Method for choosing tactics for preparing children for endoscopic testing

FIELD: medicine, endoscopy.

SUBSTANCE: one should study psychosomatic state according to questionnaire mentioned in the description followed by calculation of the points obtained. Based upon these data one should calculate the coefficient of symptoms' expressibility C = ∑/n, where ∑ - the sum of points obtained after filling in the questionnaire, n - the quantity of symptoms groups. And at C≥1.5 before endoscopic trial one should prescribe individual therapeutic course of preparations of sedative group. And at C<1.5 before endoscopic trial it is necessary to prescribe standard psychotherapeutic conversation due to paying attention upon reasons that cause dangerous fear at carrying out endoscopic trial. The innovation suggested decreases psychoemotional loadings.

EFFECT: higher efficiency.

2 ex

 

The invention relates to medicine, more specifically to methods for assessing emotional state of a patient with a specific pathology in certain social contexts.

The traditional way of indication of anxiety and depression is Scale-questionnaire Tsung for the assessment of depression and anxiety developed on the basis of the diagnostic criteria of depressive syndrome and anxiety. The scale contains 20 questions. Methods: after a brief instruction of the patient is offered the questions with 4 answers - "rarely", "rarely", "often", "most of the time or always". The score is determined in accordance with 4 grades of severity of the symptom on each item. The maximum total score is 80. Index alarm is calculated by dividing obtained during examination of the patient's total score by the maximum possible total score (80). Measurable indicators: 5 items assess affective symptoms, the remaining 15 - somatic [Zung W.W.K. How normal is anxiety? (Current concepts). Upjonh company 1980].

The disadvantage of this method is the difficulty in verbalizing subjective symptoms of depression and anxiety in pediatric patients in different age groups school age.

The traditional way of determining the index of the psychosomatic state - trevo and and anxiety of Spilberger [Lphbezac, Samorodov. The dictionary of psycho-diagnostics. S.-Petersburg, 2003, s]based on the method of psychoanalysis, selected as a prototype. According to the concept proposed Spill-Berger, on a differentiated understanding anxiety and anxiety, was developed measurement scale of anxiety and anxiety, these States are different, namely: anxiety is a condition that anxiety is a personality trait. Understanding anxiety in theory Cdecember is determined by the following provisions:

- the situation in which person a certain threat or personally important, call it an alarm condition;

- subjective anxiety is experienced as an unpleasant emotional state different intensities;

the intensity of the experience of anxiety is proportional to the degree of threat or importance of the causes of the experiences from these factors, the duration depends on the experience of the alarm condition;

- visokotsennie individuals perceive situations or circumstances that potentially contain the possibility of failure or threat, more intensely;

- the alarm is accompanied by changes in behavior or mobilizes defense mechanisms of the individual;

- repetitive stress lead to the development of typical defense mechanisms.

The test Spilberger is acetoorcein, consisting of 2 blocks of 20 affirmative questions. Questionnaire (scale) situational anxiety (ST) is filled surveyed after the presentation of the statement of the following kind: after careful reading of the following sentences, select the probe corresponding key depending on how you feel at the moment. On issues not hesitate because the correct and incorrect answers no. Choose from the 4 proposed options: 1 - no, this is not the case; 2 - perhaps so; 3 - true; 4 - not at all true.

Questionnaire (scale) personal alarm (LT) - the second set of judgments. Here the approval of the ordinary about the health of the patient. There are 4 variants of answers: 1 - almost never; 2 - sometimes; 3 - often; 4 - almost always. For data processing the test uses a "key" in accordance with the number of the question and the selected answer is assigned a score, the maximum number of points for the answer - 4. Indicators of reactive anxiety (RT) and trait anxiety (LT) are calculated by the formulas:

RT=Σ12+35

where Σ1- the sum of responses to the scale items 3, 4, 6, 7, 9, 12, 13, 14, 17, 18;

Σ2the amount of the remaining responses (paragraphs 1, 2, 5, 8, 10, 15, 20).

LT=Σ12+35

where Σ1- the sum of responses to the scale items 22, 23, 24, 25, 28, 29, 31, 32, 34, 35, 37, 38, 40;

Σ 2the amount of the remaining responses (paragraphs 21, 26, 27, 30, 33, 36, 39). When analyzing the results of self-evaluation takes into account that the total figure for each of podsol is in the range from 20 to 80 points. Thus the higher the score, the higher the level of anxiety. In the interpretation of the indicators using the following approximate evaluation anxiety: up to 30 points - low, 31-44 points - moderate, 45 and above - high.

The disadvantage of this method is the definition only symptom is anxiety, without taking into account the severity of the clinical manifestations of long-standing of the underlying disease, which influences the personal characteristics of the patient into account when drafting the physician clinical diagnostic package, and prepare children for painful methods.

The present invention is to develop tactics training children for endoscopy of the digestive tract and reduce psycho-emotional activity at this study.

The problem is solved in that determine the performance of a psychosomatic condition, for this survey the psychosomatic state of the form specified in the description, with subsequent calculation of the evaluation points and the calculation on the basis of their factor intensity of sent the MOU: To=Σ /n

where Σ - the sum of points obtained as a result of the survey,

n is the number of groups of symptoms;

and when It≥1,5 before endoscopic examination designate individual medications sedative number, when K<1,5 before endoscopic examination prescribed standard psychotherapeutic conversation with emphasis on the causes of the alarming concern during endoscopic examination.

The method is as follows. Defines the psychosomatic condition of the questionnaire, which reflects specific questions, each of which is assigned a certain number of points, taking into account the registration of clinical symptoms present in the patient, and duration of their symptoms, excluding the number of previously performed endoscopy. This indicator is critical for skilled endoscopist. This allows you to determine the strategy of carrying out endoscopy in children, which this study was carried out repeatedly.

Below is a questionnaire filled out by the child with the help of a doctor.

After completion of the questionnaire was determined by the coefficient of correlation of clinical symptoms and emotional States according to the formula:

K=Σ/n

where K - the coefficient of correlation of clinical symptoms and emotional States,

Σ - the Ummah points,

n = the number of groups of symptoms.

Maximum K=2,8. Accordingly, the higher the value of the coefficient, the more pronounced the clinical pathology of the gastrointestinal tract psychosomatic orientation. To<0.5 to minor severity, 0,5≤<1,5 - moderate severity, It≥1,5 - a vivid manifestation of psychosomatic disorders.

The main difference between the claimed process from the known is the fact that this form provides a quantitative assessment of the psychosomatic state of children in the choice of tactics training for endoscopy of the upper parts of the gastrointestinal tract.

The invention is illustrated by the following examples, which are given psychometric and psychophysiological symptoms and their dynamic changes.

Example 1. Girl K. 13 years admitted to the gastroenterology Department for evaluation of the dynamics of the disease and correction of therapeutic programs; Primary diagnosis: stomach ulcer duodenal ulcer.

According to the formula K=Σ/n calculate the coefficient of symptoms:

K=1,0/4=0,25.

Received a low ratio does not provide medical training drugs sedative number before endoscopic study, P is bodies standard psychotherapeutic conversation before endoscopy with emphasis on the causes of the alarming concern during endoscopic examination.

During endoscopic investigations using only verbal preparation of a negative reaction motor-emotional nature of the child were observed, which allowed us to conduct and complete the endoscopy, to eliminate stressful situations.

Endoscopic conclusion: Gastro. Granular hyperplastic gastritis antrum. Esophagitis. Duodenogastric reflux.

Example 2: the Boy P. 10 years, hospitalized in the Department of gastroenterology Department with guiding diagnosis of gastro, makes active complaints on frequent abdominal pain. To confirm the diagnosis and determine further tactics of completing the questionnaire.

According to the formula K=Σ/n calculate the coefficient of symptoms:

K=6,0/4=1,5.

Given the high rate K=1,5, was conducted medical training drug Phenibut in a dosage of age within 3 days prior to endoscopic examination, verbal training with elements of play therapy, and prior to endoscopic examination of the upper gastrointestinal tract was performed anesthesia laryngopharyngeal by irrigation with 1% Lidocaine solution. When performing endoscopy was supported by verbal the hydrated contact with the patient, that helped to reduce the feeling of anxiety and helplessness in these conditions, to protect from the negative effects of invasive procedures on the psycho-emotional condition of the child. After conducting EGDS with the purpose of the prescribed medication psycho-correction bulletinall in age-specific dosage for a period of 14 days.

Endoscopic conclusion: Ulcer of the duodenal bulb. Common gastritis. Duodenitis. Duodenogastric reflux. Indirect signs GIT.

The invention allows to reduce the emotional stress before and during the method - endoscopy of the upper gastrointestinal tract. Based on the analysis of questionnaires completed by a specialist in the presence of the patient, produce quantitative objective assessment of the emotional state of the child with individual psychotherapy and medication preparation before EGD.

Given the fact that the number of patients with gastroenterological diseases, about 30% are purely functional abnormalities underlying the pathogenesis lies psychosomatics [Vbnullchar, Christian, M Glad. Psychosomatic medicine. Moscow, 1999, s. (373)], using the inventive method can not only reduce the anxiety in this category of patients, but also to prevent stressful situations, subsequently negatively takes a severe toll is Sousa on the underlying disease course.

The selection method tactics training children to endoscopic study by defining indicators psychosomatic condition, characterized in that conduct a study of the psychosomatic state of the form specified in the description, with subsequent calculation of the evaluation points and the calculation on the basis of the coefficient of symptoms To=Σ/n

where Σ - the sum of points obtained as a result of the survey,

n is the number of groups of symptoms,

and when It≥1,5 before endoscopic examination designate individual medications sedative number, when K<1,5 before endoscopic examination prescribed standard psychotherapeutic conversation with emphasis on the causes of the alarming concern during endoscopic examination.



 

Same patents:

FIELD: oncology.

SUBSTANCE: method comprises administering to an animal, requiring this treatment, in a synergetic mode, therapeutically effective amount of (i) agent selected from group including cytotoxic agents and cytostatic agents and (ii) compound of formula I (given in description) or pharmaceutically acceptable salt thereof. Method provides synergic antitumor effect when using diminished doses of one or both active ingredients, prevents or slows development of multidrug resistance of tumor while ensuring destruction of both proliferative and non-proliferative tumor cells.

EFFECT: enabled use of reduced doses of drugs.

7 cl, 23 dwg, 6 tbl, 25 ex

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to new heterocyclylsulfonyl alkylcarboxylic acids and their derivatives of the general formula (1): or their pharmaceutically acceptable salts, N-oxides or hydrates possessing the inhibitory effect on kinase activity and to the focused library for search of active leader-compounds comprising at least abovementioned compound. In the general formula 91) W represents optionally substituted heterocyclic radical, among them: pyrrole-3-yl, thiophene-2-yl, isooxazole-4-yl, pyrazole-4-yl, imidazole-4-yl, pyridine-3-yl, 1H-2,4-dioxopyrimidine-5-yl, 2,3-dihydro-1H-indole-5-yl, 2,3-dihydro-1H-indole-7-yl, 1,3-dihydro-2-oxoindole-5-yl, 2,3-dioxo-1H-indole-5-yl, 2-oxo-3H-benzoxazole-6-yl, benzothiazole-6-yl, 1H-benzimidazole-5-yl, benzo[1,2,5]oxadiazole-4-yl, benzo[1,2,5]thiadiazole-4-yl, 1,2,3,4-tetrahydroquinoline-6-yl, 3,4-dihydro-2-oxo-1H-quinoline-6-yl, quinoline-8-yl, 1,4-dihydro-2,3-dioxoquinoxaline-6-yl, 3-oxo-4H-benzo[1,4]oxazine-7-yl, 3-oxo-4H-benzo[1,4]thiazine-7-yl, 2,4-dioxo-1H-quinazoline-6-yl, 2,4-dioxo-1,5-dihydrobenzo[b][1,4]diazepine-7-yl or 2,5-dioxo-3,4-dihydrobenzo[b][1,4]diazepine-7-yl; Y represents optionally substituted methylene group; R1 represents chlorine atom, optionally substituted hydroxyl group, optionally substituted amino-group, optionally substituted azaheterocyclyl; n = 1, 2 or 3; or Yn represents carbon atom of optionally substituted (C3-C7)-cycloalkyl or optionally substituted (C4-C7)-heterocyclyl. Also, invention relates to a pharmaceutical composition in form of tablets, capsules or injections placed into pharmaceutically acceptable package.

EFFECT: valuable properties of compounds.

5 cl, 3 sch, 5 tbl, 6 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new biologically active derivatives of dihydrobenzo[b][1,4]diazepine-2-one. Invention describes derivatives of dihydrobenzo[b][1,4]diazepine-2-one of the general formula (I): wherein X means a simple bond or ethynediyl group wherein if X means a simple bond then R1 means cyano-group, halogen atom, lower alkyl, (C1-C3)-cycloalkyl, (lower)-alkoxyl, fluoro-(lower)-alkyl or it means pyrrole-1-yl that may be free or substituted with 1-3 substitutes taken among the group consisting of fluorine, chlorine atom, cyano-group, -(CH2)1-4-hydroxyl group, fluoro-(lower)-alkyl, lower alkyl, -(CH2)n-(lower)-alkoxyl, -(CH2)n-C(O)OR'', -(CH2)1-4-NR'R'', hydroxy-(lower)-alkoxyl and -(CH2)n-COR'R'', or it means free phenyl or phenyl substituted with one or two substitutes taken among the group consisting of halogen atom, lower alkyl, fluoro-(lower)-alkyl, (lower)-alkoxyl, fluoro-(lower)-alkoxyl and cyano-group; if X means ethynediyl group then R1 means free phenyl or phenyl substituted with 1-3 substituted taken among the group consisting of halogen atom, lower alkyl, fluoro-(lower)-alkyl, (C3-C6)-cycloalkyl, (lower)-alkoxyl and fluoro-(lower)-alkoxyl; R2 means -NR'R'', fluoro-(lower)-alkoxyl or 3-oxopiperazin-1-yl, pyrrolidin-1-yl, or piperidin-1-yl wherein their rings are substituted optionally with R''; R' means hydrogen atom, lower alkyl, (C3-C6)-cycloalkyl, fluoro-(lower)-alkyl or 2-(lower)-alkoxy-(lower)-alkyl; R'' means hydrogen atom, lower alkyl, (C3-C6)-cycloalkyl, fluoro-(lower)-alkyl, 2-(lower)-alkoxy-(lower)-alkyl, -(CH2)2-4-di-(lower)-alkylamino-group, -(CH2)2-4-morpholinyl, -(CH2)2-4-pyrrolidinyl, -(CH2)2-4-piperidinyl or 3-hydroxy-(lower)-alkyl; Y means -CH= or =N-; R3 means halogen atom, lower alkyl, fluoro-(lower)-alkyl, (lower)-alkoxyl, cyano-group, -(CH2)n-C(O)OR'', -(CH2)1-4-NR'R'' or it means optionally substituted 5-membered aromatic heterocycle that can be substituted with halogen atom, fluoro-(lower)-alkyl, fluoro-(lower)-alkoxyl, cyano-group, -(CH2)n-NR'R'', -(CH2)n-C(O)OR'', -(CH2)n-C(O)NR'R'', -(CH2)n-SO2NR'R'', -(CH2)n-C(NH2)=NR'', hydroxyl, (lower)-alkoxyl, (lower)-alkylthio-group or lower alkyl that is optionally substituted with fluorine atom, hydroxyl, (lower)-alkoxyl, cyano-group or carbamoyloxy-group; n means 0, 1, 2, 3 or 4, and their pharmaceutically acceptable additive salts. Also, invention describes a medicinal agent as antagonist of mGlu receptors of group II based on compounds of the formula (I). Invention provides preparing new compounds eliciting valuable biological properties.

EFFECT: valuable medicinal properties of compounds.

17 cl, 496 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of benzodiazepines of the general formula (I):

wherein X means ordinary bond or ethynediyl group wherein if X mean ordinary bond then R1 means halogen atom or phenyl substituted with halogen atom optionally or (C1-C7)-alkyl group; in case when X means ethynediyl group then R1 mean phenyl substituted with halogen atom optionally; R2 means halogen atom, hydroxy-group, lower alkyl, lower alkoxy-group, hydroxymethyl, hydroxyethyl, lower alkoxy-(ethoxy)n wherein n = 1-4, cyanomethoxy-group, morpholine-4-yl, thiomorpholine-4-yl, 1-oxothiomorpholine-4-yl, 1,1-dioxothiomorpholine-4-yl, 4-oxopiperidine-1-yl, 4-(lower)-alkoxypiperidine-1-yl, 4-hydroxypiperidine-1-yl, 4-hydroxyethoxypiperidine-1-yl, 4-(lower)-alkylpiperazine-1-yl, lower alkoxycarbonyl, 2-di-(lower)-alkylaminoethylsulfanyl, N,N-bis-(lower)-alkylamino-(lower)-alkyl, (lower)-alkoxycarbonyl-(lower)-alkyl, (lower)-alkylcarboxy-(lower)-alkyl, lower alkoxycarbonylmethylsulfanyl, carboxymethylsulfanyl, 1,4-dioxa-8-azaspiro[4,5]dec-8-yl, carboxy-(lower)-alkoxy-group, cyano-(lower)-alkyl, 2-oxo[1,3]dioxolane-4-yl-(lower)-alkoxy-group, 2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrole-5-yl, (3R)-hydroxypyrrolidine-1-yl, 3,4-dihydroxypyrrolidine-1-yl, 2-oxooxazolidine-3-yl, carbamoylmethyl, carboxy-(lower)-alkyl, carbamoylmethoxy-, hydroxycarbamoyl-(lower)-alkoxy-, lower alkoxycarbamoyl-(lower)-alkoxy-, (lower)-alkylcarbamoylmethoxy-group; R3 means phenyl, thiophenyl, pyridinyl that are substituted with halogen atom, cyano-group, carbamoyl, imidazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl or isoxazolyl wherein groups of 1,2,3-triazolyl, 1,2,4-triazolyl or isoxazolyl are substituted optionally with (C1-C7)-alkyl or (C1-C7)-alkylsulfanyl, and to their pharmaceutically acceptable salts. Also, invention describes a medicinal agent that is antagonist of mGlu receptors of the group II based on compound of the formula (I). The medicinal agent can be used in treatment and prophylaxis of acute and/or chronic neurological disturbances including psychosis, schizophrenia, Alzheimer's disease, disturbances in cognitive ability and memory damage.

EFFECT: valuable medicinal properties of compounds.

7 cl, 1 tbl, 98 ex

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of benzodiazepine of the general formula (I)

and their pharmaceutically acceptable acid-additive salts wherein X means a ordinary bond or ethynediyl group; when X means ordinary bond then R1 means halogen atom, (lower)-alkyl, (lower)-alkylcarbonyl, (lower)-cycloalkyl, benzoyl, phenyl substituted optionally with halogen atom, hydroxyl, (lower)-alkyl, (lower)-alkoxy-group, halogen-(lower)-alkoxy-group or cyano-group; styryl, phenylethyl, naphthyl, diphenyl, benzofuranyl, or 5- or 6-membered heterocyclic ring representing thiophenyl, furanyl, pyridinyl, dihydropyridinyl, tetrahydropyridinyl which are optionally substituted; when X means ethynediyl group then R1 means hydrogen atom, (lower)-alkyl substituted optionally with oxo-group; (lower)-cycloalkyl substituted with hydroxyl; (lower)-cycloalkenyl substituted optionally with oxo-group; (lower)-alkenyl, optionally substituted phenyl; 5- or 6-membered heterocyclic ring representing thiophenyl, thiazolyl, pyridinyl, dihydropyridinyl, tetrahydropyridinyl or dihydropyranyl and substituted optionally; R3 means phenyl, pyridyl, thiophenyl or thiazolyl which are substituted optionally. These compounds can be used for treatment or prophylaxis of acute and/or chronic neurological diseases, such as psychosis, schizophrenia, Alzheimer's disease, disorder of cognitive ability and memory disorder. Also, invention describes a medicinal agent based on these compounds and a method for preparing compounds of the formula (I).

EFFECT: improved method for preparing, valuable medicinal properties of compounds.

10 cl, 1 tbl, 173 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves administering typical tricyclic antidepressants combined with selective reverse serotonin capture inhibitors. Anxious version of subpsychotic level depressive syndrome of endogenous genesis being treated, intravenous drop-by-drop infusion of 2.-4.0 ml of 1% amitriptiline solution per 200 ml of physiologic saline is applied in 12-14 procedures combined with selective reverse serotonin capture inhibitor given per os, Zoloft is per os administered as the inhibitor at a dose of 50-100 mg. Then, supporting Zoloft therapy is applied at a dose of 100 mg during 3 months. Atypic version of depressive syndrome of subpsychotic level and endogenous genesis is treated with intravenous drop-by-drop infusion of 1.25% Melipramine solution at a dose of 2.0-4.0 ml per 200 ml of power supply source in 12-14 infusions combined with a reverse serotonin capture inhibitor. Paxyl is taken at a peroral dose of 40-60 mg as the inhibitor. Then, supporting Paxyl therapy is applied at a dose of 40-60 mg during 3 months.

EFFECT: enhanced effectiveness of treatment; reduced risk of complications; accelerated depressive syndrome relief.

The invention relates to imidazole derivative of the formula (I)

or its pharmaceutically acceptable salt

The invention relates to medicine, anesthesiology and critical care medicine, and can be used as anesthesia during incoherencies operations on the organs of abdominal cavity

FIELD: experimental medicine.

SUBSTANCE: an animal should be presented with spatially distributed target stimuli that require implementation of desired motor reaction followed by reinforcement. Reinforcement at reacting the presentation of one of the target stimuli should be increased by 4-6 times to be presented by discrete portions coming at intervals of not less than 3 sec. Along with target stimuli it is necessary to introduce constantly acting visual stimuli that enable to detect the location of the greatest reinforcement in the row of spatially distributed target stimuli. Testing for the capacity for changing attention from target stimuli to constantly acting visual reference points should be fulfilled with separate samples due to their simultaneous inclusion, moreover, application of samples for attention should be started after 4-5 times of presenting each of target stimuli altered in random order. Indicator for the presence of attention deficiency is considered to be animal's incapacity to infallible fulfillment of 4 testing sample running at initial location of the greatest reinforcement and alteration of its spatial localization.

EFFECT: higher efficiency of diagnostics.

3 dwg

FIELD: medical equipment.

SUBSTANCE: device has operator's control board, generators, power source, brightness changing unit, adders; lower frequency filter, cursor index lighting nit, light filters units, cursor index forming units, range finding units and so on as well as channels for bringing units into communication. Device also has program setting unit, scaling unit, switch which has first input connected with output of periodic signal frequency detector through scaling unit. Device has test showing manual control drive, integrator which has input connected with output of time interval detector. Device also has unit for finding average time of test right performance, additional operator's control board connected in series with random signal generator, program output unit which has second input connected with output of program setting unit, test showing unit which has second input connected with output of switch. Video control device has second and third outputs connected with second outputs of operator's additional control board and random signal generator correspondingly. Output of video control unit is connected with second input of unit for measuring average time for correct performance of test. Device provides 10-15% increase of operation of human operators.

EFFECT: widened functional capabilities; higher precision of estimation of psycho-physiological tiredness of operators; ability of correction of operator's condition.

1 dwg

FIELD: medical equipment.

SUBSTANCE: device can be used for testing parameter of human viewing system. Device has control board, point light source, counter, indication unit, pulse generator, millisecond pulse generator, first univibrator, second univibrator with controlled pulse duration, third univibrator, OR gate, AND gate, fourth univibrator and flip-flop.

EFFECT: widened functional capabilities.

4 dwg

FIELD: medicine; occupational hygiene.

SUBSTANCE: variable frequency signals are presented to tested person being at rest or at tired condition and factors of his/her reaction to the signals are measured. Signals shown to tested person are formed in shape of tests to be solved. Conditions and result of the tests are shown on screen of videocontroller. Number of tests for persons being at relaxed or tired condition are preset to be equal. The test are shown in random sequence at frequency being changed proportionally to frequency of their solving. Total time from beginning till end of solution needed for preset test is measured as well as total time of delay in outputting shown conditions of tests and results of their solution to screen of videocontroller when taking corrections into account. Number of tests solved right is determined and total time for solving the tests deducting the time for making corrections is measured. Workability is estimated on the base of change in average time for making right solution of the test. Method provides independence of results on equipment used for the tests.

EFFECT: improved truth of estimation.

FIELD: medicine.

SUBSTANCE: method involves determining the number of testees of high professional success whose results exceed standard level on informative indices used in various methods. Integral distribution law is built on the testee set and error threshold is determined. The value is used for dividing the testees having passed the tests according to the same methods into employment-fit and unfit ones. Boundary dividing the set into employment-fit and unfit persons is determined on total error number being less than 0.8-0.9.

EFFECT: high reliability in determining employment fitness in single group.

4 cl, 1 dwg

FIELD: medicine; psychology.

SUBSTANCE: members of family are interviewed and identified members of family are found. Genogram to represent structure of family system is composed. Members of family are subject to psychotherapeutic treatment. Sort and degree of crisis condition of family are determined additionally. On the basis of interrogation and while taking objective data on functional condition of family members into account, medicinal activities are performed and group psychotherapeutic treatment is carried out during 40 hours for 10 days in total. Group psychotherapeutic treatment is carried out with members of several families being at different degrees of crisis. Number of participants in the group equals to 12 to 14 people. Participants are randomly combined in pairs on the condition that those pairs are composed of different family's members. During first day of activities the stress of non-worked negative emotions is removed by means of corporal-oriented Reich massage during 120 minutes. Since second to the ninth day of treatment, participants work with any member of crisis family in turn. Any member of a family expresses his/her opinion concerning actual crisis situation in his/her family. During group discussion of future models of structure of connections between members of a family, the optimal decision is looked for making changes in structure of system connections in the family. On the tenth day, the final step of group therapeutic treatment, the method of holotropic breathing technique is used for strengthening positive emotional experience. One-hour breathing session is performed followed by discussion on emotional experience. After it emotional condition of members of crisis family is subject analysis. Low degree of anxiety testifies successful completion of treatment.

EFFECT: improved efficiency.

1 ex, 3 tbl, 2 dwg

FIELD: medical equipment.

SUBSTANCE: device can be used for evaluation of psychological tests and diagnostics, in particular for evaluating availability of conflict or conflict-free operation of operators. Device has at least two boards for operators to be tested. Any board has variable resistor with handle, voltage/current source, analog-to-digital converter, interface unit, unit for controlling indicator. Tester's unit has interface units being equal to number of tester's board, signal commutator, computational unit, indication signal former, data storage, monitor, and unit for setting and controlling parameters.

EFFECT: widened functional abilities.

3 dwg

FIELD: medicine.

SUBSTANCE: method involves recording individual minute magnitude in s. Total score falling in Beck depression scale by 30% and more, mean test score value time consciousness being increased by 14% and higher, individual minute magnitude being increased by 40% and more at the fourteenth and twenty eighth treatment day when compared to the data before treatment, the treatment is thought to be effective. The individual minute magnitude being increased by 19% and less at the twenty eighth treatment day when compared to the value before treatment, following recurrent clinical depressive disorder course is to be predicted.

EFFECT: high accuracy of diagnosis.

3 dwg

FIELD: medicine.

SUBSTANCE: method involves giving temperament feature score evaluation using Thomas questionnaire. Quantitative temperament feature magnitudes like general activity, sleep activity, threshold, intensity, mood are summed up and declared as behavior property of activity. Activity as behavior property is evaluated according to following scale: less than 10 scores is assigned to a person of low activity, equal to or greater than 10 but less than 15 scores is given to a person of moderate activity, more than 15 scores receives a person of high activity degree. Quantitative magnitude of temperament features like distractibility, insistence, approximation are used for characterizing behavior property like purposefulness. Purposefulness is estimated according to following scale: less than 6 scores are given to indifferent person, equal to or greater than 6 and less than 9 are given to interested person, more than 9 scores are given to purposeful personality. Quantitative temperament feature values like sleeping rhythm, eating rhythm, habits rhythm, flexibility are summed up and behavior property like plasticity is determined. Plasticity is estimated from the following scale: less than 8 scores is given to rigid person, equal to or greater than 8 and less than 12 are given to a person of moderate firmness, more than 12 scores are given to labile person. Quantitative temperament feature values of three behavior properties are interpreted in terms of one of available 7 AIP-types of temperament: moderate activity interested of moderate firmness, moderate activity purposeful of moderate firmness, high activity interested of moderate firmness, moderate activity interested rigid, moderate activity indifferent of moderate firmness, of low activity, of seldom frequency.

EFFECT: high accuracy of method.

2 dwg, 7 tbl

FIELD: medicine, balneotherapy.

SUBSTANCE: One should perform medicinal therapy with thyroxine at the dosage of 25-75 mcg/d in the morning, about 30-40 min before breakfast, take circulatory shower at 35-36 C with fresh water, perform manual surface massage of jugular area. Additionally, one should perform rational psychotherapy that includes interpretation of curative effect of radon-containing baths, suggestion of patient's adequate attitude towards his/her disease, development of positive prognosis of the disease and correction of emotional sphere. Radon-containing baths at radioactivity concentration being 0.14-0.3 kBq/l at 36-37 C should be conducted by the following scheme: the 1st d - 5 min, the 2nd d - 8 min, the 3d d - 10 min, the 4th d - the rest, the 5th d - 12 min, the 6th d - 15 min, the 7th d - the rest, the 8th d - 15 min, the 9th d - 15 min and then - the day of rest and two next days - baths per 15 min, 15 baths totally; in case of diffuse intoxic goiter by the following scheme: the 1st d - 5 min, the 2nd d - 8 min, the 3d d - 10 min, the 4th d - the rest, the 5th d - 12 min, the 6th d - 15 min, the 7th d - the rest, the 8th d - 15 min, the 9th d - 15 min, the 10th d - the rest, the 11th d - 15 min, the 12th d - 15 min, the 13th d - the rest, the 14th d - 15 min, 10 procedures totally from 1 to 5 p.m. Moreover, daily promenades both in the evening and in the morning per 60-120 min, each are, also, very useful. Moreover, evening promenade should be combined with suggestive psychotherapy. The method enables to achieve euthyroidism and decrease goiter's size, prolong remission terms, increase inspecific body resistance and normalize oxygenation and trophic processes in peripheral tissues, vascular tonicity and homeostasis.

EFFECT: higher efficiency of complex therapy.

2 cl, 2 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: method involves forming signals as tests requiring solution. The tests are shown with frequency changed proportionally to the frequency they are solved. The number of tests is set to be the same in the cases of recovered and tired state. General amount of time spent for finding solution for given number of tests and the number of tests having right solutions are determined in each state. Mental fatigue degree is evaluated from relative change of mean time needed for finding the right test solution using a relationship like (Tm.r- Tm.t)100%/Tm.t, where Tm.t = Tsum.t/Kr.t, Tm.r = Tsum.r/Kr.r, Tm.t is the time spent for finding the right answer in tired state, Tm.r is the time spent for finding the right answer in recovery state, Tsum.t is the total time spent to solve given number of tests in tired state, Tsum.r is the total time spent to solve given number of tests in recovered state, Kr.t is the number of right answers to the tests in tired state, Kr.r is the number of right answers to the tests in recovered state.

EFFECT: reliable estimation of fatigue degree.

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