Method for treatment of cattle intoxicated with cynoglossum

FIELD: medicine, in particular veterinary.

SUBSTANCE: invention relates to method for treatment of cattle intoxicated with Cynoglossum officinalis containing in feed hey as admixture. Claimed method includes administration perorally of sorbent, namely healthy feed supplement containing in dose of aluminum silicate in dose of 0.15 g/kg of body mass; saccharose in dose of 0.5-1.0 g/kg of body mass; and beta-carotene comprising 10-20 mg/ml of active ingredient in dose of 2 ml 1 time per day; administration intramuscularly of 1 % riboflavin mononucleotide solution 3 ml; 1 % pyridoxine hydrochloride solution 1 time per day; tetravit in dose of 3 ml 2 time during treatment course with interval for 5 days, wherein total treatment course includes 10 days.

EFFECT: method with simultaneous antioxidant, antitoxic, metabolism stimulating, and liver function normalizing action.

2 ex, 3 tbl


The invention relates to the field of veterinary medicine, in particular to a method of treatment of cattle poisoning his Chernogorneft drug contained as impurities to the Seine river, which is part of the diet.

There are several types of Chernomorka, but among them the most common is Chernomorec drug Cynoglossum officinale. As a weed biennial plant of the family Boraginaceae (spread over), Chernomorec spread on the fields and upland pasture in the forests, in gardens and vegetable gardens in all latitudes, except for the Far North. But more often Chernomorec infests sainfoin, because the seeds of these plants appearance and weight are similar and are difficult. Infestation of sainfoin Chernogorneft reaches 10-15, and long-used crops sainfoin even 70% by mass.

Poisoning pastures are rare. Often animals are poisoned when eating freshly cut grass, hay, haylage, silage, sernauto containing an admixture of vegetative mass or seed Chernomorka. Poisoning usually occur chronically and often have a mass character. Observed stunted growth of young animals, reduced milk yield, intermittent diarrhea, hypotension predzheludkov, gradual emaciation, liver disease until cirrhosis. Possible death of animals from liver nedostatocno is I.

Forced slaughter poisoned animals, lowering the quality or selection of products, as well as mortality cause enormous damage to the farms.

Methods of treating poisoned Chernogorneft animals have not been developed. Poisoned animals were drinking milk and saline laxatives, used sodium Selenite and diuretics, however, these tools proved ineffective (Mandryka I.I. Chernomorec drug - poisonous plant // veterinary medicine. - 1979. No. 9. - P.69-70).

Closest to the proposed method are recommendations for the treatment of poisoned Chernogorneft people: rest, hot tea or coffee, amidopyrine and aspirin, antihistamines and antisense funds (diphenhydramine, suprastin, pipolphen, calcium chloride), tranquilizers (seduxen, Elenium), inhalation of oxygen (Danilenko V. S., Rodionov PV Acute poisoning by plants. - 2nd ed. - Kiev: Health, 1982. - P.69-70, 88). When unidentified toxic hepatitis are recommended enemas, intravenous injection of isotonic and hypertonic solutions, especially of a 5%glucose solution (Danilevskaya, NV, AV Boxes, starchenkov SV, Shcherbakov, Handbook of veterinary therapist/ Under. red. V. Korobov, and Shcherbakov. - St. Petersburg: Izd-vo "DOE", 2001. - P. 203); chronic hepatitis - intravenous glucose and hexamethylenetetramine, giving wew is e d allohol, diet carbohydrate diet (Usha BV Veterinary Hepatology. - M.: Kolos, 1989. - 264 S.).

Significant disadvantages of these recommendations include the following:

recommendations for acute poisoning in relation to hospital treatment of the person and of little use for mass treatment of animals;

used to ensure funds are mostly symptomatic and not aimed at detoxification or excretion phytotoxins from the body;

intravenous injections are time-consuming and give complications more often than intramuscular and subcutaneous injection.

The objective of the invention is the development of a more easy to use and effective method of treatment of animals based on characteristics of toxicokinetic effectors of Chernomorka (pyrrolizidine alkaloids) and pathogenesis of poisoning.

It is known that pyrrolizidine, got alimentary infections in the body, are absorbed from the intestine into the blood flow to the liver, where they undergo N-oxidation and bioactively to pyrrole metabolites. Products metabolize circulating in the blood, damaging the endothelium of blood vessels and membranes of hepatocytes and excreted in the bile in the 12-duodenum and again sucked in behind lying areas of the intestine. Recirculation continues until the collapse or reformirovania alkaloids in other compounds the situation, or excretion with the feces.

Reactive compounds pyrrole act destructively on the membrane primarily hepato - and erythrocytes, leading to hepatitis and destruction of blood cells.

The proposed method includes the combined use of pharmacological agents, which are used:

- oral - sorbent LPCD (treatment-and-prophylactic feed additive) in a dose of 0.15 g/kg of body weight, sucrose 0.5-1.0 g/kg body mass and beta-carotene (the content of the active ingredient 10 mg/ml), 2 ml of 1 times a day for 10 days;

- injection - solution of Riboflavin mononucleotide 1%to 3 ml solution of pyridoxine hydrochloride 1% - 3 1 ml once a day for 10 days. (daily break); tetravit dose of 3 ml of 2 times during the entire course of treatment (every 5 days).

The combination of different pharmacological agents in the proposed method corresponds to the concept of reversibility of the disease in complex treatment of chronic hepatitis (Usha BV Veterinary Hepatology. - M.: Kolos, 1989 - 264 C.) and has the following objectives:

- divide the intestinal level in circulation alkaloids Chernomorka by sorption of the intestinal chyme of the silicates contained in LPCD, preventing further enters the blood and excretion from the body with fecal masses;

- improving energy security metabolic Pro is escow in the liver by detoxifying alkaloids, their derivatives and toxins endogenous origin by oral administration of sucrose. Sucrose is fermented in predzheludkov to volatile fatty acids. Of propionic acid in the liver produces glucose, which improves the detoxification function of the liver;

- activation of Riboflavin and pyridoxine redox processes, decarboxylation and transamination of amino acids, and usually reduced by poisoning pyrrolizidine alkaloids oxygenase activity in liver microsomes in order to restore protein and detoxification functions of the liver;

- protection of carotene, vitamins a and E biological membranes from free radical oxidation, which is provoked by pyrrolizidine and always there when hepatitis, including toxic origin;

- elimination of factors of liver damage by eliminating from the diet of forages containing alkaloids Chernomorka, and creating conditions for its reparative regeneration, the intensity of which in the body is higher than in any other organ of mammals.

By freeing the body of toxins and activate the metabolism increase reparative processes in the liver, restores its structure and function, normal digestion and begins recovery animals. However, when developing the ing cirrhosis or other serious organic lesions of the liver the proposed method of treatment ineffective.

The invention is characterized by examples from clinical observations and the results of morphological and biochemical studies on the blood of animals that ate food littered with Chernogorneft.

Example 1.

JSC "Krasnogvardeyskaya" clinical study 111 heifers used in the cultivation period within 3-4 months of food from sainfoin (cut grass, hay), 10-20% clogged Chernogorneft. In the study of blood serum revealed changes characteristic of liver damage: hypoalbuminemia - 15.3%, hyperimmunoglobulinemia - 31,5%, positive colloidal sediment sample by Veltman - 52,3%. The differential diagnosis is excluded leptospirosis, fasciolosis, dicroceliosis, paratuberculosis, sicarios, mycotoxicoses, poisoning substandard food.

After a 10-day comprehensive treatment of the 12 animals of the proposed method in comparison with the initial state marked decline thymol turbidity test (22.3%) and samples of Veltman (12.7%), the increase in A/G ratio.

Upon further observation of the animals found that in subsequent immediately after calving (within 4-5 days.) in cows that Nedelina age not treated, appeared exhausting diarrhea, developed progressive emaciation. The safety of these calves was 0%. Two months after calving on forced slaughter was sent 38 cows sold to the population 23 of the head. Over the next year, all the observed livestock, in addition to the 12 treated animals were culled and put on the meat.

Example 2.

In agriculture "Bolshevik" was conducted clinical examination of 300 heads 7-8 - month-old calves, which, according to history, during 3 months. fed hay from sainfoin, containing an admixture of Chernomorka. In calves was noted diarrhea, staggering walk at normal body temperature. At clinical examination of the population identified therasense hair coat, weight loss, signs of diarrhea; in a selective research - hypotension scar, offset percussion borders liver 2-3 cm, her pain jerky palpation. In the Seine, which was consumed by the calves, the detected impurity Chernomorka 1/4-1/3 of the weight.

30 calves taken blood for morphological studies. The study revealed the following:

decreased hematocrit in 16.7% of the calves;

low osmotic resistance of erythrocytes: minimum - 40-50%maximum in all animals;

high concentration of serum total bilirubin - in all animals.

Calves were divided into 3 groups: control (without treatment), pilot-1, which was used complex treatment according to the claimed alternative and experimental-2, where the skin is the very same hotel, but without beta-carotene. As criteria clinical effectiveness taken the clinical condition of the animals, hematocrit, osmotic resistance of erythrocytes and the content of bilirubin in the serum. Statistical significance of differences in the same group between indicators at the beginning and end of the experiment was accounted by T-test Wilcoxon between experimental groups and control - according to the argument Student and derived on the basis of "p" - criterion.

After the 10-day course of treatment (with odnowionym break at the weekend) the obtained results are shown in tables 1 and 2.

Compared with a baseline in the experimental group-1 hematocrit (table 1) increased by 31.3, experienced - 2 - 18.6%, while in control group it remained almost at the same level.

Compared with the control group after treatment calves claimed process hematocrit increased by 27.4% (p<0,05) versus 20.1% (p<0.05) in experimental group 2.

Significant changes also occurred with osmotic resistance. It increased in the control and experimental groups. In the control group, this increase was considering partial hemolysis 11.6, full - 13.8%. In the experimental group, which used the claimed method of treatment, partial hemolysis of erythrocytes was detected in concentration of sodium chlorine is Yes, lower than before treatment, 35.9%, full - 42.3% (T<0,01). In the comparison group, these figures were 32,0 and 39.1 per cent. Some of the increase in osmotic resistance of erythrocytes in the control group was associated with exclusion from the diet of calves feed littered with Chernogorneft. The content of total bilirubin in serum is presented in table 3.

After the applied treatment for the claimed method the content of bilirubin decreased by 52.6% and amounted to only 39.4% in the group of calves, which treatment was not applied. In Comparators version (experimental group 2) reduction of bilirubin concentration was slightly lower in relation to the initial condition (4.3%) and in comparison with the control group (8.5%). In the control group during the follow up period there was an increase of bilirubin concentration in the serum (13.2%), however this increase was not confirmed statistically (T>0,05).

In experimental groups one month after treatment, clinical signs of poisoning were not found in the control was observed less pronounced than in the initial state, hypotension scar, no diarrhea, normal appetite, 5 calves remained pain liver jerky when it palpation through the abdominal wall, the increase percussion borders of the liver by 1-2 cm

Thus, thanks to the antioxidant, antitoxic, pyrogenation usamu metabolism the effects of drugs, as well as binding a sorbent in the intestines of toxic substances and eliminate them from the body is achieved normalization of liver function and further provided that the exclusion from the diet contaminated Chernogorneft feed clinical recovery of animals and the normalization of digestion, blood condition and bilirubinuria liver function.

Table 1

The hematocrit (%) in calves before and after treatment
GroupnInitial state(before treatment)At the end of the experiment (after treatment)
M±mcompared with the initial statecompared with the control
M±m% of control%T%p
Experimental 11029.4±1.9895.438.6±1.85+31.3<0.01+27.4<0.05
Pilot 21030.7±1.3099.636.4±1.82+18.6<0.01+20.1<0.05
Control10 30.8±1.51100.030.3±1.75-1.6>0.05--

Table 3

The content of bilirubin in serum (mg %) in calves before and after treatment
GroupnInitial state(before treatment)At the end of the experiment (after treatment)
M±m% of controlM±mcompared with the initial statecompared with the control
Experimental 180.78±0.1894.00.37±0.0847.4<0.0539.4<0.05
Pilot 250.87±0.22104.80.45±0.0751.7<0.0547.9<0.05

<> Sources of information

1. Mandryka I.I. Chernomorec drug - poisonous plant // veterinary medicine. - 1979. No. 9. - P.69-70.

2. Danilenko V. S., Rodionov PV Acute poisoning by plants. - 2nd ed. - Kiev: Health, 1982. - P.69-70, 88.

3. The Danilevskaya, NV, AV Boxes, starchenkov SV, Shcherbakov, Handbook of veterinary therapist / Under. edit Aphronov and Bow. - St. Petersburg: Izd-vo "DOE", 2001. - S.

4. Usha BV Veterinary Hepatology. - M.: Kolos, 1989. - 264 C.

Additional sources of information

5. Aripov A.N. Damage to membranes of the endoplasmic reticulum of the liver when gelatinoid hepatitis and repair their phospholipid preparations: author. Diss. ...Dr. med. Sciences. - M., 1989. - 48S.

6. Busage AV Poisons of plant origin and animal feeding // Increase productivity C. agricultural animals and birds. - T.15. - Issue 3. - Pervanovo, 1980. - P.124-127.

7. Golodnitsky A.K. Sources of poisoning animals and birds of plant poisons in the Rostov region // Sat. scient. works Sowing.-The Caucasus. N.-I. wet in-TA. - Novocherkassk, 1973. - S-210.

8. Dudar A.K. Poisonous plants of meadows and pastures. - M.: Rosselchozizdat, 1980. - S.

9. Mashkovsky PPM Medicines. - Part 2. - 12th ed. - M.: Medicine, 1993. - S.

10. Podymova S.D. liver Disease. - M.: Medicine, 1993. - 544 S.

11. Prokopenko L.G., Hemp E.N., Affectionate I. Metabolic correction toxicas them and medicinal immunopathy. - Kursk: ed. Kursk. state honey. University, 1997. - S.

12. Buller D.R., C.L. Miranda, Kadzierski B., R.L. Reed Mechanism for pyrrolizidine alkaloid activation and detoxication // Biol. Reac. Intermed. 1V: Mol. And Cell. And Impact. Hum. Health. - London, 1991. - C.597 - 603.

13. Conner R.L., Declerk - Floate R.A., Leggett F.L., Bissett J.D., G.C. Kozub Impact of disease and a defoliating insect of houndstongue (Cynoglossum officinale) growth: Implications for weed biological control // Ann. Appl. Biol. - 2000. - T.136. No. 3. - C.297-305.

14. B.L. Stegelmeier, D.R. Gardner, James, L.F., R.J. Molyneux Pyrrole detection and the pathologic progression of Cynoglossum officinale poisoning in horses // J. Vet. Diagn. Invest. - 1994. - Vol.8. No. 1. - S-90.

15. Zentek J., Aboling S., J. Kamphues Accident report: animal nutrition in veterinary medicine - actual cases: houndstongue (Cynoglossum officinale) in pasture - a health hazard for horses // Dtsch Tierarztl Wochenschr. - 1999. - T. No. 11. - S-477.

The method of treatment of cattle poisoning Chernogorneft, characterized in that use oral introduction of the sorbent LPCD - medical feed additives on the basis of the aluminosilicate at a dose of 0.15 g/kg of body weight, sucrose 0.5-1.0 g/kg body mass and beta-carotene content of the active substance 10 mg/ml at a dose of 2 ml - 1 per day; intramuscular injection of a solution of Riboflavin mononucleotide 1%to 3 ml of a solution of pyridoxine hydrochloride 1% - 3 ml - 1 times a day, terravita dose of 3 ml 2 times for a course of treatment interval of 5 days, the course of treatment is 10 days.


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