm 2,6-2,9), LDL - 5,4 g/l (normal 2,94-5,42 g/l), diene conjugates of lipid - 1,67% (rate of 1.06-2.06 to unit), malonic dialdehyde erythrocyte - with 52.0 mmol/ml er. mass (rate of 35.6-to 43.4 mmol/ml er. mass), malonic dialdehyde lipids and 10.8 nmol/mg of lipids (norm 8,05-8,65 nmol/mg lipid), catalase serum - 40.3 ákat/l (normal range of 10.6-23.0 µkat/l)ceruloplasmin - 0,289 g/l (normal 0,300-0,380 g/l), fibrinogen - 4.11 g/l (normal range 2,0-4,0 g/l), kaolinovo time - 50 sec (normal 50-70 sec), the tolerance of the plasma to the heparin - 15 min (norm 10-16 min), fibrinolytic activity of plasma - 270 min (norm 183-263 min). Increased levels of atherogenic index, fibrinogen, activation of processes of lipid peroxidation, impaired antioxidant defense system.

The adaptation period was calm. From the first day of stay in hospital the patient received sessions of biofeedback training daily for a course of 10 treatments. Since W is the second day of stay in hospital was conducted lasermagnetic vessels blood irradiation duration 7 min, the first five treatments a day, the next day after only 10 treatments (table 1). On the seventh day stay patient at the clinic has reduced the frequency of angina attacks, normalized blood pressure numbers 130/80 mm rst, improved sleep. By the end of the second week of treatment stopped the pain in the heart, shortness of breath have decreased, disappeared neurotic complaints, headache, normalized sleep. By the end of treatment, the body weight decreased by 2 kg

At follow-up, the following data:

Complete blood count: Hb - 137,8 g/l, er. - 5,1×1012/l, l - 4,8×109/l, ESR - 7 mm/h, p/I - 1%with/I - 51%, e - 2%, m - 9%, l - 37%. The response of the adaptive response of increased activation (Phharmacy).

Reactive anxiety - 14 points (low), personal anxiety - 16 points (low) on the Spielberg-Hanina (1980).

ECG sinus rhythm, 69 beats./min, the speakers are not marked.

VEM is the increased tolerance to physical activity, achieved capacity - 58 W (97 W), which by 25.8% compared with the original data. Registered clinical signs of CHD, normostenichesky type of reaction of the cardiovascular system to load.

Biochemical blood test: triglycerides - 1.77 mmol/l, total cholesterol - to 5.03 mmol/l, HDL cholesterol - 1.06 mmol/l, the index of atherogenic -3,75, LDL - 4.6 g/l, diene conjugates of lipids to 3.02%, malonic dialdehyde red - 38,63 nmol/ml er. mass, malonic dialdehyde lipid - 7,88 nmol/mg lipid, serum catalase - 22.1 µkat/l ceruloplasmin - of 0.333 g/l, fibrinogen - 3,55 g/l, kaolinovo time - 60 sec, the tolerance of the plasma to the heparin - 10 min, fibrinolytic activity of plasma - 240 minutes

Thus, the proposed method has allowed to improve physical performance by 25.8%; contributed to the regression stenokardicheskie pain, shortness of breath; reduction neurasthenic complaints (improved sleep, reduced fatigue, mild headaches), reduction of anxiety level to low values (Spielberg-Janino); normalize blood pressure; stabilization reactions adaptation. There was no effect on plasma lipid profile. Dynamics of indicators of lipid peroxidation ambiguous: the primary products of the degradation of lipid - diene conjugates of lipids is increased to 80.8%, whereas the content of secondary products of degradation - malondialdehyde erythrocytes and malondialdehyde lipid decreased by 25.7% and 27.0%, respectively, against the background of increasing the activity of antioxidant enzymes - ceruloplasmin by 15.2%, to normalize the level of catalase. There was a decrease clotting activity of the blood - decreased fibrinogen level of 15.5% and an increase anticoagulation on the potential - the level of fibrinolytic activity in plasma by 12.5%. Discharged with significant improvement.

Just surveyed and treated 110 patients in the two groups.

Group I - 58 patients received treatment by the proposed method - patients with ischemic heart disease (120.8, ICD-X), angina I-II functional classes (Canadian classification of cardiology, without rhythm disturbances with chronic heart failure not more than II FC (NYHA), with risk factors - hypertension, dyslipidemia, psycho-emotional stress, overweight, impaired reactions of adaptation.

Group II - 52 patients with coronary artery disease (120.8, ICD-X), angina I-II functional classes (Canadian classification of cardiology, without rhythm disturbances with chronic heart failure not more than II FC (NYHA), with risk factors - hypertension, dyslipoproteinemia, psychological stress, disturbance reactions adaptation - received treatment on the prototype.

The most frequent subjective manifestations of disease in both groups had pain in the heart area compressive or whining character with irradiation to the left arm, below the shoulder blade arising from physical or emotional stress, palpitations, shortness of breath during exercise. In addition, almost all patients had expressed the various degrees of sleep disturbance, irritability, fatigue, unexplained feelings of fear, anxiety and clinically significant comorbidities internal organs.

In the analysis of subjective symptoms during treatment were observed improvement in all groups observed patients. When the one-way dynamics of the subjective state in the first group there was a marked analgesic effect: relieving pain in the heart, reducing heart rate, headaches in the middle of the treatment; observed and a clear anxiolytic effect disappeared irritability, fatigue, sleep disturbance to a 7-10 day stay in the clinic. In group II, the positive effect was observed only at the end of treatment.

According to table 2, we observed a rather high efficiency of treatment in group I patients who took the treatment by the proposed method compared with group II: there is a more significant reduction in complaints coronary pain, palpitations, sleep disturbances, dominated by the percentage of improvement.

CHD patients was conducted by questionnaire method of determining the level of anxiety on a scale of personal and situational anxiety Cdecember modification Uljanin (1980). Before treatment revealed a high level of personal anxiety and the average level of situational anxiety in all patients with ischemic heart disease in the quantitative assessment of the EC questionnaire Spielberg Hanina, that characterized patients with high stress orientation and chronic psycho-emotional stress.

Table 2
The dynamics of the complaints according to the subjective symptoms of patients with coronary heart disease under the influence of complex treatment (%)
GroupStenokardicheskie painShortness of breathIrritabilityInsomniaHeadachePalpitationsFatigue
ToΔtoΔto×to×toΔtoΔtoΔ
PEFCPEFCPEFCPEFCPEFCPEFCPEFC
Ifor 91.3-69,669,6-1,830,4-21,726,1-26,1 69,6-65,334,8-26,147,8-34,8
21,747,88,704,38,713,0
II92,4-63,857,3- 15.2 m40,928,7-12,232,612,4-20,258,6-48,128,8-19,336,5-26,5
28,642,110,59,610,0
Note. Δ - change indicators in the treatment process

After the complex treatment of test data Spielberg Hanina stated that the greatest decrease in the level of anxiety occurred in group I, reflecting the General trend of the reduction of trait anxiety to "medium" level of 35.1 points (p<0.001) and situational anxiety to "low" values - 18.7 points (p<0,01). These data showed a decrease in emotional distress and increase adaptive reactions of the personality to the action of stress factors. It should be noted that the medical complex has a non-specific modulatory effects on psi the practical sphere, causing emotional or personality changes due to the acquisition and use of skills of relaxation and slow diaphragmatic breathing. In group II the observed patients, those declines are somewhat less pronounced (up to 39.4 25.2 points) (table 3).

Table 3
Indicators of levels of anxiety in patients with coronary artery disease survey by Spielberg-Janino
IndicatorsI groupGroup II
Index of reactive anxiety
Index of personal anxiety
Notes. The numerator is the value of the index before treatment, the denominator is the value of the index after treatment; ** - significance of differences p<0,001

Adaptive reactions were studied by Phharmacy (the ratio of lymphocytes to segmental neutrophils) and assessed the value of this indicator (table 4).

Table 4Dynamics of adaptive reactions in CHD patients during treatment (%)Adaptation reactionsI groupGroup IIBefore the treatmentAfter the treatmentΔBefore the treatmentAfter the treatmentΔStress00 00 The reaction increased activation56,594,7+38,254,462,0+7,6The calm reaction activation43,50-43,541,830,4-11,4Reaction training05,3+5,3the 3.87,6+3,8Note. Δ - change indicators in the treatment process

In group I patients after treatment by the proposed method increased the number of patients with the most favorable responses increased activation by reducing the number of patients with reactions peaceful activation and indifferent reactions Tr is miravci, indicating a mobilization of the compensatory capacity of patients with coronary artery disease.

In group II, the number of patients with reactions increased activation increased slightly, at the same time slightly increased the number of patients with indifferent reactions to training (table 4).

When analyzing the indices of cardiorespiratory system in IHD patients in the treatment method of biofeedback noted (table 5) reducing both systolic and diastolic blood pressure directly on the procedures and process of treatment to 10 session (p<0,001). Reducing HELL happened gradually from session to session with stabilization by the end of treatment, indicating the adaptive effect of the treatment. Respiratory arrhythmia of the heart by the end of the treatment significantly increased 33.7% (p<0,001), suggesting a dominant effect vagotomies regulation of the autonomic nervous system directly on the session due to a given frequency breathing with biofeedback training. Thus, reducing heart rate, GARDEN, dad, increasing the DAS indicates an improvement in autonomic security of the cardiovascular system coronary patients.

Table 5
Changing hemodynamic parameters in sick the CHD, angina (120.8, ICD-X) associated with essential hypertension (110.0, ICD-X) at the sessions of biofeedback
The sessionHR beats./minDAS beats./minBH minGARDEN mm HgDBP mmHg
toaftertoaftertoaftertoaftertoafter
1M68,2469,099,599,726,035,58154,3144,3102,587,5
±mof 1.571,610,680,890,410,482,973,692,506,29
t1,660,27of 1.342,12,2
t*0,080,442,380,40,7
5 M68,3667,499,949,855,154,82146,0136,090,080,0
±m1,41of 1.340,810,70,330,392,455,092,404,80
t1,950,211,510,723,7
t**0,040,972,990,20
10M67,766,5712,0412,694,14a 3.9135,0127,085,080,0
±m1,681,610,80,220,265,007,002,804,20
t1,910,541,070,93a 3.9
t*** 0,252,044,075,24,59
Notes: t is the difference between metrics directly on the session;
t* is the difference of performance between the first and fifth sessions;
t** is the difference of performance between the fifth and tenth sessions;
t*** - the difference in performance between the first and tenth sessions.

Analysis of lipid metabolism observed in patients showed that all patients baseline were above normal (table 6), indicating that the severity of this risk factor for CHD, as hyperlipoproteinemia, and hence the atherosclerotic process. The marked increase in the concentration of triglycerides, total cholesterol, cholesterol of low density lipoproteins and atherogenic index.

Under the influence of the treatment by the proposed method in patients (group I) showed a significant, statistically significant reduction in total cholesterol, atherogenic index, increased cholesterol high density lipoprotein. The remaining indicators tended to normalize (table 6). In patients of group II marked a significant decrease in the atherogenic. The tendency is to normalize the other indicators are less pronounced, than in patients of the first group.

1,28
Table 6
Dynamics of lipid metabolism in patients with ischemic heart disease in the two groups
GroupStat. indexTriglycerides, mmol/lTotal cholesterol, mmol/lHDL cholesterol, mmol/lThe atherogenic index, %LDL cholesterol, g/l
IM±m
t1,361,702,002,001,64
IIM±m
t0,841,632,321,28
HealthyM±m1,18±0,115,20±0,211,46±0,082,75±0,134,16±0,22
Note. In the numerator indices before treatment, in the denominator - after treatment

Under the influence of treatment in CHD patients who took the treatment by the proposed method (group I), significantly decreased the level of malondialdehyde MDA in erythrocyte mass and lipids in trend towards increased diene conjugates (DC), indicators of the processes of accumulation in the body products of lipid peroxidation.

Catalase is an enzyme, reflecting the activity of the antioxidant defense system, the source was increased in CHD patients with a significant reduction of another enzyme ceruloplasmin. After treatment in group I significantly increased the content of ceruloplasmin to normal values. The content of catalase remained almost unchanged (table 7).

Table 7
Indicators of lipid peroxidation and antioxidant protection b is selected CHD two groups
GroupStat. indexIndicators of lipid peroxidationIndices of antioxidant system
Diene conjugatesHMM, mmol/ml armacyMDA, n/mol/mg LPS.Catalase, µkat/lTorulopsis, min g/l
IM±m
t0,521,853,610,392,30
IIM±m
t0,90,41,60,041,6
HealthyM±m1,56±0,1439,5±0,928,35±0,0816,8±1,590,340±0,009
Note. In the numerator indices before treatment, in the denominator - after treatment.

Thus, the analysis of lipid metabolism, lipid peroxidation, antioxidant defense system have shown that the most effective is complex, including biofeedback method with extravascular laser irradiation of blood, which is pathognomonic for such a risk factor for CHD, as a violation of lipoproteina metabolism. Biochemical changes clotting and fibrinolytic properties of blood cause the formation of thrombosis and determine their significance as a risk factor of coronary heart disease and the need for correction. We observed CHD patients in the initial state noted the increase in the content of fibrinogen, decreased tolerance to heparin plasma, a significant reduction in fibrinolytic activity of plasma (table 8).

Treatment of patients with coronary heart disease under the proposed method (group I) contributed to the improvement of the blood coagulation system: reduction of fibrinogen by 22.7% (p<0,001), increased tolerance to heparin plasma 184% (p<0,001), kaolinovogo time by 30.6% (p<0,001), a significant increase in fibrinolytic activity of plasma 32.7% (p<0,001) - the anticoagulant capacity of blood, which is especially important for multifactorial prevention of coronary heart disease (table 8).

Table 8
The performance of the coagulation system in patients with ischemic heart disease in the complex treatment
GroupStat. indexFibrinogen, g/lKalinovo time, secTolerance to heparin plasma, minFibrinolytic activity, min
IM±m
t5,2of 5.45,04,1
IIM±m
t1,194,800,31
HealthyThe range of fluctuations2,0-4,050-7010-16183-263

In group II patients changes of the coagulation properties of blood less pronounced.

Thus, combined treatment has a corrective effect on hemostasis in patients with coronary artery disease: nijaat coagulating activity and improves fibrinolytic properties of blood. A powerful activator of anticoagulant, in particular fibrinolytic, activity is extravascular laser effect on blood on the background barefoot.

The comparative evaluation of the effectiveness of treatment (table 9) on the proposed method using biofeedback and extravascular laser irradiation of blood (group I) and biofeedback (group II) showed a fairly high percentage of improvement in group I (97.1 per cent) compared with group II (91,2%) (p<0,001).

Table 9
The overall efficiency of the complex Spa treatment of patients with ischemic heart disease (%)
GroupThe results of the treatmentPoints
significant improvementimprovementa slight improvementwithout changedeteriorationt
I10,265,221,72,904,36±0,132,82
II4,358,528,48,803,88±0,12

When evaluating the effectiveness should be taken into account and the timing of its occurrence: subjective improvement of symptomatic and, ECG data-indicators, reactions adaptation and emotional stability is marked by the middle of treatment to the 5th treatment-resistant stabilization to the 10th procedure, while the prototype of the number of sessions to achieve the effect - 12. The effect lasts for 8.3 months without exacerbation of the main disease and without severe reactions to personal and situational anxiety in IHD patients in response to a stressful situation.

A method of treating coronary heart disease, strokes voltage I-II functional classes, including magnetic effect by irradiation of the cubital vein pulsed laser radiation, which is conducted from the second day of treatment, a course of 10 treatments with a duration of 7 minutes, with the first five procedures performed daily, follow-through day, characterized in that the power density of the laser radiation is 8,93 mW/mm2, magnetic induction - 50 MT, with the first day of treatment daily breathing exercises with development of diaphragmatic breathing through training, in which the patient makes inhaling through the nose of active movement of the anterior abdominal wall of the abdomen, and when breathing out through closed lips belly pulls in, the breathing frequency is 3-5-7 in 1 min, the duration of the session 13-20 minutes



 

Same patents:

FIELD: medicine, urology.

SUBSTANCE: one should affect with light-diode radiation, magnetic field rectally onto prostatic projection, carry out micro-enemas of magnetized mineral water, magnetotherapy onto areas of pubis, sacrum and perineum. In case of chronic prostatitis in case of exacerbation one should affect with blue, infrared radiation and magnetic field. In case of chronic prostatitis at the stage of remission - with blue, infrared radiation and magnetic field during the first 3-4 procedures, and then - with red, infrared radiation and magnetic field during the next 5-8 procedures, daily, about 8-12 procedures/course. The method enables to carry out differentiated treatment of chronic prostatitis depending upon the activity of inflammatory process and decrease manifestation of pathological side reactions.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine.

SUBSTANCE: invention proposes a method for inhibition of chorionic neovascularization. Method involves irradiation of undesirable novel vascular reticulum in combination with photosensitive agent (porphyrine) and an anti-angiogenic agent taken among antagonist of phospholipase A2, inhibitor of complex kappa B, inhibitor of the growth hormone, inhibitor of insulin-like growth factor-1, inhibitor of cyclooxygenase II, inhibitor of protein kinase C (stautosporin PKC 412) and inhibitor of angiotensin II. The claimed combined treatment provides potentiation of effect of adjunctive photodynamic therapy in combination with enhanced safety.

EFFECT: improved treatment method.

7 cl

FIELD: medicine.

SUBSTANCE: method involves modeling cystic process by introducing 0.1% Synestrol solution in oil once a week during 35 days and exposing mammary gland to helium-neon laser radiation with wavelength of 633 nm and light guide exit power of 13 mW within 10 min during 8 weeks.

EFFECT: enhanced effectiveness in correcting and treating cystic processes in experimental animal mammary gland.

8 dwg

FIELD: medicine; ophthalmology.

SUBSTANCE: method can be used for treatment of serious deep keratitis. Infiltration of cornea is subject to laser IR thermal therapy at wavelength of 810 nm, radiation power of 1000-1250 mW, diameter of spot in focal plane of 2 to 3 mm, time of exposure is 3 sec. 1 to 3 procedures are carried out with time interval of 3-7 days. Method allows avoiding expressed post-operational astigmatism, coagulating effect and development of deep keratoleukoma.

EFFECT: improved efficiency of treatment.

1 ex

FIELD: medicine.

SUBSTANCE: method involves treating intact tissues adjacent to wound or ulcerative defect and regional neurovascular fascicle projections with defocused laser beam of 1-10 W large power via light guide moving at a rate of 0.5-2.0 cm/s. Wound or ulcerative defect surface is remotely treated in moving light guide at a rate of 1-10 mm/s from periphery to the center scanning the surface in circular or linear mode with laser radiation of 1-10 W power. High intensity laser radiation is used as the laser radiation attached to wavelength of 0.805-1.064 mcm in continuous and pulsating mode.

EFFECT: enhanced effectiveness in stimulating additional biologically active zones and improving blood circulation condition therein; accelerated marginal epithelialization process.

2 cl

FIELD: medicine, surgery.

SUBSTANCE: after sanitation one should once inject intravenously 0.04%-sodium hypochlorite solution at 10 ml/kg body weight and then - repeatedly in about 10-12 h at the same dosage; then in about 10-12 h twice and in 36 h it is necessary to perform intravenous laser blood irradiation with a He-Ne laser at the dosage of 2 mW at exposure of 5 min. The innovation enables to normalize the quantity of erythrocytes, thrombocytes and leukocytes, provides complete restoration of phagocytic and digestive capacity of neutrophilic granulocytes that, in its turn, enables to interrupt syndrome of endogenic intoxication in earlier terms.

EFFECT: higher efficiency of therapy.

1 cl, 2 ex

FIELD: medicine.

SUBSTANCE: method involves acting with electric current of ultrasonic frequency upon eyes projections with power of 1-2 kW within 3 min on each field. Then, pulsating infrared laser radiation treatment is applied to cerebral cortex vision zone projections with power of 5 mW, frequency of 8-12 Hz within 3 min on one field. The total treatment course is 5-10 daily procedures long.

EFFECT: enhanced effectiveness in normalizing intraocular blood pressure; accelerated rehabilitation process.

FIELD: medicine.

SUBSTANCE: method involves applying photosensitizing glue based on hyaluronic acid viscoelastic selected from a group composed of Healon, Viscoat and Hyatulon. Gel has 0.1-2% by mass of chlorine row photosensitizer selected from a group composed of Photolon, Radachlorine and Photodithazine or 0.1-1% by mass of porphyrin row photosensitizer selected from a group composed of Photogem and Photophrin. After photosensitizing glue, covering cornea wound, being kept away from light within 30-60 min, the cornea wound exposed to laser radiation as a series of applications with 5% overlay on neighboring flash exposure spots arranged done in circle first along outer ulcer contour and finishing in the ulcer center. Irradiation power density is gradually reduced from 60-80 J/cm2 when irradiating ulcer periphery to 30-40 J/cm2 when irradiating ulcer center.

EFFECT: improved cornea wound healing and epithelialization; no repeated inflammation and ulcer perforation occurring.

FIELD: medicine.

SUBSTANCE: method involves degreasing pathologically transformed area with preparation containing no alcohol. Scanning pulsating laser radiation having wavelength of 800-930 nm and frequency of 140-160 Hz is applied for 5-20 min under radiation power of 4-10 W in pulse and its duration being equal to 50-300 Ns. Then, photosensitizing cream, gel or ointment containing chlorine row photosensitizer is applied. The photosensitizer is selected from a group containing Photolon, Radachlorine or Photodithazine in the amount of 0.1 to 2% or porphyrin row photosensitizer selected from a group containing Photogem or Photofrin in the amount of 0.1 to 1%. After having exposed pathologically transformed skin area away from light during 30-180 min, remaining photosensitizer residue is removed without injuring epidermis. The pathologically transformed skin area is insulated from intact skin with material impermeable for laser radiation. Its laser radiation is carried out with parallel light beam passed through square, triangular, rectangular, pentagonal or hexagonal shape stencil moving it edge-to-edge over the whole pathologically transformed skin area. Wavelength is equal to 661-666 nm when using chlorine row photosensitizer or 630-633 nm when using porphyrin row photosensitizer. Radiation power density is equal to 30-60 J/cm2. Not more than 100 cm2 of pathologically transformed skin area is treated in one photodynamic therapy session. Dermabrasion of the next pathologically transformed skin area is carried out after healing the preceding one.

EFFECT: accelerated epithelialization period; reduced risk of infectious complications; predictable cosmetic results.

3 cl

FIELD: medicine, surgery.

SUBSTANCE: one should perform endoscopic puncturing in affected area of esophageal mucosa in 4-10 points with a dispersed biological material named Alloplant. Moreover, biological material should be dissolved in 2%-lidocaine solution at the ratio of 5-15 g biomaterial/5-15 ml solution. For each points one should introduce per 0.5-2.0 ml solution, the affected area should be treated with low-intensive impact of laser radiation in red spectrum. Combination of Alloplant and energy of laser irradiation provides prolonged stimulation of local immunity and complete regeneration of surface epithelium.

EFFECT: higher efficiency for therapy and prophylaxis.

2 cl, 2 ex

FIELD: medicine, urology.

SUBSTANCE: one should affect with light-diode radiation, magnetic field rectally onto prostatic projection, carry out micro-enemas of magnetized mineral water, magnetotherapy onto areas of pubis, sacrum and perineum. In case of chronic prostatitis in case of exacerbation one should affect with blue, infrared radiation and magnetic field. In case of chronic prostatitis at the stage of remission - with blue, infrared radiation and magnetic field during the first 3-4 procedures, and then - with red, infrared radiation and magnetic field during the next 5-8 procedures, daily, about 8-12 procedures/course. The method enables to carry out differentiated treatment of chronic prostatitis depending upon the activity of inflammatory process and decrease manifestation of pathological side reactions.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine.

SUBSTANCE: method involves rectally exposing prostate projection zone to red, infrared radiation, magnetic field and magnetic therapy is applied to sacral region, pubis and perineum. Magnetized sapropelic tampon is introduced into the rectum after applying combined rectal treatment. Tampon volume is equal to 140-160 ml and hold for 30-40 min under temperature of 37-38°C and magnetic therapy is applied to sacral region, pubis and perineum region.

EFFECT: wide range of therapeutic applications.

Medical applicator // 2269368

FIELD: medical engineering.

SUBSTANCE: device has metal casing having permanent magnet inside. Electrode is outside of the casing and connected to electric current source. The second electrode, manufactured from non-magnetic material having cavity, is inside of the casing. Permanent magnetic is mounted in the cavity. Substance like mineral solution or plant oil is placed between the electrodes. Dielectric bushing is mounted in the casing for insulating electrodes and substance from the casing. Electric current supply source is mounted with one of its contacts on the first electrode and with its second electrode having ironwork fault. One of applicator embodiments has spring placed between electric current supply source and casing. Another version has electrode mounted outside of the casing. It is manufactured from nonferrous metal having silver coating.

EFFECT: wide range of functional applications.

3 cl, 1 dwg

FIELD: medicine, surgery.

SUBSTANCE: the present innovation deals with operative interference followed by the impact with magnetolaser infrared radiation of 80 Hz frequency per 30 sec or 2-4 fields and with direct magnetic field at the value of magnetic induction being 25-50 mTl for 10-20 min successively. At first, one should affect postoperational area, the - reflexogenic area at one's foot, daily for 8-12 d. Since the 9th - 13th d one should affect with single direct magnetic field with the value of magnetic induction being 25-50 mTl for 10-20 min successively. At first, one should affect postoperational area, then - reflexogenic area at one's foot for 10 -12 d. The innovation decreases the frequency of postoperational complications.

EFFECT: shortened terms of therapy.

2 ex

FIELD: medical engineering.

SUBSTANCE: method involves acting in turn with ultrasonic and magnetic field with switch frequency of 10 to 160 Hz. Ultrasonic field intensity is set below cavitation threshold and ultrasonic oscillation frequency being equal to liquid acoustic relaxation frequency. Magnetic field induction being selected within the limits of 30-50 mTesla units.

EFFECT: enhanced effectiveness of liquid activation; reduced power consumption.

1 dwg

FIELD: medicine.

SUBSTANCE: method involves carrying out vitrectomy with posterior hyaline membrane being removed. Retinotomy is carried out with subretinal neovascular complex being removed. Autogenous pigment retinal epithelium is subretinally introduced through retinotomy area as stratum or suspension. The intravitreous tamponade is carried out with perfluororganic compound substituted with air next to it. Flexible polymer magnetolaser implant having ring-shaped magnet with axial permanent magnetic field magnetization of 3-7 mTesla units is extrasclerally mounted into tunnel built between sclera and Tenon's capsule in macular area projection zone. The implant is turned with S pole towards transplanted cells so that laser radiation-emitting lens is arranged in their projection zone. Implant light guide is sutured to sclera 5-6 mm far from limb. The implant is covered with conjunctiva. Light guide outlet is attached to temple. The introduced cells are treated via laser light guide and implant lens with divergent continuous laser radiation. The magnetic implant is removed after having finished the treatment course and sutures are placed on conjunctiva.

EFFECT: enhanced effectiveness of treatment.

FIELD: medicine.

SUBSTANCE: method involves carrying out transpupillary laser coagulation of central avascular zones and transscleral cryocoagulation of peripheral avascular retina zones. 3-4 mm long incisions in conjunctiva and Tenon's capsule are done between sclera and Tenon's capsule in perpendicular to limbus 3-4 mm far from it. Tunnel is built in projection zone of an avascular retina zone between sclera and Tenon's capsule in parallel to the limbus on both sides of the incision. Flexible polymer magnetic implant is extrasclerally introduced into the tunnel in projection zone of an avascular retina zone. The implant has its own permanent magnetic field with magnetic poles alternating on each of sides and permanent magnetic field intensity of 0.5-1.0 mTesla units. The implant is sutured with one of its ends to sclera, and suture is placed on conjunctiva, and anti-oxidant therapy is applied. Magnetic stimulation therapy course is applied 3-4 weeks later. The course combines actions of permanent magnetic field produced by extrasclerally arranged magnetic implant and external rotating permanent magnetic field of 0.30-0.40 mTesla units intensity. Periodicity of external magnetic field action is selected to be 1-2 times per day with external action duration being equal to 3-5 min per 1 session during 10 days. The extrasclerally arranged flexible polymer magnetic implant is removed when treatment course is over. The flexible polymer magnetic implant is manufactured from biologically stable polymer material like one on polypropylene, polyester or polyethylene basis having permanent magnet material powder particles uniformly distributed therein. Magnetic material particles are of samarium-cobalt, neodymium-iron-boron or samarium-iron-nitrogen base.

EFFECT: enhanced effectiveness of prophylactic treatment; prevented severe disease forms progress; released retina edema.

6 cl

FIELD: medicine.

SUBSTANCE: method involves carrying out transpupillary laser avascular zones coagulation. Taurin is dropped into conjunctival cavity at a dose of 1-2 drops into the eye under treatment 5-6 times a day during 7-10 days. 0.02% Histochrome solution is dropped into conjunctival cavity at a dose of 2 drops into the eye under treatment 5-6 times a day during 7-10 days. 0.02% Histochrome solution or 0.02% Emoxipin solution or 1% Retinalamine solution in the amount of 0.4-0.6 ml once a day is parabulbary introduced as antioxidant during 7-10 days. Magnetic stimulation course is applied on the background of conservative therapy to orbital or temporal head region of prematurely born child in any succession using external rotating permanent magnetic field of 0.15-0.40 mTesla units intensity. Periodicity of external magnetic field action is selected to be 1-2 times per day with external action duration being equal to 3-5 min per 1 session during 10 days with magnetic field being 15-30 cm far from orbital or temporal head region of prematurely born child. External permanent magnetic field rotating at constant or variable speed is applied for carrying out magnetic stimulation treatment. Repeated conservative therapy and magnetic stimulation treatment with external rotating permanent magnetic field is additionally applied in 1-3 months. The number of repeated courses is equal to 1-3.

EFFECT: enhanced effectiveness of prophylactic treatment; prevented severe disease forms progress; released retina edema; improved blood circulation in avascular zones.

3 cl

FIELD: medicine.

SUBSTANCE: method involves building tunnel to posterior eyeball pole in inferoexterior and superexterior quadrants. The tunnel is used for implanting flexible polymer magnetolaser implant to the place, the subretinal neovascular membrane is localized. The implant has a permanent magnet shaped as a cut ring and is provided with drug delivery system and a short focus scattering lens of laser radiator connected to light guide. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 5-7 mTesla units intensity. It is arranged with its north pole turned towards sclera at the place of the subretinal neovascular membrane projection with extrascleral arrangement of laser radiator lens membrane being provided in the subretinal neovascular membrane projection area. The other implant end is sutured to sclera 5-6 mm far from the limb via holes made in advance. The implant is covered with conjunctiva and retention sutures are placed thereon. Light guide and drug supply system lead is attached to temple with any known method applied. Drugs are supplied via the implant drug supply system in retrobulbary way in any order. Triombrast is given in the amount of 0,4-0,6 ml and dexamethasone or dexone in the amount of 0,4-0,6 ml during 3-4 days every 12 h. 0.1-1% aqueous solution of khlorin is intravenously introduced at the third-fourth day after setting the implant as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, at a bolus dose of 0.8-1.1 mg/kg. Visual control of subretinal neovascular membrane cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the subretinal neovascular membrane with the photosensitizer to maximum saturation level, intravitreous, transretinal laser radiation of 661-666 nm large wavelength is applied at general dose of 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the subretinal neovascular membrane via laser light guide and implant lens, repeated laser irradiation of the subretinal neovascular membrane is carried out with radiation dose of 30-60 J/cm2.

EFFECT: accelerated subretinal edema and hemorrhages resorption; regression and obliteration of the subretinal neovascular membrane; prolonged vision function stabilization.

6 cl

FIELD: medicine.

SUBSTANCE: method involves creating tunnel between sclera and Tenon's capsule in intraocular neoplasm projection. Intraocular neoplasm localization and size is adjusted by applying transscleral diaphanoscopic examination method. 0.1-0.3 ml of photosensitizing gel based on viscoelastic of hyaluronic acid, selected from group containing chealon, viscoate or hyatulon, is transsclerally introduced into intraocular neoplasm structure using special purpose needle in dosed manner. The photosensitizing gel contains khlorin, selected from group containing photolon, radachlorine or photoditazine in the amount of 0.1-1% by mass. Flexible polymer magnetolaser implant is extrasclerally introduced into the built tunnel in intraocular neoplasm projection zone under visual control using guidance beam. The implant has permanent ring-shaped magnet axially magnetized and producing permanent magnetic field of 3-4 mTesla units intensity, in the center of which a short focus scattering lens of laser radiator is fixed. The lens is connected to light guide in soft flexible envelope. The implant is arranged with its north pole turned towards the intraocular neoplasm so that implant laser radiator lens is extrasclerally arranged in intraocular neoplasm projection zone. The implant light guide is sutured to sclera 5-6 mm far from the limb with single interrupted suture. The implant is covered with conjunctiva and relaxation sutures are placed over it. Light guide outlet is attached to temple using any known method. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, transscleral intraocular neoplasm laser radiation treatment is carried out via laser light guide and implant lens using divergent laser radiation at wavelength of 661-666 nm. The treatment course being over, the flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, neodymium-iron-boron or samarium-iron-nitrogen. 0.1-1% khlorin solution as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is additionally intravenously introduced in 2-3 days at a dose of 0.8-1.1 mg/kg and repeated laser irradiation of the intraocular neoplasm is carried out with radiation dose of 30-45 J/cm2 15-20 min later during 30-90 s.

EFFECT: complete destruction of neoplasm; excluded its further growth.

4 cl

FIELD: medicine, in particular, sanitation physical culture.

SUBSTANCE: method involves teaching patient to breathing-muscular procedure including sequential straining of hand, forearm, and shoulder muscles in synchronism with inhalation and relaxation thereof in reverse sequence in synchronism with expiration, and in the same manner - of lower limb and body muscles; causing patient to familiarize himself with feeling of movable muscle tension or relaxation - breathing muscular wave; during exercising, teaching to produce breathing muscular wave of different directivity, rhythm and expressiveness; providing correction of organism's functional state by placing patient's hands onto investing tissues in projection of organ; pressing for fixing organ and providing rhythmical motions of knees to the right, to the left while drawing pelvis and abdomen into motion; performing bending and unbending body motions in sitting, standing and lying positions, with deep breathing with different kinds of breathing-muscular wave being used during performing of bending and unbending motions.

EFFECT: increased efficiency owing to acting upon different levels of metameric-receptor field of internal organs.

1 ex

Up!