Method for treatment of patients with relapsing genital herpes in formation of anxious-depressive disorders

FIELD: medicine, infectious diseases, psychotherapy.

SUBSTANCE: method involves antiviral therapy, immune correction with thymus hormones and interferon inductors. Since the first day the relapse symptom method involves prescription of antiox+ (1 capsule per a day) and detox+ (1 capsule, 2 times per a day) for 30 days, profluzak (20 mg, 3 times per a day for 5 days) and then in the dose 20 mg, 1 time per a day for 20 days. Derinate is prescribed topically as installation into urethra in the dose 3-5 ml or with tampon into vagina and with simultaneous prescription of microenemas in the dose 10-40 ml for 10 days. Since 10-14 day in exacerbation period in the proliferative stage of an antiherpetic immune response derinate is prescribed by intramuscular injections in the dose 5 ml, 1 time in a day, 10 injections in total number. Then since 6-th day of exacerbation and intake of profluzak psychotherapy seances are carried out. The first seance of rational psychotherapy involves explanation to a patient in available form mechanism of the disease, the necessity of prolonged treatment and motivation for treatment is enhanced by suggestion. The second psychotherapy seance involves neurolinguistic programming wherein a patient colorful and detailed description of desirable function when he imagines achievement of the desire result, and positive emotional and vegetative symptoms are notes and the conditional-reflect association is formed by tactile contact. Under psychotherapist control a patient imagines "part of person" responsible for achievement of the desire result the patient attention is accented for the desire result and arisen physiological responses are fixed by using tactile contact. Also, new behavior methods are proposed to take for a patient that are directed for achievement of the desire result - avoiding sexual contacts during exacerbation of genital herpes in one of partner and during every month hormonal cycles, avoiding stress situations, and in case of each stress situation significant for patient profluzak has to be intake in a single dose 40 mg, using a condom in sexual contact in the exacerbation period. Patient analyzes the proposed new behavior methods that help avoiding relapses, provide good state of health, promotes to recovery process of genitals recovery and selects at least three the most rationally available for him behavior methods. In the case of the positive response that is controlled by physiological symptoms the result is fixed by tactile contact. The third seance involves the suggestive psychotherapy directed for fixing the attained result. The suggestive therapy seance is carried out once per a week for 6 months. Method provides declining the treatment time, to reduce relapse frequency of genital herpes and to recover the emotional state of patient.

EFFECT: improved treatment method.

2 cl, 3 tbl, 1 ex

 

The invention relates to medicine, namely to infectious diseases and psychiatry is approved for treatment of patients with recurrent genital herpes in the formation of anxiety and depressive disorders.

The basis of mental disorders with recurrent herpes infection, and, in particular, with recurrent genital herpes, are psychogenic in response to acute psychosocial stress on the background of chronic stresses of varying intensity that accompany this infection; netgenie, due to the peculiarities of clinical manifestations of recurrent herpes infection in the form of pronounced pain syndrome and somatogenic due neurotransmi of the herpes simplex viruses type I and II. An important pathogenetic mechanism of the severity of the clinical course of herpes infection is the disintegration of the nervous and immune systems.

The diversity of methods of treatment and prevention of recurrent genital herpes boils down to three main approaches: either immunotherapy or chemotherapy, antiviral drugs, or a combination of these methods. Ongoing treatments are not delivered patient from frequent recurrences of herpes that was exacerbated by a dysfunctional state of mind. Modern understanding of the pathogenesis of recurrent herpetic detail what functions do not allow to stay on a holistic approach to therapy and especially on one drug scheme. The use of a variety of comprehensive treatment programs, including specific antiviral therapy, together with immunomodulating therapy and vaccine therapy proved not to be effective for patients with genital herpes when forming their anxiety and depressive disorders, which required the need to develop comprehensive programs for their rehabilitation, prevent frequent relapses and protracted course, including specific antiviral therapy, immunotherapy and psychopharmacotherapy.

There is a method of treatment of genital herpes with the use of per os valtrex 500 mg 2 times a day for 10 days, neovir 250 mg/m No. 10; after valtrex Azilect in candles 5 doses of 10 days every night vaginally // Kuzovkov T.V., Shcherbakova, NV, Jurowski LI, Evstigneeva, for EXAMPLE, by the Method of treatment of subclinical forms of genital herpes infection in women. "Official Bulletin of the Russian Agency for patents and trademarks, patent No. 2191576, M. CL. 7 a 61 K 31/19, 35/74, a 61 P 31/12. 2002, No. 30 (II h), S.

However, the disadvantage of this method of treatment is short-range, distributed for the period allocation from the mucous membrane of the genital organs and urethral herpes simplex virus type I and II in patients with genital herpes with minimal clinical manifestations or the absence of which their (subclinical), and in the period of exacerbation. It is known that for genital herpes is a chronic recurrent nature, and this method does not save the patient from frequent recurrences of genital herpes. Following the disadvantage of this method of treatment of genital herpes is that it does not take into account neurotropism of herpes simplex virus type I and II and development, as a result of this action on brain cells, the edge of mental disorders, and, in particular, anxiety and depressive disorders.

A known method for the treatment of herpes infection is the use of combinations of drugs of propanone and acyclovir. stage 1: within 7 days groprinosin 500 mg 4 times a day; stage 2: acyclovir 200 mg 5 times a day for 10 days, the cream acyclovir 5 times a day for 10 days // Shabalin, A.R., Hemp A.I., Peshkova E.V. "is a Method of treatment of patients with urogenital herpes virus infection". "Official Bulletin of the Russian Agency for patents and trademarks, patent No. 2189793, M. CL. 7 And 61 In 17/42, And 61 To 31/522, a 61 P 31/12. 2002, No. 27(II h), S.

The disadvantage of this method of treatment of genital herpes is that it does not take into account neurotropism of herpes simplex virus type I and II and development, as a result of this action on brain cells, the edge of mental disorders, and, in addition, this method does not account for is useni in the sexual sphere of the patient recurrent genital herpes and does not prevent the occurrence of relapses.

Also known and the closest way to treat recurrent herpes infection, and, in particular, genital herpes, is a program Isakov V.A., which is as follows: stage 1: chemotherapy in acute period of the disease during 5-10 days in the full - dose acyclovir, valtrex or zovirax; stage 2: immunomodulation in the reparations phase (remission) after remitting the main clinical manifestations to stimulate the completeness of the immune response preparations of interferon - IFN, Poludan, lorivan, and then the rate of thymic hormones and immunomodulators General purpose - prodigiozan, diazepan. Stage duration 30-60 days; stage 3: specific vaccine therapy of any one anti-herpes vaccine is not earlier than 2-3 months after the acute phase of the disease // Isakov V.A. "Therapy of herpetic infection." Saint-Petersburg. The Hippocrates. 1993. - P.40-42.

The disadvantage of this method is the impossibility of conducting vaccine therapy because of frequent recurrences of genital herpes. Only 20-25% of patients with recurrent herpes able to complete the program of complex therapy. The proposed method involves the use of vaccine therapy after the main specific antiviral treatment after 2-3 months of remission of herpes, which is not possible in patients with established have been recovered from the border of mental disorders, namely anxiety and depressive disorders. Mental disorders cause disorders in the immune system of the patient, thereby increasing the secondary manifestations of the immunodeficiency characteristic of recurrent herpes infection, which contributes to the monthly recurrences of herpes.

The present invention is the reduction in the duration of recurrent genital herpes and treatment time, reducing the frequency of recurrences of genital herpes, prevention of recurrent herpes, reducing the severity of recurrence of genital herpes, restoring the emotional state of the patient, reduce anxiety, build confidence in their abilities, appearance and strengthening of positive emotions, creating motivation for recovery, improve the quality of life of the patient with the restoration of the old social and employment status.

This object is achieved by carrying out specific antiviral therapy, immune thymic hormones and inducers of interferon. Additionally, from the first day of relapse appoint antioxidant antioxidant 1 capsule a day and immunocorrector detox 1 capsule 2 times a day for 30 days, antidepressant prilosec 20 mg 3 times day 5 days as preparation of the patient to conduct psychotherapy, then 20 m is 1 time per day for 20 days. Derinat/m 5 ml of 1 times a day through day 10 injections with 10-14 days of aggravation in the proliferative phase antiherpetic immune response and local Derinat from the first day of relapse and the appearance of herpetic lesions and erosions in the form of instillation into the urethra of men 3-5 ml of 10 days or with a tampon in the vagina for women within 10 days, while the micro 10-40 ml of 10 days, starting from the 6th day of exacerbation and admission prilosec. Additionally, conduct psychotherapy sessions. The first session of rational psychotherapy, where therapist tells the patient in an accessible form on the mechanism of the disease and explains the need for long-term treatment, increases motivation for treatment by suggestion in the waking state, the creation of a "resource" health. Second psychotherapeutic session is conducted with the use of neuro-linguistic programming. For this the patient recounts the colorful and detailed description of the desired function, in which is achieving the desired result, while therapist notes the positive emotional and autonomic manifestations and forms a conditioned reflex connection tactile contact. Under the guidance of therapist, the patient imagines "part of personality that is responsible for achieving the desired result, loony therapist enters into communication with the name "part of the personality", focuses the patient's attention on the desired result, establishes emerged physiological reaction using tactile contact and reinforces developed a conditioned reflex. Next, therapist means a connection with certain physical sensations corresponding to a positive or negative response and their appearance in "part of personality" when establishing tactile contact. therapist invites the patient to choose new behaviors aimed at achieving the desired result is to avoid sexual contact during acute genital herpes in one of the partners and during monthly hormonal cycles to avoid stressful situations, be taken during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact in the period of exacerbation, the consent "part of the person" responsible for this function, which monitors therapist physiological manifestations and reinforces conventional tactile contact. The patient analyzes proposed new ways of behaving that will help to prevent relapses, feel good, improve sleep, will contribute to the recovery process of the mucosa of the genital organs and selects at least three of the most realistic ways for him and "part leach the spine takes responsibility for the automatic implementation of these new ways of behaving in the future life of the patient. Upon receipt of a positive response from "part of the personality" finish the second session of psychotherapy, at the third session of psychotherapy spend suggestive psychotherapy aimed at consolidating the achieved results; session suggestive treatment 1 week to 6 months.

Tactile contact is performed by the touch of the physician's hand to the shoulder of the right hand of the patient, the repetition of touch is always held by one and the same movement in the same place with the same force. The novelty of the method lies in the fact that:

- advanced from the first day of relapse appoint antioxidant antioxidant 1 capsule a day and immunocorrector detox 1 capsule 2 times daily for 30 days;

- antidepressant prilosec 20 mg 3 times day 5 days as preparation of the patient to conduct psychotherapy, then 20 mg 1 time a day for 20 days;

- Derinat/m 5 ml of 1 times a day through day 10 injections with 10-14 days of aggravation in the proliferative phase antiherpetic immune response;

- local Derinat from the first day of relapse and the appearance of herpetic lesions and erosions in the form of instillation into the urethra of men 3-5 ml of 10 days or with a tampon in the vagina for women within 10 days, while the micro 10-40 ml of 10 days;

starting from the 6th day of exacerbation and admission prilosec Supplement is Ino conduct psychotherapy sessions, the first session of rational psychotherapy, second psychotherapeutic session using neuro-linguistic programming, at the third session of psychotherapy spend suggestive psychotherapy aimed at consolidating the achieved results;

session suggestive treatment 1 week to 6 months.

When developing a method of combination therapy in patients with recurrent genital herpes at occurrence of anxiety and depressive disorders considered the main premise of combination antiviral, immunomodulating drugs and pharmacotherapy of neurotropism and immunotropnosti of herpes, structural heterogeneity detected secondary immunodeficiency and the presence of its combined forms. As with recurrent genital herpes, in addition to the typical clinical manifestations are formed again and the edge of neuropsychiatric disorders, including anxiety and depressive disorders, we offer a comprehensive therapy that takes into account this factor. While traditional therapy Supplement: antioxidants and immunomodulators by Antiox 1 capsule 1 time a day for 30 days and detox 1 capsule 2 times a day for 30 days. The composition of the antioxidant include grape pomace extract, selenium, zinc oxide, β-carotene, vitamin E, vitamin C and Ginkgo biloba. Part of the detox is the bark of Uncaria tomentosa cat's claw", containing a number of oxindole alkaloids. These drugs help immune system activation, as well as the binding and elimination of free radicals and, therefore, required in treatment, as in the formation of anxiety and depressive disorders in patients with recurrent genital herpes in the blood is often detected elevated levels of medium and macromolecular circulating immune complexes that interfere with the cells of the immune system of the patient. In addition, Ginkgo biloba, part of the antioxidant, improves microcirculation, brain circulation, stabilizes cell membranes, improves blood flow to internal organs, so its inclusion in the comprehensive treatment of patients with recurrent genital herpes at occurrence of anxiety and depressive disorders is justified.

Local Derinat appointed from the first day of relapse and the appearance of herpetic lesions and erosions for healing of erosive surfaces in the form of instillation into the urethra of men 3-5 ml of 10 days, microclysters 10-40 ml of 10 days or with a tampon in the vagina for women within 10 days and also micro 10-40 ml of 10 days. Because Derinat activates processes of cellular and humoral immunity, increases resistance to viral infections, assigned it is even and/m in 5 ml of 1 times a day through day 10 injections to restore the immune system when clinical symptoms subsided with 10-14 days of aggravation in the cast new-vertelney phase antiherpetic the immune response. The ability of the drug to increase the perfusion of internal organs used in patients with failure of genital response, which occurs with frequent recurrences of genital herpes and the formation of anxiety and depressive disorders.

Prescribed antidepressant prilosec from the first day of relapse of genital herpes in the presence of the clinic anxiety-depressive disorder 20 mg 3 times day 5 days as preparation of the patient to conduct psychotherapy, then 20 mg 1 time a day for 20 days to obtain a stable antidepressant and anxiolytic effect. In addition, the patient is taking 40 mg of prilosec in remission in each case important for the patient stressful situation for the prevention of recurrence of genital herpes. The use of this drug improves the patient's mood, reduces fear, anxiety, tension, eliminates restlessness, increases the effectiveness of psychotherapy.

Starting from the 6th day of exacerbation and admission prilosec conduct psychotherapy sessions. The first session of rational psychotherapy, in which the doctor-therapist tells the patient in an accessible form on the mechanism of the disease and the need for further treatment. The patient explained that the herpes virus violates the integrity of the glue is OK skin and mucous membranes, that is accompanied by the appearance of swelling, cracks mucosa and severe pain, this in turn leads to a violation of the emotional state, anxiety, fear, irritability, defensiveness, poor sleep, lack of sexual desire, sexual aversion; herpes virus violates the integrity of the cells of the immune system that leads to immunodeficiency; violates the integrity of brain cells, which exacerbates the already disturbed emotional state; to recover and restore emotional state necessary improvement of damaged brain cells, immune system cells and production of antibodies that will protect You from recurrences of genital herpes and occurrence mental pathology. Increase motivation for treatment by suggestion in the waking state, the creation of a "resource" health. The patient explains that each person has a "resource", while conducting psychotherapy it is activated and helps to cope with the disease. Next, perform a second therapeutic session using neuro-linguistic programming. For this the patient recounts the colorful and detailed description of the desired function, describes his feelings and desired state of health, is the attainment of desire the second result the disappearance of pain, improvement of emotional state, a decrease in feelings of anxiety and fear, irritability, defensiveness, improving sleep, the appearance of high-grade sexual desire. The patient creates a "resource" health status, ie, in a relaxed state mentally represents all the bodies, the integrity and function are disturbed as a result of herpes virus; eliminates pain, mentally restores the integrity of the mucous membranes and skin, the cells of the brain and the immune system renders a holistic picture of the ideal healthy body, a feeling which will adequately created "resource" health, after which the doctor notes the positive emotional and autonomic manifestations and forms a conditioned reflex connection tactile contact. Under the guidance of therapist, the patient imagines "part of the personality", a localized area of the subconscious responsible for the recovery, achieving the desired result. therapist enters into communication with called "part of personality that focuses the patient's attention on the desired result and assigns arising physiological reaction using tactile contact and reinforces developed a conditioned reflex. Next, therapist means a connection with certain physical what sadeniemi, appropriate positive or negative response, and their appearance in "part of personality" when establishing tactile contact, offers the patient to choose new behaviors aimed at achieving the desired result (to avoid sex during acute genital herpes in one of the partners and during monthly hormonal cycles, to avoid stressful situations, be taken during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact in the period of exacerbation), obtains consent "part of personality" reply to this function, which monitors therapist physiological manifestations and establishes conditional tactile contact. The patient analyzes proposed new ways of behaving that will help to prevent relapses, feel good, improve sleep, will contribute to the recovery process of the mucosa of the genital organs and selects at least three of the most realistic ways for him to avoid sex during acute genital herpes in one of the partners and during monthly hormonal cycles to take during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact is in the period of exacerbation). "Part of the personality" takes responsibility for the automatic implementation of these new ways of behaving in the future life of the patient and upon receipt of a positive response from "part of the personality" finish the second session of psychotherapy. At the third session of psychotherapy spend suggestive psychotherapy aimed at consolidating the achieved results, the session suggestive treatment 1 week to 6 months.

Additional inclusion in the treatment of psychotherapy and pharmacotherapy provides obtaining the following result:

1) reduction in the duration of recurrent genital herpes and treatment time,

2) prevention of recurrences of genital herpes

3) reducing the frequency of recurrences of genital herpes

4) reduction of anxiety of the patient,

5) creating motivation for recovery,

6) the emergence and consolidation of the positive emotions of the patient,

7) reduce the severity of recurrent genital herpes

8) strengthening self-confidence,

9) restore the emotional state of the patient,

10) improve the quality of life of the patient with the restoration of the old social and employment status.

The method is as follows. Against the backdrop of ongoing drug therapy, including specific FR the antiviral agents was carried out therapy with acyclovir, by valtrex; immune thymic hormones and inducers of interferon - IFN, Poludan, lariana and polirom, Deuteronomy, prodigiozana; in addition, from the first day of relapse prescribe antioxidants and immunomodulators antioxidant 1 capsule 1 time a day for 30 days and detox 1 capsule 2 times a day for 30 days; Derinat topically in the form of instillation into the urethra of men 3-5 ml of 10 days, while the micro 10-40 ml of 10 days or with a tampon in the vagina for women within 10 days, while the micro 10-40 ml of 10 days and Derinat/m 5 ml of 1 times a day through day 10 injections with 10 to 14 days after acute; antidepressant prilosec from the first day of relapse of genital herpes 20 mg 3 times day 5 days as preparation of the patient to conduct psychotherapy, then 20 mg 1 time a day for 20 days. In addition, the patient is taking 40 mg of the drug in remission in each case important for the patient stressful situation for the prevention of recurrence of genital herpes.

Starting from the 6th day of exacerbation and admission prilosec conduct psychotherapy sessions. The first session of rational psychotherapy, in which the doctor-therapist tells the patient in an accessible form on the mechanism of the disease and explains the need for further treatment. The patient detail RA is Yasnaya, the herpes virus violates the integrity of the cells of the skin and mucous membranes, which is accompanied by the appearance of swelling, cracks mucosa and severe pain, this in turn leads to a violation of the emotional state, anxiety, fear, irritability, defensiveness, poor sleep, lack of sexual desire, sexual aversion; herpes virus violates the integrity of the cells of the immune system that leads to immunodeficiency; violates the integrity of brain cells, which exacerbates the already disturbed emotional state; to recover and restore emotional state necessary improvement of damaged brain cells, immune system cells and production of antibodies, which in the future, will protect You from recurrences of genital herpes and the emergence of mental pathology. Increase motivation for treatment by suggestion in the waking state, the creation of a "resource" health. The patient explained that each person has a "resource", while conducting psychotherapy it is activated and helps to cope with the disease. Next, perform a second therapeutic session using neuro-linguistic programming. For this the patient recounts the colorful and detailed description of the desired function, describes his feelings the desired state of health, is achieving the desired result - the disappearance of pain, improvement of emotional state, a decrease in feelings of anxiety and fear, irritability, defensiveness, improving sleep, appears full of sexual desire. The patient creates a "resource" health status, ie, in a relaxed state mentally represents all the bodies, the integrity and function are disturbed as a result of herpes virus; eliminates pain, mentally restores the integrity of the mucous membranes and skin, the cells of the brain and the immune system renders a holistic picture of the ideal healthy body, a feeling which will adequately created "resource" health, after which the doctor notes the positive emotional and autonomic manifestations and forms a conditioned reflex connection tactile contact. Under the guidance of therapist, the patient imagines "part of the personality", a localized area of the subconscious responsible for the recovery, achieving the desired result. therapist enters into communication with called "part of personality that focuses the patient's attention on the desired result, establishes emerged physiological reaction using tactile contact and reinforces developed a conditioned reflex. Next, psychotherapeutische connection with certain physical sensations, appropriate positive or negative response, and their appearance in "part of personality" when establishing tactile contact, offers the patient to choose new behaviors aimed at achieving the desired result (to avoid sex during acute genital herpes in one of the partners and during monthly hormonal cycles, to avoid stressful situations, be taken during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact in the period of exacerbation), obtains consent "part of personality" reply to this function, which monitors therapist physiological manifestations and establishes conditional tactile contact. The patient analyzes proposed new ways of behaving that will help to prevent relapses, feel good, improve sleep, will contribute to the recovery process of the mucosa of the genital organs and selects at least three of the most realistic ways for him to avoid sex during acute genital herpes in one of the partners and during monthly hormonal cycles to take during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact is in the period of exacerbation). "Part of the personality" takes responsibility for the automatic implementation of these new ways of behaving in the future life of the patient and upon receipt of a positive response from "part of the personality" finish the second session of psychotherapy. At the third session of psychotherapy spend suggestive psychotherapy aimed at consolidating the achieved results, the session suggestive treatment 1 week to 6 months.

Genital herpes in the examined patients was characterized by the periodic appearance of the skin and mucous membrane lesions of varying severity. For the manifested forms of genital herpes were typical bubble rashes, itching, pain, burning, dysuria, regional lymphadenitis. As the development of a painful process bubbles turned into pustules, which was opened with the formation of ulcers. All patients underwent a complete virologic, immunologic, and psychological examination.

Example

Patient O., 40 years old, came to the infectious diseases hospital with complaints of itching, burning, rash in groin, labia, anus, and the fever for a long time. For the first time similar lesions appeared 10 years ago in the face and then in the genital area and anus. Relapses occurred monthly, usually after sex contact is or hormonal cycles. To this specific treatment, anti-herpes therapy, immune disorders and psychotherapy is not received. Was treated by a gynecologist with a diagnosis of Chronic adnexitis. When viewed in the femoral-gluteal folds, labia, the vaginal mucosa is vesiculosa rash with items up to 2 mm Increased to 1.5-2 cm and bolezney inguinal lymph nodes. Blood on herpes in ELISA revealed specific immunoglobulin G titer of 1:800 in smears with elements of an eruption on the mucous membrane of the mouth and genitals of detected antigen HSV type I and II. EEG: the leading melanosarcoma theta and Delta activity in the frontal and temporal areas of the right hemisphere. Reaction to light is well expressed. Hyperventilation without effect. Type EEG: IV - disorganized. The group EEG:11. Significant changes in the EEG of a regulatory nature due to severe dysfunction of the regulatory nonspecific systems of the right hemisphere of the brain. In the study of immune status showed a decrease in T lymphocytes, T helper cells, immunoregulatory index, phagocytic activity of neutrophils, the concentration of immunoglobulins a and G, and the reaction of blast transformation of phytohemagglutinin.

Obsrevations complaints, the patient was weakness, fatigue, sweating, palpitations, dizziness, nervousness, discomfort. Against this background, she watched the camping constant anxiety with frequent mood swings, with concern for their health, heavy sense of foreboding, gloomy thoughts, plunging into them, a lack of confidence in a favorable outcome. Frequent recurrences of herpes formed her suspicion, feelings of inferiority. The patient is extremely sensitive to failures, which aggravate the anxiety and disbelief in the medicine. She has a sexual disorder, sexual aversion, lack of sexual desire, as well as sleep disorders - hypersomnia, night mentis, nightmares during sleep. The patient felt the constant tension, spoke of the hopelessness of their situation; it decreased self-esteem, were ideas of guilt. Noted spiritual emptiness, resentment, lack of joy with the "loss of taste for life", a continuing dissatisfaction with the tendency to create conflict, irritability and bad temper.

Diagnosis: Chronic recurrent genital herpes, moderate, chronic adnexitis. Anxiety-depressive disorder, sexual dysfunction, sleep disorder. Secondary combined structural immunodeficiency with impaired cellular, humoral and monocyte-macrophage immunity.

The patient along with the traditional specific antiviral therapy with acyclovir 200 mg 5 times a day for 4 days and then 200 mg 2 times a day for 10 days is th, the immunotherapy thymic hormone - timagenes at 1 ml/m 10 days inducer of interferon - Radostina 8 mg No. 5 1 every 3 days applied immunotherapy using detox 1 caps. 2 times a day for 30 days and Derinat/m 5 ml through day 10 injections, antioxidant antioxidant 1 caps. daily for 30 days, and pharmacotherapy antidepressant proflush.com 20 mg 3 times a day for 5 days, then 20 mg in the morning of 20 days and 6-day pick - psychotherapy sessions. Derinat also used topically in microclysters with 20 ml of 10 days and vaginally with tampon 10 days.

Starting from the 6th day of exacerbation and admission prilosec conducted psychotherapy sessions. The first session of rational psychotherapy, in which the doctor-therapist tells the patient to her form on the mechanism of the disease and explains the need for further treatment. The patient explained in detail that the herpes virus violates the integrity of the cells of the skin and mucous membranes, which is accompanied by the appearance of swelling, cracks mucosa and severe pain, this in turn leads to a violation of the emotional state, anxiety, fear, irritability, defensiveness, poor sleep, lack of sexual desire, sexual aversion; herpes virus violates the integrity of the cells of the immune system that leads to immunodeficiency; narsaltsbelastning of brain cells, what exacerbates the already disturbed emotional state; to recover and restore emotional state needs to improve the work of the damaged brain cells, immune system cells and production of antibodies that will protect You from recurrences of genital herpes and the emergence of mental pathology. Increased motivation for treatment by suggestion in the waking state, the creation of a "resource" health. The patient explained that each person has a "resource", while conducting psychotherapy it is activated and helps to cope with the disease. Then spent the second psychotherapeutic session using neuro-linguistic programming. In the interview with the doctor, the patient gave a colorful description of his sensations, emotions, the desired state of health; he listed all the symptoms for that undesirable and from which she intends to get rid of. The doctor adjusts, clarifying what the symptom disappears, and what appears, that is, skin rashes disappear, and restored the integrity of the cells of the skin and mucous membranes. Instead of pain, anxiety, disgust, and fear of sexual contact have the feeling of comfort and good mood, healthy sexual feeling and restful sleep. That is, the patient with the doctor in detail specify all parameters is aemula state. The doctor observes symptoms (physiological, vegetative) of positive emotions and generates a conditioned reflex connection tactile contact: the volume and pace of speech, definition, pronunciation, revitalizing facial expressions; the patient flushed face, the voice became louder, more soft, smooth, natural, relaxed, noted the symmetry and uniformity of the gestures, the prevalence of eye movements up-right and down. This meant that the patient actively tuned for recovery. Then the patient was asked about whether she would find the internal forces (reserves)needed to restore his health, normal sexual function, self-esteem, feelings of joy and zest for life, a full life in the family and society. The patient replied: "Yes." The doctor asks the patient: "do it "part of the personality", which could be responsible for solving the problem?". The patient responds "Yes". "Where is it situated?". The patient shows on the solar plexus area and draws on paper the size and shape of this area. Next, the patient says that this part of the Golden sun color radiates warm light and a feeling of joy. To the question: "Will this part of the subconscious to come in contact with her" the patient answers Yes. therapist comes in to the mmunicatio named "part of the personality", focuses the patient on the desired result, establishes emerged physiological reaction using tactile contact and reinforces developed a conditioned reflex. Next, therapist means a connection with certain physical sensations corresponding to a positive or negative answer, and their appearance in "part of personality" when establishing tactile contact, offers the patient to choose new behaviors aimed at achieving the desired result (to avoid sexual contact during acute genital herpes in one of the partners and during monthly hormonal cycles, to avoid stressful situations, be taken during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact in the period of exacerbation), obtains consent "part of personality" reply to this function, which monitors therapist physiological manifestations, and reinforces conventional tactile contact. The patient analyzes proposed new ways of behaving that will help to prevent relapses, feel good, improve sleep, will contribute to the recovery process of the mucosa of the genital organs, and selects at least three of the most achievable to her ways (to avoid flooring the x contacts during acute genital herpes in one of the partners and during monthly hormonal cycles, to take during each significant for the patient stressful situation prilosec 40 mg once, to use a condom during sexual contact during an exacerbation). "Part of the personality" takes responsibility for the automatic implementation of these new ways of behaving in the future life of the patient and upon receipt of a positive response from "part of the personality" finish the second session of psychotherapy. After the psychotherapy patient went cheerful, joyful, with the hope of recovery.

The third session was conducted suggestive psychotherapy aimed at consolidating the achieved result. The session was initiated with a targeted survey of the patient. The doctor first asked about signs of improvement. The patient noted a decrease in lesions, no new, decrease pain, anxiety, improve sleep. The attention of the patient was brought to her subjective feelings of improvement and well-being. At objective inspection also noted a decrease in the number of lesions, the absence of new, reduced redness and swelling of skin and mucous membranes of the genitals, as well as size, pain and density of inguinal lymph nodes, and was communicated to the patient. Any expression of positive emotions, the corresponding subjective wording patients is, the doctor combined with a touch of the hand to the shoulder of the right hand. Repetition touches were always one and the same movement, in the same place, with the same force. Several times the doctor touched the shoulder of the patient in the conversation and watched symptoms of positive emotions and a light hypnotic state. The patient improved mood and sleep, there was inner peace and joy, decreased anxiety and fear. The patient stated that this indicates steadily approaching recovery. In this patient, the first signs of improvement and well-being after the first session of psychotherapy and persistent signs of improvement and well-being after the third session. Session suggestive therapy was performed 1 time per week for 6 months.

Follow-up data

After conducting specific antiviral therapy, immune disorders, antidepressant pharmacotherapy and psychotherapy, the patient's condition has improved. Recovery occurred on the 14th day after acute genital herpes when the previous relapses proceeded for 20 days or more. Relapses in subsequent arose, but much less frequently (1-3 times per year) and proceeded less long-term. In the last year recurrence was not. In addition to the recovery of visual functions in PA is yendi normalized and psychic condition disappeared anxiety and fear, lined mood, increased self-esteem, improve sleep, disappeared nightmares, restored full relations with her husband, improved relations with colleagues. The feeling of inferiority, irritability, guilt, suspicion, defensiveness. The patient grew calmer, more confident, more optimistic.

Using this method of treatment, which includes specific antiviral therapy, immunotherapy, antidepressant pharmacotherapy, rational psychotherapy, psychotherapy method of neuro-linguistic programming and suggestive psychotherapy, was treated 42 patients with recurrent genital herpes with anxiety and depressive disorders (Tables 1-3). Analysis of the obtained post-treatment results showed the improvement of the mind, increase stress resistance in patients, reducing anxiety, stimulation of activity of the patient, decreasing term elegicheskogo syndrome, acceleration of reparative processes of the mucous membrane and skin, reduction of terms of vesicularia and epithelization, the stability of the positive dynamics of reparative process, reducing the frequency and duration of recurrences of herpes. Symptoms of recovery can be clearly objectivesyou. Everything points to the efficacy of psychotherapeutic IU the ode in the complex with specific antiviral therapy, the immunotherapy and pharmacotherapy with antidepressants and anti-oxidants in the treatment of genital herpes in the formation of anxiety and depressive disorders.

Table 1

The outcomes of relapse in patients with genital herpes with anxiety-depressive disorders, depending on the treatment method
ExodusIMM/correction +p/viral n-25IMM/correct+p/viral+CFT n-42
And full clinical recovery18-72%36-85,7%
In practical recovery5-20%6-14,3%
With incomplete clinical recovery2-8%0
The average duration of a relapse21/DN14/DN

Table 2

The frequency of relapses in patients with genital herpes with anxiety-depressive disorders, depending on the treatment method
The recurrence rateJust n-67IMM/correction +p/viral n-25IMM/correct+p/viral+CFT n-42
1-2 times/year22-33%5-20%17-40,5%
3 - times/year 37-55%16-64%21-50%
5-6 times/year8-12%4-16%4-9,5%
Only67-100%25-100%42-100%

Table 3

The duration of relapse in patients with genital herpes with anxiety-depressive disorders, depending on the treatment method
The duration of the relapseJust n-67IMM/correction +p/viral n-25IMM/correct+p/viral+CFT n-42
5-7 days12-18%2-8%10-24%
8-12 days30-45%9-36%21-50%
2 weeks23-34%12-48%11-26%
3 weeks2-3%2-8%0
Only67-100%25-100%42-100%

1. Method of treatment of recurrent genital herpes in the formation of anxiety and depressive disorders, including specific antiviral therapy, immunotherapy thymic hormones and inducers of interferon, characterized in that it further from the first day of Vozniknovenie what I relapse appoint antioxidant 1 capsule a day and detox 1 capsule 2 times a day for 30 days, prilosec 20 mg 3 times a day for 5 days, then 20 mg 1 time a day for 20 days, locally appointed Derinat in the form of installations in the urethra 3-5 ml or with a tampon in the vagina with simultaneous appointment microenemas in 10-40 ml for 10 days, 10-14 days after deterioration in the proliferative phase antiherpetic immune response Derinat administered intramuscularly in a dose of 5 ml of 1 times a day, 10 injections; however, starting from the 6th day of exacerbation and admission prilosec additionally conduct psychotherapy sessions: the first session rational psychotherapy tell the patient in an accessible form, the mechanism of the disease, explain the need for long-term treatment and suggestion increase motivation for treatment; at the second session of psychotherapy use neuro-linguistic programming, for that the patient sets out the colorful and detailed description of the desired function, in which is achieving the desired result, while celebrating positive emotional and autonomic manifestations and form a conditioned reflex connection tactile contact; under the direction of the psychotherapist, the patient imagines the part of the person"responsible for the achievement of the desired outcome and focus the patient's attention on the desired result and fix arisen physiological reaction with omodulating contact reinforcing developed a conditioned reflex, offer the patient to choose new behaviors aimed at achieving the desired result is to avoid sexual contact during acute genital herpes in one of the partners and during monthly hormonal cycles, to avoid stressful situations and significant for each of the patient stress to take prilosec 40 mg once, to use a condom during sexual contact in the period of exacerbation; the patient analyzes proposed new behaviors that help to prevent relapses, feel good, improve sleep, promote the process of recovery of the mucosa of the genital organs and selects at least three of the most rationally achievable ways for him behavior upon receipt of a positive response, which track on the physiological manifestations, and reinforce the tactile contact; at the third session conducted suggestive psychotherapy aimed at consolidating the achieved results; session suggestive therapy is carried out 1 time a week for 6 months.

2. The method according to claim 1, characterized in that the tactile contact is performed by the touch of the hand to the shoulder of the right hand of the patient, you touch and hold one and the same movement in the same place with the same si is Oh.



 

Same patents:

FIELD: veterinary virology and biotechnology.

SUBSTANCE: invention proposes the strain that possesses high antigenic and immunogenic activity. The strain is deposited in the Collection of microorganism strain FGU VGNKI at the registration name "VNIIZZH-DEP". The coronavirus strain is reproduced in transplanted cell cultures of calf kidney (MDVK, Taurus), calve coronary vessel cells and in heterologous culture of simian cells (Vero). After 3-4 days of incubation at 37°C virus is accumulated in the amount up to 108 particels/cm3 by data of electronic microscopy. The strain shows ability for reproducing in the same accumulation degree in cell culture MDVK at 34°C. The strain possesses high biological, antigenic and immunogenic activity and retains native immunobiological properties after inactivation and can be used in preparing highly sensitive and specific diagnostic, highly immunogenic, harmless and areactogenic vaccine and curative preparations.

EFFECT: valuable properties of strain, improved preparing method.

6 tbl, 4 ex

FIELD: veterinary virology, biotechnology.

SUBSTANCE: invention relates to the strain "K-58" that is deposited in the Collection FGU VGNKI at the registration number '"K-58" № 122 - DEP". The strain is reproduced in 9-11-old SPF-chicken embryos with titer value of biological activity 5.5-7.0 lg EID50/0.2 cm3. The strain is stable and harmless. Its attenuation stability is found in carrying out 5 passages in sensitive chickens. The strain shows high biological, immunogenic and antigenic activities in native state and after inactivation and useful for preparing highly specific and sensitive diagnostics and harmless live and inactivated vaccine preparations.

EFFECT: valuable veterinary properties of strain.

7 tbl, 8 ex

FIELD: veterinary virology, veterinary science, biotechnology.

SUBSTANCE: vaccine comprises antigenic material from the strain "VNIIZZH-DEP" of the cattle infectious rhinotracheitis virus reproduced in transplanted cells culture taken among transplanted cells BHK-21, MDBK and ZKG with the biological activity value at least 6.0 lg TCD50/cm3 and inactivated with aminoethylethyleneimine and also aluminum hydroxide as an adjuvant and, additionally, saponin taken in the effective ratios. The strain is deposited in the collection VGNKI at the registration code "VNIIZZH-DEP". Virus of the strain "VNIIZZH-DEP" is reproduced in transplanted cultures of cells BHK-21, MDBK and ZKG inducing cytopathic effect and virus is accumulated with the titer value 6.5-8.0 lg TCD50/cm3 for 48-96 h. Aminoethylethyleneimine is used in the concentration 0.1-0.2%, aluminum hydroxide is used as 3-4% gel in the amount 19.6-49.6 wt.-% and saponin is used as 10% aqueous solution in the amount 0.4 wt.-%. Vaccine shows high antigenic and immunogenic activity and harmless.

EFFECT: valuable properties of vaccine.

18 cl, 8 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with treating vestibular and auditory disorders, trigeminal nerve's neuralgia and peripheral paresis of facial nerve of herpetic etiology. The method deals with introduction of an antiherpetic preparation followed by immunomodelling therapy with the use of polyoxidonium. Moreover, after treating with antiherpetic preparation before introducing polyoxidonium it is necessary to conduct additional successive therapy: with preparations of trophic action as milgamma or neuromultivit at simultaneous introduction of antioxidant, then comes intratissue injection of cerebrolysine being behind the top of mastoid process.

EFFECT: the innovation enables to decrease the quantity of relapses due to stopping the development of herpes simplex virus, restore conductivity along nervous fiber and improve endoneural circulation.

3 cl, 3 ex

Medicinal agent // 2268037

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to using 4-chloro-2-methylphenoxyacetic acid of the formula (I)

and its pharmacologically acceptable sodium, potassium and lithium salts (mixture of these salts, or mixture of salts and 4-chloro-2-methylphenoxyacetic acid) as a medicinal agent possessing immunomodulating, anti-inflammatory and antitumor properties, and antiviral activity also. 4-Chloro-2-methylphenoxyacetic acid and its mixtures with pharmacologically acceptable alkaline metal salts possess high effectiveness and enhanced bioavailability.

EFFECT: valuable medicinal properties of medicinal agent.

9 cl, 13 ex

FIELD: chemistry of peptides, medicine.

SUBSTANCE: invention relates to preparing new peptides possessing immunomodulating, anti-proliferative, anti-tumor and antiviral activity. Invention proposes new peptides comprising up to 30 amino acid residues of the general structural formula: X1-Trp-Gly-Gln-X2 wherein X1 is taken among the following group: -His-Gly-Val-Ser-Gly-, -His-Gly-Gly-Gly-, -His-Val-Gly-Gly-, -His-Gly-Gly-Gly-Gly-, and -Gln-Gly-Gly-Gly-Gly, or absent; X2 is taken among the following group: -His-Gly-Thr-His-Gly, -Gly-Gly-Thr-His-Gly, -Pro-His-Val-Gly-Gly, -Pro-His-Gly-Gly-Gly, -Pro-His-Gly-Gly-Gly-Trp-Gly, -Gly-Gly-Gly-Thr-His-Ser, or absent.

EFFECT: valuable medicinal properties of peptides.

8 cl, 5 tbl, 5 dwg, 6 ex

FIELD: organic chemistry, medicine, virology.

SUBSTANCE: invention relates to new derivatives of piperidine of the general formula (II): or their pharmaceutically acceptable salts wherein Xa means -C(R13)2-, -C(R13)(R19)-, -C(O)-, and others; Ra means R6a-phenyl or phenyl substituted with methylsulfonyl; R1 means hydrogen atom or (C1-C6)-alkyl; R2 means R7-, R8-, R9-phenyl wherein R7-, R8 and R9 mean substituted 6-membered heteroaryl and others; R3 means R10-phenyl, pyridyl and others; R4 means hydrogen atom, (C1-C6)-alkyl, fluoro-(C1-C6)-alkyl; R6a means from 1 to 3 substitutes taken among the group involving hydrogen, halogen atom, -CF3 and CF3O-; R7 and R8 mean (C1-C6)-alkyl and others; R9 means R7, hydrogen atom, phenyl and others; R10 means (C1-C6)-alkyl, -NH2 or R12-phenyl wherein R12 means hydrogen atom, (C1-C6)-alkyl and others; R13, R14, R15 and R16 mean hydrogen atom or (C1-C6)-alkyl; R17 and R18 in common with carbon atom to which they are bound form spirane ring comprising from 3 to 6 carbon atoms; R19 means R6-phenyl wherein R6 means R6a or methylsulfonyl; R20, R21 and R22 mean hydrogen atom or (C1-C6)-alkyl; R23 means (C1-C6)-alkyl under condition that if Ra means phenyl substituted with methylsulfonyl then Xa can mean the group only. Compounds of the formula (II) possess properties of CCR5-antagonist and can be used in medicine in treatment of HIV-infection.

EFFECT: improved method for treatment, valuable medicinal properties of compounds and composition.

15 cl, 1 dwg, 12 tbl, 15 ex

FIELD: virology, veterinary science.

SUBSTANCE: invention proposes a new strain of the avian reovirus ESASS № 99011475 belonging to a new antigen class of avian reoviruses. Also, invention proposes a method for preparing such reoviruses, a vaccine comprising such reovirus, a method for its preparing and a method for control against pathological states in poultries by using such vaccine. Proposed group of inventions provides enhancing the effectiveness of vaccination of poultries against reoviruses. Invention can be used in veterinary.

EFFECT: improved preparing method, valuable properties of strain and vaccine.

9 cl, 6 dwg, 3 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: one should perform the following stages: a) removal of contaminants out of plant; b) plant's reducing; c) treatment of reduced plant with laser radiation; d) suspending the mixture obtained at stage c) in water; e) maceration of suspension obtained at stage d) and f) separation of liquid developed. Composition should be obtained due to this technique. It should be applied at treating hepatitis C as an aqueous extract. It should be applied as aqueous extract as immunostimulant. Pharmaceutical preparation includes aqueous extract as an active constituent.

EFFECT: increased biological activity of the product.

43 cl, 16 ex, 1 tbl

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new urea-substituted imidazoquinolines of the formula (1):

wherein R, R1, R2 and n have values given in the description, and to pharmaceutical preparations based on these compounds. Proposed compounds possess effect of immunomodulators initiating biosynthesis of different cytokines. Also, invention relates to methods for treatment of different states, among them viral diseases and neoplastic pathologies.

EFFECT: improved method for induction, valuable properties of compounds.

47 cl, 11 tbl, 142 ex

FIELD: medicine, gynecology.

SUBSTANCE: it is necessary to carry out combined medicinal and physiotherapeutic impact. Mixture of pharmacological preparations consisting of 80 mg gentamycine, 16 U lidase and 4 ml 2%-lidocaine solution should be injected submucosally into lateral vaginal arches followed by dynamic electroneurostimulation in area of uterine adnexa projection for 30 min. Therapy course lasts for 7 d. The innovation enables to shorten therapy terms and prevent the development of complications due to applying physiotherapeutic impact in acute period of purulent-inflammatory process.

EFFECT: higher efficiency of therapy.

FIELD: medicine, andrology.

SUBSTANCE: boiling velvet antlers water should be applied in the form of aerosol onto "panties" area of patient's body surface in combination with dry heat thrice every other day, about 8-10 procedures/course. The innovation enables to minimize the load upon cardio-vascular system and enhance surface circulation.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine, endocrinology, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition comprising drospirenone as the first active agent in the amount corresponding to daily dose from 2 to 4 mg in administration of the composition, and ethynylestradiol as the second active agent in the amount corresponding to daily dose from 0.01 to 0.05 mg in combination with one or some pharmaceutically acceptable vehicles or additives. Drospirenone as a component of the pharmaceutical composition is in the finely divided form. The preparation comprises some separately packages and individually taken medicinal units placed in the unit package and designated for oral administration for at least 21 days at a time and indicated daily medicinal units comprise the combination of drospirenone and ethynylestradiol. The preparation can comprise 7 and less daily doses no containing any active agent or containing ethynylestradiol only. The combination of ethynylestradiol and drospirenone provides the safety contraceptive activity due to using the maximal dose of drospirenone being without adverse effects, in particular, excessive diuresis.

EFFECT: improved and valuable properties of combination.

34 cl, 5 dwg, 5 ex

FIELD: medicine, endocrinology, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition comprising drospirenone as the first active agent in the amount corresponding to daily dose from 2 to 4 mg in administration of the composition, and ethynylestradiol as the second active agent in the amount corresponding to daily dose from 0.01 to 0.05 mg in combination with one or some pharmaceutically acceptable vehicles or additives. Drospirenone as a component of the pharmaceutical composition is in the finely divided form. The preparation comprises some separately packages and individually taken medicinal units placed in the unit package and designated for oral administration for at least 21 days at a time and indicated daily medicinal units comprise the combination of drospirenone and ethynylestradiol. The preparation can comprise 7 and less daily doses no containing any active agent or containing ethynylestradiol only. The combination of ethynylestradiol and drospirenone provides the safety contraceptive activity due to using the maximal dose of drospirenone being without adverse effects, in particular, excessive diuresis.

EFFECT: improved and valuable properties of combination.

34 cl, 5 dwg, 5 ex

FIELD: medicine, obstetrics.

SUBSTANCE: one should conduct antibacterial therapy 3 mo before planned pregnancy consisting of preparations of tetracyclinic group or macrolides in combination with nystatin and metronidasol to continue it since the first day of menstrual cycle and, also, it is necessary to perform correction of vaginal biocenosis, and about 3-4 wk after therapy carried out for 2 next mo before planned pregnancy starting, also, since the first day of menstrual cycle - metabolic therapy; At the onset of pregnancy one should conduct courses for preventing placental deficiency dealing with introduction of preparations that improve uterine-placental circulation, and preparations that improve rheological properties of blood and vitamin-metabolic therapy or the same preparations, and additionally - introduction of macrolides ad viferon rectally in case of activation of chlamydial infection. The present innovation enables to sanitize uterine cavity, improve uterine-placental circulation, restoration of placental tissue structure that, in its turn favors the birth of healthy generation.

EFFECT: higher efficiency of prophylaxis.

1 cl, 9 tbl

FIELD: veterinary pharmacology.

SUBSTANCE: The suggested method deals with interaction of valerianic acid anhydride with steroid alcohol - 17α-acetoxy-3β-hydroxy-6-methylpregna-4.6-dien-20-on at molar ratio being 1.1-1.5:1 to steroid, which should be implemented in pyridine medium in volume-weight ratio of 1.5-2.0:1 pyridine to steroid at 22-25°C, excess of anhydride should be hydrolyzed with water at the quantity of 15-20% against the volume of reaction mass, as for developed valerianic acid, it should be dissolved in 1-1.5%-ammonia aqueous solution and a target product should be filtered, washed with water up to neutral reaction to be washed with methanol. The innovation provides obtaining new target product of higher purification degree.

EFFECT: higher efficiency.

7 ex, 7 tbl

FIELD: medicine, obstetrics, gynecology.

SUBSTANCE: one should intravenously inject Reamberin 1.5% up to 400 ml solution daily, percutaneously affect with magneto-infrared laser, wave length being 0.89 mcm, impulse power of infrared radiation corresponds to 4 W. One should affect uterine and adnexal area alternatively, at exposure being about 2-3 min for every region, radiation frequency being 5 Hz and 50 Hz altered every other day. Since the second day of therapy one should additionally supply laser light flow directly towards uterine area through vaginal arch for 1 min at frequency of 1000 Hz. Total course of therapy corresponds to about 5-7 d. The innovation enables to increase immunological body strength, decrease relapse frequency and decrease side effects of curative preparations applied.

EFFECT: higher efficiency of therapy.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves introducing 0.06% sodium hypochlorite solution from intravaginally arranged cathode during 10-15 min every session in 5-7 days long course.

EFFECT: reduced risk of abdominal pregnancy relapses; retained reproductive function.

1 tbl

FIELD: medicine, obstetrics.

SUBSTANCE: the present innovation deals with introducing the complex of medicinal preparations directed for treating different complications during pregnancy. Moreover, along with applying the above-mentioned complex it is necessary to introduce actovegin as uterotonic remedy per 2 tablets thrice daily. The innovation enables to normalize myometrium state and that of uterine-placental circulation at efficiency being 93%.

EFFECT: higher efficiency.

2 ex

FIELD: medicine, gynecology, surgery.

SUBSTANCE: one should introduce 3.5%-chitosan ascorbate gel into fistulous channel that contains metronidasol at the dosage of 2 mg/ml, at the volume up to 20 ml once/2 d till complete fistula's closing. The present innovation enables to activate reparative processes and fistulous epithelization that favors for closing fistulous channel in earlier terms.

EFFECT: higher efficiency of therapy conducted.

2 ex

FIELD: medicine, in particular, sanitation physical culture.

SUBSTANCE: method involves teaching patient to breathing-muscular procedure including sequential straining of hand, forearm, and shoulder muscles in synchronism with inhalation and relaxation thereof in reverse sequence in synchronism with expiration, and in the same manner - of lower limb and body muscles; causing patient to familiarize himself with feeling of movable muscle tension or relaxation - breathing muscular wave; during exercising, teaching to produce breathing muscular wave of different directivity, rhythm and expressiveness; providing correction of organism's functional state by placing patient's hands onto investing tissues in projection of organ; pressing for fixing organ and providing rhythmical motions of knees to the right, to the left while drawing pelvis and abdomen into motion; performing bending and unbending body motions in sitting, standing and lying positions, with deep breathing with different kinds of breathing-muscular wave being used during performing of bending and unbending motions.

EFFECT: increased efficiency owing to acting upon different levels of metameric-receptor field of internal organs.

1 ex

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