Method for treating otomycosis

FIELD: medicine, otorhinolaryngology.

SUBSTANCE: the present innovation deals with treating mycotic diseases of ears, particularly external otomycosis, otitis mycotica media and otomycosis of post-operational cavity. For this purpose, it is necessary to treat one's ear, then one should apply fir spring coniferous needles or branches and common salt at the ratio of (g) 8:1 - 12:1/1000 ml 70%-ethanol. The present solution should be supplemented with liposomes of egg lecithin at the quantity of 100 mg/ml at the size of 200-250 nm. The present method enables to decrease side effects and toxicity due to applying a medicinal preparation that contains plant components.

EFFECT: higher efficiency of therapy.

1 cl

 

The invention relates to medicine, namely to otolaryngology, and can be used to treat fungal infections of the ears, in particular outside otomycosis, secondary fungal otitis and atomikos postoperative cavity.

The study of mycotic lesions of the ear began in the mid-nineteenth century, however, to date no clear idea about the frequency of this type of pathology in inflammatory processes of the ear. Based on the analysis of statistical data shows that atomicity are ubiquitous and the frequency of the disease sufficiently defined climatic conditions. On the basis of data on species or generic characteristics of fungi pathogens atomikos follows that pathogens of fungal diseases of the ears may be different fungi, but most often they are mold genera Aspergillus, Penicillium, Mucor and yeast-like Candida. At present, there are over 150 species of pathogenic fungi, which are described as pathogens of otomycosis.

Clinical manifestations of otomycosis are the result of vegetative fungi in the ear and are largely responsible for the localization of the ear process.

The majority of patients noted a subtle beginning and a slow, gradual progression of the disease with periodic exacerbation of the process. The prognosis of the disease in a timely mustache is yavlenie diagnosis and conduct of appropriate antifungal therapy is favorable, however, atomikos can cause serious complications, leading to hearing loss and death.

Known comprehensive method for the treatment of otomycosis, including the use of pulsed CO2-laser radiation on the background of local antimycotic drugs, which use weak solutions mercury dichloride, solutions of potassium permanganate and silver nitrate, an aqueous solution of boric acid and others (the book "Actual problems of clinical otorhinolaryngology. Proceedings of the international conference." - Irkutsk, September 24-25, 1992, a - M., 1992. - S-275).

The disadvantages of this method include the restriction of its scope only fungal skin lesions of the external auditory canal, the low efficiency of the local antimycotic drugs and the relatively high cost of treatment.

There is a method of treatment of patients with mycotic lesion as the outer and middle ear, and postoperative ear cavities alcoholic solution of chelerythrine (Vaseliska. Mycoses in otorhinolaryngology. -M.: Medicine, 1989. -P.106, 108-110). The essence of this method of treatment is that first produce toilet ear, i.e. thorough cleaning of the lesion from mycotic masses, for example, using a cotton toround moistened with peroxide, and then in the ear centuries is completed with cotton pads soaked sulfate chelerythrine in a 0.2%alcohol solution, or impose on 8 drops 4 times a day. Sanguinarine is a broad spectrum antibacterial drug action. He is active In vitro against both gram-positive and gram-negative bacteria and some protozoa. Revealed its activity against pathogenic fungi. Evaluation of results of treatment by a known method shows that the effectiveness of the treatment of various forms of otomycosis and the occurrence of relapse are significantly different and in some cases are inadequate. In addition, the antifungal drug is expensive and available in limited amount.

A method of treatment of otomycosis, including toilet ear and the impact on the affected areas with a solution of drugs alcohol-based. New in the proposed method is that the affected areas are affected by therapeutic agents on the basis of 70%ethyl alcohol, and as a therapeutic drug use fir spring needles and salt in a ratio (in grams) from 8:1 to 12:1 in 1,000 ml of ethanol. The difference is that in the solution are additionally injected liposomes of egg lecithin in the amount of 100 mg/ml of the size of 200-250 nm.

The positive effect resulting from the application proposed the military way of treatment is to reduce by 1.5-2.0 times the average duration of the treatment period until the disappearance of clinical manifestations. For the application of the method does not require expensive equipment and medicines, i.e. this method of treatment can be used in the medical organization at any level where there is an otolaryngologist.

As the basis of the medicinal solution, it is proposed to use 70%ethanol. In the known methods of treatment use of alcohol is not always effective and justified, as fungistatic effect on fungi has 70-96%alcohol, and the concentrations may cause damage to the epithelium of the skin of the external auditory passages. Alcohol in a concentration of up to 70% does not damage the skin, but it is, especially at concentrations up to 50%, does not possess fungicidal properties.

Below is a description of the proposed method for the treatment of fungal infections.

A necessary condition for effective therapy is a thorough cleaning of the mycotic lesion mass. Cleaning is performed using a cotton toround soaked in 3%hydrogen peroxide. If the patient has granulation on the eardrum, prior to the beginning of medical treatment they should be removed surgically. For the treatment of fungal otitis using a solution containing 1000 ml of 70%ethanol, and fir spring needles and salt in a ratio (in grams) of 10:1. To improve bioavailability, rollover effects, increased the I stability and accelerate epidermization lesion in the solution was added to liposomes from egg lecithin size of 200-250 nm in the amount of 100 mg per 1 ml of alcohol, which adsorb on the drugs themselves. This solution moisten cotton pads and put them in my ear, and when the outer atomikos and mycotic lesions of postoperative cavities pads left in a patient ear for 10-15 minutes and repeat this operation 4-5 times a day, and in the treatment of secondary mycotic otitis solution can be injected in the form of droplets, usually 8 drops 4 times a day. The treatment for two weeks. Itching in the ear disappears, usually after 5-6 hours, and begins epithelialization of the wound. General treatment, depending on the tolerability of the preparation, conduct antibiotics - nystatin, leporinum, amfoglyukamina, nizoral according to normal procedures. Given that in the pathogenesis of mycotic diseases of the ear plays an important role in infectious-allergic factor, is recommended as a specific hyposensitization vaccines, and nonspecific desensitized therapy diazolinum, suprastin, tavegil and etc. To prevent recurrence of otomycosis month spend 2-3 course of 10 days, local antifungal therapy.

The ratio in the solution fir spring needles and salt can be changed in the range from 8:1 to 12:1, because reducing a specified ratio decreases the effectiveness of treatment, and with further increase of the ratio of its efficiency is not increased.

1. A method of treating otomycosis, including toilet ear and the impact on the affected areas of an alcoholic solution of drug, characterized in that as drug use fir spring needles and salt in a ratio (in grams) from 8:1 to 12:1 to 1000 ml of 70%ethyl alcohol.

2. A method of treating otomycosis according to claim 1, characterized in that the solution further injected liposomes of egg lecithin in the amount of 100 mg/ml of the size of 200-250 nm.



 

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