Method for treating otomycosis
FIELD: medicine, otorhinolaryngology.
SUBSTANCE: the present innovation deals with treating mycotic diseases of ears, particularly external otomycosis, otitis mycotica media and otomycosis of post-operational cavity. For this purpose, it is necessary to treat one's ear, then one should apply fir spring coniferous needles or branches and common salt at the ratio of (g) 8:1 - 12:1/1000 ml 70%-ethanol. The present solution should be supplemented with liposomes of egg lecithin at the quantity of 100 mg/ml at the size of 200-250 nm. The present method enables to decrease side effects and toxicity due to applying a medicinal preparation that contains plant components.
EFFECT: higher efficiency of therapy.
The invention relates to medicine, namely to otolaryngology, and can be used to treat fungal infections of the ears, in particular outside otomycosis, secondary fungal otitis and atomikos postoperative cavity.
The study of mycotic lesions of the ear began in the mid-nineteenth century, however, to date no clear idea about the frequency of this type of pathology in inflammatory processes of the ear. Based on the analysis of statistical data shows that atomicity are ubiquitous and the frequency of the disease sufficiently defined climatic conditions. On the basis of data on species or generic characteristics of fungi pathogens atomikos follows that pathogens of fungal diseases of the ears may be different fungi, but most often they are mold genera Aspergillus, Penicillium, Mucor and yeast-like Candida. At present, there are over 150 species of pathogenic fungi, which are described as pathogens of otomycosis.
Clinical manifestations of otomycosis are the result of vegetative fungi in the ear and are largely responsible for the localization of the ear process.
The majority of patients noted a subtle beginning and a slow, gradual progression of the disease with periodic exacerbation of the process. The prognosis of the disease in a timely mustache is yavlenie diagnosis and conduct of appropriate antifungal therapy is favorable, however, atomikos can cause serious complications, leading to hearing loss and death.
Known comprehensive method for the treatment of otomycosis, including the use of pulsed CO2-laser radiation on the background of local antimycotic drugs, which use weak solutions mercury dichloride, solutions of potassium permanganate and silver nitrate, an aqueous solution of boric acid and others (the book "Actual problems of clinical otorhinolaryngology. Proceedings of the international conference." - Irkutsk, September 24-25, 1992, a - M., 1992. - S-275).
The disadvantages of this method include the restriction of its scope only fungal skin lesions of the external auditory canal, the low efficiency of the local antimycotic drugs and the relatively high cost of treatment.
There is a method of treatment of patients with mycotic lesion as the outer and middle ear, and postoperative ear cavities alcoholic solution of chelerythrine (Vaseliska. Mycoses in otorhinolaryngology. -M.: Medicine, 1989. -P.106, 108-110). The essence of this method of treatment is that first produce toilet ear, i.e. thorough cleaning of the lesion from mycotic masses, for example, using a cotton toround moistened with peroxide, and then in the ear centuries is completed with cotton pads soaked sulfate chelerythrine in a 0.2%alcohol solution, or impose on 8 drops 4 times a day. Sanguinarine is a broad spectrum antibacterial drug action. He is active In vitro against both gram-positive and gram-negative bacteria and some protozoa. Revealed its activity against pathogenic fungi. Evaluation of results of treatment by a known method shows that the effectiveness of the treatment of various forms of otomycosis and the occurrence of relapse are significantly different and in some cases are inadequate. In addition, the antifungal drug is expensive and available in limited amount.
A method of treatment of otomycosis, including toilet ear and the impact on the affected areas with a solution of drugs alcohol-based. New in the proposed method is that the affected areas are affected by therapeutic agents on the basis of 70%ethyl alcohol, and as a therapeutic drug use fir spring needles and salt in a ratio (in grams) from 8:1 to 12:1 in 1,000 ml of ethanol. The difference is that in the solution are additionally injected liposomes of egg lecithin in the amount of 100 mg/ml of the size of 200-250 nm.
The positive effect resulting from the application proposed the military way of treatment is to reduce by 1.5-2.0 times the average duration of the treatment period until the disappearance of clinical manifestations. For the application of the method does not require expensive equipment and medicines, i.e. this method of treatment can be used in the medical organization at any level where there is an otolaryngologist.
As the basis of the medicinal solution, it is proposed to use 70%ethanol. In the known methods of treatment use of alcohol is not always effective and justified, as fungistatic effect on fungi has 70-96%alcohol, and the concentrations may cause damage to the epithelium of the skin of the external auditory passages. Alcohol in a concentration of up to 70% does not damage the skin, but it is, especially at concentrations up to 50%, does not possess fungicidal properties.
Below is a description of the proposed method for the treatment of fungal infections.
A necessary condition for effective therapy is a thorough cleaning of the mycotic lesion mass. Cleaning is performed using a cotton toround soaked in 3%hydrogen peroxide. If the patient has granulation on the eardrum, prior to the beginning of medical treatment they should be removed surgically. For the treatment of fungal otitis using a solution containing 1000 ml of 70%ethanol, and fir spring needles and salt in a ratio (in grams) of 10:1. To improve bioavailability, rollover effects, increased the I stability and accelerate epidermization lesion in the solution was added to liposomes from egg lecithin size of 200-250 nm in the amount of 100 mg per 1 ml of alcohol, which adsorb on the drugs themselves. This solution moisten cotton pads and put them in my ear, and when the outer atomikos and mycotic lesions of postoperative cavities pads left in a patient ear for 10-15 minutes and repeat this operation 4-5 times a day, and in the treatment of secondary mycotic otitis solution can be injected in the form of droplets, usually 8 drops 4 times a day. The treatment for two weeks. Itching in the ear disappears, usually after 5-6 hours, and begins epithelialization of the wound. General treatment, depending on the tolerability of the preparation, conduct antibiotics - nystatin, leporinum, amfoglyukamina, nizoral according to normal procedures. Given that in the pathogenesis of mycotic diseases of the ear plays an important role in infectious-allergic factor, is recommended as a specific hyposensitization vaccines, and nonspecific desensitized therapy diazolinum, suprastin, tavegil and etc. To prevent recurrence of otomycosis month spend 2-3 course of 10 days, local antifungal therapy.
The ratio in the solution fir spring needles and salt can be changed in the range from 8:1 to 12:1, because reducing a specified ratio decreases the effectiveness of treatment, and with further increase of the ratio of its efficiency is not increased.
1. A method of treating otomycosis, including toilet ear and the impact on the affected areas of an alcoholic solution of drug, characterized in that as drug use fir spring needles and salt in a ratio (in grams) from 8:1 to 12:1 to 1000 ml of 70%ethyl alcohol.
2. A method of treating otomycosis according to claim 1, characterized in that the solution further injected liposomes of egg lecithin in the amount of 100 mg/ml of the size of 200-250 nm.
FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to water-soluble azole compounds that can be used in biology and medicine. Invention describes a water-soluble azole compound of the formula (I):
or its pharmaceutically acceptable salt wherein each R and R1 means independently hydrogen atom or (C1-C6)-alkyl; A means group of the formula:
wherein R3 represents phenyl group with one or more halide atoms as substitutes; R4 represents hydrogen atom or -CH3; R5 represents hydrogen atom or in common with R4 it can represent =CH2; R6 represents 5- or 6-membered nitrogen-containing cycle that can comprise if necessary as substituted one or more groups taken among halogen atom, =O group, phenyl substituted with one or more groups taken among -CN, -(C6H4)-OCH2-CF2-CHF2 and -CH=CH-(C6H4)-OCH2-CF2-CHF2 or phenyl substituted with one or more groups taken among halogen atom and methylpyrazolyl group. Also, invention describes a method for preparing a water-soluble azole compound. Invention provides preparing new compounds that can be useful in medicine.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a ketoconazole-base antifungal pharmaceutical composition. The composition is prepared as a solid medicinal formulation. The composition comprises the following components, wt.-%: ketoconazole, 50.5-75.0; lactose, 1.0-12.0; starch, 5.0-25.0; polyvinylpyrrolidone, 2.0-12.0; stearic acid or calcium, magnesium or zinc stearate or mixture of indicated compounds, 0.2-1.2; aerosil and/or talc, 0.5-10.0. The novel antifungal composition comprises ketoconazole in the amount 50 wt.-%, not less, and it satisfies Pharmacopoeia requirements, stable in storage for 2 years, not less, and shows high therapeutic activity.
EFFECT: improved and valuable medicinal and pharmaceutical properties of composition.
3 cl, 2 tbl, 6 ex
SUBSTANCE: treatment consists in administration of alpha-1-adrenoblocker. Therapy is continued within 4-8 weeks in effective dose. Method leads to aggravation of symptoms of disease during the treatment followed by stopping manifestations of disease after cessation of giving preparation due to elimination of disbalance in functioning of current-coordinated detrusor-cervix-urethra system.
EFFECT: expanded possibilities in treatment of stress-caused urological diseases.
7 cl, 2 ex
SUBSTANCE: the present innovation deals with antimycotic composition that includes either antibody or antigen-binding fragment being specific to the epitope of mycotic protein of thermal shock, and antimycotic agent for treating mycotic infections, where fungus is resistant to the agent mentioned per se. Moreover, a kit for treating mycotic diseases is also suggested.
EFFECT: increased number of antimycotic means.
11 cl, 23 tbl
FIELD: medicine, dermatology.
SUBSTANCE: invention proposes an anti-infectious preparation comprising the combination of active substances with topical and systemic antifungal agents and a water-insoluble film-forming agent. The systemic antifungal agent is taken among the group including intraconazole, terbinafine and fluconazole or their salts. The topical antifungal agent is taken among the group including ciclopirox, 6-(2,4,4-trimethylpentyl)-1-hydroxy-4-methyl-2(1H)-pyridone, amorolfine and butenafine or their salts. The preparation is used as lacquer for nails in therapy of onychomycosis. The lacquer preparation provides high concentration of systemic antifungal agents in nails after its topical applying. The significant advantage of the preparation involves short time in treatment of anychomycosis.
EFFECT: enhanced effectiveness and valuable medicinal properties of preparation.
6 cl, 6 ex
FIELD: medicine, veterinary science.
SUBSTANCE: a new group of compounds, such as: 1) 1.3-benzodixole-5-β-nitroethylene
, 2) 1.3-benzodioxole-5-β-nitropropylene
, 4) 2-methylbenzimidazole-5-β-nitroethylene
, 5) benzoxazole-5-β-nitroethylene
, 6) 2-methylbenzoxazole-5-β-nitropropylene
has been suggested to protect against the agents of bacterial, protozoan and fungoid nature. Compounds are being the derivatives of heteronitroalkenes (dioxoles, oxazoles, imidazoles) with below-mentioned structural formulas being efficient to gram-positive bacteria and gram-negative aerobes, fungi of Candida, Trichophyton and other types, trichomonads. They could be applied at treating wound infections, fungoid lesions, septic states, pneumonia, trachoma, ornithosis, salmonellosis.
EFFECT: higher efficiency of protection.
5 cl, 5 tbl
FIELD: medicine, dermatology, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to an antifungal gel pharmaceutical composition based on ketoconazole and clotrimazole that are derivatives of imidazole. The composition comprises ketoconazole or clotrimazole as an active component, polyethylene glycol-400 (PEG-400) as a solvent, carboxyvinyl polymer as a gel-forming agent, polyethylene glycol as a gel stabilizing agent, organic amine or inorganic bas as a regulator of pH and water taken in the definite ratio of components. The composition is prepared by dissolving active component in PEG-400, dispersing carboxyvinyl polymer in water, successive addition to dispersion propylene glycol as a stabilizing agent and regulator of pH and combination of prepared solution and gel followed by stirring the mixture up to preparing the gel composition with pH 5-7. Invention provides preparing antifungal composition with reduced adverse effect.
EFFECT: improved preparing method, valuable medicinal properties of composition.
2 cl, 1 tbl, 11 ex
FIELD: medicine, veterinary science, mycology.
SUBSTANCE: the suggested preparation for external application includes the mixture of Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes homogenates at the ratio of 1:1:2 in solvent, for example, in physiological solution, and formalin. Concentration of mycotic elements corresponds to 50.0-500.0 mln./ml ready-to-use product. This preparation should be applied in the method to treat dermatomycosis due to rubbing it into affected skin sites till hyperemia at 0.2-2.0 ml preparation/1-4 sq.cm skin surface once daily for 4-6 d. Both the preparation and the method suggested provide healing during the terms mentioned being convenient, reliable and efficient.
EFFECT: higher efficiency of therapy.
4 cl, 5 ex
FIELD: chemico-pharmaceutical industry.
SUBSTANCE: the present innovation deals with new stabilized pharmaceutical composition in its lyophilized form including the compound of formula I
as an active ingredient and lactose disaccharide as a stabilizing agent. The present pharmaceutical compositions are of high stability at storage. As for active ingredient it is not destroyed in the course of time.
EFFECT: higher efficiency.
10 cl, 15 ex, 6 tbl
SUBSTANCE: preparation comprises echinocandine substance of formula I or its pharmaceutically permissible salt, pharmaceutically permissible micelle-forming surface-active agent and non-toxic aqueous solvent and stabilizing agent.
EFFECT: improved stability and bioaccessibility properties.
48 cl, 4 tbl
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new derivatives of triazaspiro[5,5]undecane of the formula (I):
wherein values of radicals R1-R5 are given in the invention claim, ort o their quaternary ammonium salts, N-oxides or nontoxic salts. Proposed compounds possess inhibitory and regulating activity with respect to chemokine/chemokine receptors and can be useful in prophylaxis and treatment of different inflammatory diseases, such as asthma, atopic dermatitis, nettle rash, allergic diseases, nephritis, hepatitis, arthritis or proliferative arthritis and other similar diseases. Also, invention relates to pharmaceutical compositions based on compounds of the formula (I).
EFFECT: improved control method, valuable medicinal properties of compounds.
9 cl, 5 sch, 36 tbl, 70 ex
FIELD: medicine, otolaryngology.
SUBSTANCE: the present innovation deals with introducing neomycin sulfate antibiotic in granules prepared by the following technique. Tablet of neomycin sulfate 1.0g should be put into a vial with 100 ml distilled water till tablet's decomposition. Then vial's content should be shaken and kept till suspension sedimentation. In a day one should take 1 ml of supernatant liquid to be put into another vial and diluted with distilled water at 1:100 ratio. This procedure should be repeated 4 times more, moreover, during the last procedure one should apply alcohol for dilution. Then one should transfer the drop of alcoholic solution into a vial with granules out of milk sugar to then shaken and kept open for 1 d till granules" drying up. The suggested preparation should be applied per 1 granule under the tongue, moreover, multiplicity and duration of the above-suggested intake should be matched individually by patient's sensitivity and obtaining the clinic effect. The method enables to improve the value of tonic threshold audiometry by about 30-50 dB, decrease perception threshold of vocal range frequencies and widen the range towards high frequencies.
EFFECT: higher efficiency of therapy.
FIELD: medicine, infectious diseases, psychotherapy.
SUBSTANCE: method involves antiviral therapy, immune correction with thymus hormones and interferon inductors. Since the first day the relapse symptom method involves prescription of antiox+ (1 capsule per a day) and detox+ (1 capsule, 2 times per a day) for 30 days, profluzak (20 mg, 3 times per a day for 5 days) and then in the dose 20 mg, 1 time per a day for 20 days. Derinate is prescribed topically as installation into urethra in the dose 3-5 ml or with tampon into vagina and with simultaneous prescription of microenemas in the dose 10-40 ml for 10 days. Since 10-14 day in exacerbation period in the proliferative stage of an antiherpetic immune response derinate is prescribed by intramuscular injections in the dose 5 ml, 1 time in a day, 10 injections in total number. Then since 6-th day of exacerbation and intake of profluzak psychotherapy seances are carried out. The first seance of rational psychotherapy involves explanation to a patient in available form mechanism of the disease, the necessity of prolonged treatment and motivation for treatment is enhanced by suggestion. The second psychotherapy seance involves neurolinguistic programming wherein a patient colorful and detailed description of desirable function when he imagines achievement of the desire result, and positive emotional and vegetative symptoms are notes and the conditional-reflect association is formed by tactile contact. Under psychotherapist control a patient imagines "part of person" responsible for achievement of the desire result the patient attention is accented for the desire result and arisen physiological responses are fixed by using tactile contact. Also, new behavior methods are proposed to take for a patient that are directed for achievement of the desire result - avoiding sexual contacts during exacerbation of genital herpes in one of partner and during every month hormonal cycles, avoiding stress situations, and in case of each stress situation significant for patient profluzak has to be intake in a single dose 40 mg, using a condom in sexual contact in the exacerbation period. Patient analyzes the proposed new behavior methods that help avoiding relapses, provide good state of health, promotes to recovery process of genitals recovery and selects at least three the most rationally available for him behavior methods. In the case of the positive response that is controlled by physiological symptoms the result is fixed by tactile contact. The third seance involves the suggestive psychotherapy directed for fixing the attained result. The suggestive therapy seance is carried out once per a week for 6 months. Method provides declining the treatment time, to reduce relapse frequency of genital herpes and to recover the emotional state of patient.
EFFECT: improved treatment method.
2 cl, 3 tbl, 1 ex
FIELD: medicine, dermatology, pharmacy.
SUBSTANCE: invention proposes a topical solution for treatment of solar lentiginosis and hyperpigmentated injures showing prolonged stability in storage and comprising the following components: (a) from about 0.5 to about 5 wt.-%/vol. of 4-hydroxyanisole; (b) from about 0.002 to about 0.05 wt.-%/vol. of tretinoin; (c) from about 2 to about 10 vol./vol.% of liquid low-molecular polyethylene glycol; (d) from about 0.001 to about 1.5 wt.-%/vol. of antioxidant or mixture of antioxidants. Antioxidants or mixtures of antioxidants are taken so to provide at least two functions of oxygen absorption, free-radical chain rupture or reduction: (e) from about 0.001 to about 0.1 wt.-%/vol. of chelating agent; (f) from about 50 to about 88 vol./vol.% of lower alcanol; and (g) water, up to 100%. Proposed solution has pH value from about 2.5 to about 5 and water content at least 12 vol./vol.%. Invention provides enhancing stability of the solution.
EFFECT: improved and valuable properties of composition.
13 cl, 1 ex